US6350468B1 - Double capsule for the administration of active principles in multiple therapies - Google Patents
Double capsule for the administration of active principles in multiple therapies Download PDFInfo
- Publication number
- US6350468B1 US6350468B1 US09/581,721 US58172100A US6350468B1 US 6350468 B1 US6350468 B1 US 6350468B1 US 58172100 A US58172100 A US 58172100A US 6350468 B1 US6350468 B1 US 6350468B1
- Authority
- US
- United States
- Prior art keywords
- bismuth
- group
- antibiotic
- dosage form
- pharmaceutical dosage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Abstract
Description
TABLE 1 |
SIZE OF THE JELLY CAPSULES |
Total length | Diameter of | Thickness | ||
Type of | Format of | of the capsule | the external | of the wall |
capsule | Capsule | (nm +/− 0.3 nm) | body (nm) | (nm) |
CONI-SNAP | 000 | 26.14 | 9.55 | |
SNAP-FIT | 00 | 23.3 | 8.18 | 0.231 |
0+ | 23.8 | 7.36 | 0.224 | |
0 | 21.2 | 7.33 | 0.212 | |
1 | 19.0 | 6.63 | 0.216 | |
2 | 17.5 | 6.07 | 0.211 | |
3 | 15.6 | 5.57 | 0.203 | |
4 | 13.9 | 5.05 | 0.198 | |
5 | 11.0 | 4.64 | 0.173 | |
CONI-SNAP | A | 18.00 | 8.18 | 0.231 |
SUPRO | B | 14.20 | 8.18 | 0.231 |
C | 13.50 | 7.33 | 0.224 | |
D | 12.60 | 6.63 | 0.216 | |
E | 11.60 | 6.07 | 0.211 | |
LICAPS | 0 | 21.70 | 7.33 | 0.224 |
1 | 19.70 | 6.63 | 0.216 | |
2 | 17.90 | 6.70 | 0.211 | |
TABLE 2 |
AFTER 1 MONTH |
ROOM | ||||
TEMPER- | ||||
ATURE | 37° C. | 44° C. | ||
SINGLE CAPSULE | |||
External capsule | Slightly | White | white |
yellowish | |||
Content | Mixture of | Mixture of | Mixture of |
white and | white and | white and | |
yellow powder | beige powder | beige powder | |
DOUBLE CAPSULE | |||
External capsule | white | white | white |
Internal capsule | brown | Brown | brown |
Content of the | white powder | white powder | white powder |
External capsule | |||
Content of the | yellow powder | yellow powder | yellow powder |
Internal capsule | |||
External capsule of format | 0+ | ||
containing | |||
bismuth biscalcitrate | 215 mg | ||
metronldazole | 125 mg | ||
Internal capsule of format | 3 | ||
containing | |||
tetracycline hydrochloride | 125 mg | ||
Tetracycline hydrochloride | 125 mg | ||
Gastroprotected omeprazole | 5 mg | ||
Magnesium stearate | 5 mg | ||
Talc | 5 mg | ||
Bismuth biscalcitrate | 215 mg | ||
(corresponding to | |||
53,7 mg of Bismuth) | |||
Metronidazole | 125 mg | ||
Magnesium rate | 5 mg | ||
Talc | 5 mg | ||
Claims (37)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT97MI002788A IT1296980B1 (en) | 1997-12-17 | 1997-12-17 | DOUBLE CAPSULE AS A PHARMACEUTICAL FORM FOR THE ADMINISTRATION OF ACTIVE INGREDIENTS IN MULTIPLE THERAPIES |
ITMI97A2788 | 1997-12-17 | ||
PCT/EP1998/008167 WO1999030693A2 (en) | 1997-12-17 | 1998-12-14 | A double capsule for the administration of active principles in multiple therapies |
Publications (1)
Publication Number | Publication Date |
---|---|
US6350468B1 true US6350468B1 (en) | 2002-02-26 |
Family
ID=11378381
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/581,721 Expired - Lifetime US6350468B1 (en) | 1997-12-17 | 1998-12-14 | Double capsule for the administration of active principles in multiple therapies |
Country Status (26)
Country | Link |
---|---|
US (1) | US6350468B1 (en) |
EP (1) | EP1037614B1 (en) |
JP (1) | JP4615713B2 (en) |
KR (1) | KR100509351B1 (en) |
CN (1) | CN1147292C (en) |
AR (1) | AR014126A1 (en) |
AT (1) | ATE254910T1 (en) |
AU (1) | AU743090B2 (en) |
BR (1) | BR9812803A (en) |
CA (1) | CA2315408C (en) |
CZ (1) | CZ299181B6 (en) |
DE (1) | DE69820108T2 (en) |
DK (1) | DK1037614T3 (en) |
ES (1) | ES2212391T3 (en) |
HK (1) | HK1034897A1 (en) |
HU (1) | HU225690B1 (en) |
ID (1) | ID26340A (en) |
IT (1) | IT1296980B1 (en) |
MY (1) | MY121713A (en) |
NO (1) | NO329126B1 (en) |
NZ (1) | NZ505655A (en) |
PE (1) | PE20000512A1 (en) |
PL (1) | PL192541B1 (en) |
PT (1) | PT1037614E (en) |
TR (1) | TR200001761T2 (en) |
WO (1) | WO1999030693A2 (en) |
Cited By (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030060109A1 (en) * | 2001-09-26 | 2003-03-27 | Joyce Michael J. | Industrial process fabric |
US20030150832A1 (en) * | 2000-07-20 | 2003-08-14 | Massoud Bakhshaee | Delivery device |
US20040105883A1 (en) * | 2001-04-17 | 2004-06-03 | Ping Gao | Pharmaceutical dosage form capable of maintaining stable dissolution profile upon storage |
US20040105885A1 (en) * | 2001-04-17 | 2004-06-03 | Ping Gao | Gelatin capsule exhibiting reduced cross-linking |
US20040131670A1 (en) * | 2001-04-17 | 2004-07-08 | Ping Gao | Pellicle-resistant gelatin capsule |
US20040142036A1 (en) * | 1999-08-18 | 2004-07-22 | Abrams Andrew L. | Metering and packaging of controlled release medication |
WO2004060379A2 (en) * | 2003-01-03 | 2004-07-22 | Milankovits Marton | Pharmaceutical compositions comprising an antibacterial agent nd antifungal agent and a nitroimidazole for the treatment and prevention of genitourinary infections and their extragenital complications |
US20050008690A1 (en) * | 2002-04-10 | 2005-01-13 | Miller Fred H. | Multi-phase, multi-compartment capsular delivery apparatus and methods for using same |
US20050053648A1 (en) * | 2003-09-08 | 2005-03-10 | Chalmers Anne Marie | Medication delivery device |
US20060254580A1 (en) * | 2003-10-21 | 2006-11-16 | Chalmers Anne M | Digestible and volume adjustable multi medication delivery device |
US20070053956A1 (en) * | 2005-09-06 | 2007-03-08 | Feed Pro Ltd. | Food formulation for aquatic animals with integrated targeted delivery of bioactive agents |
US20070087048A1 (en) * | 2001-05-31 | 2007-04-19 | Abrams Andrew L | Oral dosage combination pharmaceutical packaging |
US20070212411A1 (en) * | 2006-03-09 | 2007-09-13 | Abdel Fawzy | Coating capsules with active pharmaceutical ingredients |
WO2007103557A2 (en) | 2006-03-09 | 2007-09-13 | Reliant Pharmaceuticals, Inc. | Coating capsules with active pharmaceutical ingredients |
WO2009042960A1 (en) * | 2007-09-27 | 2009-04-02 | Microdose Technologies, Inc. | Oral dosage combination pharmaceutical packaging |
US20090090361A1 (en) * | 2007-10-09 | 2009-04-09 | Anand Gumaste | Inhalation device |
US20090274766A1 (en) * | 2006-07-25 | 2009-11-05 | Michael Marash | Compositions and Methods For Inhibiting Gastric Acide Secretion Using Derivatives of Small Dicarboxylic Acids in Combination with PPI |
US20100247634A1 (en) * | 2005-05-11 | 2010-09-30 | Aleksey Kostadinov | Compositions and Methods for Inhibiting Gastric Acid Secretion |
US20110111039A1 (en) * | 2005-05-11 | 2011-05-12 | Aleksey Kostadinov | Compositions and Methods for Inhibiting Gastric Acid Secretion |
US20110160156A1 (en) * | 2009-12-31 | 2011-06-30 | Jui-Ming Chou | Pharmaceutical Composition for the Eradication of Helicobacter Pylori and Preparation Method Thereof |
US20110162642A1 (en) * | 2010-01-05 | 2011-07-07 | Akouka Henri M | Inhalation device and method |
US20160008371A1 (en) * | 2014-07-14 | 2016-01-14 | Autotelic Llc | Fixed dose combination for pain relief without edema |
US9700514B1 (en) * | 2014-08-20 | 2017-07-11 | Darren Rubin | Single solid oral dosage forms for treating Helicobacter pylori infection and duodenal ulcer disease |
US20170367976A1 (en) * | 2016-06-22 | 2017-12-28 | University Of Florida Research Foundation, Inc. | Pharmaceutical Capsules For Medication Adherence Monitoring And Methods Of Forming The Same |
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GB0017673D0 (en) * | 2000-07-20 | 2000-09-06 | Mw Encap Limited | Delivery device |
CN100350898C (en) * | 2005-05-23 | 2007-11-28 | 江西本草天工科技有限责任公司 | Diphase capsule of compound notoginseng and preparation method |
CN100350900C (en) * | 2005-05-23 | 2007-11-28 | 江西本草天工科技有限责任公司 | Diphase capsule of compound dalbergia wood and preparation method |
CN100350899C (en) * | 2005-05-23 | 2007-11-28 | 江西本草天工科技有限责任公司 | Diphase capsule of red sage root for coronary heart disease and preparation method |
CA2625776A1 (en) * | 2005-10-14 | 2007-04-26 | Microdose Technologies, Inc. | Pharmaceutical packaging of an oral dosage combination |
CN100393359C (en) * | 2005-12-13 | 2008-06-11 | 济南百诺医药科技开发有限公司 | Multi-element composition for eliminating pylorus spiro-bacillus |
CN101513395B (en) * | 2008-02-20 | 2011-01-12 | 单宝华 | Taxol double-layer soft capsule oral preparation medicament |
DE102009001334B4 (en) | 2009-03-04 | 2017-02-23 | Stefan Brosig | Simple enteric encapsulation, e.g. of ginger and other delicate substances |
CN101607086B (en) * | 2009-07-21 | 2011-11-02 | 山西安特生物制药股份有限公司 | Compound bismuth composition and preparation method thereof |
CN102349887A (en) * | 2011-08-02 | 2012-02-15 | 天津市嵩锐医药科技有限公司 | Diclofenac sodium acetaminophen gastrointestinal type capsule medicinal composition |
ITMI20120350A1 (en) * | 2012-03-06 | 2013-09-07 | Ultimate Italia S A S Di Levantino Enrico E C | DOSAGE FORM FOR ORAL ADMINISTRATION OF ACTIVE PRINCIPLES |
CN105106162A (en) * | 2015-08-21 | 2015-12-02 | 四川百利药业有限责任公司 | Compound tablet for treating ulcer caused by helicobacter pylori and preparation method thereof |
CN108186968B (en) * | 2018-01-08 | 2021-07-20 | 江苏聚荣制药集团有限公司 | Wenweishu capsule |
Citations (26)
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US3072528A (en) | 1957-07-13 | 1963-01-08 | Med Fabrik Chemisch Pharmazeut | Ingestible dry microorganism preparations |
FR1454013A (en) | 1965-08-18 | 1966-07-22 | Pluripharm | Presentation of two combined medicinal products |
DE2729068A1 (en) | 1977-06-28 | 1979-01-11 | Rainer Dr Med Liedtke | Releasing incompatible pharmaceuticals from capsules - by including a second capsule inside the first |
GB2103564A (en) | 1981-08-11 | 1983-02-23 | Ca Minister Nat Defence | Compound capsule |
FR2524311A1 (en) | 1982-04-05 | 1983-10-07 | Azalbert Gilles | Multi:effect medical capsule with compartments contg. different medica - which are ingested simultaneously for programmed release to treat patient |
JPS60193917A (en) | 1984-03-14 | 1985-10-02 | R P Shiila- Kk | Soft capsule of multiplet structure |
US4606909A (en) | 1981-11-20 | 1986-08-19 | A/S Alfred Benzon | Pharmaceutical multiple-units formulation |
US4627808A (en) | 1985-05-31 | 1986-12-09 | Hughes Raymond J | Apparatus for making capsule having plural chambers |
US4642233A (en) | 1982-03-22 | 1987-02-10 | Alza Corporation | Gastrointestinal drug delivery system comprising a hydrogel reservoir containing a plurality of tiny pills |
US4695466A (en) | 1983-01-17 | 1987-09-22 | Morishita Jintan Co., Ltd. | Multiple soft capsules and production thereof |
US4793493A (en) | 1986-09-18 | 1988-12-27 | Makiej Jr Walter J | Multidose capsules |
US4822619A (en) | 1987-02-18 | 1989-04-18 | Ionor, Inc. | Controlled release pharmaceutical preparation containing a gastrointestinal irritant drug |
WO1989003219A1 (en) | 1987-10-12 | 1989-04-20 | Borody Thomas J | Improved method for treatment of gastrointestinal disorders |
US4904476A (en) | 1986-03-04 | 1990-02-27 | American Home Products Corporation | Formulations providing three distinct releases |
US4936461A (en) | 1986-09-18 | 1990-06-26 | Makiej Jr Walter J | Multidose capsules |
WO1992011848A1 (en) | 1991-01-14 | 1992-07-23 | The Procter & Gamble Company | Swallowable pharmaceutical compositions containing colloidal bismuth subcitrate |
US5256684A (en) | 1985-06-13 | 1993-10-26 | The Procter & Gamble Company | Methods and compositions for the treatment of gastrointestinal disorders |
US5310555A (en) | 1992-07-24 | 1994-05-10 | Midwestern Bio-Ag Products And Services, Inc. | Oral nutritional and dietary composition |
US5394980A (en) | 1987-06-30 | 1995-03-07 | Tsai; Min H. | Multicompartment mixing capsule |
US5472695A (en) | 1992-06-25 | 1995-12-05 | Technion Research And Development Foundation Ltd. | Therapeutic application of a thyme extract and in - vitro methods for inhibiting the growth and urease activity of helicobacter pylori |
WO1996002236A1 (en) | 1994-07-20 | 1996-02-01 | Trevor Moore | Improved combination dose unit |
US5501857A (en) | 1992-07-24 | 1996-03-26 | Midwestern Bio-Ag Products & Services, Inc. | Oral nutritional and dietary composition |
US5560912A (en) | 1994-06-27 | 1996-10-01 | Technion Research & Development Foundation Ltd. | Method for inhibiting growth of helicobacter pylori |
US5582837A (en) | 1992-03-25 | 1996-12-10 | Depomed, Inc. | Alkyl-substituted cellulose-based sustained-release oral drug dosage forms |
US5672359A (en) | 1993-07-21 | 1997-09-30 | The University Of Kentucky Research Foundation | Multicompartment hard capsule with control release properties |
US5674858A (en) * | 1991-09-20 | 1997-10-07 | Glaxo Group Limited | Medicaments for treating gastrointestinal disorders |
Family Cites Families (1)
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-
1997
- 1997-12-17 IT IT97MI002788A patent/IT1296980B1/en active IP Right Grant
-
1998
- 1998-12-11 MY MYPI98005603A patent/MY121713A/en unknown
- 1998-12-14 BR BR9812803-5A patent/BR9812803A/en not_active Application Discontinuation
- 1998-12-14 PT PT98966618T patent/PT1037614E/en unknown
- 1998-12-14 JP JP2000538676A patent/JP4615713B2/en not_active Expired - Lifetime
- 1998-12-14 NZ NZ505655A patent/NZ505655A/en not_active IP Right Cessation
- 1998-12-14 TR TR2000/01761T patent/TR200001761T2/en unknown
- 1998-12-14 CZ CZ20002231A patent/CZ299181B6/en not_active IP Right Cessation
- 1998-12-14 WO PCT/EP1998/008167 patent/WO1999030693A2/en active IP Right Grant
- 1998-12-14 ES ES98966618T patent/ES2212391T3/en not_active Expired - Lifetime
- 1998-12-14 AU AU24135/99A patent/AU743090B2/en not_active Expired
- 1998-12-14 KR KR10-2000-7006668A patent/KR100509351B1/en active IP Right Grant
- 1998-12-14 US US09/581,721 patent/US6350468B1/en not_active Expired - Lifetime
- 1998-12-14 AT AT98966618T patent/ATE254910T1/en active
- 1998-12-14 PL PL341737A patent/PL192541B1/en unknown
- 1998-12-14 CA CA002315408A patent/CA2315408C/en not_active Expired - Lifetime
- 1998-12-14 DE DE69820108T patent/DE69820108T2/en not_active Expired - Lifetime
- 1998-12-14 DK DK98966618T patent/DK1037614T3/en active
- 1998-12-14 EP EP98966618A patent/EP1037614B1/en not_active Expired - Lifetime
- 1998-12-14 HU HU0100095A patent/HU225690B1/en unknown
- 1998-12-14 ID IDW20001355A patent/ID26340A/en unknown
- 1998-12-14 CN CNB988130602A patent/CN1147292C/en not_active Expired - Lifetime
- 1998-12-16 AR ARP980106414A patent/AR014126A1/en unknown
- 1998-12-16 PE PE1998001235A patent/PE20000512A1/en not_active IP Right Cessation
-
2000
- 2000-06-16 NO NO20003159A patent/NO329126B1/en not_active IP Right Cessation
-
2001
- 2001-07-27 HK HK01105239A patent/HK1034897A1/en not_active IP Right Cessation
Patent Citations (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3072528A (en) | 1957-07-13 | 1963-01-08 | Med Fabrik Chemisch Pharmazeut | Ingestible dry microorganism preparations |
FR1454013A (en) | 1965-08-18 | 1966-07-22 | Pluripharm | Presentation of two combined medicinal products |
DE2729068A1 (en) | 1977-06-28 | 1979-01-11 | Rainer Dr Med Liedtke | Releasing incompatible pharmaceuticals from capsules - by including a second capsule inside the first |
GB2103564A (en) | 1981-08-11 | 1983-02-23 | Ca Minister Nat Defence | Compound capsule |
US4606909A (en) | 1981-11-20 | 1986-08-19 | A/S Alfred Benzon | Pharmaceutical multiple-units formulation |
US4642233A (en) | 1982-03-22 | 1987-02-10 | Alza Corporation | Gastrointestinal drug delivery system comprising a hydrogel reservoir containing a plurality of tiny pills |
FR2524311A1 (en) | 1982-04-05 | 1983-10-07 | Azalbert Gilles | Multi:effect medical capsule with compartments contg. different medica - which are ingested simultaneously for programmed release to treat patient |
US4695466A (en) | 1983-01-17 | 1987-09-22 | Morishita Jintan Co., Ltd. | Multiple soft capsules and production thereof |
JPS60193917A (en) | 1984-03-14 | 1985-10-02 | R P Shiila- Kk | Soft capsule of multiplet structure |
US4627808A (en) | 1985-05-31 | 1986-12-09 | Hughes Raymond J | Apparatus for making capsule having plural chambers |
US5256684A (en) | 1985-06-13 | 1993-10-26 | The Procter & Gamble Company | Methods and compositions for the treatment of gastrointestinal disorders |
US4904476A (en) | 1986-03-04 | 1990-02-27 | American Home Products Corporation | Formulations providing three distinct releases |
US4793493A (en) | 1986-09-18 | 1988-12-27 | Makiej Jr Walter J | Multidose capsules |
US4936461A (en) | 1986-09-18 | 1990-06-26 | Makiej Jr Walter J | Multidose capsules |
US4822619A (en) | 1987-02-18 | 1989-04-18 | Ionor, Inc. | Controlled release pharmaceutical preparation containing a gastrointestinal irritant drug |
US5394980A (en) | 1987-06-30 | 1995-03-07 | Tsai; Min H. | Multicompartment mixing capsule |
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US5582837A (en) | 1992-03-25 | 1996-12-10 | Depomed, Inc. | Alkyl-substituted cellulose-based sustained-release oral drug dosage forms |
US5472695A (en) | 1992-06-25 | 1995-12-05 | Technion Research And Development Foundation Ltd. | Therapeutic application of a thyme extract and in - vitro methods for inhibiting the growth and urease activity of helicobacter pylori |
US5310555A (en) | 1992-07-24 | 1994-05-10 | Midwestern Bio-Ag Products And Services, Inc. | Oral nutritional and dietary composition |
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US5672359A (en) | 1993-07-21 | 1997-09-30 | The University Of Kentucky Research Foundation | Multicompartment hard capsule with control release properties |
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WO1996002236A1 (en) | 1994-07-20 | 1996-02-01 | Trevor Moore | Improved combination dose unit |
Cited By (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7404968B2 (en) * | 1999-08-18 | 2008-07-29 | Microdose Technologies, Inc. | Metering and packaging of controlled release medication |
US20040142036A1 (en) * | 1999-08-18 | 2004-07-22 | Abrams Andrew L. | Metering and packaging of controlled release medication |
US20030150832A1 (en) * | 2000-07-20 | 2003-08-14 | Massoud Bakhshaee | Delivery device |
US20040105883A1 (en) * | 2001-04-17 | 2004-06-03 | Ping Gao | Pharmaceutical dosage form capable of maintaining stable dissolution profile upon storage |
US20040105885A1 (en) * | 2001-04-17 | 2004-06-03 | Ping Gao | Gelatin capsule exhibiting reduced cross-linking |
US20040131670A1 (en) * | 2001-04-17 | 2004-07-08 | Ping Gao | Pellicle-resistant gelatin capsule |
US20070087048A1 (en) * | 2001-05-31 | 2007-04-19 | Abrams Andrew L | Oral dosage combination pharmaceutical packaging |
US20030060109A1 (en) * | 2001-09-26 | 2003-03-27 | Joyce Michael J. | Industrial process fabric |
US6726809B2 (en) | 2001-09-26 | 2004-04-27 | Albany International Corp. | Industrial process fabric |
US20050008690A1 (en) * | 2002-04-10 | 2005-01-13 | Miller Fred H. | Multi-phase, multi-compartment capsular delivery apparatus and methods for using same |
US8361497B2 (en) | 2002-04-10 | 2013-01-29 | Innercap Technologies, Inc. | Multi-phase, multi-compartment, capsular delivery apparatus and methods for using the same |
US7670612B2 (en) | 2002-04-10 | 2010-03-02 | Innercap Technologies, Inc. | Multi-phase, multi-compartment capsular delivery apparatus and methods for using same |
WO2004060379A3 (en) * | 2003-01-03 | 2004-10-14 | Marton Milankovits | Pharmaceutical compositions comprising an antibacterial agent nd antifungal agent and a nitroimidazole for the treatment and prevention of genitourinary infections and their extragenital complications |
WO2004060379A2 (en) * | 2003-01-03 | 2004-07-22 | Milankovits Marton | Pharmaceutical compositions comprising an antibacterial agent nd antifungal agent and a nitroimidazole for the treatment and prevention of genitourinary infections and their extragenital complications |
US20050053648A1 (en) * | 2003-09-08 | 2005-03-10 | Chalmers Anne Marie | Medication delivery device |
US20060254580A1 (en) * | 2003-10-21 | 2006-11-16 | Chalmers Anne M | Digestible and volume adjustable multi medication delivery device |
US7641916B2 (en) * | 2003-10-21 | 2010-01-05 | Ambo Innovations, Llc | Digestible and volume adjustable multi medication delivery device |
US9132082B2 (en) * | 2005-05-11 | 2015-09-15 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acid secretion |
US9278080B2 (en) | 2005-05-11 | 2016-03-08 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acid secretion |
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US20110250268A1 (en) * | 2005-05-11 | 2011-10-13 | Aleksey Kostadinov | Compositions and Methods for Inhibiting Gastric Acid Secretion |
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