US3923207A - Microliter syringe for dispensing small, accurately measured quantities of fluid specimens - Google Patents

Microliter syringe for dispensing small, accurately measured quantities of fluid specimens Download PDF

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Publication number
US3923207A
US3923207A US454838A US45483874A US3923207A US 3923207 A US3923207 A US 3923207A US 454838 A US454838 A US 454838A US 45483874 A US45483874 A US 45483874A US 3923207 A US3923207 A US 3923207A
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Prior art keywords
plunger
guide means
guide
syringe
bore
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US454838A
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Tuneyoshi Kyogoku
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Jintan Terumo Co Ltd
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Jintan Terumo Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B01L3/022—Capillary pipettes, i.e. having very small bore
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • A61M5/31531—Microsyringes, e.g. having piston bore diameter close or equal to needle shaft diameter

Definitions

  • a mieroliter syringe has a hollow guide mounted to one end of a syringe body into which a plunger is inserted. The plunger can be smoothly inserted into. and removed from, the syringe body through the guide without causing any eventual bending or buckling.
  • FIG. 3A FIG. 38 FIG. 3C
  • MICROLITER SYRINGE FOR DISPENSING SMALL, ACCURATELY MEASURED QUANTITIES OF FLUID SPECIMENS This invention relates to a microliter syringe for dispensing small, accurately measured quantities of fluid specimens, and particularly to a microsyringe in which a plunger can be smoothly inserted into and removed from the syringe body.
  • a microliter syringe as used in a gas chromatography analysis etc. is adapted to dispense small quantities of medicament and a stainless wire of, for example, 0.5 mm in diameter is used as a plunger for the syringe.
  • a stainless wire of, for example, 0.5 mm in diameter is used as a plunger for the syringe.
  • the syringe is required to have such a construction as is easily cleaned for repeated use, and any complicated construction is therefore undesirable, since a delicate operation is carried out.
  • a microsyringe comprising a syringe body having an inner bore for permitting liquid to be inserted along its axial direction; a cannula mounted to one end of the syringe body and communicating with the inner bore of the syringe body; a flexible hollow guide mounted to the other end of the syringe body and communicating with the inner bore of the syringe body; and a plunger adapted to be slidably reciprocated within the bore of the hollow guide and the bore of the syringe body.
  • FIG. 1 is a side view showing a microliter syringe according to this invention
  • FIG. 2 is a cross-sectional view, partly broken away, showing an upper section of the microliter syringe of FIG. 1;
  • FIGS. 3A to 3C are cross-sectional views each showing a modification of a hollow guide for the microliter syringe according to this invention.
  • FIG. 4 is a cross-sectional view, partly broken away, showing the manner in which a plunger is inserted slantwise into a syringe body through a guide;
  • FIG. 5 is a cross-sectional view, partly broken away, showing the manner in which a plunger is inserted slantwise into a syringe body, wherein a flexible hollow guide is not employed.
  • FIG. 1 there is shown a syringe body 1 made of a cylindrical, thick-walled transparent glass.
  • a syringe body 1 made of a cylindrical, thick-walled transparent glass.
  • An axially penetrating inner bore 2 into which liquid can be introduced.
  • a cannula 3 is mounted to one end of the syringe body 1 so as to communicate with the inner bore 2.
  • a scale 4 for indicating an amount of liquid is marked on the outer surface of the syringe body 1.
  • a mounting hole 6 is provided coaxially with the inner bore and a hollow guide 7 can be detachably fitted into the mounting hole.
  • the hollow guide 7 is made of either plastic resin such as fluorine resin etc. or a flexible material such as glass fiber etc. and is substantialy cylindrical in shape.
  • the guide is larger in outer diameter at its base end portion than at its free end portion. As a result, the guide is more flexible at its free end portion than at its base end portion.
  • a rib 6 is provided short of the base end of the guide.
  • the rib is snap-fitted into a groove provided in the inner surface of the mounting hole 6.
  • the rib may be provided on the inner surface of the mounting hole and, in this case, the associated groove is provided in the outer surface of the guide.
  • the guide 7 can be easily snap-fitted into the flange 5 by merely pushing the former into the hole of the latter and it can be easily removed from the flange by merely pulling the guide relative to the flange.
  • the guide 7 may be detachably screw-threaded into the flange. Any detachable arrangement may be adopted in this case.
  • the plunger 8 is made of a stainless steel having an outer diameter of, for example, 0.5 mm and is intimately insertible into the bore of the guide 7 and the inner bore of the syringe body.
  • a knob 10 is mounted at the top of the plunger 8. It is preferred that a length between the knob 10 and the top end of the guide 7, which is defined when the plunger 8 is pushed down to its limit i.e. the forward end of the plunger 8 is abutted against the penetrating end of the cannula 3 to indicate a zero position on the scale, be not more than several millimeters or preferably of the order of 1 mm.
  • a length 1 between the upper end surface of the flange 5 and the lower end surface of the knob is preferably at least sufficient for a human finger to be inserted therebetween.
  • the hollow guide 7 may take a variety of forms as shown in FIGS. 3A, 3B and 3C.
  • the guide shown in FIG. 3A takes a cylindrical form.
  • the guide shown in FIG. 3B takes a frusto-conical form and, therefore, pliability is increased toward the top of the frusto-conical guide.
  • the guide shown in FIG. 3C is similar in shape to that shown in FIGS. 1-2 and the mouth of the guide is funnel-shaped, permitting an easy insertion of the plunger as well as preventing buckling of the plunger.
  • the guide is pliably bent at a flexible section 9 and the plunger 8 can be smoothly pushed into the bore of the syringe body without any appreciable resistance. Furthermore, even if the plunger is pliably bent, the guide is correspondingly bent so that the plunger does not buckle. And any tendency for the plunger to be eventually bent can also be avoided due to the pliable or flexible nature of the hollow guide.
  • the plunger When the plunger is manually pushed down to the zero position on the scale and abutted against the penetrating end of the cannula, a manual depressing force is concentrated on the exposed portion of the plunger. Since, however, the length 1 so defined between the upper end surface of the plunger and the lower end surface of the knob is not more than several millimeters or preferably of the order of about 1 mm, the plunger does not buckle even if any slant force is applied to the plunger. If any guide is not mounted to the syringe body through the flange, a space necessary for a manual operation is required between the flange 5 and the knob and, consequently, the exposed surface of the plunger as defined between the flange and the knob is made longer.
  • a length between the knob 10 and the guide 7 can be reduced to about 1 mm and a resistance to buckling is further increased. Furthermore, any eventual bending or plastic deformation as well as buckling of the plunger can be avoided due to the pliable section 9 of the guide.
  • the plunger 8 and guide 7 can be, after removal from the syringe body, cleaned separately.
  • the guide is easy to handle during cleaning, since it is detachably mounted to the syringe body through the flange.
  • the flexible or pliable guide is mounted to the syringe body.
  • This arrangement can prevent any eventual bending or buckling of the plunger as occurring when the plunger is inserted into the syringe body and even when the inseition is nearly completed. Furthermore, the arrangement provides a longer space between the flange and the knob due to the presence. of the guide so that the plunger can be easily manipulated.
  • the hollow guide is simple in construction and is removably mounted, for example, through the flange, to the syringe body, a cleaning operation can be easily carried out. Consequently, practical advantages are obtained according to this invention.
  • the guide can be fixedly secured to the syringe body if circumstances permit.
  • a microliter syringe for dispensing small, arcuately measured quantities of fluid specimens comprising:
  • a syringe body having a small bore therethrough
  • a cannula mounted on one end of said body and communicating with the said bore;
  • a guide means mounted on the other end of said body with said plunger extending slidably therethrough, said guide means being readily bendable in response to lateral forces on said plunger outwardly of said guide whereby said guide means prevents kinking of said plunger upon operation of said syringe with the portion of said plunger in said bore being angularly related to the portion thereof extending outwardly of said body.
  • a microliter syringe according to claim 1 in which said guide means is more readily bendable at its free end portion than at its base portion.
  • a microliter syringe according to claim 2 in which said guide means is thinner at its free end portion than at its base portion.
  • a microliter syringe according to claim 1 in which said guide means is substantially cylindrical in shape.
  • a microliter syringe according to claim 1 in which a knob is mounted on the free end of the plunger; a flange is mounted on the said other end of the syringe body; and wherein the distance between the flange and the knob is sufficient for a human finger to be inserted therebetween; and the distance between the knob and the upper end of the guide means when the plunger is pushed down to its limit is about 1 mm.
  • a microliter syringe according to claim 1 in which said guide means is provided with a funnel-shaped mouth at its outer end for guiding said plunger therethrough.

Abstract

A microliter syringe has a hollow guide mounted to one end of a syringe body into which a plunger is inserted. The plunger can be smoothly inserted into, and removed from, the syringe body through the guide without causing any eventual bending or buckling.

Description

United States Patent Kyogoku Dec. 2, 1975 MICROLITER SYRINGE FOR DISPENSING SMALL, ACCURATELY MEASURED QUANTITIES OF FLUID SPECIMENS Inventor: Tuneyoshi Kyogoku, Fujinomiya Japan Assignee: Jintan Terumo Co., Ltd., Tokyo,
Japan Filed: Mar. 26, 1974 Appl. No.: 454,838
Foreign Application Priority Data Mar. 29. 1973 Japan 48-38040 US. Cl. 222/386; 128/218 P Int. C1. GOlF 11/00 Field of Search..." 222/386; 128/218 R. 218 P. 128/218 C, 218 PA, 218 N, 218 M, 218 A, 218 G, 218 S, 221. 218 NV Primary E.\aminerAllen N. Knowles Attorney. Agent, or Firm-Bacon & Thomas [57] ABSTRACT A mieroliter syringe has a hollow guide mounted to one end of a syringe body into which a plunger is inserted. The plunger can be smoothly inserted into. and removed from, the syringe body through the guide without causing any eventual bending or buckling.
7 Claims, 7 Drawing Figures L 'fi 5 US. Patent Dec. 2, 1975 FIG. 2
FIG. 3A FIG. 38 FIG. 3C
MICROLITER SYRINGE FOR DISPENSING SMALL, ACCURATELY MEASURED QUANTITIES OF FLUID SPECIMENS This invention relates to a microliter syringe for dispensing small, accurately measured quantities of fluid specimens, and particularly to a microsyringe in which a plunger can be smoothly inserted into and removed from the syringe body.
A microliter syringe as used in a gas chromatography analysis etc. is adapted to dispense small quantities of medicament and a stainless wire of, for example, 0.5 mm in diameter is used as a plunger for the syringe. When this plunger is inserted into a syringe, it is liable to buckle. To prevent such buckling, a variety of proposals has been made to this date. However, microliter syringes of the prior art are rather elaborate in design to avoid such buckling.
Furthermore, the syringe is required to have such a construction as is easily cleaned for repeated use, and any complicated construction is therefore undesirable, since a delicate operation is carried out.
It is accordingly the object of this invention to provide an easily cleanable microliter syringe of simple construction, in which a plunger is smoothly inserted into and removed from a syringe body through a hollow guide without causing any buckling.
According to this invention there is provided a microsyringe comprising a syringe body having an inner bore for permitting liquid to be inserted along its axial direction; a cannula mounted to one end of the syringe body and communicating with the inner bore of the syringe body; a flexible hollow guide mounted to the other end of the syringe body and communicating with the inner bore of the syringe body; and a plunger adapted to be slidably reciprocated within the bore of the hollow guide and the bore of the syringe body.
This invention can be more fully understood from the following detailed description when taken in conjunction with the accompanying drawing, in which:
FIG. 1 is a side view showing a microliter syringe according to this invention;
FIG. 2 is a cross-sectional view, partly broken away, showing an upper section of the microliter syringe of FIG. 1;
FIGS. 3A to 3C are cross-sectional views each showing a modification of a hollow guide for the microliter syringe according to this invention;
FIG. 4 is a cross-sectional view, partly broken away, showing the manner in which a plunger is inserted slantwise into a syringe body through a guide; and
FIG. 5 is a cross-sectional view, partly broken away, showing the manner in which a plunger is inserted slantwise into a syringe body, wherein a flexible hollow guide is not employed.
This invention will be further explained by reference to the accompanying drawing.
In FIG. 1 there is shown a syringe body 1 made of a cylindrical, thick-walled transparent glass. In the central portion of the syringe body is provided an axially penetrating inner bore 2 into which liquid can be introduced. A cannula 3 is mounted to one end of the syringe body 1 so as to communicate with the inner bore 2. A scale 4 for indicating an amount of liquid is marked on the outer surface of the syringe body 1. To the other end of the syringe body a flange 5 is mounted to permit a plunger 8 to be easily reciprocated. In the flange 5 a mounting hole 6 is provided coaxially with the inner bore and a hollow guide 7 can be detachably fitted into the mounting hole. The hollow guide 7 is made of either plastic resin such as fluorine resin etc. or a flexible material such as glass fiber etc. and is substantialy cylindrical in shape. The guide is larger in outer diameter at its base end portion than at its free end portion. As a result, the guide is more flexible at its free end portion than at its base end portion. As shown in FIG. 2, a rib 6 is provided short of the base end of the guide. The rib is snap-fitted into a groove provided in the inner surface of the mounting hole 6. The rib may be provided on the inner surface of the mounting hole and, in this case, the associated groove is provided in the outer surface of the guide. The guide 7 can be easily snap-fitted into the flange 5 by merely pushing the former into the hole of the latter and it can be easily removed from the flange by merely pulling the guide relative to the flange. The guide 7 may be detachably screw-threaded into the flange. Any detachable arrangement may be adopted in this case.
The plunger 8 is made of a stainless steel having an outer diameter of, for example, 0.5 mm and is intimately insertible into the bore of the guide 7 and the inner bore of the syringe body. A knob 10 is mounted at the top of the plunger 8. It is preferred that a length between the knob 10 and the top end of the guide 7, which is defined when the plunger 8 is pushed down to its limit i.e. the forward end of the plunger 8 is abutted against the penetrating end of the cannula 3 to indicate a zero position on the scale, be not more than several millimeters or preferably of the order of 1 mm. A length 1 between the upper end surface of the flange 5 and the lower end surface of the knob is preferably at least sufficient for a human finger to be inserted therebetween. The hollow guide 7 may take a variety of forms as shown in FIGS. 3A, 3B and 3C. The guide shown in FIG. 3A takes a cylindrical form. The guide shown in FIG. 3B takes a frusto-conical form and, therefore, pliability is increased toward the top of the frusto-conical guide. The guide shown in FIG. 3C is similar in shape to that shown in FIGS. 1-2 and the mouth of the guide is funnel-shaped, permitting an easy insertion of the plunger as well as preventing buckling of the plunger.
According to a microliter syringe so constructed, even if during the insertion of the plunger 8 into the guide the plunger is displaced slantwise as shown in FIG. 4, the guide is pliably bent at a flexible section 9 and the plunger 8 can be smoothly pushed into the bore of the syringe body without any appreciable resistance. Furthermore, even if the plunger is pliably bent, the guide is correspondingly bent so that the plunger does not buckle. And any tendency for the plunger to be eventually bent can also be avoided due to the pliable or flexible nature of the hollow guide.
When the plunger is manually pushed down to the zero position on the scale and abutted against the penetrating end of the cannula, a manual depressing force is concentrated on the exposed portion of the plunger. Since, however, the length 1 so defined between the upper end surface of the plunger and the lower end surface of the knob is not more than several millimeters or preferably of the order of about 1 mm, the plunger does not buckle even if any slant force is applied to the plunger. If any guide is not mounted to the syringe body through the flange, a space necessary for a manual operation is required between the flange 5 and the knob and, consequently, the exposed surface of the plunger as defined between the flange and the knob is made longer. In this case, if further manual depressing force is applied to the knob, the plunger tends to be eventually bent or buckle at the upper end surface of the flange 5. According to this invention, a length between the knob 10 and the guide 7 can be reduced to about 1 mm and a resistance to buckling is further increased. Furthermore, any eventual bending or plastic deformation as well as buckling of the plunger can be avoided due to the pliable section 9 of the guide.
The plunger 8 and guide 7 can be, after removal from the syringe body, cleaned separately. The guide is easy to handle during cleaning, since it is detachably mounted to the syringe body through the flange.
As explained above, according to this invention the flexible or pliable guide is mounted to the syringe body. This arrangement can prevent any eventual bending or buckling of the plunger as occurring when the plunger is inserted into the syringe body and even when the inseition is nearly completed. Furthermore, the arrangement provides a longer space between the flange and the knob due to the presence. of the guide so that the plunger can be easily manipulated. As the hollow guide is simple in construction and is removably mounted, for example, through the flange, to the syringe body, a cleaning operation can be easily carried out. Consequently, practical advantages are obtained according to this invention.
It is to be noted that the guide can be fixedly secured to the syringe body if circumstances permit.
What is claimed is:
l. A microliter syringe for dispensing small, arcuately measured quantities of fluid specimens, comprising:
a syringe body having a small bore therethrough;
a cannula mounted on one end of said body and communicating with the said bore;
an elongated plunger of bendable material extending slidably in said bore, the diameters of said plunger and bore being of the order of 0.5 mm whereby said plunger is readily bendable; and
a guide means mounted on the other end of said body with said plunger extending slidably therethrough, said guide means being readily bendable in response to lateral forces on said plunger outwardly of said guide whereby said guide means prevents kinking of said plunger upon operation of said syringe with the portion of said plunger in said bore being angularly related to the portion thereof extending outwardly of said body.
2. A microliter syringe according to claim 1 in which said guide means is more readily bendable at its free end portion than at its base portion.
3. A microliter syringe according to claim 2 in which said guide means is thinner at its free end portion than at its base portion.
4. A microliter syringe according to claim 1 in which said guide means is made of a flexible plastic resin.
5. A microliter syringe according to claim 1 in which said guide means is substantially cylindrical in shape.
6. A microliter syringe according to claim 1 in which a knob is mounted on the free end of the plunger; a flange is mounted on the said other end of the syringe body; and wherein the distance between the flange and the knob is sufficient for a human finger to be inserted therebetween; and the distance between the knob and the upper end of the guide means when the plunger is pushed down to its limit is about 1 mm.
7. A microliter syringe according to claim 1 in which said guide means is provided with a funnel-shaped mouth at its outer end for guiding said plunger therethrough.

Claims (7)

1. A microliter syringe for dispensing small, arcuately measured quantities of fluid specimens, comprising: a syringe body having a small bore therethrough; a cannula mounted on one end of said body and communicating with the said bore; an elongated plunger of bendable material extending slidably in said bore, the diameters of said plunger and bore being of the order of 0.5 mm whereby said plunger is readily bendable; and a guide means mounted on the other end of said body with said plunger extending slidably therethrough, said guide means being readily bendable in response to lateral forces on said plunger outwardly of said guide whereby said guide means prevents kinking of said plunger upon operation of said syringe with the portion of said plunger in said bore being angularly related to the portion thereof extending outwardly of said body.
2. A microliter syringe according to claim 1 in which said guide means is more readily bendable at its free end portion than at its base portion.
3. A microliter syringe according to claim 2 in which said guide means is thinner at its free end portion than at its base portion.
4. A microliter syringe according to claim 1 in which said guide means is made of a flexible plastic resin.
5. A microliter syringe according to claim 1 in which said guide means is substantially cylindrical in shape.
6. A microliter syringe according to claim 1 in which a knob is mounted on the free end of the plunger; a flange is mounted on the said other end of the syringe body; and wherein the distance between the flange and the knob is sufficient for a human finger to be inserted therebetween; and the distance between the knob and the upper end of the guide means when the plunger is pushed down to its limit is about 1 mm.
7. A microliter syringe according to claim 1 in which said guide means is provided with a funnel-shaped mouth at its outer end for guiding said plunger therethrough.
US454838A 1973-03-29 1974-03-26 Microliter syringe for dispensing small, accurately measured quantities of fluid specimens Expired - Lifetime US3923207A (en)

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Cited By (14)

* Cited by examiner, † Cited by third party
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US4664655A (en) * 1986-03-20 1987-05-12 Norman Orentreich High viscosity fluid delivery system
US4758234A (en) * 1986-03-20 1988-07-19 Norman Orentreich High viscosity fluid delivery system
US5454491A (en) * 1993-08-30 1995-10-03 World Precision Instruments, Inc. Non-metallic precision fluid transfer devices
US6120481A (en) * 1998-12-21 2000-09-19 Becton, Dickinson And Company Scale on a plastic syringe
US20060002986A1 (en) * 2004-06-09 2006-01-05 Smithkline Beecham Corporation Pharmaceutical product
US20060016830A1 (en) * 2004-06-09 2006-01-26 Smithkline Beecham Corporation Apparatus and method for pharmaceutical production
US20070287958A1 (en) * 2004-01-12 2007-12-13 Iscience Surgical Corporation Injector for Viscous Materials
US20080262435A1 (en) * 2007-04-23 2008-10-23 Ultimed Inc. Low-dosage syringe
US20090247955A1 (en) * 2008-03-27 2009-10-01 Iscience Interventional Corporation Microliter injector
US8101244B2 (en) 2004-06-09 2012-01-24 Smithkline Beecham Corporation Apparatus and method for producing or processing a product or sample
US10232364B2 (en) * 2013-11-29 2019-03-19 Yamaha Hatsudoki Kabushiki Kaisha Aspiration tip
US11090445B2 (en) 2017-06-16 2021-08-17 Credence Medsystems, Inc. System and method for safety syringe
US11419991B2 (en) 2018-11-13 2022-08-23 Credence Medsystems, Inc. System and method for microdose injection
US11883635B2 (en) 2020-06-17 2024-01-30 Credence MedSystems System and method for microdose injection

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US4493704A (en) * 1982-11-29 1985-01-15 Oximetrix, Inc. Portable fluid infusion apparatus

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US3216616A (en) * 1964-03-02 1965-11-09 Jr Homer Blankenship Syringe with upper and lower bores
US3417904A (en) * 1966-01-11 1968-12-24 Fischer & Porter Co Syringe and method of making same
US3537453A (en) * 1968-03-14 1970-11-03 Drummond Instr Co Microliter syringe having disposable parts

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Publication number Priority date Publication date Assignee Title
US3216616A (en) * 1964-03-02 1965-11-09 Jr Homer Blankenship Syringe with upper and lower bores
US3417904A (en) * 1966-01-11 1968-12-24 Fischer & Porter Co Syringe and method of making same
US3537453A (en) * 1968-03-14 1970-11-03 Drummond Instr Co Microliter syringe having disposable parts

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4758234A (en) * 1986-03-20 1988-07-19 Norman Orentreich High viscosity fluid delivery system
US4664655A (en) * 1986-03-20 1987-05-12 Norman Orentreich High viscosity fluid delivery system
US5454491A (en) * 1993-08-30 1995-10-03 World Precision Instruments, Inc. Non-metallic precision fluid transfer devices
US6120481A (en) * 1998-12-21 2000-09-19 Becton, Dickinson And Company Scale on a plastic syringe
US20070287958A1 (en) * 2004-01-12 2007-12-13 Iscience Surgical Corporation Injector for Viscous Materials
US7967772B2 (en) 2004-01-12 2011-06-28 Iscience Interventional Corporation Injector for viscous materials
US8252234B2 (en) 2004-06-09 2012-08-28 Smithkline Beecham Corporation Apparatus for producing a pharmaceutical product
US20060016830A1 (en) * 2004-06-09 2006-01-26 Smithkline Beecham Corporation Apparatus and method for pharmaceutical production
US8101244B2 (en) 2004-06-09 2012-01-24 Smithkline Beecham Corporation Apparatus and method for producing or processing a product or sample
US8122849B2 (en) 2004-06-09 2012-02-28 Smithkline Beecham Corporation Apparatus and method for producing a pharmaceutical product
US20060002986A1 (en) * 2004-06-09 2006-01-05 Smithkline Beecham Corporation Pharmaceutical product
US20080262435A1 (en) * 2007-04-23 2008-10-23 Ultimed Inc. Low-dosage syringe
US8529521B2 (en) * 2007-04-23 2013-09-10 Ultimed Inc. Low-dosage syringe
US20090247955A1 (en) * 2008-03-27 2009-10-01 Iscience Interventional Corporation Microliter injector
US10232364B2 (en) * 2013-11-29 2019-03-19 Yamaha Hatsudoki Kabushiki Kaisha Aspiration tip
US11090445B2 (en) 2017-06-16 2021-08-17 Credence Medsystems, Inc. System and method for safety syringe
US11964141B2 (en) 2017-06-16 2024-04-23 Credence Medsystems, Inc. System and method for safety syringe
US11419991B2 (en) 2018-11-13 2022-08-23 Credence Medsystems, Inc. System and method for microdose injection
US11883635B2 (en) 2020-06-17 2024-01-30 Credence MedSystems System and method for microdose injection

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JPS49140987U (en) 1974-12-04
GB1451826A (en) 1976-10-06
JPS5314227Y2 (en) 1978-04-15
CH580277A5 (en) 1976-09-30

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