US5955503A - Compounds and compositions for delivering active agents - Google Patents
Compounds and compositions for delivering active agents Download PDFInfo
- Publication number
- US5955503A US5955503A US08/795,833 US79583397A US5955503A US 5955503 A US5955503 A US 5955503A US 79583397 A US79583397 A US 79583397A US 5955503 A US5955503 A US 5955503A
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- US
- United States
- Prior art keywords
- active agent
- biologically active
- composition
- dosage unit
- agent comprises
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/25—Growth hormone-releasing factor [GH-RF] (Somatoliberin)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH] (Somatotropin)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/48—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a saturated carbon skeleton containing rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/55—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an unsaturated carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
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- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being saturated and containing rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/64—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/76—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C235/78—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
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- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
Abstract
Description
Ar--Y--(R.sup.1).sub.n --OH XLVI
TABLE 1 ______________________________________ Oral Delivery of Interferon Carrier Dose Interferon Dose Mean Peak Serum Levels Carrier (mg/kg) (μg/kg) of Interferon (ng/mL) ______________________________________ XXVI 300 1000 6710 +/- 6658 XXXVII 160 1000 1025 +/- 276 XXVII 300 1000 3642 +/- 5895 XXXIV 400 1000 11341 +/- 8793 400 500 565 +/- 515 XXXIV (ID) 400 100 1775 +/- 1023 XXIX 600 100 3510 +/- 2171 I 300 1000 10972 +/- 3790 I (ID) 250 50 843 +/- 669 I 80 250 1369 +/- 1164 VI 300 1000 8213 +/- 3077 VI 600 1000 8428 +/- 5001 VI (ID) 1000 15469 +/- 6712 XXXVl 400 1000 43961 +/- 14910 XIV 800 1000 5518 +/- 2718 VII 600 1000 5568 +/- 3771 XXVII 300 1000 41966 +/- 19688 VIII 300 1000 1753 +/- 1529 XVIII 300 1000 19809 +/- 26107 XXX 300 1000 3910 +/- 3221 XL 300 1000 12661 +/- 10933 none 0 1000 688 +/- 173 ______________________________________
TABLE 2 ______________________________________ Oral Delivery of Calcitonin Carrier Dose Dose Drug Mean Peak Serum Levels Carrier (mg/kg) (μg/kg) of Calctonin ______________________________________ XXVI 10 300 -18 +/- 6 XXVIII 10 200 -14 +/- 6 I 10 200 -16 +/- 8 VII 10 200 -13 +/- 8 VI 10 200 -29 +/- 14 30 10 -13 +/- 4 10 30 -24 +/- 9 ______________________________________
TABLE 3 ______________________________________ Oral Delivery of rhGH Carrier Dose Dose Drug Mean Peak Serum Levels Carrier (mg/mL) (mg/mL) of rhGH (ng/mL) ______________________________________ XXVI 500 6 -127 +/- 40 XXVII 500 6 -64 +/- 7 VI 150 6 -33 +/- 13 VI (ID) 200 3 -103 +/- 85 VI (IC) 50 1.5 -98 +/- 19 II 400 6 55 +/- 36 XXX 400 6 66 +/- 37 XLV 400 6 28 +/- 9 IV 300 6 42 +/- 29 XLII 300 6 63 +/- 45 X 250 6 37 +/- 12 XXXII 200 6 44 +/- 36 none 0 6 <10 ______________________________________
TABLE 4 ______________________________________ Oral Delivery of Heparin Carrier Mean Peat APTT (sec) # Animals Responding ______________________________________ XXI 166 +/- 35 5/5 IX 102 +/- 33 34/35 VI 96 +/- 29 10/10 XLI 90 +/- 49 5/5 XXXV 73 +/- 16 4/4 VII 52 +/- 24 17/20 XV 67 +/- 30 4/5 XX 59 +/- 42 4/4 VII 58 +/- 28 14/15 XLII 45 +/- 14 5/5 XXXIII 44 +/- 28 12/20 XXVII 44 +/- 15 18/20 V 42 +/- 16 4/5 III 41 +/- 18 8/10 II 41 +/- 24 3/5 XXXIX 40 +/- 17 5/10 XIX 37 +/- 11 4/5 XXII 36 +/- 19 6/11 XXVIII 35 +/- 9 3/5 none 20.7 +/- 0.17 100/100 ______________________________________
Claims (27)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/795,833 US5955503A (en) | 1993-04-22 | 1997-02-06 | Compounds and compositions for delivering active agents |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/051,019 US5451410A (en) | 1993-04-22 | 1993-04-22 | Modified amino acids for encapsulating active agents |
US08/205,511 US5792451A (en) | 1994-03-02 | 1994-03-02 | Oral drug delivery compositions and methods |
US08/231,622 US5629020A (en) | 1994-04-22 | 1994-04-22 | Modified amino acids for drug delivery |
PCT/US1994/004560 WO1994023767A1 (en) | 1993-04-22 | 1994-04-22 | Oral drug delivery compositions and methods |
US08/335,148 US5643957A (en) | 1993-04-22 | 1994-10-25 | Compounds and compositions for delivering active agents |
US08/795,833 US5955503A (en) | 1993-04-22 | 1997-02-06 | Compounds and compositions for delivering active agents |
Related Parent Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/231,622 Continuation-In-Part US5629020A (en) | 1990-08-02 | 1994-04-22 | Modified amino acids for drug delivery |
US08/335,148 Division US5643957A (en) | 1993-04-22 | 1994-10-25 | Compounds and compositions for delivering active agents |
Publications (1)
Publication Number | Publication Date |
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US5955503A true US5955503A (en) | 1999-09-21 |
Family
ID=23310481
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
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US08/335,148 Expired - Lifetime US5643957A (en) | 1993-04-22 | 1994-10-25 | Compounds and compositions for delivering active agents |
US08/795,833 Expired - Lifetime US5955503A (en) | 1993-04-22 | 1997-02-06 | Compounds and compositions for delivering active agents |
US08/795,837 Expired - Fee Related US6100298A (en) | 1993-04-22 | 1997-02-06 | Compounds and compositions for delivering active agents |
Family Applications Before (1)
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6391303B1 (en) | 1996-11-18 | 2002-05-21 | Emisphere Technologies, Inc. | Methods and compositions for inducing oral tolerance in mammals |
US6440929B1 (en) | 1998-07-27 | 2002-08-27 | Emisphere Technologies, Inc. | Pulmonary delivery of active agents |
US20020127202A1 (en) * | 1996-03-29 | 2002-09-12 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US6525020B2 (en) * | 1997-02-07 | 2003-02-25 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US20030133953A1 (en) * | 1992-06-15 | 2003-07-17 | Emisphere Technologies, Inc. | Active agent transport systems |
US20030149296A1 (en) * | 2000-01-13 | 2003-08-07 | Boyd Maria Aurora P. | Compounds and compositions for delivering active agents |
WO2003072195A2 (en) | 2002-02-20 | 2003-09-04 | Eli Lilly And Company | Method for administering glp-1 molecules |
US6627228B1 (en) | 1999-01-08 | 2003-09-30 | Emisphere Technologies, Inc. | Polymeric delivery agents and delivery agents compounds |
US6642411B1 (en) | 1998-07-27 | 2003-11-04 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US6646162B2 (en) | 1999-02-26 | 2003-11-11 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US20030225300A1 (en) * | 2001-04-19 | 2003-12-04 | Emisphere Technologies Inc. | Compounds and compositions for delivering active agents |
US6663887B2 (en) | 1993-04-22 | 2003-12-16 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US20040048777A1 (en) * | 2000-06-29 | 2004-03-11 | Weidner John J | Compounds and compositions for delivering active agents |
US6818594B1 (en) | 1999-11-12 | 2004-11-16 | M-I L.L.C. | Method for the triggered release of polymer-degrading agents for oil field use |
US20050188038A1 (en) * | 2004-01-26 | 2005-08-25 | Nec Corporation | Method, device and computer readable medium for classifying electronic mails |
WO2005112937A1 (en) | 2004-05-19 | 2005-12-01 | Emisphere Technologies, Inc. | Acyclovir formulations |
US20050272638A1 (en) * | 1998-08-07 | 2005-12-08 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US6991798B1 (en) | 1998-08-07 | 2006-01-31 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
WO2006072070A2 (en) | 2004-12-29 | 2006-07-06 | Emisphere Technologies, Inc. | Pharmaceutical formulations of gallium salts |
US7084279B1 (en) | 1999-02-11 | 2006-08-01 | Emisphere Technologies Inc. | Oxadiazole compounds and compositions for delivering active agents |
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US20070293423A1 (en) * | 2003-08-20 | 2007-12-20 | Eli Lilly And Company | Compounds, Methods and Formulations for the Oral Delivery of a Glucagon-Like Peptide (Glp)-1 Compound or a Melanocortin-4 Receptor (Mc4) Agonist Peptide |
US20080200380A1 (en) * | 2005-01-12 | 2008-08-21 | Emisphere Technologies, Inc. | Compositions For Buccal Delivery Of Parathyroid Hormone |
US20080214448A1 (en) * | 2003-08-20 | 2008-09-04 | Emisphere Technologies Inc. | Compounds, Methods and Formulations for the Oral Delivery of a Glucagon-Like Peptide (Glp)-1 Compound or a Melanocortin-4 Receptor (Mc4) Agonist Peptide |
US20100016229A1 (en) * | 2003-12-19 | 2010-01-21 | Sarubbi Donald J | Oral GLP-1 Formulations |
US20100015088A1 (en) * | 2006-08-31 | 2010-01-21 | Emisphere Technologies Inc. | Compounds and compositions for delivering active agents |
US20100048454A1 (en) * | 2004-08-03 | 2010-02-25 | Emisphere Technologies, Inc. | Antidiabetic oral insulin-biguanide combination |
US20100239658A1 (en) * | 2006-06-28 | 2010-09-23 | Emisphere Technologies, Inc. | Gallium nitrate formulations |
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US11857553B2 (en) | 2016-02-11 | 2024-01-02 | Nutrition21, LLC | Chromium containing compositions for improving health and fitness |
Families Citing this family (116)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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US5693338A (en) | 1994-09-29 | 1997-12-02 | Emisphere Technologies, Inc. | Diketopiperazine-based delivery systems |
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US6099856A (en) | 1992-06-15 | 2000-08-08 | Emisphere Technologies, Inc. | Active agent transport systems |
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US6001347A (en) | 1995-03-31 | 1999-12-14 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5989539A (en) | 1995-03-31 | 1999-11-23 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5866536A (en) | 1995-03-31 | 1999-02-02 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5965121A (en) | 1995-03-31 | 1999-10-12 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
EP1792624A1 (en) * | 1995-03-31 | 2007-06-06 | Emisphere Technologies, Inc. | Modified amino acids and compositions comprising them for delivering active agents |
US5750147A (en) | 1995-06-07 | 1998-05-12 | Emisphere Technologies, Inc. | Method of solubilizing and encapsulating itraconazole |
GB2320248B (en) | 1995-09-11 | 1999-04-14 | Emisphere Tech Inc | Method for preparing omega-aminoalkanoic acid derivatives from cycloalkanones |
EP0904065A4 (en) | 1996-06-14 | 2000-06-14 | Emisphere Tech Inc | Microencapsulated fragrances and method for preparation |
US5804688A (en) | 1997-02-07 | 1998-09-08 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
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US6060513A (en) | 1997-02-07 | 2000-05-09 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
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US5863944A (en) * | 1997-04-30 | 1999-01-26 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5962710A (en) | 1997-05-09 | 1999-10-05 | Emisphere Technologies, Inc. | Method of preparing salicyloylamino acids |
US7018654B2 (en) * | 1999-03-05 | 2006-03-28 | New River Pharmaceuticals Inc. | Pharmaceutical composition containing an active agent in an amino acid copolymer structure |
US6716452B1 (en) | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
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US7129274B1 (en) | 1999-11-05 | 2006-10-31 | Emisphere Technologies Inc. | Phenoxy carboxylic acid compounds and compositions for delivering active agents |
AU2274201A (en) * | 1999-12-16 | 2001-06-25 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
WO2003057650A2 (en) | 2002-01-09 | 2003-07-17 | Emisphere Technologies, Inc. | Polymorphs of sodium 4-[(4-chloro-2-hydroxybenzoyl)amino]butanoate |
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EP2308479A3 (en) | 2001-03-01 | 2012-10-24 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US20060014697A1 (en) * | 2001-08-22 | 2006-01-19 | Travis Mickle | Pharmaceutical compositions for prevention of overdose or abuse |
US7169752B2 (en) * | 2003-09-30 | 2007-01-30 | New River Pharmaceuticals Inc. | Compounds and compositions for prevention of overdose of oxycodone |
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WO2003045331A2 (en) | 2001-11-29 | 2003-06-05 | Emisphere Technologies, Inc. | Formulations for oral administration of cromolyn sodium |
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CA2525168A1 (en) * | 2003-05-14 | 2004-12-02 | Emisphere Technologies, Inc. | Compositions for delivering peptide yy and pyy agonists |
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KR101306384B1 (en) | 2004-08-23 | 2013-09-09 | 맨카인드 코포레이션 | Diketopiperazine salts, diketomorpholine salts or diketodioxane salts for drug delivery |
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US8975227B2 (en) | 2005-07-15 | 2015-03-10 | Emisphere Technologies, Inc. | Intraoral dosage forms of glucagon |
AU2006280953B2 (en) * | 2005-08-19 | 2013-01-24 | Emisphere Technologies, Inc. | Cyclopropyl compounds and compositions for delivering active agents |
JP5465878B2 (en) | 2005-09-14 | 2014-04-09 | マンカインド コーポレイション | Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents |
CN104383546B (en) | 2006-02-22 | 2021-03-02 | 曼金德公司 | Method for improving the pharmaceutical properties of microparticles comprising diketopiperazines and an active agent |
US8703821B2 (en) * | 2006-04-18 | 2014-04-22 | Emisphere Technologies Inc. | Dialkyl ether delivery agents |
CA2659682C (en) | 2006-06-26 | 2010-12-21 | The Procter & Gamble Company | Prolyl hydroxylase inhibitors and methods of use |
AU2007265373B2 (en) | 2006-06-29 | 2013-02-21 | Atnx Spv, Llc | Biaryl compositions and methods for modulating a kinase cascade |
US9873667B2 (en) | 2006-07-27 | 2018-01-23 | Emisphere Technologies Inc. | Arylsulfanyl compounds and compositions for delivering active agents |
JP5564255B2 (en) | 2006-08-18 | 2014-07-30 | エミスフェアー・テクノロジーズ・インク | Synthesis of propylphenoxy ether and use as a delivery agent |
US7939529B2 (en) | 2007-05-17 | 2011-05-10 | Kinex Pharmaceuticals, Llc | Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof |
TWI457336B (en) | 2006-12-28 | 2014-10-21 | Kinex Pharmaceuticals Llc | Composition and methods for modulating a kinase cascade |
US7935697B2 (en) | 2006-12-28 | 2011-05-03 | Kinex Pharmaceuticals, Llc | Compositions for modulating a kinase cascade and methods of use thereof |
AU2008210434C8 (en) | 2007-01-31 | 2014-03-27 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
MX340993B (en) | 2007-02-08 | 2016-08-02 | Emisphere Tech Inc * | Phenylalkylcarboxylic acid delivery agents. |
CA2678575C (en) * | 2007-02-16 | 2013-10-08 | Emisphere Technologies, Inc. | Compounds having a cyclic moiety and compositions for delivering active agents |
CA2680737C (en) * | 2007-03-21 | 2015-12-15 | Emisphere Technologies, Inc. | Allyloxy and alkyloxy benzoic acid delivery agents |
BRPI0809366B8 (en) | 2007-03-28 | 2021-05-25 | Harvard College | substantially alpha-helical polypeptide, method for manufacturing same, amino acid and pharmaceutical composition |
US8124605B2 (en) | 2007-07-06 | 2012-02-28 | Kinex Pharmaceuticals, Llc | Compositions and methods for modulating a kinase cascade |
CN104689432B (en) | 2008-06-13 | 2018-07-06 | 曼金德公司 | Diskus and the system for drug conveying |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
JP5479465B2 (en) | 2008-06-20 | 2014-04-23 | マンカインド コーポレイション | Interactive device and method for profiling inhalation efforts in real time |
TWI494123B (en) | 2008-08-11 | 2015-08-01 | Mannkind Corp | Use of ultrarapid acting insulin |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
PL2405963T3 (en) | 2009-03-11 | 2014-04-30 | Mannkind Corp | Apparatus, system and method for measuring resistance of an inhaler |
EP2440184B1 (en) | 2009-06-12 | 2023-04-05 | MannKind Corporation | Diketopiperazine microparticles with defined specific surface areas |
DE102009046115A1 (en) * | 2009-10-28 | 2011-09-08 | Bayer Schering Pharma Aktiengesellschaft | Substituted 3-phenylpropanoic acids and their use |
WO2011056889A1 (en) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | An apparatus and method for simulating inhalation efforts |
US20130150323A1 (en) * | 2010-02-04 | 2013-06-13 | Urigen Pharmaceuticals, Inc | Use of oral heparin preparations to treat urinary tract diseases and conditions |
WO2011129936A2 (en) | 2010-04-16 | 2011-10-20 | Kinex Pharmaceuticals, Llc | Compositions and methods for the prevention and treatment of cancer |
RU2571331C1 (en) | 2010-06-21 | 2015-12-20 | Маннкайнд Корпорейшн | Systems and methods for dry powder drug delivery |
US9714238B2 (en) * | 2010-07-02 | 2017-07-25 | Allergan, Inc. | Therapeutic agents for ocular hypertension |
WO2012003145A2 (en) * | 2010-07-02 | 2012-01-05 | Allergan, Inc. | Therapeutic agents for ocular hypertension |
US8859723B2 (en) | 2010-08-13 | 2014-10-14 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
AU2011340721A1 (en) | 2010-12-07 | 2013-06-20 | Bayer Intellectual Property Gmbh | Substituted 1-benzylcycloalkylcarboxlic acids and use thereof |
WO2012130193A1 (en) | 2011-03-31 | 2012-10-04 | Zentiva, K.S. | Non-covalent soluble complexes of teriparatide with polysaccharides and a dosage form of teriparatide for oral administration |
DK2694402T3 (en) | 2011-04-01 | 2017-07-03 | Mannkind Corp | BLISTER PACKAGE FOR PHARMACEUTICAL CYLINDER AMPULS |
DE102011007272A1 (en) | 2011-04-13 | 2012-10-18 | Bayer Pharma Aktiengesellschaft | Branched 3-phenylpropionic acid derivatives and their use |
WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
CN108929375A (en) | 2011-10-18 | 2018-12-04 | 爱勒让治疗公司 | Peptidomimetic macrocyclic compound |
AU2012328885B2 (en) | 2011-10-24 | 2017-08-31 | Mannkind Corporation | Methods and compositions for treating pain |
US8927500B2 (en) | 2012-02-15 | 2015-01-06 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
US8987414B2 (en) | 2012-02-15 | 2015-03-24 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
DE102012208530A1 (en) | 2012-05-22 | 2013-11-28 | Bayer Pharma AG | Substituted piperidinoacetamides and their use |
AU2013289957B2 (en) | 2012-07-12 | 2017-02-23 | Mannkind Corporation | Dry powder drug delivery systems and methods |
EP2888224B1 (en) | 2012-08-23 | 2017-11-15 | Emisphere Technologies, Inc. | Phenoxy alkyl diethanolamine and diisopropanolamine compounds for delivering active agents |
US9926273B2 (en) | 2012-08-30 | 2018-03-27 | Athenex, Inc. | Composition and methods for modulating a kinase cascade |
WO2014066856A1 (en) | 2012-10-26 | 2014-05-01 | Mannkind Corporation | Inhalable influenza vaccine compositions and methods |
JP6526563B2 (en) | 2012-11-01 | 2019-06-05 | エイルロン セラピューティクス,インコーポレイテッド | Disubstituted amino acids and methods for their preparation and use |
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JP2016530930A (en) | 2013-08-05 | 2016-10-06 | マンカインド コーポレイション | Ventilation device and method |
WO2015148905A1 (en) | 2014-03-28 | 2015-10-01 | Mannkind Corporation | Use of ultrarapid acting insulin |
SG10201902594QA (en) | 2014-09-24 | 2019-04-29 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and uses thereof |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
MX2017011834A (en) | 2015-03-20 | 2018-04-11 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and uses thereof. |
BR112018011177A2 (en) | 2015-12-03 | 2018-11-21 | Biosight Ltd | cytarabine conjugates for cancer therapy |
IL259569B2 (en) | 2015-12-03 | 2024-03-01 | Biosight Ltd | Salts of cytarabine-amino acids conjugates |
US10905667B2 (en) | 2018-07-24 | 2021-02-02 | Bayer Pharma Aktiengesellschaft | Orally administrable modified-release pharmaceutical dosage form |
Citations (149)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2671451A (en) * | 1952-06-16 | 1954-03-09 | Stephen J Bolger | Remedial pill |
US2862918A (en) * | 1956-03-12 | 1958-12-02 | Glidden Co | Acylated, isolated, partially-hydrolyzed, soya protein and process |
US2868740A (en) * | 1954-03-25 | 1959-01-13 | Swift & Co | Method of copolymerizing acrylic or methacrylic acid with proteinaceous material and product obtained |
USRE24899E (en) * | 1953-06-30 | 1960-11-29 | Oil-containrab | |
US2971916A (en) * | 1957-01-30 | 1961-02-14 | Ncr Co | Microscopic capsules containing magnetizable material |
US3016308A (en) * | 1957-08-06 | 1962-01-09 | Moore Business Forms Inc | Recording paper coated with microscopic capsules of coloring material, capsules and method of making |
US3052655A (en) * | 1958-08-01 | 1962-09-04 | Sidney W Fox | Thermal polymerization of amino acid mixtures containing aspartic acid or a thermal precursor of aspartic acid |
US3057344A (en) * | 1957-05-21 | 1962-10-09 | Abella Carlos Alberto | Capsule for the study of the digestive tract and method of using the same |
US3076790A (en) * | 1958-08-01 | 1963-02-05 | Sidney W Fox | Method of making copolymers of amino acids containing glutamic acid |
GB929401A (en) | 1958-12-22 | 1963-06-19 | Upjohn Co | Encapsulated emulsions and processes for their preparation |
FR1351358A (en) | 1958-12-22 | 1964-02-07 | Ncr Co | Process for forming impermeable coatings for particulate matter by liquid phase separation |
US3170802A (en) * | 1960-12-14 | 1965-02-23 | Zh Noda Sangyo Kagaku Kenkyush | Method for treatment of soybean proteins |
US3190837A (en) * | 1958-12-31 | 1965-06-22 | Ncr Co | Making individual capsules by dual deposition |
FR1468601A (en) | 1958-12-22 | 1967-02-10 | Ncr Co | Process for forming protective coatings for solid and liquid particles |
GB1075952A (en) | 1962-12-31 | 1967-07-19 | Gelatine And Glue Res Ass | Microscopic capsules and methods of making them |
US3474777A (en) * | 1966-02-10 | 1969-10-28 | Amp Inc | Method of administering therapeutic agents |
US3491093A (en) * | 1967-11-29 | 1970-01-20 | Endo Lab | Derivatives of 5 aminomethyl-4,5,6,7-tetrahydro-4-oxoindoles |
US3565559A (en) * | 1968-03-11 | 1971-02-23 | Sumitomo Chemical Co | Process for making microcapsules |
US3567650A (en) * | 1969-02-14 | 1971-03-02 | Ncr Co | Method of making microscopic capsules |
US3574832A (en) * | 1968-05-29 | 1971-04-13 | American Cyanamid Co | Therapeutic heparin-surfactant compositions |
US3576758A (en) * | 1966-10-17 | 1971-04-27 | Ncr Co | Treatment of polypeptide-containing hydrophilic polymeric capsule wall material with uranium and vanadium compounds |
GB1236885A (en) | 1968-09-28 | 1971-06-23 | Fuji Photo Film Co Ltd | Method of making multi-wall capsules |
US3687926A (en) * | 1967-10-21 | 1972-08-29 | Takeda Chemical Industries Ltd | Surfactin |
US3725113A (en) * | 1970-12-17 | 1973-04-03 | Research Corp | Blood compatible microencapsulated detoxicants and method for making |
US3748277A (en) * | 1965-10-14 | 1973-07-24 | Ncr Co | Process of forming minute capsules |
US3794561A (en) * | 1971-09-30 | 1974-02-26 | Sasaki T | Biologically active peptide and method of preparing the same |
US3795739A (en) * | 1972-02-14 | 1974-03-05 | Hoffmann La Roche | Treatment of parkinson disease |
US3816404A (en) * | 1971-12-08 | 1974-06-11 | Texaco Inc | Preparation of caprolactam |
US3822348A (en) * | 1970-12-28 | 1974-07-02 | Toyo Jozo Kk | Hormone-like substance having serum calcium reducing property |
US3849550A (en) * | 1971-04-21 | 1974-11-19 | Yeda Res & Dev | Therapeutic copolymer |
DE2424169A1 (en) | 1973-05-17 | 1974-12-05 | Little Inc A | IMPLANT BODY AND METHOD OF ITS MANUFACTURING |
DE2343037A1 (en) | 1973-08-25 | 1975-03-06 | Hoechst Ag | MEDICINAL PRODUCTS WITH ANTIDEPRESSIVE EFFECT |
US3933873A (en) * | 1971-12-08 | 1976-01-20 | Texaco Inc. | Preparation of omega-aminoalkanoic acids |
US3937668A (en) * | 1970-07-15 | 1976-02-10 | Ilse Zolle | Method for incorporating substances into protein microspheres |
US3939253A (en) * | 1973-11-02 | 1976-02-17 | Interx Research Corporation | Novel, transient pro-drug forms of l-dopa useful in the treatment of parkinson's disease |
US3956172A (en) * | 1972-07-19 | 1976-05-11 | Fuji Photo Film Co., Ltd. | Process for hardening microcapsules containing hydrophobic oil droplets |
US3962416A (en) * | 1971-01-25 | 1976-06-08 | Sol Katzen | Preserved nutrients and products |
US3976773A (en) * | 1974-03-19 | 1976-08-24 | John Wyeth & Brother Limited | Piperazine diones |
US4035507A (en) * | 1975-04-17 | 1977-07-12 | Interx Research Corporation | Novel, transient pro-drug forms of L-DOPA to treat Parkinson's disease |
US4048268A (en) * | 1975-02-19 | 1977-09-13 | Eli Lilly And Company | Stabilization method |
US4061466A (en) * | 1974-10-16 | 1977-12-06 | Ingvar Gosta Holger Sjoholm | Biologically active composition and the use thereof |
US4117801A (en) * | 1976-06-10 | 1978-10-03 | Eastman Kodak Company | Apparatus for spray coating discrete particles |
US4147767A (en) * | 1975-10-09 | 1979-04-03 | Minnesota Mining And Manufacturing Company | Albumin medicament carrier system |
US4183849A (en) * | 1975-01-15 | 1980-01-15 | Nordisk Insulinlaboratorium | Therapeutic insulin preparation and a process for the production of a stable insulin preparation with protracted effect |
US4199561A (en) * | 1979-02-26 | 1980-04-22 | The Dow Chemical Company | Coated nutrients and medicaments for veterinary use |
US4217370A (en) * | 1977-08-25 | 1980-08-12 | Blue Wing Corporation | Lipid-containing feed supplements and foodstuffs |
US4239635A (en) * | 1979-06-11 | 1980-12-16 | Cincinnati Milacron Inc. | Novel diamide and lubricants containing same |
US4239754A (en) * | 1976-10-23 | 1980-12-16 | Choay, S.A. | Liposomes containing heparin and a process for obtaining them |
US4272506A (en) * | 1979-08-31 | 1981-06-09 | Syva Company | Purification of reagents by disulfide immobilization |
US4289759A (en) * | 1980-06-23 | 1981-09-15 | Ortho Pharmaceutical Corporation | Immunoregulatory diketopiperazine compounds |
US4345588A (en) * | 1979-04-23 | 1982-08-24 | Northwestern University | Method of delivering a therapeutic agent to a target capillary bed |
US4348384A (en) * | 1980-10-17 | 1982-09-07 | Dainippon Pharmaceutical Co., Ltd. | Pharmaceutical composition for oral administration containing coagulation factor VIII or IX |
US4351337A (en) * | 1973-05-17 | 1982-09-28 | Arthur D. Little, Inc. | Biodegradable, implantable drug delivery device, and process for preparing and using the same |
US4352883A (en) * | 1979-03-28 | 1982-10-05 | Damon Corporation | Encapsulation of biological material |
US4357259A (en) * | 1977-08-01 | 1982-11-02 | Northwestern University | Method of incorporating water-soluble heat-sensitive therapeutic agents in albumin microspheres |
EP0068314A1 (en) | 1981-06-19 | 1983-01-05 | Ciba-Geigy Ag | Treatment of arthritic complaints |
US4388304A (en) * | 1980-01-18 | 1983-06-14 | Richter Gedeon Vegyeszeti Gyar Rt | Angiotensin-II analogues with antagonizing effects, containing an ester group in position 8, and a process for the preparation thereof |
US4393192A (en) * | 1982-12-21 | 1983-07-12 | The Standard Oil Company | Crystalline copolymers prepared from N,N'-terephthaloyldi-beta-alanine and a glycol |
US4402968A (en) * | 1980-06-06 | 1983-09-06 | Hoffmann-La Roche Inc. | Antifungal benzofuranyl imidazole compounds |
US4402856A (en) * | 1980-04-26 | 1983-09-06 | Bayer Aktiengesellschaft | Microcapsules with a defined opening temperature, a process for their production and their use |
US4405598A (en) * | 1976-01-30 | 1983-09-20 | Fisons, Limited | Composition for treating asthma |
US4442090A (en) * | 1980-11-09 | 1984-04-10 | Kyoto Yakuhin Kogyo Kabushiki Kaisha | Absorption-promoting compounds, compositions thereof with pharmaceuticals and/or bases for rectal administration and method of use |
US4446138A (en) * | 1982-02-10 | 1984-05-01 | Pack Howard M | Method and composition for reducing weight |
US4450150A (en) * | 1973-05-17 | 1984-05-22 | Arthur D. Little, Inc. | Biodegradable, implantable drug delivery depots, and method for preparing and using the same |
US4460563A (en) * | 1980-04-09 | 1984-07-17 | Eurand S.P.A. | Process for preparing microcapsules in a liquid vehicle |
US4462991A (en) * | 1980-03-07 | 1984-07-31 | Interx Research Corp. | Method of increasing oral absorption of polar bioactive agents |
US4462839A (en) * | 1983-06-16 | 1984-07-31 | Fmc Corporation | Enteric coating for pharmaceutical dosage forms |
US4473620A (en) * | 1982-12-23 | 1984-09-25 | Eastman Kodak Company | Encapsulated butylated hydroxyanisole |
US4483807A (en) * | 1981-01-27 | 1984-11-20 | Japan Atomic Energy Research Institute | Process for producing a slow release composite |
US4492684A (en) * | 1983-06-08 | 1985-01-08 | Connaught Laboratories Limited | Slow release injectable insulin composition |
US4518433A (en) * | 1982-11-08 | 1985-05-21 | Fmc Corporation | Enteric coating for pharmaceutical dosage forms |
GB2095994B (en) | 1981-03-06 | 1985-10-02 | Toyo Jozo Kk | Preparations having excellent absorption property |
US4590265A (en) * | 1984-02-17 | 1986-05-20 | Eastman Kodak Company | Carboxylated cellulose ester and manufacture thereof |
US4608278A (en) * | 1983-06-22 | 1986-08-26 | The Ohio State University Research Foundation | Small particule formation and encapsulation |
US4613500A (en) * | 1983-03-09 | 1986-09-23 | Teijin Limited | Powdery pharmaceutical composition for nasal administration |
US4647455A (en) * | 1982-02-22 | 1987-03-03 | Queen's University At Kingston | Process for extracting atrial natriuretic factor |
FR2565102B1 (en) | 1984-06-05 | 1987-03-20 | Paris Sud Universite | BIODEGRADABLE MICROCAPSULES BASED ON SERUMALBUMIN, THEIR PREPARATION AND THEIR APPLICATION TO THE IN SITU RELEASE OF MEDICUMENTS |
US4671954A (en) * | 1983-12-13 | 1987-06-09 | University Of Florida | Microspheres for incorporation of therapeutic substances and methods of preparation thereof |
US4673566A (en) * | 1983-06-01 | 1987-06-16 | Connaught Laboratories Limited | Microencapsulation of living tissue and cells |
US4690786A (en) * | 1983-12-12 | 1987-09-01 | Nitto Electric Industrial Co., Ltd. | Process for producing a microcapsule containing a liquid active material |
US4692284A (en) * | 1986-04-30 | 1987-09-08 | Damon Biotech, Inc. | Method and apparatus for forming droplets and microcapsules |
US4703042A (en) * | 1984-05-21 | 1987-10-27 | Bodor Nicholas S | Orally active heparin salts containing multivalent cationic units |
US4708952A (en) * | 1985-02-06 | 1987-11-24 | Aida Salatinjants | Method of treatment of the infectious and viral diseases by one time interference |
US4745161A (en) * | 1985-04-10 | 1988-05-17 | Ceskoslovenska Akademie Ved | Soluble and biodegradable polyamino acid activated for bonding of biologically active compound |
US4753804A (en) * | 1984-12-12 | 1988-06-28 | Boehringer Biochemica S.P.A. | Granular dietetic product based on amino acids and process for their preparation |
US4757066A (en) * | 1984-10-15 | 1988-07-12 | Sankyo Company Limited | Composition containing a penem or carbapenem antibiotic and the use of the same |
US4757007A (en) * | 1984-02-22 | 1988-07-12 | The Nisshin Oil Mills, Ltd. | Process for preparing hydrolyzed products of soy protein |
US4757024A (en) * | 1985-05-31 | 1988-07-12 | Biostar Medical Products, Inc. | Immune complex detection method and article using immunologically non-specific immunoglobulins |
US4766012A (en) * | 1985-08-29 | 1988-08-23 | Farmaceutici Formenti S.P.A. | Microencapsulation of a medicament |
US4774320A (en) * | 1986-02-07 | 1988-09-27 | Sclavo S.P.A. | Synthetic peptide with human interleukin 1 activity |
US4789734A (en) * | 1985-08-06 | 1988-12-06 | La Jolla Cancer Research Foundation | Vitronectin specific cell receptor derived from mammalian mesenchymal tissue |
US4837381A (en) * | 1986-08-11 | 1989-06-06 | American Cyanamid Company | Compositions for parenteral administration and their use |
US4844904A (en) * | 1985-11-22 | 1989-07-04 | Takeda Chemical Industries, Ltd. | Liposome composition |
US4873087A (en) * | 1982-01-14 | 1989-10-10 | Toyo Jozo Company, Ltd. | Suppository preparation having excellent absorption property |
US4886663A (en) * | 1983-01-03 | 1989-12-12 | Scripps Clinic And Research Foundation | Synthetic heat-stable enterotoxin polypeptide of Escherichia coli and multimers thereof |
US4897444A (en) * | 1985-05-31 | 1990-01-30 | The Research Foundation Of The State University Of New York | Immobilized fluorogenic substrates for enzymes; and processes for their preparation |
US4900730A (en) * | 1981-01-14 | 1990-02-13 | Toyo Jozo Co., Ltd. | Preparation which promotes the absorption of peptides |
US4908233A (en) * | 1985-05-08 | 1990-03-13 | Lion Corporation | Production of microcapsules by simple coacervation |
US4919939A (en) * | 1986-04-29 | 1990-04-24 | Pharmetrix Corporation | Periodontal disease treatment system |
US4925673A (en) * | 1986-08-18 | 1990-05-15 | Clinical Technologies Associates, Inc. | Delivery systems for pharmacological agents encapsulated with proteinoids |
US4963364A (en) * | 1989-04-10 | 1990-10-16 | Fox Sidney W | Microencapsulated antitumor agent |
US4976968A (en) * | 1989-02-24 | 1990-12-11 | Clinical Technologies Associates, Inc. | Anhydrous delivery systems for pharmacological agents |
US4983402A (en) * | 1989-02-24 | 1991-01-08 | Clinical Technologies Associates, Inc. | Orally administerable ANF |
US4996292A (en) * | 1989-06-30 | 1991-02-26 | Fox Sidney W | Self-sealing artificial skin comprising copoly-alpha-amino acid |
US5019400A (en) * | 1989-05-01 | 1991-05-28 | Enzytech, Inc. | Very low temperature casting of controlled release microspheres |
US5023374A (en) * | 1986-09-23 | 1991-06-11 | Firma Willi Moller | Dicarboxylic acid diamides, process for their preparation, ion selective members and test means containing them as well as lithium complexes of the dicarboxylic acid amides |
US5039481A (en) * | 1988-12-16 | 1991-08-13 | Clean Air, Inc. | Aliphatic polycarboxylic acids as air purification compositions |
US5041291A (en) * | 1987-01-03 | 1991-08-20 | Hoechst Aktiengesellschaft | Biodegradable poly(hydroxyalkyl)amino dicarboxylic acid) derivatives, a process for their preparation, and the use thereof for depot formulations with controlled deivery of active ingredient |
US5055300A (en) * | 1988-06-17 | 1991-10-08 | Basic Bio Systems, Inc. | Time release protein |
EP0452161A1 (en) | 1990-02-12 | 1991-10-16 | Elf Sanofi | Cosmetic composition containing amino acids copolymers, useful as hydrating agent |
US5066487A (en) | 1988-09-14 | 1991-11-19 | Rhone-Poulenc Chimie | Antisudoral composition comprising dibasic aluminium salts of acylated amino acids |
US5067961A (en) | 1988-02-18 | 1991-11-26 | Autogenesis Technologies, Inc. | Non-biodegradable two phase corneal implant and method for preparing same |
US5069936A (en) | 1987-06-25 | 1991-12-03 | Yen Richard C K | Manufacturing protein microspheres |
EP0105804B1 (en) | 1982-09-30 | 1991-12-11 | The University Of Rochester | Human monoclonal antibodies against bacterial toxins |
US5077278A (en) | 1987-01-23 | 1991-12-31 | Pfizer Inc. | Non-natural demethylavermectins compositions and method of use |
US5100918A (en) | 1989-05-25 | 1992-03-31 | Sterling Drug, Inc. | Prevention or treatment of sunburn using the S(+) isomer of ibuprofen |
US5100669A (en) | 1988-02-24 | 1992-03-31 | Biomaterials Universe, Inc. | Polylactic acid type microspheres containing physiologically active substance and process for preparing the same |
US5122367A (en) | 1989-03-31 | 1992-06-16 | Massachusetts Institute Of Technology | Polyanhydride bioerodible controlled release implants for administration of stabilized growth hormone |
US5126147A (en) | 1990-02-08 | 1992-06-30 | Biosearch, Inc. | Sustained release dosage form |
US5137892A (en) | 1990-12-12 | 1992-08-11 | Abbott Laboratories | Quinoline, naphthyridine and pyridobenzoxazine derivatives |
EP0365183B1 (en) | 1988-10-10 | 1993-02-10 | Smith Kline & French Laboratories Limited | Biologically active compounds |
US5186947A (en) | 1990-10-20 | 1993-02-16 | Dr. Wolman Gmbh | Wood preservative based on polymeric nitrogen compounds and metal-fixing acids |
US5206384A (en) | 1990-09-04 | 1993-04-27 | Zaidan Hojin Biseibutsu Kagaku Kai | Actinonin derivatives and pharmaceutically acceptable salts thereof |
US5216124A (en) | 1989-12-15 | 1993-06-01 | G. D. Searle & Co. | Substituted cyclic tetrapeptides |
EP0418642B1 (en) | 1989-09-11 | 1993-06-09 | Teikoku Seiyaku Kabushiki Kaisha | High-absorbable transvaginal preparation containing biologically active peptides |
US5244653A (en) | 1991-05-01 | 1993-09-14 | Isp Chemicals Inc. | Glycine anhydride dimethylol as a biocide and preservative |
US5250236A (en) | 1991-08-05 | 1993-10-05 | Gasco Maria R | Method for producing solid lipid microspheres having a narrow size distribution |
EP0366277B1 (en) | 1988-09-29 | 1993-12-15 | Patralan Limited | Pharmaceutical formulations |
US5271934A (en) | 1990-10-22 | 1993-12-21 | Revlon Consumer Products Corporation | Encapsulated antiperspirant salts and deodorant/antiperspirants |
US5271961A (en) | 1989-11-06 | 1993-12-21 | Alkermes Controlled Therapeutics, Inc. | Method for producing protein microspheres |
US5278148A (en) | 1989-03-28 | 1994-01-11 | Hoffmann-La Roche Inc. | Amino acid derivatives useful for treating high blood pressure |
EP0467389A3 (en) | 1990-07-19 | 1994-02-02 | Univ Kentucky Res Found | |
US5310535A (en) | 1992-04-24 | 1994-05-10 | The Dow Chemical Company | Carboxamide modified polyamine chelators and radioactive complexes thereof for conjugation to antibodies |
US5328992A (en) | 1987-07-23 | 1994-07-12 | Ciba-Geigy Corp. | Metal complexes of polyethylene glycol carbamate derivatives of desferrioxamine B |
US5352461A (en) | 1992-03-11 | 1994-10-04 | Pharmaceutical Discovery Corporation | Self assembling diketopiperazine drug delivery system |
EP0459795B1 (en) | 1990-06-01 | 1994-10-26 | Kirin-Amgen, Inc. | Oral dosage form of biologically active proteins |
US5384133A (en) | 1986-08-11 | 1995-01-24 | Innovata Biomed Limited | Pharmaceutical formulations comprising microcapsules |
US5389379A (en) | 1992-02-18 | 1995-02-14 | Akzo N.V. | Process for the preparation of biologically active material containing polymeric microcapsules |
US5389377A (en) | 1989-12-22 | 1995-02-14 | Molecular Bioquest, Inc. | Solid care therapeutic compositions and methods for making same |
US5401516A (en) | 1992-12-21 | 1995-03-28 | Emisphere Technologies, Inc. | Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof |
US5418010A (en) | 1990-10-05 | 1995-05-23 | Griffith Laboratories Worldwide, Inc. | Microencapsulation process |
US5443841A (en) | 1992-06-15 | 1995-08-22 | Emisphere Technologies, Inc. | Proteinoid microspheres and methods for preparation and use thereof |
US5447728A (en) | 1992-06-15 | 1995-09-05 | Emisphere Technologies, Inc. | Desferrioxamine oral delivery system |
US5451410A (en) | 1993-04-22 | 1995-09-19 | Emisphere Technologies, Inc. | Modified amino acids for encapsulating active agents |
EP0448057B1 (en) | 1990-03-19 | 1996-05-08 | Bristol-Myers Squibb Company | Monoclonal antibody reactive with a novel HLA determinant on MHC class I molecules and method for activating lymphocytes |
US5536813A (en) | 1993-04-23 | 1996-07-16 | Rhone-Poulenc Chimie | Detersive polyanhydroaspartic acids and biodegradable hydrolysates thereof |
US5541155A (en) | 1994-04-22 | 1996-07-30 | Emisphere Technologies, Inc. | Acids and acid salts and their use in delivery systems |
US5578323A (en) | 1992-06-15 | 1996-11-26 | Emisphere Technologies, Inc. | Proteinoid carriers and methods for preparation and use thereof |
US5705529A (en) | 1992-06-30 | 1998-01-06 | Gyogyszerkutato Intezet Kft | N-benzoyl amino acid derivatives pharmaceutical compositions containing them and process for preparing same |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2828206A (en) * | 1954-02-24 | 1958-03-25 | Roseuberg Adolf | Stabilized fat-soluble vitamins and methods of making same |
DK140801B (en) | 1975-01-15 | 1979-11-19 | Nordisk Insulinlab | Process for the preparation of a stable long-acting insulin preparation. |
GB2092136B (en) * | 1981-01-17 | 1985-06-05 | Mitsui Toatsu Chemicals | Production of n-substituted amide compounds |
US4689182A (en) * | 1985-12-20 | 1987-08-25 | Warner-Lambert Company | Benzoic acid and benzoic acid ester derivatives having anti-inflammatory and analgesic activity |
LU86258A1 (en) * | 1986-01-21 | 1987-09-03 | Rech Dermatologiques C I R D S | BENZAMIDO AROMATIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE IN HUMAN OR VETERINARY MEDICINE AND IN COSMETICS |
JPH0725725B2 (en) * | 1987-07-23 | 1995-03-22 | 保土谷化学工業株式会社 | Benzamide derivative |
US4895725A (en) * | 1987-08-24 | 1990-01-23 | Clinical Technologies Associates, Inc. | Microencapsulation of fish oil |
US5629020A (en) * | 1994-04-22 | 1997-05-13 | Emisphere Technologies, Inc. | Modified amino acids for drug delivery |
EP1025840B1 (en) * | 1993-04-22 | 2005-06-29 | Emisphere Technologies, Inc. | Oral drug compositions |
-
1994
- 1994-10-25 US US08/335,148 patent/US5643957A/en not_active Expired - Lifetime
-
1995
- 1995-10-16 WO PCT/US1995/013527 patent/WO1996012473A1/en active IP Right Grant
- 1995-10-16 CA CA002203033A patent/CA2203033C/en not_active Expired - Lifetime
- 1995-10-16 ES ES95937558T patent/ES2207655T3/en not_active Expired - Lifetime
- 1995-10-16 DE DE69531741T patent/DE69531741T2/en not_active Expired - Lifetime
- 1995-10-16 AT AT95937558T patent/ATE249422T1/en not_active IP Right Cessation
- 1995-10-16 AU AU39633/95A patent/AU711887B2/en not_active Ceased
- 1995-10-16 BR BR9510168A patent/BR9510168A/en not_active Application Discontinuation
- 1995-10-16 PL PL95319833A patent/PL319833A1/en unknown
- 1995-10-16 EP EP95937558A patent/EP0783299B1/en not_active Expired - Lifetime
- 1995-10-16 HU HU9800903A patent/HUT77759A/en unknown
- 1995-10-16 CZ CZ971229A patent/CZ122997A3/en unknown
- 1995-10-16 JP JP51406296A patent/JP4223547B2/en not_active Expired - Lifetime
-
1997
- 1997-02-06 US US08/795,833 patent/US5955503A/en not_active Expired - Lifetime
- 1997-02-06 US US08/795,837 patent/US6100298A/en not_active Expired - Fee Related
- 1997-04-24 NO NO971889A patent/NO971889L/en unknown
- 1997-04-25 FI FI971776A patent/FI971776A0/en unknown
Patent Citations (159)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2671451A (en) * | 1952-06-16 | 1954-03-09 | Stephen J Bolger | Remedial pill |
USRE24899E (en) * | 1953-06-30 | 1960-11-29 | Oil-containrab | |
US2868740A (en) * | 1954-03-25 | 1959-01-13 | Swift & Co | Method of copolymerizing acrylic or methacrylic acid with proteinaceous material and product obtained |
US2862918A (en) * | 1956-03-12 | 1958-12-02 | Glidden Co | Acylated, isolated, partially-hydrolyzed, soya protein and process |
US2971916A (en) * | 1957-01-30 | 1961-02-14 | Ncr Co | Microscopic capsules containing magnetizable material |
US3057344A (en) * | 1957-05-21 | 1962-10-09 | Abella Carlos Alberto | Capsule for the study of the digestive tract and method of using the same |
US3016308A (en) * | 1957-08-06 | 1962-01-09 | Moore Business Forms Inc | Recording paper coated with microscopic capsules of coloring material, capsules and method of making |
US3076790A (en) * | 1958-08-01 | 1963-02-05 | Sidney W Fox | Method of making copolymers of amino acids containing glutamic acid |
US3052655A (en) * | 1958-08-01 | 1962-09-04 | Sidney W Fox | Thermal polymerization of amino acid mixtures containing aspartic acid or a thermal precursor of aspartic acid |
GB929401A (en) | 1958-12-22 | 1963-06-19 | Upjohn Co | Encapsulated emulsions and processes for their preparation |
FR1351358A (en) | 1958-12-22 | 1964-02-07 | Ncr Co | Process for forming impermeable coatings for particulate matter by liquid phase separation |
FR1468601A (en) | 1958-12-22 | 1967-02-10 | Ncr Co | Process for forming protective coatings for solid and liquid particles |
US3190837A (en) * | 1958-12-31 | 1965-06-22 | Ncr Co | Making individual capsules by dual deposition |
US3170802A (en) * | 1960-12-14 | 1965-02-23 | Zh Noda Sangyo Kagaku Kenkyush | Method for treatment of soybean proteins |
GB1075952A (en) | 1962-12-31 | 1967-07-19 | Gelatine And Glue Res Ass | Microscopic capsules and methods of making them |
US3748277A (en) * | 1965-10-14 | 1973-07-24 | Ncr Co | Process of forming minute capsules |
US3474777A (en) * | 1966-02-10 | 1969-10-28 | Amp Inc | Method of administering therapeutic agents |
US3576758A (en) * | 1966-10-17 | 1971-04-27 | Ncr Co | Treatment of polypeptide-containing hydrophilic polymeric capsule wall material with uranium and vanadium compounds |
US3687926A (en) * | 1967-10-21 | 1972-08-29 | Takeda Chemical Industries Ltd | Surfactin |
US3491093A (en) * | 1967-11-29 | 1970-01-20 | Endo Lab | Derivatives of 5 aminomethyl-4,5,6,7-tetrahydro-4-oxoindoles |
US3565559A (en) * | 1968-03-11 | 1971-02-23 | Sumitomo Chemical Co | Process for making microcapsules |
US3574832A (en) * | 1968-05-29 | 1971-04-13 | American Cyanamid Co | Therapeutic heparin-surfactant compositions |
GB1236885A (en) | 1968-09-28 | 1971-06-23 | Fuji Photo Film Co Ltd | Method of making multi-wall capsules |
US3567650A (en) * | 1969-02-14 | 1971-03-02 | Ncr Co | Method of making microscopic capsules |
US3937668A (en) * | 1970-07-15 | 1976-02-10 | Ilse Zolle | Method for incorporating substances into protein microspheres |
US3725113A (en) * | 1970-12-17 | 1973-04-03 | Research Corp | Blood compatible microencapsulated detoxicants and method for making |
US3822348A (en) * | 1970-12-28 | 1974-07-02 | Toyo Jozo Kk | Hormone-like substance having serum calcium reducing property |
US3962416A (en) * | 1971-01-25 | 1976-06-08 | Sol Katzen | Preserved nutrients and products |
US3849550A (en) * | 1971-04-21 | 1974-11-19 | Yeda Res & Dev | Therapeutic copolymer |
FR2133926B1 (en) | 1971-04-21 | 1975-12-26 | Yeda Research Develop Co | |
US3794561A (en) * | 1971-09-30 | 1974-02-26 | Sasaki T | Biologically active peptide and method of preparing the same |
US3816404A (en) * | 1971-12-08 | 1974-06-11 | Texaco Inc | Preparation of caprolactam |
US3933873A (en) * | 1971-12-08 | 1976-01-20 | Texaco Inc. | Preparation of omega-aminoalkanoic acids |
US3795739A (en) * | 1972-02-14 | 1974-03-05 | Hoffmann La Roche | Treatment of parkinson disease |
US3956172A (en) * | 1972-07-19 | 1976-05-11 | Fuji Photo Film Co., Ltd. | Process for hardening microcapsules containing hydrophobic oil droplets |
DE2424169A1 (en) | 1973-05-17 | 1974-12-05 | Little Inc A | IMPLANT BODY AND METHOD OF ITS MANUFACTURING |
US4450150A (en) * | 1973-05-17 | 1984-05-22 | Arthur D. Little, Inc. | Biodegradable, implantable drug delivery depots, and method for preparing and using the same |
US4351337A (en) * | 1973-05-17 | 1982-09-28 | Arthur D. Little, Inc. | Biodegradable, implantable drug delivery device, and process for preparing and using the same |
DE2343037A1 (en) | 1973-08-25 | 1975-03-06 | Hoechst Ag | MEDICINAL PRODUCTS WITH ANTIDEPRESSIVE EFFECT |
US3939253A (en) * | 1973-11-02 | 1976-02-17 | Interx Research Corporation | Novel, transient pro-drug forms of l-dopa useful in the treatment of parkinson's disease |
US3976773A (en) * | 1974-03-19 | 1976-08-24 | John Wyeth & Brother Limited | Piperazine diones |
US4061466A (en) * | 1974-10-16 | 1977-12-06 | Ingvar Gosta Holger Sjoholm | Biologically active composition and the use thereof |
US4183849A (en) * | 1975-01-15 | 1980-01-15 | Nordisk Insulinlaboratorium | Therapeutic insulin preparation and a process for the production of a stable insulin preparation with protracted effect |
US4048268A (en) * | 1975-02-19 | 1977-09-13 | Eli Lilly And Company | Stabilization method |
US4035507A (en) * | 1975-04-17 | 1977-07-12 | Interx Research Corporation | Novel, transient pro-drug forms of L-DOPA to treat Parkinson's disease |
US4147767A (en) * | 1975-10-09 | 1979-04-03 | Minnesota Mining And Manufacturing Company | Albumin medicament carrier system |
CA1077842A (en) | 1975-10-09 | 1980-05-20 | Minnesota Mining And Manufacturing Company | Albumin medicament carrier system |
GB1567763A (en) | 1975-10-09 | 1980-05-21 | Minnesota Mining & Mfg | Albumin medicament carrier system |
FR2326934B1 (en) | 1975-10-09 | 1979-07-20 | Minnesota Mining & Mfg | |
US4405598A (en) * | 1976-01-30 | 1983-09-20 | Fisons, Limited | Composition for treating asthma |
US4117801A (en) * | 1976-06-10 | 1978-10-03 | Eastman Kodak Company | Apparatus for spray coating discrete particles |
US4239754A (en) * | 1976-10-23 | 1980-12-16 | Choay, S.A. | Liposomes containing heparin and a process for obtaining them |
US4357259A (en) * | 1977-08-01 | 1982-11-02 | Northwestern University | Method of incorporating water-soluble heat-sensitive therapeutic agents in albumin microspheres |
US4217370A (en) * | 1977-08-25 | 1980-08-12 | Blue Wing Corporation | Lipid-containing feed supplements and foodstuffs |
US4199561A (en) * | 1979-02-26 | 1980-04-22 | The Dow Chemical Company | Coated nutrients and medicaments for veterinary use |
US4352883A (en) * | 1979-03-28 | 1982-10-05 | Damon Corporation | Encapsulation of biological material |
US4345588A (en) * | 1979-04-23 | 1982-08-24 | Northwestern University | Method of delivering a therapeutic agent to a target capillary bed |
US4239635A (en) * | 1979-06-11 | 1980-12-16 | Cincinnati Milacron Inc. | Novel diamide and lubricants containing same |
US4272506A (en) * | 1979-08-31 | 1981-06-09 | Syva Company | Purification of reagents by disulfide immobilization |
US4388304A (en) * | 1980-01-18 | 1983-06-14 | Richter Gedeon Vegyeszeti Gyar Rt | Angiotensin-II analogues with antagonizing effects, containing an ester group in position 8, and a process for the preparation thereof |
US4462991A (en) * | 1980-03-07 | 1984-07-31 | Interx Research Corp. | Method of increasing oral absorption of polar bioactive agents |
US4460563A (en) * | 1980-04-09 | 1984-07-17 | Eurand S.P.A. | Process for preparing microcapsules in a liquid vehicle |
US4402856A (en) * | 1980-04-26 | 1983-09-06 | Bayer Aktiengesellschaft | Microcapsules with a defined opening temperature, a process for their production and their use |
US4402968A (en) * | 1980-06-06 | 1983-09-06 | Hoffmann-La Roche Inc. | Antifungal benzofuranyl imidazole compounds |
US4289759A (en) * | 1980-06-23 | 1981-09-15 | Ortho Pharmaceutical Corporation | Immunoregulatory diketopiperazine compounds |
US4348384A (en) * | 1980-10-17 | 1982-09-07 | Dainippon Pharmaceutical Co., Ltd. | Pharmaceutical composition for oral administration containing coagulation factor VIII or IX |
US4442090A (en) * | 1980-11-09 | 1984-04-10 | Kyoto Yakuhin Kogyo Kabushiki Kaisha | Absorption-promoting compounds, compositions thereof with pharmaceuticals and/or bases for rectal administration and method of use |
US4900730A (en) * | 1981-01-14 | 1990-02-13 | Toyo Jozo Co., Ltd. | Preparation which promotes the absorption of peptides |
DE3202255C2 (en) | 1981-01-27 | 1987-07-09 | Japan Atomic Energy Research Institute, Tokio/Tokyo, Jp | |
US4483807A (en) * | 1981-01-27 | 1984-11-20 | Japan Atomic Energy Research Institute | Process for producing a slow release composite |
GB2095994B (en) | 1981-03-06 | 1985-10-02 | Toyo Jozo Kk | Preparations having excellent absorption property |
EP0068314A1 (en) | 1981-06-19 | 1983-01-05 | Ciba-Geigy Ag | Treatment of arthritic complaints |
US4873087A (en) * | 1982-01-14 | 1989-10-10 | Toyo Jozo Company, Ltd. | Suppository preparation having excellent absorption property |
US4446138A (en) * | 1982-02-10 | 1984-05-01 | Pack Howard M | Method and composition for reducing weight |
US4647455A (en) * | 1982-02-22 | 1987-03-03 | Queen's University At Kingston | Process for extracting atrial natriuretic factor |
EP0105804B1 (en) | 1982-09-30 | 1991-12-11 | The University Of Rochester | Human monoclonal antibodies against bacterial toxins |
US4518433A (en) * | 1982-11-08 | 1985-05-21 | Fmc Corporation | Enteric coating for pharmaceutical dosage forms |
US4393192A (en) * | 1982-12-21 | 1983-07-12 | The Standard Oil Company | Crystalline copolymers prepared from N,N'-terephthaloyldi-beta-alanine and a glycol |
US4473620A (en) * | 1982-12-23 | 1984-09-25 | Eastman Kodak Company | Encapsulated butylated hydroxyanisole |
US4886663A (en) * | 1983-01-03 | 1989-12-12 | Scripps Clinic And Research Foundation | Synthetic heat-stable enterotoxin polypeptide of Escherichia coli and multimers thereof |
US4613500A (en) * | 1983-03-09 | 1986-09-23 | Teijin Limited | Powdery pharmaceutical composition for nasal administration |
US4673566A (en) * | 1983-06-01 | 1987-06-16 | Connaught Laboratories Limited | Microencapsulation of living tissue and cells |
US4492684A (en) * | 1983-06-08 | 1985-01-08 | Connaught Laboratories Limited | Slow release injectable insulin composition |
US4462839A (en) * | 1983-06-16 | 1984-07-31 | Fmc Corporation | Enteric coating for pharmaceutical dosage forms |
US4608278A (en) * | 1983-06-22 | 1986-08-26 | The Ohio State University Research Foundation | Small particule formation and encapsulation |
US4690786A (en) * | 1983-12-12 | 1987-09-01 | Nitto Electric Industrial Co., Ltd. | Process for producing a microcapsule containing a liquid active material |
US4671954A (en) * | 1983-12-13 | 1987-06-09 | University Of Florida | Microspheres for incorporation of therapeutic substances and methods of preparation thereof |
US4590265B1 (en) * | 1984-02-17 | 1989-08-15 | ||
US4590265A (en) * | 1984-02-17 | 1986-05-20 | Eastman Kodak Company | Carboxylated cellulose ester and manufacture thereof |
US4757007A (en) * | 1984-02-22 | 1988-07-12 | The Nisshin Oil Mills, Ltd. | Process for preparing hydrolyzed products of soy protein |
US4703042A (en) * | 1984-05-21 | 1987-10-27 | Bodor Nicholas S | Orally active heparin salts containing multivalent cationic units |
US4666641A (en) * | 1984-06-05 | 1987-05-19 | Universite Paris-Sud (Paris Xi) | Preparation of biodegradable microcapsules based on serum albumin |
FR2565102B1 (en) | 1984-06-05 | 1987-03-20 | Paris Sud Universite | BIODEGRADABLE MICROCAPSULES BASED ON SERUMALBUMIN, THEIR PREPARATION AND THEIR APPLICATION TO THE IN SITU RELEASE OF MEDICUMENTS |
US4757066A (en) * | 1984-10-15 | 1988-07-12 | Sankyo Company Limited | Composition containing a penem or carbapenem antibiotic and the use of the same |
US4753804A (en) * | 1984-12-12 | 1988-06-28 | Boehringer Biochemica S.P.A. | Granular dietetic product based on amino acids and process for their preparation |
US4708952A (en) * | 1985-02-06 | 1987-11-24 | Aida Salatinjants | Method of treatment of the infectious and viral diseases by one time interference |
US4745161A (en) * | 1985-04-10 | 1988-05-17 | Ceskoslovenska Akademie Ved | Soluble and biodegradable polyamino acid activated for bonding of biologically active compound |
US4908233A (en) * | 1985-05-08 | 1990-03-13 | Lion Corporation | Production of microcapsules by simple coacervation |
US4897444A (en) * | 1985-05-31 | 1990-01-30 | The Research Foundation Of The State University Of New York | Immobilized fluorogenic substrates for enzymes; and processes for their preparation |
US4757024A (en) * | 1985-05-31 | 1988-07-12 | Biostar Medical Products, Inc. | Immune complex detection method and article using immunologically non-specific immunoglobulins |
US4789734A (en) * | 1985-08-06 | 1988-12-06 | La Jolla Cancer Research Foundation | Vitronectin specific cell receptor derived from mammalian mesenchymal tissue |
US4766012A (en) * | 1985-08-29 | 1988-08-23 | Farmaceutici Formenti S.P.A. | Microencapsulation of a medicament |
US4844904A (en) * | 1985-11-22 | 1989-07-04 | Takeda Chemical Industries, Ltd. | Liposome composition |
US4774320A (en) * | 1986-02-07 | 1988-09-27 | Sclavo S.P.A. | Synthetic peptide with human interleukin 1 activity |
US4919939A (en) * | 1986-04-29 | 1990-04-24 | Pharmetrix Corporation | Periodontal disease treatment system |
US4692284A (en) * | 1986-04-30 | 1987-09-08 | Damon Biotech, Inc. | Method and apparatus for forming droplets and microcapsules |
US4837381A (en) * | 1986-08-11 | 1989-06-06 | American Cyanamid Company | Compositions for parenteral administration and their use |
US5384133A (en) | 1986-08-11 | 1995-01-24 | Innovata Biomed Limited | Pharmaceutical formulations comprising microcapsules |
US4925673A (en) * | 1986-08-18 | 1990-05-15 | Clinical Technologies Associates, Inc. | Delivery systems for pharmacological agents encapsulated with proteinoids |
US5023374A (en) * | 1986-09-23 | 1991-06-11 | Firma Willi Moller | Dicarboxylic acid diamides, process for their preparation, ion selective members and test means containing them as well as lithium complexes of the dicarboxylic acid amides |
US5041291A (en) * | 1987-01-03 | 1991-08-20 | Hoechst Aktiengesellschaft | Biodegradable poly(hydroxyalkyl)amino dicarboxylic acid) derivatives, a process for their preparation, and the use thereof for depot formulations with controlled deivery of active ingredient |
US5077278A (en) | 1987-01-23 | 1991-12-31 | Pfizer Inc. | Non-natural demethylavermectins compositions and method of use |
US5069936A (en) | 1987-06-25 | 1991-12-03 | Yen Richard C K | Manufacturing protein microspheres |
US5328992A (en) | 1987-07-23 | 1994-07-12 | Ciba-Geigy Corp. | Metal complexes of polyethylene glycol carbamate derivatives of desferrioxamine B |
US5067961A (en) | 1988-02-18 | 1991-11-26 | Autogenesis Technologies, Inc. | Non-biodegradable two phase corneal implant and method for preparing same |
US5100669A (en) | 1988-02-24 | 1992-03-31 | Biomaterials Universe, Inc. | Polylactic acid type microspheres containing physiologically active substance and process for preparing the same |
US5055300A (en) * | 1988-06-17 | 1991-10-08 | Basic Bio Systems, Inc. | Time release protein |
US5066487A (en) | 1988-09-14 | 1991-11-19 | Rhone-Poulenc Chimie | Antisudoral composition comprising dibasic aluminium salts of acylated amino acids |
EP0366277B1 (en) | 1988-09-29 | 1993-12-15 | Patralan Limited | Pharmaceutical formulations |
EP0365183B1 (en) | 1988-10-10 | 1993-02-10 | Smith Kline & French Laboratories Limited | Biologically active compounds |
US5039481A (en) * | 1988-12-16 | 1991-08-13 | Clean Air, Inc. | Aliphatic polycarboxylic acids as air purification compositions |
US4983402A (en) * | 1989-02-24 | 1991-01-08 | Clinical Technologies Associates, Inc. | Orally administerable ANF |
US4976968A (en) * | 1989-02-24 | 1990-12-11 | Clinical Technologies Associates, Inc. | Anhydrous delivery systems for pharmacological agents |
US5278148A (en) | 1989-03-28 | 1994-01-11 | Hoffmann-La Roche Inc. | Amino acid derivatives useful for treating high blood pressure |
US5122367A (en) | 1989-03-31 | 1992-06-16 | Massachusetts Institute Of Technology | Polyanhydride bioerodible controlled release implants for administration of stabilized growth hormone |
US4963364A (en) * | 1989-04-10 | 1990-10-16 | Fox Sidney W | Microencapsulated antitumor agent |
US5019400A (en) * | 1989-05-01 | 1991-05-28 | Enzytech, Inc. | Very low temperature casting of controlled release microspheres |
US5100918A (en) | 1989-05-25 | 1992-03-31 | Sterling Drug, Inc. | Prevention or treatment of sunburn using the S(+) isomer of ibuprofen |
US4996292A (en) * | 1989-06-30 | 1991-02-26 | Fox Sidney W | Self-sealing artificial skin comprising copoly-alpha-amino acid |
EP0418642B1 (en) | 1989-09-11 | 1993-06-09 | Teikoku Seiyaku Kabushiki Kaisha | High-absorbable transvaginal preparation containing biologically active peptides |
US5271961A (en) | 1989-11-06 | 1993-12-21 | Alkermes Controlled Therapeutics, Inc. | Method for producing protein microspheres |
US5216124A (en) | 1989-12-15 | 1993-06-01 | G. D. Searle & Co. | Substituted cyclic tetrapeptides |
US5389377A (en) | 1989-12-22 | 1995-02-14 | Molecular Bioquest, Inc. | Solid care therapeutic compositions and methods for making same |
US5126147A (en) | 1990-02-08 | 1992-06-30 | Biosearch, Inc. | Sustained release dosage form |
US5204099A (en) | 1990-02-12 | 1993-04-20 | Sanofi | Cosmetic composition containing amino acid copolymers which is useful as a moisturizer |
EP0452161A1 (en) | 1990-02-12 | 1991-10-16 | Elf Sanofi | Cosmetic composition containing amino acids copolymers, useful as hydrating agent |
EP0448057B1 (en) | 1990-03-19 | 1996-05-08 | Bristol-Myers Squibb Company | Monoclonal antibody reactive with a novel HLA determinant on MHC class I molecules and method for activating lymphocytes |
EP0459795B1 (en) | 1990-06-01 | 1994-10-26 | Kirin-Amgen, Inc. | Oral dosage form of biologically active proteins |
EP0467389A3 (en) | 1990-07-19 | 1994-02-02 | Univ Kentucky Res Found | |
US5206384A (en) | 1990-09-04 | 1993-04-27 | Zaidan Hojin Biseibutsu Kagaku Kai | Actinonin derivatives and pharmaceutically acceptable salts thereof |
US5418010A (en) | 1990-10-05 | 1995-05-23 | Griffith Laboratories Worldwide, Inc. | Microencapsulation process |
US5186947A (en) | 1990-10-20 | 1993-02-16 | Dr. Wolman Gmbh | Wood preservative based on polymeric nitrogen compounds and metal-fixing acids |
US5271934A (en) | 1990-10-22 | 1993-12-21 | Revlon Consumer Products Corporation | Encapsulated antiperspirant salts and deodorant/antiperspirants |
US5137892A (en) | 1990-12-12 | 1992-08-11 | Abbott Laboratories | Quinoline, naphthyridine and pyridobenzoxazine derivatives |
US5244653A (en) | 1991-05-01 | 1993-09-14 | Isp Chemicals Inc. | Glycine anhydride dimethylol as a biocide and preservative |
US5250236A (en) | 1991-08-05 | 1993-10-05 | Gasco Maria R | Method for producing solid lipid microspheres having a narrow size distribution |
US5389379A (en) | 1992-02-18 | 1995-02-14 | Akzo N.V. | Process for the preparation of biologically active material containing polymeric microcapsules |
US5352461A (en) | 1992-03-11 | 1994-10-04 | Pharmaceutical Discovery Corporation | Self assembling diketopiperazine drug delivery system |
US5310535A (en) | 1992-04-24 | 1994-05-10 | The Dow Chemical Company | Carboxamide modified polyamine chelators and radioactive complexes thereof for conjugation to antibodies |
US5443841A (en) | 1992-06-15 | 1995-08-22 | Emisphere Technologies, Inc. | Proteinoid microspheres and methods for preparation and use thereof |
US5447728A (en) | 1992-06-15 | 1995-09-05 | Emisphere Technologies, Inc. | Desferrioxamine oral delivery system |
US5601846A (en) | 1992-06-15 | 1997-02-11 | Emisphere Technologies, Inc. | Proteinoid microspheres and methods for preparation and use thereof |
US5578323A (en) | 1992-06-15 | 1996-11-26 | Emisphere Technologies, Inc. | Proteinoid carriers and methods for preparation and use thereof |
US5705529A (en) | 1992-06-30 | 1998-01-06 | Gyogyszerkutato Intezet Kft | N-benzoyl amino acid derivatives pharmaceutical compositions containing them and process for preparing same |
US5540939A (en) | 1992-12-21 | 1996-07-30 | Emisphere Technologies, Inc. | Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof |
US5401516A (en) | 1992-12-21 | 1995-03-28 | Emisphere Technologies, Inc. | Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof |
US5451410A (en) | 1993-04-22 | 1995-09-19 | Emisphere Technologies, Inc. | Modified amino acids for encapsulating active agents |
US5536813A (en) | 1993-04-23 | 1996-07-16 | Rhone-Poulenc Chimie | Detersive polyanhydroaspartic acids and biodegradable hydrolysates thereof |
US5541155A (en) | 1994-04-22 | 1996-07-30 | Emisphere Technologies, Inc. | Acids and acid salts and their use in delivery systems |
Non-Patent Citations (239)
Title |
---|
(1985) Chemical Abstracts , vol. No. 102(6), Abstract No. 50870d. * |
(1985) Chemical Abstracts , vol. No. 105(1), Abstract No. 12027p. * |
(1985) Chemical Abstracts, vol. No. 102(6), Abstract No. 50870d. |
(1985) Chemical Abstracts, vol. No. 105(1), Abstract No. 12027p. |
AAPS 6th Ann. Meeting and Expo., "Proteinoids--A Novel Drug Delivery System" Nov. 19, 1992, p. 33. |
Airaudo, C.B. et al. (1987) Journal of Food Science , vol. 52(6), pp. 1750 1752. * |
Airaudo, C.B. et al. (1987) Journal of Food Science, vol. 52(6), pp. 1750-1752. |
Amino, Y., et al., Chem. Pharm. Bull. 36 (11):4426 4434 (1988). * |
Amino, Y., et al., Chem. Pharm. Bull. 36(11):4426-4434 (1988). |
Andini, S. et al. (1975) Origins of Life , vol. 6, pp. 147 153. * |
Andini, S. et al. (1975) Origins of Life, vol. 6, pp. 147-153. |
Andrea Leone-Bay et al., Journal of Medicinal Chemistry, vol. 38, No. 21, pp. 4263-4269, (1995), "N-Acylated α-Amino Acids as Novel Oral Delivery Agents for Proteins". |
Andriuoli, G., et al. (1990), Haemostasis 20 (suppl. 1):154 158. * |
Andriuoli, G., et al. (1990), Haemostasis 20 (suppl. 1):154-158. |
Baughman et al., "Screening Candidate Microsphere Formulations By Incubating In Simulated Digestive Fluids" Proc. of the 6th Intern'l. Sympo. on Recent Advances in Drug Delivery Systems, Ctr. for Controlled Chem. Delivery, University of Utah, Feb. 22-25, 1993, pp. 181-182. |
Baughman, R.A. et al., Proc. of the 6th Inter l. Symp. on Recent Advs. in Drug Delivery Systems, Ctr. for Controlled Chem. Delivery, University of Utah , Feb. 22 25, 1993, Salt Lake City, UT, pp. 179 180 Method for Assessing The Stability of Proteinoid Microspheres . * |
Baughman, R.A. et al., Proc. of the 6th Inter'l. Symp. on Recent Advs. in Drug Delivery Systems, Ctr. for Controlled Chem. Delivery, University of Utah, Feb. 22-25, 1993, Salt Lake City, UT, pp. 179-180 "Method for Assessing The Stability of Proteinoid Microspheres". |
Bergeron, Raymond et al., "A Comparative Evaluation of Iron Clearance Models", Annals New York Academy of Sciences, pp. 278-393. |
Bergeron, Raymond et al., A Comparative Evaluation of Iron Clearance Models , Annals New York Academy of Sciences , pp. 278 393. * |
Bergeron, Raymond J., et al. (1991) "Evaluation of Desferrithiocin and Its Synthetic Analogs as Orally Effective Iron Chelators", Journal of Medicinal Chemistry, vol. 34, No. 7, pp. 2072-2078. |
Bergeron, Raymond J., et al. (1991) Evaluation of Desferrithiocin and Its Synthetic Analogs as Orally Effective Iron Chelators , Journal of Medicinal Chemistry , vol. 34, No. 7, pp. 2072 2078. * |
Bergeron, Raymond J., et al. (1993) "A Comparative Study of the Iron-Clearing Properties of Desferrithiocin Analogues With Desferrioxamine B in a Cebus Monkey Model", Blood, vol. 81, No. 8, pp. 2166-2173. |
Bergeron, Raymond J., et al. (1993) A Comparative Study of the Iron Clearing Properties of Desferrithiocin Analogues With Desferrioxamine B in a Cebus Monkey Model , Blood , vol. 81, No. 8, pp. 2166 2173. * |
Bergeron, Raymond J., et al. (1994) "Macromolecular Self-Assembly of Diketopiperazine Tetrapeptides", Journal of the American Chemical Society, vol. 116, pp. 8479-8484. |
Bergeron, Raymond J., et al. (1994) Macromolecular Self Assembly of Diketopiperazine Tetrapeptides , Journal of the American Chemical Society , vol. 116, pp. 8479 8484. * |
Bergeron, Raymond J., et al., (1992) "A Comparison of the Iron-Clearing Properties of 1,2-Dimethyl-3-Hydroxypyrid-4-One, 1,2-Diethyl-3-Hydroxypyrid-4-One, and Deferoxamine", Blood, vol. 79, No. 7, pp. 1882-1890. |
Bergeron, Raymond J., et al., (1992) A Comparison of the Iron Clearing Properties of 1,2 Dimethyl 3 Hydroxypyrid 4 One, 1,2 Diethyl 3 Hydroxypyrid 4 One, and Deferoxamine , Blood , vol. 79, No. 7, pp. 1882 1890. * |
Bernadette Earley et al., Brain Research, vol. 546:282-286, 1991. |
Bernstein (1985), Chest 87 (1):68S 73S. * |
Bernstein (1985), Chest 87(1):68S-73S. |
Brendan D. Curti, Critical Reviews in Oncology/Hematology, 1993: 14 pp. 29-39 "Physical barriers to drug delivery in tumors". |
Brooke, S. 1 et al. (1977) BioSystems , vol. 9, pp. 1 22. * |
Brooke, S. 1 et al. (1977) BioSystems, vol. 9, pp. 1-22. |
C.A. Finch, Chemistry and Industry, vol. 22:752-756, 1985. |
Caramazza, I., et al. (1991), Thrombosis Research 62 :785 789. * |
Caramazza, I., et al. (1991), Thrombosis Research 62:785-789. |
Chemical Abstract , vol. 80(9) Abst. No. 52392a. * |
Chemical Abstract, vol. 80(9) Abst. No. 52392a. |
Chemical Abstracts :83 184360k, (1975). * |
Chemical Abstracts, 112(15):134663h, (1989). |
Chemical Abstracts, 114(22):214519x, (1990). |
Chemical Abstracts, 76(14):72994u, (1971). |
Chemical Abstracts, 84(7):44660d, (1975). |
Chemical Abstracts, 86(16):107529g, (1976). |
Chemical Abstracts, 99(19) 158832b, (1982). |
Chemical Abstracts:83 184360k, (1975). |
Chen et al. (1975) "Evidence for Hemiacetal Formation", Biochemistry, vol. 18, No. 5, pp. 921-925. |
Chen et al. (1975) Evidence for Hemiacetal Formation , Biochemistry , vol. 18, No. 5, pp. 921 925. * |
Dal Pozzo, A., et al. (1989), Thrombosis Research 56 :119 124. * |
Dal Pozzo, A., et al. (1989), Thrombosis Research 56:119-124. |
Damge et al. (1988), Diabetes 37 :246 251. * |
Damge et al. (1988), Diabetes 37:246-251. |
Davis et al. (1983) "Leucinal Inhibits . . . ", Pharmacology Biochemistry Behaviour, vol. 19, pp. 791-794. |
Davis et al. (1983) Leucinal Inhibits . . . , Pharmacology Biochemistry Behaviour , vol. 19, pp. 791 794. * |
Derwent Abstracts, JP 67008622, (1967). |
Doris K. Chiappetta, Eastern Analytical Symposium, Nov. 17, 1992 "Solutions for Problems in Bioanalysis". |
Dose, K. (1974) Origins of Life , vol. 5, pp. 239 252. * |
Dose, K. (1974) Origins of Life, vol. 5, pp. 239-252. |
Elizabeth A. Harris. M.S., Eastern Analytical Symposium, Nov. 17, 1992 "Solutions for Problems in Bioanalysis". |
Fasman et al. (1964) Biochemistry , vol. 3, No. 11, pp. 1665 1674. * |
Fasman et al. (1964) Biochemistry, vol. 3, No. 11, pp. 1665-1674. |
Fox, S.W. (1976) Origins of Life , vol. 7, pp. 49 68. * |
Fox, S.W. (1976) Origins of Life, vol. 7, pp. 49-68. |
Fox, S.W. (1980) Naturwissenschaften , vol. 67, pp. 378 383. * |
Fox, S.W. (1980) Naturwissenschaften, vol. 67, pp. 378-383. |
Fox, S.W. (1984) Origins of Life , vol. 14, pp. 485 488. * |
Fox, S.W. (1984) Origins of Life, vol. 14, pp. 485-488. |
Fox, S.W. et al. (1960) Archives of Biochemistry and Biophysics , vol. 86, pp. 281 285. * |
Fox, S.W. et al. (1960) Archives of Biochemistry and Biophysics, vol. 86, pp. 281-285. |
Fox, S.W. et al. (1968) Biochim. Biophys. Acta , vol. 160, pp. 246 249. * |
Fox, S.W. et al. (1968) Biochim. Biophys. Acta, vol. 160, pp. 246-249. |
Fox, S.W. et al. (1974) Origins of Life , vol. 5, pp. 227 237. * |
Fox, S.W. et al. (1974) Origins of Life, vol. 5, pp. 227-237. |
Fox, S.W. et al. (1976) BioSystems , vol. 8, pp. 40 44. * |
Fox, S.W. et al. (1976) BioSystems, vol. 8, pp. 40-44. |
Fox, S.W. et al., Molecular Evolution and the Origin of Life , Maxel Decker, New York (1977). * |
Fox, S.W. et al., Molecular Evolution and the Origin of Life, Maxel Decker, New York (1977). |
Gelb, R., et al (1983), Lite Sciences 33 (1):83 85. * |
Gelb, R., et al (1983), Lite Sciences 33(1):83-85. |
Gol dovskii, A.M. (1978) Zhurnal Evolyutsionnoi Biokhimii i Fiziologii , vol. 14(6), pp. 437 439. * |
Gol'dovskii, A.M. (1978) Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, vol. 14(6), pp. 437-439. |
Guarini, S., et al. (1983), Experimentia 41 :350 352. * |
Guarini, S., et al. (1983), Experimentia 41:350-352. |
Guarini, S., et al. (1985), Pharmacological Research Communications 17 (8):685 697. * |
Guarini, S., et al. (1985), Pharmacological Research Communications 17(8):685-697. |
Gurrieri, S. et al. (1973) Thermochimica Acta , vol. 7, pp. 231 239. * |
Gurrieri, S. et al. (1973) Thermochimica Acta, vol. 7, pp. 231-239. |
Haas, S. et al., "Assessment Of Stability Of Proteinoid Microspheres", Proceed. Intern. Symp. Control. Rel. Biact. Mater., 20 (1993), Controlled Release Society, Inc.,. |
Haas, S. et al., Assessment Of Stability Of Proteinoid Microspheres , Proceed. Intern. Symp. Control. Rel. Biact. Mater. , 20 (1993), Controlled Release Society, Inc.,. * |
Harada et al., (1960) Archives of Biochemistry and Biophysics , vol. 86, pp. 274 280. * |
Harada et al., (1960) Archives of Biochemistry and Biophysics, vol. 86, pp. 274-280. |
Harada, K. et al. (1979) BioSystems , vol. 11, pp. 47 53. * |
Harada, K. et al. (1979) BioSystems, vol. 11, pp. 47-53. |
Hare (1970) Etude Cenetique De La Polycondensation Thermique D X Amino Acides , vol. 45, pp. 330 339. * |
Hare (1970) Etude Cenetique De La Polycondensation Thermique D'X -Amino Acides, vol. 45, pp. 330-339. |
Heinrich, M.R. et al. (1969) Archives of Biochemistry and Biophysics , vol. 130, pp. 441 448. * |
Heinrich, M.R. et al. (1969) Archives of Biochemistry and Biophysics, vol. 130, pp. 441-448. |
Heinz, B. et al. (1981) BioSystems , vol. 14, pp. 33 40. * |
Heinz, B. et al. (1981) BioSystems, vol. 14, pp. 33-40. |
Hennon, G. et al. (1975) Biochimie , vol. 57, pp. 1395 1396. * |
Hennon, G. et al. (1975) Biochimie, vol. 57, pp. 1395-1396. |
Hitoshi Oinuma et al., J. Med Chem., vol. 33:903-905, 1990. |
Hsu, L.L. et al. (1971) Currents in Modern Biology , vol. 4, pp. 12 25. * |
Hsu, L.L. et al. (1971) Currents in Modern Biology, vol. 4, pp. 12-25. |
Hsu, L.L. et al. (1976) BioSystems , vol. 8, pp. 89 101. * |
Hsu, L.L. et al. (1976) BioSystems, vol. 8, pp. 89-101. |
Ishima, Y. et al. (1981), BioSystems , vol. 14, pp. 243 251. * |
Ishima, Y. et al. (1981), BioSystems, vol. 14, pp. 243-251. |
J. Gyore et al., Thermal Analysis, vol. 2--Proceeding Fourth ICTA Budapest 1974, pp. 387-394. |
Jackson et al. (1991) "Pharmacological . . . ", J. Pharm. & Exp. Thera., vol. 261, No. 1, pp. 546-552. |
Jackson et al. (1991) Pharmacological . . . , J. Pharm. & Exp. Thera. , vol. 261, No. 1, pp. 546 552. * |
John A. Butera et al., J. Med. Chem., vol. 34:3212-3228, 1990. |
John W. Ellingboe et al., J. Med Chem., vol. 35:705-716, 1992. |
Joseph J. Lynch et al., J. of Pharm. and Exp. Therap., vol. 269:541-554, 1994. |
Journal of Medicinal Chemistry, vol. 38, No. 21, pp. 4257-4262, (1995), "Microsphere Formation in a Series of Derivatized α-Amino Acids: Properties, Molecular Modeling, and Oral Delivery of Salmon Calcitonin". |
Jungck, J.R. et al. (1973) Naturwissenschaften , vol. 60, pp. 425 427. * |
Jungck, J.R. et al. (1973) Naturwissenschaften, vol. 60, pp. 425-427. |
Kiyoshi Matsuno et al., Brain Research, vol. 575:315-319, 1992. |
Kokufuta, E. et al. (1984) BioSystems , vol. 16, pp. 175 181. * |
Kokufuta, E. et al. (1984) BioSystems, vol. 16, pp. 175-181. |
Krampitz, G. et al. (1966) Naturwissenschaften , pp. 7 and 8. * |
Krampitz, G. et al. (1966) Naturwissenschaften, pp. 7 and 8. |
Krampitz, G. et al. (1967) Naturwissenschaften , pp. 516 517. * |
Krampitz, G. et al. (1967) Naturwissenschaften, pp. 516-517. |
Krampitz, G. et al. (1968) Naturwissenschaften , pp. 345 346. * |
Krampitz, G. et al. (1968) Naturwissenschaften, pp. 345-346. |
Lacey, Jr., J.C. et al. (1979) BioSystems , vol. 11, pp. 1 7. * |
Lacey, Jr., J.C. et al. (1979) BioSystems , vol. 11, pp. 9 17. * |
Lacey, Jr., J.C. et al. (1979) BioSystems, vol. 11, pp. 1-7. |
Lacey, Jr., J.C. et al. (1979) BioSystems, vol. 11, pp. 9-17. |
Leipold et al., Pharm. Res. 11: 1994, p. S 298 Oral Delivery of Interferon in Rats and Primates . * |
Leipold et al., Pharm. Res. 11: 1994, p. S-298 "Oral Delivery of Interferon in Rats and Primates". |
Leone Bay et al., Pharm. Res. 11: 1994, p. S 121 Oral Delivery of Heparin using Acylated Amino Acids . * |
Leone Bay et al., Presented at Winter Conference on Medicinal and Bioorganic Chemistry Steamboat Springs, Colorado Feb. 1995 Microsphere Formation and Drug Delivery in a Series of Derivatized Amino Acids . * |
Leone-Bay et al., Pharm. Res. 11: 1994, p. S-121 "Oral Delivery of Heparin using Acylated Amino Acids". |
Leone-Bay et al., Presented at "Winter Conference on Medicinal and Bioorganic Chemistry" Steamboat Springs, Colorado--Feb. 1995 "Microsphere Formation and Drug Delivery in a Series of Derivatized Amino Acids". |
Madeline G. Cimini et al., Ann. Report in Med Chem., vol. 27:89-98., 1992. |
Martinez Luque Romero, M. et al. (1986) BioSystems , vol. 19, pp. 267 272. * |
Martinez Luque-Romero, M. et al. (1986) BioSystems, vol. 19, pp. 267-272. |
Masinovsky, Z. et al. (1989) BioSystems , vol. 22, pp. 305 310. * |
Masinovsky, Z. et al. (1989) BioSystems, vol. 22, pp. 305-310. |
Matsuno, K. (1981) BioSystems , vol. 14, pp. 163 170. * |
Matsuno, K. (1981) BioSystems, vol. 14, pp. 163-170. |
Matsuno, K. (1982) BioSystems , vol. 15, pp. 1 11. * |
Matsuno, K. (1982) BioSystems, vol. 15, pp. 1-11. |
Matsuno, K. (1984) BioSystems , vol. 17, pp. 11 14. * |
Matsuno, K. (1984) BioSystems, vol. 17, pp. 11-14. |
McAlhaney, W.W. et al. (1976) BioSystems , vol. 8, pp. 45 50. * |
McAlhaney, W.W. et al. (1976) BioSystems, vol. 8, pp. 45-50. |
Melius, P. (1979) BioSystems , vol. 11, pp. 125 132. * |
Melius, P. (1979) BioSystems, vol. 11, pp. 125-132. |
Melius, P. et al. (1975) Bioorganic Chemistry , vol. 4, pp. 385 391. * |
Melius, P. et al. (1975) Bioorganic Chemistry, vol. 4, pp. 385-391. |
Melius, P. et al. (1987) BioSystems , vol. 20, pp. 213 217. * |
Melius, P. et al. (1987) BioSystems, vol. 20, pp. 213-217. |
Michael E. Osband et al., Immunology Today, vol. 11, No.6 1990, pp. 93-95, "Problems in the investigational study and clinical use of cancer immunotherapy". |
Milstein et al. "Preparation And In Vitro Characterization Of Proteinoid Microspheres" Proceed Intern. Symp. Control. Rel. Bioact. Mater., 19 (1992), Controlled Release Society, Inc. pp. 516-517. |
Milstein et al., "Efficient Oral Delivery Of Monoclonal Antibodies By Proteinoid Encapsulation" The 1993 Miami Bio/Technology Winter Symposium--Advances in Gene Technology: Protein Engineering and Beyond, Jan. 17-22, 1993. |
Milstein et al., Symposia Abstracts. AAPS Annual Meeting, San Antonia, TX, Nov. 15-19, 1993. |
Miquel, J. et al. (1971) Currents in Modern Biology , vol. 3, pp. 299 306. * |
Miquel, J. et al. (1971) Currents in Modern Biology, vol. 3, pp. 299-306. |
Nakashima, T. et al. (1980) J. Mol. Evol. , vol. 15, pp. 161 168. * |
Nakashima, T. et al. (1980) J. Mol. Evol., vol. 15, pp. 161-168. |
Nakashima, T. et al. (1981) BioSystems , vol. 14, pp. 151 161. * |
Nakashima, T. et al. (1981) BioSystems, vol. 14, pp. 151-161. |
Novak, V.J.A. (1984) Origins of Life , vol. 14, pp. 513 522. * |
Novak, V.J.A. (1984) Origins of Life, vol. 14, pp. 513-522. |
Olafsson, P.G. et al. (1971) Polymer Letters , vol. 9, pp. 521 528. * |
Olafsson, P.G. et al. (1971) Polymer Letters, vol. 9, pp. 521-528. |
Phillips, R.D. et al. (1974) Int. J. Peptide Protein Res. , vol. 6, pp. 309 319. * |
Phillips, R.D. et al. (1974) Int. J. Peptide Protein Res., vol. 6, pp. 309-319. |
Presented at "IBC Rational Drug Design Conference", San Diego, Calif.--Dec. 1994. |
Presented at IBC Rational Drug Design Conference , San Diego, Calif. Dec. 1994. * |
Przybylski, A.T. (1985) BioSystems , vol. 17, pp. 281 288. * |
Przybylski, A.T. (1985) BioSystems, vol. 17, pp. 281-288. |
Przybylski, A.T. et al. (1982) Die Naturwissenschaften , vol. 69, pp. 561 563. * |
Przybylski, A.T. et al. (1982) Die Naturwissenschaften, vol. 69, pp. 561-563. |
Przybylski, A.T. et al. (1984) Applied Biochemistry and Biotechnology , vol. 10, pp. 301 307. * |
Przybylski, A.T. et al. (1984) Applied Biochemistry and Biotechnology, vol. 10, pp. 301-307. |
Robert O. Dillman, M.D., Annals of Internal Medicine 1989:111 pp. 592-600, "Monoclonal Antibodies for Treating Cancer". |
Rohlfing, D.L. (1967) Archives of Biochemistry and Biophysics , vol. 118, pp. 468 474. * |
Rohlfing, D.L. (1967) Archives of Biochemistry and Biophysics, vol. 118, pp. 468-474. |
Rohlfing, D.L. (1970) Science , vol. 169, pp. 998 1000. * |
Rohlfing, D.L. (1970) Science, vol. 169, pp. 998-1000. |
Rohlfing, D.L. (1975) Origins of Life , vol. 6, pp. 203 209. * |
Rohlfing, D.L. (1975) Origins of Life, vol. 6, pp. 203-209. |
Rohlfing, D.L. et al. (1976) BioSystems , vol. 8, pp. 139 145. * |
Rohlfing, D.L. et al. (1976) BioSystems, vol. 8, pp. 139-145. |
Rohlfing, D.L. et al. Catalytic Activities of Thermal Polyanhydro Amino Acids , pp. 373 418. * |
Rohlfing, D.L. et al. Catalytic Activities of Thermal Polyanhydro-α-Amino Acids, pp. 373-418. |
Ryan, J.W. et al. (1973) BioSystems , vol. 5, pp. 115 118. * |
Ryan, J.W. et al. (1973) BioSystems, vol. 5, pp. 115-118. |
Santiago et al. "Initial Studies In The Assessment of Proteinoid Microsphere Activity" Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 20 (1993), Controlled Release Society, Inc. |
Santiago et al. "Oral Immunization of Rats with Influenza Virus M Protein (M1) Microspheres" Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 19 (1992), Controlled Release Society, Inc., pp. 116-117. |
Santiago et al. "Proteinoid Microspheres For The Oral Delivery of Heparin" Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 19 (1992), Controlled Release Society, Inc. pp. 514-515. |
Santiago et al. American Society for Microbiology 92nd General Meeting, Abstract of the General Meeting, p. 159, May 26-30, 1992. |
Santiago et al., Pharm. Res. 11: 1994, p. S 298 Evaluation in Rats of Vehicles for the Oral Delivery of Low Molecular Weight Heparin . * |
Santiago et al., Pharm. Res. 11: 1994, p. S-298 "Evaluation in Rats of Vehicles for the Oral Delivery of Low Molecular Weight Heparin". |
Santiago et al., Pharm. Res. 11:1994, p. S 298 Oral Delivery of Heparin Microspheres made with Modified Amino Acids . * |
Santiago et al., Pharm. Res. 11:1994, p. S-298 "Oral Delivery of Heparin Microspheres made with Modified Amino Acids". |
Sarubbi et al., Pharm. Res. 11: 1994, p. S 299 Oral Calcitonin Delivery using the PODDS Technology . * |
Sarubbi et al., Pharm. Res. 11: 1994, p. S-299 "Oral Calcitonin Delivery using the PODDS Technology". |
Saunders, M.A. et al. (1974) BioSystems , vol. 6, pp. 81 92. * |
Saunders, M.A. et al. (1974) BioSystems, vol. 6, pp. 81-92. |
Snyder, W.D. et al. (1975) BioSystems , vol. 7, pp. 222 229. * |
Snyder, W.D. et al. (1975) BioSystems, vol. 7, pp. 222-229. |
Sokol, P.E. (1974) Journal of the American Oil Chemists Society , vol. 52, pp. 101 102. * |
Sokol, P.E. (1974) Journal of the American Oil Chemists'Society, vol. 52, pp. 101-102. |
Stephen J. Douglas et al., Chemistry and Industry, vol. 22:748-751, 1985. |
Tadimeti S. Rao et al., Molecular Pharmacology, vol.37:978-982, 1990. |
The Extra Pharmacopoeia, Thirtieth Edition, pp. 325-326, (1993). |
Thomas A. Waldmann, Science, Jun. 21, 1991, 252:1657-1662, "Monoclonal Antibodies in Diagnosis and Therapy". |
Thomas K. Morgan et al., J. Med. Chem., vol. 33:1091-1097, 1990. |
Tschager et al. (1988) Milchwirtschaftliche Berichte , vol. 95, pp. 79 83. * |
Tschager et al. (1988) Milchwirtschaftliche Berichte, vol. 95, pp. 79-83. |
V. Hird et al, Genes and Cancer, edited by Desmond Carney & Karol Sikora, pp. 183-189, Immunotherapy with Monoclonal Antibodies. |
Vaughan, G. et al. (1987) BioSystems , vol. 20, pp. 219 223. * |
Vaughan, G. et al. (1987) BioSystems, vol. 20, pp. 219-223. |
Vol kenshtein, M.V. (1989) Molekulyarnaya Biologiya , vol. 23(1), pp. 23 37. * |
Vol'kenshtein, M.V. (1989) Molekulyarnaya Biologiya, vol. 23(1), pp. 23-37. |
Waehneldt, T.V. et al. (1968) Biochim. Biophys. Acta , vol. 160, pp. 239 245. * |
Waehneldt, T.V. et al. (1968) Biochim. Biophys. Acta, vol. 160, pp. 239-245. |
Watterberg et al. (1988), Pediatric Research , vol. 23, No. 4, part 2, p. 570A, col. 1, abstract No. 2209. * |
Watterberg et al. (1988), Pediatric Research, vol. 23, No. 4, part 2, p. 570A, col. 1, abstract No. 2209. |
William C. Lumma et al., J. Med Chem., vol. 30:758-763, 1987. |
William J. Harris, Tibtech Feb. 1993 vol. 11, pp. 42-44 "Therapeutic antibodies--the coming of age". |
Williams et al. (1991) J. Biol. Chem. , vol. 266, No. 8, pp. 5182 5190. * |
Williams et al. (1991) J. Biol. Chem., vol. 266, No. 8, pp. 5182-5190. |
X. Ma et al., PDD 7303 Pharmaceutical Research 9 (10):S 244, 1992 (Oct. Supplement). * |
X. Ma et al., PDD 7303 Pharmaceutical Research 9(10):S-244, 1992 (Oct. Supplement). |
X. Ma, et al., Proceed. Intern. Symp. Control. Rel. Bioact. Mater. , 20 (1993), Controlled Release Society, Inc. In Vitro Mechanistic Investigation of the Proteinoid Microsphere Oral Delivery System . * |
X. Ma, et al., Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 20 (1993), Controlled Release Society, Inc. "In Vitro Mechanistic Investigation of the Proteinoid Microsphere Oral Delivery System". |
Xinghang Ma, et al. "Stability Study of Drug-loaded Proteinoid Microsphere Formulations during Freeze-drying" Journal of Drug Targeting, 1994, vol. 2, pp. 9-21. |
Yen, H. R H., et al., Adsorption of Sulforhodamine 101 on Proteinoid Microspheres Proceed. Intern. Symp. Control. Rel. Bioact. Mater. , 20 (1993), Controlled Release Society, Inc. * |
Yen, H.-R H., et al., "Adsorption of Sulforhodamine 101 on Proteinoid Microspheres" Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 20 (1993), Controlled Release Society, Inc. |
Yuki, A. et al. (1969) Biochemical and Biophysical Research Communications , vol. 36(4), pp. 657 663. * |
Yuki, A. et al. (1969) Biochemical and Biophysical Research Communications, vol. 36(4), pp. 657-663. |
Zulaski et al. (1983) "New Carboxyalkyl Inhibitors of Brain Enkenphalinase", J. Med. Chem., 26, pp. 60-65. |
Zulaski et al. (1983) New Carboxyalkyl Inhibitors of Brain Enkenphalinase , J. Med. Chem. , 26, pp. 60 65. * |
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US9364502B2 (en) | 2006-06-28 | 2016-06-14 | Emisphere Technologies, Inc. | Gallium nitrate formulations |
US20100015088A1 (en) * | 2006-08-31 | 2010-01-21 | Emisphere Technologies Inc. | Compounds and compositions for delivering active agents |
USRE48164E1 (en) | 2006-08-31 | 2020-08-18 | Emisphere Technologies Inc. | Compounds and compositions for delivering active agents |
US8895777B2 (en) | 2006-08-31 | 2014-11-25 | Emisphere Technologies Inc | Compounds and compositions for delivering active agents |
US9119835B2 (en) | 2007-03-13 | 2015-09-01 | JDS Therapeautics, LLC | Methods and compositions for the sustained release of chromium |
US9597404B2 (en) | 2007-03-13 | 2017-03-21 | Jds Therapeutics, Llc | Methods and compositions for sustained release of chromium |
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US11850308B2 (en) | 2007-06-26 | 2023-12-26 | Bonafide Health, Llc | Multiple unit dosage form having a therapeutic agent in combination with a nutritional supplement |
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WO2011017346A2 (en) | 2009-08-03 | 2011-02-10 | Emisphere Technologies, Inc. | Fast-acting naproxen composition with reduced gastrointestinal effects |
US20110039930A1 (en) * | 2009-08-03 | 2011-02-17 | Emisphere Technologies, Inc. | Fast-acting naproxen composition with reduced gastrointestinal effects |
WO2012119007A1 (en) | 2011-03-01 | 2012-09-07 | N21 Acquisition Holding, Llc | Compositions of insulin and chromium for the treatment and prevention of diabetes, hypoglycemia and related disorders |
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EP4070801A1 (en) | 2011-03-01 | 2022-10-12 | Nutrition 21, LLC | Compositions of insulin and chromium for the treatment and prevention of diabetes, hypoglycemia and related disorders |
WO2014046983A1 (en) | 2012-09-21 | 2014-03-27 | Intensity Therapeutic | Method of treating cancer |
US11857553B2 (en) | 2016-02-11 | 2024-01-02 | Nutrition21, LLC | Chromium containing compositions for improving health and fitness |
US11865121B2 (en) | 2016-02-11 | 2024-01-09 | Nutrition21, LLC | Chromium containing compositions for improving health and fitness |
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ES2207655T3 (en) | 2004-06-01 |
FI971776A (en) | 1997-04-25 |
CA2203033A1 (en) | 1996-05-02 |
PL319833A1 (en) | 1997-09-01 |
US5643957A (en) | 1997-07-01 |
AU3963395A (en) | 1996-05-15 |
AU711887B2 (en) | 1999-10-21 |
HUT77759A (en) | 1998-07-28 |
BR9510168A (en) | 1997-10-14 |
DE69531741D1 (en) | 2003-10-16 |
JP4223547B2 (en) | 2009-02-12 |
NO971889D0 (en) | 1997-04-24 |
US6100298A (en) | 2000-08-08 |
JPH10507762A (en) | 1998-07-28 |
MX9702899A (en) | 1997-07-31 |
CA2203033C (en) | 2008-07-29 |
EP0783299A1 (en) | 1997-07-16 |
DE69531741T2 (en) | 2004-03-25 |
WO1996012473A1 (en) | 1996-05-02 |
EP0783299B1 (en) | 2003-09-10 |
CZ122997A3 (en) | 1997-10-15 |
ATE249422T1 (en) | 2003-09-15 |
EP0783299A4 (en) | 1999-06-30 |
FI971776A0 (en) | 1997-04-25 |
NO971889L (en) | 1997-06-23 |
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