Patente US8080405 - Semiconductor nanocrystal probes for biological applications and process for ...

Citas

Patente citada	Fecha de presentación	Fecha de emisión	Cesionario original	Título
US3954666	11 Jul 1974	4 May 1976	E. I. Du Pont de Nemours and Company	Semipermeable microcapsules containing heterogeneous catalysts and ferromagnetic materials
US3996345	30 Jun 1975	7 Dic 1976	Syva Company	Fluorescence quenching with immunological pairs in immunoassays
US4238195	18 Ene 1979	9 Dic 1980	Miles Laboratories, Inc.	Fluorescer-labeled specific binding assays
US4250205	12 Sep 1978	10 Feb 1981	Agence Nationale de Valorisation de la Recherche (ANVAR)	Process for depositing a III-V semi-conductor layer on a substrate
US4594264	20 Nov 1984	10 Jun 1986	Hughes Aircraft Company	Method for forming gallium arsenide from thin solid films of gallium-arsenic complexes
US4637988	3 Feb 1986	20 Ene 1987	Eastman Kodak Company	Fluorescent labels for immunoassay
US4738932	3 Dic 1985	19 Abr 1988	Advanced Polymer Systems, Inc.	Reaginic test for syphilis
US4777128	27 May 1986	11 Oct 1988	Ethigen Corporation	Fluorescence immunoassay involving energy transfer between two fluorophores
US4798701	13 Jul 1987	17 Ene 1989	International Business Machines Corporation	Method of synthesizing amorphous group IIIA-group VA compounds
US4802951	23 Dic 1987	7 Feb 1989	Trustees of Boston University University of Colorado Foundation, Inc.	Method for parallel fabrication of nanometer scale multi-device structures
US4814668	23 Dic 1987	21 Mar 1989	Matsushita Electric Industrial Co., Ltd.	Electroluminescent display device
US5084128	23 Oct 1990	28 Ene 1992	E. I. Du Pont de Nemours and Company	Low-temperature synthesis of group III-group V semiconductors
US5101827	11 Mar 1988	7 Abr 1992	Immunomedics, Inc.	Lymphographic and organ imaging method and kit
US5147841	23 Nov 1990	15 Sep 1992	The United States of America as represented by the United States Department of Energy	Method for the preparation of metal colloids in inverse micelles and product preferred by the method
US5200668	18 Jul 1990	6 Abr 1993	Mitsui Toatsu Chemicals, Inc.	Luminescence element
US5212426	24 Ene 1991	18 May 1993	Motorola, Inc.	Integrally controlled field emission flat display device
US5219577	22 Jun 1990	15 Jun 1993	The Regents of the University of California	Biologically active composition having a nanocrystalline core
US5260957	29 Oct 1992	9 Nov 1993	The Charles Stark Draper Laboratory, Inc.	Quantum dot Laser
US5262357	22 Nov 1991	16 Nov 1993	The Regents of the University of California	Low temperature thin films formed from nanocrystal precursors
US5293050	25 Mar 1993	8 Mar 1994	International Business Machines Corporation	Semiconductor quantum dot light emitting/detecting devices
US5304786	5 Ene 1990	19 Abr 1994	Symbol Technologies, Inc.	High density two-dimensional bar code symbol
US5308804	15 Dic 1992	3 May 1994		Moving disks made of semiconductor nanocrystallite embedded glass
US5319209	19 Nov 1992	7 Jun 1994	Hammamatsu Photonics K.K.	Method for measurement of intracellular ion concentration using fluorescence probe dyes
US5354707	9 Nov 1993	11 Oct 1994	International Business Machines Corporation	Method of making semiconductor quantum dot light emitting/detecting devices
US5395791	20 Oct 1993	7 Mar 1995	Minnesota Mining and Manufacturing Company	Growth of II VI laser diodes with quantum wells by atomic layer epitaxy and migration enhanced epitaxy
US5422489	24 Ene 1994	6 Jun 1995		Light emitting device
US5427767	13 May 1992	27 Jun 1995	Institut fur Diagnostikforschung GmbH an der Freien Universitat Berlin	Nanocrystalline magnetic iron oxide particles-method for preparation and use in medical diagnostics and therapy
US5429824	15 Dic 1992	4 Jul 1995	Eastman Kodak Company	Use of tyloxapole as a nanoparticle stabilizer and dispersant
US5434878	18 Mar 1994	18 Jul 1995	Brown University Research Foundation	Optical gain medium having doped nanocrystals of semiconductors and also optical scatterers
US5442254	4 May 1993	15 Ago 1995	Motorola, Inc.	Fluorescent device with quantum contained particle screen
US5448582	18 Mar 1994	5 Sep 1995	Brown University Research Foundation	Optical sources having a strongly scattering gain medium providing laser-like action
US5455489	11 Abr 1994	3 Oct 1995		Displays comprising doped nanocrystal phosphors
US5460831	4 Nov 1993	24 Oct 1995	The Regents of the University of California	Targeted transfection nanoparticles
US5474591	31 Ene 1994	12 Dic 1995	Duke University	Method of synthesizing III-V semiconductor nanocrystals
US5492080	21 Dic 1994	20 Feb 1996	Matsushita Electric Industrial Co., Ltd.	Crystal-growth method and semiconductor device production method using the crystal-growth method
US5496536	25 Abr 1995	5 Mar 1996		Percutaneous lymphography
US5499260	29 Jul 1994	12 Mar 1996	Matsushita Electric Industrial Co., Ltd.	Semiconductor laser and a method for fabricating the same
US5505928	21 Abr 1994	9 Abr 1996	The Regents of University of California	Preparation of III-V semiconductor nanocrystals
US5515393	4 Ago 1993	7 May 1996	Sony Corporation	Semiconductor laser with ZnMgSSe cladding layers
US5525377	7 Jun 1995	11 Jun 1996	U.S. Philips Corporation	Method of manufacturing encapsulated doped particles
US5537000	29 Abr 1994	16 Jul 1996	The Regents, University of California	Electroluminescent devices formed using semiconductor nanocrystals as an electron transport media and method of making such electroluminescent devices
US5541948	28 Nov 1994	30 Jul 1996	The Regents of the University of California	Transition-metal doped sulfide, selenide, and telluride laser crystal and lasers
US5565324	13 Abr 1994	15 Oct 1996	The Trustees of Columbia University in the City of New York Cold Spring Harbor Laboratory	Complex combinatorial chemical libraries encoded with tags
US5585640	11 Ene 1995	17 Dic 1996		Glass matrix doped with activated luminescent nanocrystalline particles
US5613140	11 Oct 1994	18 Mar 1997	Sony Corporation	Quantum dot-tunnel device which can be selectively excited by a first light emitting source and the information thus stored can be read with a second light emitting source
US5625456	9 Mar 1995	29 Abr 1997	Brown University Research Foundation	Optical sources having a strongly scattering gain medium providing laser-like action
US5674698	30 Mar 1995	7 Oct 1997	SRI International	Up-converting reporters for biological and other assays using laser excitation techniques
US5677545	12 Sep 1994	14 Oct 1997	Motorola	Organic light emitting diodes with molecular alignment and method of fabrication
US5711803	29 Sep 1995	27 Ene 1998	Midwest Research Institute	Preparation of a semiconductor thin film
US5721099	7 Jun 1995	24 Feb 1998	Trustees of Columbia University in the City of New York Cold Spring Harbor Laboratory	Complex combinatorial chemical libraries encoded with tags
US5736330	11 Oct 1995	7 Abr 1998	Luminex Corporation	Method and compositions for flow cytometric determination of DNA sequences
US5747180	5 Dic 1996	5 May 1998	University of Notre Dame Du Lac	Electrochemical synthesis of quasi-periodic quantum dot and nanostructure arrays
US5751018	29 Abr 1994	12 May 1998	The Regents of the University of CAlifornia	Semiconductor nanocrystals covalently bound to solid inorganic surfaces using self-assembled monolayers
US5770299	5 Nov 1996	23 Jun 1998	Mercedes-Benz AG	Marking for objects painted with an effect paint and process for producing the marking
US5786139	9 Dic 1994	28 Jul 1998	PanVera Corporation	Method and kit for detecting nucleic acid cleavage utilizing a covalently attached fluorescent tag
US5789162	7 Jun 1995	4 Ago 1998	Affymax Technologies N.V.	Methods of synthesizing diverse collections of oligomers
US5846517	30 Ene 1997	8 Dic 1998	ImaRx Pharmaceutical Corp.	Methods for diagnostic imaging using a renal contrast agent and a vasodilator
US5856814	1 Ago 1996	5 Ene 1999		Driving method for display apparatus
US5882779	6 Feb 1997	16 Mar 1999	Spectra Science Corporation	Semiconductor nanocrystal display materials and display apparatus employing same
US5906670	18 Jun 1996	25 May 1999	Isis Innovation Limited	Making particles of uniform size
US5910554	6 Jun 1997	8 Jun 1999	Regents Of The University Of Minnesota	Highly cross-linked polymeric supports
US5922537	8 Nov 1996	13 Jul 1999	N.o slashed.AB Immunoassay, Inc.	Nanoparticles biosensor
US5932309	28 Sep 1995	3 Ago 1999	AlliedSignal Inc.	Colored articles and compositions and methods for their fabrication
US5939021	23 Ene 1997	17 Ago 1999		Homogeneous binding assay
US5952665	28 Nov 1997	14 Sep 1999	Nanocrystals Technology L.P.	Composite nanophosphor screen for detecting radiation
US5985173	18 Nov 1997	16 Nov 1999		Phosphors having a semiconductor host surrounded by a shell
US5985353	30 Jul 1997	16 Nov 1999	University of Massachusetts Lowell	Biomolecular synthesis of quantum dot composites
US5990479	25 Nov 1997	23 Nov 1999	Regents of the University of California	Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6005707	21 Nov 1997	21 Dic 1999	Lucent Technologies Inc.	Optical devices comprising polymer-dispersed crystalline materials
US6023540	14 Mar 1997	8 Feb 2000	Trustees of Tufts College	Fiber optic sensor with encoded microspheres
US6054495	29 Sep 1998	25 Abr 2000	The United States of America as represented by the Secretary of the Navy	Synthesis of unagglomerated metal nano-particles at membrane interfaces
US6103868	18 Jun 1998	15 Ago 2000	The Regents of the University of California	Organically-functionalized monodisperse nanocrystals of metals
US6106609	8 Abr 1997	22 Ago 2000	The United States of America as represented by the Secretary of the Navy	Formation of nanocrystalline semiconductor particles within a bicontinuous cubic phase
US6114038	11 Ago 1999	5 Sep 2000	BioCrystal Ltd.	Functionalized nanocrystals and their use in detection systems
US6139585	11 Mar 1998	31 Oct 2000	Depuy Orthopaedics, Inc.	Bioactive ceramic coating and method
US6157047	28 Ago 1998	5 Dic 2000	Kabushiki Kaisha Toshiba	Light emitting semiconductor device using nanocrystals
US6159445	4 Dic 1997	12 Dic 2000	Nycomed Imaging AS	Light imaging contrast agents
US6159742	4 Jun 1999	12 Dic 2000	President and Fellows of Harvard College	Nanometer-scale microscopy probes
US6165440	9 Jul 1998	26 Dic 2000	Board of Regents, The University of Texas System	Radiation and nanoparticles for enhancement of drug delivery in solid tumors
US6167297	5 May 1999	26 Dic 2000		Detecting, localizing, and targeting internal sites in vivo using optical contrast agents
US6179912	20 Dic 1999	30 Ene 2001	BioCrystal Ltd.	Continuous flow process for production of semiconductor nanocrystals
US6207229	5 Ago 1999	27 Mar 2001	Massachusetts Institute of Technology	Highly luminescent color-selective materials and method of making thereof
US6207392	1 Mar 1999	27 Mar 2001	The Regents of the University of California	Semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6224739	25 Ene 1999	1 May 2001	Studiengesellschaft Kohle mbH	Process for preparing solvent-stabilized metal colloids and substrate-immobilized metal clusters
US6225198	4 Feb 2000	1 May 2001	The Regents of the University of California	Process for forming shaped group II-VI semiconductor nanocrystals, and product formed using process
US6251303	18 Sep 1998	26 Jun 2001	Massachusetts Institute of Technology	Water-soluble fluorescent nanocrystals
US6252254	30 Nov 1998	26 Jun 2001	General Electric Company	Light emitting device with phosphor composition
US6262129	31 Jul 1998	17 Jul 2001	International Business Machines Corporation	Method for producing nanoparticles of transition metals
US6274323	5 May 2000	14 Ago 2001	Quantum Dot Corporation	Method of detecting an analyte in a sample using semiconductor nanocrystals as a detectable label
US6294401	17 Jun 1999	25 Sep 2001	Massachusetts Institute of Technology	Nanoparticle-based electrical, chemical, and mechanical structures and methods of making same
US6306610	17 Sep 1999	23 Oct 2001	Massachusetts Institute of Technology	Biological applications of quantum dots
US6306736	4 Feb 2000	23 Oct 2001	The Regents of the University of California	Process for forming shaped group III-V semiconductor nanocrystals, and product formed using process
US6309701	24 May 2000	30 Oct 2001	Bio-Pixels Ltd.	Fluorescent nanocrystal-labeled microspheres for fluorescence analyses
US6312906	14 Ene 2000	6 Nov 2001	Imperial College Innovations, Ltd. Gene Logic, Inc.	Immobilized nucleic acid hybridization reagent and method
US6319426	17 Sep 1999	20 Nov 2001	Massachusetts Institute of Technology	Water-soluble fluorescent semiconductor nanocrystals
US6322901	13 Nov 1997	27 Nov 2001	Massachusetts Institute of Technology	Highly luminescent color-selective nano-crystalline materials
US6326144	24 Sep 1998	4 Dic 2001	Massachusetts Institute of Technology	Biological applications of quantum dots
US6337117	30 Jun 1999	8 Ene 2002	Mitsubishi Chemical Corporation	Optical memory device
US6355432	2 Jun 2000	12 Mar 2002	Affymetrix lnc.	Products for detecting nucleic acids
US6361944	25 Jun 1999	26 Mar 2002	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US6379635	9 Sep 1998	30 Abr 2002	Imperial College of Science, Technology & Medicine	Process for preparing a nanocrystalline material
US6410255	5 May 1999	25 Jun 2002	Aurora Biosciences Corporation	Optical probes and assays
US6417340	20 Oct 2000	9 Jul 2002	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US6423551	8 Jul 1999	23 Jul 2002	The Regents of the University of California	Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6426513	18 Sep 1998	30 Jul 2002	Massachusetts Institute of Technology	Water-soluble thiol-capped nanocrystals
US6444143	29 May 2001	3 Sep 2002	Massachusetts Institute of Technology	Water-soluble fluorescent nanocrystals
US6444192	5 Feb 1999	3 Sep 2002	The Regents of the University of California	Diagnostic imaging of lymph structures
US6447698	17 Sep 1999	10 Sep 2002	Sony Corporation	Method for producing light-emitting substance
US6500622	22 Mar 2001	31 Dic 2002	Quantum Dot Corporation	Methods of using semiconductor nanocrystals in bead-based nucleic acid assays
US6501091	7 Oct 1998	31 Dic 2002	Massachusetts Institute of Technology Hewlett-Packard Company	Quantum dot white and colored light emitting diodes
US6506564	26 Jun 2000	14 Ene 2003	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US6530944	8 Feb 2001	11 Mar 2003	Rice University	Optically-active nanoparticles for use in therapeutic and diagnostic methods
US6548168	8 Ago 2000	15 Abr 2003	The University of Melbourne	Stabilized particles and methods of preparation and use thereof
US6548171	8 Ago 2000	15 Abr 2003		Fluorescent nanocrystal-embedded microspheres for fluorescence analyses
US6576291	8 Dic 2000	10 Jun 2003	Massachusetts Institute of Technology	Preparation of nanocrystallites
US6582921	20 Sep 2001	24 Jun 2003	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses thereof
US6602671	17 Sep 1999	5 Ago 2003	Massachusetts Institute of Technology	Semiconductor nanocrystals for inventory control
US6607829	26 Jul 2000	19 Ago 2003	Massachusetts Institute of Technology	Tellurium-containing nanocrystalline materials
US6610491	28 Sep 2001	26 Ago 2003	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US6617583	24 Sep 1998	9 Sep 2003	Massachusetts Institute of Technology	Inventory control
US6633370	7 Mar 2001	14 Oct 2003	Spectra Science Corporation	Quantum dots, semiconductor nanocrystals and semiconductor particles used as fluorescent coding elements
US6636755	26 Sep 2001	21 Oct 2003	Fuji Photo Film Co., Ltd.	Method and apparatus for obtaining an optical tomographic image of a sentinel lymph node
US6645721	20 Sep 2001	11 Nov 2003	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US6673548	28 Sep 2001	6 Ene 2004	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US6677122	11 Oct 2001	13 Ene 2004	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US6682895	12 Oct 2001	27 Ene 2004	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US6696299	11 May 1999	24 Feb 2004	Massachusetts Institute of Technology	Polarization label for measuring 3-dimensional orientation
US6699723	24 May 2001	2 Mar 2004	The Regents of the University of California	Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6709825	10 Oct 2001	23 Mar 2004	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US6720411	10 Oct 2001	13 Abr 2004	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US6727065	12 Feb 2001	27 Abr 2004	The Regents of the University of California	Methods of use of semiconductor nanocrystal probes for treating a material
US6730269	12 Oct 2001	4 May 2004	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US6750016	28 Mar 2001	15 Jun 2004	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US6759199	20 Sep 2001	6 Jul 2004	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US6767702	12 Ene 2001	27 Jul 2004	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US6773884	7 Ago 2001	10 Ago 2004	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US6774361	30 May 2002	10 Ago 2004	Massachusetts Institute of Technology	Inventory control
US6777186	15 Oct 2001	17 Ago 2004	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US6797412	11 Abr 2000	28 Sep 2004	University of Connecticut	Full color display structures using pseudomorphic cladded quantum dot nanophosphor thin films
US6803719	9 Jul 1999	12 Oct 2004	Massachusetts Institute of Technology	Quantum dot white and colored light-emitting devices
US6804549	25 Abr 2001	12 Oct 2004	Fuji Photo Film Co., Ltd.	Sentinel lymph node detection method and system therefor
US6812334	12 Oct 2001	2 Nov 2004	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US6815064	17 Jul 2002	9 Nov 2004	Quantum Dot Corporation	Luminescent nanoparticles and methods for their preparation
US6818753	12 Oct 2001	16 Nov 2004	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US6819692	14 Mar 2001	16 Nov 2004	Massachusetts Institute of Technology Regents of the University of California	Optical amplifiers and lasers
US6821337	6 Jun 2003	23 Nov 2004	Massachusetts Institute of Technology	Preparation of nanocrystallites
US6828432	11 Oct 2001	7 Dic 2004	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US6846565	28 Mar 2002	25 Ene 2005	Board of Regents, The University of Texas System	Light-emitting nanoparticles and method of making same
US6855551	12 Abr 2001	15 Feb 2005	Massachusetts Institute of Technology	Biological applications of quantum dots
US6858158	24 Ene 2003	22 Feb 2005	Konarka Technologies, Inc.	Low temperature interconnection of nanoparticles
US6861155	19 Ago 2003	1 Mar 2005	Massachusetts Institute of Technology	Highly luminescent color selective nanocrystalline materials
US6861221	11 Oct 2001	1 Mar 2005	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US6864626	2 Jun 1999	8 Mar 2005	The Regents of the University of California	Electronic displays using optically pumped luminescent semiconductor nanocrystals
US6872249	4 Oct 2001	29 Mar 2005	The Board of Trustees of the University of Arkansas	Synthesis of colloidal nanocrystals
US6878814	10 Oct 2001	12 Abr 2005	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US6890777	26 Dic 2002	10 May 2005	Massachusetts Institute of Technology Hewlett-Packard Company	Quantum dot white and colored light emitting diodes
US6902895	12 Oct 2001	7 Jun 2005	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US6903207	12 Oct 2001	7 Jun 2005	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US6914265	26 Dic 2002	5 Jul 2005	Massachusetts Institute of Technology Lumileds Lighting U.S., LLC	Quantum dot white and colored light emitting diodes
US6921496	20 Mar 2001	26 Jul 2005	Massachusetts Institute of Technology The United States of Americas as represented by the Secretary of the Navy	Inorganic particle conjugates
US6927069	24 May 2002	9 Ago 2005	The Regents of the University of California	Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6947979	16 Ago 2000	20 Sep 2005	Entrust, Inc.	Controlling use of a network resource
US6962786	9 Abr 2003	8 Nov 2005	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US6969761	12 Oct 2001	29 Nov 2005	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US6984491	7 Dic 2001	10 Ene 2006	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US6986989	12 Oct 2001	17 Ene 2006	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US7049148	19 Dic 2003	23 May 2006	Massachusetts Institute of Technology	Method for measuring 3-dimensional orientation of a photoactive moiety
US7060243	9 Jun 2003	13 Jun 2006	Massachusetts Institute of Technology	Tellurium-containing nanocrystalline materials
US7098320	11 Oct 2001	29 Ago 2006	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US7101718	12 Ago 2004	5 Sep 2006	The Regents of the University of California	Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US7125605	12 Oct 2004	24 Oct 2006	Massachusetts Institute of Technology	Highly luminescent color-selective nanocrystalline materials
US7138098	8 Oct 2004	21 Nov 2006	Massachusetts Institute of Technology	Preparation of nanocrystallites
US7160613	15 Ago 2003	9 Ene 2007	Massachusetts Institute of Technology	Stabilized semiconductor nanocrystals
US7169556	8 Oct 2002	30 Ene 2007	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US7181266	6 Feb 2004	20 Feb 2007	Massachusetts Institute of Technology Beth Isreal Deaconess Medical Center, Inc.	Materials and methods for near-infrared and infrared lymph node mapping
US7189417	1 May 2003	13 Mar 2007	The Trustees of the University of Pennsylvania	Nanometer-sized carrier medium
US7208587	13 Ago 2003	24 Abr 2007	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US7235361	3 Nov 2004	26 Jun 2007	Massachusetts Institute of Technology	Biological applications of quantum dots
US7250499	18 Nov 2003	31 Jul 2007	Nanosphere Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US7259252	10 Oct 2001	21 Ago 2007	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US7314764	7 Mar 2006	1 Ene 2008	The Regents of the University of California	Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US20010023078	12 Abr 2001		Massachusetts Institute of Technology	Biological applications of quantum dots
US20010040232	29 May 2001		Massachusetts Institute of Technology	Water-soluble fluorescent nanocrystals
US20020066401	4 Oct 2001			Synthesis of colloidal nanocrystals
US20020071952	8 Dic 2000			Preparation of nanocrystallites
US20020072234	12 Feb 2001			Semiconductor nanocrystal probes for biological applications and process for making and using such probes
US20020146714	12 Sep 2001			Direct haplotyping using carbon nanotube probes
US20030017264	17 Jul 2002			Luminescent nanoparticles and methods for their preparation
US20030042850	3 Sep 2002			Electroluminescent device comprising quantum dots
US20030099968	24 May 2002			Semiconductor nanocrystal probes for biological applications and process for making and using such probes
US20030100130	24 May 2002			Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US20030113709	30 Oct 2002			Semiconductor nanocrystal-based cellular imaging
US20030209105	6 Jun 2003		Massachusetts Institute of Technology, a Massachusetts corporation	Preparation of nanocrystallites
US20040036085	6 Ago 2003		Hitachi Software Engineering Co., Ltd.	Functional fluorescence reagent comprising semiconductor nanoparticles
US20040104973	1 Jul 2003			FLUID INJECTION HEAD STRUCTURE
US20040265622	24 Jun 2003		Eastman Kodak Company	Light emitting display
US20050020922	6 Feb 2004			Materials and methods for near-infrared and infrared intravascular imaging
US20050020923	6 Feb 2004			Materials and methods for near-infrared and infrared lymph node mapping
US20050038498	29 Jul 2004		Nanosys, Inc.	Medical device applications of nanostructured surfaces
US20050113697	23 Nov 2004			Method of imaging lymphatic system using nanocapsule compositions
US20050118631	3 Nov 2004		Massachusetts Institute of Technology	Biological applications of quantum dots
US20050175540	23 Ene 2004			High contrast optoacoustical imaging using nonoparticles
US20050220714	21 Mar 2005			Agents for use in magnetic resonance and optical imaging

Reclamaciones

1. A semiconductor nanocrystal composition, comprising:

a) a core comprising a first semiconductor material;

b) a core-overcoating shell comprising a second semiconductor material, wherein the core and the core-overcoating shell form a core/shell nanocrystal; and

c) an encapsulating net surrounding the core/shell nanocrystal.

2. The semiconductor nanocrystal composition of claim 1, wherein said semiconductor nanocrystal composition is water-soluble.

3. The semiconductor nanocrystal composition of claim 1, wherein said semiconductor nanocrystal composition has a narrow emission wavelength band.

4. The semiconductor nanocrystal composition of claim 3, wherein said narrow emission wavelength band does not exceed 40 nm in width when measured at full width half maximum.

5. The semiconductor nanocrystal composition of claim 3, wherein said narrow emission wavelength band does not exceed about 20 nm in width when measured at full width half maximum.

6. The semiconductor nanocrystal composition of claim 1, wherein said encapsulating net comprises one or more linking agents capable of linking said core/shell nanocrystal to one or more affinity molecules.

7. The semiconductor nanocrystal composition of claim 6, wherein said one or more linking agents are polymerizable.

8. The semiconductor nanocrystal composition of claim 6, wherein said one or more linking agents comprise a thiol moiety.

9. The semiconductor nanocrystal composition of claim 6, wherein said one or more linking agents comprise an alkyl group.

10. The semiconductor nanocrystal composition of claim 1, wherein said core has a diameter from about 20 Å to about 100 Å.

11. The semiconductor nanocrystal composition of claim 1, wherein said core-overcoating shell is 1-10 monolayers thick.

12. The semiconductor nanocrystal composition of claim 1, wherein said core-overcoating shell epitaxially surrounds said core.

13. The semiconductor nanocrystal composition of claim 1, wherein said core/shell nanocrystal has an average cross-section that is no larger than about 20 nm.

14. The semiconductor nanocrystal composition of claim 1, wherein said core/shell nanocrystal has an average cross-section of about 1 nm to about 10 nm.

15. The semiconductor nanocrystal composition of claim 1, wherein said first semiconductor material comprises a Group II-VI semiconductor.

16. The semiconductor nanocrystal composition of claim 1, wherein said first semiconductor material comprises a Group III-V semiconductor.

17. The semiconductor nanocrystal composition of claim 1, wherein said first semiconductor material comprises MgS, MgSe, MgTe, CaS, CaSe, CaTe, SrS, SrSe, SrTe, BaS, BaSe, BaTe, ZnS, ZnSe, ZnTe, CdS, CdSe, CdTe, HgS, HgSe, or HgTe.

18. The semiconductor nanocrystal composition of claim 1, wherein said first semiconductor material comprises GaAs, InGaAs, InP, or InAs.

19. The semiconductor nanocrystal composition of claim 1, wherein said second semiconductor material comprises a Group II-VI semiconductor.

20. The semiconductor nanocrystal composition of claim 1, wherein said second semiconductor material comprises a Group III-V semiconductor.

21. The semiconductor nanocrystal composition of claim 1, wherein said second semiconductor material comprises MgS, MgSe, MgTe, CaS, CaSe, CaTe, SrS, SrSe, SrTe, BaS, BaSe, BaTe, ZnS, ZnSe, ZnTe, CdS, CdSe, CdTe, HgS, HgSe, or HgTe.

22. The semiconductor nanocrystal composition of claim 1, wherein said second semiconductor material comprises GaAs, InGaAs, InP, or InAs.

23. The semiconductor nanocrystal composition of claim 1, wherein said first semiconductor material comprises CdSe and the second semiconductor material comprises ZnS.

24. A semiconductor nanocrystals composition, comprising:

a) a core comprising a first semiconductor material;

b) a core-overcoating shell comprising a second semiconductor material, wherein the core and the core-overcoating shell form a core/shell nanocrystal; and,

c) an encapsulating net surrounding the core/shell nanocrystal;

wherein the core has an average cross-section no larger than 20 nanometers.

25. The semiconductor nanocrystal composition of claim 24, wherein said core has an average cross-section no larger than 10 nanometers.

26. The semiconductor nanocrystal composition of claim 24, wherein said nanocrystal core has an average cross-section in a range of from 1 nanometer to 10 nanometers.

27. The semiconductor nanocrystal composition of claim 24, wherein said encapsulating net comprises one or more linking agents capable of linking said core/shell nanocrystal to one or more affinity molecules.

28. The semiconductor nanocrystal composition of claim 27, wherein said one or more linking agents are polymerizable.

29. The semiconductor nanocrystal composition of claim 27, wherein said one or more linking agents comprise a thiol moiety.

30. The semiconductor nanocrystal composition of claim 27, wherein said one or more linking agents comprise an alkyl group.

31. The semiconductor nanocrystal composition of claim 24, wherein said first semiconductor material comprises a Group II-VI semiconductor.

32. The semiconductor nanocrystal composition of claim 24, wherein said first semiconductor material comprises a Group III-V semiconductor.

33. The semiconductor nanocrystal composition of claim 24, wherein said first semiconductor material comprises MgS, MgSe, MgTe, CaS, CaSe, CaTe, SrS, SrSe, SrTe, BaS, BaSe, BaTe, ZnS, ZnSe, ZnTe, CdS, CdSe, CdTe, HgS, HgSe, or HgTe.

34. The semiconductor nanocrystal composition of claim 24, wherein said first semiconductor material comprises GaAs, InGaAs, InP, or InAs.

35. The semiconductor nanocrystal composition of claim 24, wherein said second semiconductor material comprises a Group II-VI semiconductor.

36. The semiconductor nanocrystal composition of claim 24, wherein said second semiconductor material comprises a Group III-V semiconductor.

37. The semiconductor nanocrystal composition of claim 24, wherein said second semiconductor material comprises MgS, MgSe, MgTe, CaS, CaSe, CaTe, SrS, SrSe, SrTe, BaS, BaSe, BaTe, ZnS, ZnSe, ZnTe, CdS, CdSe, CdTe, HgS, HgSe, or HgTe.

38. The semiconductor nanocrystal composition of claim 24, wherein said second semiconductor material comprises GaAs, InGaAs, InP, or InAs.

39. The semiconductor nanocrystal composition of claim 24, wherein said first semiconductor material comprises CdSe and the second semiconductor material comprises ZnS.

Patentes

Semiconductor nanocrystal probes for biological applications and process for ...

Citas

Reclamaciones

Dibujos