US4146619A - Siloxane toxicants - Google Patents

Siloxane toxicants Download PDF

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Publication number
US4146619A
US4146619A US05/802,013 US80201377A US4146619A US 4146619 A US4146619 A US 4146619A US 80201377 A US80201377 A US 80201377A US 4146619 A US4146619 A US 4146619A
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Prior art keywords
centistokes
polymer
dimethicone
toxicants
viscosity
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US05/802,013
Inventor
Myron J. Lover
Arnold J. Singer
Donald M. Lynch
William E. Rhodes, III
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Block Drug Co Inc
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Block Drug Co Inc
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Priority to US05/802,013 priority Critical patent/US4146619A/en
Priority to GB32135/77A priority patent/GB1604853A/en
Priority to PH21156A priority patent/PH15528A/en
Priority to AU36435/78A priority patent/AU515942B2/en
Priority to CH574678A priority patent/CH630238A5/en
Priority to MX10098378U priority patent/MX7145E/en
Priority to FR7816052A priority patent/FR2392604A1/en
Priority to BE188157A priority patent/BE867616A/en
Priority to CA304,437A priority patent/CA1108529A/en
Priority to DE19782823595 priority patent/DE2823595A1/en
Priority to JP6446378A priority patent/JPS545027A/en
Application granted granted Critical
Publication of US4146619A publication Critical patent/US4146619A/en
Anticipated expiration legal-status Critical
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Definitions

  • pediculicidal toxicants are Lindane (gamma benzene hexachloride), Malathion [(S-1,2-dicarbethoxyethyl)-O,O-dimethyl phosphorodithioate], synergized pyrethrins and Cuprex (a combination of tetrahydronaphthalene, copper oleate and acetone, the acetone not asserted to be active). Because of increased concern about the overall safety of some of the known ectoparasitic toxicants, the search for new, safe and effective pediculicides has intensified recently.
  • linear siloxane polymers exhibit pediculicidal and/or ovicidal activity. These compounds are known materials. For example, simethicone is widely used as an antiflatulent.
  • This invention relates to ectoparasiticidal toxicants and a method of controlling ectoparasites. More particularly, the invention relates to the use of linear siloxane polymers as toxicants for lice and/or their ova and to toxicant compositions containing such polymers.
  • the toxicants of this invention are the linear siloxane polymers having a viscosity of less than about 20,000 centistokes, preferably less than about 10,000 centistokes and most preferably about 1,000 centistokes or less.
  • the polymers are characterized by repeating units R 2 SiO in which each R is individually alkyl or aryl.
  • the R groups are usually methyl or a combination of methyl and phenyl, i.e., dimethicones (CTFA official name for dimethylpolysiloxanes) and phenyldimethicone.
  • the instant toxicants include simethicone which is a mixture of fully methylated linear siloxane polymers containing 93-99% dimethicone units stabilized with trimethylsiloxy [(CH 3 ) 3 SiO-] end blocking units and 4-4.5% silicon dioxide.
  • the polysiloxanes used in this invention are relatively inert pharmacologically, are chemically stable and are non-corrosive.
  • One or more of the toxic polymers of the present invention can be incorporated into an active toxicant composition which can be in the form of a liquid, powder, lotion, cream, gel or aerosol spray, or foam as the result of formulation with inert pharmaceutically acceptable carriers by procedures well known in the art.
  • an active toxicant composition which can be in the form of a liquid, powder, lotion, cream, gel or aerosol spray, or foam as the result of formulation with inert pharmaceutically acceptable carriers by procedures well known in the art.
  • Any pharmaceutically acceptable carrier, whether aqueous or not aqueous, which is inert to the active ingredient can be employed.
  • inert is meant that the carrier does not have a substantial detrimental effect on the pediculicidal or ovicidal toxicant activity of the active ingredient.
  • the active polymers are incorporated into the toxicant composition used to treat the substrate (human or animal) in need of such treatment, believed to be in need of such treatment, or desired to be prophylactically protected in an effective toxicant amount.
  • amount is meant the amount which will cause at least 50% of the ectoparasites exposed in the two minute immersion tests described below to die within 24 hours in the case of lice and within 2 weeks in case of the ova.
  • the minimum concentration of polymer required to provide an effective toxic amount varies considerably depending on the particular polymer, the particular inert pharmaceutically acceptable carrier being employed and any other ingredients which are present. Thus, in one case a 10% concentration may suffice, while in other cases, concentrations as high as 25% may be required to obtain an effective toxic dose.
  • the polymer will be used in concentrations of about 5 to 100% and most preferably at concentrations of about 10 to 100%.
  • the instant polymers can also be employed as an adjunct toxicant in a preparation which otherwise exhibits pediculicidal and/or ovicidal activity.
  • the term "effective toxic dose” means that amount which will increase the mortality rate by at least about 20% in the standard immersion tests.
  • Pediculicidal activity A 50 ml beaker is filled with tap water and allowed to come to room temperature (about 20° C.). Ten young adult male and ten young adult female lice (Pediculus humanus corporis) of the same age group and from the same stock colony are placed on a 2 ⁇ 2 cm coarse mesh path. The sample to be tested, maintained at room temperature, is shaken until homogeneous and placed into a 50 ml beaker. The mesh patch is placed into the sample immediately after pouring, allowed to submerge, and after two minutes is removed and immediately plunged into the beaker containing the tap water. The patch is vigorously agitated every ten seconds and after one minute the patch is removed and placed on paper toweling. The lice are then transferred to a 4 ⁇ 4 cm black corduroy cloth patch and this point of time is considered zero hours. Thereafter, the corduroy patch is placed in a petri dish which is covered and stored in a 30° C. holding chamber.
  • Ovicidal activity 15 adult, 5 to 10 day old, female lice (Pediculus humanus corporis) are placed on a 2 ⁇ 2 cm nylon mesh patch which is placed on a petri dish, covered and maintained in an incubator at 30° C. for 24 hours. The adult lice are then removed and the number of plump, viable eggs and shriveled non-fertile eggs on the patch are recorded. The sample to be tested, maintained at room temperature, is shaken until homogeneous and poured into a 50 ml beaker. Immediately after the pouring, the mesh patch is placed into the beaker, allowed to submerge, and after two minutes is removed and immediately plunged into a 50 ml beaker containing tap water at room temperature (about 24° C.).
  • the patch is vigorously agitated every ten seconds and after one minute, the patch is removed and placed on paper toweling for one minute. The patch is then placed in a petri dish which is covered and stored in the 30° C. incubator. Fourteen days following treatment, the number of hatched eggs and the number of shriveled or unhatched eggs is noted.
  • the pediculicidal and ovicidal activity of various toxicants of the instant invention were tested in the two minute immersion tests described above. The ratings set forth represent the percent mortality observed.
  • the polymers were evaluated in undiluted form (UD) or in a combination (C) containing 15 (w/w) percent polymer, 25% isopropanol and 60% aqueous carrier.
  • the viscosity range of 100-1000 centistokes for the dimethicones tested exhibit the highest pediculicidal activity below a 15% W/W concentration.
  • the one phenyldimethicone derivative tested displays equivalent activity but at a much lower viscosity value.

Abstract

Linear siloxane polymers have been found to exhibit pediculicidal and/or ovicidal activity.

Description

BACKGROUND OF THE INVENTION
There are only a relatively few pediculicides which are commercially available today. The most popular pediculicidal toxicants are Lindane (gamma benzene hexachloride), Malathion [(S-1,2-dicarbethoxyethyl)-O,O-dimethyl phosphorodithioate], synergized pyrethrins and Cuprex (a combination of tetrahydronaphthalene, copper oleate and acetone, the acetone not asserted to be active). Because of increased concern about the overall safety of some of the known ectoparasitic toxicants, the search for new, safe and effective pediculicides has intensified recently.
Many species of insects encase their ova in protective sheaths which are impregnable to most toxicants. The "gestation" period of the egg is often relatively long in comparison to the life cycle of the adult forms. Thus, an agent effective only against adults must persist for the lifetime of the developing ovum or must be reapplied as successive hatching occurs.
It has now been found that linear siloxane polymers exhibit pediculicidal and/or ovicidal activity. These compounds are known materials. For example, simethicone is widely used as an antiflatulent.
It is the object of this invention to provide new safe and effective toxicants for lice and their ova. This and other objects of the invention will become apparent to those skilled in the art from the following detailed description.
SUMMARY OF THE INVENTION
This invention relates to ectoparasiticidal toxicants and a method of controlling ectoparasites. More particularly, the invention relates to the use of linear siloxane polymers as toxicants for lice and/or their ova and to toxicant compositions containing such polymers.
DESCRIPTION OF THE PREFERRED EMBODIMENT
The toxicants of this invention are the linear siloxane polymers having a viscosity of less than about 20,000 centistokes, preferably less than about 10,000 centistokes and most preferably about 1,000 centistokes or less. The polymers are characterized by repeating units R2 SiO in which each R is individually alkyl or aryl. In most commercially available polysiloxanes, the R groups are usually methyl or a combination of methyl and phenyl, i.e., dimethicones (CTFA official name for dimethylpolysiloxanes) and phenyldimethicone. The instant toxicants include simethicone which is a mixture of fully methylated linear siloxane polymers containing 93-99% dimethicone units stabilized with trimethylsiloxy [(CH3)3 SiO-] end blocking units and 4-4.5% silicon dioxide. The polysiloxanes used in this invention are relatively inert pharmacologically, are chemically stable and are non-corrosive.
One or more of the toxic polymers of the present invention can be incorporated into an active toxicant composition which can be in the form of a liquid, powder, lotion, cream, gel or aerosol spray, or foam as the result of formulation with inert pharmaceutically acceptable carriers by procedures well known in the art. Any pharmaceutically acceptable carrier, whether aqueous or not aqueous, which is inert to the active ingredient can be employed. By inert is meant that the carrier does not have a substantial detrimental effect on the pediculicidal or ovicidal toxicant activity of the active ingredient.
The active polymers are incorporated into the toxicant composition used to treat the substrate (human or animal) in need of such treatment, believed to be in need of such treatment, or desired to be prophylactically protected in an effective toxicant amount. By such amount is meant the amount which will cause at least 50% of the ectoparasites exposed in the two minute immersion tests described below to die within 24 hours in the case of lice and within 2 weeks in case of the ova. The minimum concentration of polymer required to provide an effective toxic amount varies considerably depending on the particular polymer, the particular inert pharmaceutically acceptable carrier being employed and any other ingredients which are present. Thus, in one case a 10% concentration may suffice, while in other cases, concentrations as high as 25% may be required to obtain an effective toxic dose. Usually, the polymer will be used in concentrations of about 5 to 100% and most preferably at concentrations of about 10 to 100%.
The instant polymers can also be employed as an adjunct toxicant in a preparation which otherwise exhibits pediculicidal and/or ovicidal activity. In such preparations, the term "effective toxic dose" means that amount which will increase the mortality rate by at least about 20% in the standard immersion tests.
The two minute immersion tests referred to above is carried out as follows:
Pediculicidal activity: A 50 ml beaker is filled with tap water and allowed to come to room temperature (about 20° C.). Ten young adult male and ten young adult female lice (Pediculus humanus corporis) of the same age group and from the same stock colony are placed on a 2×2 cm coarse mesh path. The sample to be tested, maintained at room temperature, is shaken until homogeneous and placed into a 50 ml beaker. The mesh patch is placed into the sample immediately after pouring, allowed to submerge, and after two minutes is removed and immediately plunged into the beaker containing the tap water. The patch is vigorously agitated every ten seconds and after one minute the patch is removed and placed on paper toweling. The lice are then transferred to a 4×4 cm black corduroy cloth patch and this point of time is considered zero hours. Thereafter, the corduroy patch is placed in a petri dish which is covered and stored in a 30° C. holding chamber.
Ovicidal activity: 15 adult, 5 to 10 day old, female lice (Pediculus humanus corporis) are placed on a 2×2 cm nylon mesh patch which is placed on a petri dish, covered and maintained in an incubator at 30° C. for 24 hours. The adult lice are then removed and the number of plump, viable eggs and shriveled non-fertile eggs on the patch are recorded. The sample to be tested, maintained at room temperature, is shaken until homogeneous and poured into a 50 ml beaker. Immediately after the pouring, the mesh patch is placed into the beaker, allowed to submerge, and after two minutes is removed and immediately plunged into a 50 ml beaker containing tap water at room temperature (about 24° C.). The patch is vigorously agitated every ten seconds and after one minute, the patch is removed and placed on paper toweling for one minute. The patch is then placed in a petri dish which is covered and stored in the 30° C. incubator. Fourteen days following treatment, the number of hatched eggs and the number of shriveled or unhatched eggs is noted.
In both the pediculicidal and ovicidal two minute immersion tests, controls are run in identical manner to that described with room temperature (24° C.) tap water substituted for the sample to be tested. The results of the tests reported are net results.
The pediculicidal and ovicidal activity of various toxicants of the instant invention were tested in the two minute immersion tests described above. The ratings set forth represent the percent mortality observed. The polymers were evaluated in undiluted form (UD) or in a combination (C) containing 15 (w/w) percent polymer, 25% isopropanol and 60% aqueous carrier.
______________________________________                                    
                 % Mortality                                              
          Viscosity                                                       
          in       Pediculicidal                                          
                              Ovicidal                                    
Compound    centistokes                                                   
                       UD       C   UD     C                              
______________________________________                                    
Phenyldimethicone                                                         
            22.5       100      100  94    11                             
Dimethicone 100        100      100 100    72                             
Dimethicone 350        100      100 100    35                             
Dimethicone 900        100      100 100    52                             
Dimethicone 1,000      100      100 100    38                             
Dimethicone 12,000     100      100 100     0                             
______________________________________
The pediculicidal activity of various polysiloxanes as a function of concentration in 25% isopropanol, 7% Polysorbate 80 emulsifier, and water Q.S. was studied and the results are shown below.
______________________________________                                    
Phenyldimethicone 22.5 centistokes                                        
% W/W                   % Mortality                                       
15                      100                                               
13                      100                                               
11                      95                                                
9                       80                                                
7                       75                                                
5                       0                                                 
3                       0                                                 
1                       0                                                 
Dimethicone, 100 centistokes                                              
% W/W                   % Mortality                                       
15                      100                                               
13                      95                                                
11                      95                                                
9                       100                                               
7                       90                                                
5                       10                                                
3                       5                                                 
1                       5                                                 
Dimethicone, 350 centistokes                                              
% W/W                   % Mortality                                       
15                      100                                               
13                      100                                               
11                      100                                               
9                       100                                               
7                       95                                                
5                       85                                                
3                       25                                                
1                       0                                                 
Dimethicone, 900 centistokes                                              
% W/W                   % Mortality                                       
15                      100                                               
13                      100                                               
11                      100                                               
9                       85                                                
7                       70                                                
5                       20                                                
3                       20                                                
1                       0                                                 
Dimethicone, 1000 centistokes                                             
% W/W                   % Mortality                                       
15                      100                                               
13                      100                                               
11                      95                                                
9                       85                                                
7                       90                                                
5                       65                                                
3                       40                                                
1                       0                                                 
Dimethicone, 12,000 centistokes                                           
% W/W                   % Mortality                                       
15                      100                                               
13                      85                                                
11                      40                                                
9                       10                                                
7                       75                                                
5                       0                                                 
3                       0                                                 
1                       0                                                 
______________________________________
As can be seen from the foregoing, the viscosity range of 100-1000 centistokes for the dimethicones tested exhibit the highest pediculicidal activity below a 15% W/W concentration. The one phenyldimethicone derivative tested displays equivalent activity but at a much lower viscosity value.
As noted above, various end use formulations can be prepared. Some typical formulations are set forth below and the amounts recited are percentages by weight.
              EXAMPLES                                                    
______________________________________                                    
Gel                                                                       
Isopropanol                 25.0                                          
Dimethicone, 100 centistokes                                              
                            15.0                                          
Sorbitan monolaurate        7.5                                           
Carbomer 940                3.0                                           
Triethanolamine             4.0                                           
Water                       45.5                                          
Aerosol Spray                                                             
Ethanol                     70.0                                          
Phenyldimethicone, 22.5 centistokes                                       
                            15.0                                          
Isobutane                   15.0                                          
Powder                                                                    
Talc                        90.0                                          
Dimethicone, 900 centistokes                                              
                            10.0                                          
Quick breaking aerosol foam                                               
Mono and diglycerides from the glycerides of                              
edible fats                 8.0                                           
Isopropanol                 25.0                                          
Dimethicone, 350 centistokes                                              
                            15.0                                          
Glycerine                   3.0                                           
Water                       41.0                                          
Isobutane                   8.0                                           
Stick                                                                     
Sodium stearate             8.0                                           
Ethanol                     77.0                                          
Phenyldimethicone, 22.5 centistokes                                       
                            15.0                                          
Cream                                                                     
Beeswax                     10.0                                          
Dimethicone, 100 centistokes                                              
                            15.0                                          
Cetyl alcohol               3.0                                           
Mineral oil                 8.0                                           
Glycerylmonostearate        5.0                                           
Sorbitan monolaurate        4.0                                           
Isopropanol                 25.0                                          
Xanthan gum                 0.2                                           
Sodium borate, pentahydrate 0.75                                          
Water                       29.05                                         
______________________________________
Various changes and modifications can be made in the present invention without departing from the scope and the spirit thereof. The various embodiments which have been described above were set forth for illustration purposes only and were not intended to limit the invention. Unless otherwise specified, throughout this specification and claims, all temperatures have been in degrees Centigrade and all parts and percentages by weight.

Claims (7)

We claim:
1. A method of controlling ectoparasites or their ova which comprises applying to an animal or human in need of such control, an effective toxic amount of at least one linear siloxane polymer having repeating units R2 SiO in which each R is individually alkyl or aryl and having a viscosity of less than about 20,000 centistokes.
2. The method of claim 1 wherein said polymer has a viscosity of less than about 10,000 centistokes.
3. The method of claim 2 wherein said polymer has a viscosity of about 1,000 centistokes or less.
4. The method of claim 1 wherein said polymer is dimethicone or phenyldimethicone.
5. The method of claim 1 wherein said polymer is simethicone.
6. The method of claim 1 wherein said polymer is employed in combination with an inert pharmaceutically acceptable carrier.
7. The method of claim 6 wherein said carrier is aqueous.
US05/802,013 1977-05-31 1977-05-31 Siloxane toxicants Expired - Lifetime US4146619A (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
US05/802,013 US4146619A (en) 1977-05-31 1977-05-31 Siloxane toxicants
GB32135/77A GB1604853A (en) 1977-05-31 1977-10-18 Use of siloxanes as ectoparasiticides
PH21156A PH15528A (en) 1977-05-31 1978-05-18 Siloxane toxicants
AU36435/78A AU515942B2 (en) 1977-05-31 1978-05-24 Siloxane toxicants
CH574678A CH630238A5 (en) 1977-05-31 1978-05-26 POLYSILOXANE-BASED ECTOPARASITICIDES.
MX10098378U MX7145E (en) 1977-05-31 1978-05-29 AN IMPROVED PROCEDURE FOR PREPARING AN ECTOPARASITICIDE AND OVICID COMPOSITION BASED ON LINEAR SILOXANE POLYMERS
FR7816052A FR2392604A1 (en) 1977-05-31 1978-05-30 POLYSILOXANE INSECTICIDES
BE188157A BE867616A (en) 1977-05-31 1978-05-30 POLYSILOXANE INSECTICIDES
CA304,437A CA1108529A (en) 1977-05-31 1978-05-30 Siloxane toxicants
DE19782823595 DE2823595A1 (en) 1977-05-31 1978-05-30 MEANS FOR DISTRIBUTING ECTOPARASITES AND / OR KILLING THEIR EGGS
JP6446378A JPS545027A (en) 1977-05-31 1978-05-31 Siloxane poison

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/802,013 US4146619A (en) 1977-05-31 1977-05-31 Siloxane toxicants

Publications (1)

Publication Number Publication Date
US4146619A true US4146619A (en) 1979-03-27

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US05/802,013 Expired - Lifetime US4146619A (en) 1977-05-31 1977-05-31 Siloxane toxicants

Country Status (10)

Country Link
US (1) US4146619A (en)
JP (1) JPS545027A (en)
AU (1) AU515942B2 (en)
BE (1) BE867616A (en)
CA (1) CA1108529A (en)
CH (1) CH630238A5 (en)
DE (1) DE2823595A1 (en)
FR (1) FR2392604A1 (en)
GB (1) GB1604853A (en)
PH (1) PH15528A (en)

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0191543A1 (en) * 1985-01-15 1986-08-20 Ventec Laboratories, Inc. Silicone insect toxicants
US4654328A (en) * 1984-11-13 1987-03-31 Shin-Etsu Chemical Co., Ltd. Method for controlling sanitary and agricultural pests
US4656162A (en) * 1982-08-31 1987-04-07 Shin-Etsu Chemical Co., Ltd. Method for controlling sanitary and agricultural pests
US4668666A (en) * 1984-12-05 1987-05-26 Adams Veterinary Research Laboratories Long-acting pyrethrum/pyrethroid based pesticides with silicone stabilizers
US4983413A (en) * 1988-06-08 1991-01-08 Curtice-Burns, Inc. Low-calorie polysiloxane oil food products
US5626859A (en) * 1993-12-30 1997-05-06 Fitch; Joanne A. Ectoparasite control stick for domesticated animals
EP1207908A1 (en) * 1999-08-19 2002-05-29 David Holzer Method of treating body insect infestation
WO2002074088A1 (en) * 2001-03-16 2002-09-26 Durminster Limited Arthropodicidal compositions
US20030013683A1 (en) * 1999-08-19 2003-01-16 David Holzer Method of treating body insect infestation
US6663876B2 (en) 2002-04-29 2003-12-16 Piedmont Pharmaceuticals, Llc Methods and compositions for treating ectoparasite infestation
EP1663131A1 (en) * 2003-08-02 2006-06-07 LRC Products Limited Parasiticidal composition
US20070142330A1 (en) * 1999-09-16 2007-06-21 Jayne Ansell Method and composition for the control of arthropods
US20070212382A1 (en) * 2006-03-13 2007-09-13 Marianne Boskamp Composition for combating ectoparasites and their ova
US20100015064A1 (en) * 2007-01-16 2010-01-21 Oystershell N.V. Foamable composition for killing arthropods and uses thereof
GB2470208A (en) * 2009-05-14 2010-11-17 Thornton & Ross Ltd Treatment of head lice
BE1018708A3 (en) * 2009-04-01 2011-07-05 Lab Qualiphar METHOD FOR COMBATING INSECTS
US20110165094A1 (en) * 2008-09-22 2011-07-07 Bio.Lo.Ga S.R.L. Use of vitamin e or derivatives thereof for the control of arthropods
US20110183937A1 (en) * 2009-07-24 2011-07-28 Henning Ueck Agent for Combating Ectoparasites
WO2012069785A2 (en) 2010-11-25 2012-05-31 Excella-Tec Limited A composition and method for the control of arthropods

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5731925A (en) * 1980-08-01 1982-02-20 Nippon Ester Co Ltd Production of polyester
DE3029426A1 (en) * 1980-08-02 1982-03-11 Bayer Ag, 5090 Leverkusen AGAINST EFFECTIVE POUR-ON FORMULATIONS
JPS59225111A (en) * 1983-06-07 1984-12-18 Kao Corp Composition for cleaning and wiping skin around anus
GB8402637D0 (en) * 1984-02-01 1984-03-07 Beecham Group Plc Cosmetic
GB9921858D0 (en) * 1999-09-16 1999-11-17 Ansell Jane Composition and method for the eradication of head lice
JP4890798B2 (en) * 2004-06-24 2012-03-07 エステー株式会社 Insect repellent, insect repellent using the same, and method
JP5373874B2 (en) * 2004-06-24 2013-12-18 エステー株式会社 Insect repellent, insect repellent using the same, and method
US20060140995A1 (en) * 2004-12-23 2006-06-29 Precopio Michael J Methods for treating ectoparasite infections on the mammalian body
ES2749602T3 (en) 2014-07-30 2020-03-23 Icb Pharma Spolka Jawna Siloxane-free liquid dispersion composition comprising isopropyl myristate and isohexadecane to combat ectoparasites
JP2019081752A (en) * 2017-10-30 2019-05-30 アース製薬株式会社 Method of inhibiting colonization by blood-sucking pests and colonization inhibitor against blood-sucking pests
EP3524056B1 (en) 2018-02-09 2021-02-24 Beaphar B.V. Compositions for use in the treatment of lice and/or mites infestations on a horse

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2681878A (en) * 1951-09-04 1954-06-22 Dow Corning Insect repellent compositions
CA503996A (en) * 1954-06-29 The Kendall Company Pharmaceutical composition for use in the treatment of keratin
US2727846A (en) * 1951-08-22 1955-12-20 Silicote Corp Siloxane-containing dressing
US3470292A (en) * 1965-06-01 1969-09-30 Colgate Palmolive Co Film-forming composition containing a phosphatide and a siloxane
CA829873A (en) * 1969-12-16 George M. Grass, Jr. Powdered silicone products and processes
US3567820A (en) * 1969-04-09 1971-03-02 George S Sperti Compositions and treatment for the alleviation of diaper rash
US3880996A (en) * 1974-03-11 1975-04-29 Arthur I Fisher Topical analgesic preparation and method of using
US3953591A (en) * 1974-04-29 1976-04-27 The Procter & Gamble Company Fatty acid, polysiloxane and water-soluble polymer containing skin conditioning emulsion

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1061345A (en) * 1951-09-04 1954-04-12 Dow Corning Improvement of compositions intended to repel insects
FR1089762A (en) * 1952-12-20 1955-03-22 Siegel & Co Process for increasing the effectiveness of parasiticidal products
FR1131217A (en) * 1955-09-09 1957-02-19 Rech S Tech Soc Et Improvements made to insecticides, fungicides, etc.
BE567352A (en) * 1957-05-06
US2988473A (en) * 1957-07-16 1961-06-13 Gulf Research Development Co Petroleum hydrocarbon insecticidal composition containing organosilicon oxide condensation product
US3159536A (en) * 1960-04-22 1964-12-01 Monsanto Co Hydrophobic siliceous insecticidal compositions
GB1133201A (en) * 1965-02-26 1968-11-13 Midland Silicones Ltd Organosilicon compositions
AU468732B2 (en) * 1972-10-23 1976-01-22 Merck Sharp & Dohme (Australia) Pty. Limited Improved carrier compositions
CA1010782A (en) * 1973-02-20 1977-05-24 Charles A. Roth Articles exhibiting antimicrobial properties
DE2705228C2 (en) * 1977-02-08 1986-04-03 Dr. Werner Freyberg Chemische Fabrik Delitia Nachf., 6941 Laudenbach Hydrophobic, phosphine-evolving pesticide and process for its manufacture
JPS602284B2 (en) * 1977-02-26 1985-01-21 大日本除虫菊株式会社 How to maintain the effectiveness of volatile insecticides

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA503996A (en) * 1954-06-29 The Kendall Company Pharmaceutical composition for use in the treatment of keratin
CA829873A (en) * 1969-12-16 George M. Grass, Jr. Powdered silicone products and processes
US2727846A (en) * 1951-08-22 1955-12-20 Silicote Corp Siloxane-containing dressing
US2681878A (en) * 1951-09-04 1954-06-22 Dow Corning Insect repellent compositions
US3470292A (en) * 1965-06-01 1969-09-30 Colgate Palmolive Co Film-forming composition containing a phosphatide and a siloxane
US3567820A (en) * 1969-04-09 1971-03-02 George S Sperti Compositions and treatment for the alleviation of diaper rash
US3880996A (en) * 1974-03-11 1975-04-29 Arthur I Fisher Topical analgesic preparation and method of using
US3953591A (en) * 1974-04-29 1976-04-27 The Procter & Gamble Company Fatty acid, polysiloxane and water-soluble polymer containing skin conditioning emulsion

Cited By (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4656162A (en) * 1982-08-31 1987-04-07 Shin-Etsu Chemical Co., Ltd. Method for controlling sanitary and agricultural pests
US4654328A (en) * 1984-11-13 1987-03-31 Shin-Etsu Chemical Co., Ltd. Method for controlling sanitary and agricultural pests
US4668666A (en) * 1984-12-05 1987-05-26 Adams Veterinary Research Laboratories Long-acting pyrethrum/pyrethroid based pesticides with silicone stabilizers
EP0191543A1 (en) * 1985-01-15 1986-08-20 Ventec Laboratories, Inc. Silicone insect toxicants
US4983413A (en) * 1988-06-08 1991-01-08 Curtice-Burns, Inc. Low-calorie polysiloxane oil food products
US5626859A (en) * 1993-12-30 1997-05-06 Fitch; Joanne A. Ectoparasite control stick for domesticated animals
EP1207908A1 (en) * 1999-08-19 2002-05-29 David Holzer Method of treating body insect infestation
EP1207908A4 (en) * 1999-08-19 2002-09-11 David Holzer Method of treating body insect infestation
US20030013683A1 (en) * 1999-08-19 2003-01-16 David Holzer Method of treating body insect infestation
US6683065B1 (en) * 1999-08-19 2004-01-27 Host Pharmaceuticals Llc Method of treating body insect infestation
US20040242541A1 (en) * 1999-08-19 2004-12-02 David Holzer Method of treating body insect infestation
US7829551B2 (en) 1999-09-16 2010-11-09 Durminster Limited Method and composition for the control of arthropods
US20070142330A1 (en) * 1999-09-16 2007-06-21 Jayne Ansell Method and composition for the control of arthropods
US20050101566A1 (en) * 2001-03-16 2005-05-12 Burgess Ian F. Arthropodicidal compositions
WO2002074088A1 (en) * 2001-03-16 2002-09-26 Durminster Limited Arthropodicidal compositions
US8178116B2 (en) 2002-04-29 2012-05-15 Piedmont Pharmaceuticals, Llc Methods and compositions for treating ectoparasite infestation
US6663876B2 (en) 2002-04-29 2003-12-16 Piedmont Pharmaceuticals, Llc Methods and compositions for treating ectoparasite infestation
US8815270B2 (en) 2002-04-29 2014-08-26 Piedmont Pharmaceuticals, Llc Methods and compositions for treating ectoparasite infestation
US20040086540A1 (en) * 2002-04-29 2004-05-06 Piedmont Pharmaceuticals, Llc Methods and compositions for treating ectoparasite infestation
EP1663131A1 (en) * 2003-08-02 2006-06-07 LRC Products Limited Parasiticidal composition
US20060275334A1 (en) * 2003-08-02 2006-12-07 Jasmina Dokic-Gallagher Parasiticidal composition
US20070212382A1 (en) * 2006-03-13 2007-09-13 Marianne Boskamp Composition for combating ectoparasites and their ova
US20100015064A1 (en) * 2007-01-16 2010-01-21 Oystershell N.V. Foamable composition for killing arthropods and uses thereof
US20110165094A1 (en) * 2008-09-22 2011-07-07 Bio.Lo.Ga S.R.L. Use of vitamin e or derivatives thereof for the control of arthropods
BE1018708A3 (en) * 2009-04-01 2011-07-05 Lab Qualiphar METHOD FOR COMBATING INSECTS
DE112010001992T5 (en) 2009-05-14 2013-08-22 Thornton & Ross Ltd. Method and composition for controlling ectoparasites
GB2470208B (en) * 2009-05-14 2014-01-29 Thornton & Ross Ltd A method and composition for the control of ectoparasites
GB2470208A (en) * 2009-05-14 2010-11-17 Thornton & Ross Ltd Treatment of head lice
DE112010001992B4 (en) 2009-05-14 2022-10-13 Thornton & Ross Ltd. Ectoparasiticidal compositions and their use for controlling ectoparasites
US20110183937A1 (en) * 2009-07-24 2011-07-28 Henning Ueck Agent for Combating Ectoparasites
WO2012069785A2 (en) 2010-11-25 2012-05-31 Excella-Tec Limited A composition and method for the control of arthropods

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BE867616A (en) 1978-11-30
DE2823595A1 (en) 1978-12-14
AU515942B2 (en) 1981-05-07
FR2392604B1 (en) 1983-12-09
CA1108529A (en) 1981-09-08
PH15528A (en) 1983-02-09
JPS545027A (en) 1979-01-16
AU3643578A (en) 1979-11-29
FR2392604A1 (en) 1978-12-29
CH630238A5 (en) 1982-06-15
GB1604853A (en) 1981-12-16
JPS6343371B2 (en) 1988-08-30

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