US4855326A - Rapidly dissoluble medicinal dosage unit and method of manufacture - Google Patents
Rapidly dissoluble medicinal dosage unit and method of manufacture Download PDFInfo
- Publication number
- US4855326A US4855326A US07/169,838 US16983888A US4855326A US 4855326 A US4855326 A US 4855326A US 16983888 A US16983888 A US 16983888A US 4855326 A US4855326 A US 4855326A
- Authority
- US
- United States
- Prior art keywords
- medicament
- spun
- fibers
- dosage unit
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
- A61K8/027—Fibers; Fibrils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L13/00—Meat products; Meat meal; Preparation or treatment thereof
- A23L13/40—Meat products; Meat meal; Preparation or treatment thereof containing additives
- A23L13/42—Additives other than enzymes or microorganisms in meat products or meat meals
- A23L13/43—Addition of vegetable fats or oils; Addition of non-meat animal fats or oils; Addition of fatty acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/25—Agglomeration or granulation by extrusion or by pressing, e.g. through small holes, through sieves or between surfaces
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/445—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof aromatic, i.e. the carboxylic acid directly linked to the aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
Abstract
Description
TABLE I ______________________________________ Sample mg of Acetaminophen per Percent Acetaminophen No. gram of fibrous product per dosage unit ______________________________________ 1 54.6 mg 91.0% 2 57.0 mg 95.0% 3 52.2 mg 87.0% ______________________________________
TABLE II ______________________________________ mg of diethylcarbamazine Percent of Sample citrate per gram of diethylcarbamazine No. fibrous product citrate per dosage unit ______________________________________ 1 174 mg 87% 2 166 mg 83% 3 188 mg 94% ______________________________________
TABLE III __________________________________________________________________________ TEST DRUG SUGAR SOLVENT NO. (gms) (gms) (ml) DRYING REMARK __________________________________________________________________________ 1 A-8 100 12 2 D-10 50 15 3 D-10 50 H.sub.2 O - 5 45-60° C. Never obtained dry mass 4 D-10 50 0.4 g PVP 40-45° C. in 15 ml for 1/2 hr. IPA 5 A-5 50 12 6 Coated 50 12 A-5 7 A-5 50 IPA-12 + 4 drops of peppermint oil 8 D-10 50 15 9 A-5 50 15 micron- ized 10 M-1.182 100 10 11 A-8 100 12 12 C-0.4 100 10 13 P-3.75 + 295.65 20 C-0.6 14 C-0.6 299.4 20 15 Z-5 95 Mixed drug and sugar and spun fibers 16 C-0.4 99.6 10 __________________________________________________________________________
TABLE IV ______________________________________ QUANTITIES DRUG DRUG SUGAR ______________________________________ acetaminophen 4 gm 50 gm phenylpropanolamine 300 mg 50 gm chlorpheniramine maleate 100 mg 50 gm aspirin* 4 gm 50 gm ______________________________________ *Some degradation of the aspirin occurred as evidenced by excessive smoking and the characteristic odor of acetic acid. However, the fiber product had the characteristic taste of aspirin.
TABLE V ______________________________________ MELTING POINT SUGAR °C. °F. ______________________________________ maltose R 103 217.4 fructose USP 105 221.0 sorbitol USP 110 230.0 dextrose USP 146 294.8 mannitol USP 166 330.8 sucrose USP 186 366.8 lactose R 202 395.6 ______________________________________
TABLE VI ______________________________________ CATEGORY FORM ______________________________________ ACNE PREPARATIONS A,C ANALGESICS A,B,C,D ANTIPYRETICS A,C,D ANTACIDS A ANTIFLATULENTS A ANTHELMINTICS A,D ANTIANGINAL A,D ANTIANXIETY A,B,D ANTI-ARRYTHYMICS A,D ANTIARTHRITICS A,B,C,D ANTICOAGULANTS/THROMBOLYTICS A,D ANTICONVULSANTS/ANTIPARKINSON A,D ANTIDEPRESSANTS A,D ANTIDIARRHEAL/ELECTROLYTE SOLUTIONS A,D ANTIFUNGAL A,B,C,D ANTITRICHOMONAL A,B,C,D ANTIVIRAL AGENTS A,B,C,D ANTIGOUT A,B,C,D ANTIHISTAMINES A,B,C,D ANTIPRURITICS A,B,C,D ANTIHYPERTENSIVES A,D ANTIINFECTIVES (AMINOGLYCOSIDES, SULFONAMIDES, CEPHELOSPORINS, PENICILLINS, ERYTHROMYCINS, TETRACYCLINES) SYSTEMIC OF ABOVE A,D LOCAL OF ABOVE A,B,C,D ANTIMIGRAINES A,B,D ANTINAUSEANTS/ANTIEMETICS A,B,D ANTINEOPLASTICS A,D ANTIULCER A,D ANTIREFLUX A,D ANTISPASMODIC A,D BRONCHIAL DILATERS/ANTIASTHMATICS A,D CARDIAC AGENTS A,D CONTRACEPTIVES A,D HORMONALS A,B,C,D STEROIDS A,B,C,D COUGH/COLD REMEDIES A,D DIURETICS A,D HYPOGLYCEMICS A,D HYPOLIPIDEMICS A,D LAXATIVES A TRANQUILIZERS MAJOR & MINOR A,B,D MUSCLE RELAXANTS A,D OPTHALMIC PREPARATIONS A,C,D POTASSIUM SUPPLEMENTS A,D SEDATIVES AND HYPNOTICS A,D URINARY ANTINFECTIVES & OTHER URINARY AGENTS A,D VITAMINS AND MINERALS A,D ______________________________________
Claims (59)
Priority Applications (26)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/169,838 US4855326A (en) | 1987-04-20 | 1988-03-18 | Rapidly dissoluble medicinal dosage unit and method of manufacture |
IL86053A IL86053A (en) | 1987-04-20 | 1988-04-13 | Rapidly dissolving pharmaceutical composition comprising a medicament incorporated in spun fibers |
HU883238A HU207941B (en) | 1987-04-20 | 1988-04-14 | Quickly dissolving pharmaceutical dosage-unit and process for producing them |
PCT/US1988/001199 WO1988008298A1 (en) | 1987-04-20 | 1988-04-14 | Rapidly dissoluble medicinal dosage unit and method of manufacture |
KR1019880701693A KR960014868B1 (en) | 1987-04-20 | 1988-04-14 | Moderated spun fibrous medicinal dosage unit and method of manufacture thereof |
AT88904094T ATE102021T1 (en) | 1987-04-20 | 1988-04-14 | RAPID RELEASE DRUG DOSING UNIT AND METHOD OF MANUFACTURE. |
DE198888904094T DE357665T1 (en) | 1987-04-20 | 1988-04-14 | QUICK-RELEASE MEDICINE DOSING UNIT AND METHOD FOR PRODUCTION. |
AU17104/88A AU609137B2 (en) | 1987-04-20 | 1988-04-14 | Rapidly dissoluble medicinal dosage unit and method of manufacture |
EP88904094A EP0357665B1 (en) | 1987-04-20 | 1988-04-14 | Rapidly dissoluble medicinal dosage unit and method of manufacture |
DE3888177T DE3888177T2 (en) | 1987-04-20 | 1988-04-14 | QUICK-DISCONNECTED MEDICINE DOSING UNIT AND METHOD FOR PRODUCTION. |
JP63503773A JP2869079B2 (en) | 1987-04-20 | 1988-04-14 | Rapidly dissolving fibrous pharmaceutical composition and method for producing the same |
CA000564394A CA1315679C (en) | 1987-04-20 | 1988-04-18 | Rapidly dissoluble medicinal dosage unit and method of manufacture |
US07/283,742 US5011532A (en) | 1988-03-18 | 1988-12-13 | Dispersed systems and method of manufacture |
US07/392,427 US5028632A (en) | 1987-04-20 | 1989-08-10 | Taste masked medicated pharmaceutical |
US07/851,650 US5236734A (en) | 1987-04-20 | 1992-03-16 | Method of preparing a proteinaceous food product containing a melt spun oleaginous matrix |
US07/879,788 US5238696A (en) | 1987-04-20 | 1992-05-06 | Method of preparing a frozen comestible |
US08/081,338 US5370881A (en) | 1987-04-20 | 1992-10-30 | Water-soluble delivery systems for hydrophobic liquids |
US08/331,628 US5516537A (en) | 1987-04-20 | 1993-05-04 | Frozen comestibles |
US08/071,176 US5422136A (en) | 1987-04-20 | 1993-06-02 | Starch-based food enhancing ingredient |
US08/080,479 US5286513A (en) | 1987-04-20 | 1993-06-22 | Proteinaceous food product containing a melt spun oleaginous matrix |
US08/163,120 US5374447A (en) | 1987-04-20 | 1993-12-06 | Method of preparing a reduced-fat meat product |
US08/232,835 US5456932A (en) | 1987-04-20 | 1994-04-22 | Method of converting a feedstock to a shearform product and product thereof |
US08/289,926 US5431950A (en) | 1987-04-20 | 1994-08-12 | Reduced-fat meat product containing a melt spun oleaginous matrix |
US08/408,205 US5472731A (en) | 1987-04-20 | 1995-03-22 | Protein based food product |
US08/410,333 US5490993A (en) | 1987-04-20 | 1995-03-24 | Method of preparing a proteinaceous food product containing a melt spun matrix and product thereof |
US08/452,303 US5503862A (en) | 1987-04-20 | 1995-05-26 | Method of subjecting a protein-containing material to flash flow processing and product thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4037187A | 1987-04-20 | 1987-04-20 | |
US07/169,838 US4855326A (en) | 1987-04-20 | 1988-03-18 | Rapidly dissoluble medicinal dosage unit and method of manufacture |
Related Parent Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US4037187A Continuation-In-Part | 1987-04-20 | 1987-04-20 | |
US4037187A Continuation | 1987-04-20 | 1987-04-20 | |
US07/169,914 Continuation-In-Part US4873085A (en) | 1987-04-20 | 1988-03-18 | Spun fibrous cosmetic and method of use |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US07/283,742 Continuation-In-Part US5011532A (en) | 1987-04-20 | 1988-12-13 | Dispersed systems and method of manufacture |
US07/325,643 Continuation-In-Part US5034421A (en) | 1987-04-20 | 1989-03-20 | Moderated spun fibrous system and method of manufacture |
US07/602,485 Continuation-In-Part US5096492A (en) | 1987-04-20 | 1990-10-24 | Dispersed systems and method of manufacture |
Publications (1)
Publication Number | Publication Date |
---|---|
US4855326A true US4855326A (en) | 1989-08-08 |
Family
ID=26717014
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US07/169,838 Expired - Lifetime US4855326A (en) | 1987-04-20 | 1988-03-18 | Rapidly dissoluble medicinal dosage unit and method of manufacture |
Country Status (10)
Country | Link |
---|---|
US (1) | US4855326A (en) |
EP (1) | EP0357665B1 (en) |
JP (1) | JP2869079B2 (en) |
KR (1) | KR960014868B1 (en) |
AU (1) | AU609137B2 (en) |
CA (1) | CA1315679C (en) |
DE (1) | DE3888177T2 (en) |
HU (1) | HU207941B (en) |
IL (1) | IL86053A (en) |
WO (1) | WO1988008298A1 (en) |
Cited By (143)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990006969A1 (en) * | 1988-12-13 | 1990-06-28 | Fuisz Technologies Ltd. | Dispersed systems and method of manufacture |
WO1990011017A1 (en) * | 1989-03-20 | 1990-10-04 | Fuisz Pharmaceutical Ltd. | A moderated spun fibrous system and method of manuacture |
US4997856A (en) * | 1987-04-20 | 1991-03-05 | Fuisz Pharmaceutical Ltd. | Method of producing compacted dispersable systems |
US5028632A (en) * | 1987-04-20 | 1991-07-02 | Fuisz Pharmaceutical Ltd. | Taste masked medicated pharmaceutical |
WO1992006603A1 (en) * | 1990-10-10 | 1992-04-30 | Fuisz Technologies Ltd. | Taste masked medicated floss |
WO1992020329A1 (en) * | 1991-05-17 | 1992-11-26 | Fuisz Technologies Ltd. | Enzyme systems |
WO1993008699A1 (en) * | 1991-11-04 | 1993-05-13 | Fuisz Technologies Ltd. | Water-soluble delivery systems for hydrophobic liquids |
WO1993011750A1 (en) * | 1991-12-17 | 1993-06-24 | Fuisz Technologies Ltd. | Ulcer prevention and treatment composition and method |
US5236734A (en) * | 1987-04-20 | 1993-08-17 | Fuisz Technologies Ltd. | Method of preparing a proteinaceous food product containing a melt spun oleaginous matrix |
US5238696A (en) * | 1987-04-20 | 1993-08-24 | Fuisz Technologies Ltd. | Method of preparing a frozen comestible |
US5268110A (en) * | 1991-05-17 | 1993-12-07 | Fuisz Technologies Ltd. | Oil removing method |
US5279849A (en) * | 1992-05-12 | 1994-01-18 | Fuisz Technologies Ltd. | Dispersible polydextrose, compositions containing same and method for the preparation thereof |
US5286513A (en) * | 1987-04-20 | 1994-02-15 | Fuisz Technologies Ltd. | Proteinaceous food product containing a melt spun oleaginous matrix |
US5288508A (en) * | 1992-03-20 | 1994-02-22 | Fuisz Technologies, Ltd. | Delivery systems containing elastomer solvents subjected to flash flow |
EP0601965A2 (en) * | 1992-10-23 | 1994-06-15 | Fuisz Technologies Ltd. | Process for making shearform matrix |
US5346377A (en) * | 1993-10-07 | 1994-09-13 | Fuisz Technologies Ltd. | Apparatus for flash flow processing having feed rate control |
US5348758A (en) * | 1992-10-20 | 1994-09-20 | Fuisz Technologies Ltd. | Controlled melting point matrix formed with admixtures of a shearform matrix material and an oleaginous material |
US5370881A (en) * | 1987-04-20 | 1994-12-06 | Fuisz Technologies Ltd. | Water-soluble delivery systems for hydrophobic liquids |
US5387431A (en) * | 1991-10-25 | 1995-02-07 | Fuisz Technologies Ltd. | Saccharide-based matrix |
EP0646650A2 (en) | 1993-09-10 | 1995-04-05 | Fuisz Technologies Ltd. | New spheroidal crystal sugar and method of manufacuture |
US5407676A (en) * | 1990-12-14 | 1995-04-18 | Fuisz Technologies Ltd. | Hydrophilic form of perfluoro compounds and a method of manufacture |
US5427804A (en) * | 1992-03-05 | 1995-06-27 | Fuisz Technologies Ltd. | Low-fat edible proteins with maltodextrins and low-saturate oils |
US5427811A (en) * | 1992-09-30 | 1995-06-27 | Fuisz Technologies Ltd. | Method and apparatus for spinning thermo-flow materials |
EP0667147A2 (en) * | 1994-02-10 | 1995-08-16 | Fuisz Technologies Ltd. | Process and apparatus for making tablets and tablets made therefrom |
US5445769A (en) * | 1994-06-27 | 1995-08-29 | Fuisz Technologies Ltd. | Spinner head for flash flow processing |
US5447423A (en) * | 1993-03-30 | 1995-09-05 | Fuisz Technologies, Ltd. | Apparatus for transforming the physical structure of thermo-flow materials |
US5456932A (en) * | 1987-04-20 | 1995-10-10 | Fuisz Technologies Ltd. | Method of converting a feedstock to a shearform product and product thereof |
US5472731A (en) * | 1987-04-20 | 1995-12-05 | Fuisz Technologies Ltd. | Protein based food product |
WO1995034293A1 (en) * | 1994-06-14 | 1995-12-21 | Fuisz Technologies Ltd. | Process and apparatus for making rapidly dissolving dosage units and product therefrom |
WO1996003894A1 (en) * | 1994-08-05 | 1996-02-15 | Fuisz Technologies Ltd. | Comestibles containing stabilized highly odorous flavor component delivery systems |
US5501858A (en) * | 1992-05-12 | 1996-03-26 | Fuisz Technologies Ltd. | Rapidly dispersable compositions containing polydextrose |
EP0709035A2 (en) | 1994-10-28 | 1996-05-01 | Fuisz Technologies Ltd. | Method and apparatus for spinning meltable material |
US5516537A (en) * | 1987-04-20 | 1996-05-14 | Fuisz Technologies Ltd. | Frozen comestibles |
EP0711547A1 (en) * | 1994-11-04 | 1996-05-15 | Fuisz Technologies Ltd. | Delivery of controlled-release system(s) with shearform matrix |
US5518730A (en) | 1992-06-03 | 1996-05-21 | Fuisz Technologies Ltd. | Biodegradable controlled release flash flow melt-spun delivery system |
US5549917A (en) * | 1994-07-01 | 1996-08-27 | Fuisz Technologies Ltd. | Flash flow formed solloid delivery systems |
US5576042A (en) * | 1991-10-25 | 1996-11-19 | Fuisz Technologies Ltd. | High intensity particulate polysaccharide based liquids |
US5587198A (en) * | 1995-05-31 | 1996-12-24 | Fuisz Technologies Ltd. | Positive hydration method of preparing confectionery and product therefrom |
US5593502A (en) * | 1993-10-07 | 1997-01-14 | Fuisz Technologies Ltd. | Method of making crystalline sugar and products resulting therefrom |
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US5622719A (en) * | 1993-09-10 | 1997-04-22 | Fuisz Technologies Ltd. | Process and apparatus for making rapidly dissolving dosage units and product therefrom |
US5633015A (en) * | 1992-09-03 | 1997-05-27 | Janssen Pharmaceutica Nv | Beads having a core coated with an antifungal and a polymer |
US5641513A (en) * | 1993-08-30 | 1997-06-24 | Warner-Lambert Company | Tablet coating method |
US5705183A (en) * | 1994-11-16 | 1998-01-06 | Phillips Company | Cotton candy coated medication and a method for making and administering the same |
US5728397A (en) * | 1992-05-12 | 1998-03-17 | Fuisz Technologies Ltd. | Polydextrose product and process |
US5779946A (en) * | 1993-04-19 | 1998-07-14 | Fuisz Technologies Ltd. | Method for spin processing material having temperature feedback control |
US5834033A (en) * | 1997-05-12 | 1998-11-10 | Fuisz Technologies Ltd. | Apparatus for melt spinning feedstock material having a flow restricting ring |
US5843922A (en) * | 1994-07-29 | 1998-12-01 | Fuisz Technologies Ltd. | Preparation of oligosaccharides and products therefrom |
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US5876759A (en) * | 1993-07-27 | 1999-03-02 | Mcneil-Ppc, Inc. | Rapidly disintegrating pharmaceutical dosage form and process for preparation thereof |
US5935600A (en) * | 1993-09-10 | 1999-08-10 | Fuisz Technologies Ltd. | Process for forming chewable quickly dispersing comestible unit and product therefrom |
US5939120A (en) * | 1997-11-07 | 1999-08-17 | Fuisz Technologies Ltd. | Externally heated material processing apparatus and method |
US5939091A (en) * | 1997-05-20 | 1999-08-17 | Warner Lambert Company | Method for making fast-melt tablets |
US6020002A (en) * | 1994-06-14 | 2000-02-01 | Fuisz Technologies Ltd. | Delivery of controlled-release system(s) |
US6028222A (en) * | 1996-08-05 | 2000-02-22 | Scr Pharmatop | Stable liquid paracetamol compositions, and method for preparing same |
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US6471992B1 (en) | 1997-02-20 | 2002-10-29 | Therics, Inc. | Dosage form exhibiting rapid disperse properties, methods of use and process for the manufacture of same |
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Also Published As
Publication number | Publication date |
---|---|
AU609137B2 (en) | 1991-04-26 |
CA1315679C (en) | 1993-04-06 |
IL86053A (en) | 1991-09-16 |
DE3888177D1 (en) | 1994-04-07 |
KR890701082A (en) | 1989-12-19 |
JP2869079B2 (en) | 1999-03-10 |
DE3888177T2 (en) | 1994-06-09 |
WO1988008298A1 (en) | 1988-11-03 |
EP0357665A1 (en) | 1990-03-14 |
HU207941B (en) | 1993-07-28 |
EP0357665B1 (en) | 1994-03-02 |
KR960014868B1 (en) | 1996-10-21 |
JPH03500164A (en) | 1991-01-17 |
IL86053A0 (en) | 1988-09-30 |
HUT54491A (en) | 1991-03-28 |
EP0357665A4 (en) | 1990-09-05 |
AU1710488A (en) | 1988-12-02 |
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