Búsqueda Imágenes Maps Play YouTube Noticias Gmail Drive Más »
Iniciar sesión
Usuarios de lectores de pantalla: deben hacer clic en este enlace para utilizar el modo de accesibilidad. Este modo tiene las mismas funciones esenciales pero funciona mejor con el lector.

Patentes

  1. Búsqueda avanzada de patentes
Número de publicaciónUS7400929 B2
Tipo de publicaciónConcesión
Número de solicitudUS 11/279,025
Fecha de publicación15 Jul 2008
Fecha de presentación7 Abr 2006
Fecha de prioridad15 Nov 1996
TarifaPagadas
También publicado comoUS6073052, US6321121, US6604004, US7043307, US7761169, US7933659, US8442645, US20060224220, US20080262530, US20100286753, US20110172748, US20130046146, US20130310642
Número de publicación11279025, 279025, US 7400929 B2, US 7400929B2, US-B2-7400929, US7400929 B2, US7400929B2
InventoresBrian D. Zelickson, Robert A. Ganz
Cesionario originalBoston Scientific Scimed, Inc.
Exportar citaBiBTeX, EndNote, RefMan
Enlaces externos: USPTO, Cesión de USPTO, Espacenet
Device and method for treatment of gastroesophageal reflux disease
US 7400929 B2
Resumen
A lower esophageal sphincter tightening device for treating gastroesophageal reflux disease which includes an insertion device, an energy source, and an energy transmitting device. The insertion device, by insertion through a body opening, positions the energy transmitting device in the proximity of the lower esophageal sphincter. The energy source generates and transmits energy via the insertion device to the energy transmitting device which directs the transmitted energy onto the lower esophageal sphincter which is comprised largely of collagen. The energy source transmits energy at a level sufficient to cause heating of the sphincter's collagen resulting in a shrinkage of the collagen and a tightening of the sphincter.
Imágenes(4)
Previous page
Next page
Reclamaciones(30)
1. A medical treatment system, comprising:
an elongate insertion device configured for insertion through a natural opening in a body;
an energy source coupled to a proximal end of the insertion device; and
an energy transmitting device located at a distal end of the insertion device, the energy transmitting device electrically connected to the energy source trough the insertion device and comprising an expandable portion, and an antenna located on an exterior surface of the expandable portion, the antenna configured to transmit energy generated by the energy source to a target tissue region in the body, the distal end of the insertion device controllable to position the energy transmitting device in relation to the target tissue region,
wherein the insertion device comprises an observation port in communication with an interior lumen extending through the insertion device, wherein a position of the energy transmitting device may be viewed through the observation port.
2. The system of claim 1, further comprising an eye-piece coupled to a proximal end of the observation port.
3. The system of claim 1, further comprising a light source.
4. The system of claim 3, further comprising an optical cable coupled to the light source and extending through the insertion device, the optical cable having a distal end positioned to illuminate an interior body region located proximate the distal end of the insertion device.
5. The system of claim 4, wherein the optical cable comprises a fiber optic bundle.
6. The system of claim 4, wherein the optical cable extends through an interior lumen of the insertion device that is different from the interior lumen in communication with the observation port.
7. The system of claim 1, further comprising a cooling system that cools the expandable portion of the energy transmitting device.
8. The system of claim 7, wherein the expandable portion comprises a balloon, and wherein the cooling system comprises a coolant used to inflate the balloon.
9. The system of claim 8, wherein the coolant is selected from the group comprising air, liquid, and gel.
10. A method of treating body tissue, comprising:
inserting an elongate insertion device through a natural body opening and into a natural body passage until an energy transmitting device located at a distal end of the insertion device is positioned adjacent a target tissue region, the energy transmitting device comprising an expandable portion and an antenna located on an exterior surface of the expandable portion;
expanding the expandable portion of the energy transmitting device so that the antenna is in electrical communication with the target tissue region;
viewing the energy transmitting device through an observation port of the insertion device in communication with an interior lumen extending through the insertion device;
coupling an energy source to the insertion device, wherein the antenna in electrical communication with the energy source when the energy source is coupled to the insertion device; and
delivering energy from the energy source through the antenna to the target tissue region.
11. The method of claim 10, wherein the energy transmitting device is viewed through an eye-piece coupled to a proximal end of the observation port.
12. The method of claim 10, further comprising illuminating a region of the body passage located proximate the distal end of the insertion device using a light source coupled to the insertion device.
13. The method of claim 12, wherein the light source is coupled to an optical cable extending through the insertion device.
14. The method of claim 13, wherein the optical cable comprises a fiber optic bundle.
15. The method of claim 13, wherein the optical cable extends through an interior lumen of the insertion device that is different from the interior lumen in communication with the observation port.
16. The method of claim 10, further comprising cooling the expandable portion of the energy transmitting device to thereby cool a surface of the body passage through which the energy is delivered.
17. The method of claim 16, wherein the expandable portion of the energy delivery device is an inflatable balloon, and wherein cooling the expandable portion comprises using a coolant to inflate the balloon.
18. The method of claim 17, wherein the coolant is selected from the group comprising air, liquid, and gel.
19. A medical treatment system, comprising:
an elongate insertion device configured for insertion through a natural opening of a body;
an energy source coupled to a proximal end of the insertion device;
an energy transmitting device located at a distal end of the insertion device, the energy transmitting device electrically connected to the energy source through the insertion device and comprising an expandable portion and an antenna located on an exterior surface of the expandable portion, the antenna configured to transmit energy generated by the energy source to a target tissue region in the body, wherein the distal end of the insertion device is controllable to position the energy transmitting device in relation to the target tissue region; and
a cooling system that cools the expandable portion of the energy transmitting device.
20. The system of claim 19, wherein the expandable portion comprises a balloon, and wherein the cooling system comprises a coolant used to inflate the balloon.
21. The system of claim 20, wherein the coolant is selected from the group comprising air, liquid, and gel.
22. A medical treatment system, comprising:
an elongate insertion device configured for insertion through a natural opening of a body;
an energy source coupled to a proximal end of the insertion device;
an energy transmitting device located at a distal end of the insertion device, the energy transmitting device electrically connected to the energy source through the insertion device and comprising an expandable portion and an antenna located on an exterior surface of the expandable portion, the antenna configured to transmit energy generated by the energy source to a target tissue region in the body, the distal end of the insertion device controllable to position the energy transmitting device in relation to the target tissue region; and
cooling means for cooling the expandable portion of the energy transmitting device.
23. The system of claim 22, wherein the expandable portion comprises a balloon, and wherein the cooling means comprises a coolant used to inflate the balloon.
24. The system of claim 23, wherein the coolant is selected from the group comprising air, liquid, and gel.
25. A method of treating body tissue, comprising:
inserting an elongate insertion device through a natural opening in a body and into a natural body passage until an energy transmitting device at a distal end of the insertion device is positioned adjacent a target tissue region in the body, the energy transmitting device comprising an expandable portion and an antenna located on an exterior surface of the expandable portion, the distal end of the insertion device controllable to position the energy transmitting device in relation to the target tissue region;
expanding the expandable portion of the energy transmitting device so that the antenna is in electrical communication with the target tissue region;
coupling an energy source to the insertion device, wherein the antenna in electrical communication with the energy source when the energy source is coupled to the insertion device;
delivering energy through the antenna to the target tissue region; and
cooling the expandable portion of the energy transmitting device to thereby cool a surface of the body passage through which the energy is delivered.
26. The method of claim 25, wherein the expandable portion of the energy delivery device is an inflatable balloon, and wherein cooling the expandable portion comprises using a coolant to inflate the balloon.
27. The method of claim 26, wherein the coolant comprises cooled air.
28. The method of claim 26, wherein the coolant comprises cooled liquid.
29. The method of claim 26, wherein the coolant comprises cooled gel.
30. The method of claim 26, wherein an amount and a temperature of the coolant are selected such that the temperature of the body passage surface is cooled sufficiently to dissipate heat build-up therein, while allowing for heat generation is tissue underlying the body passage surface.
Descripción
RELATED APPLICATION DATA

This application is a continuation of U.S. application Ser. No. 10/633,820, filed Aug. 4, 2003, now U.S. Pat. No. 7,043,307, which is a continuation of U.S. application Ser. No. 09/971,315, filed Oct. 4, 2001, now U.S. Pat. No. 6,604,004, which is a divisional of U.S. application Ser. No. 09/475,580, filed Dec. 30, 1999, now U.S. Pat. No. 6,321,121, which is a continuation of 08/749,723 filed Nov. 15, 1996, now U. S. Pat. No. 6,073,052, which are hereby incorporated by reference in their entirety.

BACKGROUND OF THE INVENTION

The invention pertains to the treatment of gastroesophageal reflux disease (GERD).

GERD is a major health problem in the United States and worldwide. It affects tens of millions of people and costs billions of dollars to treat. GERD is the reflux of gastric contents from a stomach into a lower area of an esophagus. The gastric contents include acid secreted by the stomach which causes discomfort and eventual damage to an inner lining of the esophagus if left untreated.

The gastric contents are normally prevented from entering the esophagus by a lower esophageal sphincter (LES) mechanism. The LES is a physiologic, non-anatomic area involving the lower 3 centimeters of the esophagus and like other smooth muscle sphincters in the body, anal or urinary, it is tonically contracted to prevent reflux. A healthy LES opens for a brief period of several seconds in response to swallowing to allow the passage of food. It then quickly regains its tone when the food has passed.

GERD occurs when the sphincter mechanism of the LES fails to work properly. Generally, GERD takes one of three forms: (i) complete weakness of the sphincter musculature in response to a hiatal hernia or an intrinsic weakness that occurs commonly resulting in free reflux, which is poorly understood; (ii) partial weakness of the sphincter that allows reflux when stressed such as a Valsalva maneuver, or (iii) transient or sudden inappropriate relaxation of an otherwise normally toned sphincter.

Treatment of a weakened or inappropriately relaxing sphincter can be either medical or surgical. Known medical treatments include measures or medication that attempt to decrease acid secretion, increase gastric emptying or strengthen the LES. However, the medications are expensive and the measures typically have to be continued on a life long basis.

A more permanent treatment method for GERD can be performed surgically. Surgical methods attempt to strengthen the LES by incising the stomach and wrapping a portion of the stomach around the lower section of the esophagus. This technique is known as a fundoplication. However, surgical treatment requires longer post treatment care, increased pain and recovery time, as well as the associated risks with any surgical procedure.

The latest developments for treating GERD have attempted to provide a minimally invasive procedure to strengthen the lower esophageal area. One such treatment is disclosed by C. P. Swain et al, Knot Tying At Flexible Endoscopy, Gastrointestinal Endoscopy, 1994; 40:722-29, that calls for endoscopic sewing in the lower esophageal area. However the sewn portion of the esophagus in the Swain technique may relax again requiring further or alternate forms of treatment. Another technique disclosed by Donahue injects noxious, scarring substances into the lower esophageal area to create a fibrous reaction P. E. Donahue, et. al., Endoscopic Ultrasonography Verifies Effect On Endoscopic Treatment Of Reflux In Dogs And Man, Surgical Endoscopy, 1993;7:524-28. However, the Donahue technique may require numerous and repeated injections.

The esophagus and LES are composed of three tissue layers; a mucosa or inner layer, a submucosa or middle layer, and a muscle or an outer layer. The submucosa layer is largely composed of collagen. It is well-known that heating of collagen tissue within an appropriate temperature range results in a tightening or shrinkage of the collagen tissue. However, there exists no known device or technique for strengthening the LES by shrinkage of collagen tissue as a means to treat GERD.

SUMMARY OF THE INVENTION

The invention discloses a device and method to prevent gastroesophageal reflux or GERD. The device comprises an insertion device, an energy source, and an energy transmitting device. The insertion device has a proximal end connected to the energy source and a distal end connected to the energy transmitting device. The energy source generates and transmits energy to the energy transmitting device through the insertion device. The energy transmitting device then radiates and directs the transmitted energy onto a target area. The insertion device positions the energy transmitting device in the proximity sit of a lower esophageal sphincter, such that the sphincter tissue becomes the target area of the energy transmitting device.

The energy source then generates and transmits energy to the energy transmitting device which radiates the energy onto the sphincter tissue. The sphincter tissue absorbs the radiated energy which generates heat within the sphincter tissue. The sphincter tissue is largely comprised of collagen which exhibits shrinkage when heated.

The energy source generates and transmits energy at a level sufficient to cause heating of the sphincter tissue to a temperature of between 50° C. and 70° C. preferably between 63° C. and 65° C.) within a time period of between about 1 microsecond and 1 minute. Heating the sphincter tissue within the appropriate range achieves sufficient collagen shrinkage to tighten the lower esophageal sphincter and prevent reflux.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a perspective view of a lower esophageal sphincter tightening device of the present invention.

FIG. 2 is a cutaway diagram of an esophagus.

FIG. 3 is a perspective view of a second embodiment of the lower esophageal sphincter tightening device of the present invention.

FIG. 4 is a perspective view of a third embodiment of the lower esophageal sphincter tightening device of the present invention.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

In FIG. 1, a preferred embodiment of a lower esophageal sphincter (LES) tightening device 10 is shown in use. The LES tightening device 10 comprises an insertion device 12, an energy source 14 and an energy transmitting device 16. As shown in FIG. 1, the LES tightening device 10 could also include an inflation device 18 and a balloon 20.

In a preferred embodiment, the insertion device 12 is an endoscope as shown in FIGS. 1, 3 and 4. However, workers skilled in the art will recognize that a catheter or other similar device could also be used. As shown in FIG. 1, the insertion device 12 has a proximal end 22 and a distal end 24. Additionally, the insertion device 12 could include an, eye piece 26, a light source 28 and a control means 30. A series of ports 32 provide access from the proximal end 22 to the distal end 24 through lumens located within the interior of the insertion device 12 along its longitudinal access.

The energy source 14 is located at the proximal end 22 of the insertion device 12. The energy source 14 generates and transmits energy to the energy transmitting device 16 located at the distal end 24 of the insertion device 12. The energy source 14 is connected to the energy transmitting device 16 by a transmission line 34 which passes rough a manifold 36. Within the manifold 36, the transmission line 34 becomes part of a catheter 38 that is fed though one of the ports 32 at the proximal end 22. The catheter 38 then passes down one of the interior lumens of the insertion device 12 and is connected to the energy transmitting device 16 at the distal end 24.

In a preferred embodiment, the insertion device 12 enters a body opening 40 and passes down an esophagus 42 until the distal end 24 is in the proximity of a lower esophageal sphincter 44. The control means 30 aid in positioning the distal end 24 of the insertion device 12. Observation through eye piece 26 insures proper placement of the distal end 24. Observation is enabled by the light source 28 which illuminates the area surrounding the distal end 24 by light transmitted through an optical cable 45 which passes through one of the ports 32 and down another interior lumen. The optical cable 45 is preferably a fiber optic bundle.

The energy transmitting device 16 radiates and directs energy received though the catheter 38 from the energy source 14 onto a target area. The distal end 24 of the insertion device 12 is therefore located such that the target area of the energy transmitting device 16 is directed at tissue comprising the lower esophageal sphincter 44. Once the energy transmitting device 16 is properly positioned, the energy source 14 can transmit energy it has generated to the energy transmitting device 16 through the catheter 38.

The transmitted energy is then radiated and directed by the energy transmitting device 16 onto the lower esophageal sphincter 44 tissue. The lower esophageal sphincter 44 tissue absorbs the energy resulting in the generation of heat within the tissue due to thermal conduction. The lower esophageal sphincter 44 tissue is comprised largely of collagen which will exhibit shrinkage characteristics over an appropriate time temperature relationship prior to being damaged or destroyed.

The appropriate time period to satisfy the time temperature relationship is dependent upon the temperature of the treated tissue, which in turn is dependent upon the level of energy generated in the energy source 14 and radiated by the energy transmitting device 16. The desired tissue temperature in the target area is between 50° C. and 70° C., with a preferred level between 63° C. and 65° C. This temperature increase can be achieved within a period of time between one microsecond and one minute dependent upon the amount and type of energy generated with one energy source 14. In a preferred embodiment, the energy source 14 generates radiant energy (e.g. RF or microwave electromagnetic energy) which is transmitted by a transmission line 34 (such as a coaxial cable) that is then contained within the catheter 38 and connects to the energy transmitting device 16. The energy transmitting device 16 is preferably an antenna or a directional antenna.

The LES tightening device 10 can additionally include the inflation device 18 and the balloon 20. Once the energy transmitting device 16 is properly positioned, the balloon 20 is located at the distal end 24 of the insertion device 12 and encapsulates the energy transmitting device 16 as shown in FIG. 1. The inflation device 18, located at the proximal end 22, inflates or deflates the balloon 20 via a conduit 48. The conduit 48 connects the inflation device 18 to the balloon 20 by passing through the manifold 36, wherein the conduit 48 becomes part of the catheter 38. Air, fluid or gel could be used by the inflation device 18 to inflate the balloon 20. The size of the balloon 20 can be adjusted to maintain proper placement of the energy transmitting device 16 in relation to the lower esophageal sphincter 44 tissue and/or control the amount of collagen shrinkage and therefore control the amount of sphincter tightening.

In a preferred embodiment, the balloon 20 can be either a noncompliant balloon or a compliant balloon. The size of a compliant balloon can be controlled by observation through the eye piece 26, injection of a radiopaque fluid such as fluorochrome into the balloon 20 and viewing on a fluoroscope, or monitoring the pressure of the balloon 20.

FIG. 2 is a cutaway schematic view (not to scale) of the tissue comprising the lower esophageal sphincter 44. The tissue is comprised of three layers; a mucosa 48 inner layer, a submucosa 50 middle layer and a muscle 52 outer layer. In a preferred embodiment, collagen tissue in the submucosa 50 is targeted for shrinkage. In addition, a cooling means to prevent damage to the mucosa 48 may be incorporated into the LES tightening device 10. This can be accomplished by cooling or cycling through cooled air, liquid, or gel to inflate the balloon 20. The cooled material dissipates the heat generated by absorption of the radiated energy from the energy transmitting device 16. This maintains a safe temperature level in the mucosa 46 (which is less than about 50° C. or preferably less than 45° C.) The type and amount of cooled material used to innate the balloon 20 is dependent on the amount and type of energy generated within the energy source 14.

FIG. 3 shows a second embodiment of the LES tightening device 10. Reference numerals identical to those employed in connection with FIG. 1 indicate identical elements, and reference numerals followed by a suffix indicate modified but similar elements. In this preferred embodiment, the energy transmitting device 16A is attached to the outer surface of the balloon 20A to direct energy at the lower esophageal sphincter 44 tissue. As previously described, once the distal end 24 of the insertion device 12 properly positions the energy transmitting device 16A over the lower esophageal sphincter 44 tissue, the balloon 20A can be inflated and the energy source 14 can transmit energy to the energy transmitting device 16A for radiation onto the lower esophageal sphincter 44 tissue. Again, a coolant can be used to inflate the balloon 20A to prevent damage to the mucosa 48 while achieving collagen shrinkage in the submucosa 50 resulting in the tightening of the lower esophageal sphincter 44.

A third alternative embodiment to the present invention is depicted in FIG. 4. Again, reference numerals identical to those employed in connection with FIG. 1 indicate identical elements, and reference numerals followed by a suffix indicate modified but similar elements. In this embodiment, the balloon 20B is enlarged to protrude into a stomach 46 and anchor or retain the energy transmitting device 16B in proper position with respect to the lower esophageal sphincter 44 tissue. In this embodiment, the insertion device 12 positions the energy transmitting device 16B such that the target area comprises the lower esophageal sphincter 44 tissue. Once in place, the balloon 20B is enlarged by injection of a suitable material which retains the position of the energy transmitting device 16B relative to the lower esophageal sphincter 44. This assures the energy radiated by the energy transmitting device 16B is absorbed by the lower esophageal sphincter 4. Again, the material injected into the balloon 20B for inflation can be cooled to a sufficient level to offset and dissipate any heat build-up in the mucosa 48 and thereby enable tile generation of heat and consequent shrinkage of collagen in the submucosa 50.

Although the present invention has been described with reference to treatment of GERD by toning the muscular LES sphincter, workers skilled in the art will recognize that this device and method could be used to shrink or tone other sphincters located in the body to overcome other medical ailments caused by the loss of sphincter muscle tone. For example, the device and method can be used on the urinary or sphincter to overcome incontinence.

Furthermore, workers skilled in the art will also recognize that changes may be made in form and detail without departing from the spirit and scope of the invention. For example, the energy source can generate energy of various wavelengths within the electromagnetic spectrum including but not limited to laser, RF, or microwave energy. Alternatively the energy source can generate ultrasonic energy to generate heat in the targeted tissue, area. The insertion device can be an endoscope, catheter or similar type of device. Depending on the form and wavelength of the energy being used, the energy transmitting device may be an antenna, an ultrasonic transducer, a fiber optic bundle, or an electrical resistance heater. Furthermore, a directional antenna can be used to limit and control the amount of energy directed at specific locations within the targeted tissue.

With the present invention, tissue within the lower esophageal sphincter can be toned or tightened to treat gastroesophageal reflux disease on an outpatient basis with a safe, simple procedure with decreased aftercare, treatment and pain.

Citas de patentes
Patente citada Fecha de presentación Fecha de publicación Solicitante Título
US431115423 Mar 197919 Ene 1982Rca CorporationNonsymmetrical bulb applicator for hyperthermic treatment of the body
US43265295 Dic 197927 Abr 1982The United States Of America As Represented By The United States Department Of EnergyCorneal-shaping electrode
US438100730 Abr 198126 Abr 1983The United States Of America As Represented By The United States Department Of EnergyMultipolar corneal-shaping electrode with flexible removable skirt
US46129409 May 198423 Sep 1986Scd IncorporatedMicrowave dipole probe for in vivo localized hyperthermia
US464673713 Jun 19833 Mar 1987Laserscope, Inc.Localized heat applying medical device
US4662383 *23 Sep 19835 May 1987Kureha Kagaku Kogyo Kabushiki KaishaEndotract antenna device for hyperthermia
US470969814 May 19861 Dic 1987Thomas J. FogartyHeatable dilation catheter
US500743719 Abr 199016 Abr 1991Mmtc, Inc.Catheters for treating prostate disease
US507484024 Jul 199024 Dic 1991Inbae YoonPacking device and method of packing for endoscopic procedures
US5103804 *3 Jul 199014 Abr 1992Boston Scientific CorporationExpandable tip hemostatic probes and the like
US522092715 Mar 199022 Jun 1993Bsd Medical CorporationUrethral inserted applicator for prostate hyperthermia
US52772011 May 199211 Ene 1994Vesta Medical, Inc.Endometrial ablation apparatus and method
US530416917 Ago 199219 Abr 1994Laser Biotech, Inc.Method for collagen shrinkage
US534855123 Mar 199320 Sep 1994Kerus Medical SystemsMethod for correcting refractive disorders
US536439016 Abr 199215 Nov 1994Refractive Laser Research And Development, Inc.Handpiece and related apparatus for laser surgery and dentistry
US537426123 Oct 199020 Dic 1994Yoon; InbaeMultifunctional devices for use in endoscopic surgical procedures and methods-therefor
US53742656 Ago 199220 Dic 1994Laser Biotech, Inc.Collagen treatment apparatus and method
US54376587 Oct 19921 Ago 1995Summit Technology, IncorporatedMethod and system for laser thermokeratoplasty of the cornea
US544346316 Ago 199322 Ago 1995Vesta Medical, Inc.Coagulating forceps
US544347014 Abr 199322 Ago 1995Vesta Medical, Inc.Method and apparatus for endometrial ablation
US544899015 Feb 199412 Sep 1995Very Inventive Physicians, Inc.Endoscope viewing cannula and surgical techniques
US54585966 May 199417 Oct 1995Dorsal Orthopedic CorporationMethod and apparatus for controlled contraction of soft tissue
US548443214 Abr 199416 Ene 1996Laser Biotech, Inc.Collagen treatment apparatus
US549627116 Jun 19935 Mar 1996American Medical Systems, Inc.Combined hyperthermia and dilation catheter
US550573024 Jun 19949 Abr 1996Stuart D. EdwardsThin layer ablation apparatus
US55099296 Oct 199223 Abr 1996Technomed Medical SystemsUrethral probe and apparatus for the therapeutic treatment of the prostate by thermotherapy
US55406791 Jul 199430 Jul 1996Boston Scientific CorporationDevice and method for heating tissue in a patient's body
US55586724 Ago 199424 Sep 1996Vidacare, Inc.Thin layer ablation apparatus
US55627206 Oct 19948 Oct 1996Vesta Medical, Inc.Bipolar/monopolar endometrial ablation device and method
US55692417 Jul 199429 Oct 1996Vidacare, Inc.Thin layer ablation apparatus
US55757886 Oct 199419 Nov 1996Stuart D. EdwardsThin layer ablation apparatus
US562048020 Sep 199415 Abr 1997Urologix, Inc.Method for treating benign prostatic hyperplasia with thermal therapy
US565827831 Ene 199519 Ago 1997Cardiac Pathways, Inc.Catheter for RF ablation with cooled electrode and method
US5665064 *12 May 19959 Sep 1997Sherwood Medical CompanyGastroenteric feeding tube for endoscopic placement and method of use
US589113424 Sep 19966 Abr 1999Goble; ColinSystem and method for applying thermal energy to tissue
US591624130 Jul 199729 Jun 1999Urologix, Inc.Device and method for asymmetrical thermal therapy with helical dipole microwave antenna
US596475511 Oct 199612 Oct 1999Vioacare International, Inc.Thin layer ablation apparatus
US600675519 Feb 199828 Dic 1999Edwards; Stuart D.Method to detect and treat aberrant myoelectric activity
US6073052 *15 Nov 19966 Jun 2000Zelickson; Brian D.Device and method for treatment of gastroesophageal reflux disease
US627708931 Mar 199821 Ago 2001Inbae YoonMethod for ablating portions of the uterus
US6604004 *4 Oct 20015 Ago 2003Brian D. ZelicksonDevice and method for treatment of gastroesophageal reflux disease
US7043307 *4 Ago 20039 May 2006Boston Scientific Scimed, Inc.Device and method for treatment of gastroesophageal reflux disease
EP0422112B127 Jun 19897 Feb 1996Trustees Of Dartmouth CollegeCombined microwave heating and surface cooling of the cornea
Otras citas
Referencia
1Fitzpatrick et al., "Pulsed Carbon Dioxide Laser Resurfacing of Photoaged Facial Skin," Arch Dermatol, Apr. 1996, vol. 132. pp. 395-401.
2Hayashi et al., "The Effect of Non-Ablative Laser Energy on Joint Capsular Properties: An In Vitro Mechanical Study using a Rabbit Model," Comparative Orthopaedic Research Laboratory, University of Wisconsin-Madison, Mar. 1994, pp. 1-22.
3Hayashi et al., "The Effect of Non-Ablative Laser Energy on the Ultrastructure of Joint Capsular Collagen," Comparative Orthopaedic Research Laboratory, University of Wisconsin-Madison, Jan. 1995, pp. 1-22.
4Hruza et al., "Laser Skin Resurfacing," Arch Dermatol, Apr. 1996, vol. 132, pp. 451-455.
5R.C.M. McGouran, MD and J.M. Galloway, MD "A laser-induced scar at the cardia increases the yield pressure of the lower esophageal sphincter". Gastrointestinal Endoscopy, vol. 36, pp. 439-443, Nov. 5, 1990.
6Zhou et al., Thermal Modeling of Laser Photo Thermo Keratoplasty (LPTK), Ophthalmic Technologies II, 1992, SPIE vol. 1644, pp. 81-133.
Citada por
Patente citante Fecha de presentación Fecha de publicación Solicitante Título
US7761169 *10 Jun 200820 Jul 2010Boston Scientific Scimed, Inc.Device and method for treatment of gastroesophageal reflux disease
US7933659 *19 Jul 201026 Abr 2011Boston Scientific Scimed, Inc.Device and method for treatment of gastroesophageal reflux disease
US820903418 Dic 200826 Jun 2012Electrocore LlcMethods and apparatus for electrical stimulation treatment using esophageal balloon and electrode
US840165027 Feb 200919 Mar 2013Electrocore LlcMethods and apparatus for electrical treatment using balloon and electrode
US8442645 *24 Mar 201114 May 2013Boston Scientific Scimed, Inc.Device and method for treatment of gastroesophageal reflux disease
US20110172748 *24 Mar 201114 Jul 2011Zelickson Brian DDevice and Method for Treatment of Gastroesophageal Reflux Disease
Clasificaciones
Clasificación de EE.UU.607/101, 606/28, 607/116, 607/133
Clasificación internacionalA61B18/18, A61B18/08, A61B18/14, A61B18/00
Clasificación cooperativaA61B18/08, A61B1/018, A61B18/1492, A61B1/00082, A61B18/20, A61B2018/00011, A61B2018/00214, A61B2018/00553, A61B18/1815
Clasificación europeaA61B18/14V, A61B18/08
Eventos legales
FechaCódigoEventoDescripción
23 Sep 2011FPAYFee payment
Year of fee payment: 4
12 Feb 2010ASAssignment
Owner name: BOSTON SCIENTIFIC SCIMED, INC.,MINNESOTA
Free format text: CHANGE OF NAME;ASSIGNOR:SCIMED LIFE SYSTEMS, INC.;US-ASSIGNMENT DATABASE UPDATED:20100218;REEL/FRAME:23950/262
Effective date: 20041222
Free format text: CHANGE OF NAME;ASSIGNOR:SCIMED LIFE SYSTEMS, INC.;REEL/FRAME:023950/0262
29 Dic 2009CCCertificate of correction