US9180028B2 - Structural hydrogel polymer device - Google Patents
Structural hydrogel polymer device Download PDFInfo
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- US9180028B2 US9180028B2 US13/231,752 US201113231752A US9180028B2 US 9180028 B2 US9180028 B2 US 9180028B2 US 201113231752 A US201113231752 A US 201113231752A US 9180028 B2 US9180028 B2 US 9180028B2
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- stent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/844—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents folded prior to deployment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
- A61L29/041—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/145—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/145—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0017—Catheters; Hollow probes specially adapted for long-term hygiene care, e.g. urethral or indwelling catheters to prevent infections
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2207/00—Methods of manufacture, assembly or production
Abstract
The present invention relates generally a manufacturing process which results in a completely hydrogel polymer device that maintains lumen patency which allows for numerous applications. Catheters and stents are particular examples, and their composition, mechanical characteristics, and the significantly unique ability to conduct and allow fluids to pass from one end to the other without physiological rejection, inflammation, or manifestation of complications due to implant or otherwise undesirable outcomes when used for ambulatory and or therapeutic interventions is the purpose of the invention.
Description
This application claims the benefit of U.S. Provisional Application No. 60/78731,740 filed on Oct. 31, 2005, the contents of which are incorporated herein by reference.
The present invention relates generally to a manufacturing process and a resulting apparatus which results in a completely hydrogel polymer device that maintains lumen patency which allows for numerous applications, particularly, catheters and stents.
Generally, the common approaches utilized in the art to fabricate a product from hydrolyzed PAN entail typically coagulating a single layer or heavily plasticizing a solvent based formula hydrolyzed PAN, in order that it may be molded or extruded by conventional thermoplastic extrusion or injection molding methods. Unfortunately, do to limitations, these materials and related processes are not reliable and often lead to inconsistencies in production and/or components.
As referenced in U.S. Pat. No. 6,232,406 and in fact improvements so noted in U.S. Pat. No. 4,943,618 are probably not necessary when manufacturing a product with the disclosed process. Many types of devices are available and generally well known in the art of catheter design and construction which exhibit various curved and coiled end geometrical configurations for anchorage while others rely on material and polymer characteristics to increase performance and patient comfort. It is also generally known that some devices can be particularly difficult to implant, and withdraw. Unfortunately these designs do not minimize migrations and their lubricous coatings, which will erode off, do not diminish patient comfort, and encrustation.
In a typical modality, conventional thermoplastic polyurethane Ureteral Stent or Catheter is likely to migrate due to physiological or peristaltic organ and or muscle movement. Thereafter the device may become dislodged from its location rendering it ineffective. Additionally, after a relatively short period of time urine salts for example typically adhere to the coated and uncoated devices diminishing flow, and comfort, increasing patient pain and jeopardizing device integrity. The disclosed invention will alleviate these unacceptable complications.
It is the object of the invention to provide a stent or catheter fabricated in a manner totally comprised of a hydrogel capable of becoming structural in its final configuration having a cross sectional area that increases with hydration, while maintaining mechanical integrity.
It is a further object of the invention to provide a catheter or stent that incorporates a manufacturing process that results in an end product that is stable, will not erode and will exhibit tensile strengths and elongations that allow use in applications where typical thermoplastic devices are currently used. Said devices immediately exhibit lubricous surface characteristics when wetted with any aqueous media and provide increased resistance to biological complications once implanted. Substantial mechanical characteristics are exhibited by a fully hydrated device, which can be loaded with colorants, radiopacifiers and fillers.
The present invention relates generally to the field of catheters used to maintain flow in the urinary system for example and in particular a configuration that maintains an atraumatic passage where the structural hydrogel composition provides comfort, placement and mechanical advantage. Hydrolyzed polyacrylicnitrile (PAN) polymers produced utilizing the present method result in a superior end product when produced with the disclosed process. Use of this method overcomes inconstancies in present formulations and devices made in accordance with the instant process yield a 100% hydrogel composition stent, catheter or hybrid version which may can be implanted with a substantially smaller diameter and then hydrated into a predictable larger, softer size within a controllable period of time. The catheter or hybrid will also be relatively rigid for ease of placement and track-ability.
The present invention relates generally a manufacturing process which results in a completely hydrogel polymer device that maintains lumen patency which allows for numerous applications. Catheters and stems are particular examples, and their composition, mechanical characteristics, and the significantly unique ability to conduct and allow fluids to pass from one end to the other without physiological rejection, inflammation, or manifestation of complications due to implant or otherwise undesirable outcomes when used for ambulatory and or therapeutic interventions is the purpose of the invention.
Accordingly, a ureteral stent is provided having anchorage that will not migrate, exhibits resistance to encrustation and facilitates ease of implant and withdrawal. In general, the placement of the structural hydrogel, ureteral stent or catheter creates in a path from which fluids can be reliably conducted from one end to the other, which requires no significant clinical follow up due to device migration, encrustation or related patient comfort issues.
Advantages of the present invention will be apparent from the following detailed description of exemplary embodiments thereof, which description should be considered in conjunction with the accompanying drawings, in which:
A Stent or catheter or composite of the structural hydrogel and a metal, plastic or other component, and process for producing the same is illustrated herein. The finished device as disclosed is comprised of 100% Hydrogel polymer which is stable and structural in its final composition, not requiring a substrate or scaffold to maintain composition or mechanical characteristics.
Referring now to the drawings, particularly in FIG. 1 , there is generally indicated the stent of the present invention. As illustrated in FIG. 1 , the body of the stent 1 is displayed, along with the uretral lumen 3 and the outward radial forces 2. The trumpet or barbell distal end for anchorage with radiopacifier fill 4 is also shown. In FIG. 2 , the path urine travels through the body is shown. How the urine 5 will flow from the kidney, 6 through the anchorage in the kidney, 8 through the ureter, 7 through the anchorage of the ureter 9 and into the bladder 10. The urine will then flow 12 through the urethra 11.
The potential inflation of the outer layer 67 of the catheter shaft 66 of a low profile integral balloon 68 is displayed. FIG. 7E shows a more detailed side view of the potential expansion for drug refilling purposes. The optional inflation 69 with a thin wall of the balloon 70 with an optional drug reservoir 72 is shown more clearly. FIG. 7F shows an end view of what the catheter or stent will look like when expanded. The increased diameter of the stent 71 with the force that is exerted outwards by the fluid flowing through 73 is displayed. FIG. 7G shows what the ends of the devices will look like if expanded. A solid core 74 with multiple layers of radiopaque filled hydrogel forming a tip 75 with the layers required by the process 76. A potential adhesive 77 could also be implemented. FIG. 8A shows three potential configurations of A 78, B, 79 and C 80.
These configurations depict different potential forces that may be applied depending on the volume and amount of flow of liquid through the device. FIG. 8B shows how drugs may be delivered through diffusion 81 if that option is pursued. FIG. 9A shows an interior cross sectional view of the final device while FIG. 9B shows what the outside of the final device will look like.
In the preferred embodiment, a Physician skilled in the ability can be expected to implant and retrieve a Structural Hydrogel Device in the same manner as a thermoplastic device. A Structural Hydrogel Ureteral Stent or catheter can be implanted transuretheraly or percutaneously from the kidney into the Ureter considerably smaller in diameter and once wetted immediately lubricous while hydrating, and increasing in corresponding volume.
This instant process ideally can be used to fabricate an entity, device or product which exhibits a reversible function, ideally infinitely where the material can be dehydrated and re-hydrated as required. In that sense, the primary mechanism of the process is that the first or inner layer material is deposited fully hydrated and then subsequently dehydrated as a part of the process, see step (1) FIG. 3 , FIGS. 4A & B. Then a sequential layer is added whereby the solvent in the second layer solution that allows the hydrogel to be in a semi-liquid phase will interact with the dehydrated first or inner layer beneath and a covalent interface will be achieved, see step (2) FIG. 3 , FIGS. 4A & B. This material defined as a hydrogel, is in its semi-fluid phase before solidification, and used as a raw material in the disclosed process. Furthermore different concentrations of solids or fillers in the hydrogel material can be deposited by for example controlling several reservoirs flowing into one manifold with one unique outlet, see FIGS. 4C & D.
Additionally, mandrels used for initial processing, may be removed to create additional effects. For example a larger OD mandrel will result in a thinner dehydrated wall when preparing for a concurrent layer. Similarly, a smaller OD mandrel, no mandrel or a combination of diameters could be used for additional desired effects, see FIGS. 5A & B.
Conversely, the disclosed (reversible dehydration/hydration lamination) process provides a novel advantageous alternative when designing or fabricating products made from raw materials such as hydrolyzed PAN type materials that need to exhibit excellent mechanical characteristics while maintaining low percent solids, see FIG. 6 .
One of the most valuable attributes of the disclosed process allows processing from solvent-based hydrogel solutions that result in a structural hydrogel device exceeding the performance of coagulated hydrolyzed PAN products and components. Therefore the disclosed process exceeds the limitation of materials such as hydrolyzed PAN but also includes any formulation that exhibits a reversible function whereby the material can be dehydrated and re-hydrated. In that manner, the disclosed process allows the layering and or lamination of layers in accordance with the disclosed process resulting in a laminated structural hydrogel of predominately low solids and high corresponding aqueous content that will exhibit significant mechanical characteristics such that a stable product can be produced. Subsequently, this novel process allows the lamination of subsequent concurrent layers that in a final configuration provide the enhanced mechanical characteristics that result in 100% structural hydrogel products as well as hybrid versions, see FIGS. 7A , B, C, D, E, F & G.
Although one primary advantage of the disclosed process is the ability to adhere one hydrogel layer to another hydrogel layer or other surface material, and that the lamination of such layers together results in and benefit from the compression of the outer layers or at least the integration of the outer layer to the associated inner layer; one can incorporate or produce a hybrid by for example incorporating a braid or fabric between layers, see FIG. 7A .
Therefore the disclosed process results in the revolutionary never before claim of adhering one hydrogel layer to another hydrogel layer, which as disclosed is the primary influence resulting in the superior mechanical and biocompatibility performance characteristics of the as called structural hydrogel product or device.
A hybrid device for example utilizing a structural hydrogel distal tip manufactured in accordance with the disclosed process, and adhered to or processed directly onto a conventional metal, TPE/TPU device surface, such as for example a catheter where the hydrogel is not a coating but an integral component, see FIGS. 7B & C could diminish complications related to implantation.
Furthermore, a hybrid device utilizing a structural hydrogel design manufactured in accordance with the disclosed process can be engineered with different percent concentrations of solids in a specific layer, or segmented or positioned specifically along the axis of a catheter shaft for example. In this manner radiopaque media can be placed where it is desired, or a denser matrix can be produced in specific layers or segment along the axis, providing a differential gradient that would promote diffusion or conduction enhancing drainage, or providing a specific drug delivery barrier, see FIGS. 8A & B.
Otherwise, current processing of hydrolyzed PAN and alike hydrogels is limited to only primarily coagulation of freely poured or molded gel, typically into a sheet form where further processed including secondary operations that include many methods of cross-lonking such as exposure to radiation, freeze/thaw methods, and modifications to the polymer chemistry, as well as using hot acid to enhance its hydrophylicity and or primers that are required to attach coatings to an intended substrate.
This dangerous, expensive and marginally successful operation is not required with the disclosed process which produces a low solids and therefore correspondingly highly hydrophilic product.
Thermoplastic extrusion processes are possible with many hydrogel formulae, in order to make them perform like conventional TPE and TPU's. Although thermoplastic extrusion typically results in components and products that exhibit adequate mechanical characteristics, thermoplastic extrusion of for example hydrolyzed PAN does not yield a component or product that exhibits a large aqueous content compared to product manufactured from the disclosed process. Furthermore, for example extruding hydrolyzed PAN requires loading the polymer resin with large amounts of plasticizers, and when radiopacifers are added the end product contains a much higher percent of solid than exhibited by products manufactured with the disclosed process, diminishing the hydrophilicity, and bio-compatibility.
The advantages therefore are that the disclosed process which doesn't require thermoplastic processing (although it can be extruded or molded); doesn't require post processing to enhance hydrophylicity, and isn't sensitive to variations in the base polymer chemistry can be used to cost effectively derive products which will exhibit a much higher level of aqueous absorption and related bio-compatibility which is paramount and related while exhibiting the required mechanical characteristics, which if not achieved, the device or product application wouldn't be possible.
To achieve this bio-compatibility and in accordance with the benefits of the disclosed process a catheter for example might be produced with several layers whereby the last layer is void of but all previous layers would be filled with radiopacifiers, see FIG. 9 . In this manner human tissue does not come into contact with the radiopaque filler medias as would devices produced of or conventional hydrogels, TPE or TPU's.
Also drug delivery systems and attempts to force the change in volume resulting in for example predetermined radial forces can be exhibited by adding or not adding fillers or generally the specification of the percent of hydrogel solids in a given layer or layers as illustrated in FIG. 8 .
Claims (19)
1. A stent or catheter comprising:
a first layer including a coagulated hydrogel polymer material defining a lumen of the stent or catheter; and
a second layer encircling the first layer, the second layer including a coagulated hydrogel polymer material fused with the underlying coagulated hydrogel polymer material of the first layer at an interface; the interface having a structural configuration corresponding to the hydrogel polymer material of the second layer in a solvated state fused to the coagulated hydrogel polymer material of the first layer in a dehydrated state;
wherein the hydrogel polymer material of the second layer is configured to at least partially constrain radial expansion of the hydrogel polymer material of the first layer upon hydration of the device thereby achieving compression of the first layer; and
wherein, upon hydration, most of the structural integrity of the stent or catheter is provided by the structure of the coagulated hydrogel polymer material layers.
2. The stent or catheter of claim 1 , further comprising one or more additional layers encircling the second layer, each additional layer comprising a hydrogel polymer material fused with a coagulated hydrogel polymer material of an underlying layer.
3. The stent or catheter of claim 2 , wherein each of the second layer and the one or more additional layers is configured to at least partially constrain radial expansion of a hydrogel polymer material of an underlying layer when the device is in a hydrated state.
4. The stent or catheter of claim 1 , wherein the stent or catheter is configured to maintain patency of an anatomical lumen during use.
5. The stent or catheter of claim 1 , wherein, when hydrated, substantially all of the structural integrity of the stent or catheter is provided by the hydrogel polymer materials.
6. The stent or catheter of claim 1 , wherein the stent or catheter is configured to expand to have a predictable outer diameter and a predictable inner diameter upon hydration.
7. The stent or catheter of claim 6 , wherein the stent or catheter in a dehydrated state is configured to expand within a controlled amount of time upon hydration.
8. The stent or catheter of claim 1 , wherein the hydrogel polymer materials of the stent or catheter resist biological infestation during use.
9. The stent or catheter of claim 1 , wherein the stent or catheter is configured for absorbing peristaltic forces to reduce the likelihood of migration when the device is in a hydrated state.
10. The stent or catheter of claim 1 , wherein the stent or catheter is configured to withstand dehydration and rehydration without degradation of mechanical properties of the device.
11. The stent or catheter of claim 1 , wherein the coagulated hydrogel polymer material of the first layer forms a lubricious surface of the lumen when the device is in a hydrated state.
12. The stent or catheter of claim 1 , wherein a hydrogel polymer material of an outermost layer of the stent or catheter forms a lubricious outer surface when the device is in a hydrated state.
13. The stent or catheter of claim 1 , wherein the hydrogel polymer material of the first layer and a hydrogel polymer material of an outermost layer of the stent or catheter exhibit lubricious surface properties immediately upon wetting.
14. The stent or catheter of claim 1 , wherein the hydrogel polymer material of the first layer and the hydrogel polymer material of the second layer comprise a same type of polymer.
15. The stent or catheter of claim 14 , wherein the hydrogel polymer material of the first layer has a different composition than a hydrogel polymer material of the second layer.
16. The stent or catheter of claim 1 , wherein at least one of the first layer or the second layer includes multiple portions, each portion including a hydrogel polymer material having physical and/or chemical properties different than those of a hydrogel polymer material of an adjacent portion.
17. The stent or catheter of claim 1 , wherein the hydrogel polymer material of the first layer comprises a hydrolyzed polyacrylonitrile polymer and wherein the hydrogel polymer material of the second layer comprises a hydrolyzed polyacrylonitrile polymer.
18. The stent or catheter of claim 1 , wherein the stent or catheter includes at least a portion of a layer configured as a reservoir for a liquid.
19. The stent or catheter of claim 1 , wherein an outermost layer of the stent or catheter includes an inflatable portion.
Priority Applications (4)
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US13/231,752 US9180028B2 (en) | 2005-10-31 | 2011-09-13 | Structural hydrogel polymer device |
US14/881,753 US10881537B2 (en) | 2005-10-31 | 2015-10-13 | Structural hydrogel polymer device |
US17/132,493 US11896505B2 (en) | 2005-10-31 | 2020-12-23 | Methods for making and using a structural hydrogel polymer device |
US18/524,495 US20240091033A1 (en) | 2005-10-31 | 2023-11-30 | Methods for Making and Using a Structural Hydrogel Polymer Device |
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US11/590,219 US8048350B2 (en) | 2005-10-31 | 2006-10-31 | Structural hydrogel polymer device |
US13/231,752 US9180028B2 (en) | 2005-10-31 | 2011-09-13 | Structural hydrogel polymer device |
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US14/881,753 Active 2029-11-11 US10881537B2 (en) | 2005-10-31 | 2015-10-13 | Structural hydrogel polymer device |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10751206B2 (en) | 2010-06-26 | 2020-08-25 | Scott M. Epstein | Catheter or stent delivery system |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60135455D1 (en) | 2000-05-16 | 2008-10-02 | Univ Minnesota | IT OF MULTI-NOZZLE ARRANGEMENT |
US8999364B2 (en) | 2004-06-15 | 2015-04-07 | Nanyang Technological University | Implantable article, method of forming same and method for reducing thrombogenicity |
US8048350B2 (en) | 2005-10-31 | 2011-11-01 | Scott Epstein | Structural hydrogel polymer device |
EP2529761B1 (en) * | 2006-01-31 | 2017-06-14 | Nanocopoeia, Inc. | Nanoparticle coating of surfaces |
CA2637883C (en) | 2006-01-31 | 2015-07-07 | Regents Of The University Of Minnesota | Electrospray coating of objects |
US9108217B2 (en) | 2006-01-31 | 2015-08-18 | Nanocopoeia, Inc. | Nanoparticle coating of surfaces |
US8206636B2 (en) * | 2008-06-20 | 2012-06-26 | Amaranth Medical Pte. | Stent fabrication via tubular casting processes |
US10898620B2 (en) | 2008-06-20 | 2021-01-26 | Razmodics Llc | Composite stent having multi-axial flexibility and method of manufacture thereof |
US8206635B2 (en) | 2008-06-20 | 2012-06-26 | Amaranth Medical Pte. | Stent fabrication via tubular casting processes |
US20110319902A1 (en) * | 2010-06-26 | 2011-12-29 | Scott Epstein | Catheter delivery system |
US20150352014A1 (en) * | 2013-01-07 | 2015-12-10 | Gi Dynamics, Inc. | Jejunal Feeding Tube And Delivery System |
WO2016168505A1 (en) * | 2015-04-16 | 2016-10-20 | Stryker Corporation | System and method for manufacturing variable stiffness catheters |
JP7261160B2 (en) * | 2016-11-23 | 2023-04-19 | ホロジック, インコーポレイテッド | biopsy site marker |
Citations (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3862452A (en) * | 1966-05-04 | 1975-01-28 | Ceskoslovenska Akademie Ved | Hydrogel substitutes for tubular somatic organs |
US3890683A (en) * | 1972-12-22 | 1975-06-24 | Ceskoslovenska Akademie Ved | Roller with an elastic hydrogel layer for dye application or printing on glass and other materials |
US4026296A (en) | 1974-03-19 | 1977-05-31 | Ceskoslovenska Akademie Ved | Hydrophilic surgical tubular device |
US4183884A (en) * | 1973-01-24 | 1980-01-15 | Ceskoslovenska Akademie Ved | Method for manufacturing hydrogel tubes |
US4475972A (en) | 1981-10-01 | 1984-10-09 | Ontario Research Foundation | Implantable material |
US4762128A (en) | 1986-12-09 | 1988-08-09 | Advanced Surgical Intervention, Inc. | Method and apparatus for treating hypertrophy of the prostate gland |
US4943618A (en) | 1987-12-18 | 1990-07-24 | Kingston Technologies Limited Partnership | Method for preparing polyacrylonitrile copolymers by heterogeneous reaction of polyacrylonitrile aquagel |
US5149052A (en) | 1987-11-16 | 1992-09-22 | Kingston Technologies, Inc. | Precision molding of polymers |
US5601881A (en) | 1993-07-30 | 1997-02-11 | Bayer Aktiengesellschaft | Method and device for coating a body rotating about an axis |
US6039694A (en) | 1998-06-25 | 2000-03-21 | Sonotech, Inc. | Coupling sheath for ultrasound transducers |
WO2000018446A1 (en) | 1998-09-25 | 2000-04-06 | Cathnet-Science S.A. | Multi-layered sleeve for intravascular expandable device |
US6200257B1 (en) * | 1999-03-24 | 2001-03-13 | Proxima Therapeutics, Inc. | Catheter with permeable hydrogel membrane |
US6368356B1 (en) * | 1996-07-11 | 2002-04-09 | Scimed Life Systems, Inc. | Medical devices comprising hydrogel polymers having improved mechanical properties |
US20020143385A1 (en) * | 2000-03-13 | 2002-10-03 | Jun Yang | Stent having cover with drug delivery capability |
US6488802B1 (en) | 1998-09-30 | 2002-12-03 | Jerry C. Levingston | Pipe extrusion process |
US20030021762A1 (en) | 2001-06-26 | 2003-01-30 | Luthra Ajay K. | Polysaccharide biomaterials and methods of use thereof |
US6547908B2 (en) | 2001-07-30 | 2003-04-15 | Thermacor Process, Inc. | Method of manufacturing a thermoplastic tubular jacket |
US20030211130A1 (en) | 2002-02-22 | 2003-11-13 | Sanders Joan E. | Bioengineered tissue substitutes |
US20030222369A1 (en) | 2002-05-31 | 2003-12-04 | Nicora Scott W. | Apparatus and method of extruding tubing having a variable wall thickness |
US20050159704A1 (en) * | 2001-11-29 | 2005-07-21 | Neal Scott | High concentration medicament and polymer coated device for passive diffusional medicament delivery |
US20060052478A1 (en) * | 2002-10-02 | 2006-03-09 | Flemming Madsen | Hydrogel |
US8048350B2 (en) | 2005-10-31 | 2011-11-01 | Scott Epstein | Structural hydrogel polymer device |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6060534A (en) * | 1996-07-11 | 2000-05-09 | Scimed Life Systems, Inc. | Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties |
US6419624B1 (en) * | 1999-10-11 | 2002-07-16 | Uromedica, Inc. | Apparatus and method for inserting an adjustable implantable genitourinary device |
-
2006
- 2006-10-31 US US11/590,219 patent/US8048350B2/en active Active
-
2011
- 2011-09-13 US US13/231,752 patent/US9180028B2/en active Active
-
2015
- 2015-10-13 US US14/881,753 patent/US10881537B2/en active Active
Patent Citations (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3862452A (en) * | 1966-05-04 | 1975-01-28 | Ceskoslovenska Akademie Ved | Hydrogel substitutes for tubular somatic organs |
US3890683A (en) * | 1972-12-22 | 1975-06-24 | Ceskoslovenska Akademie Ved | Roller with an elastic hydrogel layer for dye application or printing on glass and other materials |
US4183884A (en) * | 1973-01-24 | 1980-01-15 | Ceskoslovenska Akademie Ved | Method for manufacturing hydrogel tubes |
US4026296A (en) | 1974-03-19 | 1977-05-31 | Ceskoslovenska Akademie Ved | Hydrophilic surgical tubular device |
US4475972A (en) | 1981-10-01 | 1984-10-09 | Ontario Research Foundation | Implantable material |
US4762128A (en) | 1986-12-09 | 1988-08-09 | Advanced Surgical Intervention, Inc. | Method and apparatus for treating hypertrophy of the prostate gland |
US5149052A (en) | 1987-11-16 | 1992-09-22 | Kingston Technologies, Inc. | Precision molding of polymers |
US4943618A (en) | 1987-12-18 | 1990-07-24 | Kingston Technologies Limited Partnership | Method for preparing polyacrylonitrile copolymers by heterogeneous reaction of polyacrylonitrile aquagel |
US5601881A (en) | 1993-07-30 | 1997-02-11 | Bayer Aktiengesellschaft | Method and device for coating a body rotating about an axis |
US6368356B1 (en) * | 1996-07-11 | 2002-04-09 | Scimed Life Systems, Inc. | Medical devices comprising hydrogel polymers having improved mechanical properties |
US6039694A (en) | 1998-06-25 | 2000-03-21 | Sonotech, Inc. | Coupling sheath for ultrasound transducers |
WO2000018446A1 (en) | 1998-09-25 | 2000-04-06 | Cathnet-Science S.A. | Multi-layered sleeve for intravascular expandable device |
US6488802B1 (en) | 1998-09-30 | 2002-12-03 | Jerry C. Levingston | Pipe extrusion process |
US6200257B1 (en) * | 1999-03-24 | 2001-03-13 | Proxima Therapeutics, Inc. | Catheter with permeable hydrogel membrane |
US20020143385A1 (en) * | 2000-03-13 | 2002-10-03 | Jun Yang | Stent having cover with drug delivery capability |
US20030021762A1 (en) | 2001-06-26 | 2003-01-30 | Luthra Ajay K. | Polysaccharide biomaterials and methods of use thereof |
US6547908B2 (en) | 2001-07-30 | 2003-04-15 | Thermacor Process, Inc. | Method of manufacturing a thermoplastic tubular jacket |
US20050159704A1 (en) * | 2001-11-29 | 2005-07-21 | Neal Scott | High concentration medicament and polymer coated device for passive diffusional medicament delivery |
US20030211130A1 (en) | 2002-02-22 | 2003-11-13 | Sanders Joan E. | Bioengineered tissue substitutes |
US20030222369A1 (en) | 2002-05-31 | 2003-12-04 | Nicora Scott W. | Apparatus and method of extruding tubing having a variable wall thickness |
US20060052478A1 (en) * | 2002-10-02 | 2006-03-09 | Flemming Madsen | Hydrogel |
US8048350B2 (en) | 2005-10-31 | 2011-11-01 | Scott Epstein | Structural hydrogel polymer device |
Non-Patent Citations (1)
Title |
---|
W.K. Wan, G. Campbell, Z.F. Zhang, A.J. Hui, D.R. Boughner, "Optimizing the Tensile properties of Polyvinyl Alcohol Hydrogel for the Construction of a Bioprosthetic Heart Valve Stent", J Biomed Mater Res (Appl Biomater) 2002, 63, 854-861. * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10751206B2 (en) | 2010-06-26 | 2020-08-25 | Scott M. Epstein | Catheter or stent delivery system |
Also Published As
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US20070106361A1 (en) | 2007-05-10 |
US20160166412A1 (en) | 2016-06-16 |
US20120178874A1 (en) | 2012-07-12 |
US10881537B2 (en) | 2021-01-05 |
US8048350B2 (en) | 2011-11-01 |
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