US4112066A - Breath freshener composition and method - Google Patents
Breath freshener composition and method Download PDFInfo
- Publication number
- US4112066A US4112066A US05/697,887 US69788776A US4112066A US 4112066 A US4112066 A US 4112066A US 69788776 A US69788776 A US 69788776A US 4112066 A US4112066 A US 4112066A
- Authority
- US
- United States
- Prior art keywords
- sub
- calcium hydroxide
- hrs
- weight
- magnesium hydroxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
Definitions
- the present invention relates to a breath freshener composition which includes as its active ingredient calcium hydroxide or combinations of calcium hydroxide and/or magnesium hydroxide and/or copper gluconate and to a method for inhibiting bad breath employing such compositions.
- U.S. Pat. No. 2,926,121 to Hobbs et al discloses an antacid composition which contains a fully hydrated alumina gel as the primary ingredient and which may contain other antacids, namely, magnesium hydroxide, magnesium trisilicate or calcium carbonate.
- U.S. Pat. Nos. 2,894,876 and 3,044,939 to Scanlan et al disclose oral deodorant candy tablets and chewing gum containing copper gluconate preferably in combination with a glyceride fat or oil.
- U.S. Pat. Nos. 3,565,933 and 3,655,868 to Vagenius disclose an oral deodorant containing a water soluble reaction product of copper gluconate and glycine, the latter U.S. Pat. No. 3,655,868 also including ferrous gluconate.
- calcium hydroxide and “magnesium hydroxide” will also encompass calcium oxide and magnesium oxide, respectively.
- the calcium hydroxide and the various combinations set out above may be employed in various comestibles such as pressed candies or mints, boiled candies or drops as well as in dental creams or powders, mouth washes, chewing gums and the like.
- the calcium hydroxide where employed alone without magnesium hydroxide or copper gluconate, will be present in an amount within the range of from about 0.05 to about 1%, and preferably from about 0.1 to about 0.7% by weight of the comestible (regardless of the type).
- a unit dosage of candy (pressed or boiled), chewing gum, dental cream or mouth wash may contain from about 1 to about 10 mg, and preferably from about 2.5 to about 9.5 mg of calcium hydroxide. While amounts greater than 10 mg are effective, and may be employed, if desired, it has been found that amounts of calcium hydroxide greater than 10 mg may cause taste or flavor problems in a comestible.
- the calcium hydroxide may cause browning of the sugar.
- the calcium hydroxide may be employed in encapsulated form so as to prevent direct contact of wet sugar with the calcium hydroxide; in this case, the calcium hydroxide may be employed in amounts up to 1%.
- each of the calcium hydroxide and magnesium hydroxide may be present in an amount within the range of from about 1 to about 10 mg, and preferably from about 1 to about 5 mg, so as to provide a weight ratio of calcium hydroxide:magnesium hydroxide within the range of from about 0.1:1 to about 10:1, and preferably from about 0.5:1 to about 2:1.
- the combined weight of this combination will be from about 0.05 to about 1%, and preferably from about 0.15 to about 0.6% by weight of the comestible with the copper gluconate alone being from about 0.005 to about 0.01% of the comestible.
- the calcium hydroxide may be present in an amount within the range of from about 1 to about 10 mg, and preferably from about 1 to about 5 mg
- the copper gluconate may be present in an amount within the range of from about 0.01 to about 0.05 mg, and preferably from about 0.01 to about 0.04 mg so as to provide a weight ratio of copper gluconate:calcium hydroxide within the range of from about 0.05:1 to about 0.1:1, and preferably from about 0.06:1 to about 0.09:1.
- the combined weight of this combination will be from about 0.05 to about 1%, and preferably from about 0.15 to about 0.6% by weight of the comestible with the copper gluconate alone being from about 0.005 to about 0.01% by weight of the comestible.
- the magnesium hydroxide may be present in an amount within the range of from about 1 to about 10 mg, and preferably from about 1 to about 5 mg, while the copper gluconate may be present in an amount within the range of from about 0.01 to about 0.05 mg and preferably from about 0.01 to about 0.04 mg so as to provide a weight ratio of copper gluconate:magnesium hydroxide within the range of from about 0.05:1 to about 0.1:1, and preferably from about 0.06:1 to about 0.09:1.
- the combined weight of the combination will be from about 0.05 to about 2%, and preferably from about 0.15 to about 1.6% by weight of the comestible.
- the copper gluconate will be present in amounts within the range of from about 0.005 to about 0.01%, and preferably from about 0.007 to about 0.009% by weight of the comestible while each of the calcium hydroxide and magnesium hydroxide will be present in amounts within the range of from about 0.05 to about 1%, and preferably from about 0.15 to about 1% by weight.
- each of the calcium hydroxide and magnesium hydroxide may be present in an amount within the range of from about 1 to about 10 mg, and preferably from about 1 to about 5 mg, and the copper gluconate may be present in an amount within the range of from about 0.01 to about 0.05 mg, and preferably from about 0.01 to about 0.04 mg.
- magnesium hydroxide may be employed as a breath freshener in relatively small amounts in pressed or boiled candies within the range of from about 0.05 to about 0.6%, and preferably from about 0.1 to about 0.5% by weight of the candy.
- the fact that such small amounts of magnesium hydroxide are effective in inhibiting formation of malodors in the mouth is indeed surprising in view of the present use of about 1% by weight magnesium hydroxide in breath mints that have been marketed for several years.
- the comestible containing the calcium hydroxide and the various combinations set out above are particularly useful in inhibiting or preventing the onset of bad breath due to lack of saliva flow.
- the comestible of the invention may be administered in the morning after a night's sleep or after a nap or at any time during the day when one's mouth is dry.
- Saliva is collected (by stimulating with odorless and tasteless wax; Sun Oil Co.'s 1290 Y wax) in a wide mouth graduated tapered bottom test tube.
- the volume of saliva collected depends on the amount needed and varies from 15 to 25 ml. Three mls. aliquots are transferred into 7 drams vials which are sealed with Teflon-rubber lined screw caps to provide an air-tight seal.
- the sample is stored either at room temperature or at 98°-99° F. If an additive is required in a sample, the additive is weighed in the vial prior to introduction of the saliva sample.
- a Hamilton gas tight syringe with a Teflon coated plunger and a hypodermic needle are used to remove 10 ml aliquots of headspace for gas chromatographic sulfur analysis. This is achieved by means of a 3-4 mm hole in the plastic cap. The cap is then opened, the odor is evaluated, the Teflon-rubber liner is replaced with a new liner and the vial is recapped for further storage.
- the subject's mouth air Prior to saliva collection, the subject's mouth air is sampled and analyzed for sulfur by gas chromatography. Ten ml of mouth air is withdrawn from the subject's mouth after breathing only through the nose with the mouth closed for one minute, then a clean polyethylene tube is attached to the Luer tip of the syringe, which is described above, and inserted quickly in the mouth, the subject is asked to stop breathing, and the sample (10 cc) is quickly collected from the oral cavity. The tube is quickly replaced with a hypodermic needle and the entire sample is injected on the gas chromatographic column directly.
- the individual sulfur compounds are separated on a 24 ft ⁇ 1/8 in. Teflon column packed with 20% carbowax 20 M on 60-80 mesh chromosorb W (acid washed and DMCS treated).
- the analyses are performed at isothermal column temperature of 60° C.
- the temperature of the injection port is 150°-160° C and the temperature of the detector is 170°-180° C.
- the pressures and flow rates of the high purity gases are: N 2 carrier gas (40 psig) -- 30 cc/min., H 2 (40 psig) - 180 cc. min., air (40 psig) -- 45 cc/min., O 2 (40 psig) -- 35 cc/min. At these parameters the following peaks and retention times are given:
- the peak areas of the sulfur compounds are measured by the "height ⁇ width at 1/2 height" method.
- the total sulfur peak areas is obtained by summing individual peak areas after adjusting for attenuation scale.
- Ethanol solutions containing both (CH 3 ) 2 S, and (CH 3 S) 2 are injected in amounts to give 1.2 ng to 120 ng total sulfur concentration per injection.
- the peak areas are measured and a log log graph is made of areas vs. concentration. Concentration of sulfur in the samples is estimated from the graph.
- the odor of putrified saliva is simulated in water by adding 1 ul of air saturated with methyl mercaptan to 5 ml of distilled water.
- Prolonged storage of saliva at 98° F does not produce an appreciable increase in sulfur concentration, and a drop in the strength of the putrefied odor is noted.
- concentration of sulfur in the headspace and the putrefied odor continually increase. Room temperature storage is used for most of the samples studies to date, since it provides for a better comparison between the samples in the long range.
- compositions are effective in inhibiting onset of bad breath.
- a pressed mint is prepared from the following formulation:
- a boiled drop is prepared from the following formulation:
- a mouth wash is prepared from the following formulation:
- a dental cream is prepared having the following composition:
- a chewing gum is prepared from the following formulation:
- a pressed mint is prepared from the following formulation:
- a boiled drop is prepared from the following formulation:
- a mouth wash is prepared from the following formulation:
- a dental cream is prepared having the following composition:
- a chewing gum is prepared from the following formulation:
- a pressed mint is prepared from the following formulation:
- a boiled drop is prepared from the following formulation:
- a mouth wash is prepared from the following formulation:
- a dental cream is prepared having the following composition:
- a chewing gum is prepared from the following formulation:
- a pressed mint is prepared from the following formulation:
- a boiled drop is prepared from the following formulation:
- a mouth wash is prepared from the following formulation:
- a dental cream is prepared having the following composition:
Abstract
A breath freshener composition is provided which may be in the form of a comestible, such as a pill, powder, tablet, pressed candy or mint, boiled candy, mouthwash, dental cream, chewing gum and the like, and which includes as its active ingredient calcium hydroxide alone or combinations of calcium hydroxide and magnesium hydroxide or combinations of magnesium hydroxide and/or calcium hydroxide with copper gluconate. In addition, a method is provided for inhibiting bad breath wherein calcium hydroxide alone or any of the above combinations is employed.
Description
The present invention relates to a breath freshener composition which includes as its active ingredient calcium hydroxide or combinations of calcium hydroxide and/or magnesium hydroxide and/or copper gluconate and to a method for inhibiting bad breath employing such compositions.
Bad breath or mouth malodor is generally attributed to stale or putrified saliva. It has also been shown that mouth malodor is associated with sulfur compounds which are generated by decomposition of three amino acids in the saliva, namely, methionine, cystine and cysteine, to produce hydrogen sulfide, methyl mercaptan and dimethyl sulfide and sometimes dimethyl disulfide; for example see Tonzetich, "Direct Gas Chromatographic Analysis of Sulphur Compounds in Mouth Air in Man," Arch Oral Biol., Vol. 16, pp. 587-597, 1971; Tonzetich et al, "Evaluation of Volatile Odoriferous Components of Saliva," Arch Oral Biol., Vol. 9 pp. 39-45, 1964; and Tonzetich et al, "Odour Product by Human Salivary Fractions and Plaque," Arch Oral Biol., Vol. 14, pp. 815-827, 1969.
U.S. Pat. No. 2,926,121 to Hobbs et al discloses an antacid composition which contains a fully hydrated alumina gel as the primary ingredient and which may contain other antacids, namely, magnesium hydroxide, magnesium trisilicate or calcium carbonate.
British Patent Specification No. 294,299, U.S. Pat. Nos. 2,525,072 to Kearby, 1,630,763 to Raymer and Australian Patent Specification 131,394 disclose chewing gum compositions which include magnesium oxide or hydroxide or calcium carbonate.
U.S. Pat. Nos. 2,894,876 and 3,044,939 to Scanlan et al disclose oral deodorant candy tablets and chewing gum containing copper gluconate preferably in combination with a glyceride fat or oil.
U.S. Pat. Nos. 3,565,933 and 3,655,868 to Vagenius disclose an oral deodorant containing a water soluble reaction product of copper gluconate and glycine, the latter U.S. Pat. No. 3,655,868 also including ferrous gluconate.
It has now been found that bad breath due to mouth malodor is effectively inhibited by comestibles containing calcium hydroxide alone or combinations of calcium hydroxide with magnesium hydroxide, combinations of calcium hydroxide and copper gluconate, combinations of magnesium hydroxide and copper gluconate, and combinations of calcium hydroxide, magnesium hydroxide and copper gluconate.
In fact, it has been found that a combination of calcium hydroxide and magnesium hydroxide, and a combination of magnesium hydroxide and calcium gluconate are more effective in inhibiting bad breath than the additive effect of either component of each combination alone thereby indicating that such combinations are synergistic combinations. Furthermore, it has been found that the effectiveness of copper gluconate in inhibiting bad breath can be greatly increased by employing it in combinations containing calcium hydroxide.
It will be appreciated that the terms "calcium hydroxide" and "magnesium hydroxide" will also encompass calcium oxide and magnesium oxide, respectively.
The calcium hydroxide and the various combinations set out above may be employed in various comestibles such as pressed candies or mints, boiled candies or drops as well as in dental creams or powders, mouth washes, chewing gums and the like.
The calcium hydroxide, where employed alone without magnesium hydroxide or copper gluconate, will be present in an amount within the range of from about 0.05 to about 1%, and preferably from about 0.1 to about 0.7% by weight of the comestible (regardless of the type). Thus, for example, a unit dosage of candy (pressed or boiled), chewing gum, dental cream or mouth wash may contain from about 1 to about 10 mg, and preferably from about 2.5 to about 9.5 mg of calcium hydroxide. While amounts greater than 10 mg are effective, and may be employed, if desired, it has been found that amounts of calcium hydroxide greater than 10 mg may cause taste or flavor problems in a comestible.
Where the calcium hydroxide is employed in confections containing sugar prepared via wet techniques such as boiled candies, the calcium hydroxide may cause browning of the sugar. In such case, it is preferred to use amounts of calcium hydroxide of less than about 0.5% and preferably less than about 0.3% by weight of the confection. Alternatively, the calcium hydroxide may be employed in encapsulated form so as to prevent direct contact of wet sugar with the calcium hydroxide; in this case, the calcium hydroxide may be employed in amounts up to 1%.
Where the calcium hydroxide is employed in combination with magnesium hydroxide, the combined weight of this combination will be from about 0.05 to about 2%, and preferably from about 0.15 to about 1.5% by weight of the comestible. Thus, for example, each of the calcium hydroxide and magnesium hydroxide may be present in an amount within the range of from about 1 to about 10 mg, and preferably from about 1 to about 5 mg, so as to provide a weight ratio of calcium hydroxide:magnesium hydroxide within the range of from about 0.1:1 to about 10:1, and preferably from about 0.5:1 to about 2:1.
Where the calcium hydroxide is employed in combination with copper gluconate, the combined weight of this combination will be from about 0.05 to about 1%, and preferably from about 0.15 to about 0.6% by weight of the comestible with the copper gluconate alone being from about 0.005 to about 0.01% of the comestible. Thus, for example, the calcium hydroxide may be present in an amount within the range of from about 1 to about 10 mg, and preferably from about 1 to about 5 mg, while the copper gluconate may be present in an amount within the range of from about 0.01 to about 0.05 mg, and preferably from about 0.01 to about 0.04 mg so as to provide a weight ratio of copper gluconate:calcium hydroxide within the range of from about 0.05:1 to about 0.1:1, and preferably from about 0.06:1 to about 0.09:1.
Where the magnesium hydroxide is employed in combination with copper gluconate, the combined weight of this combination will be from about 0.05 to about 1%, and preferably from about 0.15 to about 0.6% by weight of the comestible with the copper gluconate alone being from about 0.005 to about 0.01% by weight of the comestible. Thus, for example, the magnesium hydroxide may be present in an amount within the range of from about 1 to about 10 mg, and preferably from about 1 to about 5 mg, while the copper gluconate may be present in an amount within the range of from about 0.01 to about 0.05 mg and preferably from about 0.01 to about 0.04 mg so as to provide a weight ratio of copper gluconate:magnesium hydroxide within the range of from about 0.05:1 to about 0.1:1, and preferably from about 0.06:1 to about 0.09:1.
Where the calcium hydroxide is employed in combination with both magnesium hydroxide and copper gluconate, the combined weight of the combination will be from about 0.05 to about 2%, and preferably from about 0.15 to about 1.6% by weight of the comestible. The copper gluconate will be present in amounts within the range of from about 0.005 to about 0.01%, and preferably from about 0.007 to about 0.009% by weight of the comestible while each of the calcium hydroxide and magnesium hydroxide will be present in amounts within the range of from about 0.05 to about 1%, and preferably from about 0.15 to about 1% by weight. Thus, for example, each of the calcium hydroxide and magnesium hydroxide may be present in an amount within the range of from about 1 to about 10 mg, and preferably from about 1 to about 5 mg, and the copper gluconate may be present in an amount within the range of from about 0.01 to about 0.05 mg, and preferably from about 0.01 to about 0.04 mg.
In an alternative embodiment of the present invention, magnesium hydroxide may be employed as a breath freshener in relatively small amounts in pressed or boiled candies within the range of from about 0.05 to about 0.6%, and preferably from about 0.1 to about 0.5% by weight of the candy. The fact that such small amounts of magnesium hydroxide are effective in inhibiting formation of malodors in the mouth is indeed surprising in view of the present use of about 1% by weight magnesium hydroxide in breath mints that have been marketed for several years.
In use, the comestible containing the calcium hydroxide and the various combinations set out above are particularly useful in inhibiting or preventing the onset of bad breath due to lack of saliva flow. Thus, for example, the comestible of the invention may be administered in the morning after a night's sleep or after a nap or at any time during the day when one's mouth is dry.
The effectiveness of the calcium hydroxide and the various combinations of the invention in inhibiting formation of malodorous sulfur compounds in saliva is shown by the following.
Saliva is collected (by stimulating with odorless and tasteless wax; Sun Oil Co.'s 1290 Y wax) in a wide mouth graduated tapered bottom test tube. The volume of saliva collected depends on the amount needed and varies from 15 to 25 ml. Three mls. aliquots are transferred into 7 drams vials which are sealed with Teflon-rubber lined screw caps to provide an air-tight seal. The sample is stored either at room temperature or at 98°-99° F. If an additive is required in a sample, the additive is weighed in the vial prior to introduction of the saliva sample. A Hamilton gas tight syringe with a Teflon coated plunger and a hypodermic needle are used to remove 10 ml aliquots of headspace for gas chromatographic sulfur analysis. This is achieved by means of a 3-4 mm hole in the plastic cap. The cap is then opened, the odor is evaluated, the Teflon-rubber liner is replaced with a new liner and the vial is recapped for further storage.
Prior to saliva collection, the subject's mouth air is sampled and analyzed for sulfur by gas chromatography. Ten ml of mouth air is withdrawn from the subject's mouth after breathing only through the nose with the mouth closed for one minute, then a clean polyethylene tube is attached to the Luer tip of the syringe, which is described above, and inserted quickly in the mouth, the subject is asked to stop breathing, and the sample (10 cc) is quickly collected from the oral cavity. The tube is quickly replaced with a hypodermic needle and the entire sample is injected on the gas chromatographic column directly.
Instrument: Micro-Tek MT-220 gas chromatograph with solic state electrometers, and 750 V power supply, a flame photometric detector with 394 nm filter. The dual solid stage electrometer enables monitoring of the photomeric and flame ionization detectors output simultaneously. The recorder is Sargent's Model SRLG, at 1 mv span and 0.5 inch/min. chart speed.
The individual sulfur compounds are separated on a 24 ft × 1/8 in. Teflon column packed with 20% carbowax 20 M on 60-80 mesh chromosorb W (acid washed and DMCS treated). The analyses are performed at isothermal column temperature of 60° C. The temperature of the injection port is 150°-160° C and the temperature of the detector is 170°-180° C. The pressures and flow rates of the high purity gases are: N2 carrier gas (40 psig) -- 30 cc/min., H2 (40 psig) - 180 cc. min., air (40 psig) -- 45 cc/min., O2 (40 psig) -- 35 cc/min. At these parameters the following peaks and retention times are given:
______________________________________
Peak Retention Time
______________________________________
Air 1.8 - 1.9 mins.
H.sub.2 S 2.2 - 2.4 mins.
CH.sub.3 SH 3.5 - 3.7 mins.
(CH.sub.3).sub.2 S
4.7 - 4.9 mins.
SO.sub.2 6.6 - 6.8 mins.
(CH.sub.3 S).sub.2
28.6 - 28.9 mins.
______________________________________
The peak areas of the sulfur compounds are measured by the "height × width at 1/2 height" method. The total sulfur peak areas is obtained by summing individual peak areas after adjusting for attenuation scale.
Ethanol solutions containing both (CH3)2 S, and (CH3 S)2 (at concentrations ranging from 10. ppm of each to 100 ppm of each) are injected in amounts to give 1.2 ng to 120 ng total sulfur concentration per injection. The peak areas are measured and a log log graph is made of areas vs. concentration. Concentration of sulfur in the samples is estimated from the graph.
a. After incubation of 1-2 hours at 98°-100° F, whole saliva samples shows distinct putrification and appreciable increase of concentration of sulfur in the headspace. In fresh saliva, the concentration of sulfur in the headspace ranges from 0 to 0.5 ng and in samples incubated for 1 1/2 hours at 98° F it ranges from 3.0 to 12.0 ng.
b. After incubation of saliva samples at room temperature the concentration of sulfur increases gradually during the first 3 hours, but dramatic increase in both sulfur concentration and putrefaction is noted after 4 hours.
c. The odor of putrified saliva is simulated in water by adding 1 ul of air saturated with methyl mercaptan to 5 ml of distilled water.
d. In addition to the three sulfur compounds (H2 S, (CH3)2 S, and CH3 SH) which are correlated with mouth malodor, another sulfur compound, dimethyl disulfide (CH3 S)2, is noted in headspace of all putrefied saliva samples which were stored for 24 hours or longer at room temperature and for 3 hours or longer at 98° F.
Prolonged storage of saliva at 98° F (i.e. 24 hours or longer) does not produce an appreciable increase in sulfur concentration, and a drop in the strength of the putrefied odor is noted. At room temperature storage the concentration of sulfur in the headspace and the putrefied odor continually increase. Room temperature storage is used for most of the samples studies to date, since it provides for a better comparison between the samples in the long range.
In addition to magnesium hydroxide, calcium hydroxide and copper gluconate are tested as additives in saliva samples and found to effectively retard putrefaction of saliva as seen from the low sulfur concentrations in the headspace and the low ratings on the unpleasant odor scale as can be seen from the following Table.
Table I
__________________________________________________________________________
Headspace Analyses and Odor Evaluation of
Whole Saliva Stored at Room Temperature and
Affect of Ca(OH).sub.2, Mg(OH).sub.2, Cu Gluconate
and Combinations Thereof
Odor Evaluation
Total Sulfur
(Magnitude of
Concentraton
Unpleasant Odor-
Age of in 10cc Head-
0 to 10
Additive Sample space 0=no unpleasant odor
Run No.
Amount Hrs & min.
(nanograms, ng)
10=very putrified odor)
__________________________________________________________________________
Control A
-- 2 hrs 35 min
1.30 6
Control B
Cu gluconate
2 hrs 50 min
1.68 2
(0.033 mg)
1 Ca(OH).sub.2
3 hrs 24 min
0.92 1
(10 mg)
2 Spray dried (SD)
3 hrs 10 min
1.32 2
Mg(OH).sub.2 (15 mg)
3 Ca(OH).sub.2 (10 mg)
3 hrs 54 min
0.67 1
+
Cu gluconate
(0.033 mg)
4 SD Mg(OH).sub.2
3 hrs 42 min
1.00 3
(15 mg)
+
Cu gluconate
(0.033 mg)
5 Ca(OH).sub.2
4 hrs 10 min
0.70 2
(5 mg)
Control C
-- 4 hrs 31 min
2.60 8
Control D
-- 18 hrs 32 min
7.30 10
6 Ca(OH).sub.2
19 hrs 50 min
0.22 0
(8.9 mg)
7 SD Mg(OH).sub.2
(9.7 mg) 19 hrs 21 min
2.3 1
Control E
Cu gluconate
19 hrs 5 min
5.50 2
8 Ca(OH).sub.2
20 hrs 8 min
0.40 0
(8.6 mg)
+
Cu gluconate
(0.07 mg)
9 SD Mg(OH).sub.2
(9.4 mg) 19 hrs 36 mn
0.83 0
+
Cu gluconate
(0.07 mg)
Control F
-- 44 hrs 35 min
470 10
Control G
Cu gluconate
46 hrs 17 min
2.9 2
(0.07 mg)
10 Ca(OH).sub.2
45 hrs 57 min
0 0
(8.9 mg)
11 SD Mg(OH).sub.2
44 hrs 52 min
2.2 1
(9.7 mg)
12 Ca(OH).sub.2
46 hrs 6 min
0 0
(8.6 mg)
+
Cu gluconate
(0.07 mg)
13 SD Mg(OH).sub.2
45 hrs 45 min
0.5 0
(9.4 mg)
+
Cu gluconate
(0.07 mg)
Control H
-- 52 hrs 11 min
330 10
Control I
Cu gluconate
53 hrs 17 min
380 10
(0.033 mg)
14 Ca(OH).sub.2
52 hrs 57 min
0.72 3
(10 mg)
15 Ca(OH).sub.2
54 hrs 9 min
0.50 3
(5 mg)
16 SD Mg(OH).sub.2
52 hrs 45 min
1.10 3
(15 mg)
17 Ca(OH).sub.2
54 hrs 0 min
0.89 3
(10 mg)
+
Cu gluconate
(0.033 mg)
18 SD Mg(OH).sub.2
53 hrs 49 min
0.54 3
(15 mg)
+
Cu gluconate
(0.033 mg)
Control J
-- 68 hrs 0 min
120 10
19 Ca(OH).sub.2
68 hrs 13 min
2.6 1
(2.4 mg)
20 Ca(OH).sub.2
68 hrs 21 min
0.61 1
(3.4 mg)
21 Mg (OH).sub.2
68 hrs 33 min
0.45 1
(9.7 mg)
22 SD Mg(OH).sub.2
68 hrs 42 min
0.52 1
(13.2 mg)
__________________________________________________________________________
SD Mg(OH).sub.2 is spray dried magnesium hydroxide on gum arabic. The
powder used contains 75% magnesium hydroxide.
ng =nanogram or one billionth of a gram
Table II
__________________________________________________________________________
Headspace Analyses And Odor Evaluation of
Whole Saliva Samples Stored at 98 F.
and Affect of Ca(OH).sub.2 and Mg(OH).sub.2 Thereon
Total Sulfur
Odor Evaluation
Concentration
(Magnitude of
Age of in 10cc Head-
Unpleasant Odor-
Additive Sample space 0=no unpleasant odor
Run No.
Amount Hrs & min
(nanograms, ng)
10=very putrified odor)
__________________________________________________________________________
Control K
-- 30 min 1.52 4
23 Ca(OH).sub.2
37 min 0.47 1
(9.4 mg)
24 SD Mg(OH).sub.2
45 min 1.52 1
(11.5 mg)
Control L
-- 2 hrs 2 min
3.3 10
25 Ca(OH).sub.2
2 hrs 18 min
0.39 1
(9.4 mg)
26 SD Mg(OH).sub.2
2 hrs 11 min
1.9 1
(11.5 mg)
Control M
-- 20 hrs 25 min
4.9 4
27 Ca(OH).sub.2
21 hrs 8 min
0 0
(9.4 mg)
28 SD Mg(OH).sub.2
20 hrs 45 min
2.0 1
(11.5 mg)
__________________________________________________________________________
SD Mg(OH).sub.2 is spray dried magnesium hydroxide on gum arabic. The
powder used contains 75% magnesium hydroxide.
ng=nanogram or one billionth of a gram
Table III
__________________________________________________________________________
Headspace Analysis and Odor Evaluation of
Saliva Centrifugate Stored at Room Temperature
and Affect of Ca(OH).sub.2 and Mg(OH).sub.2
and Combinations thereof thereon
Total Sulfur
Odor Evaluation
Concentration
(magnitude of
Age of in 10cc Head-
Unpleasant Odor
Additive Sample space 0=no unpleasant odor
Run No.
Amount Hrs & Min
(nanograms mg)
10=very putrified odor)
__________________________________________________________________________
Control N
-- 68 hrs 40 min
12.0 10
29 Ca(OH).sub.2
68 hrs 51 min
0.70 1
(1.7 mg)
30 Mg (OH).sub.2
69 hrs 2 min
1.80 2
(2.6 mg)
31 Ca(OH).sub.2
69 hrs 19 min
0.42 1/2
(1.8 mg)
+
Mg(OH).sub.2
(2.4 mg)
Control O
-- 10 days -- 10
32 Ca(OH).sub.2
10 days -- 31/2
(1.7 mg)
33 Mg(OH).sub.2
10 days -- 31/2
(2.6 mg)
34 Ca(OH).sub.2
10 days -- 2
(1.8 mg)
+
Mg(OH).sub.2
(2.4 mg)
Control P
-- 14 days -- 10
35 Ca(OH).sub. 2
14 days -- 7
(1.7 mg)
36 Mg(OH).sub.2
14 days -- 4
(2.6 mg)
37 Ca(OH).sub.2
14 days -- 2
(1.8 mg)
+
Mg(OH).sub.2
(2.4 mg)
__________________________________________________________________________
SD Mg(OH).sub.2 is spray dried magnesium hydroxide on gum arabic. The
powder used contains 75% magnesium hydroxide.
ng=nanogram or one billionth of a gram
The results in the above Table clearly show that calcium hydroxide alone; combinations of calcium hydroxide and magnesium hydroxide; combinations of calcium hydroxide and copper gluconate; combinations of magnesium hydroxide and copper gluconate; and magnesium hydroxide alone (at very low levels) are effective in inhibiting formation of sulfur compounds which contribute to mouth malodor.
The following examples illustrate the present invention without, however, limiting the same thereto. Each of the following compositions are effective in inhibiting onset of bad breath.
A pressed mint is prepared from the following formulation:
______________________________________ Mint granulation 98.1% Ca(OH).sub.2 0.5% Calcium stearate 1.0% Flavoring oil 0.4% ______________________________________
A boiled drop is prepared from the following formulation:
______________________________________
Sugar 74.3%
Corn Syrup 43° Be
25.0%
Ca(OH).sub.2 0.2%
Flavor 0.5%
______________________________________
A mouth wash is prepared from the following formulation:
______________________________________ Ca(OH).sub.2 5.00 gm Sodium chloride 8.00 gm Sodium bicarbonate 2.50 gm Glycerin 420.00 ml Alcohol 300.00 ml Menthol 0.24 gm Thymol 0.24 gm Methyl salicylate 0.70 ml Cinnamon oil 0.50 ml Eucalyptus oil 1.30 ml Cudbear tincture 16.00 ml Krameria tincture 8.00 ml Purified talc 20.00 gm Purified water sufficient to make 1,000.00 ml ______________________________________
A dental cream is prepared having the following composition:
______________________________________
Precipitated calcium carbonate
44.6%
Ca(OH).sub.2 0.4%
Sodium lauryl sulfate 1.5%
Glycerin 15.0%
Sorbitol (70% solution) 15.0%
Na saccharin 0.1%
Methyl p-hydroxy benzoate
0.1%
Na alginate 21 1.5%
Flavor 1.1%
Purified water 20.7%
______________________________________
A chewing gum is prepared from the following formulation:
______________________________________
Parts by Weight
______________________________________
Gum base 20
Sorbitol 10
Ca(OH).sub.2 0.5
Lecithin (softener) 0.5
Na Saccharin 0.1
Ca carbonate (filler)
10
Peppermint flavor oil
0.5
______________________________________
A pressed mint is prepared from the following formulation:
______________________________________ Mint granulation 97.6% Ca(OH).sub.2 0.5% Mg(OH).sub.2 0.5% Calcium stearate 1.0% Flavoring oil 0.4% ______________________________________
A boiled drop is prepared from the following formulation:
______________________________________
Sugar 73.5%
Corn Syrup 43° Be
25.0%
Ca(OH).sub.2 0.2%
Mg(OH).sub.2 0.8%
Flavor 0.5%
______________________________________
A mouth wash is prepared from the following formulation:
______________________________________ Magnesium hydroxide 2.50 gm Calcium hydroxide 2.50 gm Sodium chloride 8.00 gm Sodium bicarbonate 2.50 gm Glycerin 420.00 ml Alcohol 300.00 ml Menthol 0.24 gm Thymol 0.24 gm Methyl salicylate 0.70 ml Cinnamon oil 0.50 ml Eucalyptus oil 1.30 ml Cudbear tincture 16.00 ml Krameria tincture 8.00 ml Purified talc 20.00 gm Purified water sufficient to make 1,000.00 ml. ______________________________________
A dental cream is prepared having the following composition:
______________________________________
Precipitated calcium carbonate
44.0%
Ca(OH).sub.2 0.6%
Mg(OH).sub.2 0.4%
Sodium lauryl sulfate 1.5%
Glycerin 15.0%
Sorbitol (70% solution) 15.0%
Ca Saccharin (soluble) 0.1%
Methyl p-hydroxy benzoate
0.1%
Na alginate 21 1.5%
Flavor 1.1%
Purified water 20.7%
______________________________________
A chewing gum is prepared from the following formulation:
______________________________________
Parts by Weight
______________________________________
Gum Base 20
Ca(OH).sub.2 0.2
Mg(OH).sub.2 0.3
Sucrose 50
Sorbitol 10
Corn Syrup 19
______________________________________
A pressed mint is prepared from the following formulation:
______________________________________
Parts by Weight
______________________________________
Mint granulation 97.6
Ca(OH).sub.2 0.5
Cu gluconate 0.03
Calcium stearate 1.0
Flavoring oil 0.4
______________________________________
A boiled drop is prepared from the following formulation:
______________________________________
Parts by Weight
______________________________________
Sugar 73.5
Corn Syrup 43° Be
25.0
Ca(OH).sub.2 0.2
Copper gluconate 0.04
Flavor 0.5
______________________________________
A mouth wash is prepared from the following formulation:
______________________________________ Calcium hydroxide 5.00 gm Copper gluconate 0.3 gm Sodium chloride 8.00 gm Sodium bicarbonate 2.50 gm Glycerin 420.00 ml Alcohol 300.00 ml Menthol 0.24 gm Thymol 0.24 gm Methyl salicylate 0.70 ml Cinnamon oil 0.50 ml Eucalyptus oil 1.30 ml Cudbear tincture 16.00 ml Krameria tincture 8.00 ml Purified talc 20.00 gm Purified water sufficient to make 1,000.00 ml. ______________________________________
A dental cream is prepared having the following composition:
______________________________________
Parts by Weight
______________________________________
Precipitated calcium carbonate
44.0
Ca(OH).sub.2 0.6
Copper gluconate 0.03
Sodium lauryl sulfate 1.5
Glycerin 15.0
Sorbitol (70%) solution
15.0
Na Saccharin (soluble)
0.1
Methyl p-hydroxy benzoate
0.1
Na alginate 21 1.5
Flavor 1.1
Purified water 20.7
______________________________________
A chewing gum is prepared from the following formulation:
______________________________________
Parts by Weight
______________________________________
Gum base 20
Ca(OH).sub.2 0.2
Cu gluconate 0.03
Sucrose 50
Sorbitol 10
Corn Syrup 19
______________________________________
A pressed mint is prepared from the following formulation:
______________________________________ Mint granulation 98.1% Mg(OH).sub.2 0.5% Calcium stearate 1.0% Flavoring oil 0.4% ______________________________________
A boiled drop is prepared from the following formulation:
______________________________________
Parts by Weight
______________________________________
Sugar 73.0
Corn Syrup 43° Be
25.0
Ca(OH).sub.2a 0.2
Mg(OH).sub.2 0.6
Cu gluconate 0.03
Flavor 0.5
______________________________________
A mouth wash is prepared from the following formulation:
______________________________________ Magnesium hydroxide 5.00 gm Sodium chloride 8.00 gm Sodium bicarbonate 2.50 gm Glycerin 420.00 ml Alchohol 300.00 ml Menthol 0.24 gm Thymol 0.24 gm Methyl salicylate 0.70 ml Cinnamon oil 0.50 ml Eucalyptus oil 1.30 ml Cudbear tincture 16.00 ml Krameria tincture 8.00 ml Purified talc 20.00 gm Purified water sufficient to make 1,000.00 ml ______________________________________
A dental cream is prepared having the following composition:
______________________________________
Parts by Weight
______________________________________
Precipitated calcium carbonate
44.0
Ca(OH).sub.2 0.6
Mg(OH).sub.2 0.3
Cu gluconate 0.03
Sodium lauryl sulfate 1.5
Glycerin 15.0
Sorbitol (70% solution)
15.0
Saccharin (soluble) 0.1
Methyl p-hydroxy benzoate
0.1
Na alginate 21 1.5
Flavor 1.1
Purified water 20.7
______________________________________
Claims (13)
1. A breath freshener composition consisting essentially of calcium hydroxide dispersed in a non-toxic carrier.
2. The breath freshener composition as defined in claim 1 wherein said calcium hydroxide is present in an amount within the range of from about 0.05 to about 1% by weight.
3. The breath freshener composition as defined in claim 1 in the form of a comestible.
4. The breath freshener composition as defined in claim 3 wherein the comestible is a candy or chewing gum.
5. The breath freshener composition as defined in claim 3 wherein the comestible is a dental cream or mouth wash.
6. The breath freshener composition as defined in claim 1 further including magnesium hydroxide.
7. The breath freshener composition as defined in claim 6 wherein the calcium hydroxide is present in an amount within the range of from about 0.025 to about 1% by weight and the magnesium hydroxide is present in an amount within the range of from about 0.025 to about 1% by weight
8. The breath freshener composition as defined in claim 1 further including copper gluconate.
9. The breath freshener composition as defined in claim 8 wherein the calcium hydroxide is present in an amount within the range of from about 0.04 to about 0.99% by weight and the copper gluconate is present in an amount within the range of from about 0.005 to about 0.01% by weight.
10. The breath freshener composition as defined in claim 8 further including magnesium hydroxide in an amount within the range of from about 0.04 to about 0.99% by weight.
11. A method for inhibiting onset of bad breath which comprises chewing, applying to the teeth or rinsing in the mouth a composition as defined in claim 1.
12. A method for inhibiting onset of bad breath which comprises chewing, applying to the teeth or rinsing in the mouth a composition as defined in claim 6.
13. A method for inhibiting onset of bad breath which comprises chewing, applying to the teeth or rinsing in the mouth a composition as defined in claim 8.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/697,887 US4112066A (en) | 1976-06-21 | 1976-06-21 | Breath freshener composition and method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/697,887 US4112066A (en) | 1976-06-21 | 1976-06-21 | Breath freshener composition and method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US4112066A true US4112066A (en) | 1978-09-05 |
Family
ID=24802996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US05/697,887 Expired - Lifetime US4112066A (en) | 1976-06-21 | 1976-06-21 | Breath freshener composition and method |
Country Status (1)
| Country | Link |
|---|---|
| US (1) | US4112066A (en) |
Cited By (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2451192A1 (en) * | 1979-03-13 | 1980-10-10 | Asama Kasei Kk | CYCLODEXTRIN-CONTAINING BAD BREATH AGENT |
| US4303648A (en) * | 1980-04-07 | 1981-12-01 | Life Savers, Inc. | Breath freshener composition and method |
| US4327077A (en) * | 1981-05-29 | 1982-04-27 | Life Savers, Inc. | Compressed chewable antacid tablet and method for forming same |
| US4327076A (en) * | 1980-11-17 | 1982-04-27 | Life Savers, Inc. | Compressed chewable antacid tablet and method for forming same |
| US4409202A (en) * | 1980-04-07 | 1983-10-11 | Nabisco Brands, Inc. | Breath freshener composition and method |
| US4639368A (en) * | 1984-08-23 | 1987-01-27 | Farmacon Research Corporation | Chewing gum containing a medicament and taste maskers |
| US4765984A (en) * | 1986-01-22 | 1988-08-23 | Colgate-Palmolive Company | Stable single unit dose oral product |
| US5009893A (en) * | 1989-07-17 | 1991-04-23 | Warner-Lambert Company | Breath-freshening edible compositions of methol and a carboxamide |
| EP0471396A1 (en) * | 1990-08-16 | 1992-02-19 | Unilever N.V. | Dental compositions containing stabilized copper |
| EP0471397A1 (en) * | 1990-08-16 | 1992-02-19 | Unilever N.V. | Microbiologically stabilized phase for bicarbonate toothpaste manufacture |
| US5211940A (en) * | 1991-06-21 | 1993-05-18 | Lion Corporation | Transparent liquid oral composition |
| US5688491A (en) * | 1994-09-15 | 1997-11-18 | The Procter & Gamble Company | Oral compositions |
| US5698181A (en) * | 1994-12-09 | 1997-12-16 | Warner-Lambert Company | Breath-freshening edible compositions comprising menthol and an N-substituted-P-menthane carboxamide and methods for preparing same |
| US5958462A (en) * | 1997-05-23 | 1999-09-28 | Mclean; Linsey | Therapeutic bath salts and method of use |
| US6071500A (en) * | 1999-01-19 | 2000-06-06 | Thistle; Robert H. | Breath spray with tooth decay and halitosis prevention characteristics |
| US6083527A (en) * | 1998-11-05 | 2000-07-04 | Thistle; Robert | Breath mint with tooth decay and halitosis prevention characteristics |
| US6132701A (en) * | 1998-12-17 | 2000-10-17 | Perez; Narciso C. | Method for reducing oral malodor |
| US6210699B1 (en) | 1999-04-01 | 2001-04-03 | Watson Pharmaceuticals, Inc. | Oral transmucosal delivery of drugs or any other ingredients via the inner buccal cavity |
| WO2002041862A1 (en) * | 2000-11-21 | 2002-05-30 | Orix As | An oral hygiene preparation for inhibiting halitosis |
| EP1222860A2 (en) * | 2001-01-12 | 2002-07-17 | Roquette Frˬres | Confectionery with coarse structure for the treatment of halitosis |
| US20040247743A1 (en) * | 1997-09-18 | 2004-12-09 | Wm. Wrigley, Jr. Company | Chewing gum containing physiological cooling agents |
| US20050086225A1 (en) * | 2003-10-15 | 2005-04-21 | Xiaoming Cheng | Apparatus and method for searching a directory of stored items |
| US20060193909A1 (en) * | 2005-02-07 | 2006-08-31 | Stawski Barbara Z | Breath freshening pressed tablets and methods of making and using same |
| US20070031350A1 (en) * | 2005-08-02 | 2007-02-08 | Wm. Wrigley Jr. Company | Screening method for identification of compounds suitable for treatment of oral cavity malodor associated with consumption of garlic |
| US20070028935A1 (en) * | 2005-08-02 | 2007-02-08 | Wm. Wrigley Jr. Company | Screening method for the identification of compositions suitable for the treatment of oral cavity malodor associated with smoking a tobacco product |
| US20070054014A1 (en) * | 2005-02-07 | 2007-03-08 | Stawski Barbara Z | Breath freshening confectionery products and methods of making and using same |
| US20070166430A1 (en) * | 2004-04-20 | 2007-07-19 | Stawski Barbara Z | Breath freshening confectionery products and methods of making and using same |
| US20070248717A1 (en) * | 2004-02-26 | 2007-10-25 | Johnson Sonya S | Confections Containing a Blend of Physiological Cooling Agents |
| US20080008729A1 (en) * | 2006-07-07 | 2008-01-10 | The Procter & Gamble Company | Flavor oils with reduced sulfur content and use in oral care compositions |
| US20110024674A1 (en) * | 2009-07-28 | 2011-02-03 | Jacob Technology Product 1 S.L. | Coolant composition |
| WO2012100811A1 (en) * | 2011-01-24 | 2012-08-02 | Jacob Technology Product 1, S. L. | Coolant composition |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1817664A (en) * | 1928-10-26 | 1931-08-04 | Bernard B Badanes | Dentifrice |
| US2843521A (en) * | 1955-05-10 | 1958-07-15 | Olin Mathieson | Pharmaceutical preparations |
| US2894876A (en) * | 1956-07-17 | 1959-07-14 | American Chicle Co | Deodorant composition |
| US3728446A (en) * | 1971-01-11 | 1973-04-17 | Colgate Palmolive Co | Speckled dentifrice gel |
-
1976
- 1976-06-21 US US05/697,887 patent/US4112066A/en not_active Expired - Lifetime
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1817664A (en) * | 1928-10-26 | 1931-08-04 | Bernard B Badanes | Dentifrice |
| US2843521A (en) * | 1955-05-10 | 1958-07-15 | Olin Mathieson | Pharmaceutical preparations |
| US2894876A (en) * | 1956-07-17 | 1959-07-14 | American Chicle Co | Deodorant composition |
| US3728446A (en) * | 1971-01-11 | 1973-04-17 | Colgate Palmolive Co | Speckled dentifrice gel |
Cited By (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2451192A1 (en) * | 1979-03-13 | 1980-10-10 | Asama Kasei Kk | CYCLODEXTRIN-CONTAINING BAD BREATH AGENT |
| US4303648A (en) * | 1980-04-07 | 1981-12-01 | Life Savers, Inc. | Breath freshener composition and method |
| US4409202A (en) * | 1980-04-07 | 1983-10-11 | Nabisco Brands, Inc. | Breath freshener composition and method |
| US4327076A (en) * | 1980-11-17 | 1982-04-27 | Life Savers, Inc. | Compressed chewable antacid tablet and method for forming same |
| US4327077A (en) * | 1981-05-29 | 1982-04-27 | Life Savers, Inc. | Compressed chewable antacid tablet and method for forming same |
| US4639368A (en) * | 1984-08-23 | 1987-01-27 | Farmacon Research Corporation | Chewing gum containing a medicament and taste maskers |
| US4765984A (en) * | 1986-01-22 | 1988-08-23 | Colgate-Palmolive Company | Stable single unit dose oral product |
| AU598220B2 (en) * | 1986-01-22 | 1990-06-21 | Colgate-Palmolive Company, The | Stable single dose oral product |
| US5009893A (en) * | 1989-07-17 | 1991-04-23 | Warner-Lambert Company | Breath-freshening edible compositions of methol and a carboxamide |
| EP0471396A1 (en) * | 1990-08-16 | 1992-02-19 | Unilever N.V. | Dental compositions containing stabilized copper |
| EP0471397A1 (en) * | 1990-08-16 | 1992-02-19 | Unilever N.V. | Microbiologically stabilized phase for bicarbonate toothpaste manufacture |
| US5211940A (en) * | 1991-06-21 | 1993-05-18 | Lion Corporation | Transparent liquid oral composition |
| US5688491A (en) * | 1994-09-15 | 1997-11-18 | The Procter & Gamble Company | Oral compositions |
| US5698181A (en) * | 1994-12-09 | 1997-12-16 | Warner-Lambert Company | Breath-freshening edible compositions comprising menthol and an N-substituted-P-menthane carboxamide and methods for preparing same |
| US5958462A (en) * | 1997-05-23 | 1999-09-28 | Mclean; Linsey | Therapeutic bath salts and method of use |
| US20040247743A1 (en) * | 1997-09-18 | 2004-12-09 | Wm. Wrigley, Jr. Company | Chewing gum containing physiological cooling agents |
| US20070098842A1 (en) * | 1997-09-18 | 2007-05-03 | Wm. Wrigley Jr. Company | Chewing gum containing physiological cooling agents |
| US20080199565A1 (en) * | 1997-09-18 | 2008-08-21 | Wm. Wrigley Jr. Company | Chewing Gum Containing Physiological Cooling Agents |
| US7364761B2 (en) | 1997-09-18 | 2008-04-29 | Wm. Wrigley Jr. Company | Chewing gum containing physiological cooling agents and method of preparing |
| US7078066B2 (en) | 1997-09-18 | 2006-07-18 | Wm. Wrigley Jr. Company | Chewing gum containing physiological cooling agents and method of making |
| US20050019445A1 (en) * | 1997-09-18 | 2005-01-27 | Wm. Wrigley Jr. Company | Chewing gum containing physiological cooling agents |
| US6083527A (en) * | 1998-11-05 | 2000-07-04 | Thistle; Robert | Breath mint with tooth decay and halitosis prevention characteristics |
| US6132701A (en) * | 1998-12-17 | 2000-10-17 | Perez; Narciso C. | Method for reducing oral malodor |
| US6071500A (en) * | 1999-01-19 | 2000-06-06 | Thistle; Robert H. | Breath spray with tooth decay and halitosis prevention characteristics |
| US6210699B1 (en) | 1999-04-01 | 2001-04-03 | Watson Pharmaceuticals, Inc. | Oral transmucosal delivery of drugs or any other ingredients via the inner buccal cavity |
| WO2002041862A1 (en) * | 2000-11-21 | 2002-05-30 | Orix As | An oral hygiene preparation for inhibiting halitosis |
| EP1222860A3 (en) * | 2001-01-12 | 2004-01-02 | Roquette Frˬres | Confectionery with coarse structure for the treatment of halitosis |
| EP1222860A2 (en) * | 2001-01-12 | 2002-07-17 | Roquette Frˬres | Confectionery with coarse structure for the treatment of halitosis |
| US20050086225A1 (en) * | 2003-10-15 | 2005-04-21 | Xiaoming Cheng | Apparatus and method for searching a directory of stored items |
| US20070248717A1 (en) * | 2004-02-26 | 2007-10-25 | Johnson Sonya S | Confections Containing a Blend of Physiological Cooling Agents |
| US20070166430A1 (en) * | 2004-04-20 | 2007-07-19 | Stawski Barbara Z | Breath freshening confectionery products and methods of making and using same |
| US10085771B2 (en) | 2004-04-20 | 2018-10-02 | Wm. Wrigley Jr. Company | Breath freshening confectionery products and methods of making and using same |
| US8557323B2 (en) | 2004-04-20 | 2013-10-15 | Wm. Wrigley Jr. Company | Breath freshening confectionery products and methods of making and using same |
| US20070054014A1 (en) * | 2005-02-07 | 2007-03-08 | Stawski Barbara Z | Breath freshening confectionery products and methods of making and using same |
| US20060193909A1 (en) * | 2005-02-07 | 2006-08-31 | Stawski Barbara Z | Breath freshening pressed tablets and methods of making and using same |
| US8431150B2 (en) * | 2005-02-07 | 2013-04-30 | Wm. Wrigley Jr. Company | Breath freshening confectionery products and methods of making and using same |
| US20070031350A1 (en) * | 2005-08-02 | 2007-02-08 | Wm. Wrigley Jr. Company | Screening method for identification of compounds suitable for treatment of oral cavity malodor associated with consumption of garlic |
| US20070028935A1 (en) * | 2005-08-02 | 2007-02-08 | Wm. Wrigley Jr. Company | Screening method for the identification of compositions suitable for the treatment of oral cavity malodor associated with smoking a tobacco product |
| US7666685B2 (en) | 2005-08-02 | 2010-02-23 | Wm. Wrigley Jr. Company | Screening method for identification of compounds suitable for treatment of oral cavity malodor associated with consumption of garlic |
| US20080008729A1 (en) * | 2006-07-07 | 2008-01-10 | The Procter & Gamble Company | Flavor oils with reduced sulfur content and use in oral care compositions |
| US8007771B2 (en) | 2006-07-07 | 2011-08-30 | The Procter & Gamble Company | Flavors for oral compositions |
| US8865192B2 (en) * | 2006-07-07 | 2014-10-21 | The Procter & Gamble Co | Flavor oils with reduced sulfur content and use in oral care compositions |
| US20080008665A1 (en) * | 2006-07-07 | 2008-01-10 | The Procter & Gamble Company | Flavors for oral compositions |
| US8252199B2 (en) | 2009-07-28 | 2012-08-28 | Jacob Technology Product 1, SL | Coolant composition |
| US20110024674A1 (en) * | 2009-07-28 | 2011-02-03 | Jacob Technology Product 1 S.L. | Coolant composition |
| WO2012100811A1 (en) * | 2011-01-24 | 2012-08-02 | Jacob Technology Product 1, S. L. | Coolant composition |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4112066A (en) | Breath freshener composition and method | |
| Rosenberg et al. | Day‐long reduction of oral malodor by a two‐phase oil: water mouthrinse as compared to chlorhexidine and placebo rinses | |
| EP1909915B1 (en) | Screening method for the identification of compositions suitable for the treatment of oral cavity malodor associated with smoking a tobacco product | |
| FI84313C (en) | Oral composition and method to counteract bad breath | |
| US4303648A (en) | Breath freshener composition and method | |
| JPS6331442B2 (en) | ||
| US4409202A (en) | Breath freshener composition and method | |
| Wåler | The effect of zinc-containing chewing gum on volatile sulfur-containing compounds in the oral cavity | |
| BR0210524B1 (en) | Chewing Gum Composition and Method for Preparing a Chewing Gum | |
| JPS6251613A (en) | Dentifrice composition | |
| US4167559A (en) | Deodorizing breath composition | |
| KR100447428B1 (en) | Oral solution composition | |
| JPS61268259A (en) | Deodorant | |
| JPH0321003B2 (en) | ||
| JPH0366283B2 (en) | ||
| JPH01265964A (en) | Deodorizing agent | |
| JPH0366899B2 (en) | ||
| Porciani et al. | The effect of zinc lactate and magnolia bark extract added tablets on volatile sulfur-containing compounds in the oral cavity | |
| JPH0640868A (en) | Composition for oral cavity application | |
| JPH02200620A (en) | Deodorizing agent | |
| KR20010001476A (en) | Oral anti-halitosis preparations | |
| JP2551012B2 (en) | Oral composition | |
| JPH0370528B2 (en) | ||
| JPS63154614A (en) | Dentifrice composition | |
| JP2546263B2 (en) | Bad breath remover |