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Número de publicaciónUS4871365 A
Tipo de publicaciónConcesión
Número de solicitudUS 06/929,577
Fecha de publicación3 Oct 1989
Fecha de presentación24 Dic 1986
Fecha de prioridad25 Abr 1985
TarifaPagadas
Número de publicación06929577, 929577, US 4871365 A, US 4871365A, US-A-4871365, US4871365 A, US4871365A
InventoresBarry L. Dumican
Cesionario originalAmerican Cyanamid Company
Exportar citaBiBTeX, EndNote, RefMan
Enlaces externos: USPTO, Cesión de USPTO, Espacenet
Polyglycolic acid, trimethylene carbonate linkager
US 4871365 A
Resumen
The invention involves the use of absorbable or absorbable/nonabsorbable components to fabricate textile vascular grafts of all sizes and specifically for repair of the peripheral vascular system and for coronary bypass use. The bioabsorbable component of the graft fosters increased tissue ingrowth into the graft as compared to conventional 100% nonabsorbable grafts. Increased tissue ingrowth leads to greater patency through formation of a vascularized neointima and less tendency to be aneurysmal through formation of a suitable adventitia. The absorbable component can be a variety of materials, including PGA, MAXOM™, etc., whereas the nonabsorbable component (to be used as the backbone) can be new materials, e.g. NOVAFIL®, or more conventional polymers, including polyester, polyamide or polypropylene. The vascular grafts further comprise an external support helically wrapped therearound and permanently attached to the outside surface.
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Reclamaciones(4)
We claim:
1. A tubular article useful in prosthetic surgery comprising a plurality of at least three different fibers, the first and second fibers manufactured from two different absorbable polymers, and the third fiber manufactured from a nonabsorbable polymer; and further comprising an external support helically wrapped about and permanently adhered to the outside surface of the article.
2. A tubular article useful in prosthetic surgery comprising a plurality of at least three different fibers, the first and second fibers manufactured from two different absorbable polymers, and the third fiber manufactured from a nonabsorbable polymer; and further comprising an external support, the external support having at least one fiber and means for permanently adhereing the at least one fiber of said support to the outside surface of the article, whereby said fiber of said support is helically wrapped about said outside surface and attached to said surface by the means for permanently adhering.
3. The article of claim 2 further comprising the external support having at least one fiber manufactured from an absorbable polymer.
4. The article of claim 3 wherein the absorbable polymer of the external support comprises at least one trimethylene carbonate linkage.
Descripción

This is a continuation of application Ser. No. 06/727,326, filed Apr. 25, 1985, now U.S. Pat. No. 4,652,264.

BACKGROUND OF THE INVENTION

This invention relates to a tubular article and specifically to a vascular graft containing an absorbable or absorbable/nonabsorbable biomaterial. The use of the vascular graft is for repair of the peripheral vascular system and for coronary bypass.

The absorbable material fosters increased tissue ingrowth into the graft as compared to nonabsorbable grafts. Increased tissue ingrowth leads to greater patency through formation of a vascularized neointima and less tendency to be aneurysmal through formation of a suitable adventitia.

The absorbable material can vary and includes polyglycolic acid (hereafter PGA), and a copolymer comprising glycolic acid ester and trimethylene carbonate linkages, e.g. the copolymer in the MAXON™ (American Cyanamid Company, Wayne, N.J. 07470 U.S.A.) suture.

The nonabsorbable material (which is used as the backbone) can be proprietary materials, e.g. a Hytrel™ (E.I. du Pont and Co., Wilmington, Delaware, U.S.A.) polymer, such as the polymer in the NOVAFIL™ (American Cyanamid Company, Wayne N.J.) suture. Alternatively, the nonabsorbable material can be more conventional polymers including a polyester, polyamide or polypropylene.

There has been a long felt need in the vascular graft art to develop a small diameter graft which will be generally acceptable to essentially all of the surgical community. The reasons for this long felt need are many and relate both to the biological requirements for a small diameter graft and to the limitations of the biomaterials generally used for these applications. Consequently, prior art small diameter vascular grafts, e.g. of 8 mm or less in diameter to even smaller diameter grafts, e.g. 4 mm or less in diameter, have not been universally accepted by the surgical community.

Various prior art vascular graft constructions and/or biomaterials have been used in an attempt to solve this long felt need. These prior art solutions have included but are not limited to, one or a combination of the following parameters:

1. Knitted or woven textile structures as vascular grafts for coronary artery bypass and the peripheral vascular system.

2. a. Vascular grafts having a biocomponent structure, i.e.one or more absorbable and nonabsorbable materials. b. The percentage of the absorbable material has varied from about 25 to less than 100%.

3. PGA as the absorbable component.

4. A polyester, e.g. Dacron™ (E.I. DuPont & Co., Del., U.S.A.), a polyamide, or a polypropylene as the nonabsorbable component.

None of these prior art solutions have been universally accepted by the surgical community for a small diameter vascular graft. Therefore, the surgical community continues to feel the need for an absorbable or absorbable/nonabsorbable small diameter vascular graft having a diameter of 8 mm. or less, and more specifically 4 mm. or less.

To solve this long felt need, critical questions about vascular graft construction and use have to be considered, including, but not limited to, the following:

a. What is the porosity of the vascular graft?

b. What is the compliance of the vascular graft?

c. What are the optimum textile and biological factors for manufacturing a graft, having a double tube configuration specifically, a nonabsorbable outer tube and an absorbable inner tube structure?

d. What are the optimum textile and biological factors for manufacturing a vascular graft having an external support structure?

SUMMARY OF THE INVENTION

A tubular article useful in prosthetic surgery has been invented. The article has a plurality of fibers manufactured from an absorbable polymer. The polymer comprises at least one trimethylene carbonate linkage. In one embodiment, the absorbable polymer is a copolymer. In another embodiment, the article is manufactured on a warp knitting machine. The absorbable polymer comprises more than about 50% by weight of the article. The remainder of the article, if any, comprises a plurality of fibers manufactured from a nonabsorbable polymer.

Another embodiment is an article manufactured on a weft knitting machine. The absorbable polymer comprises more than about 50% by weight of the article. The remainder of the article, if any, comprises a plurality of fibers manufactured from a nonabsorbable polymer.

Yet another embodiment is a woven article. The absorbable polymer in the warp and weft yarns comprises more than about 50% by weight of the article. The remainder, if any, comprises a plurality of fibers manufactured from a nonabsorbable polymer.

A generic embodiment of all of the above is a tubular article comprising a vascular graft.

A vascular graft has also been invented. The vascular graft has a plurality of fibers which are manufactured from an absorbable copolymer. The copolymer comprises up to about 50% by weight of trimethylene carbonate linkages. The copolymer in the MAXON™ (American Cyanamid Company, New Jersey, U.S.A.) suture contains a copolymer having trimethylene carbonate linkages. MAXON™, which is a poly(glycolide- co-trimethylene carbonate), has superior and unexpected properties when contrasted to other absorbable fibers. It is long-lasting. A portion of its original strength is retained out to 56 days; 50% of the strength remains through 28 days. The absorption rate of MAXON™ is approximately equal to PGA.

A MAXON™ fiber is more compliant than polyglycolic acid (herein PGA). A graft containing 75% MAXON™ in combination with Dacron™ graft has a compliance of 3.03. A similarly constructed PGA/Dacron™ graft has a compliance of 2.45. Compliance is measured as a percentage of diametral change per 100 mm Hg internal pressure change. Finally, the bending modulus of MAXON™ is approximately 325,000 p.s.i., indicating that MAXON™ is a much more flexible fiber than other absorbable fibers.

In one embodiment, the copolymer comprises about 50% by weight of glycolic acid ester linkages. In another embodiment, the copolymer consists of at least one glycolic or lactic acid ester linkage.

Another embodiment is a graft which is manufactured on a warp knitting machine. The absorbable polymer comprises more than about 50% by weight of the article. The remainder, if any, comprises a plurality of fibers manufactured from a nonabsorbable polymer. In a specific embodiment, the graft is manufactured on a Raschel knitting machine. In another specific embodiment, the plurality of nonabsorbable polymer fibers of the graft comprises about 20 to 35% by weight of the graft. In a more specific embodiment, the plurality of absorbable and nonabsorbable fibers are separately texturized by either a false twist or a knit/deknit process. In a most specific embodiment, the nonabsorbable polymer is Hytrel®. Another most specific embodiment is wherein the nonabsorbable polymer is polyethylene terephthalate.

Hytrel™ is a trademark of E.I. DuPont de Nemours & Co., Wilmington, Del. U.S.A. for a class of polymers having the following generic formula: ##STR1##

The values for a, x and y are known from the prior art, e.g. as disclosed in "Thermoplastic Copolyester Elastomers: New Polymers For Specific End-Use Applications", M. Brown, Rubber Industry 9 102-106 (1978), and the references (footnote numbers 1b, 1c, 1d, 2 and 3) cited therein; Encyclopedia of Polymer Science and Technology, Supplement, 2 485-510, see particularly pages 486 to 493, Interscience N.Y. 1977; and U.S. Pat. No. 4,314,561 issued Feb. 9, 1982. All of this prior art is incorporated herein by reference. A specific embodiment of Hytrel® which is useful in this invention is a grade of Hytrel® having a 72 durometer D hard.

The polymer in the Novafil™ (American Cyanamid Company, New Jersey, U.S.A.) suture contains Hytrel®. Novafil™, which is a polybutester, has superior and unexpected properties when contrasted to other nonabsorbable fibers. It is more flexible than other conventional-type graft fibers, e.g. Dacron™. Novafil™ has a bending modulus of approximately 230,000 p.s.i. Also, the compliance of a Novafil™ containing graft measures 4.20 in combination with MAXON™. A similar graft manufactured from Dacron™ and Maxon™ has a compliance of 3.03. Compliance is measured as a percentage of diametral change per 100 mm Hg internal pressure change.

Finally, a tubular article useful in prosthetic surgery and having a plurality of fibers manufactured from a nonabsorbable polymer has been invented. In a specific embodiment, the nonabsorbable polymer is Hytrel®.

A concentric knit relationship, wherein PGA comprises the inner tube, Maxon™ comprises the middle tube, and either Dacron™ or Novafil™ comprises the outer tube, has the following synergistic advantages:

(1) Dacron™ is known from the prior art to incite a thrombogenic reaction.

(2) Dacron™ or Novafil™ fibers can be shielded from blood by inner layers of PGA and MAXON™, thereby minimizing the tendency to thrombose and occlude the graft.

(3) As PGA and then MAXON™ degrade and are absorbed, the inner capsule becomes larger and, hence, has a higher probability of remaining patent in small diameter applications.

(4) Based upon animal studies, a PGA- and MAXON™- containing graft tends to have greater patency than a commercial graft material.

The concentric relationship can be a plurality of single tubes attached together by sewing, gluing, or merely held together by frictional contact between the layers.

The MAXON™ and/or PGA absorbable components of the graft become absorbed and are replaced by natural tissue. This leaves skeletal structure of nonabsorbable Dacron™ or Novafil™ fiber which is encapsulated in healthy collagenous tissue. The inside wall or neointima of the skeletal structure develops into an endothelial-like growth. The outside wall has been shown to be comprised of a matrix of mature, highly vascularized granulation tissue.

This invention also relates to a nonabsorbable vascular graft manufactured from a Hytrel™ polymer, such as the polymer in the Novafil™ suture.

This invention further relates to the method of texturizing and to the method of using the nonabsorbable vascular graft manufactured from the Hytrel™ polymer and/or the Novafil™ suture. For a description of manufacturing the Hytrel™ polymer, see e.g., U.S. Pat. Nos. 3,766,146; 3,763,109; 3,023,192; and Great Britain patent No. 1,458,341; for a description of manufacturing the Novafil™ suture, see, e.g., U.S. Pat. Nos. 4,224,946 and 4,314,561. All of these patents are incorporated herein by reference.

The materials can be constructed into vascular grafts in several ways: (1) as woven single tubes, (2) as warp or weft knit single tubes, (3) as double triple, etc. concentric tubes, and (4) as single woven or knit tubes that are externally supported. The materials can also be constructed from a fabric having a changing composition, e.g. a graded transition section in a fabric or a bicomponent filament. See U.S. Pat. No. 3,463,158 issued Aug. 26, 1969 entitled Polyglycolic Acid Prosthetic Devices, which is incorporated herein by reference. The graft structures can be either straight or bifurcated (branched) tubes.

A knitted tube can be manufactured on a Raschel knitting machine. The number of needles per inch can be about 25 to 35. The gauge (which is twice the number of needles per inch) can therefore be about 50 to 70. Prior art Raschel knitting machines are commercially available in a 56, 60 or 64 gauge.

DESCRIPTION OF THE PREFERRED EMBODIMENT

The following steps are followed when preparing knit vascular grafts starting from the appropriate yarns. The proper denier yarns for the specific construction have to be knit. If the denier to be used can only be obtained by using three or more ends, the yarn must be ply-twisted together. For example, if the construction is a 330-denier PGA and 100-denier textured Dacron™, and the only available PGA is 110-denier, it is necessary to twist three ends of 110-denier PGA and the one end of 100-denier Dacron™. Other variations can be used, depending on the type of construction called for. After ply-twisting onto a king spool, the twisted yarn is transferred to a model 50 cone, using a coning machine. It is preferred that any material that is not twisted and is to be used for knitting be transferred to a cone, or to a similar type package from which the yarn may easily be removed. The yarn is then set up on the knitting machine.

The knitting machine can be commercially available. It can be a floor-type self-contained unit, completely assembled, with exception of the yarn tension or stop-motion assembly. A direct V-belt drive from a fractional horsepower motor to the knitting head allows for a quiet knitting speed up to about 1100 r.p.m. A variable speed take-down assures minimum breakdowns and absolute quality stitch control. Operating speeds can vary depending on cylinder size and also the type of yarn or fibers used.

The proper density of the graft construction is obtained by changing the stitch cam and take-down settings. The stitch cam controls the length of the stitch, and the take-down controls the tension of the tubular fabric being knit.

After knitting, the graft material is scoured in xylene under ultrasonic agitation for two two-minute baths. The material is allowed to dry in a fume hood until no xylene odors can be detected. The graft material is then cut to appropriate lengths (e.g. 4 mm×60 mm; and/or 8 mm×80 mm) and then reversed.

Reversing involves turning the graft inside out to have a smooth inner surface, and a rougher outer surface to promote ingrowth. Any graft containing PGA is then post-treated on stainless steel mandrels at temperatures of about 115° C. to 150° C., under a vacuum approximately equal to 1 torr or lower. The post-treatment process seems to increase the tensile strength retention for the absorbable component, up to about 60 days after implant. A graft that does not contain PGA may not undergo the post-treatment process.

The ends of the graft may then be heated-sealed on a hot surface to prevent unravelling. During heat-sealing, the ends of the graft are melted only slightly.

Following scouring in xylene or another medically approved nonaqueous solvent and drying, the graft is then packaged in a polycarbonate folding container, which is then placed in a foil inner pouch. The graft is then sent through an absorbable device EtO-sterilization cycle. After sterilization, the graft is repacked in a 2-web TYVEK® (a spun bonded polyolefin manufactured by E. I. DuPont & Co., Wilmington, Del., U.S.A.)/Mylar™ (a polyethylene terephthalate also manufactured by E. I. DuPont & Co.) pouch, sealed and EtO-sterilized a second time.

A series of in vivo studies with woven vascular grafts in several configurations was completed. The following materials, although not exclusive, were included:

a) PGA/Dacron™ 80/20 low and high porosity, 4 and 6 mm in diameter

b) PGA/copolymer having glycolic acid ester, and trimethylene carbonate linkages, 4 mm

c) Woven non-crimped Dacron™, 4 and 6 mm; and

d) Gore-Tex (a Trademark of Wil-Gore & Associates, Inc.) 4, 8 and 10 mm.

The overall patency rate for PGA containing grafts was substantially higher than controls: 58% vs. 41%.

Bi- and tri-component vascular grafts made of biodegradable and non-degradable fibers have been studied in the beagle. Observations carried out from ˜30 days to ˜7 months showed that as the absorbable component left the graft structure, organized and oriented tissue invaded the graft approximating the location of the degraded material. The tissue ingrowth appeared to mobilize as a neointima with the lumenal surface covered by cells strongly resembling endothelium. The non-degradable component exhibited dispersed fibers within a matrix of mature, highly vascularized granulation tissue. This rich blood supply persisted for the period of maximum observation.

The graft structures were provided in two diameters: 4 and 8 mm ID. The former were studied as interpositional grafts in both carotids of the host; the latter as interpositional grafts in the thoracic aorta. The 4 mm grafts (40-60 mm in length) were examined at 1 and 2 months and showed high degrees of patency. The tissue reaction showed progressively increasing tissue incorporation although endothelization was absent at 1 month and only partially manifest at 2 months. The 8 mm grafts examined at ˜3-˜7 months were uniformly patent and showed uninterrupted complete endothelization of the graft lumen and complete replacement of the degradable material by the tissue elements noted above.

The present invention is illustrated by the following examples which can be useful in peripheral vascular surgery, as coronary artery bypasses or in general arterial or venous grafting.

EXAMPLE 1

This graft is a double-walled structure consisting of a 100% PGA woven inner tube and a 100% texturized knit Dacron™ velour outer tube. The structure was designed so that the inner wall, being PGA, would become absorbed and be replaced by a smooth, well-organized tissue at least partially consisting of endothelial cells. This inner wall would become the new intima. The outer wall, being constructed of porous nonabsorbable Dacron™ material, would allow tissue and capillary ingrowth and, at the same time, add support to the newly-grown neointima to prevent aneurysms. The Dacron™ outer wall material is a Sauvage Filamentous Velour® fabric supplied by U.S.C.I., a division of C. R. Bard Co., Inc., Billerica, Ma. USA. The inner wall fabric is a woven tube having a 1×1 plain weave construction using 5-ply, 46-denier, 21 filament (PGA) polyglycolic acid yarn in both the warp and filling direction.

The graft materials were scoured in xylene in an ultrasonic bath--2 baths of fresh xylene for 10 minutes each--to remove fiber spin finish.

The outer and inner tubes for the 4 mm I.D. grafts were cut to approximately 45 mm in length. The tubular woven PGA material was mounted on stainless steel rods, placed in a vacuum chamber and treated at 130° C. for 3 hours under a vacuum of less than 1 torr (a similar treatment was done for the 8 mm tubes, except they were cut to 80 mm length).

Next, the inner and outer tubes were stitched together by placing either 3 (4 mm I.D.) or 4 (8 mm I.D.) longitudinal rows of stitches between inner and outer wall. The double tube grafts were then packaged and EtO-sterilized prior to use as implants.

Following graft construction and sterilization, the 4 mm grafts were implanted in the left and right carotid arteries of thoroughbred beagle dogs. The 8 mm I.D. grafts were implanted in the thoracic aorta. The grafts were left in the animal for periods of up to 90 days, at which time the dogs were sacrificed, and the grafts were dissected and removed for subjective and histological examination.

Examination of the implant sites revealed absorption of the PGA fiber and replacement with a smooth, glistening endothelial-like neointima. The Dacron™ outer wall was ingrown with tissue and small blood vessels. There was little, if any, indication of aneurysmal dilation. Exclusive of technical error during implant, grafts were patent and blood flow, as determined by Doppler recording, was satisfactory.

EXAMPLE 2

A 3-ply yarn, consisting of 110-denier/50-filament PGA, 105-denier/25-filament MAXON™ (a copolymer having glycolic acid ester and trimethylene carbonate linkages, e.g. as described in U.S. Pat. No. 4,429,080 issued Jan. 31, 1984 and incorporated herein by reference), and 100-denier texturized Dacron™, was plied together at approximately 2 turns per inch of twist and knit into (a) 4 mm and (b) 8 mm inside diameter (I.D.) tubes. The knitting machine used was a Lamb ST3A circular weft knitting machine. The needle cylinder used had 25 needles per inch of circumference.

Following knitting, the tubular graft material was scoured, cut, post-treated, packaged and sterilized as described in Example 1.

The tricomponent structure, being comprised of both MAXON™ (glycolide-TMC) and polyglycolic acid yarns, after post-treatment attains a tighter, more pebbly velour-like appearance, due to the differential shrinkage between the two absorbable fibers in the presence of textured Dacron™.

The 4 mm and 8 mm grafts were implanted in beagle dogs, as described under Example 1.

Examination of the implant sites following sacrifice revealed partial to complete absorption of the bioabsorbable yarns, excellent patency, no noticeable aneurysmal formation and a uniform granular tissue forming the neointima and extending through the wall to the advential surface.

Table 1 is a summary of the in vivo animal data for the knit grafts constructed according to Example 2.

                                  TABLE 1__________________________________________________________________________SUMMARY OF ANIMAL DATA ON KNIT GRAFTS                             AneurysmalGraft       Number           Number                             Tendency                                    Number                                         NumberComposition Implanted             Implant Site                        Patent                             0123a                                    Occluded                                         Unsacrificed__________________________________________________________________________33/33/33 PGA/       6     Thoracic Aorta                        5    0041   --   1MAXON ™/Textured       4     Left Carotid Artery                        3    2010   1    --DACRON ®       6     Right Carotid Artery                        3    0031   2    1__________________________________________________________________________ a Rating: 0 = None 1 = Possible 2 = Slight 3 = Significant
EXAMPLE 3

A 4-ply yarn consisting of three ends of 105-denier MAXON™ (as described in the Background and in Example 2, above) and one end of 100-denier texturized Dacron™ was plied together at a twist level of approximately 2 turns/inch. The yarn was knit into 4 and 8 mm I.D. tubes on separate Lamb ST3A circular weft knitting machines, using 25-needle per inch knitting cylinders. These grafts had wall thicknesses of between 650 and 850 microns.

Following knitting, the graft material was scoured, cut to 45 and 80 mm lengths, heat-set at 110° C. for 1 to 3 minutes on stainless steel sizing rods, helically wrapped with 2-0 monofilament MAXON™ suture material as a means of external support, packaged and sterilized.

The external support material was attached to the outside surface of the vascular graft, using polymeric glycolide/trimethylene carbonate (TMC) dissolved in methylene chloride as an adhesive. Alternatively, poly-TMC dissolved in methylene chloride can be used as an adhesive. Table 2 is a summary of the in vivo animal data for the knit grafts constructed according to Example 3.

                                  TABLE 2__________________________________________________________________________SUMMARY OF ANIMAL DATA ON KNIT GRAFTS                             AneurysmalGraft       Number           Number                             Tendency                                    Number                                         NumberComposition Implanted             Implant Site                        Patent                             0123a                                    Occluded                                         Unsacrificed__________________________________________________________________________75/25 MAXON ™/       6     Thoracic Aorta                        6    2022   --   --Textured DACRON ®       3     Left Carotid Artery                        2    1010   1    --with External       4     Right Carotid Artery                        4    0112   --   --Support*__________________________________________________________________________ a Rating: 0 = None 1 = Possible 2 = Slight 3 = Significant *External support of monofilament MAXON ™ absorbable suture material.
EXAMPLE 4

A 4-ply yarn consisting of two ends of 46-denier PGA, one end of 62-denier PGA and one end of 100-denier texturized NOVAFIL® was assembled at approximately 2 turns per inch of twist. The texturized NOVAFIL® yarn was false-twist texturized, using the Helanca® (trademark of Heberlein Corp., Wattwil, Switzerland) process in order to provide a surface texture that would encourage maximum tissue ingrowth. The combined yarn was knit into 4 and 8 mm I.D. tubes similar to Example 3, except that the cylinder had a needle spacing of 33 needles per inch.

Following knitting, the graft materials were scoured, cut to 45 and 80 mm length tubes, post-treated on stainless steel rods under vacuum of 1 torr at 130° C. for 3 hours, cooled, helically wrapped with 3-0 MAXON™ monofilament suture material, attached to the surface of the graft using poly-TMC as an adhesive and, finally, packaged and sterilized.

EXAMPLE 5

In this warp knit example, 70-denier texturized Dacron™ was combined with 105-denier MAXON™ multifilament yarn on a 48-gauge Raschel knitting machine in the following construction:

______________________________________Front Bar    2/0     2/4     70-denier textured Dacron ™Back Bar 2/0     4/6     105-denier MAXON ™______________________________________
EXAMPLE 6

This construction is similar to Example 5, except that the stitch construction is reversed as follows:

______________________________________Front Bar    2/0     4/6     105-denier MAXON ™Back Bar 2/0     2/4     70-denier textured Dacron ™______________________________________

Examples 5 and 6, although formed on a 48-gauge Raschel machine can be made on a 56-, 60- or 64-gauge Raschel machine having 14 or more guide bars, positive feeds and stitch combs.

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Clasificaciones
Clasificación de EE.UU.623/23.71, 623/1.38, 623/1.33
Clasificación internacionalA61F2/06, C08G63/64, A61L27/18, A61L27/58, A61L27/50
Clasificación cooperativaA61L27/507, C08G63/64, D04B1/16, A61L27/18, A61F2/06, A61L27/58, D10B2509/06, D04B21/16
Clasificación europeaD04B21/16, D04B1/16, A61L27/18, C08G63/64, A61L27/50E, A61F2/06, A61L27/58
Eventos legales
FechaCódigoEventoDescripción
11 Abr 2003ASAssignment
Owner name: TYCO GROUP S.A.R.L., LUXEMBOURG
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:AMERICAN CYANAMID COMPANY;REEL/FRAME:013887/0951
Effective date: 19980227
Owner name: TYCO GROUP S.A.R.L. 6, AVENUE EMILE REUTER 2ND FLO
10 Abr 2003ASAssignment
Owner name: SHERWOOD SERVICES AG, SWITZERLAND
Free format text: CORRECTIVE ASSIGNMENT TO REMOVE PATENT NUMBER 5635254, PREVIOUSLY RECORDED AT REEL 010197 FRAME 0247;ASSIGNOR:TYCO GROUP S.A.R.L.;REEL/FRAME:013845/0514
Effective date: 19981016
Owner name: SHERWOOD SERVICES AG SCHWERTSTRASSE 9SCHAFFHAUSEN,
2 Abr 2001FPAYFee payment
Year of fee payment: 12
29 Jul 1999ASAssignment
Owner name: SHERWOOD SERVICES AG, SWITZERLAND
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:TYCO GROUP S.A.R.L.;REEL/FRAME:010197/0247
Effective date: 19981016
21 Mar 1997FPAYFee payment
Year of fee payment: 8
18 Mar 1993FPAYFee payment
Year of fee payment: 4