US7226595B2 - Modified Chimeric superantigens and their use - Google Patents
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- US7226595B2 US7226595B2 US10/283,838 US28383802A US7226595B2 US 7226595 B2 US7226595 B2 US 7226595B2 US 28383802 A US28383802 A US 28383802A US 7226595 B2 US7226595 B2 US 7226595B2
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Images
Classifications
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3023—Lung
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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- C—CHEMISTRY; METALLURGY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3046—Stomach, Intestines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C07K2319/00—Fusion polypeptide
Abstract
Description
Region | SEQ ID NO for SEA | SEQ ID NO for SEE |
A | SEQ ID NO.: 9 | SEQ ID NO.: 10 |
B | SEQ ID NO.: 11 | SEQ ID NO.: 12 |
C | SEQ ID NO.: 13 | SEQ ID NO.: 14 |
D | SEQ ID NO.: 15 | SEQ ID NO.: 16 |
E | SEQ ID NO.: 17 | SEQ ID NO.: 18 |
F | SEQ ID NO.: 19 | SEQ ID NO.: 20 |
G | SEQ ID NO.: 21 | SEQ ID NO.: 22 |
H | SEQ ID NO.: 23 | SEQ ID NO.: 24 |
-
- 1. A great impact on the superantigen activity as such and a limited effect on the TCR specificity, in particular on Vβ specificity. For SEA-type superantigens this means region A (SEQ ID NO. 9) (amino acid positions 20–27).
- 2. A profound effect on the specificity with respect to binding to polymorphic TCR chains, such as the Vβ chain. For SEA-type of superantigens this means regions C (SEQ ID NO. 13) (amino acid positions 60–62), F (SEQ ID NO. 19) (amino acid positions 110–126) and H (SEQ ID NO. 23) (
amino acid position 200–207).
Region A: | R20G, N21T, S24G, R27K |
Region C: | G60D, P62S |
Region F: | H111R, H114Q, G115Y, F117Y, G118N, S124V, G126D |
Region H: | D200G, P206S, D207N |
T-B-SA(m)
DAVMTQTPTF LLVSAGDRVT ITC KASQSVS | 50 | (SEQ ID NO 6) |
NDVA WY QQ KP G Q SPTLLISY | ||
TSSRYA |
100 | |
EDLAVFC QQ DYNSPPT FGG GTKLEIK |
TABLE 1 | ||
Proliferation EC50 (pM) | ||
C215Fab-SEAwt | 2.2 | ||
C215Fab-SEEwt | 6.9 | ||
C215Fab-SEE/A-A | 0.9 | ||
C215Fab-SEE/A-C | 2.8 | ||
C215Fab-SEE/A-F | 5.7 | ||
C215Fab-See/A-H | 1.0 | ||
C215Fab-SEE/A-AH | 0.3 | ||
C215Fab-SEA/E-BDEG | 1.6 | ||
TABLE 2 | ||||
I1B3 | 2, |
11,49 | ||
(MuVβ 1) | (MuVβ 3) | (MuVβ 11) | ||
EC50 (nM) | EC50 (nM) | EC50 (nM) | ||
C215Fab- |
10 | 3 | 0.05 | ||
C215Fab- |
10 | >1000 | 0.05 | ||
C215Fab- |
10 | 10 | 0.05 | ||
C215Fab-SEE/A-C | >1000 | >1000 | 0.05 | ||
C215Fab-SEE/A-F | >300 | >300 | 0.05 | ||
C215Fab- |
100 | 3 | 0.3 | ||
C215Fab-SEE/A-AH | 10 | 3 | 0.3 | ||
- Abrahmsén L. et al (1995) Characterization of two distinct MHC Class II binding sites in the superantigen staphylococcal enterotoxin A. EMBO J 14:2978–86.
- Abrahmsén et al (1996) WO961650 (patent application)
- Dohlsten et al (1988) Two subsets of human peripheral blood CD4+ T helper cells differing in the capacity to produce IL-2 and interferon-gamma can be defined by the Leu-18 and UCHL1 monoclonal antibodies. Eur J Immunol 18:1173.
- Dohlsten M et al (1994) Monoclonal antibody-superantigen fusion proteins: Tumor specific agents for T cell based tumor therapy. Proc Natl Acad Sci USA 91:8945–49.
- Dohlsten M et al (1991) Monoclonal antibody-targeted superantigens: A different class of anti-tumor agents. Proc Natl Acad Sci USA 88:9287–91.
- Dohlsten et al (1992) WO920470 (patent application)
- Fleury S et al (1991) Mutational analysis of the interaction between CD4 and class II MHC: class II antigens. Cell 66:1037–49.
- Fraser J D et al (1993) Structural model of Staphylococcal entertoxin A interactions with MHC class II antigens. In: Huber, B T Palmer, E (eds) Current Communications in Cell and
Molecular Biology 7. Cold Spring Harbour Laboratory Press, Cold Spring Harbor, N.Y. - Grossman et al (1991) Mutation of the disulfide loop in staphylococcal enterotoxin A. Consequences for T cell recognition. J Immunol 147:3274–81.
- Hartwig U F et al (1993) Mutations affecting MHC class II binding of the
- Horton R M et al (1990) Gene splicing by overlap extension: tailor-made genes using the polymerase chain reaction. Biotechniques 8:528–35
- Hudson et al (1993) Two adjacent residues in staphylococcal enterotoxins A and E determine T cell receptor V beta specificity. J Exp Med 177:175–84.
- Huffiagle W O et al (1991) The carboxyl-terminal region of staphylococcal enterotoxin type A is required for a fully active molecule. Infect Immun 59:2126–34.
- Irwin M J et al (1992) Entertoxin residues determining T-cell receptor Vb binding specificity. Nature 359:841–3
- Kalland et al (1991) WO9314634 (patent application)
- Kappler J W et al (1992) Mutations defining functional regions of the superantigen staphylococcal enterotoxin B. J Exp Med 175:387–96
- Kappler et al (1993) WO9314634 (patent application)
- Kotzin B L et al (1993) Superantigens and their potential role in human disease. Adv Immunol 54:99–166.
- Kraulis P J (1991) MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures. J Appl Cryst 24:946–50.
- Lando P A et al (1993) Co-stimulation with B7 and targeted superantigen is required for MHC class II-independent T-cell proliferation but not cytotoxicity. Immunology 80: 236–241.
- Lindholm et al (1993) 9301302 (patent application)
- Mollick J A et al (1993) Localization of a site on bacterial superantigens that determines T cell receptor beta chain specificity. J Exp Med 177:283–93.
- Newall et al (1991) In vivo T-cell activation by staphylococcal enterotoxin B prevents outgrowth of a malignant tumor. Proc Natl Acad Sci USA 88 1074–1078
- Schad E M et al (1995) Crystal structure of the superantigen, Staphylococcal enterotoxin type A. EMBO J 14:3292–301.
- Stern et al (1989) WO8907947 (patent application)
- Terman et al (1991) WO9110680 (patent application)
- Terman et al (1989) WO9324136 (patent application)
- Von Heijne, G (1986) A new method for predicting signal sequence cleavage sites. Nucleic Acid Res. 14, 1483–90.
Claims (9)
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Application Number | Priority Date | Filing Date | Title |
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SE9601245A SE9601245D0 (en) | 1996-03-29 | 1996-03-29 | Chimeric superantigens and their use |
SE9601245-5 | 1996-03-29 | ||
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US10/283,838 US7226595B2 (en) | 1996-03-29 | 2002-10-30 | Modified Chimeric superantigens and their use |
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EP (1) | EP0835266B1 (en) |
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PL (1) | PL189696B1 (en) |
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