|Número de publicación||US4863722 A|
|Tipo de publicación||Concesión|
|Número de solicitud||US 07/007,511|
|Fecha de publicación||5 Sep 1989|
|Fecha de presentación||28 Ene 1987|
|Fecha de prioridad||28 Ene 1987|
|Número de publicación||007511, 07007511, US 4863722 A, US 4863722A, US-A-4863722, US4863722 A, US4863722A|
|Inventores||Murray W. Rosenthal|
|Cesionario original||Jeffrey Martin, Inc.|
|Exportar cita||BiBTeX, EndNote, RefMan|
|Citas de patentes (11), Citada por (22), Clasificaciones (12), Eventos legales (6)|
|Enlaces externos: USPTO, Cesión de USPTO, Espacenet|
The process of cleaning human dentition with a toothbrush and dentifrice is an important function for both physiological and cosmetic purposes. Human teeth are exposed to a constant flow of saliva and rapidly accumulate a strongly-adherent proteinaceous salivary pellicle which is then colonized by oral bacterial to give rise to dental plaque. Both pellicle and plaque can be stained by a large number of intrinsic and extrinsic materials in the mouth, and if not removed regularly by the mechanical action of toothbrush and dentifrice, can become stained and unsightly. Of equal or greater importance, the presence of plaque on human teeth can lead to serious dental diseases. Some types of plaque contain bacteria which are acid-producing from the degradation of orally ingested carbohydrate foods, and the acid thus produced, along with virulent bacterial cells, can penetrate tooth structure and cause dental decay (caries). Other types of plaque contain bacteria which secrete enzymes that can attack the connective tissues of the human gingiva with the sequelae of tissue inflammation, bleeding, separation of the gingival tissue from the necks of teeth, the development of gingivitis and periodontal disease and in time, the restoration of supporting bony structure followed by the loss of teeth.
Brushing the teeth with a toothbrush alone does not keep the teeth free of stain. Similarly, the use of a dentifrice which lacks adequate abrasive action can result in inadequate cleaning with the subsequent development of cosmetically unacceptable stains.
It has been widely accepted that dentifrices should contain one or more abrasive agents to assist in the cleaning of the dentition. The question of a proper balance of dentifrice abrasivity and safety for human teeth, to avoid excessive wear and erosion of tooth structure, is a subject which has received continuing attention by dental authorities. Based on a comparison of products being tested against a standard, a reading of 250 or less by the Radioactive Dentin Abrasion (RDA) procedure is considered an acceptable level of abrasivity for a dentifrice. The procedure relies on an in vitro technique for irradiating human dentin and then measuring the amount of irradiated dentin removed from the teeth by a dentifrice when brushed on prepared human dentin specimens under standardized and reproducible brushing conditions.
It has been believed heretofore that the cleansing power of a dentifrice is directly proportional to its abrasive level, and that the best-cleaning dentifrices are also the most abrasive products. However, it has been discovered that this parallel relationship is not wholly accurate and it is an objective of this invention to demonstrate that exceptionally powerful cleaning systems can be prepared which have fully acceptable levels of abrasivity as measured by the RDA procedure.
The abrasive characteristics of dentifrice abrasive agents are related to the chemical nature of agents used, their particle size, their hardness and the shape of individual particles.
In accordance with this invention, generally stated, a superior cleansing oral composition in the form of a dentifrice gel or paste is provided, comprising:
(a) From about 0.02% to about 0.08% of a zirconium silicate of a mean particle size of 0.60-0.75 microns in which no more than 25% of the particles are smaller than 0.4 microns and no more than 25% of the particles are larger than 1.0 micron
(b) At least 22%, and preferably from 22% to 50%, of synthetic, amorphous, precipitated hydrated silica, of at least 99% pure silicon dioxide (dry basis) content in which the mean particle size is in the range of 6-12 microns.
(c) The balance of the dentifrice gel or paste consisting of other ingredients commonly used in typical dentifrice compositions which may include but are not limited to water, humectants, flavors, sweeteners, foaming agents, colors, opacifiers, gums, thickeners and one or more pharmacologically active ingredients selected from the classes of water soluble fluorides, plaque and calculus inhibitors, antimicrobial compounds, deodorant ingredients, and non-steroidal anti-inflammatory drugs.
All percentages given are percentages by weight of the fully compounded dentifrice gel or paste.
It is the purpose of this invention to provide novel dentifrice compositions intended for application to the oral dentition with a toothbrush, which compositions possess superior cleansing properties against stains on teeth, more particularly those arising from tobacco tars, coffee, tea and other stains of extrinsic origin. Such compositions are also highly effective in the cleaning and removal of deposits which arise from biological activity within the oral cavity, such as are associated with the production and deposition of dental pellicle, dental plaque and dental calculus.
A particular feature of the invention is to employ within specified levels, combinations of a fine particle, synthetic, precipitated, hydrated silica and a zirconium silicate of controlled particle size. Such mixtures may also be employed with a complex zinc salt chemically identified as an alkali metal zinc citrate or with other pharmacologically active agents. Although each of these materials has been described in previous patents as a dentifrice ingredient, it was entirely unexpected that their use together, within the concentrations and particle sizes herein specified, would produce cleaning efficiency at heretofore unknown levels of efficacy.
U.S. Pat. Nos. 3,257,282, 3,330,732, 3,450,813 and 3,541,017 have described the incorporation of zirconium silicate in compositions for cleaning both natural and artificial teeth. However, the particle size of the zirconium silicate characterized in those patents may range as high as 75 microns and the concentration prescribed for use in compositions for cleaning natural or artificial teeth is described as being at least 0.5% of the total cleaning composition. U.S. Pat. No. 3,450,813, for example, suggests that zirconium silicate of the form there described enhances the dental cleaning and polishing capabilities of agents such as (certain calcium and sodium compounds and resins, or talc) but recommends the use of more than 1.6% of zirconium silicate in the dentifrice, "with the best results being obtained where the overall compositions comprise in excess of about 10% and preferably at least about 20% zirconium silicate."
It has been discovered, however, that if zirconium silicate of an extremely fine, but controlled, particle-size, is employed in suitable compositions, concentrations as low as 0.02%, and preferably, in the range of 0.02%-0.08% of the dentifrice composition are extremely effective as dentifrice cleaning adjuvants when used with a suitable silica abrasive agent and other dentifrice components.
The specific mean particle size of such zirconium silicate should range from 0.60 to 0.75 microns, and more specifically, no more than 25% of the particles should be smaller than 0.4 microns and no more than 25% of the particles should be larger than 1.0 micron. As a consequence of the low and controlled particle-size, dentifrices made with 0.02%-0.08% of this specific type of zirconium silicate have exceptional cleansing effectiveness and only moderate abrasivity. Dentifrices made with zirconium silicate of a mean particle size significantly larger than that described in the present invention have abrasivity characteristics which may cause excessive wear on the human dentition, while dentifrices made with zirconium silicate of a mean article size significantly smaller than that described herein are devoid of the outstanding cleaning effectiveness exhibited by compositions of this invention.
It also has been discovered that the utilization of 0.02%-0.08% zirconium silicate of an average particle size of 0.60 to 0.75 microns in dentifrice compositions wherein the bulk of the dentifrice abrasive system is a mixture of synthetic, amorphous precipitated hydrated silicas, in a concentration of from 22% to 50%, does not significantly impair the transparency of the dentifrice if it should be desired to formulate a transparent or translucent gel-type product. Typical characteristics of the zirconium silicate of the current invention include:
______________________________________ZIRCONIUM SILICATE SPECIFICATION______________________________________Density gm/cc 4.60Dielectric Constant 12.7Hardness, MOHS 7.5Melting Point 1538°-1677° C.Molecular Weight 183.1Reflectance, IR 60-75%Reflectance UV 80-85%Refractive Index 2.00Particle SizeSmaller than 0.4 microns No more than 25%Larger than 1.0 micron No more than 25%Within 0.4-1.0 microns At least 50%______________________________________
With specific regard to the fine-particle size synthetic, precipitated hydrated silicas proposed in this invention, it is important to incorporate at least 22% of such 22% material in dentifrice compositions, in the preferred range of to 50%, in combination with the type of zirconium silicate previously described, in order to achieve the exceptional cleansing effectiveness of the claimed invention. U.S. Pat. No. 3,538,230 describes oral compositions which contain synthetic, amorphous, precipitated hydrated silicas similar to those utilized in the dentifrice of this invention, but the preferred range of such material is described as 8% to 20%, and there is no mention of the use of zirconium silicate in combination with the synthetic precipitated silica.
For the purposes of this invention, the silicas employed are characterized as those produced in a liquid phase process and are described in the Cosmetic, Toiletry and Fragrance Association cosmetic ingredient dictionary as "hydrated silicas." They are prepared by reacting sodium silicate with sulfuric acid to produce silicon dioxide of an amorphous physical structure. Typical characteristics of the silicas employed in this invention include:
______________________________________HYDRATED SILICA SPECIFICATIONS______________________________________Total Volatiles 33.0-37.0%pH (5% in water) 8.0-9.5Wet Screen TestThru 325 Mesh 99.5% min.Heavy Metals 50 ppm. max.Particle Size 6-12 micronsSilicon Dioxide Content(dry basis) 99.0% min.______________________________________
Hydrated silicas of the type described herein are available commercially from the W. R. Grace & Company Davison Chemical Division and the J. M. Huber Company. A particularly valuable property of the hydrated silicas when used in viscous, semi-solid dentifrice compositions is that they have refractive indices of such magnitude that it is possible to compound them with a suitable liquid vehicle which has a refractive index value similar to that of the hydrated silica, to achieve transparent or translucent gel-type dentifrice. Such transparent or translucent products can be readily converted into opaque dentifrice pastes by the addition of titanium dioxide, zinc oxide, magnesium oxide or other water-insoluble, opacifying agents.
Another component which can be incorporated into the preferred cleansing dentifrices, if desired, is the complex molecule, alkali metal zinc citrate, the preparation, utilization and chemical properties of which have been described in U.S. Pat. No. 4,325,939.
In the preferred embodiment of this invention, the highest cleaning dentifrices utilize those components specifically claimed in this invention: the zirconium silicate of fine but controlled particle size, and the hydrated silica at a minimum level of 22%, each with specified chemical and physical characteristics as specified herein.
It is desirable, but not critical, to employ in the preferred embodiment of this invention, a water-soluble fluoride for the purpose of inhibiting dental caries. It is also desirable, but not critical, to employ in the preferred embodiment of this invention, the alkali metal salt of a zinc citrate complex, e.g. sodium zinc citrate or potassium zinc citrate, for its effects in suppressing oral malodor by the interaction and precipitation of volatile sulfur compounds (VSC's) by zinc ions, and its effects in inhibiting the deposition of dental calculus by preventing the crystallization of the hydroxyapatite of calcium phosphate.
In order to achieve cosmetically elegant dentifrice gels and pastes, it is advisable to incorporate into finished compositions, other agents customarily used for semi-solid dentifrice paste and gel products. Therefore, deionized or distilled water is incorporated at a level of 0-50%, and humectants such as glycerin, sorbitol, mannitol, polyethylene glycols and the like are incorporated at levels of 10-60%. Other soluble and insoluble ingredients may include a suitable foaming agent, such as sodium lauryl sulfate, sodium lauroyl sarcosinate or nonionic surfactants, a thickener such as one of the water-soluble synthetic cellulose derivatives, sodium alginate, carageenan, xanthan gum, carbomer 940, the copolymer of polyvinylpyrrolidone-maleic anhydride, or the like. Typical flavors such as peppermint, spearmint, cinnamaldehyde, wintergreen and the like, sweeteners such as saccharin, aspartame, cyclamates, and approved dyes may also be utilized in the current invention. Other ingredients which may be used for oral therapy needs include pyrophosphates to inhibit dental calculus formation, non-steroidal anti-inflammatory drugs, water-soluble copper salts as odor suppressants, urea or other alkalinizing agents to inhibit microbial acid production, sanguinaria or zinc salts as plaque suppressants and antibacterial agents including antibiotics, quaternary ammonium compounds (used with a nonionic foaming agent) and various phenolic compounds.
Typical compositions made in accordance with the teachings of this invention are offered below:
EXAMPLE I______________________________________Translucent Dentifrice Gel______________________________________Hydrated Silica 30.00%Zirconium Silicate 0.04%Water 16.71%Sorbitol 70% 40.00%Glycerin 10.00%Sodium Lauryl Sulfate 1.00%Flavor 1.00%Carageenan 1.00%Saccharin 0.25% 100.00%______________________________________
EXAMPLE II______________________________________Translucent Dentifrice Gel______________________________________Water 8.12%Sodium Zinc Citrate 1.00%Glycerin 10.00%Sorbitol 70% 45.00%Xanthan Gum 0.75%Sodium Fluoride 0.22%Sodium Saccharin 0.25%Hydrated Silica 25.00%Air-Borne Silica 7.00%Sodium Lauroyl Sarcosinate 1.00%Flavor 1.10%Dye Solution 0.50%Zirconium Silicate 0.06%______________________________________
______________________________________Opaque Toothpaste______________________________________Zirconium Silicate 0.05%Hydrated Silica 30.00%Glycerin 15.00%Sorbitol 70% 25.00%Hydroxyethylcellulose 1.00%Zinc Chloride 0.50%Citric Acid 2.00%Hexylresorcinol 0.05%Sodium Monofluorophosphate 0.76%Pluronic F68 1.50%Flavor 1.00%Titanium Dioxide 0.50%Sodium Saccharin 0.30%Water 22.34%______________________________________
Example I is a dentifrice gel with superior cleaning properties against dental stains. Example II represents a dentifrice gel with high cleaning which also contains sodium fluoride as a caries-inhibitory agent and sodium zinc citrate as an odor neutralizer. Example III is a toothpaste which contains zinc chloride as an inhibitor of dental plaque and calculus, hexyl resorcinol as an antibacterial agent and titanium dioxide as an opacifying agent.
Dentifrices of this invention have been evaluated for their cleaning performance against stained pellicle in accordance with the method described by Stookey, Burkhard and Schemehorn (J. Dent. Res. 61:1236-1239, Nov., 1982). In this procedure, bovine permanent incisors are cut to obtain labial enamel specimens approximately 10 mm2. The specimens are mounted in autopolymerizing methacrylate resins so that enamel is exposed. After cleaning and polishing, the enamel surfaces are etched with 1% hydrochloric acid, neutralized with sodium carbonate and re-etched with 1% phytic acid and rinsed. Specimens are then alternately and repeatedly immersed at 37° C. in a staining bath followed by air-drying. The staining solution contains instant coffee, instant tea, ferric chloride and gastric mucin dissolved in a trypticase soy broth inoculated with a Sarcinia Lutea turtox culture. After a substantial level of brown stain develops on test specimens, the now-pigmented specimens are dried and then mounted in a mechanical cross-brushing machine with a slurry of 25 g of test dentifrice and 40 ml of water, and brushed for 800 reciprocating double strokes. A slurry of a standard lot of calcium pyrophosphate serves as a standard against which all test dentifrices are compared. The efficiency of cleaning is determined by comparing stain levels before and after brushing, as follows: ##EQU1##
Good correlation has been demonstrated between results obtained by this method and in vivo clinical cleaning efficiency. When this method was used to compare the cleaning results of a large number of dentifrices with different abrasive systems, it was found that dentrifices prepared in accordance with the teachings of this invention produced the most effective levels of cleaning, as demonstrated in Table I.
TABLE I______________________________________CLEANING EFFICIENCY OF DENTIFRICES PREPAREDWITH DIFFERENT ABRASIVE SYSTEMS AGAINSTSTAINED PELLICLE CLEANINGDENTIFRICE AND ABRASIVE SYSTEM EFFICIENCY______________________________________Zirconium Silicate - Hydrated SilicaDentifrice (1) 165, 163, 160*Calcium Pyrophosphate Dentifrice (2) 141Hydrated Silica - Tetrasodium PyrophosphateDentifrice (2) 122Hydrated Silica Dentrifrice (2) 115Dicalcium Phosphate Anhydrous-DicalciumPhosphate Dihydrate Dentifrice (2) 115Reference Standard (3) 100Dicalcium Phosphate Dihydrate -Calcium Carbonate Dentifrice (2) 82Dicalcium Phosphate Dihydrate Dentifrice (2) 74Aluminum Hydroxide, Dicalcium PhosphateDihydrate Dentifrice (2) 62______________________________________ *Results of separate evaluations (1) Dentifrices prepared with abrasive systems in accordance with this invention (2) Leading commercial dentifrice (3) Calcium pyrophosphate slurry
Cleaning studies have also been done by an in vitro evaluation method in which tobacco tar stain serves as the pigmented substrate. The method of preparing stained bovine enamel with cigarette tar is similar to that described above, except that an alcoholic extract of cigarette tobacco is used instead of coffee and tea, and human saliva serves as the protein source rather than gastric mucin and bacteriological nutrient media. The method, which will be published, has been described as producing a typical tobacco tar stain which is very heavy and tenacious.
Dentifrices prepared in according with the teachings of this invention have been compared to a number of commercial dentifrice abrasive systems and have been found to exhibit superior cleaning as indicated in Table II.
TABLE II______________________________________CLEANING EFFICIENCY OF DENTIFRICES PREPAREDWITH DIFFERENT ABRASIVE SYSTEMS AGAINSTTOBACCO TAR-SALIVARY PROTEIN STAIN CLEANINGDENTIFRICE AND ABRASIVE SYSTEM EFFICIENCY______________________________________Zirconium Silicate-Hydrated SilicaDentifrice (1) 212, 213, 204*Hydrated Silica-Sodium PyrophosphateDentifrice (2) 159, 155*Hydrated Silica Dentifrice (2) 103, 117, 105*Zirconium Oxide-Hydrated SilicaDentifrice (2) 116Reference Standard (3) 100Dicalcium Phosphate Anydrous-DicalciumPhosphate Dihydrate Dentifrice (2) 98Aluminum Hydroxide, DicalciumPhosphate Dihydrate Dentifrice (2) 49Dicalcium Phosphate Dihydrate Dentifrice (2) 40Hydrated Silica, Calcium Carbonate Dentifrice (2) 45______________________________________ *Results of separate evaluations (1) Dentifrices prepared with abrasive systems in accordance with this invention (2) Leading commercial dentifrice (3) Calcium pyrophosphate slurry
It will be observed that the abrasive systems of this invention have levels of cleaning efficiency against in vitro coffee-tea-protein stained pellicle and in vitro protein-tobacco tar stains which are significantly better than abrasive systems currently used in existing commercial dentifrices. However, despite this superior performance, the levels of radioactive dentin abrasion of the dentifrices of this invention are in the range of 160-180, considerably lower than the level of 250 believed to be safe for use on human teeth.
Numerous variations in the composition of the dentifrice of this invention, within the scope of the appended claims, will occur to those skilled in the art in the light of the foregoing disclosure. The term "semi-solid" is used herein to embrace transparent, translucent and opaque gels and pastes. As has been suggested, in compounding suitable semi-solid dentifrice of this invention, innumerable combinations of foaming agents, humectants, thickeners, flavoring agents, dyes, therapeutic agents, odor suppressants, disinfectants, plaque suppressants, opacifiers and the like can be employed. Those set out specifically are merely illustrative.
|Patente citada||Fecha de presentación||Fecha de publicación||Solicitante||Título|
|US3450813 *||6 Oct 1967||17 Jun 1969||Indiana University Foundation||Dentifrice compositions comprising zirconium silicate of particular particle size|
|US3541017 *||4 Feb 1969||17 Nov 1970||Indiana University Foundation||Denture cleanser preparations comprising zirconium silicate and zirconium dioxide|
|US3647381 *||8 Abr 1968||7 Mar 1972||Reiter Gabriel||Dental-prophylaxis composition|
|US3892843 *||13 Ago 1973||1 Jul 1975||Howard R Alexander||Prophylactic dental compositions|
|US3904747 *||20 Jul 1972||9 Sep 1975||Colgate Palmolive Co||Dentifrice compositions|
|US3954961 *||30 Abr 1973||4 May 1976||Colgate-Palmolive Company||Dental polishing creams|
|US3957968 *||25 Mar 1975||18 May 1976||Colgate-Palmolive Company||Dentifrices containing flat flakes of alpha-alumina|
|US4075316 *||27 Feb 1976||21 Feb 1978||Colgate-Palmolive Company||Dentifrices|
|US4170634 *||17 Ene 1977||9 Oct 1979||Colgate Palmolive Company||Modified abrasive system for dentifrices|
|US4187288 *||4 Oct 1978||5 Feb 1980||Colgate Palmolive Company||Modified abrasive system for dentifrices|
|US4418053 *||4 Feb 1982||29 Nov 1983||Indiana University Foundation||Dental prophylaxis compositions and their use|
|Patente citante||Fecha de presentación||Fecha de publicación||Solicitante||Título|
|US5073368 *||15 May 1991||17 Dic 1991||Colgate-Palmolive Company||Sanguinaria mouthrinse having improved anti microbial activity and stability|
|US5165914 *||22 Oct 1991||24 Nov 1992||David G. Vlock||Oral compositions containing zinc lactate complexes|
|US5330748 *||19 May 1993||19 Jul 1994||Church & Dwight Co., Inc.||Dentifrices containing zinc oxide particles|
|US5385727 *||19 May 1993||31 Ene 1995||Church & Dwight Co., Inc.||Dentifrices containing zinc oxide particles and sodium bicarbonate|
|US5455024 *||26 Ene 1995||3 Oct 1995||Church & Dwight Co., Inc.||Dentifrices containing zinc oxide particles and sodium bicarbonate|
|US5976506 *||20 Sep 1995||2 Nov 1999||Chesebrough-Pond's Usa Co.||Oral compositions|
|US6086373 *||10 Nov 1998||11 Jul 2000||Schiff; Thomas||Method of cleaning teeth with a toothbrush with improved cleaning and abrasion efficiency|
|US6138314 *||24 Jul 1997||31 Oct 2000||Whitehill Oral Technologies, Inc.||Toothbrush with improved cleaning and abrasion efficiency|
|US6294155||8 Abr 1998||25 Sep 2001||W. R. Grace & Co. -Conn.||Abrasive silica compositions and dentifrice compositions prepared therefrom|
|US6861048 *||29 Jul 2002||1 Mar 2005||Warner-Lambert Company||Dentifrice compositions having reduced abrasivity|
|US9242125||21 Jul 2005||26 Ene 2016||Coglate-Palmolive Company||Oral composition containing non-aggregated zinc nanoparticles|
|US20070020201 *||21 Jul 2005||25 Ene 2007||Boyd Thomas J||Oral composition containing non-aggregated zinc nanoparticles|
|US20090010859 *||13 Jul 2005||8 Ene 2009||Philip Christopher Waterfield||Oral Composition|
|US20100189663 *||29 Dic 2009||29 Jul 2010||Gallis Karl W||Mouth rinse compositions including chemically modified silica or silicate materials for sustained delivery to tooth surfaces|
|US20110206749 *||25 Ago 2011||J.M. Huber Corporation||Silica materials for reducing oral malador|
|US20110236444 *||29 Sep 2011||Darsillo Michael S||Antimicrobial Silica Composites|
|EP0955836A1 *||24 Jul 1997||17 Nov 1999||Thomas Schiff||Toothbrush with improved cleaning and abrasion efficiency|
|WO1996009034A1 *||20 Sep 1995||28 Mar 1996||Unilever Nv||Oral compositions|
|WO1999020238A1 *||9 Oct 1998||29 Abr 1999||Warner Lambert Co||Metal ion-containing oral products with reduced astringency|
|WO2001045659A2 *||13 Dic 2000||28 Jun 2001||Duschek Nicole||Means for cleaning teeth with improved cleaning capacity|
|WO2006012988A1 *||13 Jul 2005||9 Feb 2006||Unilever Nv||Oral composition|
|WO2008122578A2 *||3 Abr 2008||16 Oct 2008||Glaxo Group Ltd||Oral care composition comprising particulate zinc oxide|
|Clasificación de EE.UU.||424/49, 424/52|
|Clasificación internacional||A61Q11/00, A61K8/25, A61K8/28|
|Clasificación cooperativa||A61K2800/412, A61K8/25, A61Q11/00, A61K8/28|
|Clasificación europea||A61K8/28, A61K8/25, A61Q11/00|
|28 Ene 1987||AS||Assignment|
Owner name: JEFFREY MARTIN, INC., 410 CLERMONT TERRACE, UNION,
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:ROSENTHAL, MURRAY W.;REEL/FRAME:004665/0062
Effective date: 19861217
|4 Sep 1990||CC||Certificate of correction|
|3 Mar 1993||FPAY||Fee payment|
Year of fee payment: 4
|15 Abr 1997||REMI||Maintenance fee reminder mailed|
|7 Sep 1997||LAPS||Lapse for failure to pay maintenance fees|
|18 Nov 1997||FP||Expired due to failure to pay maintenance fee|
Effective date: 19970910