US4834984A - Controlled release dihydrocodeine composition - Google Patents
Controlled release dihydrocodeine composition Download PDFInfo
- Publication number
- US4834984A US4834984A US07/052,584 US5258487A US4834984A US 4834984 A US4834984 A US 4834984A US 5258487 A US5258487 A US 5258487A US 4834984 A US4834984 A US 4834984A
- Authority
- US
- United States
- Prior art keywords
- dihydrocodeine
- dosage form
- weight
- released
- hours
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
Abstract
Description
______________________________________ mg/tablet ______________________________________ Dihydrocodeine Tartrate 60.0 Anhydrous Lactose 58.4 Hydroxyethylcellulose 20.4 Cetostearyl alcohol 62.2 Talc 2.0 Magnesium stearate 2.0 ______________________________________
______________________________________ mg/tablet ______________________________________ Dihydrocodeine Tartrate 120.0 Anhydrous Lactose 94.0 Hydroxyethylcellulose 20.0 Cetostearyl alcohol 60.0 Talc 3.0 Magnesium stearate 3.0 ______________________________________
______________________________________ mg/tablet ______________________________________ Dihydrocodeine Tartrate 90.0 Anhydrous Lactose 40.5 Hydroxyethylcellulose 22.5 Cetostearyl Alcohol 67.5 Talc 4.5 Magnesium Stearate 3.75 ______________________________________
______________________________________ mg/tablet ______________________________________ Dihydrocodeine Tartrate 120.0 Anhydrous Lactose 54.0 Hydroxyethylcellulose 30.0 Cetostearyl Alcohol 90.0 Talc 6.0 Magnesium Stearate 5.0 ______________________________________
TABLE 1 ______________________________________ wt. % Dihydrocodeine Tartrate released Time (hr) pH 1.6 pH 4.6 pH 6.5 pH 7.2 ______________________________________ 1 43.8 43.6 43.9 44.1 2 63.4 62.1 62.5 63.1 3 76.7 75.1 75.4 77.6 4 86.3 85.0 84.8 87.4 5 92.1 91.3 91.5 93.8 6 94.9 94.6 94.9 97.6 7 95.9 96.3 96.3 99.7 8 96.0 96.7 97.5 100.0 9 96.3 97.0 98.2 100.5 10 96.3 97.0 98.9 100.6 ______________________________________
TABLE 2 ______________________________________ Time (hr) Wt. % Dihydrocodeine Tartrate released ______________________________________ 1 38.6 2 55.8 3 68.5 4 78.7 5 86.5 6 92.6 7 96.7 8 99.2 ______________________________________
TABLE 3 ______________________________________ Time (hr) Wt. % Dihydrocodeine Tartrate released ______________________________________ 1 31.9 2 48.6 3 60.9 4 70.9 ______________________________________
TABLE 4 ______________________________________ Time (hr) Wt. % Dihydrocodeine Tartrate released ______________________________________ 1 42.1 2 60.6 3 73.6 4 83.7 5 91.2 6 96.5 7 99.3 ______________________________________
TABLE 5 ______________________________________ Mean Plasma Conc. (ng/ml.sup.-1) Time (hr) Example 1 DF118 ______________________________________ 0.25 -- 7 0.50 -- 80 0.75 -- 160 1.0 62 205 1.25 -- 177 1.50 -- 194 2.0 108 183 3.0 130 137 4.0 111 119 5.0 114 -- 6.0 110 73 8.0 85 51 10.0 63 31 12.0 34 23 14.0 27 -- 24.0 6 -- ______________________________________
TABLE 6 ______________________________________ Normal Release Controlled Release Baseline DHC Tartrate DHC Tartrate ______________________________________ Pain scores 0 0 1 1 for 1 5 4 9 Completing 2 26 26 23 Patients 3 15 7 5 4 7 1 1 5 1 0 0 Non- 0 15 15 Completing Patients Total 54 54 54 ______________________________________
TABLE 7 ______________________________________ Normal Release Controlled Release Baseline DHC Tartrate DHC Tartrate ______________________________________ Patients 54 39 38 Completing the study VAS 55.4 42.5 38.3 ______________________________________
Claims (19)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB868614153A GB8614153D0 (en) | 1986-06-10 | 1986-06-10 | Dihydrocodeine composition |
GB8614153 | 1986-09-02 | ||
GB8621206 | 1986-09-02 | ||
GB868621206A GB8621206D0 (en) | 1986-09-02 | 1986-09-02 | Dihydrocodeine composition |
Publications (1)
Publication Number | Publication Date |
---|---|
US4834984A true US4834984A (en) | 1989-05-30 |
Family
ID=26290900
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US07/052,584 Expired - Lifetime US4834984A (en) | 1986-06-10 | 1987-05-19 | Controlled release dihydrocodeine composition |
Country Status (11)
Country | Link |
---|---|
US (1) | US4834984A (en) |
EP (1) | EP0249347B1 (en) |
JP (1) | JP2568202B2 (en) |
AT (1) | ATE107857T1 (en) |
AU (1) | AU600950B2 (en) |
CA (1) | CA1288350C (en) |
DE (1) | DE3750145T2 (en) |
DK (1) | DK175138B1 (en) |
ES (1) | ES2058111T3 (en) |
IE (1) | IE60069B1 (en) |
SG (1) | SG53293G (en) |
Cited By (79)
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US5591452A (en) * | 1993-05-10 | 1997-01-07 | Euro-Celtique, S.A. | Controlled release formulation |
US5672360A (en) * | 1993-11-23 | 1997-09-30 | Purdue Pharma, L.P. | Method of treating pain by administering 24 hour oral opioid formulations |
US5843480A (en) * | 1994-03-14 | 1998-12-01 | Euro-Celtique, S.A. | Controlled release diamorphine formulation |
US5849240A (en) * | 1993-11-23 | 1998-12-15 | Euro-Celtique, S.A. | Method of preparing sustained release pharmaceutical compositions |
US5879705A (en) * | 1993-07-27 | 1999-03-09 | Euro-Celtique S.A. | Sustained release compositions of morphine and a method of preparing pharmaceutical compositions |
US5891471A (en) * | 1993-11-23 | 1999-04-06 | Euro-Celtique, S.A. | Pharmaceutical multiparticulates |
US5958459A (en) * | 1991-12-24 | 1999-09-28 | Purdue Pharma L.P. | Opioid formulations having extended controlled released |
US5958452A (en) * | 1994-11-04 | 1999-09-28 | Euro-Celtique, S.A. | Extruded orally administrable opioid formulations |
US5968551A (en) * | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
US6068855A (en) * | 1994-11-03 | 2000-05-30 | Euro-Celtique S. A. | Pharmaceutical composition containing a fusible carrier and method for producing the same |
US6103261A (en) * | 1993-07-01 | 2000-08-15 | Purdue Pharma Lp | Opioid formulations having extended controlled release |
US6399096B1 (en) | 1995-09-22 | 2002-06-04 | Euro-Celtique S.A. | Pharmaceutical formulation |
US20030069263A1 (en) * | 2001-07-18 | 2003-04-10 | Breder Christopher D. | Pharmaceutical combinations of oxycodone and naloxone |
US6602521B1 (en) * | 1998-09-29 | 2003-08-05 | Impax Pharmaceuticals, Inc. | Multiplex drug delivery system suitable for oral administration |
US20030157168A1 (en) * | 2001-08-06 | 2003-08-21 | Christopher Breder | Sequestered antagonist formulations |
US20030190358A1 (en) * | 1994-11-04 | 2003-10-09 | Benjamin Oshlack | Sustained release hydromorphone formulations exhibiting bimodal characteristics |
US20030215508A1 (en) * | 2000-04-28 | 2003-11-20 | Davis Robert D. | Sustained release of guaifenesin combination drugs |
US20040018233A1 (en) * | 2000-04-28 | 2004-01-29 | Davis Robert D. | Sustained release of guaifenesin |
US20040022851A1 (en) * | 2000-04-28 | 2004-02-05 | Davis Robert D. | Sustained release of guaifenesin combination drugs |
US6696088B2 (en) | 2000-02-08 | 2004-02-24 | Euro-Celtique, S.A. | Tamper-resistant oral opioid agonist formulations |
US6696066B2 (en) | 1997-12-22 | 2004-02-24 | Euro-Celtique S.A. | Opioid agonist/antagonist combinations |
US20040047907A1 (en) * | 2000-10-30 | 2004-03-11 | Benjamin Oshlack | Controlled release hydrocodone formulations |
US20040096500A1 (en) * | 1991-11-27 | 2004-05-20 | Benjamin Oshlack | Controlled release oxycodone compositions |
US20040161382A1 (en) * | 2002-12-13 | 2004-08-19 | Yum Su Il | Oral drug delivery system |
US20040170680A1 (en) * | 2001-05-02 | 2004-09-02 | Benjamin Oshlack | Once-a-day oxycodone formulations |
US6806294B2 (en) | 1998-10-15 | 2004-10-19 | Euro-Celtique S.A. | Opioid analgesic |
US20040266807A1 (en) * | 1999-10-29 | 2004-12-30 | Euro-Celtique, S.A. | Controlled release hydrocodone formulations |
US20050020613A1 (en) * | 2002-09-20 | 2005-01-27 | Alpharma, Inc. | Sustained release opioid formulations and method of use |
US20050063909A1 (en) * | 2001-08-06 | 2005-03-24 | Euro-Celtique, S.A. | Oral dosage form comprising a therapeutic agent and an adverse-effect agent |
US20050192309A1 (en) * | 1997-12-22 | 2005-09-01 | Palermo Philip J. | Method of preventing abuse of opioid dosage forms |
US20050276852A1 (en) * | 2000-04-28 | 2005-12-15 | Adams Laboratories, Inc. | Sustained release formulations of guaifenesin and additional drug ingredients |
US20070185146A1 (en) * | 2004-06-08 | 2007-08-09 | Euro-Celtique S.A. | Opioids for the treatment of the chronic obstructive pulmonary disease (copd) |
US20070275062A1 (en) * | 1993-06-18 | 2007-11-29 | Benjamin Oshlack | Controlled release oxycodone compositions |
US20080020032A1 (en) * | 2006-07-21 | 2008-01-24 | Michael Crowley | Hydrophobic abuse deterrent delivery system for hydromorphone |
US20080075781A1 (en) * | 1992-11-25 | 2008-03-27 | Purdue Pharma Lp | Controlled release oxycodone compositions |
US20080167630A1 (en) * | 2004-09-17 | 2008-07-10 | Durect Corporation | Controlled delivery system |
US20080167533A1 (en) * | 2005-02-28 | 2008-07-10 | Petra Leyendecker | Method and Device for the Assessment of Bowel Function |
US20080233197A1 (en) * | 2006-06-19 | 2008-09-25 | Francis Joseph Matthews | Pharmaceutical compositions |
US20090022798A1 (en) * | 2007-07-20 | 2009-01-22 | Abbott Gmbh & Co. Kg | Formulations of nonopioid and confined opioid analgesics |
WO2009095395A2 (en) | 2008-01-28 | 2009-08-06 | Biovail Laboratories International Srl | Pharmaceutical compositions |
US20090215808A1 (en) * | 2007-12-06 | 2009-08-27 | Su Il Yum | Oral pharmaceutical dosage forms |
US20090317355A1 (en) * | 2006-01-21 | 2009-12-24 | Abbott Gmbh & Co. Kg, | Abuse resistant melt extruded formulation having reduced alcohol interaction |
US20100003322A1 (en) * | 2008-07-03 | 2010-01-07 | Lai Felix S | Enteric coated hydrophobic matrix formulation |
US20100151014A1 (en) * | 2008-12-16 | 2010-06-17 | Alpharma Pharmaceuticals, Llc | Pharmaceutical composition |
US7740881B1 (en) | 1993-07-01 | 2010-06-22 | Purdue Pharma Lp | Method of treating humans with opioid formulations having extended controlled release |
US20100172989A1 (en) * | 2006-01-21 | 2010-07-08 | Abbott Laboratories | Abuse resistant melt extruded formulation having reduced alcohol interaction |
US20110014280A1 (en) * | 2002-09-20 | 2011-01-20 | Garth Boehm | Sequestering subunit and related compositions and methods |
US7914818B2 (en) | 2001-08-06 | 2011-03-29 | Purdue Pharma L.P. | Opioid agonist formulations with releasable and sequestered antagonist |
US20110104214A1 (en) * | 2004-04-15 | 2011-05-05 | Purdue Pharma L.P. | Once-a-day oxycodone formulations |
US20110177133A1 (en) * | 2008-07-07 | 2011-07-21 | Michael Hopp | Use of opioid antagonists for treating urinary retention |
US8182836B2 (en) | 2003-04-08 | 2012-05-22 | Elite Laboratories, Inc. | Abuse-resistant oral dosage forms and method of use thereof |
EP2474308A1 (en) | 2005-06-27 | 2012-07-11 | Valeant International (Barbados) SRL | Pharmaceutical formulations containing bupropion hydrobromide |
US8529948B1 (en) | 2001-08-06 | 2013-09-10 | Purdue Pharma L.P. | Pharmaceutical formulation containing gelling agent |
US8557286B1 (en) | 1999-04-22 | 2013-10-15 | Euroceltique, S.A. | Method for producing a water-insoluble amorphous or partially amorphous controlled release matrix |
US8623418B2 (en) | 2007-12-17 | 2014-01-07 | Alpharma Pharmaceuticals Llc | Pharmaceutical composition |
US8808740B2 (en) | 2010-12-22 | 2014-08-19 | Purdue Pharma L.P. | Encased tamper resistant controlled release dosage forms |
US8846091B2 (en) | 2002-04-05 | 2014-09-30 | Euro-Celtique S.A. | Matrix for sustained, invariant and independent release of active compounds |
US8956644B2 (en) | 2006-11-03 | 2015-02-17 | Durect Corporation | Transdermal delivery systems |
US8969369B2 (en) | 2001-05-11 | 2015-03-03 | Purdue Pharma L.P. | Abuse-resistant controlled-release opioid dosage form |
US9149436B2 (en) | 2003-04-21 | 2015-10-06 | Purdue Pharma L.P. | Pharmaceutical product comprising a sequestered agent |
US9149533B2 (en) | 2013-02-05 | 2015-10-06 | Purdue Pharma L.P. | Tamper resistant pharmaceutical formulations |
US9226907B2 (en) | 2008-02-01 | 2016-01-05 | Abbvie Inc. | Extended release hydrocodone acetaminophen and related methods and uses thereof |
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US9555113B2 (en) | 2013-03-15 | 2017-01-31 | Durect Corporation | Compositions with a rheological modifier to reduce dissolution variability |
US9616055B2 (en) | 2008-11-03 | 2017-04-11 | Durect Corporation | Oral pharmaceutical dosage forms |
US9616030B2 (en) | 2013-03-15 | 2017-04-11 | Purdue Pharma L.P. | Tamper resistant pharmaceutical formulations |
US9662326B2 (en) | 2012-04-17 | 2017-05-30 | Purdue Pharma L.P. | Systems for treating an opioid-induced adverse pharmacodynamic response |
US9849124B2 (en) | 2014-10-17 | 2017-12-26 | Purdue Pharma L.P. | Systems and methods for treating an opioid-induced adverse pharmacodynamic response |
US10071089B2 (en) | 2013-07-23 | 2018-09-11 | Euro-Celtique S.A. | Combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation |
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US10525052B2 (en) | 2004-06-12 | 2020-01-07 | Collegium Pharmaceutical, Inc. | Abuse-deterrent drug formulations |
US10646485B2 (en) | 2016-06-23 | 2020-05-12 | Collegium Pharmaceutical, Inc. | Process of making stable abuse-deterrent oral formulations |
US10668060B2 (en) | 2009-12-10 | 2020-06-02 | Collegium Pharmaceutical, Inc. | Tamper-resistant pharmaceutical compositions of opioids and other drugs |
US11083796B2 (en) | 2005-07-26 | 2021-08-10 | Durect Corporation | Peroxide removal from drug delivery vehicle |
US11278506B2 (en) | 2015-10-09 | 2022-03-22 | Rb Health (Us) Llc | Pharmaceutical formulation |
US11400019B2 (en) | 2020-01-13 | 2022-08-02 | Durect Corporation | Sustained release drug delivery systems with reduced impurities and related methods |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8813064D0 (en) * | 1988-06-02 | 1988-07-06 | Euro Celtique Sa | Controlled release dosage forms having defined water content |
IL109944A (en) † | 1993-07-01 | 1998-12-06 | Euro Celtique Sa | Sustained release dosage unit forms containing morphine and a method of preparing these sustained release dosage unit forms |
DE19710008A1 (en) * | 1997-03-12 | 1998-09-17 | Basf Ag | Solid, at least two-phase formulations of a sustained-release opioid analgesic |
SK286107B6 (en) * | 2002-04-12 | 2008-03-05 | Zentiva, A. S. | Analgesically active peroral therapeutic composition with controlled release of an opioid active substance and method for the preparation thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB821790A (en) * | 1956-11-20 | 1959-10-14 | Smith Kline French Lab | Method of preparing sustained release particles and the product of the method |
GB935426A (en) * | 1960-04-19 | 1963-08-28 | Ici Ltd | Compositions comprising or consisting of a coated chloroquine or amodiaquine salt |
GB1125882A (en) * | 1963-09-18 | 1968-09-05 | Key Pharma | Improvements in a delayed and sustained release type pharmaceutical preparation |
US4629620A (en) * | 1984-09-05 | 1986-12-16 | Ab Ferrosan | Membrane-coated sustained-release tablets and method |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB907021A (en) * | 1958-11-24 | 1962-09-26 | Wallace & Tiernan Inc | Pharmaceutical compositions |
GB1405088A (en) * | 1971-06-03 | 1975-09-03 | Mundipharma Ag | Slow release formulation |
IE49324B1 (en) * | 1979-12-19 | 1985-09-18 | Euro Celtique Sa | Controlled release compositions |
US4369172A (en) * | 1981-12-18 | 1983-01-18 | Forest Laboratories Inc. | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose |
FR2585246A1 (en) * | 1985-07-26 | 1987-01-30 | Cortial | PROCESS FOR OBTAINING SOLID PHARMACEUTICAL FORMS WITH PROLONGED RELEASE |
-
1987
- 1987-05-18 EP EP87304363A patent/EP0249347B1/en not_active Revoked
- 1987-05-18 ES ES87304363T patent/ES2058111T3/en not_active Expired - Lifetime
- 1987-05-18 AT AT87304363T patent/ATE107857T1/en not_active IP Right Cessation
- 1987-05-18 DE DE3750145T patent/DE3750145T2/en not_active Revoked
- 1987-05-19 US US07/052,584 patent/US4834984A/en not_active Expired - Lifetime
- 1987-06-04 CA CA000538889A patent/CA1288350C/en not_active Expired - Lifetime
- 1987-06-08 JP JP62143019A patent/JP2568202B2/en not_active Expired - Lifetime
- 1987-06-09 DK DK198702930A patent/DK175138B1/en not_active IP Right Cessation
- 1987-06-09 IE IE152687A patent/IE60069B1/en not_active IP Right Cessation
- 1987-06-10 AU AU74073/87A patent/AU600950B2/en not_active Expired
-
1993
- 1993-04-24 SG SG532/93A patent/SG53293G/en unknown
Patent Citations (4)
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GB821790A (en) * | 1956-11-20 | 1959-10-14 | Smith Kline French Lab | Method of preparing sustained release particles and the product of the method |
GB935426A (en) * | 1960-04-19 | 1963-08-28 | Ici Ltd | Compositions comprising or consisting of a coated chloroquine or amodiaquine salt |
GB1125882A (en) * | 1963-09-18 | 1968-09-05 | Key Pharma | Improvements in a delayed and sustained release type pharmaceutical preparation |
US4629620A (en) * | 1984-09-05 | 1986-12-16 | Ab Ferrosan | Membrane-coated sustained-release tablets and method |
Cited By (329)
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---|---|---|---|---|
US20040185098A1 (en) * | 1991-11-27 | 2004-09-23 | Benjamin Oshlack | Controlled release oxycodone compositions |
US20060057210A1 (en) * | 1991-11-27 | 2006-03-16 | Purdue Pharma L.P. | Controlled release oxycodone compositions |
EP1327446B2 (en) † | 1991-11-27 | 2007-08-22 | The Purdue Pharma Company | Controlled release oxycodone compositions |
US20040096500A1 (en) * | 1991-11-27 | 2004-05-20 | Benjamin Oshlack | Controlled release oxycodone compositions |
US7270831B2 (en) | 1991-12-24 | 2007-09-18 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
US20090068269A1 (en) * | 1991-12-24 | 2009-03-12 | Purdue Pharma L.P. | Orally adminstrable opioid formulations having extended duration of effect |
US5958459A (en) * | 1991-12-24 | 1999-09-28 | Purdue Pharma L.P. | Opioid formulations having extended controlled released |
US20030180361A1 (en) * | 1991-12-24 | 2003-09-25 | Benjamin Oshlack | Orally administrable opioid formulations having extended duration of effect |
US6294195B1 (en) | 1991-12-24 | 2001-09-25 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
US20040121001A1 (en) * | 1991-12-24 | 2004-06-24 | Benjamin Oshlack | Orally adminstrable opioid formulations having extended duration of effect |
US5968551A (en) * | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
US6572885B2 (en) | 1991-12-24 | 2003-06-03 | Euro-Celtique, S.A. | Orally administrable opioid formulations having extended duration of effect |
US20080181941A1 (en) * | 1991-12-24 | 2008-07-31 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
US20100092570A1 (en) * | 1992-11-25 | 2010-04-15 | Purdue Pharma L.P. | Controlled release oxycodone compositions |
US20080075781A1 (en) * | 1992-11-25 | 2008-03-27 | Purdue Pharma Lp | Controlled release oxycodone compositions |
US7074430B2 (en) | 1993-05-10 | 2006-07-11 | Euro-Celtique S.A. | Controlled release tramadol tramadol formulation |
US20090117191A1 (en) * | 1993-05-10 | 2009-05-07 | Purdue Pharma Products L.P. | Controlled release tramadol formulations |
US6254887B1 (en) * | 1993-05-10 | 2001-07-03 | Euro-Celtique S.A. | Controlled release tramadol |
US5591452A (en) * | 1993-05-10 | 1997-01-07 | Euro-Celtique, S.A. | Controlled release formulation |
US6326027B1 (en) * | 1993-05-10 | 2001-12-04 | Euro-Celtique S.A. | Controlled release formulation |
US20060269603A1 (en) * | 1993-05-10 | 2006-11-30 | Euro-Celtique S.A. | Controlled release tramadol formulations |
US20100034876A1 (en) * | 1993-06-18 | 2010-02-11 | Purdue Pharma L.P. | Controlled release oxycodone compositions |
US20070275062A1 (en) * | 1993-06-18 | 2007-11-29 | Benjamin Oshlack | Controlled release oxycodone compositions |
US6143322A (en) * | 1993-07-01 | 2000-11-07 | Purdue Pharma L.P. | Method of treating humans with opioid formulations having extended controlled release |
US7740881B1 (en) | 1993-07-01 | 2010-06-22 | Purdue Pharma Lp | Method of treating humans with opioid formulations having extended controlled release |
US6103261A (en) * | 1993-07-01 | 2000-08-15 | Purdue Pharma Lp | Opioid formulations having extended controlled release |
US5879705A (en) * | 1993-07-27 | 1999-03-09 | Euro-Celtique S.A. | Sustained release compositions of morphine and a method of preparing pharmaceutical compositions |
US6143328A (en) * | 1993-07-27 | 2000-11-07 | Euro-Celtique, S.A. | Sustained release compositions and a method of preparing pharmaceutical compositions |
US5849240A (en) * | 1993-11-23 | 1998-12-15 | Euro-Celtique, S.A. | Method of preparing sustained release pharmaceutical compositions |
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AU7407387A (en) | 1987-12-17 |
ATE107857T1 (en) | 1994-07-15 |
EP0249347B1 (en) | 1994-06-29 |
DK293087D0 (en) | 1987-06-09 |
DE3750145T2 (en) | 1994-11-03 |
JPS62292720A (en) | 1987-12-19 |
DE3750145D1 (en) | 1994-08-04 |
DK293087A (en) | 1987-12-11 |
ES2058111T3 (en) | 1994-11-01 |
IE871526L (en) | 1987-12-10 |
IE60069B1 (en) | 1994-06-01 |
EP0249347A3 (en) | 1988-03-23 |
EP0249347A2 (en) | 1987-12-16 |
AU600950B2 (en) | 1990-08-30 |
DK175138B1 (en) | 2004-06-14 |
SG53293G (en) | 1993-06-25 |
CA1288350C (en) | 1991-09-03 |
JP2568202B2 (en) | 1996-12-25 |
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