Búsqueda Imágenes Maps Play YouTube Noticias Gmail Drive Más »
Iniciar sesión
Usuarios de lectores de pantalla: deben hacer clic en este enlace para utilizar el modo de accesibilidad. Este modo tiene las mismas funciones esenciales pero funciona mejor con el lector.

Patentes

  1. Búsqueda avanzada de patentes
Número de publicaciónUS8329271 B2
Tipo de publicaciónConcesión
Número de solicitudUS 11/792,722
Número de PCTPCT/GB2005/004834
Fecha de publicación11 Dic 2012
Fecha de presentación14 Dic 2005
Fecha de prioridad23 Dic 2004
TarifaPagadas
También publicado comoDE602005027392D1, EP1833540A1, EP1833540B1, US20080107848, WO2006067383A1
Número de publicación11792722, 792722, PCT/2005/4834, PCT/GB/2005/004834, PCT/GB/2005/04834, PCT/GB/5/004834, PCT/GB/5/04834, PCT/GB2005/004834, PCT/GB2005/04834, PCT/GB2005004834, PCT/GB200504834, PCT/GB5/004834, PCT/GB5/04834, PCT/GB5004834, PCT/GB504834, US 8329271 B2, US 8329271B2, US-B2-8329271, US8329271 B2, US8329271B2
InventoresRaymond Bacon
Cesionario originalClinical Designs Limited
Exportar citaBiBTeX, EndNote, RefMan
Enlaces externos: USPTO, Cesión de USPTO, Espacenet
Medicament container
US 8329271 B2
Resumen
A medicament source has a container and a crimped closure. The closure sealingly holds to the container a metered-dose release valve, of which the spout only is visible externally. The container has a neck and a protruding rim at which the crimp locates. The container is of molded polymer and has an outer, perforate sleeve of aluminum, providing mechanical strength for pressure retention. The neck has a relatively thicker wall thickness and the end is domed inwards, both for pressure retention. The polymer is of three layers or laminations. The innermost layer is of polytetrafluoroethylene (PTFE) material to provide an inert layer with which the medicament and its propellant will not react or combine in any way. The middle polymer layer is of nylon material to provide a propellant tight layer, to contain the propellant, whose molecules may be able to pass through the PTFE layer. The outer polymer layer is of polypropylene (PP) to provide both water tightness and mechanical integrity of the container.
Imágenes(4)
Previous page
Next page
Reclamaciones(14)
1. A container comprising a pressurised medicament for use in a medicament source,
the container comprising a mouth with a rim for a closure of the medicament source,
the container comprising a plurality of layers comprising:
a first, inner, substance-repellent layer to repel the medicament;
a second gas-tight layer; and
a third, liquid-impermeable layer;
wherein said layers are of a polymeric material and
said layers are of transparent or translucent material, and
the container comprising the pressurised medicament comprises a pressurised propellant and a reinforcing layer including fibre reinforcement to retain the pressure of the pressurised medicament.
2. A container as claimed in claim 1, wherein the gas tight layer is inside the liquid-impermeable layer.
3. A container as claimed in claim 1, wherein the gas tight layer is outside the liquid-impermeable layer.
4. A container comprising a pressurised medicament for use in a medicament source,
the container comprising a mouth with a rim for a closure of the medicament source, and
the container comprising a plurality of layers comprising:
an inner, substance-repellent layer to repel the medicament; and
an outer gas-tight and liquid-impermeable layer;
wherein said layers are of polymeric material and
said layers are of transparent or translucent material and the container comprising the pressurised medicament comprises a pressurised propellant and a reinforcing layer including fibre reinforcement to retain the pressure of the pressurised medicament.
5. A container as claimed in claim 4 or claim 1, including a welded closure or a crimp closure.
6. A container as claimed in claim 4 or claim 1, wherein the container is moulded and the reinforcing layer is incorporated in a post-moulding addition to the container.
7. A container as claimed in claim 4 or claim 1, wherein the reinforcing layer is incorporated into the container as moulded.
8. A container as claimed in claim 4 or claim 1, wherein the reinforcing layer is perforate, of open weave textile or spirally wound for visual assessment of the level of the medicament within the container.
9. A container as claimed in claim 4 or claim 1, wherein said inner layer comprises polytetrafluoroethylene.
10. A container as claimed in claim 4 or claim 1, wherein said gas-tight layer comprises nylon.
11. A container as claimed in claim 4 or 1, wherein the reinforcing layer includes a pressure retaining sleeve surrounding said plurality of polymeric layers.
12. The container of claim 11 wherein said sleeve is perforated.
13. The container of claim 12 wherein said sleeve is aluminium.
14. A method of moulding a container as claimed in claim 4 or claim 1, the method consisting in the steps of:
injection moulding a laminated preform,
including a reinforcing layer including fibre reinforcement in a blowing mould, and
blowing the preform to finished shape in the mould.
Descripción

This application is the US national phase of international application PCT/GB2005/004834 filed 14 Dec. 2005, which designated the U.S. and claims benefit of GB 0428204.2, filed 23 Dec. 2004, the entire contents of each of which are hereby incorporated by reference.

The present invention relates to a container for a medicament, particularly of not exclusively for use in a pressurised source of a medicament.

Sources of medicament having metered dose release valves conventionally are provided with aluminium containers of the medicament. As such, the user cannot see the amount of medicament left.

Expensive counters for counting the number of operations of the valve are coming to be provided to enable the user to assess the number of doses remaining.

The object of the present invention is to provide an alternative means of providing this assessment, namely visually.

According to a first aspect of the invention there is provided a container for a medicament in a medicament source, the container having:

    • a mouth with a rim for a closure of the medicament source,
      the container including a plurality of layers of polymeric material, the layers comprising at least:
    • an inner, substance-repellent layer;
    • an outer gas-tight and liquid-impermeable layer,
      the two layers being of transparent or at least translucent material.

According to a second aspect of the invention there is provided a container for a medicament in a medicament source, the container having:

    • a mouth with a rim for a closure of the medicament source,
      the container including a plurality of layers of polymeric material, the layers comprising at least:
    • an inner, substance-repellent layer;
    • a second, gas-tight layer; and
    • a third, liquid-impermeable layer,
      the three layers being of transparent or at least translucent material.

The gas tight layer can be inside the liquid-impermeable layer or outside it.

Whilst other forms of closure can be envisaged, in particular welded closures, the usual closure is expected to be a crimp closure.

The inner layer is provided to avoid wetting of the inside surface of the container by the medicament or adsorption of it by the container's material. Suitably, polytetrafluoroethylene can be used for the inner layer.

The second gas-tight layer is provided to retain the medicament against permeation through the container under pressure and also to retain a propellant, within the container, where as is normally the case, the container is being used in a pressurised source of the medicament. Suitably, nylon can be used for the second layer.

The third layer is provided to retain the liquid carrier of the medicament, which will normally be water. Suitably, polypropylene can be used for the third layer. An further purpose of the third layer is to stop ingress of water from without the container, in particular where the medicament can degrade in the presence of water

A reinforcing layer may be provided. This may be a perforate metallic layer or a fibre reinforcement. The reinforcing layer may be added after moulding formation of the container or may be incorporated into the container during moulding.

The reinforcing layer will normally be perforate, open weave textile or possibly spirally wound, in order that the level of the medicament within the container can be assessed.

According to a third aspect of the invention, there is provided a method of producing the container of the first aspect, the method consisting in the steps of

    • injection moulding a laminated preform and
    • blowing the preform to finished shape.

The reinforcing layer can be included in the blowing mould prior to blowing of the preform to shape to suit.

To help understanding of the invention, a specific embodiment thereof will now be described by way of example and with reference to the accompanying drawings, in which:

FIG. 1 is a side view of a metered-dose, source of a medicament, the source including a container according to the invention;

FIG. 2 is a similar cross-sectional side view of the container of the source of FIG. 1;

FIG. 3 is a similar view of a preform for the container of FIG. 2;

FIG. 4 longitudinal cross-sectional view of an injection moulding tool configured for injection of the inner layer of the container;

FIG. 5 is a similar view of the too 1 configured for injection of the second layer;

FIG. 6 is a third view of the tool configured for injection of the third layer; and

FIG. 7 is a similar view of the injection moulded preform blown to size in a blow moulding cavity.

Referring to the drawings, the medicament source 1 of FIG. 1 has a container 2 of the invention and a crimped closure 3. The closure sealingly holds to the container a metered-dose release valve, of which the spout 4 only is visible in FIG. 1.

As shown in FIG. 2, the container has a neck 5 and a protruding rim 6 at which the crimp locates. The container is of moulded polymer 7 and has an outer, perforate sleeve 8 of aluminium sleeve, providing mechanical strength for pressure retention. The neck has a relatively thicker wall thickness of polymer, enabling pressure retention and the polymer end 9 is domed inwards, also for pressure retention.

The polymer is of three layers or laminations. The innermost layer 11 is of polytetrafluoroethylene (PTFE) material. This is provided as an inert layer with which the medicament and its propellant will not react or combine in any way. The middle polymer layer is of nylon material. This is provided as a propellant tight layer 12, to contain the propellant, whose molecules may be able to pass through the PTFE layer. The outer polymer layer 14 is of polypropylene (PP). It is thicker than the other two layers to provide both water tightness and mechanical integrity of the container. The three polymer layers are in intimate contact with each other and the PP layer is in intimate contact with the aluminium.

Referring now to FIGS. 3 and 4, the container 2 is formed as a blow moulding from the preform shown in FIG. 3, the preform being injection moulded in the tool shown in FIG. 4. The preform is a shorter, squatter configuration of the container, and as such will not be separately described, save to say that its layers are designated as follows:

inner PTFE layer 21

middle nylon layer 22

outer PP layer 24.

The operative parts only of the mould tool 25 are shown and comprise a male part 26 and a female part 27. The male part is conventional in having no moving parts, except for an expulsion air tappet valve 261 mounted in a male core part 262, the latter being integral with a backing plate 263. The female part on the other hand has several moving parts, including a central gate part 271, with three gates 2721 for PTFE, 2722 for nylon and 2723 for PP. The gate part is movable by the respective thickness of the layers 22 and 24, in other words for injection and moulding of the PTFE layer the central part is advanced towards the male core part 262 and spaced from it by the thickness of the PTFE layer. Then for injection of the nylon layer, the central part is withdrawn by the thickness of the nylon part and for injection of the PP layer it further withdrawn by the thickness of the PP layer. The mechanical and hydraulic details of the design of the central part and the mould tool in general are expected to be within the capabilities of the skilled man and as such will not be described in more detail.

Coaxial with the male core part 262 and the female gate part 271 are three sleeves 273, 274, 275, all individually and selectively withdrawable away from the male backing plate 263. The first sleeve is in its advanced position shown in FIG. 4 for moulding of the PTFE layer 21. This is moulded in the cavity formed between the male core part, the female gate part and the sleeve 273. For moulding of the nylon layer, the sleeve 273 is withdrawn as is the gate part 271 to its first withdrawn position. A mould cavity now exists between the PTFE layer 21, sleeve 274 and the gate part and the nylon layer is injected into this, see FIG. 5.

Both the PTFE and nylon layers are circular cylindrical, open at one end and closed at the other. The PP layer is similar saving having the shoulder or rim 6. To form this, not only is the sleeve 274 withdrawn, but also the outer sleeve 275 is partially withdrawn. Thus the mould cavity is formed to a shape suitable for moulding the PP layer complete with its shoulder, see FIG. 6. The circumference of the shoulder is formed against a fixed part 277 of the female mould part.

The resultant moulding is ejected from the injection moulding tool and transferred to the blow moulding tool 301, shown in FIG. 7. This a largely conventional tool, save that it is provided with a reinforcing sleeve 8 prior to insert of the preform. This is gripped at it shoulder 6 by mould features 302 and stretched by a rod 303 to its full use length. Gas is injected into the preform via drillings 304 in the rod and the preform is blown to its full diameter, in which the PP layer comes into intimate contact with the aluminium sleeve.

The invention is not intended to be restricted to the details of the above described embodiment. For instance, other polymers having like properties respectively to PTFE, nylon and PP may be used. Again other reinforcements such as fibre reinforcement can be used. Further it is envisaged that no reinforcement may be necessary. Again other processes than preform and blow moulding may be used for making containers of the invention.

Further, the invention is equally as applicable to non-metered dose pressurised sources of a medicament using a container of the invention as metered dose sources.

Citas de patentes
Patente citada Fecha de presentación Fecha de publicación Solicitante Título
US200283511 May 193428 May 1935Rose William HSiphon device
US271601327 May 195023 Ago 1955Tinker Theodore BFlexible valve structure
US29226131 Jun 195126 Ene 1960Cutter LabPinch valve
US310333528 Mar 196110 Sep 1963Resiflex Lab IncUnitary clamp means for flexible tubes
US319049728 May 196222 Jun 1965Warner Lambert PharmaceuticalLiquid collecting apparatus and a valve therefor
US33293899 Mar 19644 Jul 1967Plastronics IncValve for controlling flow through a flexible tube
US359828826 Jun 196910 Ago 1971Posgate Edward SFlexible tube-metering devices
US374619629 Ene 197117 Jul 1973Green Cross CorpCoated plastic container for liquid medicine
US414265129 Abr 19776 Mar 1979Norbert LeopoldiFluid dispenser with flexible outlet tube and pinching valve
US43611483 Dic 198030 Nov 1982Cutter Laboratories, Inc.Flexible conduit with releasable sealing means
US437036829 Abr 198125 Ene 1983Toyo Seikan Kaisha, Ltd.Plastic bottles and process for preparation thereof
US439310628 Oct 198112 Jul 1983Toyo Seikan Kaisha Ltd.Laminated plastic container and process for preparation thereof
US448637812 Abr 19844 Dic 1984Toyo Seikan Kaisha Ltd.Plastic bottles and process for preparation thereof
US457615724 Oct 198318 Mar 1986Raghuprasad Puthalath KOral inhalation apparatus
US466410725 Oct 198412 May 1987Minnesota Mining And Manufacturing CompanyInhalation activatable dispensers
US475337127 Ago 198728 Jun 1988Serge MichielinFlow controlled and container
US481782224 Abr 19874 Abr 1989Glaxo Group LimitedIndicating device
US49553718 May 198911 Sep 1990Transtech Scientific, Inc.Disposable inhalation activated, aerosol device for pulmonary medicine
US498415814 Oct 19888 Ene 1991Hillsman DeanMetered dose inhaler biofeedback training and evaluation system
US502052720 Feb 19904 Jun 1991Texax-Glynn CorporationInhaler device with counter/timer means
US50316103 May 198816 Jul 1991Glaxo Inc.Inhalation device
US504268510 Ago 198927 Ago 1991Moulding Jr Thomas SDispensing having a compartment for detecting and counting the dispensed objects especially adapted for dispensing medication and method of using the same
US5049345 *9 Nov 198917 Sep 1991Continental Pet Technologies, Inc.Method of forming a multi-layer preform
US506920417 Ago 19903 Dic 1991Riker Laboratories, Inc.Inhaler
US511980614 Dic 19899 Jun 1992Glaxo Inc.Inhalation device
US51524563 Dic 19906 Oct 1992Bespak, PlcDispensing apparatus having a perforate outlet member and a vibrating device
US518476117 Sep 19919 Feb 1993Bespak PlcDispensing apparatus
US51937457 Mar 199016 Mar 1993Karl HolmAtomizing nozzle device for atomizing a fluid and an inhaler
US521700413 Dic 19908 Jun 1993Tenax CorporationInhalation actuated dispensing apparatus
US52399921 Jun 199231 Ago 1993Societe Francaise D'aerosols Et De BouchageLoose powder inhaler with inhalation-actuated dosing piston
US52616016 Jul 199216 Nov 1993Bespak PlcLiquid dispensing apparatus having a vibrating perforate membrane
US52731729 Nov 199228 Dic 1993Marsteller & Killmann Gmbh & Co. KgClosure device for drinking from containers
US529547915 Abr 199122 Mar 1994Leiras OyDevice intended for measuring a dose of powdered medicament for inhalation
US529970119 Ago 19935 Abr 1994Senetics, Inc.Indicator cap
US53479988 Jul 199120 Sep 1994Minnesota Mining And Manufacturing CompanyBreath actuated inhaler having an electromechanical priming mechanism
US538857226 Oct 199314 Feb 1995Tenax Corporation (A Connecticut Corp.)Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same
US540899412 Nov 199125 Abr 1995Minnesota Mining And Manufacturing CompanyInhalation device
US541516115 Sep 199316 May 1995Ryder; Steven L.Intermittant demand aerosol control device
US542148222 Sep 19936 Jun 1995Senetics, Inc.Indicator device responsive to axial force
US548203013 Jun 19949 Ene 1996Klein; DavidAerosol and non-aerosol spray counter
US548737817 Dic 199130 Ene 1996Minnesota Mining And Manufacturing CompanyInhaler
US550137512 May 199426 Mar 1996Cenova Innovations & Produktions AbDispenser valve for dispensing a pressurized liquid
US551154018 Ago 199330 Abr 1996Minnesota Mining And Manufacturing CompanyInhalation device
US554464729 Nov 199413 Ago 1996Iep Group, Inc.Metered dose inhalator
US55446579 Sep 199413 Ago 1996Siemens Medical Systems, Inc.Ultrasound blood flow monitor of the non-doppler type
US554693224 Mar 199320 Ago 1996Tebro SaPowder jet dispenser for medicament inhalation therapies
US55491014 May 199327 Ago 1996Astra AktiebolagDosage inhalator with indicating/interrupting means
US554922622 Abr 199427 Ago 1996Kopp; VolkerDevice for operating devices for propellant cans
US556441426 May 199415 Oct 1996Walker; William F.Pressurized and metered medication dose counter on removable sleeve
US561144429 Mar 199518 Mar 1997Senetics, Inc.Indicator device responsive to axial force
US562216322 Nov 199522 Abr 1997Iep Group, Inc.Counter for fluid dispensers
US562392013 Jul 199329 Abr 1997Minnesota Mining And Manufacturing CompanyValve assemblies
US564505011 Dic 19928 Jul 1997Boehringer Ingelheim KgPowder inhaler with powder carrier consisting of regular microstructures
US568287526 Feb 19964 Nov 1997Fisons PlcAerosol device having a spout to prevent spray head blockage
US569249215 Feb 19942 Dic 1997Valois S.A.Hand-held inhalation-actuated spray device
US57183556 Jun 199517 Feb 1998Senetics, Inc.Indicator device responsive to axial force for use with inhaler
US57720858 Mar 199630 Jun 1998Minnesota Mining And ManufacturingFree flow aerosol valves
US57946122 Abr 199718 Ago 1998Aeromax Technologies, Inc.MDI device with ultrasound sensor to detect aerosol dispensing
US580999710 Oct 199522 Sep 1998Medtrac Technologies, Inc.Electronic medication chronolog device
US583942920 Ago 199724 Nov 1998Astra AktiebolagMethod and apparatus in connection with an inhaler
US587891712 Jul 19969 Mar 1999Schott GlasDevice for administering substances such as an inhalation preparation
US596060912 Jun 19985 Oct 1999Microdose Technologies, Inc.Metering and packaging method and device for pharmaceuticals and drugs
US59884969 Jun 199523 Nov 1999Valois S.A.Dose counter for inhalers
US59965779 Ago 19967 Dic 1999Unisia Jecs CorporationMedicine administering apparatus
US601497011 Jun 199818 Ene 2000Aerogen, Inc.Methods and apparatus for storing chemical compounds in a portable inhaler
US608574217 Abr 199811 Jul 2000Aeromax Technologies, Inc.Intrapulmonary delivery device
US614214612 Jun 19987 Nov 2000Microdose Technologies, Inc.Inhalation device
US614881510 Abr 199821 Nov 2000Medtrac Technologies, Inc.Electronic medication chronolog device
US614905419 Dic 199621 Nov 2000Boehringer Ingelheim International GmbhMechanical counter for a metering apparatus
US615213012 Jun 199828 Nov 2000Microdose Technologies, Inc.Inhalation device with acoustic control
US616449413 Mar 200026 Dic 2000Microsrpray Delta S.P.A.Liquid dose dispenser with device for counting a large number of dispensed doses
US619621824 Feb 19996 Mar 2001Ponwell Enterprises LtdPiezo inhaler
US620264223 Abr 199920 Mar 2001Medtrac Technologies, Inc.Electronic monitoring medication apparatus and method
US623416826 Jun 199722 May 2001Valois S.A.Dosimeter
US624091820 Feb 19975 Jun 2001Schering CorporationPowdered medication inhaler
US625376231 Mar 19973 Jul 2001Glaxo Wellcome Inc.Metered dose inhaler for fluticasone propionate
US626054918 Jun 199817 Jul 2001Clavius Devices, Inc.Breath-activated metered-dose inhaler
US62833658 Abr 19994 Sep 2001Neil Peter BasonIndicator device
US63183611 Oct 199920 Nov 2001Clavius Devices Inc.Breath-activated metered-dose inhaler
US63250621 Oct 19994 Dic 2001Clavius Devices, Inc.Breath-activated metered-dose inhaler
US633645330 Abr 19998 Ene 2002Trudell Medical InternationalIndicating device for aerosol container
US635429010 Dic 199912 Mar 2002Bespak PlcInhalation apparatus
US635744227 Oct 199819 Mar 2002Innovative Devices, LlcInhalation actuated device for use with metered dose inhalers (MDIS)
US63607398 Jun 199826 Mar 2002Smithkline Beecham CorporationDispenser with doses counter
US63978393 Mar 19994 Jun 2002TebroDispensing device for fluid product activated by inhaling
US640572722 May 199818 Jun 2002Pa Knowledge LimitedInhaler mechanism
US641578424 Sep 19999 Jul 2002Astrazeneca AbInhaler
US642223416 Mar 199823 Jul 2002Raymond John BaconAerosol dispensing device
US64253921 Oct 199930 Jul 2002Clavius Devices, Inc.Breath-activated metered-dose inhaler
US642768316 Ene 19986 Ago 2002Bo DrachmannAerosol inhaler device
US64311688 Jun 199813 Ago 2002Smithkline Beecham CorporationDispenser with doses′ counter
US643537214 Sep 200120 Ago 20021263152 Ontario Inc.Delivery system for a medicament and method for the assembly thereof
US643922712 Oct 200027 Ago 2002Microdrug AgBreath-actuation
US644314624 Feb 20003 Sep 2002Ponwell Enterprises LimitedPiezo inhaler
US644662718 Dic 199710 Sep 2002Norton Healthcare LimitedInhaler dose counter
US64605379 Nov 19998 Oct 20023M Innovative Properties CompanyBreath-actuated aerosol dispensers
US647088416 Abr 200129 Oct 2002Aventis Pharma LimitedCapsule opening arrangement for use in a powder inhaler
US64743318 Jun 19985 Nov 2002Smithkline Beecham CorporationDispenser with doses' counter
US65108477 Jul 200028 Ene 2003Astrazeneca AbDelivery device
US65167998 Sep 199911 Feb 2003Sapphire Design, Inc.Inhalation counter device
US654692815 May 200015 Abr 2003Smithkline Beecham CorporationMetered dose inhaler for fluticasone propionate
US65539889 Jun 200029 Abr 2003Norton Healthcare, Inc.Medicament dispensing device with a multimaterial diaphragm bounding a pneumatic force chamber
US658159021 Mar 200024 Jun 2003Iep Pharmaceutical Devices Inc.Inhalation actuated device
US659626010 Ago 199422 Jul 2003Novartis CorporationAerosol container and a method for storage and administration of a predetermined amount of a pharmaceutically active aerosol
US660158220 Ago 20025 Ago 2003Smithkline Beecham CorporationDispenser with doses' counter
US661582710 Abr 20029 Sep 2003Sapphire Designs, Inc.Inhalation counter device
US665537125 Jul 20022 Dic 2003Bear Archery, Inc.Archery bow having a swing arm cable guard with adjustably mounted cable saver
US665537911 Mar 19992 Dic 2003Nektar TherapeuticsAerosolized active agent delivery
US665930712 Oct 20009 Dic 2003Valois S.A.S.Dose counter and distributor of a fluid product incorporating a counter of this type
US667230424 Mar 20006 Ene 2004Innovative Devices, LlcInhalation actuated device for use with metered dose inhalers (MDIs)
US672933021 Mar 20024 May 2004Trudell Medical InternationalIndicating device for aerosol container
US674576119 Jun 20038 Jun 2004Astrazeneca AbInhaler
US675214519 Abr 200022 Jun 2004Smithkline Beecham CorporationMedication dispenser
US675215313 Ago 199922 Jun 2004Rpc Wiko Gmbh & Co. KgInhalator comprising a dosage counting device
US675519016 Mar 200129 Jun 2004Astrazeneca AbInhaler
US675910812 May 20006 Jul 2004Yoshino Kogyoshocco., Ltd.Laminated plastic molded body
US676622029 Jul 200220 Jul 2004Chrysalis Technologies IncorporatedMethod and apparatus for generating a volatilized liquid
US68051166 Ene 200319 Oct 2004Astrazeneca AbInhalation device
US682386316 Mar 200130 Nov 2004Astrazeneca AbInhaler
US686026224 Jun 20031 Mar 2005Astrazeneca AbInhaler
US686603716 Jun 200015 Mar 2005Shl Medical AbInhaler
US686603824 Ene 200215 Mar 2005Clinical Designs LimitedFiring flap dispenser
US68896872 Nov 200010 May 2005Shl Medical AbInhalator with aerosolizing unit
US690787628 Mar 200021 Jun 2005Bespak PlcDispensing apparatus comprising a dosage counting device
US692600224 Jun 20049 Ago 2005Trudell Medical InternationalIndicating device
US70076893 Nov 20037 Mar 2006Astrazeneca AbInhalation device
US703650524 Jul 20012 May 2006Clinical Designs Ltd.Dispenser
US704796424 Ene 200223 May 2006Clinical Designs Ltd.Dispenser for medicament
US704796716 Mar 200123 May 2006Astrazeneca AbInhaler
US70727382 Abr 20024 Jul 2006Glaxo Group LimitedMedicament dispenser
US709359424 Sep 200122 Ago 2006Pfizer LimitedDosing device
US710053016 Jun 20045 Sep 2006Trudell Medical International, Inc.Dose indicating device
US710798619 Jun 200319 Sep 2006Glaxo Group LimitedDispenser with doses' counter
US71471705 Sep 200312 Dic 2006Philip Morris Usa Inc.Aerosol generating device and method of use thereof
US71677762 Sep 200423 Ene 2007Philip Morris Usa Inc.Method and system for controlling a vapor generator
US719191822 Feb 200220 Mar 2007Bespak PlcDosage counting devices
US719513422 Feb 200227 Mar 2007Bespak PlcDosage counting devices
US721966428 Abr 200522 May 2007Kos Life Sciences, Inc.Breath actuated inhaler
US72258055 Dic 20015 Jun 2007Clinical Designs LimitedDrug dispenser
US72344604 Sep 200326 Jun 20073M Innovative Properties CompanyMetering valve for a metered dose inhaler providing consistent delivery
US723772713 Abr 20063 Jul 2007Hsing-Tzu WangPaint spray gun
US727012416 Mar 200118 Sep 2007Astrazeneca AbInhaler
US727566015 Jul 20032 Oct 2007Valois SasDose indicator for fluid product dispensing device
US729656715 Sep 200320 Nov 20073M Innovative Properties CompanyBreath actuated aerosol dispensers
US729980023 Dic 200227 Nov 2007Valois S.A.S.Fluid product dispensing device
US72998014 Sep 200327 Nov 20073M Innovative Properties CompanyMetering valve for a metered dose inhaler providing consistent delivery
US730611625 Nov 200211 Dic 2007Ing. Erich Pfeiffer GmbhDosing device
US731843417 Feb 200515 Ene 2008Microdose Technologies, Inc.Synthetic jet based medicament delivery method and apparatus
US732235218 Sep 200329 Ene 2008Aventis Pharma LimitedInhaler
US73313404 Mar 200419 Feb 2008Ivax CorporationMedicament dispensing device with a display indicative of the state of an internal medicament reservoir
US73345771 Mar 200626 Feb 2008Microdose Technologies, Inc.Synthetic jet based medicament delivery method and apparatus
US734105729 Nov 200511 Mar 2008Trudell Medical InternationalIndicating device
US734720019 Oct 200125 Mar 2008Smithkline Beecham CorporationMedicament dispenser
US734720223 Ago 200425 Mar 2008Shl Medical AbInhaler
US73673333 Nov 20036 May 2008AstraZeneċa ABInhalation device
US73871212 Jul 200117 Jun 2008Smithkline Beechem CorporationValve for aerosol container
US740094021 Jun 200415 Jul 2008Philip Morris Usa Inc.Method and apparatus for generating a volatilized liquid
US741896110 Feb 20042 Sep 2008Bespak PlcDispensing apparatus
US744834210 May 200711 Nov 2008Alfred Von SchuckmannStep-action indexing mechanism
US745426730 Jun 200618 Nov 2008Glaxo Group LimitedMedicament dispenser
US749721413 Ago 20033 Mar 20093M Innovative Properties CompanyAerosol dispensers and adaptors therefor
US751010027 Jul 200431 Mar 2009Valois S.A.S.Dose indicator for a fluid dispenser device
US75970996 Sep 20076 Oct 2009Glaxo Group LimitedMedicament dispenser
US76372608 Jun 200129 Dic 2009Norton Healthcare LimitedMedicament dispensing device with a multimaterial diaphragm bounding a pneumatic force chamber
US77437653 Feb 200629 Jun 2010Astrazeneca AbInhalation device
US2001001334225 Abr 200116 Ago 2001Astrazeneca AbInhalation device
US2001001334326 Mar 199916 Ago 2001Malin AnderssonInhalation device
US200100256395 Jun 20014 Oct 2001Astrazeneca AbInhaler
US200100326442 Abr 200125 Oct 2001Astra Pharmaceuticals LimitedInhalation device
US200200002259 May 20013 Ene 2002Carlos SchulerLockout mechanism for aerosol drug delivery devices
US2002001124718 Abr 200031 Ene 2002Yehuda IvriMethods and apparatus for storing chemical compounds in a portable inhaler
US2002002693813 Nov 20017 Mar 2002Astra Ab.Inhalation device
US20020043262 *22 Ago 200118 Abr 2002Alan LangfordSpray device
US2002008845813 Mar 200211 Jul 2002Astrazeneca AbInhaler
US2002010047313 Mar 20021 Ago 2002Astrazeneca AbInhaler
US200201045302 Nov 20018 Ago 2002Aerogen, Inc.Piezoelectric polymer flow sensor and methods
US2002010453226 Mar 20028 Ago 2002Astrazeneca AbInhaler
US2002013981226 Oct 20013 Oct 2002Scarrott Peter MycolaIndicating device
US2002018961110 Abr 200219 Dic 2002Greenwood Mark H.Inhalation counter device
US2003003305529 Jul 200213 Feb 2003Mcrae Douglas D.Method and apparatus for generating a volatilized liquid
US20030065149 *18 Abr 20023 Abr 2003Northfield LaboratoriesStabilized hemoglobin solutions
US200300893688 Feb 200115 May 2003Junguo ZhaoActuator nozzle for metered dose inhaler
US200301065502 Jul 200112 Jun 2003Harvey Stephen JamesValve for aerosol container
US2003011615516 Mar 200126 Jun 2003Jorgen RasmussenInhaler
US2003013640116 Mar 200124 Jul 2003Rob JansenInhaler
US200301385593 Feb 200324 Jul 2003Smithkline Beecham CorporationProcess for manufacturing a metered dose inhaler
US2003015044824 Jul 200114 Ago 2003Bacon Raymond JohnDispenser
US2003017802116 Mar 200125 Sep 2003Jorgen RasmussenInhaler
US2003018322516 Mar 20012 Oct 2003Lars KnudsenInhaler
US2003018322611 Jul 20012 Oct 2003Brand Peter JohnMedicament dispenser
US2003019253515 May 200316 Oct 2003Astrazeneca Ab.Inhaler
US2003020705718 Sep 20016 Nov 2003Britto Ignatius LoyMetered dose inhaler can coated two or more times with fluorocarbon polymers
US2003023030519 Jun 200318 Dic 2003Astra Zeneca AbInhaler
US2004000547527 Jun 20038 Ene 2004Curie Kevin JamesTransparent multilayer polypropylene container with barrier protection
US2004002048616 Mar 20015 Feb 2004Huxham Laurence StanmoreInhaler
US200400258678 Jun 200112 Feb 2004Michael HolroydMedicament dispensing device with a multimaterial diaphragm bounding a pneumatic force chamber
US2004002586828 Ago 200112 Feb 2004Pascal BrunaFluid product dispenser
US2004002587024 Sep 200112 Feb 2004Nigel HarrisonDosing device
US200400555965 Dic 200125 Mar 2004Bacon Raymond JohnDrug dispenser
US2004006532024 Ene 20028 Abr 2004Bacon Raymond JohnDispenser
US2004006532620 Dic 20018 Abr 2004Macmichael Donald Bruce AthertonDelivery device
US20040068218 *3 Oct 20028 Abr 20043M Innovative Properties Company Office Of Intellectual Property CounselSkin antiseptic composition dispenser and methods of use
US2004006930124 Ene 200215 Abr 2004Bacon Raymond JohnDispenser for medicament
US2004007936224 Jun 200329 Abr 2004Astrazeneca AbInhaler
US2004008929926 Sep 200113 May 2004Bonney Stanley GeorgeInhaler
US2004010796224 Sep 200110 Jun 2004Nigel HarrisonPressure-responsive means and associated method of manufacture
US200401297935 Sep 20038 Jul 2004Chrysalis Technologies IncorporatedAerosol generating device and method of use thereof
US2004013448813 Feb 200215 Jul 2004Davies Michael BirshaMedicament dispenser
US200401344893 Nov 200315 Jul 2004Astrazeneca AbInhalation device
US20040134824 *11 Mar 200215 Jul 2004Sandra ChanCanisters for use in metered dose inhalers
US200401399654 Sep 200322 Jul 20043M Innovative Properties CompanyMetering valve for a metered dose inhaler providing consistent delivery
US200401399664 Sep 200322 Jul 20043M Innovative Properties CompanyMetering valve for a metered dose inhaler providing consistent delivery
US2004014479822 Feb 200229 Jul 2004Tianhong OuyangDosage counting devices
US2004014977222 Feb 20025 Ago 2004Tianhong OuyangDosage counting devices
US2004014977322 Feb 20025 Ago 2004Tianhong OuyangDosage counting devices
US200401721622 Abr 20022 Sep 2004Bonney Stanley GeorgeMedicament dispenser
US2004018786514 Abr 200430 Sep 2004Smithkline Beecham Corp.Metered dose inhaler for fluticasone propionate
US20040230286 *9 Mar 200418 Nov 2004Moore Scott T.Stent introducer apparatus
US2005001652823 Ago 200427 Ene 2005Shl Medical AbInhaler
US2005007690419 Oct 200114 Abr 2005Anthony Patrick JonesMedicament dispenser
US200500818464 Mar 200421 Abr 2005Brian BarneyMedicament dispensing device with a display indicative of the state of an internal medicament reservoir
US2005008719118 Oct 200428 Abr 2005Robert MortonIndicating device with warning dosage indicator
US2005012102415 Ago 20019 Jun 2005Alan LangfordSpray device
US2005012646916 Jun 200416 Jun 2005Lu Winston Z.Dose indicating device
US2005014386621 Jun 200430 Jun 2005Chrysalis Technologies IncorporatedMethod and apparatus for generating a volatilized liquid
US2005018372417 Feb 200525 Ago 2005Microdose Technologies, Inc.Synthetic jet based medicament delivery method and apparatus
US2005020551224 May 200522 Sep 2005Trudell Medical InternationalIndicating device
US2005020955819 May 200322 Sep 2005Eduard MarxDose indicators and dispensing canister-indicator assemblies
US2005026361226 May 20041 Dic 2005Hsing-Tzu WangPaint spray gun
US2006001119713 Ago 200319 Ene 2006Hodson Peter DAerosol dispensers and adaptors therefor
US2006003761115 Sep 200323 Feb 2006Mahon Gary DBreath actuated aerosol dispensers
US200600473682 Sep 20042 Mar 2006Chrysalis Technologies IncorporatedMethod and system for controlling a vapor generator
US2006006019214 Sep 200523 Mar 2006Lu Winston ZDose indicating device with display elements attached to container
US200600710275 Nov 20036 Abr 2006Davies Michael BContainer
US2006013134618 Jun 200422 Jun 2006Purkins Graham RTwo component molded valve stems
US2006015152419 Ene 200413 Jul 2006Fabio StradellaDosage indicator for a device dispensing a fluid product
US2006016327515 Jul 200327 Jul 2006Fabio StradellaDose indicator for fluid product dispensing device
US200601748691 Mar 200610 Ago 2006Gumaste Anand VSynthetic jet based medicament delivery method and apparatus
US2006018622313 Abr 200624 Ago 2006Hsing-Tzu WangPaint spray gun
US200602135053 Feb 200628 Sep 2006Astrazeneca AbInhalation device
US200602135063 Feb 200628 Sep 2006Astrazeneca AbInhalation device
US200602135103 Feb 200628 Sep 2006Astrazeneca AbInhalation device
US200602310934 Nov 200319 Oct 2006Simon BurgePressurised inhalers
US2006023700230 Jun 200626 Oct 2006Glaxo Group LimitedMedicament Dispenser
US2006023700910 Feb 200426 Oct 2006Jones Matthew MDispensing apparatus
US2006024327528 Abr 20052 Nov 2006Kos Life Sciences, Inc.Breath Actuated Inhaler
US200602545819 May 200616 Nov 2006Perry GenovaDose counting in metered dose inhaler
US2006027822513 Jun 200614 Dic 2006Astrazeneca Ab, A Sodertalje, Sweden CorporationDelivery device
US2006028344410 Feb 200421 Dic 2006Matthew JonesDispensing apparatus
US2006028900510 Feb 200428 Dic 2006Jones Matthew MDispensing Apparatus
US2006028900821 Jul 200628 Dic 2006Rand Paul KDispenser with doses' counter
US2007001751114 May 200425 Ene 2007Hitachi, Ltd.Inhalation type dosing device
US2007002934113 Jul 20048 Feb 2007Valois S.A.S.Dose indicator for fluid product dispensing device
US2007005174514 May 20048 Mar 2007Valois S.A.S.Fluid product dispenser
US2007005650226 Jul 200615 Mar 2007Trudell Medical Internatioal Inc.Dose indicating device
US2007005658010 Feb 200415 Mar 2007Matthew JonesDispensing apparatus
US2007005658521 Sep 200415 Mar 2007Davies Michael BMedicament dispenser
US2007006251824 Ago 200622 Mar 2007Boehringer Ingelheim International GmbhAtomizer
US2007006252220 Feb 200422 Mar 2007Bacon Raymond JDispenser
US2007008973526 Jun 200226 Abr 2007Alan LangfordAerosol actuator
US2007011945024 Sep 200431 May 2007Wharton David PMedication holder
US2007014451422 Dic 200528 Jun 2007Yeates Donovan BAerosol processing and inhalation method and system for high dose rate aerosol drug delivery
US2007016357617 Mar 200319 Jul 2007Bacon Raymond JCan fixture
US2007018112021 Nov 20069 Ago 2007Andrew WrightAerosol dispensing apparatus
US2007018112325 Jun 20049 Ago 2007Houzego Peter JDispensing device
US2007019404127 Jul 200423 Ago 2007Fabio StradellaDose indicator for a fluid dispenser device
US2007021010225 Abr 200513 Sep 2007Giuseppe StradellaIndicator for a Device for Dispensing a Hiquid or Powdery Product
US2007024113613 Jun 200518 Oct 2007Valois S.A.S.Fluid Product Dispenser
US2007024604230 Nov 200425 Oct 20073M Innovative Properties CompanyDose Counter for Dispensers
US2007025195010 Dic 20041 Nov 2007Clinical Designs LimitedDispenser and Counter
US2007028438317 May 200713 Dic 2007Andrew WrightDispensing apparatus
US2008001718922 Feb 200724 Ene 2008Tom RuckdeschelBreath actuated inhaler
US200800171936 Sep 200724 Ene 2008Jones Anthony PMedicament dispenser
US2008003514410 Abr 200614 Feb 2008Astrazeneca AbInhaler Device Counter
US2008004187713 Jul 200421 Feb 2008Fabio StradellaDose Indicator for fluid Product Dispensing Device
US2008004755631 Oct 200728 Feb 20083M Innovative Properties CompanyMetering valve for a metered dose inhaler providing consistent delivery
US2008006064323 Jun 200513 Mar 2008Astrazeneca AbInhaler Device that Reduces the Risk for Miscounting a Dosage
US2008006674223 Jun 200520 Mar 2008Astrazeneca AbInhaler Device Counter
US200800928879 Nov 200524 Abr 2008Hodson Peter DSingle-Dose Inhalation Devices
US200801157846 Dic 200722 May 2008Gumaste Anand VSynthetic jet based medicament delivery method and apparatus
US2008013557523 May 200512 Jun 2008Bespak PlcDispensing Apparatus With Dosage Counter
US2008013557617 Nov 200512 Jun 2008Raymond BaconSubstance Source
US200801733015 Sep 200724 Jul 2008Daniel DeatonVariable dose aerosol drug canister
US2008021022423 May 20064 Sep 2008Shl Group AbDose Counter Device for Inhaler
US2008021022618 Mar 20084 Sep 2008Aventis Pharma LimitedMechanical Doses Counter for a Powder Inhaler
US2008025100425 Abr 200516 Oct 2008Fabio StradellaIndicator for a Powder or Fluid Dispenser Device
US2008028354114 May 200820 Nov 2008Consort Medical PlcDispensing apparatus
US200803143832 Oct 200425 Dic 2008Norton Healthcare Ltd.Dry Powder Inhalation Apparatus
US200901142197 Abr 20067 May 2009Aventis Pharma LtdImprovements in or relating to inhalers
US2009021157831 Jul 200627 Ago 2009Ian FletcherInhaler valve
US200902296047 Sep 200617 Sep 2009Allen John PearsonAn inhaler
US2009022960724 May 200617 Sep 2009Lennart BrunnbergDose Counter
US2009029387026 Feb 20073 Dic 2009Shl Group AbDose Information Device
US200903083851 Mar 200717 Dic 2009Brewer Richard DMethod and apparatus for metered dose dispensing
US2009030838917 Jul 200717 Dic 2009Valois SasFluid-product dispensing device
US201000121158 Sep 200621 Ene 2010Raymond John BaconDispenser
US2010006505015 Oct 200918 Mar 2010Norton Healthcare LimitedMedicament dispensing device with a multimaterial diaphragm bounding a pneumatic force chamber
US20110311138 *20 Abr 201122 Dic 2011Williams Robert CBackground separated images for print and on-line use
US2012001790010 Mar 201026 Ene 2012Euro-Celtique, S.A.Counter
US20120020002 *29 Sep 201126 Ene 2012Mathew Dinesh CPortable computer display structures
AU776816B2 Título no disponible
AU2003234746B2 Título no disponible
AU2003234748B2 Título no disponible
DE4111895C212 Abr 199113 Oct 1994Sigismund LaskowskiVerfahren und Vorrichtung zum Verschließen und Ausgießen von flüssigen Substanzen
DE10061723C212 Dic 200016 Ene 2003Eckert RosemarieZählwerk zum Zählen dosierter Abgaben flüssiger, pastöser oder fester Produkte sowie Einrichtung zum dosierten Abgeben solcher Produkte
DE19745513A115 Oct 199722 Abr 1999Walz Karl HeinzBottle valve system
DE29818662U120 Oct 19982 Mar 2000Wischerath Josef Gmbh Co KgInhalator
EP0428380B113 Nov 199013 Oct 1993Riker Laboratories, Inc.Inhalation device and protective casing
EP0501365A224 Feb 19922 Sep 1992Sigismund LaskowskiMethod and device for dosing of a fluid substance from a supply container
EP0629563A113 Jun 199421 Dic 1994Lilly Industries LimitedDevices for dispensing and counting articles
EP1169245B128 Mar 200030 Ago 2006Bespak plcDispensing apparatus comprising a dosage counting device
EP1201423B112 May 200022 Jun 2005Yoshino Kogyosho Co., Ltd.Layered plastic molding
FR2654627B1 Título no disponible
FR2660630B1 Título no disponible
FR2701653B1 Título no disponible
GB161969A Título no disponible
GB939324A Título no disponible
GB1026763A Título no disponible
GB1270272A Título no disponible
GB2195544A Título no disponible
GB2262452A Título no disponible
GB2263873A Título no disponible
GB2264238A Título no disponible
GB2266466A Título no disponible
GB2278979B Título no disponible
GB2279571A Título no disponible
GB2279879B Título no disponible
GB2292891A Título no disponible
GB2348928B Título no disponible
GB2366519B Título no disponible
GB2372542B Título no disponible
GB2372543B Título no disponible
GB2381201B Título no disponible
GB2385640B Título no disponible
GB2398250A Título no disponible
GB2398251A Título no disponible
GB2429166A Título no disponible
JP63251880A Título no disponible
WO1997030743A213 Feb 199728 Ago 1997Schering CorporationPowdered medication inhaler
WO2001034231A110 Nov 199917 May 2001Innovative Devices, L.L.C.INHALATION ACTUATED DEVICE FOR USE WITH METERED DOSE INHALERS (MDIs)
WO2003035155A122 Oct 20021 May 2003Iep Pharmaceutical Devices Inc.An inhalation actuated device
Otras citas
Referencia
1"Polyethylene-linear low density (LLDPE) CAS No. 9002-88-4" http://www.icis.com/v2/chemicals/9076159/polyethylene-linear.low.density.html. (Jan. 19, 2011).
2"Polyethylene—linear low density (LLDPE) CAS No. 9002-88-4" http://www.icis.com/v2/chemicals/9076159/polyethylene-linear.low.density.html. (Jan. 19, 2011).
3 *Definition of "mouth"; http://www.merriam-webster.com/dictionary/mouth; 2011.
4International Search Report for PCT/GB201 0/050405, mailed Jun. 16, 2010.
5Japanese Office Action dated Sep. 24, 2010, issued in corresponding Japanese Application No. 2007-547614 (in English )-6 pages.
6Japanese Office Action dated Sep. 24, 2010, issued in corresponding Japanese Application No. 2007-547614 (in English )—6 pages.
7 *Machine Translation of Claim 1 of DE 1077932 (Date Unavailable).
8 *Machine Translation of Claim 1 of DE 202004021188 U (Date Unavailable).
9 *Machine Translation of Claim 1 of DE 629163 (Date Unavailable).
10 *Machine Translation of Claim 1 of DE 8715223 U (Date Unavailable).
11Rejection Decision dated Feb. 25, 2011, from copending Japanese Application No. 2007-547614, citing JP 57-75855 and JP 56-155759 (one page).
12Rejection Decision from copending Japanese Application citing JP 57-75855 and JP 56-155759 (one page).
13U.S. Appl. No. 13/138,591, filed Jan. 2012, Bacon et al.
14Written Opinion of the International Searching Authority for PCT/GB2010/050405 mailed Jun. 16, 2010.
Citada por
Patente citante Fecha de presentación Fecha de publicación Solicitante Título
US957294531 Oct 201221 Feb 2017Euro-Celtique S.A.Dispenser
Eventos legales
FechaCódigoEventoDescripción
11 Jun 2007ASAssignment
Owner name: CLINICAL DESIGNS LIMITED, GREAT BRITAIN
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:BACON, RAYMOND;REEL/FRAME:019460/0478
Effective date: 20070608
13 Nov 2012ASAssignment
Owner name: CLINICAL DESIGNS LIMITED, UNITED KINGDOM
Free format text: CHANGE OF ADDRESS;ASSIGNOR:CLINICAL DESIGNS LIMITED;REEL/FRAME:029481/0565
Effective date: 20111231
1 Jun 2016FPAYFee payment
Year of fee payment: 4