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Número de publicaciónUS6139510 A
Tipo de publicaciónConcesión
Número de solicitudUS 08/545,672
Número de PCTPCT/US1994/005219
Fecha de publicación31 Oct 2000
Fecha de presentación11 May 1994
Fecha de prioridad11 May 1994
TarifaPagadas
Número de publicación08545672, 545672, PCT/1994/5219, PCT/US/1994/005219, PCT/US/1994/05219, PCT/US/94/005219, PCT/US/94/05219, PCT/US1994/005219, PCT/US1994/05219, PCT/US1994005219, PCT/US199405219, PCT/US94/005219, PCT/US94/05219, PCT/US94005219, PCT/US9405219, US 6139510 A, US 6139510A, US-A-6139510, US6139510 A, US6139510A
InventoresThomas J. Palermo
Cesionario originalTarget Therapeutics Inc.
Exportar citaBiBTeX, EndNote, RefMan
Enlaces externos: USPTO, Cesión de USPTO, Espacenet
Super elastic alloy guidewire
US 6139510 A
Resumen
This invention is a surgical device. It is a guidewire for use in a catheter and is used for accessing a targeted site in a lumen system of a patient's body. The guidewire may be of a high elasticity metal alloy, preferably a Ni-Ti alloy, having specified physical parameters, and is especially useful for accessing peripheral or soft tissue targets. A special variation of the inventive guidewire includes the concept of coating the wire with a one or more lubricious polymers to enhance its suitability for use within catheters and with the interior of vascular lumen. The "necked" guidewire tip also forms a specific variant of the invention.
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Reclamaciones(41)
I claim as my invention:
1. A guidewire suitable for guiding a catheter within a body lumen, comprising an elongated, flexible metal wire core of a super-elastic alloy having a UP of 75 ksi±10 ksi, an LP of 25 ksi±7.5 ksi measured at 3% strain and a RS of less than 0.25% where measured in a stress-strain test to 6% strain, in which at least a portion of the guidewire is coated with a polymeric material and additionally comprising a tie layer disposed between the polymeric layer and the guidewire core.
2. The guidewire of claim 1, where the guidewire has a eccentricity ratio of 1±10-4.
3. The guidewire of claim 1, having a distal section, a middle section, and a proximal section.
4. The guidewire of claim 1, in which the super-elastic alloy is Ni-Ti.
5. The guidewire of claim 3, in which the distal section is tapered to a point.
6. The guidewire of claim 5, in which the distal section is coated with a malleable metal.
7. The guidewire of claim 6, in which the malleable metal is selected from the group consisting of gold, nickel, silver, platinum, palladium and alloys thereof.
8. The guidewire of claim 6, in which the at least a portion of the malleable metal coating on the distal portion is covered by an outer coil comprising platinum, tungsten, or an alloy thereof.
9. The guidewire of claim 4, in which the distal section comprises a proximal tapered portion and a constant diameter distal portion.
10. The guidewire of claim 9, in which the distal section is coated with a malleable metal.
11. The guidewire of claim 10, in which the malleable metal is selected from the group consisting of gold, silver, platinum, palladium and alloys thereof.
12. The guidewire of claim 11, in which the at least a portion of the malleable metal coating on the distal portion is covered by an outer coil comprising platinum, tungsten, or an alloy thereof.
13. The guidewire of claim 11, wherein an inner coil surrounds the constant diameter distal portion.
14. The guidewire of claim 13, wherein the inner coil comprises a radiopaque metal selected from the group consisting of platinum, tungsten, or an alloy of the two.
15. The guidewire of claim 14, wherein a metallic ribbon secures the wire core to the inner coil and further to the outer coil.
16. The guidewire of claim 4, in which the distal section comprises a necked down portion of smaller diameter than its surrounding distal section.
17. The guidewire of claim 16, in which at least a portion of the necked down section of the distal portion is covered by an outer coil.
18. The guidewire of claim 4, in which the outer coil is connected at its distal end by a ribbon joined to the necked down section of the distal portion.
19. The guidewire of claim 18, in where an inner coil is secured between the ribbon and the necked down section all within the outer coil.
20. The guidewire of claim 1 where the polymeric material comprises polymers produced from monomers selected from ethylene oxide; 2-vinyl pyridine; N-vinylpyrrolidone; polyethylene glycol acrylates such as mono-alkoxy polyethylene glycol mono(meth) acrylates, including mono-methoxy triethylene glycol mono (meth) acrylate, mono-methoxy tetraethylene glycol mono (meth) acrylate, polyethylene glycol mono (meth) acrylate; other hydrophilic acrylates such as 2-hydroxyethylmethacrylate, glycerylmethacrylate; acrylic acid and its salts; acrylamide and acrylonitrile; acrylamidomethylpropane sulfonic acid and its salts, cellulose, cellulose derivatives such as methyl cellulose ethyl cellulose, carboxymethyl cellulose, cyanoethyl cellulose, cellulose acetate, polysaccharides such as amylose, pectin, amylopectin, alginic acid, and cross-linked heparin.
21. The guidewire of claim 1, where the tie layer disposed between the polymeric layer and the guidewire core is a heat shrunk tubing.
22. The guidewire of claim 21, where the tie layer disposed between the polymeric layer and the guidewire core is a heat shrunk tubing comprising a material selected from polyethylene terephthalate and polyurethane.
23. The guidewire of claim 21, where the tie layer disposed between the polymeric layer and the guidewire core is a heat shrunk tubing and further comprises a radiopaque material.
24. The guidewire of claim 1, where the tie layer disposed between the polymeric layer and the guidewire core is deposited by plasma.
25. The guidewire of claim 1 additionally comprising a catheter sheath.
26. A guidewire suitable for guiding a catheter within a blood vessel, comprising an elongated flexible metal wire core having a distal section including a necked down portion having a diameter smaller than a linearly contiguous section just distal of the necked down portion; an outer coil surrounding at least a portion of the distal section, such portion of the distal section comprising at least the smaller diameter portion; and a metallic ribbon securing the outer coil to the smaller diameter portion of the distal section.
27. The guidewire of claim 26, wherein an inner coil is located within the smaller diameter portion of the distal section.
28. The guidewire of claim 26, wherein the wire core comprises a material selected from the group consisting of high elasticity alloys, stainless steel, platinum, palladium, rhodium and alloys thereof.
29. The guidewire of claim 28, where the material is a Ni-Ti alloy.
30. The guidewire of claim 26, wherein the outer coil comprises a radiopaque material selected from the group consisting of platinum, tungsten, or an alloy of the two.
31. The guidewire of claim 26, wherein the inner coil comprises a radiopaque material selected from the group consisting of platinum, tungsten or an alloy of the two.
32. A guidewire suitable for guiding a catheter within a blood vessel, comprising an elongated flexible metal wire core of a super-elastic alloy having a tie layer disposed about at least a portion of the core, where said tie layer has been shrunk onto the wire core, where said tie layer comprises at least one of NYLON, polyethylene, polystyrene, polyurethane and polyethylene terephthalate, and where said tie layer further comprises one or more radio opaque material selected from barium sulfate, bismuth trioxide, bismuth carbonate, tungsten and tantalum.
33. The guidewire of claim 32, where the super-elastic alloy material is a Ni-Ti alloy.
34. The guidewire of claim 33, where the tie layer comprises at least one of NYLON, polyethylene, polystyrene, polyurethane, and polyethylene terephthalate.
35. The guidewire of claim 34, where the tie layer comprises polyethylene terephthalate or polyurethane.
36. The guidewire of claim 34, where the tie layer further comprises one or more radio opaque materials selected from barium sulfate, bismuth trioxide, bismuth carbonate, tungsten, and tantalum.
37. The guidewire of claim 32, additionally comprising a layer disposed about the tie layer comprising polymers produced from monomers selected from ethylene oxide; 2-vinyl pyridine; N-vinylpyrrolidone; polyethylene glycol acrylates such as mono-alkoxy polyethylene glycol mono(meth) acrylates, including mono-methoxy triethylene glycol mono (meth) acrylate, mono-methoxy tetraethylene glycol mono (meth) acrylate, polyethylene glycol mono (meth) acrylate; other hydrophilic acrylates such as 2-hydroxyethylmethacrylate, glycerylmethacrylate; acrylic acid and its salts; acrylamide and acrylonitrile; acrylamidomethylpropane sulfonic acid and its salts, cellulose, cellulose derivatives such as methyl cellulose ethyl cellulose, carboxymethyl cellulose, cyanoethyl cellulose, cellulose acetate, polysaccharides such as amylose, pectin, amylopectin, alginic acid, and cross-linked heparin.
38. The guidewire of claim 26, wherein said section just distal of the necked down portion is substantially flattened and has a width greater than said diameter of said necked down portion.
39. The guidewire of claim 32, where said tie layer comprises polyethylene terephthalate or polyurethane.
40. A guidewire suitable for guiding a catheter within a blood vessel, comprising an elongated flexible metal wire core of a super-elastic alloy having a tie layer disposed about at least a portion of the core, where said tie layer has been shrunk onto the wire core, and a layer disposed about said tie layer, said layer disposed about said tie layer comprising polymers produced from monomers selected from ethylene oxide; 2-vinyl pyridine; N-vinylpyrrolidone; polyethylene glycol acrylates such as mon-alkoxy polyethylene glycol mono(meth) acrylates, including mono-methoxy triethylene glycol mono(meth) acrylate, mono-methoxy tetraethylene glyco mono(meth) acrylate, polyethylene glycol mono(meth) acrylate; other hydrophilic acrylates such as 2-hydroxyethylmethacrylate, glycerylmethacrylate; acrylic acid and its salts; acrylamide and acrylonitrile; acrylamidomethylpropane sulfonic acid and its salts; cellulose; cellulose derivatives such as methyl cellulose, ethyl cellulose, carboxymethyl cellulose, cyanoethyl cellulose, cellulose acetate; polysaccharides such as amylose, pectin, amylopectin, alginic acid, and cross-linked heparin.
41. The guidewire of claim 32, where the super-elastic alloy material is a Ni-Ti alloy.
Descripción
FIELD OF THE INVENTION

This invention is a surgical device. It is a guidewire for use in a catheter and is used for accessing a targeted site in a lumen system of a patient's body. The guidewire may be of a high elasticity metal alloy, preferably a Ni-Ti alloy, having specified physical parameters, and is especially useful for accessing peripheral or soft tissue targets. A special variation of the inventive guidewire includes the coating of the wire with a one or more lubricious polymers to enhance its suitability for use within catheters and with the interior of vascular lumen. The "necked" guidewire tip also forms a specific variant of the invention.

BACKGROUND OF THE INVENTION

Catheters are used increasingly as a means for delivering diagnostic and therapeutic agents to internal sites within the human body that can be accessed through the various of the body's lumen systems, particularly through the vasculature. A catheter guidewire is used for guiding the catheter through the bends, loops, and branches forming the blood vessels within the body. One method of using a guidewire to direct the catheter through the torturous paths of these systems of lumen involves the use of a torgueable guidewire which is directed as a unit from a body access point such as the femoral artery to the tissue region containing the target site. The guidewire is typically bent at its distal end, and may be guided by alternately rotating and advancing the guidewire along the small vessel pathway to the desired target. Typically the guidewire and the catheter are advanced by alternately moving the guidewire along a distance in the vessel pathway, holding the guidewire in place, and then advancing the catheter along the axis of the guidewire until it reaches the portion of the guidewire already advanced farther into the human body.

The difficulty in accessing remote body regions, the body's periphery or the soft tissues within the body such as the brain and the liver, are apparent. The catheter and its attendant guidewire must be both flexible, to allow the combination to follow the complicated path through the tissue, and yet stiff enough to allow the distal end of the catheter to be manipulated by the physician from the external access site. It is common that the catheter is as long as a meter or more.

The catheter guidewires used in guiding a catheter through the human vasculature have a number of variable flexibility constructions. For instance, U.S. Pat. Nos. 3,789,841; 4,545,390; and 4,619,274 show guidewires in which the distal end section of the wire is tapered along its length to allow great flexibility in that remote region of the guidewire. This is so, since the distal region is where the sharpest turns are encountered. The tapered section of the wire is often enclosed in a wire coil, typically a platinum coil, to increase the column strength of the tapered wire section without significant loss of flexibility in that region and also to increase the radial capacity of the guidewire to allow fine manipulation of the guidewire through the vasculature.

Another effective guidewire design is found in U.S. Pat. No. 5,095,915 which shows a guidewire having at least two sections. The distal portion is encased in an elongated polymer sleeve having axially spaced grooves to allow increased bending flexibility of the sleeve.

Others have suggested the use of guidewires made of various super-elastic alloys in an attempt to achieve some of the noted functional desires.

U.S. Pat. No. 4,925,445, to Sakamoto et al., suggests the use of a two-portion guidewire having a body portion relatively high in rigidity and a distal end portion which is comparatively flexible. At least one portion of the body and the distal end portions is formed of super-elastic metallic materials. Although a number of materials are suggested, including Ni-Ti alloys of 49 to 58% (atm) nickel, the patent expresses a strong preference for Ni-Ti alloys in which the transformation between austentite and martensite is complete at a temperature of 10° C. or below. The reason given is that "for the guidewire to be useable in the human body, it must be in the range of 10° to 20° C. due to anesthesia at a low body temperature." The temperature of the human body is typically about 37° C.

Another document disclosing a guidewire using a metal alloy having the same composition as a Ni-Ti super-elastic alloy is WO91/15152 (to Sahatjian et al. and owned by Boston Scientific Corp.). That disclosure suggests a guidewire made of the precursor to the Ni-Ti elastic alloy. Super-elastic alloys of this type are typically made by drawing an-ingot of the precursor alloy while simultaneously heating it. In the unstressed state at room temperature, such super-elastic materials occur in the austenite crystalline phase and, upon application of stress, exhibit stress-induced austenite-martensite (SIM) crystalline transformations which produce nonlinear elastic behavior. The guidewires described in that published application, on the other hand, are said not to undergo heating during the drawing process. The wires are cold-drawn and great pain is taken to assure that the alloy is maintained well below 300° F. during each of the stages of its manufacture. This temperature control is maintained during the step of grinding the guidewire to form various of its tapered sections.

U.S. Pat. No. 4,665,906 suggests the use of stress-induced martensite (SIM) alloys as constituents in a variety of different medical devices. Such devices are said to include catheters and cannulas.

U.S. Pat. No. 4,969,890 to Sugita et al., suggests the production of a catheter having a main body fitted with a shape memory alloy member, and having a liquid injection means to supply a warming liquid to allow the shape memory alloy member to recover its original shape upon being warmed by the fluid.

U.S. Pat. No. 4,984,581, to Stice, suggests a guidewire having a core of a shape memory alloy, the guidewire using the two-way memory properties of the alloy to provide both tip-deflecting and rotational movement to the guidewire in response to a controlled thermal stimulus. The controlled thermal stimulus in this instance is provided through application of an RF alternating current. The alloy selected is one that has a transition temperature between 36° C. and 45° C. The temperature 36° C. is chosen because of the temperature of the human body; 45° C. is chosen because operating at higher temperatures could be destructive to body tissue, particularly some body proteins.

U.S. Pat. No. 4,991,602 to Amplatz et al., suggests a flexible guidewire made up of a shape memory alloy such as the nickel-titanium alloy known as nitinol. The guidewire is one having a single diameter throughout its midcourse, is tapered toward each end, and has a bead or ball at each of those ends. The bead or ball is selected to allow ease of movement through the catheter into the vasculature. The guidewire is symmetrical so that a physician cannot make a wrong choice in determining which end of the guidewire to insert into the catheter. The patent suggests that wound wire coils at the guidewire tip are undesirable. The patent further suggests the use of a polymeric coating (PTFE) and an anticoagulant. The patent does not suggest that any particular type of shape memory alloy or particular chemical or physical variations of these alloys are in any manner advantageous.

Another catheter guidewire using Ni-Ti alloys is described in U.S. Pat. No. 5,069,226, to Yamauchi, et al. Yamauchi et al. describes a catheter guidewire using a Ni-Ti alloy which additionally contains some iron, but is typically heat-treated at a temperature of about 400° to 500° C. so as to provide an end section which exhibits pseudo-elasticity at a temperature of about 37° C. and plasticity at a temperature below about 80° C. A variation is that only the end portion is plastic at the temperatures below 80° C.

U.S. Pat. No. 5,171,383, to Sagae, et al., shows a guidewire produced from a super-elastic alloy which is then subjected to a heat treatment such that the flexibility is sequentially increased from its proximal portion to its distal end portions. A thermoplastic coating or coil spring may be placed on the distal portion of the wire material. Generally speaking, the proximal end portion of the guidewire maintains a comparatively high rigidity and the most distal end portion is very flexible. The proximal end section is said in the claims to have a yield stress of approximately five to seven kg/mm2 and an intermediate portion of the guidewire is shown in the claims to have a yield stress of approximately 11 to 12 kg/mm2.

Published European Patent Application 0,515,201-A1 also discloses a guidewire produced at least in part of a superelastic alloy. The publication describes a guidewire in which the most distal portion can be bent or curved into a desired shape by a physician immediately prior to use in a surgical procedure. Proximal of the guide tip, the guidewire is of a superelastic alloy. Although nickel-titanium alloys are said to be most desirable of the class shown in that disclosure, no particular physical description of those alloys is disclosed to be any more desirable than another.

Published European Patent Application 0,519,604-A2 similarly discloses a guidewire which may be produced from a superelastic material such as nitinol. The guidewire core is coated with a plastic jacket, a portion of which may be hydrophilic and a portion of which is not.

Examples of Ni-Ti alloys are disclosed in U.S. Pat. Nos. 3,174,851; 3,351,463; and 3,753,700.

None of these disclosures suggest the guidewire composition or configuration described below.

SUMMARY OF THE INVENTION

This invention is a guidewire, preferably a guidewire suitable for introduction into the vasculature of the brain, and a method for its use. At least a distal portion of the guidewire may be of a super-elastic alloy which preferably is a Ni-Ti alloy having specific physical characteristics, e.g., a stress-strain plateau at about 75±10 ksi and another at 25±7.5 ksi (each measured at 3% strain) when the stress-strain relationship is measured to a strain of 6%.

A highly desirable variation of the inventive guidewire comprises a long wire having a proximal section, an intermediate section, and a distal section. The guidewire further may have an eccentricity ratio of 1±10-4. The distal end section is typically the most flexible of the sections and is at least about three centimeters long. Desirably, the flexible distal end section is partially tapered and is covered by a coil assembly which is connected to the distal end of the guidewire at its distal tip. The coil assembly may be attached to the distal tip by soldering, perhaps after plating or coating the distal end section with a malleable or solderable metal, such as gold. The guidewire assembly may be coated with a polymer or other material to enhance its ability to traverse the lumen of the catheter. A lubricious polymer may be placed directly upon the core wire or upon a "tie" layer. The tie layer may be a shrink-wrap tubing or a plasma deposition or may be a dip or spray coating of an appropriate material. The tie layer may also be radio opaque.

The guidewire of this invention may be of a composite in which a distal portion of the core is a super-elastic alloy of the type described below and the more proximal section or sections are of another material or configuration, e.g., stainless steel wire or rod, stainless steel hypotube, super-elastic alloy tubing, carbon fiber tubing, etc.

Ideally there will be one or more radiopaque markers placed upon the guidewire, e.g., at its distal tip and potentially along the length of the intermediate section. These markers may be used both to enhance the guidewire's radiopacity and its ability to transmit torque from the proximal end to the distal end while maintaining a desired flexibility.

A specific variation of the inventive guidewire includes a distal guidewire section having a "neck" or portion of smaller diameter surrounded by areas of larger diameter thereby allowing secure soldering of a ribbon or wire within a coil assembly which extends beyond the guidewire core distal end. The enclosed ribbon or wire may be bent or shaped prior to insertion of the guidewire into the catheter to facilitate movement of the guidewire through turns in the vasculature.

Another physical variation of this invention involves the use of grooves in the guidewire to enhance flexibility in those sections without sacrificing the guidewire's columnar strength.

This invention also includes a catheter apparatus made up of the guidewire core and a thin-walled catheter designed to be advanced along the guidewire through the vasculature for positioning at a desired site.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows a schematic side view (not to scale) of the major components of the inventive guidewire.

FIG. 2 is a partial cutaway, side view of composite guidewire according to this invention having distal portion of a highly elastic alloy.

FIG. 3 is a partial cutaway side view of one embodiment of the distal tip of the FIG. 1 device.

FIG. 4 is a partial cutaway side view of a second embodiment of the distal tip of the FIG. 1 device.

FIG. 5A is a partial cutaway side view of a third embodiment of the distal tip of the FIG. 1 device.

FIG. 5B is a partial cutaway top view of the embodiment shown in FIG. 5A.

FIG. 6 is a partial side view of a midsection joint in the inventive guidewire.

FIG. 7 shows a typical stress-strain diagram for a Ni-Ti alloy displaying objective criteria for selection of alloys for the inventive guidewire.

DESCRIPTION OF THE INVENTION

FIG. 1 shows an enlarged side view of a guidewire made according to a very desirable variation of the inventive guidewire (100). The guidewire (100) is made up of the wire core formed of a flexible torqueable wire filament material, of the alloys described below, and has a total length typically between about 50 and 300 centimeters. The proximal section (102) preferably has a uniform diameter (along its length) of about 0.010 to 0.025 inches, preferably 0.010 to 0.018 inches. The relatively more flexible distal section (104) extends for 3 to 30 centimeters or more of the distal end of the guidewire (100). There may be a middle section (106) having a diameter intermediate between the diameter of the two portions of the wire adjoining the middle section. The middle section (106) may be continuously tapered, may have a number of tapered sections or sections of differing diameters, or may be of a uniform diameter along its length. If middle section (106) is of a generally uniform diameter, the guidewire core will neck down as is seen at (108). The distal section (104) of the guidewire (100 ) typically has an end cap (110), a fine wire coil (112), and a solder joint (114). The fine wire coil (112) may be radiopaque and made from materials including but not limited to platinum and its alloys. Specific inventive variations of the distal section (104) are described below. The end cap (110) may be radiopaque to allow knowledge of the position of the coil (112) during the process of inserting the catheter and traversal of the guidewire through the vasculature. All or part of the guidewire proximal section (102) and middle section (106) and distal section (104) may be coated with a thin layer (116) of polymeric material to improve its lubricity without adversely affecting the flexibility or shapeability of the guidewire.

FIG. 2 shows a variation of the inventive guidewire which is a composite, e.g., a distal portion of the guidewire core is produced of the specified alloy and the composite is of another material or configuration. In particular, the composite guidewire (140) is made up of a proximal section (142) that is a section of small diameter tubing of, e.g., an appropriate stainless steel or high elasticity alloy such as those discussed elsewhere herein. The tubular proximal section (142) is attached by soldering or by gluing or by other joining method suitable for the materials involved at the joint (144) to a distal section (146) that extends to the distal end of the composite guidewire assembly (140). The distal tip (148) of the catheter assembly (140) may be of the same configuration as those otherwise described herein. The catheter assembly may be coated (150) with polymeric material, as desired.

FIG. 3 shows a partial cutaway of one embodiment of the distal section (104) and the distal end of the intermediate section (106). The metallic guidewire core is shown partially coated with polymer (116) and a malleable metal coating (118) on the tapered portion of the distal tip. The malleable metal may be selected from suitable radiopaque materials such as gold or other easily solderable materials such as silver, platinum, palladium, rhodium, and alloys of the above. The tip also includes a radiopaque coil (112) which is bounded on its proximal end by a solder joint (114) and is joined with the end of the guidewire at (110). The radiopaque coil (112) may be made of known suitable materials such as platinum, palladium, rhodium, silver, gold, and their alloys. Preferred is an alloy containing platinum and a small amount of tungsten. The proximal and distal ends of coil (112) may be secured to the core wire by soldering.

FIG. 4 shows a partial cutaway of another embodiment of the distal section (104) of the inventive guidewire. In this embodiment, the metal guidewire core has a proximal tapered portion (120), a distal tapered section (122) with a solder joint (114) separating the two sections, and a constant diameter tip (124). The distal tip (124) may have constant diameter typically between about 0.002 and 0.005 inches, preferably about 0.003 inches. The distal tip (124) is preferably between about 1 and 5 cm in length, preferably about 2 cm but the portion of constant diameter extends for at least about 25% of the distance between the solder joint (128) and the solder joint (114). This constant diameter section marginally stiffens the distal tip assembly for enhanced control. The entire distal section (104) desirably is between about 20 and 50 cm, preferably about 25 cm in length. The maximum diameter of the proximal tapered portion (120) of the guidewire core typically is between about 0.005 and 0.020 inches, preferably about 0.010 inches. The distal tapered portion (122) and distal tip (124) are again shown with a malleable metal coating (118) such that the distal tapered portion (122) and distal tip (124) stay bent upon forming by the physician. In this embodiment, the fine wire coil (112) is bounded on its proximal end by a solder joint (114) and on its distal end by an end cap (110). The end cap (110) is connected to the guidewire by means of a metallic ribbon (126). The ribbon (126) may be made of stainless steel, platinum, palladium, rhodium, silver, gold, tungsten, and their alloys or other materials which are plastic and that are easily soldered. The ribbon (126) is soldered to the fine wire coil (112) and to the distal tip (124) of the distal section (104) of the guidewire at a solder joint (128) such that the end cap (110) is secured against the fine wire coil (112).

FIGS. 5A and 5B show yet another inventive embodiment of the distal section (104) of the guidewire (100). FIG. 5A shows a side view, partial cutaway of the inventive guidewire. The fine wire coil (112) may be bounded by a polymer adhesive (136) that joins the coil (112) to the core wire and an end cap (110) and further secured to the guidewire core by a solder joint (128). In this embodiment, the distal section (104) of the guidewire again comprises a tapered portion (120) that is proximal to the polymer adhesive (136) and a tapered portion (122) that is distal to the polymer adhesive (136). The distal section (104) also comprises a smaller diameter portion (130) or "neck" that may be surrounded by optional inner coil (132). As may be seen from FIG. 5A, just distal of the neck (130) is a section which is larger in side view than is the neck. As may be seen from FIG. 5A, just distal of the neck (130 ) is a section which is larger in side view than is the neck. The inner coil (132) may be made of a suitable metallic material preferably that is easy to solder and preferably radiopaque. It is preferably platinum or stainless steel. One way to produce neck (130) is to flatten the distal portion of the guidewire (134) distal to the neck so that the resulting spade (134) is no longer of circular cross-section but rather is of rectangular shape. This may be more easily visualized in FIG. 5B since that Figure shows a cutaway top view of the guidewire shown in FIG. 5A. As in above-described embodiments, the end cap (110) is secured to the guidewire by a metallic ribbon (126). The solder joint (128) secures the guidewire core to the inner helical coil (132) which secures the end cap (110) via the ribbon (126) and further secures the outer fine wire coil (112). This configuration is especially valuable for use with guidewire materials which are not easily solderable. The solder joint need not adhere to the guidewire and yet the inner coil (132), ribbon (126), and outer fine wire coil (112) all are maintained as a single integral unit and have no chance of slipping proximally or distally on the guidewire assembly.

Although the embodiment described with reference to FIGS. 5A and 5B speaks generally of a guidewire made of a high elasticity alloy, materials for the guidewire and the ribbon such as stainless steel, platinum, palladium, rhodium and the like are suitable with that embodiment.

FIG. 6 is a partial side view of a midsection joint in the inventive guidewire. On many variations of the inventive guidewire, various sections of the core are joined by tapered sections such as seen at (160). This means that the guidewire core is significantly stiffer at the proximal end of the tapered joint (160). We have found that it is sometimes desirable to place grooves (162) in that proximal end to lower the overall stiffness of the guidewire at that junction and yet retain the columnar strength.

GUIDEWIRE CORE

This guidewire is typically used in a catheter which is made up of an elongate tubular member having proximal and distal ends. The catheter is (again) about 50 to 300 centimeters in length, typically between about 100 and 200 centimeters in length. Often, the catheter tubular member has a relatively stiff proximal section which extends along a major portion of the catheter length and one or more relatively flexible distal sections which provide greater ability of the catheter to track the guidewire through sharp bends and turns encountered as the catheter is advanced through the torturous paths found in the vasculature. The construction of a suitable catheter assembly having differential flexibility along its length is described in U.S. Pat. No. 4,739,768.

We have found that certain alloys, particularly Ni-Ti alloys, retain their super-elastic properties during traversal through the vasculature and yet are sufficiently pliable that they provide the physician using the guidewire with enhanced "feel" or feedback and yet do not "whip" during use. That is to say, as a guidewire is turned it stores energy during as a twist and releases it precipitously as it "whips" to quickly recover the stored stress. The preferred alloys do not incur significant unrecovered strain during use. We have also found that if the eccentricity of the wire, i.e., the deviation of the cross-section of the guidewire from "roundness" (particularly in the middle section) is maintained at a very low value, the guidewire is much easier to steer or direct through the vasculature.

The material used in the guidewires of this invention are of shape memory alloys which exhibit super-elastic/pseudo-elastic shape recovery characteristics. These alloys are known. See, for instance, U.S. Pat. Nos. 3,174,851 and 3,351,463 as well as 3,753,700; however, the '700 patent describes a less desirable material because of the higher modulus of the material due to an increased iron content. These metals are characterized by their ability to be transformed from an austenitic crystal structure to a stress-induced martensitic (SIM) structure at certain temperatures, and return elastically to the austenitic structure when the stress is removed. These alternating crystalline structures provide the alloy with its super-elastic properties. One such well-known alloy, nitinol, is a nickel-titanium alloy. It is readily commercially available and undergoes the austenite-SIM-austenite transformation at a variety of temperature ranges between -20° C. and 30° C.

These alloys are especially suitable because of their capacity to elastically recover almost completely to the initial configuration once the stress is removed. Typically there is little plastic deformation, even at relatively high strains. This allows the guidewire to undertake substantial bends as it passes through the body's vasculature, and yet return to its original shape once the bend has been traversed without retaining any hint of a kink or a bend. However, the tips shown are often sufficiently plastic that the initial tip formation is retained. Nevertheless, compared to similar stainless steel guidewires, less force need be exerted against the interior walls of the vessels to deform the guidewire of the invention along the desired path through the blood vessel thereby decreasing trauma to the interior of the blood vessel and reducing friction against the coaxial catheter.

A guidewire, during its passage through the vasculature to its target site, may undertake numerous bends and loops. The desirably of enhancing the ease with which a guidewire may be twisted to allow the bent distal tip to enter a desired branch of the vasculature cannot be overstated. We have found that a major factor in enhancing such ease of use, that is, in enhancing the controllability of the guidewires is by controlling the eccentricity of the cross-section of the middle portion of the guidewire. We have found that by maintaining the middle portion of the guidewire (106 in FIG. 1) to an eccentricity ratio of 1±10-4, the guidewire is significantly more controllable than those which fall outside this ratio. By "eccentricity", we mean that at any point along the guidewire the ratio of the largest diameter at that cross-section to the smallest diameter of the wire at that cross-section.

To achieve these results of high strength and enhanced control even while allowing feedback to the attending physician during use, we have found that the following physical parameters of the alloy are important. In a stress-strain test as shown on a stress-strain diagram such as that found in FIG. 7, the stress found at the midpoint of the upper plateau (UP) (measured, e.g. at about 3% strain when the test end point is about 6% strain) should be in the range of 75 ksi (thousand pounds per square inch) +10 ksi and, preferably, in the range of 75 ksi±5 ksi. Additionally, this material should exhibit a lower plateau (LP) of 25±7.5 ksi, preferably 20±2.5 ksi, measured at the midpoint of the lower plateau. The material preferably has no more than about 0.25% residual strain (RS) (when stressed to 6% strain and allowed to return) and preferably no more than about 0.15% residual strain.

The preferred material is nominally 50.6%±0.2% Ki and the remainder Ti. The alloy should contain no more than about 500 parts per million of any of O, C, or N. Typically such commercially available materials will be sequentially mixed, cast, formed, and separately co-worked to 30-40%, annealed and stretched.

By way of further explanation, FIG. 7 shows a stylized stress-strain diagram showing the various parameters noted above and their measurement on that diagram. As stress is initially applied to a sample of the material, the strain is at first proportional (a) until the phase change from austentite to martensite begins at (b). At the upper plateau (UP), the energy introduced with the applied stress is stored during the formation of the quasi-stable martensite phase or stress-induced-martensite (SIM). Upon substantial completion of the phase change, the stress-strained relationship again approaches a proportional relationship at (c). The stress is no longer applied when the strain reaches 6%. The measured value (UP) is found at the midpoint between zero and 6% strain, i.e., at 3% strain. If another terminal condition of strain is chosen, e.g., 7%, the measured valued of (UP) and (LP) would be found at 3.5%.

Materials having high UP values produce guidewires which are quite strong and allow exceptional torque transmission but cause a compromise in the resulting "straightness" of the guidewire. We have found that guidewires having high UP values in conjunction with high LP values are not straight. These guidewires are difficult to use because of their tendency to "whip" as they are turned. Again, that is to say, as a guidewire is turned it stores energy during as a twist and releases it quickly. The difficulty of using such a whipping guidewire should be apparent. Materials having UP values as noted above are suitable as guidewires.

Furthermore, materials having values of LP which are high, again, are not straight. Lowering the value of LP compromises the ability of the guidewire to transmit torque but improves the ease with which a straight guidewire may be produced. Lowering the LP value too far, however, results in a guidewire which, although round, has poor tactile response. It feels somewhat "vague" and "soupy" during its use. The LP values provided for above allow excellent torque transmission, straightness, and the valuable tactile response.

The values of residual strain discussed above define a materials which do not kink or otherwise retain a "set" or configuration after stress during use as a guidewire.

EXAMPLE

In each instance, the following procedure was used in producing the data displayed in the table which follows: commercial Ni-Ti alloy wires having a nominal composition of 50.6% Ni and the remainder Ti, and diameters of 0.13", 0.16", or 0.18" were stressed at room temperature. In each instance, values for transition temperature, PS, UP, and LP were measured. Additionally, several of the noted wires were introduced into a U-shaped Tygon tube and spun to allow qualitative evaluation of the roundness and tactile response of the wires. Comments on that response are also found in the following table.

              TABLE______________________________________    Comparative/     Invention              UP     LP                           PS                                A*                                             Qualitative#     (C/I)          (ksi)                  (ksi)                         (%)                               T ° C.                                   Spin Test______________________________________1.sup.1    I          74.48  31.45                      0.06  -11   Smooth rotation,                                   good feel2.sup.2     I         76.94                   18.90                       0.121                             -8      Smooth rotation,                                   good feel3.sup.3     I         71.92                   24.06                         0.10                              13.5                                      Smooth4.sup.4     C         78.24                   58.82                         0.20                              -9     Very rough                                   turning, whipped5.sup.5     C         63.80                   13.25                         0.2                               12.5                                      Smooth turning,                                   mushy feel6.sup.6     C         58.30                   13.31                         0.0                               -12                                    Turned roughly,                                   mushy feel7.sup.7     C          --                   --     --                              --      Difficult to______________________________________                                  turn .sup.1 Commercially available from U.S. Nitinol, Inc. .sup.2 Commercially available from Special Metals, Inc. .sup.3 Commercially available from Shape Metal Alloys, Inc. .sup.4 Commercially available as a plastic coated 0.13"  guidewire from Fuji Terumo, Inc. .sup.5 Commercially available from ITI. .sup.6 Commercially available from Metal Tek .sup.7 Stainless Steel *Measured at room temperature with no applied stress.

These data describe both guidewires made according to the invention and comparative guidewires. Additionally, they show that guidewire made from a typical stainless steel alloy is very difficult to turn using the qualitative test described above.

GUIDEWIRE CORE COATINGS

As mentioned above, all or part of the guidewire core may be covered or coated with one or more layers of a polymeric material. The coating is applied typically to enhance the lubricity of the guidewire core during its traversal of the catheter lumen or the vascular walls.

Coating Materials

As noted above, at least a portion of the guidewire core may simply be coated by dipping or spraying or by similar process with such materials as polysulfones, polyfluorocarbons (such as TEFLON), polyolefins such as polyethylene, polypropylene, polyesters (including polyamides such as the NYLON's), and polyurethanes; their blends and copolymers such as polyether block amides (e.g., PEBAX).

It is often desirable to utilize a coating such as discussed just above on the proximal portion of the guidewire and a coating such as discussed below on the more distal sections. Any mixture of coatings placed variously on the guidewire is acceptable as chosen for the task at hand.

The guidewire core may also be at least partially covered with other hydrophilic polymers including those made from monomers such as ethylene oxide and its higher homologs; 2-vinyl pyridine; N-vinylpyrrolidone; polyethylene glycol acrylates such as mono-alkoxy polyethylene glycol mono(meth) acrylates, including mono-methoxy triethylene glycol mono (meth) acrylate, mono-methoxy tetraethylene glycol mono (meth) acrylate, polyethylene glycol mono (meth) acrylate; other hydrophilic acrylates such as 2-hydroxyethylmethacrylate, glycerylmethacrylate; acrylic acid and its salts; acrylamide and acrylonitrile; acrylamidomethylpropane sulfonic acid and its salts cellulose, cellulose derivatives such as methyl cellulose ethyl cellulose, carboxymethyl cellulose, cyanoethyl cellulose, cellulose acetate, polysaccharides such as amylose, pectin, amylopectin, alginic acid, and cross-linked heparin; maleic anhydride; aldehydes. These monomers may be formed into homopolymers or block or random copolymers. The use of oligomers of these monomers in coating the guidewire for further polymerization is also an alternative. Preferred precursors include ethylene oxide; 2-vinyl pyridine; N-vinylpyrrolidone and acrylic acid and its salts; acrylamide and acrylonitrile polymerized (with or without substantial crosslinking) into homopolymers, or into random or block copolymers.

Additionally, hydrophobic monomers may be included in the coating polymeric material in an amount up to about 30% by weight of the resulting copolymer so long as the hydrophilic nature of the resulting copolymer is not substantially compromised. Suitable monomers include ethylene, propylene, styrene, styrene derivatives, alkylmethacrylates, vinylchloride, vinylidenechloride, methacrylonitrile, and vinyl acetate. Preferred are ethylene, propylene, styrene, and styrene derivatives.

The polymeric coating may be cross-linked using various techniques, e.g., by light such as ultraviolet light, heat, or ionizing radiation, or by peroxides or azo compounds-such as acetyl peroxide, cumyl peroxide, propionyl peroxide, benzoyl peroxide, or the like. A polyfunctional monomer such as divinylbenzene, ethylene glycol dimethacrylate, trimethylolpropane, pentaerythritol di- (or tri- or tetra-) methacrylate, diethylene glycol, or polyethylene glycol dimethacrylate, and similar multifunctional monomers capable of linking the monomers and polymers discussed above.

Polymers or oligomers applied using the procedure described below are activated or functionalized with photoactive or radiation-active groups to permit reaction of the polymers or oligomers with the underlying polymeric surface. Suitable activation groups include benzophenone, thioxanthone, and the like; acetophenone and its derivatives specified as:

Ph

C═O

R.sup.1 --C--R.sup.3

R.sup.2

where

R1 is H, R2 is OH, R3 is Ph; or

R1 is H, R2 is an alkoxy group including--OCH3, --OC2 H3, R3 is Ph; or

R1 =R2 =an alkoxy group, R3 is Ph; or

R1 =R2 =an alkoxy group, R3 is H; or

R1 =R2 =Cl, R3 is H or Cl.

Other known activators are suitable.

The polymeric coating may then be linked 25 with the substrate using known and appropriate techniques selected on the basis of the chosen activators, e.g., by ultraviolet light, heat, or ionizing radiation. Crosslinking with the listed polymers or oligomers may be accomplished by use of peroxides or azo compounds such as acetyl peroxide, cumyl peroxide, propionyl peroxide, benzoyl peroxide, or the like. A polyfunctional monomer such as divinylbenzene, ethylene glycol dimethacrylate, trimethylolpropane, pentaerythritol di- (or tri- or tetra-) methacrylate, diethylene glycol, or polyethylene glycol dimethacrylate, and similar multifunctional monomers capable of linking the polymers and oligomers discussed above is also appropriate for this invention.

The polymeric coating may be applied to the guidewire by any of a variety of methods, e.g., by spraying a solution or suspension of the polymers or of oligomers of the monomers onto the guidewire core or by dipping it into the solution or suspension. Initiators may be included in the solution or applied in a separate step. The guidewire may be sequentially or simultaneously dried to remove solvent after application of the polymer or oligomer to the guidewire and crosslinked.

The solution or suspension should be very dilute since only a very thin layer of polymer is to be applied. We have found that an amount of oligomer or polymer in a solvent of between 0.25% and 5.0% (wt), preferred is 0.5 to 2.0% (wt), is excellent for thin and complete coverage of the resulting polymer. Preferred solvents for this procedure when using the preferred polymers and procedure are water, low molecular weight alcohols, and ethers, especially methanol, propanol, isopropanol, ethanol, and their mixtures. Other water miscible solvents, e.g., tetrahydrofuran, methylene dichloride, methylethylketone, dimethylacetate, ethyl acetate, etc., are suitable for the listed polymers and must be chosen according to the characteristics of the polymer; they should be polar because of the hydrophilic nature of the polymers and oligomers but, because of the reactivity of the terminal groups of those materials, known quenching effects caused by oxygen, hydroxyl groups and the like must be recognized by the user of this process when choosing polymers and solvent systems.

Particularly preferred as a coating for the guidewire cores discussed herein are physical mixtures of homo-oligomers of at least one of polyethylene oxide; poly-2-vinyl pyridine; polyvinylpyrrolidone, polyacrylic acid, polyacrylamide, and polyacrylonitrile. The catheter bodies or substrates are preferably sprayed or dipped, dried, and irradiated to produce a polymerized and crosslinked polymeric skin of the noted oligomers.

The lubricious hydrophilic coating is preferably produced using generally simultaneous solvent removal and crosslinking operations. The coating is applied at a rate allowing "sheeting" of the solution, e.g., formation of a visibly smooth layer without "runs". In a dipping operation for use with most polymeric substrates including those noted below, the optimum coating rates are found at a linear removal rate between 0.25 and 2.0 inches/sec, preferably 0.5 and 1.0 inches/sec.

The solvent evaporation operations may be conducted using a heating chamber suitable for maintaining the surface at a temperature between 25° C. and the glass transition temperature (Tg) of the underlying substrate. Preferred temperatures are 50° C. to 125° C. Most preferred for the noted and preferred solvent systems is the range of 75° to 110° C.

Ultraviolet light sources may be used to crosslink the polymer precursors onto the substrate. Movement through an irradiation chamber having an ultraviolet light source at 90-375 nm (preferably 300-350 nm) having an irradiation density of 50-300 mW/cm2 (preferably 150-250 mW/cm2) for a period of three to seven seconds is desired. Passage of a guidewire core through the chamber at a rate of 0.25 to 2.0 inches/second (0.5 to 1.0 inches/second) in a chamber having three to nine inches length is suitable. When using ionizing radiation, a radiation density of 1 to 100 kRads/cm2 (preferably 20 to 50 kRads/cm2) may be applied to the solution or suspension on the polymeric substrate.

Exceptional durability of the resulting coating is produced by repetition of the dipping/solvent removal/irradiation steps up to five times. Preferred are two to four repetitions.

Tie Layers

We have found that it is often desirable to incorporate a "tie" layer as a coating between the outer polymeric surface and the guidewire core to enhance the overall adhesion of the outer polymeric surface to the core. Of course, these materials must be able to tolerate the various other solvents, cleaners, sterilization procedures, etc. to which the guidewire and its components are placed during other production steps.

Choice of materials for such tie layers is determined through their functionality. Specifically, the materials are chosen for their affinity or tenacity to the outer polymeric lubricious or hydrophilic coating. Clearly, the tie layer material must be flexible and strong. The material must be extrudable and preferably easily made into shrinkable tubing for mounting onto the guidewire through heating. We have found that various NYLON's, polyethylene, polystyrene, polyurethane, and preferably polyethylene terephthalate (PET) make excellent tie layers. These tubing materials may be also formulated to include radio opaque materials such as barium sulfate, bismuth trioxide, bismuth carbonate, tungsten, tantalum or the like.

As noted above, one readily achievable manner of applying a tie layer is by heat-shrinking the tubing onto the guidewire. The guidewire core is simply inserted into a tubing of suitable size--often with a small amount of a "caulking" it either end to seal the tubing from incursion of fluids or unsterile materials from beneath the tubing. The tubing is cut to length and heated until it is sufficiently small in size. The resulting tubing tie layer desirably is between about 0.0025 and 0.015 inches in thickness. The thinner layers are typically produced from polyurethane or PET. The layer of lubricious polymer is then placed on the outer surface of the shrunk tubing.

Another procedure for preparing or pretreating guidewires prior to receiving a subsequent coating of a polymer, preferably a polymer which is lubricious, biocompatible, and hydrophilic, is via the use of a plasma stream to deposit a hydrocarbon or fluorocarbon residue. The procedure is described as follows: the guidewire core is placed in a plasma chamber and cleaned with an oxygen plasma etch. The guidewire core is then exposed to a hydrocarbon plasma to deposit a plasma-polymerized tie layer on the guidewire core to complete the pretreatment. The hydrocarbon plasma may comprise a lower molecular weight (or gaseous) alkanes such as methane, ethane, propane, isobutane, butane or the like; lower molecular weight alkenes such as ethene, propene, isobutene, butene or the like or; gaseous fluorocarbons such as tetrafluoromethane, trichlorofluoromethane, dichlorodifluoromethane, trifluorochloromethane, tetrafluoroethylene, trichlorofluoroethylene, dichlorodifluoroethylene, trifluorochloroethylene and other such materials. Mixtures of these materials are also acceptable. The tie layer apparently provides C--C bonds for subsequent covalent bonding to the outer hydrophilic polymer coating. Preferred flow rates for the hydrocarbon into the plasma chamber are in the range of 500 c.c./min. to 2000 c.c./min. and the residence-time of the guidewire in the chamber is in the range of 1-20 minutes, depending on the chosen hydrocarbon and the plasma chamber operating parameters. Power settings for the plasma chamber are preferably in the range of 200 W to 1500 W.

A tie layer of plasma-produced hydrocarbon residue having a thickness on the order of 10 Å thick is disposed between core and coating. This process typically produces layers of hydrocarbon residue less than about 100 Å in thickness, and more typically less than about 100Å. Tie layer effectively bonds the outer layer to the guidewire core while adding very little additional bulk to the guidewire. Guidewires made according to this invention therefore avoid the size and maneuverability problems of prior art guidewires.

The pretreated guidewire may be coated by a polymer using a procedure such as described above. For example, the pretreated guidewire may be dipped in a solution of a photoactive hydrophilic polymer system, i.e., a latently photoreactive binder group covalently bonded to a hydrophilic polymer. After drying, the coated guidewire is cured by exposing it to UV light. The UV light activates the latently reactive group in the photoactive polymer system to form covalent bonds with crosslinked C--C bonds in the hydrocarbon residue tie layer. The dipping and curing steps are preferably repeated often enough, typically twice, to achieve the appropriate thickness of the hydrophilic coating layer.

One highly preferred variation of the invention involves a guidewire with metal core, preferably 0.010 to 0.025" thick stainless steel or nitinol. The exterior surface of guidewire is a biocompatible coating of a polyacrylamide/polyvinylpyrrolidone mixture bonded to a photoactive binding agent. The preferred coating is made from a mixture of Bio-Metric Systems PA03 and PV05 (or PV01) binding systems according to the Examples below.

The photoactive hydrophilic polymer system of this preferred embodiment is a mixture of Bio-Metric Systems PA03 polyacrylamide/binder system and Bio-Metric Systems PV05 polyvinylpyrrolidone system. The polyacrylamide system provides lubricity, and the polyvinylpyrrolidone system provides both lubricity and binding for durability. The exact proportions of the two systems may be varied to suit the application. As an alternative, however, the hydrophilic biocompatible coating may be polyacrylamide alone, polyvinylpyrrolidone alone, polyethylene oxide, or any suitable coating known in the art. In addition, a coating of heparin, albumin or other proteins may deposited over the hydrophilic coating in a manner known in the art to provide additional biocompatibility features.

The guidewire or other device may be cleaned by using an argon plasma etch in place of the oxygen plasma etch. The thickness of the plasma-polymerized tie layer may also vary without departing from the scope of this invention.

The following examples are further illustrative of the articles and methods of this invention. The invention is not limited to these examples.

EXAMPLE

A 0.016" diameter nitinol guidewire was placed in a Plasma Etch MK II plasma chamber and cleaned with an oxygen plasma for 10 minutes. Methane flowing at a rate of 2000 c.c./min. was admitted into the chamber, and the chamber operated at a power setting of 400 W for 2 minutes to deposit a hydrocarbonaceous residue onto the surface of the wire. All but approximately six inches of the wire was dipped in a polyvinylpyrrolidone/polyacrylamide (PVP/PA) photocrosslinkable solution of a mixture of 67% BSI PV01 and 33% BSI PA03. The coated guidewire was then dried and exposed to an ultraviolet light (325 nm.) for 8 seconds. The dipping, drying, and exposing steps were repeated twice. When wetted, the resulting wire felt lubricious and required less force to pull through an 0.018" ID catheter than an uncoated wire.

EXAMPLE

A 0.016" diameter nitinol guidewire was placed in a Plasma Etch MK II plasma chamber and cleaned with an oxygen plasma for 10 minutes. Methane flowing at a rate of 1500 c.c./min. was admitted into the chamber, and the chamber was operated at a power setting of 600 W for 5 minutes to plasma-treat the methane into a hydrocarbonaceous residue on the surface of the wire. All but approximately six inches of the wire was dipped in a polyvinylpyrrolidone/polyacrylamide (PVP/PA) photocrosslinkable solution consisting essentially a mixture of 50% BSI PV01 and 50% BSI PA03. The coated guidewire was then dried and exposed to an ultraviolet light (325 nm.) for 8 seconds. The dipping, drying, and exposing steps were repeated. When wetted, the resulting wire felt lubricious and required less force to pull through an 0.018" ID catheter than an uncoated wire.

EXAMPLE

A 0.016" diameter nitinol guidewire was placed in a Plasma Etch MK II plasma chamber and cleaned with an oxygen plasma for 10 minutes. Ethane flowing at a rate of 900 c.c./min. was admitted into the chamber, and the chamber was operated at a power setting of 600 W for 10 minutes to deposit a hydrocarbon residue onto the surface of the wire. All but approximately six inches of the wire was dipped in a polyvinylpyrrolidone/polyacrylamide (PVP/PA) photocrosslinkable solution of a mixture of 33% BSI PV01 and 67% BSI PA03. The coated guidewire was then dried and exposed to an ultraviolet light (325 nm.) for 8 seconds. The dipping, drying, and exposing steps were repeated twice. When wetted, the resulting wire felt lubricious and required less force to pull through an 0.01811 ID catheter than an uncoated wire.

Although preferred embodiments of the present invention have been described, it should be understood that various changes, adaptations, and modifications may be made therein without departing from the spirit of the invention and the scope of the claims which follow.

Citas de patentes
Patente citada Fecha de presentación Fecha de publicación Solicitante Título
US33911 *10 Dic 1861 Henry weissenboen
US2221138 *15 Jun 193812 Nov 1940Hendrickson Floyd CFiliform guide
US2279297 *13 Nov 194014 Abr 1942Edwin & Louis Bry IncKnop yarn and method of making the same
US2905178 *19 Dic 195622 Sep 1959Hilzinger Iii PaulSurgical control device for controlling operating means inserted into a body cavity
US3174851 *1 Dic 196123 Mar 1965Buehler William JNickel-base alloys
US3338046 *23 Dic 196629 Ago 1967Cable Covers LtdLooped wire rope or cable
US3351463 *20 Ago 19657 Nov 1967Buehler William JHigh strength nickel-base alloys
US3416531 *2 Ene 196417 Dic 1968Edwards Miles LowellCatheter
US3452742 *29 Jun 19661 Jul 1969Us Catheter & Instr CorpControlled vascular curvable spring guide
US3528406 *29 Oct 196515 Sep 1970Us Catheter & Instr CorpFlexible spring guide tip for insertion of vascular catheters
US3547103 *29 Oct 196515 Dic 1970William A CookCoil spring guide
US3552384 *3 Jul 19675 Ene 1971American Hospital Supply CorpControllable tip guide body and catheter
US3753700 *2 Jul 197021 Ago 1973Raychem CorpHeat recoverable alloy
US3757768 *7 Abr 197211 Sep 1973Medical Evaluation Devices AndManipulable spring guide-catheter and tube for intravenous feeding
US3789841 *15 Sep 19715 Feb 1974Becton Dickinson CoDisposable guide wire
US3890977 *1 Mar 197424 Jun 1975Bruce C WilsonKinetic memory electrodes, catheters and cannulae
US3941119 *19 Jul 19742 Mar 1976Mario CorralesMeans for introducing and guiding objects into body cavities and blood vessels
US3973556 *20 Jun 197510 Ago 1976Lake Region Manufacturing Company, Inc.Smoothened coil spring wire guide
US4003369 *22 Abr 197518 Ene 1977Medrad, Inc.Angiographic guidewire with safety core wire
US4020829 *23 Oct 19753 May 1977Willson James K VSpring guide wire with torque control for catheterization of blood vessels and method of using same
US4178810 *9 Ago 197718 Dic 1979Nagashige TakahashiApparatus for manipulating a medical instrument
US4215703 *29 Ago 19785 Ago 1980Willson James K VVariable stiffness guide wire
US4430083 *6 Mar 19817 Feb 1984American Hospital Supply CorporationInfusion catheter
US4538622 *10 Nov 19833 Sep 1985Advanced Cardiovascular Systems, Inc.Guide wire for catheters
US4545390 *22 Sep 19828 Oct 1985C. R. Bard, Inc.Steerable guide wire for balloon dilatation procedure
US4554929 *13 Jul 198326 Nov 1985Advanced Cardiovascular Systems, Inc.Catheter guide wire with short spring tip and method of using the same
US4619274 *18 Abr 198528 Oct 1986Advanced Cardiovascular Systems, Inc.Torsional guide wire with attenuated diameter
US4665906 *21 May 198619 May 1987Raychem CorporationMedical devices incorporating sim alloy elements
US4721117 *25 Abr 198626 Ene 1988Advanced Cardiovascular Systems, Inc.Torsionally stabilized guide wire with outer jacket
US4739768 *2 Jun 198626 Abr 1988Target TherapeuticsCatheter for guide-wire tracking
US4770188 *18 May 198213 Sep 1988Machida Endoscope Co., Ltd.Guide tube assembly for an endoscope
US4790624 *31 Oct 198613 Dic 1988Identechs CorporationMethod and apparatus for spatially orienting movable members using shape memory effect alloy actuator
US4846186 *12 Ene 198811 Jul 1989Cordis CorporationFlexible guidewire
US4925445 *9 Feb 198915 May 1990Fuji Terumo Co., Ltd.Guide wire for catheter
US4934380 *23 Nov 198819 Jun 1990Boston Scientific CorporationMedical guidewire
US4966163 *14 Feb 198930 Oct 1990Advanced Cardiovascular Systems, Inc.Extendable guidewire for vascular procedures
US4969890 *7 Jul 198813 Nov 1990Nippon Zeon Co., Ltd.Catheter
US4971490 *19 Sep 198920 Nov 1990National Standard CompanyFlexible guide wire with improved mounting arrangement for coil spring tip
US4984581 *12 Oct 198815 Ene 1991Flexmedics CorporationFlexible guide having two-way shape memory alloy
US4991602 *27 Jun 198912 Feb 1991Flexmedics CorporationFlexible guide wire with safety tip
US4998923 *23 Dic 198812 Mar 1991Advanced Cardiovascular Systems, Inc.Steerable dilatation catheter
US5019040 *31 Ago 198928 May 1991Koshin Sangyo Kabushiki KaishaCatheter
US5042985 *11 May 198927 Ago 1991Advanced Cardiovascular Systems, Inc.Dilatation catheter suitable for peripheral arteries
US5050606 *25 May 199024 Sep 1991Advanced Cardiovascular Systems, Inc.Method for measuring pressure within a patient's coronary artery
US5069226 *27 Abr 19903 Dic 1991Tokin CorporationCatheter guidewire with pseudo elastic shape memory alloy
US5095915 *19 Mar 199017 Mar 1992Target TherapeuticsGuidewire with flexible distal tip
US5111829 *18 Ene 199112 May 1992Boston Scientific CorporationSteerable highly elongated guidewire
US5120308 *3 May 19899 Jun 1992Progressive Angioplasty Systems, Inc.Catheter with high tactile guide wire
US5129890 *1 Feb 199114 Jul 1992Cook IncorporatedHydrophilically coated flexible wire guide
US5143085 *1 Oct 19901 Sep 1992Wilson Bruce CSteerable memory alloy guide wires
US5144959 *15 Ago 19898 Sep 1992C. R. Bard, Inc.Catheter guidewire with varying radiopacity
US5171383 *16 Sep 199115 Dic 1992Terumo Kabushiki KaishaMethod of manufacturing a differentially heat treated catheter guide wire
US5213111 *10 Jul 199125 May 1993Cook IncorporatedComposite wire guide construction
US5230348 *11 Oct 199127 Jul 1993Nippon Seisen Co., Ltd.Guide wire for a catheter
US5238004 *30 Sep 199224 Ago 1993Boston Scientific CorporationHigh elongation linear elastic guidewire
US5341818 *22 Dic 199230 Ago 1994Advanced Cardiovascular Systems, Inc.Guidewire with superelastic distal portion
US5409015 *11 May 199325 Abr 1995Target Therapeutics, Inc.Deformable tip super elastic guidewire
US5429139 *7 Mar 19944 Jul 1995Schneider (Europe) A.G.Guide wire
EP0014424A1 *29 Ene 198020 Ago 1980Toray Monofilament Company LimitedMedical vascular guide wire and self-guiding type catheter
EP0382974A1 *4 Dic 198922 Ago 1990C.R. Bard, Inc.Braided guide wire and method for the use thereof
EP0491349A2 *17 Dic 199124 Jun 1992Advanced Cardiovascular Systems, Inc.Superelastic guiding member
EP0515201A1 *21 May 199225 Nov 1992C.R. Bard, Inc.Superelastic formable guidewire
EP0519604A2 *20 May 199223 Dic 1992Scimed Life Systems, Inc.Intravascular guide wire and method of manufacture thereof
WO1991015152A1 *9 Abr 199117 Oct 1991Boston Scientific CorporationHigh elongation linear elastic guidewire
WO1992014506A1 *14 Feb 19923 Sep 1992Raychem CorporationSteerable cannula
Citada por
Patente citante Fecha de presentación Fecha de publicación Solicitante Título
US625455019 Ago 19993 Jul 2001Cook IncorporatedPreformed wire guide
US645102613 Dic 200017 Sep 2002Advanced Cardiovascular Systems, Inc.Dock exchange system for composite guidewires
US657592030 May 200110 Jun 2003Scimed Life Systems, Inc.Distal tip portion for a guide wire
US66525089 Nov 200125 Nov 2003Scimed Life Systems, Inc.Intravascular microcatheter having hypotube proximal shaft with transition
US66824933 Dic 200127 Ene 2004Scimed Life Systems, Inc.High torque guidewire
US700136927 Mar 200321 Feb 2006Scimed Life Systems, Inc.Medical device
US702208621 May 20024 Abr 2006Scimed Life Systems, Inc.Guidewire with encapsulated marker
US70449213 Feb 200316 May 2006Scimed Life Systems, IncMedical device with changeable tip flexibility
US70637076 Mar 200320 Jun 2006Scimed Life Systems, Inc.Medical retrieval device
US707781123 Dic 200218 Jul 2006Scimed Life Systems, Inc.Guidewire tip construction
US71532773 Dic 200226 Dic 2006Scimed Life Systems, Inc.Composite medical device with markers
US718273526 Feb 200327 Feb 2007Scimed Life Systems, Inc.Elongated intracorporal medical device
US72373135 Dic 20033 Jul 2007Boston Scientific Scimed, Inc.Elongated medical device for intracorporal use
US731665610 Dic 20038 Ene 2008Boston Scientific Scimed, Inc.Elongated intracorporal medical device
US731669212 Ago 20038 Ene 2008Boston Scientific Scimed, Inc.Laser-cut clot puller
US734455021 Oct 200318 Mar 2008Boston Scientific Scimed, Inc.Clot removal device
US741653422 Jun 200426 Ago 2008Boston Scientific Scimed, Inc.Medical device including actuator
US748833827 Dic 200110 Feb 2009Boston Scientific Scimed, Inc.Catheter having an improved torque transmitting shaft
US755328730 Oct 200330 Jun 2009Boston Scientific Scimed, Inc.Guidewire having an embedded matrix polymer
US759508230 Mar 200429 Sep 2009Cook IncorporatedWire guide
US761837930 Dic 200517 Nov 2009Boston Scientific Scimed, Inc.Composite guidewire
US764162125 Ago 20035 Ene 2010Boston Scientific Scimed, Inc.Elongated intra-lumenal medical device
US764164729 Dic 20035 Ene 2010Boston Scientific Scimed, Inc.Medical device with modified marker band
US76515788 Jun 200626 Ene 2010Boston Scientific Scimed, Inc.Guidewire with polymer jacket and method of making
US767030218 Dic 20012 Mar 2010Boston Scientific Scimed, Inc.Super elastic guidewire with shape retention tip
US7687144 *20 Feb 200430 Mar 2010Wilson-Cook Medical, Inc.Medical device with adherent coating, and method for preparing same
US773169313 Oct 20068 Jun 2010Cook IncorporatedCoupling wire guide
US774457416 Dic 200429 Jun 2010Boston Scientific Scimed, Inc.Catheter tip to reduce wire lock
US774458722 Sep 200329 Jun 2010Boston Scientific Scimed, Inc.Surface modified reinforcing member for medical device and method for making same
US774731430 Dic 200329 Jun 2010Boston Scientific Scimed, Inc.Distal assembly for a medical device
US77540478 Abr 200413 Jul 2010Boston Scientific Scimed, Inc.Cutting balloon catheter and method for blade mounting
US775852027 May 200320 Jul 2010Boston Scientific Scimed, Inc.Medical device having segmented construction
US775856513 Oct 200620 Jul 2010Cook IncorporatedIdentifiable wire guide
US775860429 May 200320 Jul 2010Boston Scientific Scimed, Inc.Cutting balloon catheter with improved balloon configuration
US776307724 Dic 200327 Jul 2010Biomerix CorporationRepair of spinal annular defects and annulo-nucleoplasty regeneration
US77806268 Ago 200324 Ago 2010Boston Scientific Scimed, Inc.Catheter shaft for regulation of inflation and deflation
US778527322 Sep 200331 Ago 2010Boston Scientific Scimed, Inc.Guidewire with reinforcing member
US778527529 Ene 200731 Ago 2010Cook IncorporatedWire guide having distal coupling tip
US779898029 Ene 200721 Sep 2010Cook IncorporatedWire guide having distal coupling tip for attachment to a previously introduced wire guide
US780339517 May 200428 Sep 2010Biomerix CorporationReticulated elastomeric matrices, their manufacture and use in implantable devices
US781123811 Ene 200712 Oct 2010Cook IncorporatedWire guide having distal coupling tip
US782434522 Dic 20032 Nov 2010Boston Scientific Scimed, Inc.Medical device with push force limiter
US782439220 Ago 20032 Nov 2010Boston Scientific Scimed, Inc.Catheter with thin-walled braid
US783356424 Ago 200616 Nov 2010Boston Scientific Scimed, Inc.Elongate medical device and method of coating the same
US78419942 Nov 200730 Nov 2010Boston Scientific Scimed, Inc.Medical device for crossing an occlusion in a vessel
US785062327 Oct 200514 Dic 2010Boston Scientific Scimed, Inc.Elongate medical device with continuous reinforcement member
US787898425 Jul 20031 Feb 2011Boston Scientific Scimed, Inc.Medical device for navigation through anatomy and method of making same
US788752919 Abr 200415 Feb 2011Boston Scientific Scimed, Inc.Hybrid micro guide catheter
US788755714 Ago 200315 Feb 2011Boston Scientific Scimed, Inc.Catheter having a cutting balloon including multiple cavities or multiple channels
US789218720 Jul 200722 Feb 2011Terumo Kabushiki KaishaGuide wire
US790136727 Jun 20068 Mar 2011Cook IncorporatedWire guide advancement system
US79144665 Ago 200329 Mar 2011Precision Vascular Systems, Inc.Medical device with collapse-resistant liner and method of making same
US79144678 Ago 200729 Mar 2011Boston Scientific Scimed, Inc.Tubular member having tapered transition for use in a medical device
US79226737 Ago 200312 Abr 2011Terumo Kabushiki KaishaGuide wire
US795109313 Dic 200631 May 2011Boston Scientific Scimed, Inc.Composite medical device with markers
US795534516 Feb 20067 Jun 2011Nexgen Medical Systems, Inc.Thrombus removal system and process
US7993285 *5 Nov 20029 Ago 2011Boston Scientific Scimed, Inc.Medical device having flexible distal tip
US799328631 Ene 20079 Ago 2011Boston Scientific Scimed, Inc.Composite guidewire
US799335824 Mar 20099 Ago 2011Boston Scientific Scimed, Inc.Cutting balloon catheter having increased flexibility regions
US799816528 Nov 200716 Ago 2011Stryker CorporationLaser-cut clot puller
US800271530 May 200823 Ago 2011Boston Scientific Scimed, Inc.Medical device including a polymer sleeve and a coil wound into the polymer sleeve
US80213297 Dic 200920 Sep 2011Boston Scientific Scimed, Inc.,Catheter including a compliant balloon
US802233115 Ene 200720 Sep 2011Boston Scientific Scimed, Inc.Method of making elongated medical devices
US803869112 Nov 200418 Oct 2011Boston Scientific Scimed, Inc.Cutting balloon catheter having flexible atherotomes
US804800431 Jul 20071 Nov 2011Precision Vascular Systems, Inc.Medical device for navigation through anatomy and method of making same
US804806016 Ago 20061 Nov 2011Boston Scientific Scimed, Inc.Medical device
US807549722 Ago 200613 Dic 2011Cook Medical Technologies LlcWire guide having distal coupling tip
US808000030 Oct 200720 Dic 2011Acclarent, Inc.Methods and apparatus for treating disorders of the ear nose and throat
US808810126 Oct 20073 Ene 2012Acclarent, Inc.Devices, systems and methods for treating disorders of the ear, nose and throat
US809043330 Oct 20073 Ene 2012Acclarent, Inc.Methods and apparatus for treating disorders of the ear nose and throat
US81009338 May 200824 Ene 2012Acclarent, Inc.Method for treating obstructed paranasal frontal sinuses
US81052463 Ago 200731 Ene 2012Boston Scientific Scimed, Inc.Elongate medical device having enhanced torque and methods thereof
US810988720 Jul 20077 Feb 2012Terumo Kabushiki KaishaGuide wire
US811391617 Ene 200314 Feb 2012Boston Scientific Scimed, Inc.Straightening and centerless grinding of wire for use with medical devices
US81140621 Oct 200914 Feb 2012Acclarent, Inc.Devices and methods for delivering therapeutic substances for the treatment of sinusitis and other disorders
US81141134 Oct 200514 Feb 2012Acclarent, Inc.Multi-conduit balloon catheter
US811875730 Abr 200721 Feb 2012Acclarent, Inc.Methods and devices for ostium measurement
US811882924 Ene 200821 Feb 2012Stryker CorporationClot removal device
US812372229 Oct 200728 Feb 2012Acclarent, Inc.Devices, systems and methods for treating disorders of the ear, nose and throat
US812416726 Mar 201028 Feb 2012Cook Medical Technologies LlcMedical device with adherent coating, and method for preparing same
US812490530 Abr 200728 Feb 2012Terumo Kabushiki KaishaGuide wire
US81285792 Nov 20076 Mar 2012Boston Scientific Scimed, Inc.Guidewires with improved fatigue life and methods of making the same
US813319014 Jun 200713 Mar 2012Cook Medical Technologies LlcWeldable wire guide with distal coupling tip
US813319927 Ago 200813 Mar 2012Boston Scientific Scimed, Inc.Electroactive polymer activation system for a medical device
US813729113 Oct 200620 Mar 2012Cook Medical Technologies LlcWire guide having distal coupling tip
US813729227 Jun 200720 Mar 2012Boston Scientific Scimed, Inc.Elongated medical device for intracorporal use
US813729317 Nov 200920 Mar 2012Boston Scientific Scimed, Inc.Guidewires including a porous nickel-titanium alloy
US81424224 Mar 200827 Mar 2012Acclarent, Inc.Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, nose and/or throat
US814640031 Jul 20073 Abr 2012Acclarent, Inc.Endoscopic methods and devices for transnasal procedures
US81527421 May 200610 Abr 2012Boston Scientific Scimed, Inc.Crossing guide wire with corrugated shaping ribbon
US815776610 Feb 200917 Abr 2012Medrad, Inc.Torqueable kink-resistant guidewire
US816782126 Feb 20031 May 2012Boston Scientific Scimed, Inc.Multiple diameter guidewire
US817282830 Oct 20078 May 2012Acclarent, Inc.Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures
US817286415 Dic 20098 May 2012Boston Scientific Scimed, Inc.Balloon catheter with improved pushability
US818243210 Mar 200822 May 2012Acclarent, Inc.Corewire design and construction for medical devices
US818246521 May 200922 May 2012Boston Scientific Scimed, Inc.Medical device
US8187433 *3 Oct 200629 May 2012Isense CorporationCompound material analyte sensor
US819038917 May 200629 May 2012Acclarent, Inc.Adapter for attaching electromagnetic image guidance components to a medical device
US822256615 Feb 200517 Jul 2012Boston Scientific Scimed, Inc.Elongated intracorporal medical device
US823155113 Dic 201031 Jul 2012Boston Scientific Scimed, Inc.Elongate medical device with continuous reinforcement member
US823164731 Dic 200831 Jul 2012Boston Scientific Scimed, Inc.Catheter having an improved torque transmitting shaft
US825197627 Oct 200928 Ago 2012Boston Scientific Scimed, Inc.Medical device incorporating a polymer blend
US825727931 Jul 20074 Sep 2012Boston Scientific Scimed, Inc.Medical device for navigation through anatomy and method of making same
US82678727 Jul 200518 Sep 2012St. Jude Medical, Cardiology Division, Inc.Steerable guide wire with torsionally stable tip
US829282712 Dic 200523 Oct 2012Boston Scientific Scimed, Inc.Micromachined medical devices
US829291719 Dic 200723 Oct 2012Boston Scientific Scimed, Inc.Medical closure device
US829593917 May 201123 Oct 2012Nanostim, Inc.Programmer for biostimulator system
US830352025 Ago 20086 Nov 2012Boston Scientific Scimed, Inc.Medical device including actuator
US831781630 Sep 200227 Nov 2012Acclarent, Inc.Balloon catheters and methods for treating paranasal sinuses
US833751910 Jul 200325 Dic 2012Boston Scientific Scimed, Inc.Embolic protection filtering device
US834886028 Sep 20118 Ene 2013Terumo Kabushiki KaishaGuide wire
US835202513 Oct 20068 Ene 2013Nanostim, Inc.Leadless cardiac pacemaker triggered by conductive communication
US8353850 *15 Jun 200915 Ene 2013St. Jude Medical, Cardiology Division, Inc.Steerable guide wire with torsionally stable tip
US836109619 Sep 201129 Ene 2013Boston Scientific Scimed, Inc.Cutting balloon catheter having flexible atherotomes
US837205611 Feb 201112 Feb 2013Boston Scientific Scimed, Inc.Hybrid micro guide catheter
US83769617 Abr 200819 Feb 2013Boston Scientific Scimed, Inc.Micromachined composite guidewire structure with anisotropic bending properties
US837703517 Ene 200319 Feb 2013Boston Scientific Scimed, Inc.Unbalanced reinforcement members for medical device
US837801127 Dic 200719 Feb 2013Boston Scientific Scimed, Inc.Enhanced durability of hydrophilic coatings
US838864229 Ago 20085 Mar 2013Acclarent, Inc.Implantable devices and methods for treating sinusitis and other disorders
US84091142 Ago 20072 Abr 2013Boston Scientific Scimed, Inc.Composite elongate medical device including distal tubular member
US841447316 Sep 20099 Abr 2013Acclarent, Inc.Methods and apparatus for treating disorders of the ear nose and throat
US841450615 Jun 20079 Abr 2013Boston Scientific Scimed, Inc.Composite guidewire
US84196586 Sep 200616 Abr 2013Boston Scientific Scimed, Inc.Medical device including structure for crossing an occlusion in a vessel
US842545729 Dic 200923 Abr 2013Acclarent, Inc.Devices, systems and methods for diagnosing and treating sinusitus and other disorder of the ears, nose and/or throat
US843529024 Mar 20107 May 2013Acclarent, Inc.System and method for treatment of non-ventilating middle ear by providing a gas pathway through the nasopharynx
US843968729 Dic 200614 May 2013Acclarent, Inc.Apparatus and method for simulated insertion and positioning of guidewares and other interventional devices
US844466128 Jun 200721 May 2013Stryker CorporationUnfolding balloon catheter for proximal embolus protection
US84495266 Dic 200728 May 2013Boston Scientific Scimed, Inc.Torqueable soft tip medical device and method of usage
US84495662 Jun 201128 May 2013Nexgen Medical Systems, Inc.Thrombus removal system and process
US845774213 Oct 20064 Jun 2013Nanostim, Inc.Leadless cardiac pacemaker system for usage in combination with an implantable cardioverter-defibrillator
US84602133 Ene 200811 Jun 2013Boston Scientific Scimed, Inc.Cut tubular members for a medical device and methods for making and using the same
US846031312 Ago 201111 Jun 2013Stryker CorporationLaser-cut clot puller
US84806972 Jun 20119 Jul 2013Nexgen Medical Systems, Inc.Thrombus removal system and process
US84851998 May 200716 Jul 2013Acclarent, Inc.Methods and devices for protecting nasal turbinate during surgery
US848599220 Jul 201016 Jul 2013Boston Scientific Scimed, Inc.Medical device having segmented construction
US8486010 *5 Abr 201216 Jul 2013Olympus Medical Systems Corp.Bendable catheter
US8527068 *2 Feb 20103 Sep 2013Nanostim, Inc.Leadless cardiac pacemaker with secondary fixation capability
US853524310 Sep 200817 Sep 2013Boston Scientific Scimed, Inc.Medical devices and tapered tubular members for use in medical devices
US854066815 Sep 201124 Sep 2013Boston Scientific Scimed, Inc.Catheter including a compliant balloon
US854320512 Oct 201124 Sep 2013Nanostim, Inc.Temperature sensor for a leadless cardiac pacemaker
US855102013 Sep 20078 Oct 2013Boston Scientific Scimed, Inc.Crossing guidewire
US855102131 Mar 20118 Oct 2013Boston Scientific Scimed, Inc.Guidewire with an improved flexural rigidity profile
US855691415 Dic 200615 Oct 2013Boston Scientific Scimed, Inc.Medical device including structure for crossing an occlusion in a vessel
US8585613 *27 Jun 201119 Nov 2013Asahi Intecc Co., Ltd.Guidewire
US85856436 Mar 201219 Nov 2013Stryker CorporationBalloon catheter and method of manufacture
US860312212 Oct 200710 Dic 2013Nexgen Medical Systems, IncorporatedThrombus removal system and process
US861531013 Dic 201124 Dic 2013Pacesetter, Inc.Delivery catheter systems and methods
US86171934 May 201231 Dic 2013Boston Scientific Scimed, Inc.Balloon catheter with improved pushability
US863671622 May 201228 Ene 2014Boston Scientific Scimed, Inc.Medical device
US869090319 Dic 20128 Abr 2014Boston Scientific Scimed, Inc.Cutting balloon catheter having flexible atherotomes
US870262629 Dic 200622 Abr 2014Acclarent, Inc.Guidewires for performing image guided procedures
US871516930 Oct 20076 May 2014Acclarent, Inc.Devices, systems and methods useable for treating sinusitis
US872159123 Ene 201213 May 2014Acclarent, Inc.Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures
US87409296 Feb 20023 Jun 2014Acclarent, Inc.Spacing device for releasing active substances in the paranasal sinus
US874738924 Abr 200710 Jun 2014Acclarent, Inc.Systems for treating disorders of the ear, nose and throat
US876470930 Jun 20101 Jul 2014Acclarent, Inc.Devices, systems and methods for treating disorders of the ear, nose and throat
US876472618 Ago 20091 Jul 2014Acclarent, Inc.Devices, systems and methods useable for treating sinusitis
US876472922 Dic 20081 Jul 2014Acclarent, Inc.Frontal sinus spacer
US87647869 Oct 20121 Jul 2014Acclarent, Inc.Balloon catheters and methods for treating paranasal sinuses
US877792615 Mar 201315 Jul 2014Acclarent, Inc.Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasel or paranasal structures
US87843378 Oct 201322 Jul 2014Boston Scientific Scimed, Inc.Catheter with an improved flexural rigidity profile
US878446823 Sep 201122 Jul 2014Boston Scientific Scimed, Inc.Stent delivery systems and locking members for use with stent delivery systems
US87880357 Dic 201222 Jul 2014Pacesetter, Inc.Leadless cardiac pacemaker triggered by conductive communication
US878805317 Oct 201222 Jul 2014Pacesetter, Inc.Programmer for biostimulator system
US879036410 Dic 200929 Jul 2014Boston Scientific Scimed, Inc.Introducer sheath for use with an embolic coil device and methods for making and using the same
US87952023 Feb 20125 Ago 2014Boston Scientific Scimed, Inc.Guidewires and methods for making and using the same
US879525410 Dic 20095 Ago 2014Boston Scientific Scimed, Inc.Medical devices with a slotted tubular member having improved stress distribution
US879874519 Abr 20135 Ago 2014Pacesetter, Inc.Leadless cardiac pacemaker system for usage in combination with an implantable cardioverter-defibrillator
US880163331 Ago 200912 Ago 2014Neometrics, Inc.High-modulus superelastic alloy wire for medical and dental purposes
US88214776 Ago 20072 Sep 2014Boston Scientific Scimed, Inc.Alternative micromachined structures
US88214782 Mar 20122 Sep 2014Boston Scientific Scimed, Inc.Catheter with variable stiffness
US882804118 Mar 20109 Sep 2014Acclarent, Inc.Devices, systems and methods useable for treating sinusitis
US88521437 Abr 20107 Oct 2014Acclarent, Inc.Devices, systems and methods for treating disorders of the ear, nose and throat
US8852223 *6 Abr 20077 Oct 2014Cordis CorporationFixed wire dilatation catheter with an elongateable distal end
US885578926 Jul 20117 Oct 2014Pacesetter, Inc.Implantable biostimulator delivery system
US885858618 Ene 200714 Oct 2014Acclarent, Inc.Methods for enlarging ostia of paranasal sinuses
US88647879 Abr 200821 Oct 2014Acclarent, Inc.Ethmoidotomy system and implantable spacer devices having therapeutic substance delivery capability for treatment of paranasal sinusitis
US887079031 Jul 200728 Oct 2014Boston Scientific Scimed, Inc.Medical device for navigation through anatomy and method of making same
US887089329 Abr 201028 Oct 2014Acclarent, Inc.Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, nose and/or throat
US889461416 Feb 200625 Nov 2014Acclarent, Inc.Devices, systems and methods useable for treating frontal sinusitis
US890016331 Jul 20072 Dic 2014Precision Vascular Systems, Inc.Medical device for navigation through anatomy and method of making same
US890592226 Mar 20129 Dic 2014Acclarent, Inc.Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, nose and/or throat
US891181422 Dic 201016 Dic 2014Boston Scientific Scimed, Inc.Medical device coating configuration and method for improved lubricity and durability
US891586531 Jul 200723 Dic 2014Precision Vascular Systems, Inc.Medical device for navigation through anatomy and method of making same
US893223531 Jul 200713 Ene 2015Precision Vascular Systems, Inc.Medical device for navigation through anatomy and method of making same
US893227616 May 200713 Ene 2015Acclarent, Inc.Shapeable guide catheters and related methods
US893655831 Jul 200720 Ene 2015Precision Vascular Systems, Inc.Medical device for navigation through anatomy and method of making same
US893991631 Jul 200727 Ene 2015Precision Vascular Systems, Inc.Medical device for navigation through anatomy and method of making same
US894504720 Jul 20093 Feb 2015Boston Scientific Scimed, Inc.Traction balloon
US894508828 Abr 20103 Feb 2015Acclarent, Inc.Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures
US895122518 May 200610 Feb 2015Acclarent, Inc.Catheters with non-removable guide members useable for treatment of sinusitis
US896139831 Oct 200724 Feb 2015Acclarent, Inc.Methods and apparatus for treating disorders of the ear, nose and throat
US896149529 Oct 200724 Feb 2015Acclarent, Inc.Devices, systems and methods for treating disorders of the ear, nose and throat
US896826918 Ene 20123 Mar 2015Acclarent, Inc.Multi-conduit balloon catheter
US897988830 Jul 200917 Mar 2015Acclarent, Inc.Paranasal ostium finder devices and methods
US899609531 Ene 201331 Mar 2015Boston Scientific Scimed, Inc.Guide extension catheter
US900513822 Ago 200614 Abr 2015Cook Medical Technologies LlcWire guide having distal coupling tip
US901724617 Nov 201128 Abr 2015Boston Scientific Scimed, Inc.Biliary catheter systems including stabilizing members
US901735320 Ene 201428 Abr 2015Boston Scientific Scimed, Inc.Cutting balloon catheter having flexible atherotomes
US902061112 Oct 201128 Abr 2015Pacesetter, Inc.Leadless cardiac pacemaker with anti-unscrewing feature
US902301128 Ene 20145 May 2015Boston Scientific Scimed, Inc.Medical device
US90396573 Sep 200926 May 2015Acclarent, Inc.Implantable devices and methods for delivering drugs and other substances to treat sinusitis and other disorders
US903968021 Abr 200826 May 2015Acclarent, Inc.Implantable devices and methods for delivering drugs and other substances to treat sinusitis and other disorders
US905044022 Sep 20069 Jun 2015Acclarent, Inc.Multi-conduit balloon catheter
US905596522 Mar 201016 Jun 2015Acclarent, Inc.Devices, systems and methods useable for treating sinusitis
US90561897 Mar 201416 Jun 2015Terumo Kabushiki KaishaGuide wire
US906069223 May 201323 Jun 2015Pacesetter, Inc.Temperature sensor for a leadless cardiac pacemaker
US90726266 May 20137 Jul 2015Acclarent, Inc.System and method for treatment of non-ventilating middle ear by providing a gas pathway through the nasopharynx
US907287411 May 20127 Jul 2015Boston Scientific Scimed, Inc.Medical devices with a heat transfer region and a heat sink region and methods for manufacturing medical devices
US907291329 Abr 20117 Jul 2015Pacesetter, Inc.Rate responsive leadless cardiac pacemaker
US907900016 Oct 201214 Jul 2015Boston Scientific Scimed, Inc.Integrated crossing balloon catheter
US908469217 Nov 201121 Jul 2015Boston Scientific Scimed, Inc.Stent delivery system
US908487615 Mar 201321 Jul 2015Acclarent, Inc.Implantable devices and methods for delivering drugs and other substances to treat sinusitis and other disorders
US908925815 Mar 200728 Jul 2015Acclarent, Inc.Endoscopic methods and devices for transnasal procedures
US910138416 Ene 200911 Ago 2015Acclarent, Inc.Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, Nose and/or throat
US91075748 Dic 201118 Ago 2015Acclarent, Inc.Endoscopic methods and devices for transnasal procedures
US911962610 Jul 20141 Sep 2015Boston Scientific Scimed, Inc.Method for assembling introducer sheath with an embolic coil device
US9119904 *8 Mar 20131 Sep 2015Abbott LaboratoriesGuide wire utilizing a nickel—titanium alloy having high elastic modulus in the martensitic phase
US912603213 Dic 20118 Sep 2015Pacesetter, Inc.Pacemaker retrieval systems and methods
US915549224 Sep 201013 Oct 2015Acclarent, Inc.Sinus illumination lightwire device
US916204020 Dic 201220 Oct 2015Stryker CorporationBalloon catheter and method of use
US916204628 Sep 201220 Oct 2015Boston Scientific Scimed, Inc.Deflectable medical devices
US916796131 Oct 200727 Oct 2015Acclarent, Inc.Methods and apparatus for treating disorders of the ear nose and throat
US916838319 Oct 201127 Oct 2015Pacesetter, Inc.Leadless cardiac pacemaker with conducted communication
US91798235 Jun 200910 Nov 2015Acclarent, Inc.Methods and devices for facilitating visualization in a surgical environment
US919277427 Jun 201424 Nov 2015Pacesetter, Inc.Cardiac pacemaker system for usage in combination with an implantable cardioverter-defibrillator
US919873619 Abr 20121 Dic 2015Acclarent, Inc.Adapter for attaching electromagnetic image guidance components to a medical device
US921629813 Oct 200622 Dic 2015Pacesetter, Inc.Leadless cardiac pacemaker system with conductive communication
US922061922 Sep 201129 Dic 2015Boston Scientific Scimed, Inc.Stent delivery system
US922087930 Abr 201429 Dic 2015Acclarent, Inc.Devices, systems and methods useable for treating sinusitis
US922703711 Jun 20135 Ene 2016Boston Scientific Scimed, Inc.Cut tubular members for a medical device and methods for making and using the same
US922707723 Nov 20105 Ene 2016Pacesetter, Inc.Leadless cardiac pacemaker triggered by conductive communication
US924183421 Mar 201426 Ene 2016Acclarent, Inc.Devices, systems and methods for treating disorders of the ear, nose and throat
US924210220 Dic 201126 Ene 2016Pacesetter, Inc.Leadless pacemaker with radial fixation mechanism
US926540731 Jul 200723 Feb 2016Acclarent, Inc.Endoscopic methods and devices for transnasal procedures
US926563718 Nov 201123 Feb 2016Boston Scientific Scimed, Inc.Rapid exchange stent delivery system
US926592018 May 201223 Feb 2016Boston Scientific Scimed, Inc.Balloon catheter with improved pushability
US927215514 Ago 20131 Mar 2016Pacesetter, Inc.Leadless cardiac pacemaker with secondary fixation capability
US927819827 Dic 20128 Mar 2016Boston Scientific Scimed, Inc.Biliary access catheter system and methods for accessing the biliary tree
US92866733 Oct 201315 Mar 2016Volcano CorporationSystems for correcting distortions in a medical image and methods of use thereof
US929291813 Mar 201422 Mar 2016Volcano CorporationMethods and systems for transforming luminal images
US92958147 Mar 201429 Mar 2016Terumo Kabushiki KaishaGuide wire
US930168712 Mar 20145 Abr 2016Volcano CorporationSystem and method for OCT depth calibration
US93079262 Oct 201312 Abr 2016Volcano CorporationAutomatic stent detection
US93083614 Mar 201312 Abr 2016Acclarent, Inc.Implantable devices and methods for treating sinusitis and other disorders
US931435913 Mar 201419 Abr 2016Boston Scientific Scimed, Inc.Stent delivery system
US93241412 Oct 201326 Abr 2016Volcano CorporationRemoval of A-scan streaking artifact
US93394018 Mar 201317 May 2016Abbott LaboratoriesMedical device utilizing a nickel-titanium ternary alloy having high elastic modulus
US935175016 Dic 200931 May 2016Acclarent, Inc.Devices and methods for treating maxillary sinus disease
US935840013 Oct 20067 Jun 2016Pacesetter, Inc.Leadless cardiac pacemaker
US936063031 Ago 20127 Jun 2016Volcano CorporationOptical-electrical rotary joint and methods of use
US936796525 Sep 201314 Jun 2016Volcano CorporationSystems and methods for generating images of tissue
US93706495 Feb 201521 Jun 2016Acclarent, Inc.Devices, systems and methods useable for treating sinusitis
US937523415 Oct 201328 Jun 2016Boston Scientific Scimed, Inc.Medical device including structure for crossing an occlusion in a vessel
US938326317 Dic 20135 Jul 2016Volcano CorporationSystems and methods for narrowing a wavelength emission of light
US93991211 Jul 200926 Jul 2016Acclarent, Inc.Systems and methods for transnasal dilation of passageways in the ear, nose or throat
US940903316 Oct 20159 Ago 2016Pacesetter, Inc.Leadless cardiac pacemaker system for usage in combination with an implantable cardioverter-defibrillator
US942971314 Abr 201530 Ago 2016Boston Scientific Scimed, Inc.Self-cleaning optical connector
US943343715 Mar 20136 Sep 2016Acclarent, Inc.Apparatus and method for treatment of ethmoid sinusitis
US943376223 Sep 20136 Sep 2016Boston Scientific Scimed, Inc.Catheter including a compliant balloon
US944578422 Sep 200520 Sep 2016Boston Scientific Scimed, IncIntravascular ultrasound catheter
US944622031 Ago 201520 Sep 2016Abbott LaboratoriesGuide wire utilizing a cold worked nickel—titanium—niobium ternary alloy
US945686713 Mar 20144 Oct 2016Boston Scientific Scimed Inc.Open irrigated ablation catheter
US94571754 Sep 20154 Oct 2016Acclarent, Inc.Balloon catheters and methods for treating paranasal sinuses
US946306818 Jun 201311 Oct 2016Acclarent, Inc.Methods and devices for protecting nasal turbinates
US946836219 Abr 201218 Oct 2016Acclarent, Inc.Endoscopic methods and devices for transnasal procedures
US94789404 Oct 201325 Oct 2016Volcano CorporationSystems and methods for amplifying light
US94808189 Ago 20121 Nov 2016Boston Scientific Scimed, Inc.Rotatable tip for endoscopic medical devices
US948614320 Dic 20138 Nov 2016Volcano CorporationIntravascular forward imaging device
US948661116 Ago 20138 Nov 2016Boston Scientific Scimed, Inc.Guide extension catheter
US95112365 Nov 20126 Dic 2016Pacesetter, Inc.Leadless cardiac pacemaker with integral battery and redundant welds
US955469114 May 200731 Ene 2017Acclarent, Inc.Endoscopic methods and devices for transnasal procedures
US956302328 Jul 20167 Feb 2017Boston Scientific Scimed, Inc.Self-cleaning optical connector
US957248019 Jun 201421 Feb 2017Acclarent, Inc.Methods and devices for facilitating visualization in a surgical environment
US958574918 Sep 20147 Mar 2017Boston Scientific Scimed, Inc.Replacement heart valve assembly
US959236315 Abr 201514 Mar 2017Boston Scientific Scimed, Inc.Medical device
US959699322 Feb 201221 Mar 2017Volcano CorporationAutomatic calibration systems and methods of use
US96035065 Jun 200928 Mar 2017Acclarent, Inc.Methods and devices for facilitating visualization in a surgical environment
US960361927 Mar 201528 Mar 2017Boston Scientific Scimed, Inc.Cutting balloon catheter having flexible atherotomes
US961042816 Oct 20144 Abr 2017Acclarent, Inc.Devices, systems and methods useable for treating frontal sinusitis
US961210516 Dic 20134 Abr 2017Volcano CorporationPolarization sensitive optical coherence tomography system
US961577518 Ene 201211 Abr 2017Acclarent, Inc.Methods and devices for ostium measurements
US961587913 Mar 201411 Abr 2017Boston Scientific Scimed, Inc.Open irrigated ablation catheter with proximal cooling
US962270614 Jul 200818 Abr 2017Volcano CorporationCatheter for in vivo imaging
US96296564 Sep 201525 Abr 2017Acclarent, Inc.Adapter for attaching electromagnetic image guidance components to a medical device
US96296845 Mar 201425 Abr 2017Acclarent, Inc.Apparatus and method for treatment of ethmoid sinusitis
US963625827 May 20152 May 2017Acclarent, Inc.System and method for treatment of non-ventilating middle ear by providing a gas pathway through the nasopharynx
US964947730 Abr 201416 May 2017Acclarent, Inc.Frontal sinus spacer
US968765519 May 201527 Jun 2017Pacesetter, Inc.Temperature sensor for a leadless cardiac pacemaker
US968766612 Jul 201627 Jun 2017Pacesetter, Inc.Leadless cardiac pacemaker system for usage in combination with an implantable cardioverter-defibrillator
US970937916 Dic 201318 Jul 2017Volcano CorporationOptical coherence tomography system that is reconfigurable between different imaging modes
US973061320 Dic 201315 Ago 2017Volcano CorporationLocating intravascular images
US97440352 Oct 201529 Ago 2017Boston Scientific Scimed, Inc.Everting heart valve
US975040130 Jul 20145 Sep 2017Acclarent, Inc.Paranasal ostium finder devices and methods
US976411824 Mar 201519 Sep 2017Boston Scientific Scimed, Inc.Guide extension catheter
US97701727 Mar 201426 Sep 2017Volcano CorporationMultimodal segmentation in intravascular images
US977552310 Oct 20143 Oct 2017Boston Scientific Scimed, Inc.Pressure sensing guidewire and methods for calculating fractional flow reserve
US978212930 Jul 201510 Oct 2017Boston Scientific Scimed, Inc.Pressure sensing guidewires
US978894227 Ene 201617 Oct 2017Boston Scientific Scimed Inc.Prosthetic heart valve having tubular seal
US97953074 Dic 201524 Oct 2017Boston Scientific Scimed, Inc.Pressure sensing guidewires
US98020541 Ago 201331 Oct 2017Pacesetter, Inc.Biostimulator circuit with flying cell
US98085957 Ago 20077 Nov 2017Boston Scientific Scimed, IncMicrofabricated catheter with improved bonding structure
US20030009095 *21 May 20029 Ene 2003Skarda James R.Malleable elongated medical device
US20030114777 *18 Dic 200119 Jun 2003Scimed Life Systems, Inc.Super elastic guidewire with shape retention tip
US20030139689 *23 Dic 200224 Jul 2003Leonid ShturmanHigh torque, low profile intravascular guidewire system
US20030153971 *14 Feb 200214 Ago 2003Chandru ChandrasekaranMetal reinforced biodegradable intraluminal stents
US20030153972 *14 Feb 200214 Ago 2003Michael HelmusBiodegradable implantable or insertable medical devices with controlled change of physical properties leading to biomechanical compatibility
US20040030266 *7 Ago 200312 Feb 2004Terumo Kabushiki Kaisha .Guide wire
US20040039304 *23 Ago 200226 Feb 2004Connors John J.Wire guide
US20040039309 *7 Ago 200326 Feb 2004Terumo Kabushiki Kaisha.Guide wire
US20040064069 *30 Sep 20021 Abr 2004Reynolds Brian R.Medical device with support member
US20040106878 *3 Dic 20023 Jun 2004Scimed Life Systems, Inc.Composite medical device with markers
US20040122340 *23 Dic 200224 Jun 2004Anthony VrbaGuidewire tip construction
US20040142643 *17 Ene 200322 Jul 2004Scimed Life Systems, Inc.Straightening and centerless grinding of wire for use with medical devices
US20040152941 *3 Feb 20035 Ago 2004Scimed Life Systems, Inc.Medical device with changeable tip flexibility
US20040167438 *26 Feb 200326 Ago 2004Sharrow James S.Reinforced medical device
US20040167439 *26 Feb 200326 Ago 2004Sharrow James S.Guidewire having textured proximal portion
US20040167440 *26 Feb 200326 Ago 2004Sharrow James S.Multiple diameter guidewire
US20040167441 *26 Feb 200326 Ago 2004Reynolds Brian R.Composite medical device
US20040167443 *10 Dic 200326 Ago 2004Scimed Life Systems, Inc.Elongated intracorporal medical device
US20040175525 *29 Dic 20039 Sep 2004Scimed Life Systems, Inc.Catheter incorporating an improved polymer shaft
US20040185179 *30 Mar 200423 Sep 2004Cook IncorporatedWire guide
US20040193140 *27 Mar 200330 Sep 2004Scimed Life Systems,Inc.Medical device
US20040234703 *4 Jun 200325 Nov 2004Frautschi Jack R.Method of forming a polymer layer on a metal surface
US20040254450 *27 May 200316 Dic 2004Scimed Life Systems, Inc.Medical device having segmented construction
US20050008869 *20 Feb 200413 Ene 2005Tamisha ClarkMedical device with adherent coating, and method for preparing same
US20050038447 *12 Ago 200317 Feb 2005Scimed Life Systems, Inc.Laser-cut clot puller
US20050061771 *22 Sep 200324 Mar 2005Scimed Life Systems, Inc.Surface modified reinforcing member for medical device and method for making same
US20050065456 *22 Sep 200324 Mar 2005Scimed Life Systems, Inc.Guidewire with reinforcing member
US20050085826 *21 Oct 200321 Abr 2005Scimed Life Systems, Inc.Unfolding balloon catheter for proximal embolus protection
US20050085846 *21 Oct 200321 Abr 2005Scimed Life Systems, Inc.Clot removal device
US20050096567 *30 Oct 20035 May 2005Scimed Life Systems, Inc.Guidewire having an embedded matrix polymer
US20050096665 *30 Oct 20035 May 2005Scimed Life Systems, Inc.Guidewire having a helically contoured portion
US20050124917 *5 Dic 20039 Jun 2005Scimed Life Systems, Inc.Elongated medical device for intracorporal use
US20050131316 *15 Dic 200316 Jun 2005Cook IncorporatedGuidewire with flexible tip
US20050148866 *29 Dic 20037 Jul 2005Scimed Life Systems, Inc.Medical device with modified marker band
US20050148901 *30 Dic 20037 Jul 2005Scimed Life Systems, Inc.Distal assembly for a medical device
US20050209533 *16 Mar 200522 Sep 2005Lorenz Mark ASecond wire apparatus and installation procedure
US20050226915 *20 Jun 200513 Oct 2005Oramelts Corporation, A Washington CorporationMethod for manufacturing and packaging oral patches with rounded edges
US20050234427 *19 Abr 200420 Oct 2005Scimed Life Systems, Inc.Hybrid micro guide catheter
US20050283095 *22 Jun 200422 Dic 2005Scimed Life Systems, Inc.Medical device including actuator
US20060064036 *21 Sep 200423 Mar 2006Cook IncorporatedVariable flexibility wire guide
US20060122537 *30 Dic 20058 Jun 2006Brian ReynoldsComposite guidewire
US20070010762 *7 Jul 200511 Ene 2007Ressemann Thomas VSteerable guide wire with torsionally stable tip
US20070010763 *27 Jun 200611 Ene 2007Cook IncorporatedWire guide advancement system
US20070088328 *22 Ago 200619 Abr 2007Cook IncorporatedWire guide having distal coupling tip
US20070088394 *13 Oct 200619 Abr 2007Jacobson Peter MLeadless cardiac pacemaker system for usage in combination with an implantable cardioverter-defibrillator
US20070088398 *13 Oct 200619 Abr 2007Jacobson Peter MLeadless cardiac pacemaker triggered by conductive communication
US20070100257 *13 Oct 20063 May 2007Cook IncorporatedCoupling wire guide
US20070112282 *13 Dic 200617 May 2007Boston Scientific Scimed, Inc.Composite medical device with markers
US20070118052 *13 Oct 200624 May 2007Cook IncorporatedWire guide having distal coupling tip
US20070118053 *13 Oct 200624 May 2007Cook IncorporatedIdentifiable wire guide
US20070123805 *31 Ene 200731 May 2007Boston Scientific Scimed, Inc.Elongated intracorporal medical device
US20070129619 *3 Oct 20067 Jun 2007Isense CorporationCompound material analyte sensor
US20070135734 *31 Ene 200714 Jun 2007Boston Scientific Scimed, Inc.Composite guidewire
US20070135763 *12 Dic 200514 Jun 2007Musbach Frank AMicromachined medical devices
US20070160743 *9 Ene 200612 Jul 2007Babitt John LMethod for coating biocompatible material on a substrate
US20070185414 *22 Ago 20069 Ago 2007Cook IncorporatedWire guide having distal coupling tip
US20070191790 *15 Feb 200716 Ago 2007Cook IncorporatedWire guide having distal coupling tip
US20070199607 *30 Abr 200730 Ago 2007Terumo Kabushiki KaishaGuide wire
US20070244414 *15 Jun 200718 Oct 2007Boston Scientific Scimed, Inc.Composite guidewire
US20070249998 *28 Jun 200725 Oct 2007Boston Scientific Scimed, Inc.Unfolding balloon catheter for proximal embolus protection
US20070255183 *1 May 20061 Nov 2007Boston Scientific Scimed, Inc.Crossing guide wire with corrugated shaping ribbon
US20070265552 *20 Jul 200715 Nov 2007Hiraku MurayamaGuide wire
US20070265553 *20 Jul 200715 Nov 2007Hiraku MurayamaGuide wire
US20070299366 *8 Jun 200627 Dic 2007Sharrow James SGuidewire with polymer jacket and method of making
US20070299367 *14 Jun 200727 Dic 2007Cook IncorporatedWeldable wire guide with distal coupling tip
US20080015471 *27 Jun 200717 Ene 2008Boston Scientific Scimed, Inc.Elongated medical device for intracorporal use
US20080034610 *12 Oct 200714 Feb 2008Flynn Robin LNeck ring cooling
US20080045908 *16 Ago 200621 Feb 2008Boston Scientific Scimed, Inc.Medical device including a metallic tube fillet welded to a core member
US20080097247 *6 Sep 200624 Abr 2008Boston Scientific Scimed, Inc.Medical device including structure for crossing an occlusion in a vessel
US20080097393 *24 Ago 200624 Abr 2008Boston Scientific Scimed, Inc.Medical device coating configuration and method for improved lubricity and durability
US20080097522 *19 Dic 200724 Abr 2008Boston Scientific Scimed, Inc.Medical closure device
US20080114393 *24 Ene 200815 May 2008Boston Scientific Scimed, Inc.Clot removal device
US20080119888 *28 Nov 200722 May 2008Boston Scientific Scimed, Inc.Laser-cut clot puller
US20080125753 *24 Ago 200629 May 2008Boston Scientific Scimed, Inc.Elongate medical device and method of coating the same
US20080249465 *6 Abr 20079 Oct 2008John Kenneth RyderFixed wire dilatation catheter with an elongateable distal end
US20080319403 *25 Ago 200825 Dic 2008Boston Scientific Scimed, Inc.Medical device including actuator
US20090118675 *2 Nov 20077 May 2009Boston Scientific Scimed, Inc.Elongate medical device with a shapeable tip
US20090118704 *2 Nov 20077 May 2009Boston Scientific Scimed, Inc.Interconnected ribbon coils, medical devices including an interconnected ribbon coil, and methods for manufacturing an interconnected ribbon coil
US20090118705 *2 Nov 20077 May 2009Boston Scientific Scimed,Inc.Guidewires with improved fatigue life and methods of making the same
US20090118759 *31 Dic 20087 May 2009Boston Scientific Scimed, Inc.Catheter Having an Improved Torque Transmitting Shaft
US20090124984 *23 Mar 200614 May 2009Takao HanawaMedical Appliance and Process for Producing the Appliance
US20090157047 *13 Dic 200718 Jun 2009Boston Scientific Scimed, Inc.Medical device coatings and methods of forming such coatings
US20090171302 *27 Dic 20072 Jul 2009Boston Scientific Scimed, Inc.Enhanced durability of hydrophilic coatings
US20090177185 *3 Ene 20089 Jul 2009Boston Scientific Scimed, Inc.Cut tubular members for a medical device and methods for making and using the same
US20090227900 *10 Mar 200810 Sep 2009Isaac KimCorewire design and construction for medical devices
US20090264907 *18 Abr 200822 Oct 2009Boston Scientific Scimed, Inc.Medical device for crossing an occluded blood vessel
US20090299332 *30 May 20083 Dic 2009Boston Scientific Scimed, Inc.Medical device including a polymer sleeve and a coil wound into the polymer sleeve
US20090318835 *15 Jun 200924 Dic 2009Ressemann Thomas VSteerable guide wire with torsionally stable tip
US20100048758 *22 Ago 200825 Feb 2010Boston Scientific Scimed, Inc.Lubricious coating composition for devices
US20100119833 *25 Jul 200713 May 2010Niels Jorgen MadsenPhoto-curing of thermoplastic coatings
US20100159117 *1 Mar 201024 Jun 2010Boston Scientific Scimed, Inc.Super Elastic Guidewire With Shape Retention Tip
US20100160953 *10 Dic 200924 Jun 2010Boston Scientific Scimed, Inc.Introducer sheath for use with an embolic coil device and methods for making and using the same
US20100198288 *2 Feb 20105 Ago 2010Alan OstroffLeadless Cardiac Pacemaker with Secondary Fixation Capability
US20100200542 *26 Mar 201012 Ago 2010Tamisha ClarkMedical device with adherent coating, and method for preparing same
US20100286566 *20 Jul 201011 Nov 2010Boston Scientific Scimed, Inc.Medical device having segmented construction
US20100318068 *18 Ago 201016 Dic 2010Cook IncorporatedWire guide having distal coupling tip for attachment to a previously introduced wire guide
US20110054351 *31 Ago 20093 Mar 2011Neometrics, Inc.High-modulus superelastic alloy wire for medical and dental purposes
US20110091639 *22 Dic 201021 Abr 2011Boston Scientific Scimed, Inc.Medical Device Coating Configuration and Method for Improved Lubricity and Durability
US20110098648 *26 Oct 201028 Abr 2011Tomihisa KatoMedical guide wire, a method of making the same, an assembly of microcatheter and guiding catheter combined with the medical guide wire
US20110118817 *17 Nov 200919 May 2011Boston Scientific Scimed, Inc.Stent delivery system
US20110137163 *11 Feb 20119 Jun 2011Boston Scientific Scimed, Inc.Hybrid Micro Guide Catheter
US20110230908 *2 Jun 201122 Sep 2011Nexgen Medical Systems, Inc.Thrombus removal system and process
US20110230909 *2 Jun 201122 Sep 2011Nexgen Medical Systems, Inc.Thrombus removal system and process
US20120041420 *27 Jun 201116 Feb 2012Asahi Intecc Co., Ltd.Guidewire
US20120265132 *5 Abr 201218 Oct 2012Olympus Medical Systems Corp.Bendable catheter
US20130137928 *27 Nov 201230 May 2013Fujifilm CorporationEndoscope
US20140257247 *8 Mar 201311 Sep 2014Abbott LaboratoriesGuide wire utilizing a nickel-titanium alloy having high elastic modulus in the martensitic phase
US20160250447 *26 Feb 20161 Sep 2016Thomas A. SosAtraumatic micropuncture guidewire and guidewire extension
CN103706020A *31 Dic 20139 Abr 2014广州市凌捷医疗器械有限公司Method for generating super-lubricity coating and guide wire
EP3078352A118 Nov 201112 Oct 2016Boston Scientific Scimed, Inc.Rapid exchange strent delivery system
EP3238669A123 Sep 20111 Nov 2017Boston Scientific Scimed, Inc.Stent delivery systems
WO2003030982A24 Oct 200217 Abr 2003Boston Scientific LimitedComposite guidewire
WO2003068288A1 *13 Feb 200321 Ago 2003Scimed Life Systems, Inc.Biodegradable stents with controlled change of physical properties leading to biomechanical compatibility
WO2004018030A1 *18 Ago 20034 Mar 2004Cook, Inc.Guidewire having different coatings
WO2004043530A131 Jul 200327 May 2004Boston Sceintific LimitedMedical device having flexible distal tip
WO2004075726A224 Feb 200410 Sep 2004Boston Scientific LimitedReinforced medical device
WO2004075941A124 Feb 200410 Sep 2004Boston Scientific LimitedComposite medical device
WO2004093957A125 Nov 20034 Nov 2004Boston Scientific LimitedMedical device
WO2005041787A121 Oct 200412 May 2005Boston Scientific LimitedClot removal device
WO2005041788A121 Oct 200412 May 2005Boston Scientific LimitedUnfolding balloon catheter for proximal embolus protection
WO2005063329A122 Dic 200414 Jul 2005Boston Scientific Limited, An Irish CompagnyMedical device with push force limiter
WO2005065760A16 Dic 200421 Jul 2005Boston Scientific LimitedCatheter incorporating an improved polymer shaft
WO2005065763A130 Dic 200421 Jul 2005Boston Scientific LimitedDistal assembly for a medical device
WO2006065362A1 *27 Oct 200522 Jun 2006Boston Scientific LimitedCatheter tip to reduce wire lock
WO2007082176A2 *8 Ene 200719 Jul 2007Quatro Investments, Lp.Method for coating biocompatible material on a substrate
WO2007082176A3 *8 Ene 200722 Nov 2007Quatro Investments LpMethod for coating biocompatible material on a substrate
WO2008012325A2 *25 Jul 200731 Ene 2008Coloplast A/SPhoto-curing of thermoplastic coatings
WO2008012325A3 *25 Jul 200712 Jun 2008Coloplast AsPhoto-curing of thermoplastic coatings
WO2008085712A121 Dic 200717 Jul 2008Boston Scientific LimitedMethod and apparatus for biliary access and stone retrieval
WO2010068814A110 Dic 200917 Jun 2010Boston Scientific Scimed, Inc.Introducer sheath with an embolic coil device and methods for making the same
WO2010093437A111 Feb 201019 Ago 2010Boston Scientific Scimed, Inc.Medical device having a rotatable shaft
WO2011119872A124 Mar 201129 Sep 2011Nexgen Medical Systems, Inc.Thrombus removal system and process
WO2011123689A131 Mar 20116 Oct 2011Boston Scientific Scimed, Inc.Guidewire with a flexural rigidity profile
WO2012054178A123 Sep 201126 Abr 2012Boston Scientific Scimed, Inc.Stent delivery system with a rolling membrane
WO2012067714A122 Sep 201124 May 2012Boston Scientific Scimed, Inc.Stent delivery system
WO2012067717A123 Sep 201124 May 2012Boston Scientific Scimed, Inc.Stent delivery systems and locking members for use with stent delivery systems
WO2012068389A117 Nov 201124 May 2012Boston Scientific Scimed, Inc.Stent delivery system
WO2012068508A118 Nov 201124 May 2012Boston Scientific Scimed, Inc.Rapid exchange stent delivery system
WO2012106628A13 Feb 20129 Ago 2012Boston Scientific Scimed, Inc.Guidewires and methods for making and using the same
WO2012109468A19 Feb 201216 Ago 2012Boston Scientific Scimed, Inc.Balloon catheter
WO2012122183A16 Mar 201213 Sep 2012Stryker CorporationBalloon catheter and support shaft for same
WO2012125851A115 Mar 201220 Sep 2012Boston Scientific Scimed, Inc.Multiple guidewire system
WO2012162037A115 May 201229 Nov 2012Boston Scientific Scimed, Inc.Balloon catheter
WO2012162183A118 May 201229 Nov 2012Boston Scientific Scimed, Inc.Balloon catheter with improved pushability
WO2012162186A118 May 201229 Nov 2012Boston Scientific Scimed, Inc.Balloon catheter with improved pushability
WO2013003450A127 Jun 20123 Ene 2013Boston Scientific Scimed, Inc.Stent delivery systems and methods for making and using stent delivery systems
WO2013019550A226 Jul 20127 Feb 2013Boston Scientific Scimed, Inc.Rapid exchange stent delivery system
WO2013055826A110 Oct 201218 Abr 2013Boston Scientific Scimed, Inc.Medical devices including ablation electrodes
WO2013058962A128 Sep 201225 Abr 2013Boston Scientific Scimed, Inc.Deflectable medical devices
WO2013067007A131 Oct 201210 May 2013Boston Scientific Scimed, Inc.Rotatable medical device
WO2013067168A11 Nov 201210 May 2013Boston Scientific Scimed, Inc.Stent delivery systems and methods for use
WO2013067180A11 Nov 201210 May 2013Boston Scientific Scimed, Inc.Catheter including a bare metal hypotube
WO2013070569A16 Nov 201216 May 2013Boston Scientific Scimed, Inc.Direct connect flush system
WO2013070758A27 Nov 201216 May 2013Boston Scientific Scimed, Inc.Guide extension catheter
WO2013074662A114 Nov 201223 May 2013Boston Scientific Scimed, Inc.Medical device with one or more sheathing transition members
WO2013074671A114 Nov 201223 May 2013Boston Scientific Scimed, Inc.Medical device with keyed locking structures
WO2013082583A13 Dic 20126 Jun 2013Boston Scientific Scimed, Inc.Medical device handle
WO2013096545A120 Dic 201227 Jun 2013Boston Scientific Scimed, Inc.Medical device delivery systems
WO2013096556A120 Dic 201227 Jun 2013Boston Scientific Scimed, Inc.Medical device handle
WO2013109318A128 Sep 201225 Jul 2013Boston Scientific Scimed, Inc.Renal nerve modulation devices and methods for making and using the same
WO2013116521A231 Ene 20138 Ago 2013Boston Scientific Scimed, Inc.Guide extension catheter
WO2014005095A128 Jun 20133 Ene 2014Boston Scientific Scimed, Inc.Pressure sensing guidewire
WO2014011677A19 Jul 201316 Ene 2014Boston Scientific Scimed, Inc.Expandable guide extension catheter
WO2014012049A112 Jul 201316 Ene 2014Boston Scientific Scimed, Inc.Guide extension catheter
WO2014015062A117 Jul 201323 Ene 2014Boston Scientific Scimed, Inc.Guide extension catheter
WO2014043704A117 Sep 201320 Mar 2014Boston Scientific Scimed, Inc.Pressure sensing guidewire
WO2014149688A14 Mar 201425 Sep 2014Boston Scientific Scimed, Inc.Pressure sensing guidewire
WO2014151615A213 Mar 201425 Sep 2014Boston Scientific Scimed, Inc.Stent delivery system
WO2014151822A213 Mar 201425 Sep 2014Boston Scientific Scimed, Inc.Open irrigated ablation catheter
WO2014151876A113 Mar 201425 Sep 2014Boston Scientific Scimed, Inc.Open irrigated ablation catheter with proximal cooling
WO2014190195A122 May 201427 Nov 2014Boston Scientific Scimed, Inc.Pressure sensing guidewire systems including an optical connector cable
WO2015057518A110 Oct 201423 Abr 2015Boston Scientific Scimed, Inc.Pressure sensing guidewire and methods for calculating fractional flow reserve
WO2015184348A129 May 20153 Dic 2015Boston Scientific Scimed, Inc.Gastrostomy device with controlled shape silicone balloon
WO2015187385A121 May 201510 Dic 2015Boston Scientific Scimed, Inc.Pressure sensing guidewire systems with reduced pressure offsets
WO2016007901A110 Jul 201514 Ene 2016Boston Scientific Scimed, Inc.Ablation medical devices
WO2016011127A215 Jul 201521 Ene 2016Stryker CorporationCoated tubular support members and methods of manufacturing same
WO2016019207A130 Jul 20154 Feb 2016Boston Scientific Scimed, Inc.Pressure sensing guidewires
WO2016040382A18 Sep 201517 Mar 2016Boston Scientific Scimed, Inc.Valve locking mechanism
WO2016073597A14 Nov 201512 May 2016Boston Scientific Scimed, Inc.Tracheal stent
WO2016081883A120 Nov 201526 May 2016Boston Scientific Scimed, Inc.Valve locking mechanism
WO2016090272A14 Dic 20159 Jun 2016Boston Scientific Scimed, Inc.Pressure sensing guidewires
WO2016196161A126 May 20168 Dic 2016Boston Scientific Scimed, Inc.Guide extension catheter
WO2017004194A129 Jun 20165 Ene 2017Boston Scientific Scimed, Inc.Medical device having outer polymeric member including one or more cuts
WO2017007678A130 Jun 201612 Ene 2017Boston Scientific Scimed, Inc.Methods and devices for maintaining an open pathway in a vessel
WO2017039979A19 Ago 20169 Mar 2017Boston Scientific Scimed, Inc.Pressure sensing guidewires
WO2017053795A223 Sep 201630 Mar 2017Boston Scientific Scimed, Inc.Methods and devices for tissue biopsy
WO2017070171A119 Oct 201627 Abr 2017Boston Scientific Scimed, Inc.Delivery device for use with an embolic coil device and methods for making and using the same
WO2017176553A130 Mar 201712 Oct 2017Boston Scientific Scimed, Inc.Stent delivery device
WO2017189577A125 Abr 20172 Nov 2017Boston Scientific LimitedPercutaneous access device with adjustable depth stop
Clasificaciones
Clasificación de EE.UU.600/585, 604/526, 604/523, 604/96.01
Clasificación internacionalA61L31/10, A61L31/02
Clasificación cooperativaA61M25/09, A61M2025/09133, A61L2400/16, A61M2025/09175, A61L31/022, A61M2025/09141, A61L31/10, A61M25/09033
Clasificación europeaA61L31/02B, A61M25/09, A61L31/10
Eventos legales
FechaCódigoEventoDescripción
22 Feb 1999ASAssignment
Owner name: TARGET THERAPEUTICS, INC., CALIFORNIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:PALERMO, THOMAS J.;REEL/FRAME:009776/0862
Effective date: 19990116
29 Mar 2004FPAYFee payment
Year of fee payment: 4
20 Mar 2008FPAYFee payment
Year of fee payment: 8
11 Abr 2012FPAYFee payment
Year of fee payment: 12