US8195293B2 - Detecting ventricular noise artifacts in an active implantable medical device for pacing, resynchronization and/or defibrillation of the heart - Google Patents
Detecting ventricular noise artifacts in an active implantable medical device for pacing, resynchronization and/or defibrillation of the heart Download PDFInfo
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- US8195293B2 US8195293B2 US11/750,494 US75049407A US8195293B2 US 8195293 B2 US8195293 B2 US 8195293B2 US 75049407 A US75049407 A US 75049407A US 8195293 B2 US8195293 B2 US 8195293B2
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/37—Monitoring; Protecting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
- A61N1/36585—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by two or more physical parameters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/37—Monitoring; Protecting
- A61N1/3718—Monitoring of or protection against external electromagnetic fields or currents
Definitions
- the present invention relates to “active implantable medical devices” as such devices are defined by the Jun. 20, 1990 Directive 90/385/GEE of the Counsel of the European Community, and more particularly to implantable devices that continuously monitor a patient's heart rhythm, and deliver to the heart, if need be, electrical pulses for pacing, resynchronization, cardioversion and/or defibrillation, in the case of a detection by the device of a heart rhythm disorder.
- EGM electrogram
- IMD implantable device
- rhythm analysis and therefore the decision to deliver or not a therapy, may be altered by artifacts collected by the endocardial lead.
- a first series of artifacts corresponds to such situations when the device not only detects the event as such, i.e, the depolarization wave of the considered cavity, but also a disturbance that is associated with that same event and considered, erroneously, as another event occurring after said first event: e.g., a late depolarization wave, cross-talk between the two cavities, etc.
- Another series of artifacts are those to which the present invention is directed, namely artifacts of extrinsic noise not related to the myocardium depolarization.
- This noise can have various origins: notably, the myopotentials associated with muscular contractions, as well as electromagnetic interference (EMI) coming from different electronic equipment, such as surveillance devices, current daily-life devices, electro-surgical devices, communication systems, etc.
- EMI electromagnetic interference
- Such noise if present with more or less regularity, can then be detected by the IMD as a myocardium depolarization, with a risk to generate inappropriate therapies, for instance by erroneously inhibiting the antibradycardia pacing therapy or resynchronization therapy, or, conversely, by erroneously delivering inappropriate shocks.
- VF ventricular fibrillation
- the amplitude of VF signals may have a variable level comprised between the level of noise signals likely to be sensed by the IMD, and that of the signals of sinus complexes. If ventricular fibrillation has to be sensed, the sensing of a potential noise therefore cannot be avoided. If, moreover, a steady noise is present, with a patient presenting a normal cardiac sinus rhythm, such noise may be confused with depolarizations.
- That situation may distort the evaluation of the average rhythm by the IMD, such rhythm being evaluated at a level much higher than reality, with a correlative risk for applying an undesirable antitachycardia therapy (false positive).
- the IMD is set with too low a sensitivity, that is with a sensing threshold too high, the true episodes of ventricular fibrillation may not be sensed (false negative), with consequences that are much more severe towards the patient.
- the present invention is directed to overcoming the problem of discriminating such noise from cardiac depolarizations, in order to prevent triggering of inappropriate therapies caused by this noise of external origin.
- the starting point of the present invention lies in the observation that the depolarization, which is an electrical phenomenon that is sensitive to noise, is usually followed by a cardiac contraction, which is a mechanical phenomenon that is not affected by noise.
- a cardiac contraction which is a mechanical phenomenon that is not affected by noise.
- Sensing the mechanical activity of the heart is known and can preferably be operated through the measurement of endocardial acceleration, by means of an accelerometer placed directly in contact with the heart muscle (usually level with the right ventricular apex). Indeed, it is known that endocardial acceleration reflects very precisely, and in real-time, the phenomena concurring to the mechanical operation of the heart.
- the issued European patent EP 0,515,319, and its U.S. counterpart U.S. Pat. No. 5,304,208 (assigned to Sorin Biomedica S.p.A.) teach structure and techniques to collect an endocardial acceleration signal by using an endocardial lead equipped with a distal pacing electrode implanted into the ventricle and integrating a micro-accelerometer allowing to measure the endocardial acceleration.
- the endocardial acceleration signal thus collected during a cardiac cycle notably presents two peaks corresponding to the two major noises that can be identified along each cycle of a normal heart:
- the principle is to detect the presence or absence of a heart contraction, based upon the principle that each true heart cycle corresponds to one single cardiac contraction.
- the endocardial acceleration is analyzed, advantageously by detecting the presence or absence of a PEA I peak, to confirm the presence of a mechanical activity of the heart upon detection of a depolarization: such a detection that would not be followed by a mechanical activity of the heart may have been generated by noise. It is therefore suspect and shall not systematically lead to application or inhibition (depending on the case) of a therapy.
- the device of the present invention is of the same type as that described in EP 0,655,260 and U.S. Pat. No. 5,496,351 cited above, i.e., a device comprising:
- the device also includes means for searching for ventricular noise artifacts, comprising means for receiving as input, and correlating together, said signals representative of the depolarizations and said signals representative of the peaks of endocardial acceleration and, in case of lack of correlation, de-liver a signal of suspicion of ventricular noise.
- the device also can include means for modifying an operating parameter of said means for sensing the patient's heart rhythm, in response to the delivery of a signal of suspicion of ventricular noise.
- the operating parameter can preferably be a sensing threshold of the sensing circuit, modified so as to be increased in response to the delivery of a signal of suspicion of ventricular noise.
- the operating parameter can be the parameter of a digital filter of the sensing circuit, modified toward a more restrictive filtering in response to the delivery of a signal of suspicion of ventricular noise.
- the operating parameter is preferably being modified for a predetermined duration, or during a predetermined number of cycles, following the delivery of the signal of suspicion of ventricular noise. Preferably, however, the operating parameter is restored to its previous value in case of a suspicion of arrhythmia.
- the suspicion of arrhythmia can preferably arise from analyzing the successive ventricular and atrial depolarizations, or from use of means for sensing of an acceleration of the peaks of cardiac contractions, e.g., PEAs.
- the device can preferably comprise two distinct endocardial leads, one equipped with said endocardial electrode, the other with said endocardial acceleration sensor.
- the delivery of a signal of suspicion of ventricular noise is notably conditioned by the detection:
- the acceleration sensor can be a sensor able to assess the acceleration level with a ventricle, an atrium, or a peripheral heart blood vessel.
- FIG. 1 is a time diagram showing, over three successive cardiac cycles, the variations of the endocardial acceleration as well as the electrogram and surface electrocardiogram;
- FIG. 2 is a time diagram, showing, over six successive cardiac cycles: (i) the different collected signals representative of successive depolarizations, (ii) the signal indicating the presence of an endocardial acceleration peak, and (iii) the changes brought to the sensing sensitivity in the presence of noise; and
- FIG. 3 is a flowchart showing the successive different steps of analysis for the implementation of the invention.
- FIGS. 1-3 One will now describe a preferred embodiment of the device of this invention, with reference to FIGS. 1-3 .
- the present invention can be implemented by an appropriate programming of the soft-ware of a known active implantable device, for example, of the pacemaker or defibrillator/cardiovertor type, comprising means for acquiring a signal provided by endocardial leads and/or one or more implanted sensors.
- the invention can notably be applied to the implantable devices ELA Symphony and Rhapsody pacemakers marketed by ELA Medical, Montrouge, France.
- These devices are equipped with programmable microprocessors, including circuits intended to acquire, format and process electrical signals collected by implanted electrodes, and deliver pacing pulses to these electrodes. It is also possible to upload towards these devices, by telemetry, software routines (updates, enhancements and new programs), that will be stored in internal memory and run so as to implement, among other things, the features of the invention, described in more detail below. Implementing the features of the invention into these devices is deemed to be within the abilities of a person of ordinary skill in the art, and will therefore not be described in detail in this document.
- the upper curve shows the variations of endocardial acceleration (EA), measured through a sensor of the type described in EP 0,515,319 and U.S. Pat. No. 5,304,208 cited above, embedded in the tip of an endocardial lead placed in the apex of the ventricle.
- EA endocardial acceleration
- FIG. 1 also shows the electrogram (EGM) traces, i.e., of the electrical signal collected through the distal electrode of the same lead, and a corresponding surface electrocardiogram (ECG), over three successive cardiac cycles.
- EMG electrocardiogram
- the trace of acceleration presents two successive complexes or peaks of endocardial acceleration (PEA), parameters of which (amplitude, width and time position, that is: moment of occurrence) can be determined by an appropriate processing of the signal provided by the acceleration sensor, as described in EP 0,655,260 and U.S. Pat. No. 5,496,351 cited above.
- the present invention proposes to use the parameters correlated to the endocardial acceleration thus collected, preferably the occurrence of PEA I peak (indicated by the time position of this peak), in order to confirm or not the presence of a mechanical activity of the heart.
- the first line of FIG. 2 shows the succession of atrial (P) and ventricular (R) events, over six successive cardiac cycles, for a patient presenting a normal sinus rhythm.
- Collection of these signals may be disturbed by the sensing of extrinsic ventricular noises that can be seen as artifacts, such as those illustrated in X and Y, likely to be (wrongly) interpreted by the IMD as ventricular events leading to an erroneous suspicion of a brutal increase of the ventricular rate, similar to what could happen in case of ventricular fibrillation.
- the steady character of the contractions allows one to obviate the suspicion of ventricular fibrillation and to qualify the suspect events X and Y as artifacts.
- the first step ( 10 ) consists of collecting in a continuous way, the endocardial acceleration signals and the ventricular depolarizations (V), the analysis being performed for each cardiac cycle.
- the device determines, based upon those measurements, a first series of signals representative of the ventricular depolarizations, and a second series of signals representative of the acceleration peaks (PEA) (preferably the PEA I peak).
- PEA acceleration peaks
- the first phase of the analysis determines whether the PEA signals are stable in amplitude and/or in coupling intervals (the coupling interval being the time period between two peaks relating to successive cycles).
- the condition of stability in amplitude means, for example, that the PEA I peak amplitude does not vary by more than x % compared to the average of the previous y cycles.
- the condition of stability of coupling intervals means, for example, that the coupling interval does not vary by more or less z milliseconds, for instance plus or minus 30 milliseconds from one cycle to the next.
- the device determines (step 14 ) whether the rate of these con-tractions (frequency of PEA peaks (f PEA )) is lower than a limiting rate, lower than the detection zone of tachycardiae (f tachycardiae ).
- the heart rhythm is probably a confirmed tachycardia, for which a therapy shall be considered, with no need to perform the analysis any further.
- the device examines (step 16 ) whether it is in presence of a series of ventricular events with a short and variable coupling interval (the criterion of “short coupling” means that the coupling intervals between successive ventricular events are lower than a given threshold, and the criterion of “variable coupling” means that the differences between the coupling intervals are higher than a given threshold over a predetermined number of successive cycles).
- step 18 If the analysis of the ventricular depolarizations reveals (at step 16 ) a fast and unstable rhythm, then ventricular noise is suspected (step 18 ).
- the sensitivity of the ventricular sensing circuit is reduced (which means the sensitivity threshold is increased) for a predetermined period of time (time being defined in terms of duration or in terms of a number of cycles). It can be noted that in the alternative or optionally also some other operating parameters of the sensing circuits may be modified in case of suspected ventricular noise, notably the adjustment of the circuits or filtering algorithms.
- the detection of arrhythmiae can notably be implemented through the algorithm “PARAD” (registered trade mark of ELA Medical), which is a diagnostic algorithm, notably described in issued European patents EP 0,626,182 and EP 0,838,235 and their respective U.S. counterparts U.S. Pat. Nos. 5,462,060 and 5,868,793 (commonly assigned herewith to ELA Medical), to which one seeking for further details may refer.
- PARAD registered trade mark of ELA Medical
- That detection can also be implemented through the detection of an acceleration of the cardiac contraction peaks: for example, an acceleration of 25% of the average of the previous 8 intervals will be considered as a situation corresponding to a suspicion of arrhythmia.
- the detection of noise can be used to modify the sensing algorithms associated with ventricular therapies so as to prevent delivery of inappropriate therapies.
- the treatment of an arrhythmia that presents more than a given percentage (e.g. 50%) of “noisy” cycles may be delayed by a preselected time period, which time period can be greater or lesser depending on a corresponding greater or lesser amount of detected noise, i.e., a time period whose duration varies as function of the percentage of noisy cycles detected in a given interval or number of cycles.
Abstract
Description
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- the first endocardial acceleration peak (“PEA I”) corresponds to the closure of mitral and tricuspid valves, at the beginning of the phase of isovolumetric ventricular contraction (systole). The variations of this first peak are closely related to pressure variations in the ventricle (the amplitude of PEA I peak, being more precisely correlated to the positive maximum of pressure variation, dP/dt, in the left ventricle) and can therefore constitute a representative parameter for myocardium contractility.
- The second peak of endocardial acceleration (“PEA II”) corresponds to the closure of aortic and pulmonary valves, at the beginning of the diastole. It is produced by the brutal deceleration of moving blood mass in the aorta.
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- means for sensing a patient's heart rhythm comprising at least one endocardial electrode able to collect the electrical potential related to the myocardium depolarizations, and a sensing circuit able to analyze the collected potentials and deliver a sequence of signals representative of the successive ventricular and atrial depolarizations, and
- means for sensing the myocardium contractions comprising an endocardial acceleration sensor, and means for determining at least one peak of endocardial acceleration over one given cardiac cycle and delivering a sequence of signals representative of successive acceleration peaks.
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- of a sequence of acceleration peaks with a stable amplitude and/or stable coupling intervals,
- of a sequence of acceleration peaks with a frequency that is lower than a limiting value representative of a threshold of detection of tachycardiae, and/or
- of a sequence of depolarizations presenting successive coupling intervals that are short and variable.
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- an atrium,
- the left ventricle,
- a blood vessel that is peripheral to the heart, that is a vessel located on the heart, or at immediate proximity thereof (in contact with the heart wall).
Claims (20)
Applications Claiming Priority (3)
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FR0604446 | 2006-05-18 | ||
FR06-04446 | 2006-05-18 | ||
FR0604446A FR2901146A1 (en) | 2006-05-18 | 2006-05-18 | ACTIVE IMPLANTABLE MEDICAL DEVICE FOR CARDIAC STIMULATION, RESYNCHRONIZATION, CARDIOVERSION AND / OR DEFIBRILLATION, COMPRISING MEANS FOR DETECTING VENTRICULAR NOISE ARTEFACTS |
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Publication Number | Publication Date |
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US20070282379A1 US20070282379A1 (en) | 2007-12-06 |
US8195293B2 true US8195293B2 (en) | 2012-06-05 |
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US11/750,494 Active 2030-06-04 US8195293B2 (en) | 2006-05-18 | 2007-05-18 | Detecting ventricular noise artifacts in an active implantable medical device for pacing, resynchronization and/or defibrillation of the heart |
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US (1) | US8195293B2 (en) |
EP (1) | EP1857142B1 (en) |
AT (1) | ATE390171T1 (en) |
DE (1) | DE602007000007T2 (en) |
FR (1) | FR2901146A1 (en) |
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ATE390171T1 (en) | 2008-04-15 |
EP1857142B1 (en) | 2008-03-26 |
US20070282379A1 (en) | 2007-12-06 |
DE602007000007D1 (en) | 2008-05-08 |
EP1857142A1 (en) | 2007-11-21 |
DE602007000007T2 (en) | 2009-06-18 |
FR2901146A1 (en) | 2007-11-23 |
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