|Número de publicación||US8041431 B2|
|Tipo de publicación||Concesión|
|Número de solicitud||US 12/350,080|
|Fecha de publicación||18 Oct 2011|
|Fecha de presentación||7 Ene 2009|
|Fecha de prioridad||7 Ene 2008|
|También publicado como||US20090177251|
|Número de publicación||12350080, 350080, US 8041431 B2, US 8041431B2, US-B2-8041431, US8041431 B2, US8041431B2|
|Inventores||Paul Huelskamp, Thomas J. Harris, Binh C. Tran, Ramprasad Vijayagopal|
|Cesionario original||Cardiac Pacemakers, Inc.|
|Exportar cita||BiBTeX, EndNote, RefMan|
|Citas de patentes (119), Citada por (2), Clasificaciones (7), Eventos legales (2)|
|Enlaces externos: USPTO, Cesión de USPTO, Espacenet|
This non-provisional patent application claims priority under 35 U.S.C. §119(e) to U.S. Provisional Patent application Ser. No. 61/019,549, filed Jan. 7, 2008, the disclosure of which is incorporated by reference.
The invention relates in general to oscillator trimming and, specifically, to a system and method for in situ trimming of oscillators in a pair of implantable medical devices.
Implantable medical devices (IMDs) can provide in situ physiological data monitoring and therapy delivery, including cardiac defibrillation, pacing and resynchronization, and intracorporeal drug delivery. IMDs function through pre-programmed control over monitoring and therapeutic functions. As required, IMDs can be interfaced to external devices, such as programmers, repeaters, and similar devices, which can program, troubleshoot, and exchange parametric and physiological data through induction or other forms of wireless telemetry.
Implantable sensors monitor and relay physiological data to other devices. Advanced conventional IMDs can be interfaced with implantable sensors directly through wired interconnections, or indirectly via an external intermediary device. Wired interconnections are invasive and require an intrabody tunnel that exposes a patient to adverse side effects, including internal injury, infection, and discomfort. Relay through an external intermediary device requires the periodic upload of stored data, which is only then available to an IMD indirectly by separate download. Thus, the physiological data can go stale before receipt by the IMD.
Alternatively, IMDs can be directly interconnected for data exchange through a wireless intrabody network, such as described in commonly-assigned U.S. Patent Publication No. 2006/0031378, published Feb. 9, 2006, pending, the disclosure of which is incorporated by reference. Multiple IMDs exchange data wirelessly through acoustic or radio frequency (RF) connections. Wireless intrabody interconnection alleviates the need for large onboard storage for holding monitored data, which can instead be immediately exchanged between the multiple IMDs.
Effective wireless intra-IMD communications, though, require maintaining interconnected IMDs in synchrony. Digital components within each device are susceptible to factors affecting performance, such as temperature, age, mechanical and electrical tolerances, and operational environment. Oscillators, for instance, control the timing of IMD operations, but frequency drift, which occurs naturally over time, can skew an oscillator's timing, which in turn skews IMD operation. Similarly, transducers convert electrical signals into and from acoustic energy. Channel characteristics can degrade transducer efficiency. Oscillator frequency drift can further degrade transducer efficiency by skewing transducer operation away from a trim frequency. Conventional IMD synchronization fails to compensate for oscillator-precipitated transducer skew.
U.S. Pat. No. 6,823,031, issued Nov. 23, 2004, to Tatem, Jr., discloses automated frequency compensation for remote synchronization. An oscillator is stepped through offset frequencies that are associated with a lock range of a phase lock loop (PLL). Oscillator frequencies are incremented until a desired result is achieved, after which control reverts back to the PLL. However, the oscillator for a device is trimmed without transducer adjustment.
U.S. Pat. No. 7,187,979, issued Mar. 6, 2007, to Haubrich et al., discloses medical device synchronization with reduced reliance on periodic polling. The internal clocks of two devices, such as an IMD and an external device, can be synchronized by computing time drift as a function of measured skew. In a further embodiment, an IMD is synchronized to a time signal generated by an external time reference with polling performed only when a device is likely to be receptive. However, oscillator synchronization is reliant on an external reference signal and is trimmed without transducer adjustment.
Therefore, an approach is needed to provide intracorporeal trim of transducers of wirelessly interconnected IMDs. Preferably, such an approach would avoid significant depletion of resources.
The transducers in a pair of IMDs are trimmed through an intracorporeal frequency sweep of their respective oscillators. A search space of oscillator trim frequencies for each IMD is determined. An initiating IMD notifies a responding IMD to begin a sweep of the oscillator trim frequencies. Each IMD selects oscillator trim frequencies through a heuristic mapping of the search space. For each pair of selected oscillator trim frequencies, the initiating IMD repeatedly sends a command and monitors responses received from the responding IMD. The oscillator trim frequency pairing providing the strongest command exchange is selected to trim the transducers. Safe operation is assured by saving the responding IMD's new oscillator trim frequency into volatile memory to permit recovery of the original, albeit possibly non-optimal, oscillator trim frequency if subsequent communication with the initiating IMD fails.
One embodiment provides a system and method for in situ trimming of oscillators in a pair of IMDs. Each frequency over a range of oscillator trim frequencies for an initiating IMD is selected and a plurality of commands are sent via an acoustic transducer in situ over the frequency selected. Each frequency over a range of oscillator trim frequencies for a responding IMD is selected and a response to each of the commands received is sent via an acoustic transducer in situ over the frequency selected. The responses received by the initiating IMD are evaluated and a combination of the oscillator trim frequencies for both IMDs that together exhibit a strongest acoustic wave is identified. Oscillators in both IMDs are trimmed to the oscillator trim frequencies in the combination identified.
A further embodiment provides a system and method for intracorporeal trimming of acoustic transducers for a plurality of interconnected IMDs. A two-dimensional search space is mapped and includes a range of oscillator trim frequencies for an initiating and a responding IMD. On the initiating IMD, a sweep of the oscillator trim frequency ranges is performed that includes selecting each oscillator trim frequency in the search space, and sending a series of commands to the responding IMD at the selected oscillator trim frequency via an acoustic transducer. On the responding IMD, a sweep of the oscillator trim frequency ranges is also performed that includes selecting each oscillator trim frequency in the search space, and sending a response to each command that is received to the initiating IMD at the selected oscillator trim frequency via an acoustic transducer. The responses received by the initiating IMD from the responding IMD evaluated and the oscillator trim frequencies indicating a strongest acoustic wave are selected. The oscillators on both IMDs are set to the selected oscillator trim frequencies.
Still other embodiments will become readily apparent to those skilled in the art from the following detailed description, wherein are described embodiments of the invention by way of illustrating the best mode contemplated for carrying out the invention. As will be realized, the invention is capable of other and different embodiments and its several details are capable of modifications in various obvious respects, all without departing from the spirit and the scope of the present invention. Accordingly, the drawings and detailed description are to be regarded as illustrative in nature and not as restrictive.
Although described in relation to medical devices intended for providing cardio and cardiopulmonary diagnosis, therapy, or monitoring, the embodiments described apply generally to all implantable medical devices and sensors capable of wireless intracorporeal interconnection and remotely interrogated or programmed.
Recent advances in microelectronics have made direct IMD-to-IMD, including IMD-with-implantable sensor, intercommunications via wireless acoustic telemetry commercially practicable.
By way of example, a therapeutic IMD 12, such as a cardiac therapy device, is paired with a monitoring IMD 14, such as a cardiac monitoring device. Cardiac therapy devices include pacemakers, implantable cardioverter-defibrillators, biventricular pacemakers, and similar devices. The therapeutic IMD 12 is surgically implanted in the chest, abdomen, or other internal bodily location of a patient 10 and includes physically attached components, such as leads 13 for providing monitoring within and for delivering therapy to the patient's heart 11. The monitoring IMD 14 is deployed intravascularly through a catheter into the left coronary artery or other internal bodily location, or implanted in similar fashion as the therapeutic IMD 12. The monitoring IMD 14 is self-contained and may not be intended for surgical access or removal. Other forms of IMD and components are possible.
Each IMD 12, 14 encloses operational circuitry within a hermetically-sealed housing. Referring to the therapeutic IMD 12, the operational circuitry generally includes a transducer 15; oscillator 16; control circuitry 17; memory 18; and power source 19, which provides a finite power supply for the operational circuitry. The monitoring IMD 14 also includes operational circuitry such as a transducer 15 a and oscillator 16 a, as further shown, for example, in
In a further embodiment, the patient data can be evaluated, either by an IMD 12, 14, or an external device, for the occurrence of one or more chronic or acute health conditions, such as described in related, commonly-owned U.S. Pat. No. 6,336,903, to Bardy, issued Jan. 8, 2002; U.S. Pat. No. 6,368,284, to Bardy, issued Apr. 9, 2002; U.S. Pat. No. 6,398,728, to Bardy, issued Jun. 4, 2002; U.S. Pat. No. 6,411,840, to Bardy, issued Jun. 25, 2002; and U.S. Pat. No. 6,440,066, to Bardy, issued Aug. 27, 2002, the disclosures of which are incorporated by reference.
In a still further embodiment, the patient data is extracorporeally safeguarded against unauthorized disclosure to third parties, including during collection, assembly, evaluation, transmission, and storage, to protect patient privacy and comply with recently enacted medical information privacy laws, such as the Health Insurance Portability and Accountability Act (HIPAA) and the European Privacy Directive. At a minimum, patient health information that identifies a particular individual with health- and medical-related information is treated as protectable, although other types of sensitive information in addition to or in lieu of specific patient health information could also be protectable.
Oscillator and Transducer Frequency Trim
In general, an oscillator regulates the timing of operations performed by digital components within an IMD, which has a direct affect on the operation of a transducer.
As required, to restore transducer efficiency and synchrony, the oscillator 16 must be trimmed.
The transducer 15 has a response based on the frequency of the exciting signal.
Over time, the transducer's output response curve can change.
The transducers for a pair of IMDs can be safely and efficiently trimmed by performing a sweep through their respective oscillator trim frequency ranges. The trim frequency ranges can be mapped heuristically.
Referring first to
Upon completion of the sweep, the initiating IMD evaluates the responses received from the responding IMD during each iteration and selects a new combination of oscillator trim frequencies for both of the IMDs (step 68). The new oscillator trim frequencies are selected based on the strongest acoustic wave observed, which could be indirectly indicated by the number of responses that the initiating IMD successfully received back from the responding IMD by directly reading the signal-to-noise ratio, or by making other quantitative measurement of signal strength. For instance, a suboptimal oscillator trim frequency pairing might result in only a few of the commands being successfully received by the responding IMD, or in a low signal-to-noise ratio. The responding IMD would respond to the received commands, yet the suboptimal frequency pairing might also result in even fewer responses being successfully received by the initiating IMD. A frequency pairing exhibiting higher rates of command and response receipts would indicate a stronger acoustic wave, or a high signal-to-noise ratio. Other oscillator trim frequency selection criteria are possible. The new oscillator trim frequency is sent to the responding IMD (step 69). Similarly, the new oscillator trim frequency for the initiating IMD is set and saved (step 70), after which transducer trimming is complete.
Referring next to
Upon completion of the sweep, the responding IMD waits to receive a new oscillator trim frequency from the initiating IMD (step 88). Upon receipt, the new oscillator trim frequency for the responding IMD is set and saved into volatile memory (step 89), after which transducer trimming is complete.
As the new oscillator trim frequency is stored in volatile memory, the new frequency is only temporarily retained. A reference oscillator trim frequency for the oscillator 16 is permanently maintained in the non-volatile memory. Thus, should the new oscillator trim frequency prove too aggressive or ineffective, thereby resulting in loss of communications or device error, the reference oscillator trim frequency can be automatically recovered from the non-volatile memory. The volatile memory is cleared, generally by performing a device reset or by allowing the responding IMD to enter a standby or sleep mode, which causes the new oscillator trim frequency to be erased. Following erasure of the volatile memory, the responding IMD reverts back to the reference oscillator trim frequency maintained in the non-volatile memory and resumes normal operation.
In a further embodiment, the new oscillator trim frequency can later be stored into non-volatile memory upon receiving a command to permanently store the frequency. The initiating IMD will generally issue the command to the responding IMD only after first confirming that the new oscillator trim frequency is reliable and safe and can be used without adverse effect to device operation.
Oscillator Trim Frequency Search Space Mappings
Both initiating and responding IMDs perform a sweep of possible oscillator trim frequencies to determine the best frequency pairing. The complete search space can be expressed as an n×m matrix, where there are n possible initiating IMD oscillator frequencies and there are m possible responding IMD oscillator frequencies.
Each sweep through the oscillator trim frequency search spaces simultaneously exercises the oscillators and transducers of both IMDs to enable identification of a locally optimal pairing of oscillator trim frequencies. Referring first to
An exhaustive sweep 106 tests the entire search space, but at the expense of onboard resource depletion and time. The sweep can be made more efficient by testing only a representative subset of the search space. Referring next to
Various selection criteria may apply in deciding the representative subset of the search space. For example, a search path can be mapped from an initial reference oscillator frequency pairing 115 by mapping a spiral search pattern through the search space. A spiral search pattern can be expressed in polar coordinates by selecting those oscillator frequency pairings located at a radius r specified as a continuous monotonic function of an angle θ, which is initially measured from the reference oscillator frequency pairing 115. Those oscillator frequency pairings falling within a fixed distance of the search path are selected and evaluated, thereby requiring fewer pairings to exercise the oscillators and transducers of the initiating and responding IMDs. Other search path shapes and patterns are possible.
The selective sweep 116 tests a representative part or subset of the search space, yet does not take into consideration whether the search path is producing hopeful or unpromising results. The sweep can be further improved by progressively evaluating interim oscillator trim frequency pairings. Referring to
In a further embodiment, the oscillators of the initiating and responding IMDs can be synchronized. During trimming of the transducers, oscillator frequencies may be increased or decreased based on transducer response. Actual oscillator frequencies are not measured and may be unknown due to drift.
A short command sequence can be used to synchronize the oscillators.
While the invention has been particularly shown and described as referenced to the embodiments thereof, those skilled in the art will understand that the foregoing and other changes in form and detail may be made therein without departing from the spirit and scope of the invention.
|Patente citada||Fecha de presentación||Fecha de publicación||Solicitante||Título|
|US3672352||9 Abr 1969||27 Jun 1972||George D Summers||Implantable bio-data monitoring method and apparatus|
|US4361153||27 May 1980||30 Nov 1982||Cordis Corporation||Implant telemetry system|
|US4373527||27 Abr 1979||15 Feb 1983||The Johns Hopkins University||Implantable, programmable medication infusion system|
|US4481950||3 Abr 1981||13 Nov 1984||Medtronic, Inc.||Acoustic signalling apparatus for implantable devices|
|US4519401||20 Sep 1983||28 May 1985||Case Western Reserve University||Pressure telemetry implant|
|US4573994||7 Dic 1981||4 Mar 1986||The Johns Hopkins University||Refillable medication infusion apparatus|
|US4614192||23 Mar 1983||30 Sep 1986||Mieczyslaw Mirowski||Implantable cardiac defibrillator employing bipolar sensing and telemetry means|
|US4616640||14 Nov 1983||14 Oct 1986||Steven Kaali||Birth control method and device employing electric forces|
|US4651740||19 Feb 1985||24 Mar 1987||Cordis Corporation||Implant and control apparatus and method employing at least one tuning fork|
|US4793825||11 Sep 1985||27 Dic 1988||The Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom And Northern Ireland||Active silicon implant devices|
|US5113859||25 Jun 1990||19 May 1992||Medtronic, Inc.||Acoustic body bus medical device communication system|
|US5423334||1 Feb 1993||13 Jun 1995||C. R. Bard, Inc.||Implantable medical device characterization system|
|US5778882||24 Feb 1995||14 Jul 1998||Brigham And Women's Hospital||Health monitoring system|
|US5800478||7 Mar 1996||1 Sep 1998||Light Sciences Limited Partnership||Flexible microcircuits for internal light therapy|
|US5814089||18 Dic 1996||29 Sep 1998||Medtronic, Inc.||Leadless multisite implantable stimulus and diagnostic system|
|US5833603||13 Mar 1996||10 Nov 1998||Lipomatrix, Inc.||Implantable biosensing transponder|
|US6140740||30 Dic 1997||31 Oct 2000||Remon Medical Technologies, Ltd.||Piezoelectric transducer|
|US6141588||24 Jul 1998||31 Oct 2000||Intermedics Inc.||Cardiac simulation system having multiple stimulators for anti-arrhythmia therapy|
|US6162238||24 Feb 1999||19 Dic 2000||Aaron V. Kaplan||Apparatus and methods for control of body lumens|
|US6164284||25 Mar 1998||26 Dic 2000||Schulman; Joseph H.||System of implantable devices for monitoring and/or affecting body parameters|
|US6170488||24 Mar 1999||9 Ene 2001||The B. F. Goodrich Company||Acoustic-based remotely interrogated diagnostic implant device and system|
|US6185452||25 Feb 1998||6 Feb 2001||Joseph H. Schulman||Battery-powered patient implantable device|
|US6200265||16 Abr 1999||13 Mar 2001||Medtronic, Inc.||Peripheral memory patch and access method for use with an implantable medical device|
|US6234973||18 Nov 1999||22 May 2001||Medtronic, Inc.||Implantable medical device for sensing absolute blood pressure and barometric pressure|
|US6236889||22 Ene 1999||22 May 2001||Medtronic, Inc.||Method and apparatus for accoustically coupling implantable medical device telemetry data to a telephonic connection|
|US6277078||19 Nov 1999||21 Ago 2001||Remon Medical Technologies, Ltd.||System and method for monitoring a parameter associated with the performance of a heart|
|US6308099||13 Nov 1998||23 Oct 2001||Intermedics Inc.||Implantable device and programmer system which permits multiple programmers|
|US6336903||16 Nov 1999||8 Ene 2002||Cardiac Intelligence Corp.||Automated collection and analysis patient care system and method for diagnosing and monitoring congestive heart failure and outcomes thereof|
|US6368284||16 Nov 1999||9 Abr 2002||Cardiac Intelligence Corporation||Automated collection and analysis patient care system and method for diagnosing and monitoring myocardial ischemia and outcomes thereof|
|US6398728||16 Nov 1999||4 Jun 2002||Cardiac Intelligence Corporation||Automated collection and analysis patient care system and method for diagnosing and monitoring respiratory insufficiency and outcomes thereof|
|US6411840||16 Nov 1999||25 Jun 2002||Cardiac Intelligence Corporation||Automated collection and analysis patient care system and method for diagnosing and monitoring the outcomes of atrial fibrillation|
|US6431175||6 May 1999||13 Ago 2002||Remon Medical Technologies Ltd.||System and method for directing and monitoring radiation|
|US6440066||16 Nov 1999||27 Ago 2002||Cardiac Intelligence Corporation||Automated collection and analysis patient care system and method for ordering and prioritizing multiple health disorders to identify an index disorder|
|US6442413||15 May 2000||27 Ago 2002||James H. Silver||Implantable sensor|
|US6442433||26 Oct 1999||27 Ago 2002||Medtronic, Inc.||Apparatus and method for remote troubleshooting, maintenance and upgrade of implantable device systems|
|US6445953||16 Ene 2001||3 Sep 2002||Kenergy, Inc.||Wireless cardiac pacing system with vascular electrode-stents|
|US6453196 *||7 Ago 2000||17 Sep 2002||Cardiac Pacemakers, Inc.||High frequency oscillator for implantable medical devices|
|US6456602 *||7 Abr 1999||24 Sep 2002||Legerity||Method and apparatus for achieving frequency diversity by use of multiple images|
|US6456883||26 Abr 2000||24 Sep 2002||Medtronic, Inc.||Apparatus and method for allowing immediate retrieval for information and identification from an implantable medical device having a depleted power source|
|US6472991||15 Jun 2001||29 Oct 2002||Alfred E. Mann Foundation For Scientific Research||Multichannel communication protocol configured to extend the battery life of an implantable device|
|US6571128 *||22 Ene 2001||27 May 2003||Medtronic Minimed, Inc.||Microprocessor controlled ambulatory medical apparatus with hand held communication device|
|US6628989||16 Oct 2000||30 Sep 2003||Remon Medical Technologies, Ltd.||Acoustic switch and apparatus and methods for using acoustic switches within a body|
|US6638231||18 Dic 2000||28 Oct 2003||Biosense, Inc.||Implantable telemetric medical sensor and method|
|US6654638||6 Abr 2000||25 Nov 2003||Cardiac Pacemakers, Inc.||Ultrasonically activated electrodes|
|US6675049||17 Jul 2001||6 Ene 2004||Medtronic, Inc.||Method and apparatus for automatic implantable medical lead recognition and configuration|
|US6712772||15 Feb 2002||30 Mar 2004||Biocontrol Medical Ltd.||Low power consumption implantable pressure sensor|
|US6764446||21 Jun 2001||20 Jul 2004||Remon Medical Technologies Ltd||Implantable pressure sensors and methods for making and using them|
|US6783499||8 Jun 2001||31 Ago 2004||Biosense, Inc.||Anchoring mechanism for implantable telemetric medical sensor|
|US6792311||24 Ene 2003||14 Sep 2004||Intermedics Inc.||Implantable device and programmer system which permits multiple programmers|
|US6809507||28 Dic 2001||26 Oct 2004||Medtronic Minimed, Inc.||Implantable sensor electrodes and electronic circuitry|
|US6823031||20 Ene 2000||23 Nov 2004||Wavtrace, Inc.||Automated frequency compensation for remote synchronization|
|US6840956||10 Mar 2000||11 Ene 2005||Remon Medical Technologies Ltd||Systems and methods for deploying a biosensor with a stent graft|
|US6855115||22 Ene 2002||15 Feb 2005||Cardiomems, Inc.||Implantable wireless sensor for pressure measurement within the heart|
|US6895265||25 Jun 2002||17 May 2005||James H. Silver||Implantable sensor|
|US6907285||17 Jul 2002||14 Jun 2005||Kenergy, Inc.||Implantable defibrillartor with wireless vascular stent electrodes|
|US6978182||27 Dic 2002||20 Dic 2005||Cardiac Pacemakers, Inc.||Advanced patient management system including interrogator/transceiver unit|
|US6985773||7 Feb 2002||10 Ene 2006||Cardiac Pacemakers, Inc.||Methods and apparatuses for implantable medical device telemetry power management|
|US7003350||3 Nov 2003||21 Feb 2006||Kenergy, Inc.||Intravenous cardiac pacing system with wireless power supply|
|US7018336||27 Dic 2001||28 Mar 2006||Medtronic Minimed, Inc.||Implantable sensor flush sleeve|
|US7024248||19 Nov 2001||4 Abr 2006||Remon Medical Technologies Ltd||Systems and methods for communicating with implantable devices|
|US7027871||31 Oct 2002||11 Abr 2006||Medtronic, Inc.||Aggregation of data from external data sources within an implantable medical device|
|US7033322||8 Nov 2001||25 Abr 2006||Silver James H||Implantable sensor|
|US7061381||9 Sep 2002||13 Jun 2006||Beezerbug Incorporated||Ultrasonic transmitter and receiver systems and products using the same|
|US7134999||22 Ago 2003||14 Nov 2006||Dexcom, Inc.||Optimized sensor geometry for an implantable glucose sensor|
|US7187979||25 Abr 2003||6 Mar 2007||Medtronic, Inc.||Medical device synchronization|
|US7198603||14 Abr 2003||3 Abr 2007||Remon Medical Technologies, Inc.||Apparatus and methods using acoustic telemetry for intrabody communications|
|US7214189||1 Sep 2005||8 May 2007||Proteus Biomedical, Inc.||Methods and apparatus for tissue activation and monitoring|
|US7236821||19 Feb 2002||26 Jun 2007||Cardiac Pacemakers, Inc.||Chronically-implanted device for sensing and therapy|
|US7273454||24 Oct 2003||25 Sep 2007||Brigham And Women's Hospital||Health monitoring system|
|US7273457||20 May 2002||25 Sep 2007||Remon Medical Technologies, Ltd.||Barometric pressure correction based on remote sources of information|
|US7399313||27 May 2003||15 Jul 2008||Brown Peter S||Endovascular graft with separable sensors|
|US7425200||15 May 2002||16 Sep 2008||Transoma Medical, Inc.||Implantable sensor with wireless communication|
|US7452334||13 Sep 2004||18 Nov 2008||The Regents Of The University Of Michigan||Antenna stent device for wireless, intraluminal monitoring|
|US7481771||7 Jul 2004||27 Ene 2009||Cardiomems, Inc.||Implantable wireless sensor for pressure measurement within the heart|
|US20010043514||15 May 2001||22 Nov 2001||Casio Computer Co., Ltd.||Body wearable information processing terminal device|
|US20020042561||30 Nov 2001||11 Abr 2002||Schulman Joseph H.||Implantable sensor and integrity tests therefor|
|US20020045812||1 Jun 2001||18 Abr 2002||Shlomo Ben-Haim||Implantable sensor for determining position coordinates|
|US20020151770||4 Ene 2002||17 Oct 2002||Noll Austin F.||Implantable medical device with sensor|
|US20020183628||31 May 2002||5 Dic 2002||Sanford Reich||Pressure sensing endograft|
|US20030009204||6 Jul 2001||9 Ene 2003||Amundson Mark D.||Adapative telemetry system and method for an implantable medical device|
|US20030136417||22 Ene 2002||24 Jul 2003||Michael Fonseca||Implantable wireless sensor|
|US20030181794||28 Ene 2003||25 Sep 2003||Rini Christopher J.||Implantable sensor housing, sensor unit and methods for forming and using the same|
|US20030191383||4 Abr 2003||9 Oct 2003||Shlomo Ben-Haim||Implantable sensor for determining position coordinates based on electromagnetic waves|
|US20040057340||10 Abr 2003||25 Mar 2004||Joy Charles-Erickson||Personal, medical & financial risk management device|
|US20040064133||31 Dic 2002||1 Abr 2004||Medtronic-Minimed||Implantable sensor method and system|
|US20040088009||31 Oct 2002||6 May 2004||Degroot Paul J.||Auxilary central nervous system pre-pulse for shock pain inhibition|
|US20040152999||20 Ene 2004||5 Ago 2004||Biocontrol Medical Ltd||Low power consumption implantable pressure sensor|
|US20050056539||25 Oct 2004||17 Mar 2005||Medtronic-Minimed, Inc.||Implantable sensor electrodes and electronic circuitry|
|US20050159789||14 Mar 2005||21 Jul 2005||Transoma Medical, Inc.||Implantable sensor with wireless communication|
|US20050187482||16 Sep 2004||25 Ago 2005||O'brien David||Implantable wireless sensor|
|US20050215887||16 May 2005||29 Sep 2005||Shlomo Ben-Haim||Medical system using implantable sensor in bone for determining position coordinates|
|US20050242479||3 May 2004||3 Nov 2005||Petisce James R||Implantable analyte sensor|
|US20060004263||29 Jun 2004||5 Ene 2006||Norbert Feliss||Hard disk drive medical monitor with sound-proofing|
|US20060009818||9 Jul 2004||12 Ene 2006||Von Arx Jeffrey A||Method and apparatus of acoustic communication for implantable medical device|
|US20060030903||9 Ago 2004||9 Feb 2006||Michael Seeberger||Dynamic telemetry link selection for an implantable device|
|US20060031378||5 Ago 2004||9 Feb 2006||Vineel Vallapureddy||System and method for providing digital data communications over a wireless intra-body network|
|US20060085039||20 Oct 2004||20 Abr 2006||Hastings Roger N||Leadless cardiac stimulation systems|
|US20060085041||7 Mar 2005||20 Abr 2006||Hastings Roger N||Leadless cardiac stimulation systems|
|US20060085042||7 Mar 2005||20 Abr 2006||Hastings Roger N||Leadless cardiac stimulation systems|
|US20060136004||21 Dic 2005||22 Jun 2006||Ebr Systems, Inc.||Leadless tissue stimulation systems and methods|
|US20070142728||28 Feb 2007||21 Jun 2007||Avi Penner||Apparatus and methods using acoustic telemetry for intrabody communications|
|US20070208261 *||2 Mar 2006||6 Sep 2007||Jeremy Maniak||Implantable medical device with embedded programmable non-volatile memory|
|US20080021333||20 Jul 2007||24 Ene 2008||Cardiac Pacemakers, Inc.||Multiple sensor deployment|
|US20080021972||20 Jul 2007||24 Ene 2008||Cardiac Pacemakers, Inc.||System and method for addressing implantable devices|
|US20080082146 *||28 Sep 2007||3 Abr 2008||Cardiac Pacemakers, Inc||Temperature compensation for analog circuits in implantable medical device|
|US20080114224 *||6 Sep 2007||15 May 2008||Innuravation Llc||Methods and systems for acoustic data transmission|
|US20080129457||19 Ene 2006||5 Jun 2008||Swisscom Mobile Ag||Identification Method and System and Device Suitable for Said Method and System|
|US20080288038 *||6 Dic 2006||20 Nov 2008||Saurav Paul||Method for Displaying Catheter Electrode-Tissue Contact in Electro-Anatomic Mapping and Navigation System|
|US20090075687||27 Abr 2006||19 Mar 2009||Sony Computer Entertainment Inc.||Center Device|
|US20090177251||7 Ene 2009||9 Jul 2009||Paul Huelskamp||System And Method For In Situ Trimming Of Oscillators In A Pair Of Implantable Medical Devices|
|US20090198307||22 Ene 2009||6 Ago 2009||Bin Mi||Direct inductive/acoustic converter for implantable medical device|
|US20100042177||18 Feb 2010||Cardiac Pacemakers, Inc.||Performance assessment and adaptation of an acoustic communication link|
|US20100198307||14 Abr 2010||5 Ago 2010||Medtronic, Inc.||Medical device programmer|
|EP0300552A1||12 Jul 1988||25 Ene 1989||Cordis Europa N.V.||An infusion system for infusion of fluids into a living body|
|WO2004089465A1||6 Abr 2004||21 Oct 2004||Remon Medical Technologies Ltd||Acoustic telemetry apparatus for intrabody communications|
|WO2006045073A1||19 Oct 2005||27 Abr 2006||Boston Scient Scimed Inc||Leadless cardiac stimulation systems|
|WO2006045075A1||19 Oct 2005||27 Abr 2006||Boston Scient Scimed Inc||Leadless cardiac stimulation systems|
|WO2007070794A2||12 Dic 2006||21 Jun 2007||Cardiac Pacemakers Inc||System and method for analyzing cardiovascular pressure measurements made within a human body|
|WO2009102640A1||6 Feb 2009||20 Ago 2009||Cardiac Pacemakers Inc||Systems and methods for controlling wireless signal transfers between ultrasound-enabled medical devices|
|Patente citante||Fecha de presentación||Fecha de publicación||Solicitante||Título|
|US8401662||13 Ene 2012||19 Mar 2013||Cardiac Pacemakers, Inc.||Performance assessment and adaptation of an acoustic communication link|
|US8594802||28 Feb 2013||26 Nov 2013||Cardiac Pacemakers, Inc.||Performance assessment and adaptation of an acoustic communication link|
|Clasificación de EE.UU.||607/60, 607/32|
|Clasificación cooperativa||A61N1/37288, A61N1/37217|
|Clasificación europea||A61N1/372D2, A61N1/372D8S|
|9 Ene 2009||AS||Assignment|
Owner name: CARDIAC PACEMAKERS, INC., MINNESOTA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:HUELSKAMP, PAUL;HARRIS, THOMAS J.;TRAN, BINH C.;AND OTHERS;REEL/FRAME:022083/0409;SIGNING DATES FROM 20081218 TO 20090105
Owner name: CARDIAC PACEMAKERS, INC., MINNESOTA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:HUELSKAMP, PAUL;HARRIS, THOMAS J.;TRAN, BINH C.;AND OTHERS;SIGNING DATES FROM 20081218 TO 20090105;REEL/FRAME:022083/0409
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