|Número de publicación||US4416274 A|
|Tipo de publicación||Concesión|
|Número de solicitud||US 06/236,753|
|Fecha de publicación||22 Nov 1983|
|Fecha de presentación||23 Feb 1981|
|Fecha de prioridad||23 Feb 1981|
|También publicado como||CA1181490A, CA1181490A1, DE3271718D1, EP0058920A1, EP0058920B1|
|Número de publicación||06236753, 236753, US 4416274 A, US 4416274A, US-A-4416274, US4416274 A, US4416274A|
|Inventores||Stephen C. Jacobsen, Richard D. Luntz|
|Cesionario original||Motion Control, Inc.|
|Exportar cita||BiBTeX, EndNote, RefMan|
|Citas de patentes (7), Citada por (109), Clasificaciones (6), Eventos legales (5)|
|Enlaces externos: USPTO, Cesión de USPTO, Espacenet|
This invention relates to an iontophoretic bioelectrode method and apparatus and more particularly to such a method and apparatus in which migration of ions from the apparatus to a person's skin or skin barrier is inhibited in certain directions.
Iontophoresis is a technique of delivering ions into a person's skin or tissue by placing a solution or other medium containing the ions in contact with the skin, and applying electric current to the medium. The solution or medium containing the ions is typically carried by a first bioelectrode pouch or receptacle. Ions are caused to migrate from the ion carrying medium through the skin or tissue by the application of the electric current to the medium, and by placement against the skin of a second bioelectrode within some proximity of the first bioelectrode and the application of current of opposite polarity to the second bioelectrode. This technique has been discussed in a number of prior art patents including U.S. Pat. No. 4,141,359 and 4,166,457. Examples of bioelectrodes which are generally useful for making electrical contact with the skin are described in U.S. Pat. Nos. 3,862,633, 3,945,384 and 3,973,557.
There have been several bioelectrode proposals for carrying the ion solution or medium and placing it in proximity with the skin including provision of a receptacle with a wetable barrier on one side thereof. The wetable barrier or wall is covered until time of use and then uncovered for placement against the skin. Then, upon application of the electrical current, the ions migrate through the wall into the skin.
Another proposed arrangement involves the use of a receptacle having a microporous membrane on one side thereof which may be placed in contact with a person's skin. The membrane is selected so that it will not leak prior to use, but will allow migration of ions therethrough to the skin upon application of an electric current to the ion-carrying solution. With this arrangement, less care need be given to storage, transport and use of the receptacle since the ion containing fluid will not leak as it is used.
One of the principal problems with the prior art devices has been the problem of the bioelectrode producing burns at the site of application of medications. If the current to the bioelectrode is too high, the resistance of the skin or tissue may result in burns or other tissue damage. Further, once the skin or tissue is burned, the resistance at the site of the burn decreases allowing for an increase in current flow and thus ion migration at that site and this compounds the danger of serious burns to the skin or tissue. If a blemish or cut exists somewhere at the location of contact of the bioelectrode with the skin or tissue, then the ions tend to migrate toward and concentrate at the blemish thereby increasing the danger of a burn at that site.
One approach to reducing the likelihood of burns to the skin or tissue is to simply reduce the amount of current applied to the bioelectrode. This, however, increases the treatment time for the patient since lower current flow requires longer periods of application to reach the same degree of ion penetration. Of course, it would be desirable to both minimize the treatment time and minimize the likelihood of burns to the patient from the treatment.
It is an object of the invention to provide a new and improved bioelectrode for use in the iontophoretic delivery of ions into the skin or tissue of a person.
It is another object of the invention to provide such as bioelectrode in which the likelihood of burns to the skin or tissue is reduced.
It is a further object of the invention to provide such a bioelectrode wherein the lateral mobility of the ions in the electrode is inhibited.
It is an additional object of the invention to provide a bioelectrode for delivering ions into the skin or tissue of a person uniformly over a certain skin or tissue surface area regardless of local variations in skin impedance such as that caused by previous tissue damage.
It is also an object of the invention, in accordance with one aspect thereof to provide a bioelectrode adapted to minimize the chance of chemically induced iontophoretic ph burns.
The above and other objects of the invention are realized in a bioelectrode structure which includes a holder for holding ions to be delivered, one side of which is for placement against the person's skin or tissue. The holder is adapted to inhibit movement of ions in a direction generally parallel to the surface of the skin or tissue while allowing movement toward the side which is placed against the skin or tissue. Also included is an electrically conductive sheet of material attached to and covering a substantial portion of the other side of the holder, and an electrical conductor coupled to the sheet of material for connection to an electrical source.
Electrical current is supplied by the conductor to the sheet of material to cause the ions contained in the holder to migrate towards the side of the holder in contact with the skin. Since lateral movement of ions is inhibited by the holder (due to the longer current path lengths), the likelihood of burning is decreased since movement of ions to concentrate at one place is inhibited.
The holder can be adapted to inhibit the lateral movement of ions either by including structure within the holder to physically guide the ions or by proper selection and dimensioning of the ion holding material to enhance migration in one direction while inhibiting migration in another direction. An example of the latter is gel material preloaded with ions. By Incorporation of an appropriate phosphate buffer in the gel material, chemically induced iontophoretic ph burns can better be avoided.
The above and other objects, features and advantages of the invention will become apparent from a consideration of the following detailed description presented in connection with the accompanying drawings in which:
FIG. 1 is a perspective view of a bioelectrode made in accordance with the principles of the present invention;
FIG. 2 is a side, cross-sectional view of the bioelectrode of FIG. 1;
FIG. 3 is a perspective view of another embodiment of the invention;
FIG. 4 is a side, cross-sectional view of the bioelectrode of FIG. 3;
FIG. 5 is a top, cross-sectional view of one embodiment of the interior structure of the bioelectrode of FIG. 3;
FIG. 6 is a top, cross-sectional view of another embodiment of the interior structure of the bioelectrode of FIG. 3; and
FIG. 7 is a top, cross-sectional view of still another embodiment of the interior structure of the bioelectrode of FIG. 3.
Referring to the drawings there are shown several embodiments of an iontophoresis device made in accordance with the present invention. FIGS. 1 and 2 show a bioelectrode 2 composed of an upper cover 4 which may be made of plastic, treated paper, or other suitable covering material. Mounted in the cover 4 is the male part 8 of a conventional metallic snap used on clothing and the like. The snap 8 includes an upwardly projecting nipple 8a which protrudes through the cover 4 so that contact may be had with the corresponding female part of the snap or other suitable conductor. The nipple 8a is joined to a base portion 8b which is disposed on the underneath side of the cover 4.
Affixed to the underneath side of the cover 4 in contact with the base portion 8b of the snap 8 is a piece of flexible foil 12 made of aluminum or other electrically conductive material. The foil 12 is in electrical contact with the snap 8 so that any electrical current applied to the snap 8 will flow to the foil 12. Affixed to the underneath side of the foil 12 is a sheet of iontophoresis gel 16 such as karaya gum, other polysacharide gels, or similar hydrophillic aqueous gels capable of carrying ions. Specific examples of such gels include polyvinyl alcohol, polymethyl pyrollidine, methyl cellulose, polyacrylamide, polyhemas, and polyhema derivatives, etc. The perimeter of the gel 16 is substantially coterminous with the foil 12 as shown in the drawings. The gel selected should have nonirritating properties to avoid irritating the person's skin or tissue, suitable viscosity and surfactant properties to obtain good electrical contact with the skin or tissue, and the ability to act as a carrier medium for the ions. The lower surface of the gel 16 is for placement in contact with a person's skin or tissue for the iontophoretic treatment.
In order to minimize the chance of chemically induced iontophoretic ph burns in the surface tissues and the underlying tissues in the area of placement of the device, a phosphate buffer, such as mono-basic and/or di-basic sodium phosphate, is included in the gel material 16. Advantageously, a ph of about six will be provided in the gel.
The gel 16 is dimensioned so that ion migration is enhanced in a direction normal to the person's skin or tissue, and generally inhibited in a direction parallel to the person's skin. It has been found that a thickness-to-width ratio of about 0.1 facilitates such control of the migration of ions. These controls on ion migration are desirable to provide a more uniform transfer of ions from the entire bottom surface area of the gel into the person's skin. That is, ion migration is stimulated to take place from the gel 16 over the shortest path to the skin, and migration laterally of ions to points of high current intensity for delivery into the skin is avoided.
A bottom cover 20 is placed in contact with the lower surface of the gel material 16 until time of use of the bioelectrode to keep the gel free from contamination. The upper cover 4 and lower cover 20 thus completely enclose the gel material 16 until the bioelectrode is to be used. Then, the bottom cover 20 is simply peeled from the gel material and the gel material is placed in contact with the patient's skin or tissue. The cover 20 may be made of any suitable material such as plastic, treated paper, etc., which will maintain the gel material 16 free from contamination. Ears 20a and 20b are formed in the cover 20 to extend outwardly beyond the perimeter of the upper cover 4 to facilitate peeling the bottom cover from the gel material 16.
In use, the bioelectrode of FIGS. 1 and 2 is prepared with the ionic medicament carried in the gel material 16. The bioelectrode would then be delivered in a form generally as shown in the drawings and used as needed. In such use, as explained in the aforecited patents and in copending patent application, Ser. No. 963,029, the bioelectrode of FIG. 2 would be placed against a person's skin with the gel material 16 in contact with the skin. Another electrode would be placed against the skin at a location spaced from the first electrode. Appropriate electric potentials would then be applied to electrodes to create a potential gradient between the electrode carrying the medicament and the skin.
FIGS. 3 and 4 show respectively a perspective view of another embodiment of the present invention and a side, cross-sectional view thereof. In this embodment, a receptacle 28 for holding an ionic solution is formed of an upper wall 30 whose edges curve downwardly to join a bottom wall 34 (FIG. 4). The upper wall 30 is constructed of a flexible, deformable material such as polyurethane suitable for holding an ionic solution to be delivered through the skin or tissue of a person. The bottom wall 34 is composed of a porous, microporous, permeable or semipermeable membrane material such as microporous polycarbonate, microporous polytetrafluoroethylene or polyacrylonitrile, through which the ions in the solution can pass to the person's skin. This construction, as discussed thus far is disclosed in copending application, Ser. No. 963,029.
Disposed in the upper wall 30 of the bioelectrode 28 is a male part of a metallic snap 38 similar to that described for FIGS. 1 and 2. The nipple of the snap 38 projects from the upper surface of the wall 30 to make electrical contact with a corresponding female part of a snap (or other suitable conductor). The snap 38 includes a base portion which is positioned at the bottom surface of the upper wall 30 in contact with a conductive sheet of material 42 which is affixed to the bottom surface of the wall 30. Temporarily affixed to the bottom surface of the bottom wall 34 is a sanitary cover 46 which, when the bioelectrode is to be used, is simply peeled off. While in place, the cover 46 maintains the bottom wall 34 free from contamination.
Disposed in the cavity 48 formed by the upper wall 30 and bottom wall 34 are a plurality of partition walls 50 which extend from the foil 42 to the bottom wall 34. The partition walls 50 may be arranged in a variety of shapes to generally prevent migration of ions laterally in the bioelectrode receptacle. Three examples of the formation of partition walls in the bioelectrode are shown in FIGS. 5, 6 and 7. In FIG. 5 partition walls 52 are shown in a grid pattern and define a plurality of separate, cube-shaped compartments 54. The material of the walls 52 is selected so as to prevent passage therethrough of the ions in the solution. Such material could be nonporous polyurethane. In FIG. 6, partition walls 56 are formed concentrically to define a plurality of annular compartments 58. The partition wall configuration of FIG. 5 prevents migration of ions in almost every lateral direction. The partition walls 56 in FIG. 6 prevent radial migration of ions but, of course, would not prevent a circumferential migration in each of the compartments. Other partition wall shapes, such as the spiral configuration of walls 60 shown in FIG. 7, could be devised to generally prevent lateral migration in the receptacle of the bioelectrode of FIGS. 3 and 4.
With the structure shown in FIGS. 3 through 7, ions are generally prevented from migrating in a direction parallel with the surface of the skin or tissue into which the ions are to be applied because of the positioning by the partition walls. Rather, the ions are constrained to migrate through the bottom wall 34 generally uniformly over the surface area of contact by the skin with the bottom wall. Also, with the configurations of FIGS. 3-7, a given compartment in a device is allowed to deplete itself of ions and force conduction through an adjacent compartment. Thus, when a given compartment is depleted of ions over a skin site of reduced impedance (i.e. burn, scratch, or other tissue damage) the movement to an adjacent site of conduction thus reduces the likelihood of a serious burn taking place or minimizes such burning or other tissue damage in the area of reduced tissue impedance. Indeed the depletion of ions from one region and the recruitment of an adjacent conduction site occurs throughout the iontophoretic treatment process in a continuous manner so that the total charge delivered to the skin is uniformly distributed to each area of the skin adjacent to the electrode surface. Such uniform current distribution and continuous recruitment of conduction sites operates to minimize iontophoretically induced burns.
In the manner described, iontophoretic bioelectrodes are provided wherein ion mobility is primarily limited to a direction normal to the surface of the skin or tissue into which the ions are to be applied. By so limiting the mobility of the ions, the likelihood of a concentration and delivery of ions at one or more points on the skin or tissue is avoided, and thus the likelihood of burns is reduced.
It should be understood that the above-defined embodiments are only illustrative of the application of the principles of the present invention and that numerous other alternative embodiments could be described without departing from the spirit and scope of the invention. For example, the partition walls 50 of the embodiment of FIGS. 3 and 4 could take a variety of shapes to prevent the lateral migration of ions. Also, various gel materials might be used in the FIGS. 1 and 2 embodiment so long as appropriate dimensions were selected for such material to stimulate the desired migration direction and inhibit the undesirable lateral migration. The appended claims are intended to cover all described embodiments and alternative embodiments which the present invention might have.
|Patente citada||Fecha de presentación||Fecha de publicación||Solicitante||Título|
|US3567657 *||29 May 1968||2 Mar 1971||Lichtenstein Joseph||Electrically conductive skin conditioning system|
|US3848600 *||30 Ene 1973||21 Jun 1988||Título no disponible|
|US4033334 *||3 Dic 1975||5 Jul 1977||Nasa||Snap-in compressible biomedical electrode|
|US4164226 *||13 Jun 1977||14 Ago 1979||Robert Tapper||Iontophoretic burn-protection electrode structure|
|US4250878 *||22 Nov 1978||17 Feb 1981||Motion Control, Inc.||Non-invasive chemical species delivery apparatus and method|
|DE2440836A1 *||26 Ago 1974||11 Mar 1976||Heinz Doering||Distributing plate for electrodes on skin surface - providing contact between electrode plate and skin surface is perforated plastics disc|
|DE2727396A1 *||18 Jun 1977||21 Dic 1978||Beiersdorf Ag||Elektrisch leitendes, viskoelastisches gel|
|Patente citante||Fecha de presentación||Fecha de publicación||Solicitante||Título|
|US4465074 *||20 Abr 1982||14 Ago 1984||Gilbert Buchalter||Method of applying an electrode to the skin of a patient|
|US4474570 *||8 Jul 1982||2 Oct 1984||Kabushikikaisya Advance Kaihatsu Kenkyujo||Iontophoresis device|
|US4477971 *||27 Sep 1983||23 Oct 1984||Motion Control, Inc.||Iontophoretic electrode structure|
|US4702732 *||21 Nov 1986||27 Oct 1987||Trustees Of Boston University||Electrodes, electrode assemblies, methods, and systems for tissue stimulation and transdermal delivery of pharmacologically active ligands|
|US4708716 *||16 Sep 1985||24 Nov 1987||Drug Delivery Systems Inc.||Transdermal drug applicator|
|US4722726 *||12 Feb 1986||2 Feb 1988||Key Pharmaceuticals, Inc.||Method and apparatus for iontophoretic drug delivery|
|US4731049 *||30 Ene 1987||15 Mar 1988||Ionics, Incorporated||Cell for electrically controlled transdermal drug delivery|
|US4731926 *||10 Dic 1985||22 Mar 1988||Drug Delivery Systems Inc.||Method of manufacturing disposable and/or replenishable transdermal drug applicators|
|US4734090 *||18 Jul 1986||29 Mar 1988||Drug Delivery Systems Inc.||Electrical transdermal drug applicator|
|US4752285 *||19 Mar 1986||21 Jun 1988||The University Of Utah Research Foundation||Methods and apparatus for iontophoresis application of medicaments|
|US4786277 *||24 Jul 1987||22 Nov 1988||Trustees Of Boston University||Electrodes, electrode assemblies, methods, and systems for tissue stimulation|
|US4820263 *||7 Nov 1987||11 Abr 1989||Medtronic, Inc.||Apparatus and method for iontophoretic drug delivery|
|US4886489 *||19 Jun 1987||12 Dic 1989||Jacobsen Stephen C||Flow-through methods and apparatus for iontophoresis application of medicaments at a controlled pH|
|US4915685 *||19 Jun 1987||10 Abr 1990||Petelenz Tomasz J||Methods and apparatus for iontophoresis application of medicaments at a controlled ph through ion exchange|
|US4973303 *||5 Sep 1989||27 Nov 1990||Empi, Inc.||pH buffered electrode for medical iontophoresis|
|US4994023 *||8 Ago 1989||19 Feb 1991||Wellinghoff Stephen T||Electrochemical drug release and article|
|US5002527 *||6 Dic 1988||26 Mar 1991||Inventor's Funding Corp. Ltd.||Transdermal drug delivery applicators|
|US5032109 *||1 Nov 1989||16 Jul 1991||Drug Delivery Systems Inc.||Electrolytic transdermal delivery of polypeptides|
|US5057072 *||21 Nov 1990||15 Oct 1991||Medtronic, Inc.||Iontophoresis electrode|
|US5084008 *||22 Dic 1989||28 Ene 1992||Medtronic, Inc.||Iontophoresis electrode|
|US5087240 *||30 Oct 1989||11 Feb 1992||Drug Delivery Systems Inc.||Transdermal drug patch with conductive fibers|
|US5087241 *||24 Jul 1990||11 Feb 1992||Empi, Inc.||Iontophoresis electrode with reservoir and injection site|
|US5087242 *||21 Jul 1989||11 Feb 1992||Iomed, Inc.||Hydratable bioelectrode|
|US5125894 *||30 Mar 1990||30 Jun 1992||Alza Corporation||Method and apparatus for controlled environment electrotransport|
|US5135477 *||10 Feb 1988||4 Ago 1992||Medtronic, Inc.||Iontophoretic drug delivery|
|US5135479 *||6 Jun 1991||4 Ago 1992||Drug Delivery Systems, Inc.||Programmable control and mounting system for transdermal drug applicator|
|US5160316 *||10 Sep 1990||3 Nov 1992||Henley Julian L||Iontophoretic drug delivery apparatus|
|US5163899 *||12 Dic 1989||17 Nov 1992||Drug Delivery Systems Inc.||Transdermal drug delivery system|
|US5279543 *||30 Abr 1992||18 Ene 1994||The Regents Of The University Of California||Device for iontophoretic non-invasive sampling or delivery of substances|
|US5282785 *||5 Oct 1992||1 Feb 1994||Cortrak Medical, Inc.||Drug delivery apparatus and method|
|US5284471 *||28 Jun 1990||8 Feb 1994||Becton, Dickinson And Company||Electrode and method used for iontophoresis|
|US5286254 *||28 Ago 1992||15 Feb 1994||Cortrak Medical, Inc.||Drug delivery apparatus and method|
|US5310403 *||18 May 1992||10 May 1994||Becton, Dickinson And Company||Iontophoretic drug delivery device and circuit therefor|
|US5310404 *||1 Jun 1992||10 May 1994||Alza Corporation||Iontophoretic delivery device and method of hydrating same|
|US5328455 *||29 Mar 1993||12 Jul 1994||Iomed, Inc.||Rehydratable product and method of preparation thereof|
|US5331979 *||27 Jul 1992||26 Jul 1994||Henley Julian L||Iontophoretic cigarette substitute|
|US5362307 *||4 Oct 1991||8 Nov 1994||The Regents Of The University Of California||Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance|
|US5374241 *||7 Abr 1993||20 Dic 1994||Iomed, Inc.||Electrodes for iontophoresis|
|US5395310 *||21 Dic 1990||7 Mar 1995||Alza Corporation||Iontophoresis electrode|
|US5415628 *||2 Ago 1993||16 May 1995||Alza Corporation||Iontophorett drug delivery|
|US5431625 *||1 Dic 1992||11 Jul 1995||Empi, Inc.||Iontophoresis electronic device having a ramped output current|
|US5443442 *||22 Dic 1993||22 Ago 1995||Alza Corporation||Method and apparatus for controlled environment electrotransport|
|US5458568 *||17 Sep 1993||17 Oct 1995||Cortrak Medical, Inc.||Porous balloon for selective dilatation and drug delivery|
|US5498238 *||27 Ago 1993||12 Mar 1996||Cortrak Medical, Inc.||Simultaneous angioplasty and phoretic drug delivery|
|US5533971 *||3 Sep 1993||9 Jul 1996||Alza Corporation||Reduction of skin irritation during electrotransport|
|US5533972 *||30 Sep 1993||9 Jul 1996||Alza Corporation||Iontophoretic delivery device and method of hydrating same|
|US5558632 *||3 Nov 1994||24 Sep 1996||Iomed, Inc.||Electrodes for iontophoresis|
|US5573503 *||30 Abr 1993||12 Nov 1996||Alza Corporation||Iontophoretic drug delivery|
|US5582587 *||9 May 1994||10 Dic 1996||Alza Corporation||Iontophoretic delivery device and method of hydrating same|
|US5591123 *||30 Ene 1995||7 Ene 1997||Drug Delivery Systems Inc.||Programmable control mounting system for transdermal drug applicator|
|US5591124 *||26 May 1995||7 Ene 1997||Alza Corporation||Method and apparatus for controlled environment electrotransport|
|US5622530 *||26 May 1995||22 Abr 1997||Alza Corporation||Method and apparatus for controlled environment electrotransport|
|US5628730 *||18 Jul 1994||13 May 1997||Cortrak Medical, Inc.||Phoretic balloon catheter with hydrogel coating|
|US5678545 *||4 May 1995||21 Oct 1997||Stratbucker; Robert A.||Anisotropic adhesive multiple electrode system, and method of use|
|US5730714 *||26 Sep 1994||24 Mar 1998||The Regents Of The University Of California||Method for the iontophoretic non-invasive determination of the in vivo concentration level of glucose|
|US5788666 *||15 Jun 1995||4 Ago 1998||Empi, Inc.||Iontophoresis electrode|
|US5807306 *||16 Ago 1994||15 Sep 1998||Cortrak Medical, Inc.||Polymer matrix drug delivery apparatus|
|US5840056 *||15 Jun 1995||24 Nov 1998||Empi, Inc.||Iontophoresis electrode|
|US5865786 *||7 Jun 1995||2 Feb 1999||Drug Delivery Systems, Inc.||Programmable control and mounting system for transdermal drug applicator|
|US5961482 *||19 Mar 1996||5 Oct 1999||Rutgers, The State University Of New Jersey||Iontotherapeutic device and process and iontotherapeutic unit dose|
|US5989409 *||11 Sep 1995||23 Nov 1999||Cygnus, Inc.||Method for glucose sensing|
|US6004309 *||18 Abr 1997||21 Dic 1999||Alza Corporation||Method and apparatus for controlled environment electrotransport|
|US6018679 *||29 Ene 1997||25 Ene 2000||Novartis Finance Corp.||Iontophoretic transdermal delivery and control of adverse side-effects|
|US6163720 *||3 Dic 1998||19 Dic 2000||Alza Corporation||Layered rate controlling membranes for use in an electrotransport device|
|US6231516||23 Feb 1998||15 May 2001||Vacusense, Inc.||Endoluminal implant with therapeutic and diagnostic capability|
|US6284126||28 Ago 2000||4 Sep 2001||Cygnus, Inc.||Electrode with improved signal to noise ratio|
|US6289241||10 Jun 1998||11 Sep 2001||Alza Corporation||Method and apparatus for controlled environment electrotransport|
|US6319240||25 May 1999||20 Nov 2001||Iomed, Inc.||Methods and apparatus for ocular iontophoresis|
|US6327487 *||16 Ago 1999||4 Dic 2001||Robert A. Stratbucker||Bioelectric interface|
|US6355025||7 Jun 1995||12 Mar 2002||Alza Corporation||Adjustable electrotransport drug delivery using a fixed output controller|
|US6539251||3 Ago 2001||25 Mar 2003||Iomed, Inc.||Ocular iontophoretic apparatus|
|US6542765||10 Mar 1998||1 Abr 2003||The Regent Of The University Of California||Method for the iontophoretic non-invasive determination of the in vivo concentration level of an inorganic or organic substance|
|US6629968||30 Jun 2000||7 Oct 2003||Vyteris, Inc.||Shelf storage stable iontophoresis reservoir-electrode and iontophoretic system incorporating the reservoir-electrode|
|US6714815||13 Ene 2003||30 Mar 2004||The Regents Of The University Of California||Method for the iontophoretic non-invasive determination of the in vivo concentration level of an inorganic or organic substance|
|US6735470||18 Sep 2002||11 May 2004||Biophoretic Therapeutic Systems, Llc||Electrokinetic delivery of medicaments|
|US6792306||8 Abr 2002||14 Sep 2004||Biophoretic Therapeutic Systems, Llc||Finger-mounted electrokinetic delivery system for self-administration of medicaments and methods therefor|
|US6895271||26 Ago 2003||17 May 2005||Biophoretic Therapeutic Systems, Llc||Iontophoretic drug delivery electrodes and method|
|US6989275||22 Mar 2002||24 Ene 2006||Carnegie Mellon University||Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods|
|US7008798||22 Mar 2002||7 Mar 2006||Carnegie Mellon University||Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods|
|US7016724||1 Dic 2003||21 Mar 2006||Transport Pharmaceuticals, Inc.||Electrokinetic delivery system for self-administration of medicaments and methods therefor|
|US7069073||24 Mar 2004||27 Jun 2006||Biophoretic Therapeutic Systems, Llc||Electrokinetic delivery of medicaments|
|US7127285||7 Feb 2003||24 Oct 2006||Transport Pharmaceuticals Inc.||Systems and methods for electrokinetic delivery of a substance|
|US7162291 *||1 Mar 2000||9 Ene 2007||Mirabel Medical Systems Ltd.||Uniform, disposable, interface for multi-element probe|
|US7252655||3 Ago 2001||7 Ago 2007||Iomed, Inc.||Ocular iontophoretic apparatus handle|
|US7427265||24 Oct 2000||23 Sep 2008||Cardiometrix, Inc.||Endoluminal implant with therapeutic and diagnostic capability|
|US8197844||8 Jun 2007||12 Jun 2012||Activatek, Inc.||Active electrode for transdermal medicament administration|
|US8328788||11 May 2011||11 Dic 2012||Nitric Biotherapeutics, Inc.||Methods and systems for electrokinetic delivery of a substance|
|US8352024||13 Mar 2006||8 Ene 2013||Nitric Biotherapeutics, Inc.||Electrokinetic delivery system for self-administration of medicaments and methods therefor|
|US8788031||25 Oct 2006||22 Jul 2014||Encore Medical Asset Corporation||Method and device for the iontophoretic delivery of a drug|
|US8862223||18 Ene 2008||14 Oct 2014||Activatek, Inc.||Active transdermal medicament patch and circuit board for same|
|US9084879 *||25 Oct 2006||21 Jul 2015||Encore Medical Asset Corporation||Method and device for the iontophoretic delivery of a drug|
|US20020022794 *||3 Ago 2001||21 Feb 2002||Beck Jon E.||Ocular iontophoretic apparatus handle|
|US20050169976 *||28 Mar 2003||4 Ago 2005||Kenji Mori||Insulin administration apparatus|
|US20070100275 *||25 Oct 2006||3 May 2007||Iomed, Inc.||Method and device for the iontophoretic delivery of a drug|
|US20070100317 *||25 Oct 2006||3 May 2007||Iomed, Inc.||Method and device for the iontophoretic delivery of a drug|
|US20080312579 *||16 Jun 2008||18 Dic 2008||Transport Pharmaceuticals, Inc.||Method and system for mitigating current concentration in electrokinetic drug delivery|
|USRE36626 *||20 Jul 1998||28 Mar 2000||The Aps Organization, Llp||Iontophoretic drug delivery apparatus|
|USRE38681 *||2 Dic 2002||4 Ene 2005||Cygnus, Inc.||Electrode with improved signal to noise ratio|
|EP0970719A2||6 Jul 1999||12 Ene 2000||Nitto Denko Corporation||Electrode structure|
|EP1201265A1 *||31 Oct 2000||2 May 2002||Iomed, Inc.||Methods and apparatus for ocular iontophoresis|
|WO1986007269A1 *||10 Jun 1985||18 Dic 1986||Drug Delivery Systems Inc||Programmable control and mounting system for transdermal drug applicator|
|WO1988000846A1 *||22 Jul 1987||11 Feb 1988||Univ New Jersey||Iontotherapeutic device and process and unit dose|
|WO1988003821A1 *||6 Nov 1987||2 Jun 1988||Univ Boston||Electrode assembly for transdermal drug delivery|
|WO1988008729A1 *||6 May 1988||17 Nov 1988||Martin H Newman||Iontophoresis drug delivery system|
|WO1989010690A1 *||27 Abr 1989||16 Nov 1989||Univ South Florida||Method for electrofusing biological particles to tissues|
|WO1990004432A1 *||27 Oct 1989||3 May 1990||Medtronic Inc||Iontophoresis electrode|
|WO1990004433A1 *||27 Oct 1989||3 May 1990||Medtronic Inc||Iontophoresis electrode|
|WO1992004937A1 *||10 Sep 1991||2 Abr 1992||Julian L Henley||Iontophoretic drug delivery apparatus|
|WO2002002182A2||29 Jun 2001||10 Ene 2002||Vyteris Inc||Shelf storage stable iontophoresis reservoir-electrode and iontophoretic system|
|Clasificación de EE.UU.||604/20, 607/153|
|Clasificación internacional||A61N1/04, A61N1/30|
|2 May 1983||AS||Assignment|
Owner name: MOTION CONTROL, INC., 1005 SOUTH 300 WEST, SALT LA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNORS:STEPHEN, ROBERT L.;JACOBSEN, STEPHEN C.;LUNTZ, RICHARD D.;REEL/FRAME:004123/0034
Effective date: 19820204
|18 May 1987||FPAY||Fee payment|
Year of fee payment: 4
|20 May 1991||FPAY||Fee payment|
Year of fee payment: 8
|11 Nov 1992||AS||Assignment|
Owner name: JMW, ACQUISITION CO. A CORP. OF UT
Free format text: MERGER;ASSIGNOR:MOTION CONTROL, INC., A CORP. OF UT;REEL/FRAME:006406/0704
Effective date: 19871203
|1 May 1995||FPAY||Fee payment|
Year of fee payment: 12