US7846321B2 - Error detection in analyte measurements based on measurement of system resistance - Google Patents
Error detection in analyte measurements based on measurement of system resistance Download PDFInfo
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- US7846321B2 US7846321B2 US11/874,766 US87476607A US7846321B2 US 7846321 B2 US7846321 B2 US 7846321B2 US 87476607 A US87476607 A US 87476607A US 7846321 B2 US7846321 B2 US 7846321B2
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- potential
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3274—Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration
Abstract
Description
-
- It is generally desirable in electrochemical test strips to utilize a small volume sample. Because these tests may be performed with considerable frequency, it is desirable to utilize disposable, single use test strips and to minimize the per strip cost. These desires favor less precise manufacturing methods. At the same time, there is a conflicting desire for use of the smallest possible sample volume, and determinations of sufficient accuracy and precision to be useful. It would therefore be useful to be able to make corrections for multiple variations in the quality of the strip based on measurements made at the time of use, or to reject strips that are too far outside acceptable parameters. It would further be desirable to make these corrections or to reject strips based upon one or at most a small number of measured parameters.
1/I2∝t
where I is the current and t is time. Cottrell analysis can be utilized to determine glucose concentration as described in U.S. Pat. Nos. 5,243,516; 5,352,351 and 6,284,125. Commonly assigned U.S. patent application Ser. No. 10/907,803, filed Apr. 15, 2005, which is incorporated herein by reference, discloses a Cottrell analysis of analyte concentration that includes a mobility correction obtained when the applied potential is switched off after monitoring the current to obtain data for determination of analyte.
V drop =V app −V elect.
Non-linear fits might also be used if this provides a better model for a particular strip geometry.
The use of a plurality of cycles results in improved accuracy since the significance of anomalous readings is reduced by averaging. On the other hand, each cycle takes time, especially if a given device requires time for the current to settle after re-application of the potential, and therefore increases the amount of time it takes to achieve a result for display to a user. The number of cycles used is therefore a compromise between these two factors. In general, suitable numbers of cycles are 2, 3, 4 or 5. The number of cycles may also be determined dynamically based on the observed variance in the switching cycles already evaluated. Thus, if the first two or three cycles produce essentially the same value for Vdrop it may be dynamically determined that this is a sufficient number of cycles.
Medians and averages omitting outlines may also be used rather than arithmetic averages of all values. The determined value of Rtrack is then compared to a predetermined range (which may be open-ended) and the reading is rejected if the value falls outside the range.
Claims (10)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
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US11/874,766 US7846321B2 (en) | 2006-10-18 | 2007-10-18 | Error detection in analyte measurements based on measurement of system resistance |
US12/961,654 US8192610B2 (en) | 2006-10-18 | 2010-12-07 | Error detection in analyte measurements based on measurement of system resistance |
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US86200206P | 2006-10-18 | 2006-10-18 | |
US11/874,766 US7846321B2 (en) | 2006-10-18 | 2007-10-18 | Error detection in analyte measurements based on measurement of system resistance |
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US12/961,654 Continuation US8192610B2 (en) | 2006-10-18 | 2010-12-07 | Error detection in analyte measurements based on measurement of system resistance |
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US20080093227A1 US20080093227A1 (en) | 2008-04-24 |
US7846321B2 true US7846321B2 (en) | 2010-12-07 |
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US12/961,654 Active US8192610B2 (en) | 2006-10-18 | 2010-12-07 | Error detection in analyte measurements based on measurement of system resistance |
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WO (1) | WO2008049074A2 (en) |
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US9754708B2 (en) | 2011-07-29 | 2017-09-05 | Roche Diabetes Care, Inc. | Encoded biosensors and methods of manufacture and use thereof |
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2007
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- 2007-10-18 WO PCT/US2007/081830 patent/WO2008049074A2/en active Application Filing
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2010
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8888973B2 (en) | 2011-07-29 | 2014-11-18 | Roche Diagnostics Operations, Inc. | Encoded biosensors and methods of manufacture and use thereof |
US9267911B2 (en) | 2011-07-29 | 2016-02-23 | Roche Diabetes Care, Inc. | Encoded biosensors and methods of manufacture and use thereof |
US9754708B2 (en) | 2011-07-29 | 2017-09-05 | Roche Diabetes Care, Inc. | Encoded biosensors and methods of manufacture and use thereof |
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Publication number | Publication date |
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US20110073496A1 (en) | 2011-03-31 |
US20080093227A1 (en) | 2008-04-24 |
WO2008049074A2 (en) | 2008-04-24 |
US8192610B2 (en) | 2012-06-05 |
WO2008049074A3 (en) | 2008-06-05 |
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