Búsqueda Imágenes Maps Play YouTube Noticias Gmail Drive Más »
Iniciar sesión
Usuarios de lectores de pantalla: deben hacer clic en este enlace para utilizar el modo de accesibilidad. Este modo tiene las mismas funciones esenciales pero funciona mejor con el lector.

Patentes

  1. Búsqueda avanzada de patentes
Número de publicaciónUS9220604 B2
Tipo de publicaciónConcesión
Número de solicitudUS 13/333,065
Fecha de publicación29 Dic 2015
Fecha de presentación21 Dic 2011
Fecha de prioridad21 Dic 2010
También publicado comoEP2654626A2, EP2654626B1, US20120179259, US20160089249, WO2012088238A2, WO2012088238A3
Número de publicación13333065, 333065, US 9220604 B2, US 9220604B2, US-B2-9220604, US9220604 B2, US9220604B2
InventoresWilliam P. McDonough, William L. Strausbaugh, Benjamin Chronister, Thomas Pepe, Michael Coover, Katharine Coffman, Thomas Kueenzi, Edwin Chan, Peyman Pakzaban, Kurt Schmura
Cesionario originalDePuy Synthes Products, Inc.
Exportar citaBiBTeX, EndNote, RefMan
Enlaces externos: USPTO, Cesión de USPTO, Espacenet
Intervertebral implants, systems, and methods of use
US 9220604 B2
Resumen
An intervertebral implant frame that is configured to be attached to a spacer body can include a pair of arms that extend longitudinally from a support member such that the arms extend substantially around the spacer body. The arms may be configured to expand, crimp, or otherwise engage the spacer body to thereby hold the spacer body to the frame. The spacer body may be made from bone graft.
Imágenes(26)
Previous page
Next page
Reclamaciones(47)
What is claimed:
1. An intervertebral implant frame comprising:
a support member that defines an inner surface and an outer surface opposite the inner surface, and at least two fixation element receiving apertures that each extend along a respective central axis, each of the fixation element receiving apertures configured to receive a respective bone fixation element to thereby attach the intervertebral implant frame to first and second vertebral bodies, respectively when the intervertebral implant frame is disposed in an intervertebral space defined by first and second surfaces of the first and second vertebral bodies, respectively;
a first arm that extends from the support member and includes a first inner spacer contacting surface, the first arm defining a first terminal end; and
a second arm that extends from the support member and includes a second inner spacer contacting surface spaced from the first inner spacer contacting surface along a first direction, the second arm further including a first vertebral body contacting surface and a second vertebral body contacting surface spaced from the first vertebral contacting along a second direction, the second arm defining a second terminal end, each of the first and second outer terminal ends spaced from the support member along a third direction that is substantially perpendicular to the to both the first direction and the second direction so as to define a first length and a second length, respectively, the first and second lengths each sized to be greater than a third length measured from an anterior end of the first vertebral body to a centroid of the first vertebral body;
wherein 1) the first and second inner spacer contacting surfaces define at least first and second respective contact locations, and at least one of the first and second arms is flexible so as to be movable between a first position, whereby the frame defines a first distance between the first and second contact locations along the first direction, and a second position, whereby the frame defines a second distance between the first and second contact locations along the first direction, the second distance greater than the first distance, such that when in the second position, the at least one of the first and second arms is biased toward the first position, and 2) the central axis of at least one of the at least two fixation element receiving apertures exits the outer surface of the support member at a location between the first and second vertebral body contacting surfaces with respect to the second direction.
2. The intervertebral implant frame of claim 1, wherein the first and second lengths are each between about 3.5 mm and about 12 mm.
3. The intervertebral implant frame of claim 2, wherein the first and second lengths are each between about 6.0 mm and about 10 mm.
4. The intervertebral implant frame of claim 1, wherein the first and second lengths each define a value, respectively, such that the support member, the first arm, and the second arm collectively extend around at least 51% but no more than 99% of a perimeter of a spacer body when the spacer body is retained by the intervertebral implant frame.
5. The intervertebral implant frame of claim 4, wherein the first and second lengths each define a value, respectively, such that the support member, the first arm, and the second arm collectively extend around at least 80% but no more than 99% of the perimeter of the spacer body when the spacer body is retained by the intervertebral implant frame.
6. The intervertebral implant frame of claim 1, wherein the first and second arms are capable of retaining a spacer body consisting of cancellous bone.
7. The intervertebral implant frame of claim 1, wherein the first and second arms each include at least one retention member that extends out of the respective spacer contacting surface, and is configured to engage a spacer body.
8. The intervertebral implant frame of claim 1, wherein the first arm and the second arm are angled toward each other such that the inner surface of the support member and the first inner spacer contacting surface form an angle that is less than 90°, and the inner surface of the support member and the second inner spacer contacting surface form an angle that is less than 90°.
9. The intervertebral implant frame of claim 1, wherein the first and second lengths are between about 50% and 100% of an anterior-posterior length of the intervertebral space.
10. The intervertebral implant frame of claim 1, wherein the first and second arms each include a substantially straight portion that extends from the support member, and a distal bent portion that extends inward from a distal end of the substantially straight portion at an angle such that the bent portions are configured to contact a distal surface of a spacer body when the intervertebral implant frame is retaining the spacer body to thereby prevent the spacer body from separating from the intervertebral implant frame.
11. The intervertebral implant frame of claim 1, wherein the first and second arms each define a respective distal portion and a respective proximal portion, the distal portions each define a superior vertebral body contacting surface and an inferior vertebral body contacting surface, the proximal portions each define a superior vertebral body contacting surface and an inferior vertebral body contacting surface.
12. The intervertebral implant frame of claim 11, wherein a line drawn between the superior vertebral body contacting surfaces of the first arm forms an angle between about 0° and about −5° with respect to an insertion direction of the intervertebral implant frame, and a line drawn between the superior vertebral body contacting surfaces of the second arm forms an angle between about 0° and about −5° with respect to the insertion direction of the intervertebral implant frame.
13. The intervertebral implant frame of claim 12, wherein a line drawn between the inferior vertebral body contacting surfaces of the first arm forms an angle between about 0° and about 5° with respect to the insertion direction of the intervertebral implant frame, and a line drawn between the inferior vertebral body contacting surfaces of the second arm forms an angle between about 0° and about 5° with respect to the insertion direction of the intervertebral implant frame.
14. The intervertebral implant frame of claim 1, wherein the first and second arms each include a superior cut-out and an inferior cut-out to thereby provide visual access to the superior vertebral body and to the inferior vertebral body respectively when the intervertebral implant frame is disposed in the intervertebral space.
15. The intervertebral implant frame of claim 14, wherein the first and second arms each include a window that extends through the first and second arms to thereby provide visual access to a spacer body through the first and second arms when the intervertebral implant frame is retaining the spacer body.
16. The intervertebral implant frame of claim 1, wherein the first and second arms each include an expansion instrument engagement member.
17. The intervertebral implant frame of claim 16, wherein the expansion instrument engagement members each define a dove-tailed slot.
18. The intervertebral implant frame of claim 17, wherein the dove-tailed slots are each open at their distal ends, such that an expansion instrument can engage the dove-tailed slots in a direction that is opposite to an insertion direction of the intervertebral implant frame.
19. The intervertebral implant frame of claim 16, wherein the expansion instrument engagement members each define a slot that extends through the first and second arms.
20. The intervertebral implant frame of claim 1, wherein at least one of the first and second arms is flexible so as to be movable between the second position to a third position whereby the frame defines a third distance between the first and second contact locations along the first direction, the third distance less than the second distance.
21. An intervertebral implant frame comprising:
a support member that defines an inner surface and at least two fixation element receiving apertures that are each configured to receive a respective bone fixation element to thereby attach the frame to first and second vertebral bodies when the intervertebral implant frame is disposed in an intervertebral space defined by the first and second vertebral bodies;
a first flexible arm that extends from the support member and defines a first inner spacer contacting surface, a first outer surface opposite the first inner spacer contacting surface, and a first engagement member defined by the first outer surface;
a second flexible arm that extends from the support member and defines a second inner spacer contacting surface that is spaced from the first inner spacer contacting surface, a second outer surface opposite the second inner spacer contacting surface, and a second engagement member defined by the second outer surface, wherein the inner surface of the support member and the first and second inner spacer contacting surfaces at least partially define a void configured to receive a spacer body that ingrows with the first and second vertebral bodies when the spacer is disposed in the intervertebral space;
wherein the first and second engagement members are configured to receive respective first and second expansion forces from an expansion instrument prior to insertion of the spacer body into the void, such that at least one of the first and second flexible arms elastically expands with respect to the other of the first and second arms in response to the expansion force.
22. The intervertebral implant frame of claim 21 wherein the first and second arms each have a length that is between about 3.5 mm and about 12 mm.
23. The intervertebral implant frame of claim 22, wherein the first and second arms each have a length that is between about 6.0 mm and about 10 mm.
24. The intervertebral implant frame of claim 21, wherein the first and second arms each have a length such that the support member, the first arm, and the second arm extend around at least 51% but no more than 99% of the spacer body when the spacer body is retained by the intervertebral implant frame.
25. The intervertebral implant frame of claim 21, wherein the first and second arms are capable of retaining a spacer body consisting of cancellous bone, cortical bone, or both cancellous and cortical bone.
26. The intervertebral implant frame of claim 21, wherein the first and second arms each include at least one retention member that extends out of the first and second spacer contacting surfaces, respectively, and is configured to engage the spacer body.
27. The intervertebral implant frame of claim 26, wherein the first arm and the second arm are angled toward each other such that the inner surface of the support member and the first inner spacer contacting surface forms an angle that is less than 90°, and the inner surface of the support member and the second inner spacer contacting surface forms an angle that is less than 90°.
28. The intervertebral implant frame of claim 21, wherein the first vertebral body is a superior vertebral body, the second vertebral body is an inferior vertebral body, the first and second arms each define a respective distal portion and a respective proximal portion, the distal portions each define a superior vertebral body contacting surface and an inferior vertebral body contacting surface, the proximal portions each define a superior vertebral body contacting surface and an inferior vertebral body contacting surface.
29. The intervertebral implant frame of claim 28, wherein a line drawn between the superior vertebral body contacting surfaces of the first arm forms an angle between about 0° and about −5° with respect to an insertion direction of the intervertebral implant frame, the insertion direction substantially perpendicular to the first direction, and a line drawn between the superior vertebral body contacting surfaces of the second arm forms an angle between about 0° and about −5° with respect to the insertion direction of the intervertebral implant frame.
30. The intervertebral implant frame of claim 29, wherein a line drawn between the inferior vertebral body contacting surfaces of the first arm forms an angle between about 0° and about 5° with respect to the insertion direction of the intervertebral implant frame, and a line drawn between the inferior vertebral body contacting surfaces of the second arm forms an angle between about 0° and about 5° with respect to the insertion direction of the intervertebral implant frame.
31. The intervertebral implant frame of claim 21, wherein the first vertebral body is a superior vertebral body, the second vertebral body is an inferior vertebral body, the first and second arms each include a superior cut-out and an inferior cut-out to thereby provide visual access to the superior vertebral body and inferior vertebral body when the intervertebral implant frame is disposed in the intervertebral space.
32. The intervertebral implant frame of claim 31, wherein the first and second arms each include a window that extends through the first and second arms to thereby provide visual access to the spacer body through the first and second arms when the intervertebral implant frame is retaining the spacer body.
33. The intervertebral implant frame of claim 21, wherein the engagement members each define a dove-tailed slot.
34. The intervertebral implant frame of claim 33, wherein the dove-tailed slots are each open at their distal ends, such that the expansion instrument engages the dove-tailed slots in a direction that is: 1) opposite to an insertion direction of the intervertebral implant frame, and 2) substantially perpendicular to the first direction.
35. The intervertebral implant frame of claim 21, wherein the engagement members each define a slot that extends through the first and second arms.
36. The intervertebral implant frame of claim 21, wherein the first and second arms are configured to retain a first spacer body having a first maximum width and a second spacer body having a second maximum width that is different than the first maximum width.
37. The intervertebral implant frame of claim 21, wherein a first of the at least two fixation element receiving apertures is spaced from a second of the at least two fixation element receiving apertures by a first distance measured in a first direction, and the first and second engagement members are spaced from one another by a second distance measured in the first direction such that the second distance is greater than the first distance.
38. An intervertebral implant frame comprising:
a support member that defines an inner surface and at least two fixation element receiving apertures that are each configured to receive a respective bone fixation element to thereby affix the frame to superior and inferior vertebral bodies when the intervertebral implant frame is disposed in an intervertebral space that is defined by the superior and inferior vertebral bodies;
a first arm that extends from the support member and includes a first inner spacer contacting surface, and a first crimpable arm; and
a second arm that extends from the support member and includes a second inner spacer contacting surface spaced from the first inner spacer contacting surface along a first direction, and a second crimpable arm,
wherein the inner surface of the support member, and the first and second inner spacer contacting surfaces together define a void that is configured to receive a spacer body, and the first crimpable arm is configured to be bent toward the second arm, the second crimpable arm is configured to be bent toward the first arm to thereby engage the spacer body and retain the spacer body within the void, the intervertebral implant frame has a first position in which the spacer body can be disposed between the first arm and the second arm, and the intervertebral has a second position in which the first crimpable arm and the second crimpable arm are crimped toward each other to thereby apply a retention force to the spacer body.
39. The intervertebral implant frame of claim 38, wherein (i) the first arm includes a first hinge and the second arm includes a second hinge, and (ii) the first crimpable arm is configured to rotate about the first hinge and the second crimpable arm is configured to rotate about the second hinge.
40. The intervertebral implant frame of claim 38, wherein the first arm includes a third crimpable arm, and the second arm includes a fourth crimpable arm.
41. The intervertebral implant frame of claim 40, wherein (i) the first arm includes a third hinge and the second arm includes a fourth hinge, and (ii) the crimpable arm is configured to rotate about the third hinge and the fourth crimpable arm is configured to rotate about the fourth hinge.
42. The intervertebral implant frame of claim 38, wherein the first and second crimpable arms define crimping tabs that are configured to engage respective side surfaces of the spacer body.
43. The intervertebral implant frame of claim 42, wherein (i) the first arm includes a first hinge and the second arm includes a second hinge, and (ii) the first crimp tab is configured to rotate about the first hinge and the second crimp tab is configured to rotate about the second hinge.
44. The intervertebral implant frame of claim 43, wherein:
the first crimp tab includes a first inner spacer contacting surface configured to contact the spacer body when the spacer body is retained within the void, a first outer surface opposite the first inner spacer contacting surface, and a first engagement member defined by the first outer surface configured to receive a first expansion force from an expansion instrument prior to insertion of the spacer body into the void;
the second crimp tab includes a second inner spacer contacting surface configured to contact the spacer body when the spacer body is retained within the void, a second outer surface opposite the second inner spacer contacting surface, and a second engagement member defined by the second outer surface configured to receive a second expansion force from an expansion instrument prior to insertion of the spacer body into the void.
45. The intervertebral implant frame of claim 38, wherein the crimping tabs are disposed along an upper and lower edge of the first and second arms.
46. An intervertebral implant frame comprising:
a support member that defines an inner surface and at least two fixation element receiving apertures that are each configured to receive a respective bone fixation element to thereby attach the frame to first and second vertebral bodies when the intervertebral implant frame is disposed in an intervertebral space defined by the first and second vertebral bodies;
a first flexible arm that extends from the support member and defines a first inner spacer contacting surface;
a second flexible arm that extends from the support member and defines a second inner spacer contacting surface that is spaced from the first inner spacer contacting surface, wherein the inner surface of the support member and the first and second inner spacer contacting surfaces at least partially define a void configured to receive a spacer body that ingrows with the first and second vertebral bodies when the spacer is disposed in the intervertebral space;
wherein the first and second flexible arms include respective first and second engagement members define respective first and second dove-tailed slots that are configured to receive respective first and second expansion forces from an expansion instrument prior to insertion of the spacer body into the void, such that at least one of the first and second flexible arms elastically expands with respect to the other of the first and second arms in response to the expansion force.
47. The intervertebral implant frame of claim 46, wherein the first and second dove-tailed slots are each open at respective distal ends, such that the expansion instrument engages the dove-tailed slots in a direction that is opposite to an insertion direction of the intervertebral implant frame.
Descripción
CROSS REFERENCE TO RELATED APPLICATIONS

This application claims the benefit of U.S. Provisional Patent Application Ser. No. 61/425,505 filed Dec. 21, 2010 and U.S. Provisional Patent Application Ser. No. 61/425,509 filed Dec. 21, 2010, the contents of each of which are hereby incorporated by reference in their entirety herein.

BACKGROUND

Implants for spinal fusion typically include a spacer body to allow for growth of bone between adjacent vertebral bodies while restoring and maintaining intervertebral space height that is defined between the vertebral bodies. In some cases, a plate is used to provide stability during healing so as to allow the patient to quickly resume an active lifestyle. The profile of the plate, which is placed on the anterior aspect of the vertebral bodies, however, can lead to dysphasia or patient discomfort which has resulted in various “zero-profile” devices currently being developed. For example, one zero profile device is an intervertebral device that is inserted into the intervertebral space. While the threaded device provides graft retention, stability in flexion and extension is questionable since the device does not positively lock to the vertebral bodies during implantation.

Other intervertebral implants have been utilized that include a frame shaped in a manner so as to hold a spacer body made from PEEK. Such spacer bodies typically are customized to have complimentary features to the frame so that the spacer bodies may be affixed to the frame. Such frames may not be desirable for spacer bodies made from allograft, however, because allograft spacer bodies may vary in shape, may not include the complimentary features needed to be affixed to the frame, and may degrade or resorb overtime.

SUMMARY

In accordance with an embodiment, an intervertebral implant frame can be configured to retain a spacer body. The frame can include a support member, a first arm that extends from the support member, and a second arm that extends from the support member. The support member defines an inner surface, and at least two fixation element receiving apertures. Each of the fixation element receiving apertures is configured to receive a respective bone fixation element to thereby attach the intervertebral implant frame to first and second vertebral bodies, respectively when the intervertebral implant frame is disposed in an intervertebral space defined by first and second surfaces of the first and second vertebral bodies, respectively. The first arm includes a first inner spacer contacting surface, and defines a first terminal end. The second arm includes a second inner spacer contacting surface spaced from the first inner spacer contacting surface along a first direction. The second arm defines a second terminal end. The first and second terminal ends are each spaced from the support member along a second direction that is substantially perpendicular to the first direction so as to define first and second lengths, respectively. The first and second inner spacer contacting surfaces define at least first and second respective contact locations, and at least one of the first and second arms is flexible so as to be movable between a first position, whereby the frame defines a first distance between the first and second contact locations along the first direction, and a second position, whereby the frame defines a second distance between the first and second contact locations along the first direction. The second distance is greater than the first distance, such that when in the second position, the at least one of the first and second arms is biased toward the first position. The first and second lengths are each greater than a length defined between an anterior end of the first vertebral body and a centroid of the first surface.

In accordance with another embodiment, an intervertebral implant frame includes a support member, a first flexible arm that extends from the support member, and a second flexible arm that extends from the support member. The support member defines an inner surface and at least two fixation element receiving apertures that are each configured to receive a respective bone fixation element to thereby attach the frame to first and second vertebral bodies. The first flexible arm defines a first inner spacer contacting surface. The second flexible arm defines a second inner spacer contacting surface that is spaced from the first inner spacer contacting surface. The inner surface of the support member and the first and second inner spacer contacting surfaces at least partially define a void configured to receive a spacer body that ingrows with the first and second vertebral bodies. The first and second flexible arms include respective first and second engagement members that are configured to receive respective first and second expansion forces from an expansion instrument prior to insertion of the spacer body into the void such that at least one of the first and second flexible arms elastically expands with respect to the other of the first and second arms in response to the expansion force.

In accordance with another embodiment, an intervertebral implant frame includes a support member, a first flexible arm that extends from the support member, and a second flexible arm that extends from the support member. The support member defines an inner surface, and at least two fixation element receiving apertures. Each of the fixation element receiving apertures is configured to receive a respective bone fixation element to thereby attach the intervertebral implant frame to first and second vertebral bodies, respectively when the intervertebral implant frame is disposed in an intervertebral space defined by first and second surfaces of the first and second vertebral bodies, respectively. The first flexible arm includes a first inner spacer contacting surface. The first arm has a first distal portion and a first proximal portion. The first distal portion and the first proximal portion each define a superior vertebral body contacting surface and an inferior vertebral body contacting surface. The second flexible arm includes a second inner spacer contacting surface spaced from the first inner spacer contacting surface along a first direction. The second arm has a second distal portion and a second proximal portion. The second distal portion and the second proximal portion each define a superior vertebral body contacting surface and an inferior vertebral body contacting surface. The first and second distal portions are configured to support the first and second vertebral bodies relative to each other on a posterior side of a plane that intersects a centroid of the first surface and the first and second posterior portions are configured to support the first and second vertebral bodies relative to each other on an anterior side of the plane that intersects the centroid of the first surface, when the intervertebral implant frame is disposed in the intervertebral space.

In accordance with another embodiment, an intervertebral implant frame includes a support member, a first arm that extends from the support member, and a second arm that extends from the support member. The support member defines an inner surface and at least two fixation element receiving apertures that are each configured to receive a respective bone fixation element to thereby affix the frame to superior and inferior vertebral bodies. The first arm includes a first inner spacer contacting surface, and a first crimp member. The second arm includes a second inner spacer contacting surface spaced from the first inner spacer contacting surface along a first direction, and a second crimp member. The inner surface of the support member, and the first and second inner spacer contacting surfaces together define a void that is configured to receive a spacer body. The first crimp member is configured to be bent toward the second arm, and the second crimp member is configured to be bent toward the first arm to thereby engage the spacer body and retain the spacer body within the void.

In accordance with another embodiment, an intervertebral implant includes a support member, a first arm that extends from the support member, and a second arm that extends from the support member. The support member defines an inner surface, and at least two fixation element receiving apertures. Each of the fixation element receiving apertures is configured to receive a respective bone fixation element to thereby attach the frame to first and second vertebral bodies, respectively when the frame is disposed in an intervertebral space defined by the first and second vertebral bodies. The first arm includes a first inner spacer contacting surface. The second arm includes a second inner spacer contacting surface spaced from the first inner spacer contacting surface along a first direction. The inner surface of the support member and the first and second inner spacer contacting surfaces at least partially define a void that contains an allograft spacer. The first and second arms are elastically flexible from a first position to a second position, such that when the arms are in the second position, the void defines a cross-sectional dimension greater than that of the allograft spacer such that the void is sized to receive the allograft spacer body. When the first and second arms are in the first position, the first and second inner spacer contacting surfaces apply a retention force against the allograft spacer body along a direction toward the other of the first and second spacer contacting surfaces.

In accordance with another embodiment, an intervertebral implant system can include an intervertebral implant frame, and an expansion instrument. The intervertebral implant frame is configured to retain a spacer body. The frame has a support member that defines an inner surface, a first arm extending from the support member and defining a first inner spacer contacting surface, and a second arm extending from the support member and defining a second inner spacer contacting surface that is spaced from the first inner spacer contacting surface. The expansion instrument includes a first expansion arm that is configured to couple to the first arm, and a second expansion arm that is configured to couple to the second arm. The first and second arms are pivotally coupled to each other at a first pivot such that rotation of the first and second expansion arms about the first pivot causes the first and second arms to elastically flex away from each other when the first and second expansion arms are coupled to the first and second arms, respectively.

Also disclosed is a spacer body drill guide constructed in accordance with an embodiment. The drill guide includes a clamp and a cradle. The clamp includes a first jaw and a second jaw that are translatable along a first direction with respect to each other. The first jaw defines a first outer surface, a first inner spacer contacting surface, and a pair of first drill guide apertures that extend from the first outer surface to the first inner spacer contacting surface along a direction that is transverse to the first direction. The second jaw defines a second outer surface, a second inner spacer contacting surface, and a pair of second drill guide apertures that extend from the second outer surface to the second inner spacer contacting surface along a direction that is transverse to the first direction. The cradle includes a base and a mounting portion that extends from the base along a second direction that is substantially perpendicular to the first direction. The mounting portion includes a body, a channel that extends into the body along the second direction, and a pair of third drill guide apertures that extend through the body and into the channel at a direction that is transverse to the second direction. The channel is configured to receive the first jaw such that the first drill guide apertures align with the third drill guide apertures when the clamp is mounted to the cradle.

BRIEF DESCRIPTION OF THE DRAWINGS

The foregoing summary, as well as the following detailed description of embodiments of the application, will be better understood when read in conjunction with the appended drawings. For the purposes of illustrating the methods, implants and systems of the present application, there is shown in the drawings preferred embodiments. It should be understood, however, that the application is not limited to the precise methods, implants, and systems shown. In the drawings:

FIG. 1A is a perspective view of an intervertebral implant assembly that is implanted in an intervertebral space defined by a superior vertebral body and an inferior vertebral body, the intervertebral implant assembly including an intervertebral implant and at least a pair of fixation elements that attach the intervertebral implant to the superior vertebral body and the inferior vertebral body, respectively;

FIG. 1B is a side elevation view of the intervertebral implant assembly as shown in FIG. 1A, the intervertebral space defining an anterior-posterior midline;

FIG. 1C is a top plan view of the inferior vertebral body shown in FIG. 1B;

FIG. 2A is a perspective view of the intervertebral implant illustrated in FIGS. 1A and 1B, the intervertebral implant having an intervertebral implant frame and a spacer body retained by the intervertebral implant frame;

FIG. 2B is a top plan view of the intervertebral implant shown in FIG. 2A;

FIG. 3A is a perspective view of the intervertebral implant frame shown in FIG. 2, the intervertebral implant frame having a support member, a first arm extending from the support member, and a second arm extending from the support member, the first and second arms configured to elastically flex away from each other;

FIG. 3B is a front elevation view of the intervertebral implant frame shown in FIG. 3A;

FIG. 3C is a top plan view of the intervertebral implant frame shown in FIG. 3A;

FIG. 3D is a side elevation view of the intervertebral implant frame shown in FIG. 3A;

FIG. 3E is a cross-sectional view of the intervertebral implant frame shown in FIG. 3D through the line 3E-3E;

FIG. 4A is a perspective view of one of the fixation elements that is configured to affix the intervertebral implant shown in FIG. 2 to a vertebral body as illustrated in FIGS. 1A and 1B;

FIG. 4B is a side elevation view of the of the fixation element shown in FIG. 4A;

FIG. 5A is a perspective view of a spacer body made from bone graft;

FIG. 5B is a perspective view of the spacer body shown in FIG. 2;

FIG. 5C is a top plan view of the spacer body shown in FIG. 5B;

FIG. 5D is a side elevation view of the spacer body shown in FIG. 5B;

FIG. 6A is a perspective view of an intervertebral implant system constructed in accordance with an embodiment, the system including an actuation instrument configured as an expansion instrument that includes an actuation grip illustrated as an expansion grip that is configured to actuate the frame shown in FIG. 3A from a first configuration to a second configuration whereby the frame is configured to receive the spacer body shown in FIG. 5B;

FIG. 6B is a perspective view of the expansion instrument shown in FIG. 6A, the expansion instrument including a first expansion arm and a second expansion arm coupled to the first expansion arm at a first pivot, each expansion arm having a handle portion and a gripping portion that combine to define a handle of the expansion instrument and the expansion grip illustrated in FIG. 6A;

FIG. 6C is a top plan view of the expansion instrument shown in FIG. 6B;

FIG. 6D is a detailed view of one of the gripping portions of the expansion instrument shown in FIG. 6B;

FIG. 6E is an enlarged top plan view of the expansion grip shown in FIG. 6B, coupled to the first and second arms of the frame shown in FIG. 3A, showing the expansion instrument actuated from a first position to a second position, whereby the expansion grip applies an expansion force to the first and second arms of the frame when the expansion instrument is in the second position, the expansion force biasing the first and second arms of the frame to flex away from each other;

FIG. 7A is a perspective view of an intervertebral implant system constructed in accordance with another embodiment, the system including a intervertebral implant frame, and an actuation instrument configured as an expansion instrument that comprises a pair of clips that engage first and second arms of the frame along a direction that is similar to an insertion direction of the frame;

FIG. 7B is a top plan view of the intervertebral implant system shown in FIG. 7A;

FIG. 7C is an exploded view of the intervertebral implant system shown in FIG. 7A;

FIG. 8A is a perspective view of an intervertebral implant system constructed in accordance with another embodiment, the system including a intervertebral implant frame and an actuation instrument configured as an expansion instrument that comprises a pair of clips that engage first and second arms of the frame along a direction that is opposite to the insertion direction of the frame;

FIG. 8B is a top plan view of the system shown in FIG. 8A;

FIG. 8C is an exploded view of the system shown in FIG. 8A;

FIG. 9A is a perspective view of an intervertebral implant frame constructed in accordance with another embodiment, the frame including a first arm, a second arm, and a respective expansion member that extends out from and is integral to a respective arm of the frame;

FIG. 9B is a perspective view of an intervertebral implant frame constructed in accordance with another embodiment, the frame including, a support member, a first arm, a second arm, and a respective expansion member that extends out from and is integral to each arm of the frame, the expansion members extending proximate to the support member;

FIG. 10A is a perspective view of an intervertebral implant frame constructed in accordance with another embodiment, the frame including first and second arms that each include a crimp member configured to be crimped against the spacer body to thereby retain the spacer body to the frame;

FIG. 10B is a top plan view of the frame shown in FIG. 10A;

FIG. 11A is a perspective view of an intervertebral implant frame constructed in accordance with another embodiment, the frame including first and second arms that each include a pair of crimp members configured to be crimped against the spacer body to thereby retain the spacer body to the frame;

FIG. 11B is a top plan view of the frame shown in FIG. 11A;

FIG. 12A is a perspective view of an intervertebral implant frame constructed in accordance with another embodiment, the frame including first and second arms that each include a crimp member configured as a crimp tab disposed within a window defined by the arm;

FIG. 12B is a top plan view of the frame shown in FIG. 12A;

FIG. 13A is a perspective view of an intervertebral implant frame constructed in accordance with another embodiment, the frame including first and second arms that each include at least one crimp member configured as a crimp tab;

FIG. 13B is a top plan view of the frame shown in FIG. 13A;

FIG. 14A is a perspective view of an actuation instrument configured as a crimping instrument constructed in accordance with an embodiment, the instrument including gripping members that are configured to crimp the crimp members of the frames shown in FIGS. 10A and 11A;

FIG. 14B is a detailed top plan view of the gripping members of the instrument shown in FIG. 14A, and an intervertebral implant disposed between the gripping members;

FIG. 14C is a top plan view of the gripping members illustrated in FIG. 14B, shown in a crimped position, whereby the crimp members are crimped onto a spacer body of the intervertebral implant so as to secure the arms to the intervertebral implant;

FIG. 14D is a detailed view of gripping members of a crimping instrument constructed in accordance with another embodiment, the gripping members including a beaked protrusion configured to crimp the crimp members of the frame shown in FIG. 12A;

FIG. 15A is a perspective view of an intervertebral implant frame constructed in accordance with another embodiment, the frame defining a four walled structure;

FIG. 15B is a top plan view of the frame shown in FIG. 15A;

FIG. 16A is a perspective view of a spacer body drill guide constructed in accordance with an embodiment, the drill guide including a clamp, and a cradle that is configured to mate with and support the clamp;

FIG. 16B is a perspective view of the clamp shown in FIG. 16A;

FIG. 16C is a perspective view of the clamp being mounted to the cradle;

FIG. 16D is a perspective view of the clamp after it has been mounted to the cradle;

FIG. 16E is a perspective view of a drill bit being inserted into drill guide apertures defined by the clamp to thereby form clearance channels in the spacer body; and

FIG. 16F is a perspective view of a spacer body after the clearance channels have been formed using the drill guide shown in FIG. 16A.

DETAILED DESCRIPTION

Referring to FIGS. 1A and 1B, a superior vertebral body 10 a defines a first or superior vertebral surface 14 a of an intervertebral space 18, and an adjacent second or inferior vertebral body 10 b defines an inferior vertebral surface 14 b of the intervertebral space 18. Thus, the intervertebral space 18 is disposed between or otherwise defined by the vertebral bodies 10 a and 10 b. The vertebral bodies 10 a and 10 b can be anatomically adjacent vertebral bodies, or can remain after a portion of bone has been removed. The intervertebral space 18 can be disposed anywhere along the spine as desired, including at the lumbar, thoracic, and cervical regions of the spine. As illustrated, the intervertebral space 18 is illustrated after a discectomy, whereby the disc material has been removed or at least partially removed to prepare the intervertebral space 18 to receive an intervertebral implant 22 that can achieve height restoration. As shown, the intervertebral implant 22 can be affixed to the superior and inferior vertebral bodies 10 a and 10 b with respective fixation elements 62. The intervertebral implant 22 and the fixation elements 62 together define an intervertebral implant assembly 24.

Certain terminology is used in the following description for convenience only and is not limiting. The words “right”, “left”, “lower” and “upper” designate directions in the drawings to which reference is made. The words “inner” or “distal” and “outer” or “proximal” refer to directions toward and away from, respectively, the geometric center of the implant and related parts thereof. The words, “anterior”, “posterior”, “superior,” “inferior,” “medial,” “lateral,” and related words and/or phrases are used to designate various positions and orientations in the human body to which reference is made and are not meant to be limiting. The terminology includes the above-listed words, derivatives thereof and words of similar import.

The intervertebral implant 22 is described herein as extending horizontally along a longitudinal direction “L” and lateral direction “A”, and vertically along a transverse direction “T”. Unless otherwise specified herein, the terms “lateral,” “longitudinal,” and “transverse” are used to describe the orthogonal directional components of various components. It should be appreciated that while the longitudinal and lateral directions are illustrated as extending along a horizontal plane, and that the transverse direction is illustrated as extending along a vertical plane, the planes that encompass the various directions may differ during use. For instance, when the intervertebral implant 22 is implanted into the intervertebral space 18 along an insertion direction I, the transverse direction T extends vertically generally along the superior-inferior (or caudal-cranial) direction, while the horizontal plane defined by the longitudinal direction L and lateral direction A lies generally in the anatomical plane defined by the anterior-posterior direction, and the medial-lateral direction, respectively. Accordingly, the directional terms “vertical” and “horizontal” are used to describe the intervertebral implant 22 and its components as illustrated merely for the purposes of clarity and illustration.

As shown in FIGS. 1B and 1C, the vertebral surfaces 14 a and 14 b of the vertebral bodies 10 a and 10 b can define a geometrical centroid M that is generally located at an anterior-posterior midpoint between an anterior end and a posterior end of the surfaces 14 a and 14 b. As shown in FIG. 1B, the intervertebral implant 22 is configured to be disposed or otherwise implanted in the intervertebral space 18 such that a portion of the intervertebral implant 22 is located on a posterior side of a medial lateral plane that intersects the centroid M, and a portion of the intervertebral implant 22 is located on an anterior side of the medial lateral plane that intersects the centroid M. Such a configuration can ensure that the height restoration of the intervertebral space 18 remains relatively unchanged over time.

In reference to FIGS. 1A, 1B, 2A and 2B, the intervertebral implant 22 includes an intervertebral implant frame 26 and a spacer body 30 that is retained by the frame 26. The intervertebral implant 22, defines a proximal end P and a distal end D. The frame 26 may be made from any biocompatible material, such as TAN alloy, or PEEK. The spacer body 30 may be composed of a synthetic material such as PEEK or a graft substitute such a tricalcium phosphate or hydroxyapatite. The spacer body 30 may also be composed of a bone graft such as allograft bone, autograft bone or xenograft bone. By using a spacer body 30 composed of bone graft, surface area for fusion can be maximized. Additionally, incorporation of a bone graft spacer body 30 promotes bony on-growth and increased probability and speed of sound fusion. The frame 26 is configured to be attached to various bone graft spacer body footprint geometries, which may or may not conform to the internal footprint of the frame 26.

As shown in FIGS. 3A-3E the frame 26 includes a support member 34, a first arm 38 that extends from the support member 34, and a second arm 42 that extends from the support member 34. In the illustrated embodiment, the first and second arms 38 and 42 are flexible arms that extend from opposed ends of the support member 34 such that the support member 34, the first arm 38, and the second arm 42 together create a three wall structure that retains and secures the spacer body 30 to the frame 26.

As shown in FIGS. 3A-3C, the support member 34 includes a body 46 that defines an inner surface 50, an outer surface 54, and at least one, such as two or such as four, fixation element receiving apertures 58 that extend through the body 46 from the outer surface 54 to the inner surface 50. Each fixation element receiving aperture 58 is configured to receive a respective fixation element, such as fixation element 62 shown in FIGS. 4A and 4B. While the fixation elements 62 are illustrated as screws, it should be appreciated that the fixation elements 62 may also be nails or any other fixation element configured to attach the intervertebral implant 22 to the first and second vertebral bodies 10 a and 10 b. As shown, the support member 34 can further include at least one, such as three tabs 64 that extend transversely from the body 46. The tabs 64 may sit on an anterior side of the vertebral bodies and prevent over-insertion of the frame 26 into the intervertebral space 18. In the illustrated embodiment, the support member 34 includes two superior tabs 64 and one inferior tab 64 that are each configured to sit flush or slightly proud of an anterior surface of the vertebral bodies depending on the patient's spinal anatomy and/or site preparation. It should be appreciated, however, that the support member 34 can include other configurations for the tabs 64. For example, the support member 34 can include a single superior tab 64 and two inferior tabs 64.

As shown in FIG. 3B, two of the fixation element receiving apertures 58 are inner apertures 66 that extend through the body 46 at a downward angle relative to the insertion direction I, and two of the fixation element receiving apertures 58 are outer apertures 70 that extend through the body 46 at an upward angle relative to the insertion direction I. The inner apertures 66 are configured to receive respective fixation elements, such as fixation element 62 shown in FIGS. 4A and 4B, to thereby attach the intervertebral implant 22 to the inferior vertebral body 10 b. Similarly, the outer apertures 70 are configured to receive respective fixation elements 62 to thereby attach the intervertebral implant 22 to the superior vertebral body 10 a. It should be appreciated, however, that the inner apertures 66 can extend through the body 46 at an upwards angle and the outer apertures 70 can extend through the body 46 at a downwards angle, as desired. Moreover, it should be appreciated that the support member 34 can define any number of fixation element receiving apertures 58 as desired.

As shown in FIG. 3B, the apertures 58 each define internal threads 78. The internal threads 78 are configured to engage external threads 80 defined by a head 82 of the respective fixation element 62 that is received within the apertures 58. It should be appreciated, however, that the apertures 58 can be void of threads as desired. The orientation of the apertures 58 may be configured such that the fixation elements that are received by the apertures 58 may have an insertion variance of +/−5 degrees and do not allow toggling or settling. Once fully received, the fixation elements may lock to the frame 26 to thereby increase the surgeon's reassurance of good screw trajectories and can act as a safety by preventing possibilities of over-insertion during implantation.

As shown in FIG. 3C, support member 34 can include a retention member 73 that extends from the inner surface 50. The retention member 73 is configured to help retain the spacer body 30 when the spacer body is being supported by the frame 26. The retention member 73 is illustrated as a spike though it should be appreciated, that the retention member 73 can have other configurations. For example, the retention member 73 can be configured as a blade.

As shown in FIGS. 2A, and 3A-3E, the first arm 38 and the second arm 42 each extend from the support member 34 and define a first distal terminal end 83 and a second distal terminal end 84, respectively. The first and second arms 38 and 42 each define gripping portions and support portions. The gripping portions are configured to retain the spacer body 30 while the support portions are configured to support the vertebral bodies 10 a and 10 b relative to each other. The gripping portions and the support portions can be a single structure or the support portions can be separate structures that extend from the gripping portions. The arms 38 and 42 can be radiolucent so as to increase fluoroscopy visibility. The first arm 38 includes a first inner spacer contacting surface 88 and the second arm 42 includes a second inner spacer contacting surface 92 that is spaced from the first inner spacer contacting surface 88 along a first direction, such as the lateral direction A. The inner surface of the support member 34, the first inner spacer contacting surface 88, and the second inner spacer contacting surface 92 together define a void 94 that is configured to receive and grip the spacer body 30. The terminal ends 83 and 84 are spaced apart from the support member along a second direction, such as the longitudinal direction L that is substantially perpendicular to the first direction so as to define first and second lengths L1 and L2, respectively of the first and second arms 38 and 42. The first and second arms 38 and 42 are sized such that the first and second lengths L1 and L2 are each greater than a length L3 defined between an anterior end E of the inferior vertebral body 10 b and the centroid M of the surface 14 b of the inferior vertebral body 10 b, as shown in FIG. 1C. It should be appreciated, that the first and second arms 38 and 42 can also be sized such that the first and second lengths L1 and L2 are greater than a length defined between an anterior end of the superior vertebral body 10 a and a centroid of the surface 14 a of the superior vertebral body 10 a. The first and second lengths L1 and L2 may be between about 3.5 mm and about 12 mm, between about 6.0 mm and about 10 mm, and preferably about 9.5 mm. In some embodiments, the support member 34, the first arm 38, and the second arm 42 extend around at least 51% of the spacer body 30, and preferably around at least 80% of the spacer body 30.

The flexible arms 38 and 42 can have a transverse height and a lateral width that at least partially define a cross-sectional area of the arms 38 and 42. The arms 38 and 42 can have a cross-sectional area that may vary so long as the arms 38 and 42 are capable of elastically deforming or flexing to thereby allow the frame 26 to receive the spacer body and subsequently apply a retention force to the spacer body 30 after the frame 26 has received the spacer body 30. In that regard, the arms 38 and 42 are configured to elastically flex laterally outwardly away from each other, or otherwise elastically deform from a first position to a second flexed position to allow the frame 26 to receive the spacer body 30. It should be appreciated that the first position can be a relaxed position of the arms 38 and 42 or a flexed position of the arms 38 and 42 that is outwardly flexed with respect to a relaxed position. At least respective portions of the arms 38 and 42, such as contact locations 320 and 324 (see FIG. 6E), are further spaced from each other in the second position than when in the first position. Once the spacer body 30 is disposed between the arms 38 and 42, the arms 38 and 42 may flex inwardly toward each other to a third or engaged position whereby the arms 38 and 42 engage the spacer body 30 so as to secure the frame 26 to the spacer body 30 as shown in FIG. 2. It should be appreciated that the third position can be outwardly flexed with respect to the first position, and can be substantially equal to the first position. Thus, the respective portions of the arms 38 and 42 can be further spaced from each other when in the third position with respect to the first position, or the respective portions of the arms 38 and 42 can be spaced from each other when in the third position a distance substantially equal to the distance that the respective portions of the arms 38 and 42 are spaced when in the first position. Thus, it can be said that when the arms 38 and 42 are in the third position, at least respective portions of the arms 38 and 42 are spaced apart a distance equal to or greater than (or no less than) the distance that the arms 38 and 42 are spaced when in the first position. It will be further appreciated from the description below in accordance with certain embodiments (see, for instance FIG. 14C) that at least respective portions of the arms 38 and 42 can be spaced apart a distance when in the engaged position that is less than the distance that the respective portions of the arms 38 and 42 are spaced apart when in the first position.

As shown in FIG. 3C, the first and second arms 38 and 42 extend from the support member 34 such that the first and second arms 38 and 42 are angled toward each other so as to push the spacer body 30 toward the other of the first and second arms 38 and 42 and toward the support member 34. For example, the inner surface of the support member 34 and the first inner spacer contacting surface 88 form an angle Ø1 that is less than 90 degrees, and the inner surface 50 of the support member 34 and the second inner spacer contacting surface 92 form an angle Ø2 that is less than 90 degrees. In the illustrated embodiment, Ø1 and Ø2 are each about 88 degrees, though it should be appreciated that Ø1 and Ø2 may be any angle as desired, and may be different angles with respect to each other.

As shown in FIGS. 3C and 3D, each arm 38 and 42 includes a substantially straight portion 100 that extends from the support member 34, and a distal bent or angled portion 104 that extends from a distal end of the straight portion 100 toward the other of the bent portions 104 such that the bent portions 104 are configured to contact a distal surface of the spacer body 30. As shown, the bent portions 104 at least partially wrap around the spacer body 30 to thereby prevent the spacer body 30 from separating from the frame 26 after the spacer body 30 has been retained by the frame 26. As shown in FIG. 3A, each arm 38 and 42 can include at least one, such as a plurality of retention members 116 that extend out from the first and second inner spacer contacting surfaces 88 and 92. In the illustrated embodiment, the retention members 116 define teeth that extend out of the bent portions 104 so as to form a column of teeth on each bent portion 104. The retention members 116 are configured to engage the spacer body 30 when the frame 22 is retaining the spacer body 30 to thereby ensure that the spacer body 30 remains retained by the frame 22. It should be appreciated, however, that the retention member 116 can have any configuration as desired, so long as the retention member 116 is capable of engaging the spacer body 30. For example, the retention members 116 can be spikes that extend from the inner surfaces 88 and 92 at an angle, elongate blades, or even punches that can be punched into the spacer body 30 by an individual after the spacer body 30 is disposed in the frame 26.

As shown in FIG. 3D, the arms 38 and 42 may be configured to assist in bearing compressive loads by the vertebral bodies 10 a and 10 b to thereby mitigate subsidence and settling. As shown, each arm 38 and 42 defines a respective distal portion 110 and a respective proximal portion 114. The distal portions 110 are spaced apart from the proximal portions 114 along the longitudinal direction L such that when the frame 26 is disposed in the intervertebral space 18, the distal portions 110 are on the posterior side of the centroid M of the surface 14 b of the inferior vertebral body 10 b, and the proximal portions 114 are on the anterior side of the centroid M of the surface 14 b of the inferior vertebral body 10 b. Each distal portion 110 defines a superior vertebral body contacting surface 118 and an inferior vertebral body contacting surface 122. Similarly, each proximal portion 114 defines a superior vertebral body contacting surface 126 and an inferior vertebral body contacting surface 130. Because of the length of the arms 38 and 42 and because of the transverse height of the arms 38 and 42 at their distal and proximal portions, the frame 26 can bear compressive loads from the vertebral bodies if the spacer body 30 were to subside.

As shown in FIG. 3D, the arms 38 and 42 may be configured to conform to the lordotic curve of the spine and in particular of the intervertebral space 18 in which the frame 26 is to be disposed. For example, a line drawn between the superior vertebral body contacting surfaces 118 and 126 of the first arm 38 forms an angle that is between about 0 degrees and about −5 degrees with respect to the insertion direction I, and a line drawn between the inferior vertebral body contacting surfaces 122 and 130 of the first arm forms a line that is between about 0 degrees and about 5 degrees with respect to the insertion direction I. Similarly, a line drawn between the superior vertebral body contacting surfaces 118 and 126 of the second arm 42 forms an angle that is between about 0 degrees and about −5 degrees with respect to the insertion direction, and a line drawn between the inferior vertebral body contacting surfaces 122 and 130 of the second arm 42 forms an angle that is between about 0 degrees and about 5 degrees with respect to the insertion direction I. It should be appreciated, however, that the lines drawn between the superior vertebral body contacting surfaces 118 and 126, and between the inferior vertebral body contacting surfaces 122 and 130 can be any angle as desired. For example, the lines may be parallel to each other. Therefore, it can be said that a first plane is defined by the superior vertebral body contacting surfaces, and a second plane is defined by the inferior vertebral body contacting surfaces. The first plane and the second plane can be parallel to each other or converge toward each other.

As shown in FIG. 3D, each arm 38 and 42 further includes a superior cut-out 140 and an inferior cut-out 144 to thereby provide visual access to the superior vertebral body 10 a and to the inferior vertebral body 10 b respectively when the frame 26 is disposed in the intervertebral space 18. The cut-outs 140 and 144 are each disposed between the proximal portions 114 and distal portions 110 of the first and second arms 38 and 42. As shown, the superior cut-outs 140 extend laterally through an upper portion of the arms 38 and 42 so as to define upper curved recesses 148 in the straight portions 100 of the arms 38 and 42. Similarly, the inferior cut-outs 144 extend laterally through a lower portion of the arms 38 and 42 so as to define lower curved recesses 152 in the arms 38 and 42. It should be appreciated that the superior and inferior cut-outs 140 and 144 can have other configurations as desired. For example, the cut-outs 140 and 144 can define rectangular channels that extend through the arms 38 and 42.

As shown in FIGS. 3D and 3E, each arm 38 and 42 can further include a window 156 that extends laterally through the straight portions 100 of the arms 38 and 42 between the superior and inferior cut-outs 140 and 144. The windows 156 are configured to provide visual access to the spacer body 30 through the first and second arms 38 and 42 when the frame 26 is retaining the spacer body 30. As shown, the windows 156 are oval shaped and elongate along the longitudinal direction L. It should be appreciated, however, that the windows 156 can have any shape as desired. For example, the windows 156 can also be rectangular shaped.

As shown in FIGS. 3A, 3D, and 3E, each arm 38 and 42 includes an engagement member 170 that is configured to receive a first and a second external expansion force, respectively, from an expansion instrument prior to insertion of the spacer body 30 into the void 94 such that at least one of the first and second arms 38 and 42 elastically expands or elastically flexes with respect to the other of the first and second arms 38 and 42 in response to the expansion forces. As shown in FIG. 3A, the engagement members 170 each define a dove-tailed slot 174 that defines an opening 178 at its distal end such that the expansion instrument can engage the dove-tailed slot 174 in a direction that is opposite to the insertion direction I of the frame 26. As shown in FIG. 3D, the dove-tailed slots 174 are wider at the openings 178 and taper as they extend proximally. The wider openings 178 provide a guide for the expansion instrument to engage the engagement members 170. As shown in FIG. 3A, the dove-tailed slots 174 each include a pair of opposed recesses 182 that define angled engagement surfaces 186. It should be appreciated, however, that the engagement members 170 can have any configuration as desired so long as they can receive respective expansion forces.

Now referring to FIG. 5A, the spacer body 30 that is received within the frame 26 is preferably made from a bone graft material such as allograft bone, autograft bone, or xenograft bone, for example. As shown in FIG. 5A, the spacer body 30 can include cancellous bone 190 that is at least partially surrounded by cortical bone 194. It should be appreciated, however, that the spacer body 30 can be made from only cancellous bone 190 or from only cortical bone 194.

As shown in FIGS. 5B-5D, the spacer body can alternatively be made from a synthetic material. Referring to FIGS. 5B-5D, the spacer body 30 is sized and dimensioned to fit within the frame 26. Though not required, the spacer body may have a lateral width of between about 10 mm and about 16 mm, a longitudinal length of between about 10 mm and 17 mm, and a transverse height that is between about 5 mm and about 12 mm. The outer footprint of the spacer body 30 can vary and the frame 26 may still be able to retain the spacer body 30. That is, the frame 26 or at least the arms 38 and 42 are configured to retain a first spacer body 30 having a first maximum width, a first outer footprint, or a first cross-sectional dimension, and a second spacer body having a second maximum width, a second outer footprint, or a second cross-sectional dimension that is different than those of the first spacer body 30. Therefore, the frame 26 and in particular the arms 38 and 42 can retain spacer bodies 30 that are made from bone shaped by the surgeon and not just spacer bodies 30 that are machined to have specific dimensions prior to insertion into the frame 26.

As shown in FIGS. 5B-5D, the spacer body 30 can define a superior or upper or outer bone engaging surface 200 and an opposed inferior or lower or outer bone engaging surface 204. The surfaces 200 and 204 are configured to engage the superior and inferior surfaces 14 a and 14 b, respectively of the vertebral bodies 10 a and 10 b. The spacer body 30 can further define side surfaces 208 that are configured to be engaged by the first and second inner spacer contacting surfaces of the first and second arms 38 and 42 to thereby retain the spacer body 30 within the frame 26.

As shown in FIGS. 6A-6E, the spacer body 30 can be coupled to the frame 26 using an actuation instrument 210 that is configured as an expansion instrument. The instrument 210, the frame 26, and in some cases the spacer body 30 can together define an intervertebral implant system 214. The expansion instrument 210 includes a grip 212 and a handle 213. The grip 212 is configured as an expansion grip and is configured to apply the first and second expansion forces to the engagement members 170 of the first and second arms 38 and 42. The first and second expansion forces will elastically expand the first and second arms 38 and 42 of the frame 26 to thereby allow the spacer body 30 to be received by the void 94 of the frame 26.

As shown, the instrument 210 includes a first arm 220 that is configured to releasably couple to the first arm 38 of the frame 26, and a second arm 224 that is rotatably coupled to the first arm 220 at a first pivot 228 and is configured to releasably couple to the second arm 42 of the frame 26. The first and second arms 220 and 224 are configured as expansions arms. The first and second expansion arms 220 and 224 are pivotally coupled to each other at the first pivot 228 such that rotation of the first and second expansion arms 220 and 224 about the first pivot 228 causes the first and second arms 38 and 42 of the frame 26 to elastically flex away from each other when the instrument 210 is coupled to the frame 26. Therefore, the instrument 210 is configured to have a first position or configuration whereby the instrument 210 can be coupled to the frame 26, and a second position or configuration whereby the instrument 210 is applying expansion forces to the arms 38 and 42 of the frame 26 so that the frame can receive the spacer body 30.

As shown in FIGS. 6B and 6C, each expansion arm 220 and 224 includes a handle portion 232 that extends proximally from the first pivot 228 and a gripping portion 236 that extends distally from the first pivot 228. The handle portions 232 define the handle 213, and the gripping portions 236 define the grip 212. The handle portions 232 are configured to be gripped by an individual such that the handle portions 232 can be squeezed or otherwise moved toward each other. The expansion instrument 210 can further include a handle locking mechanism 240 that is configured to lock the handle portions 232 relative to each other after the handle portions 232 have been moved toward each other. In the illustrated embodiment, the locking mechanism 240 includes a threaded shaft 244 and a nut 248. As at least one of the handle portions 232 is moved along the shaft 244, the nut 248 can be threaded along the shaft 244 to thereby lock the handle portions 232 relative to each other. It should be appreciated, however, that the locking mechanism 240 can include other configurations, as desired. For example, the locking mechanism 240 can have a ratchet configuration.

As shown in FIGS. 6C and 6D, the gripping portions 236 are configured to expand the frame arms as the handle portions 232 are moved toward each other. Each gripping portion 236 includes an extension member 250 that extends distally from the first pivot 228, and a gripping member 254 that is pivotally coupled to a distal end of the extension member 250 at a second pivot 258. Each gripping member 254 includes an engagement member 262 that is configured to engage respective engagement members 170 of the first and second arms 38 and 42 of the frame 26. As shown in FIG. 6D, the engagement members 262 are dove-tailed members 266 that are opposed to each other and are configured to mate with the dove-tailed slots of the first and second arms 38 and 42 to thereby couple the expansion instrument 210 to the frame 26. As shown, each dove-tailed member 266 includes a pair of transversely opposed protrusions 280 that each define an angled engagement surface 284 that is configured to abut or otherwise contact a respective angled engagement surface 186 of the slots 174 when the engagement members 262 are mated with the engagement members 170. It should be appreciated that the engagement members 262 can have other configurations as desired. For example, the engagement members 262 and the engagement members 170 can be reversed.

As shown in FIG. 6D, a proximal end of each engagement member 262 defines a tapered lead-in portion 270 that allows the engagement members 262 to easily be guided into the openings 178 of the engagement members 170. Therefore, the expansion instrument 210 can easily be coupled to the frame 26 along a direction that is opposite the insertion direction I. That is, if the frame 26 is stationary, the expansion instrument 210 can be coupled to the frame 26 by translating the instrument 210 along a direction that is opposite the insertion direction I.

As shown in FIG. 6C, each gripping member 254 includes a pair of stops 300 that extend proximally toward the extension member 250 and are spaced apart from the extension member 250. As the gripping member 254 rotates about the second pivot 258 the stops 300 will limit the rotation by contacting the extension member 250. Therefore, the angular range in which the gripping members 254 can rotate about the second pivots 258 will depend on the distance in which the stops 300 are spaced apart from the extension members 250.

As shown in FIG. 6C, each gripping portion 236 further includes a biasing member 304 that is configured to bias the gripping members 254 toward each other. In the illustrated embodiment, the biasing members 304 are leaf springs 308 that are coupled to the extension members 250 and urge against an outer surface of the gripping members 304. By biasing the gripping members 254 toward each other, the expansion instrument 210 can more easily and more predictably be coupled to the frame 26. It should be appreciated, however, that the biasing members 304 can have other configurations as desired.

In operation and in reference to FIG. 6E, the expansion instrument 210 is coupled to the frame 26 by placing the engagement members 262 of the instrument 210 distal to the engagement members 170 of the frame 26. By translating or otherwise moving the frame 26 or the instrument 210 toward the other, the engagement members 262 will engage the engagement members 170 to thereby couple the frame 26 to the instrument 210 such that the second pivots 258 of the instrument 210 abut an outer surface of the flexible arms 38 and 42 proximate to the support member 34. By squeezing the handle portions 232 toward each other, the extension member 250 of the first expansion arm 220 will rotate counterclockwise about the first pivot 228 and the gripping member 254 of the first expansion arm 220 will rotate clockwise about the second pivot 258. Conversely, the extension member 250 of the second expansion arm 224 will rotate clockwise about the first pivot 228 and the gripping member 254 of the second expansion arm 224 will rotate counterclockwise about the second pivot 258.

This rotation will cause at least one of the first and second arms 38 and 42 to elastically flex away from the other. For example, the first and second inner spacer contacting surfaces 88 and 92 of the first and second arms 38 and 42 can define respective first and second respective contact locations 320 and 324, and at least one of the first and second arms 38 and 42 is flexible so as to be movable between a first position, whereby the frame 26 defines a first distance d1 that extends along the lateral direction A between the first and second contact locations 320 and 324, and a second position, whereby the frame 26 defines a second distance d2 that extends along the lateral direction A between the first and second contact locations 320 and 324. It should be appreciated that the first and second contact locations 320 and 324 can be located anywhere along the arms 320 and 324 so long as they remain the same when the first and second distances are measured.

As shown in FIG. 6E, the second distance d2 is greater than the first distance d1 such that when in the second position, the void 94 defines a cross-sectional dimension that is greater than that of the spacer body 30 such that the void 94 is sized to receive the spacer body 30. While the arms 38 and 42 are elastically flexed, at least one of the arms 38 and 42 is biased toward the first position. Therefore, when the handle portions 232 of the instrument 210 are released, the arms 38 and 42 will flex back to a third position, and when in the third position, the frame 26 defines a third distance d3 that extends along the lateral direction A between the first and second contact locations 320 and 324 and is less than the second distance d2 (See FIG. 2B). When in the third position at least one of the first and second inner contacting surfaces 88 and 92 of the arms 38 and 42 will apply a retention force against the spacer body 30 along a direction toward the other of the first and second inner spacer contacting surfaces 88 and 92.

In another embodiment and in reference to FIGS. 7A-7C, an intervertebral implant system 350 can include an intervertebral implant frame 426, and an actuation instrument 428 that is also configured as an expansion instrument. The frame 426 includes a support member 434, a first arm 438 that extends from the support member 434, and a second arm 442 that extends from the support member 434. The first and second arms 438 and 442 are flexible arms and are configured to elastically flex away from each other so that the frame 426 can receive a spacer body 30. The support member 434, the first arm 438, and the second arm 442 are similar to the support member 34, the first arm 38, and the second arm 42 shown in FIG. 3A, and include like structure unless otherwise described.

As shown in FIG. 7C, each of the first and second arms 438 and 442 includes a straight portion 446 and a bent portion 450 that extends from a distal end of the straight portion 446 at angle toward the other of the bent portions 450. Each arm 438 and 442 further includes an engagement member 454 that defines a slot 458 that extends through the respective arm 438 and 442. As shown the slots 458 extend through the straight portions 446 at substantially the same angle in which the bent portions 450 extend from the distal end of the straight portions 446. Moreover, the slots 458 extend through the straight portions 446 and into a cavity 460 defined by the bent portions 450. Each bent portion 450 further includes a retention bump 461. The bumps 461 are configured to provide a tactile feedback indicating that the expansion instrument 428 is coupled to the arms 438 and 442.

As shown in FIGS. 7A-7C, the expansion instrument 428 can include a pair of removable clips 470 that are configured to engage the slots 458 defined by the arms 438 and 442 by translating the clips 470 distally or along a direction that has a directional component that is the same as the insertion direction I. As shown, each clip 470 can be a substantially straight elongate member 474 having an engagement member 476 that is defined by a pair of elongate cantilevered beams 478 at its distal end that are separated by a recess 482. An outer beam 478 can include a recess 479 that is configured to receive the retention bump 461 and provide an indication that the clips 470 are properly coupled to the arms 438 and 442. As shown in FIG. 7B, each clip 470 can be attached to a respective arm 438 and 442 by inserting one of the cantilevered beams 478 of a respective clip 470 into a slot 458 of the respective arms 438 and 442. The cantilevered beam 478 that is inserted into the slot 458 will be received by the cavity 460 defined by the bent portion 450.

Once coupled to the arms 438 and 442, the clips 470 extend out from the arms 438 and 442 at an angle such that the clips 470 diverge from each other as they extend proximally. By squeezing a proximal portion of the clips 470 toward each other, the cantilevered beams 478 apply an expansion force to the engagement members 454 or at least to the bent portions 450 such that the arms 438 and 442 elastically flex away from each other. While flexed, the frame 426 can receive the spacer body 30. By releasing the clips 470, the arms 438 and 442 will apply a retention force to the spacer body 30 to thereby retain the spacer body 30 in the frame 426.

In another embodiment and in reference to FIGS. 8A-8C, an intervertebral implant system 522 can include an intervertebral implant frame 526, and an actuation instrument 528 that is configured as an expansion instrument. The frame 526 includes a support member 534, a first arm 538 that extends from the support member 534, and a second arm 542 that extends from the support member 534. The first and second arms 538 and 542 flexible arms and are configured to elastically flex away from each other so that the frame 526 can receive a spacer body 30. The support member 534, the first arm 538, and the second arm 542 are similar to the support member 34, the first arm 38, and the second arm 42 shown in FIG. 3A, and include like structure unless otherwise described.

As shown in FIG. 8C, each of the first and second arms 538 and 542 includes a straight portion 546 and a bent portion 550 that extends from a distal end of the straight portion 546 at angle toward the other of the bent portions 550. Each arm 538 and 542 further includes an engagement member 554 that defines a slot 558 that extends through the respective arm 538 and 542. As shown the slots 558 extend through the bent portions 550 along a direction that is opposite the insertion direction I. Moreover, the slots 558 extend into a cavity 560 that is defined by each straight portion 546. Each straight portion 546 further includes a retention bump 561. The bumps 561 are configured to provide a tactile feedback indicating that the expansion instrument 528 is coupled to the arms 538 and 542.

As shown in FIGS. 8A-8C, the expansion instrument 528 can include a pair of removable clips 570 that are configured to engage the slots 558 defined by the arms 538 and 542 by translating the clips 570 proximally or along a direction that is opposite to the insertion direction I. As shown, each clip 570 includes a handle portion 574 and a gripping portion 578 that extends distally from the handle portion 574. Each gripping portion 578 includes a body 582 and an engagement member 584 that extends out from the body 582. As shown, each engagement member 584 defines a proximally extending protrusion 586 that is spaced from the 582 such that a recess 588 is defined between the protrusion 586 and body 582. Each gripping portion 578 further includes a shoulder 590 that extends out from the body 582 and is configured to abut the arms 538 and 542 proximate to the support member 526 when the clip 570 is coupled to the frame 526. Each clip 570 further includes a recess 579 that is configured to receive the retention bump 561 and provide an indication that the clips 570 are properly coupled to the arms 538 and 542. As shown in FIG. 8B, each clip 570 can be attached to a respective arm 538 and 542 by inserting the protrusion 586 of a respective clip 470 into a slot 558 of a respective arm 538 and 542. The protrusion 586 will be received by the cavity 560 defined by the straight portion 546.

Once coupled to the arms 538 and 542, the clips 570 extend out from the arms 538 and 542 such that the handle portions 574 are proximal to the front of the frame 526 and the shoulders 590 are abutting the arms 538 and 542 proximate to the support member 526 as shown in FIG. 8B. By squeezing the handle portions 574 toward each other, clips 570 rotate about the shoulders 590 and the protrusions 586 apply an expansion force to the engagement members 554 or to at least the straight portions 546 such that the arms 538 and 542 elastically flex away from each other. While flexed, the frame 526 can receive the spacer body 30. By releasing the clips 570, the arms 538 and 542 will apply a retention force to the spacer body 30 to thereby retain the spacer body 30 in the frame 526.

It should be appreciated that the engagement members of the frames 26, 426, and 526, and the engagement members of the instruments 210, 428, and 528 are interchangeable. Therefore, for example, frame 26 and instrument 210 can include any of the engagement members 170, 262, 454, 476, 554, and 584 so long as the engagement members of the frame 26 can mate with the engagement members of the instrument 210 to thereby releasably couple the frame 26 to the instrument 210.

As shown in FIGS. 9A and 9B, the actuation instrument can be incorporated into the frame such that the actuation instrument and the frame are a unitary part. In accordance with another embodiment and in reference to FIG. 9A, an intervertebral implant frame 626 can include a support member 634, a first arm 638 that extends from the support member 634, and a second arm 642 that extends from the support member 634. The first and second arms 638 and 642 are flexible arms and are configured to elastically flex away from each other so that the frame 626 can receive a spacer body 30. The support member 634, the first arm 638, and the second arm 642 are similar to the support member 34, the first arm 38, and the second arm 42 shown in FIG. 3A, and include like structure unless otherwise described.

As shown in FIG. 9A, each of the first and second arms 638 and 642 includes a straight portion 646 and a bent portion 650 that extends from a distal end of the straight portion 646 at angle toward the other of the bent portions 650. Each arm 638 and 642 further includes an expansion member 654 that extends out from the arm at angle. As shown, each expansion member 654 extends out from the proximal end of the bent portion 650 and includes a handle portion 660 that is spaced apart from the straight portion 646. By squeezing the handle portions 660 toward each other, the arms 638 and 642 will elastically flex away from each other so that the frame 626 can receive the spacer body 30. As shown in FIG. 9B, the expansion members 654 can extend proximally such that handle portions 660 are proximal to the arms 638 and 642 to thereby provide more lavage. Once the frame 626 has been coupled to the spacer body 30, the expansion members 654 can be broken off and removed from the frame 626.

In another embodiment the frame can be configured to have portions of the frame arms crimped toward the spacer body to thereby retain the spacer body. In such embodiments, the frame is capable of receiving the spacer body without flexing the arms of the frame away from each other. The spacer body will then be retained by the frame by crimping the arms toward the spacer body to thereby provide a retention force to the spacer body.

For example, in reference to FIGS. 10A and 10B, an intervertebral implant frame 726 includes a support member 734, a first arm 738 that extends from the support member 734, and a second arm 742 that extends from the support member 734. The first and second arms 734 and 738 are crimpable arms such that the frame 726 is configured to have a first initial position in which the spacer body 30 can be disposed between the arms 738 and 742, and a second crimped or engaged position in which the arms 738 and 742 are crimped toward each other to thereby apply a retention force to the spacer body 30. The support member 734, the first arm 738, and the second arm 742 are similar to the support member 34, the first arm 38, and the second arm 42 shown in FIG. 3A, and include like structure unless otherwise described.

The first and second arms 738 and 742 are configured to be crimped rather than flexed. As shown, the arms 738 and 742 include first and second inner spacer contacting surfaces 744 and 746, respectively that are configured to contact and retain the spacer body 30. That is, the inner surface of the support member 734, the first inner spacer contacting surface 744 and the second inner spacer contacting surface 746 together define a void 748 that is configured to receive the spacer body 30. Each arm 738 and 742 further includes a substantially straight portion 750 and a crimp member 752 that extends distally from the straight portion 748. As shown, the crimp members 752 are each coupled to the straight portions 750 by a hinge 756. In the illustrated embodiment, the hinges 756 define transverse bending grooves 758 formed in the inner spacer contacting surfaces 744 and 746.

In operation, the frame 726 can receive the spacer body 30 within the void 748 without expanding the arms 738 and 742 away from each other. Though it should be appreciated some expanding may occur. Once the spacer body 30 is properly positioned, the first crimp member 752 of the first arm 738 can be rotated about the first hinge 756 such that the first crimp member 752 is bent toward the second arm 742. Similarly, the second crimp member 752 of the second arm 742 can be rotated about the second hinge 756 such that the second crimp member 752 is bent toward the first arm 738. After the crimp members 752 have been crimped or otherwise bent, the arms 738 and 742 apply a retention force to the spacer body 30 to thereby retain the spacer body 30 to the frame 726. As shown, each arm 738 and 742 can further include a retention member 760 that extends from the first and second inner spacer contacting surfaces 744 and 746, respectively. The retention members 760 are configured to engage the spacer body 30 to thereby prevent migration of the spacer body 30 from the frame 726.

In another embodiment and in reference to FIGS. 11A and 11B, an intervertebral implant frame 826 can include more than two crimp members. As shown, the frame 826 includes a support member 834, a first arm 838 that extends from the support member 834, and a second arm 842 that extends from the support member 834. The first and second arms 838 and 842 are crimpable arms such that the frame 826 is configured to have a first initial position in which the spacer body 30 can be disposed between the arms 838 and 842, and a second crimped or engaged position in which the arms 838 and 842 are crimped toward each other to thereby apply a retention force to the spacer body 30. The support member 834, the first arm 838, and the second arm 842 are similar to the support member 34, the first arm 38, and the second arm 42 shown in FIG. 3A, and include like structure unless otherwise described.

The first and second arms 838 and 842 are configured to be crimped rather than flexed. As shown, the arms 838 and 842 include first and second inner spacer contacting surfaces 844 and 846, respectively that are configured to contact and retain the spacer body 30. That is, the inner surface of the support member 834, the first inner spacer contacting surface 844 and the second inner spacer contacting surface 846 together define a void 848 that is configured to receive the spacer body 30. Each arm 838 and 842 further includes a first crimp member 850 and a second crimp member 852 that extends distally from the first crimp member 850. In other words, the first arm 838 can include a first crimp member 850 and a third crimp member 852 of the frame 826, and the second arm 842 can include a second crimp member 850 and a fourth crimp member 852 of the frame 826. As shown, the first crimp member 850 and the second crimp member 850 are each coupled to the support member 834 by first and second hinges 856 respectively. Similarly, the third and fourth crimp members 852 are coupled to the first crimp members 850 by third and fourth hinges 860 respectively. In the illustrated embodiment, the hinges 856 and 860 define transverse bending grooves 864 formed in the outer surfaces of the first and second arms 838 and 842.

In operation, the frame 826 can receive the spacer body 30 within the void 848 without expanding the arms 838 and 842 away from each other. Though it should be appreciated some expanding may occur. Once the spacer body 30 is properly positioned, the first crimp member 850 and the second crimp member 852 of the first arm 838 can be rotated about the first and second hinges 856 and 860 respectively such that the crimp members 850 and 852 are bent toward the second arm 842. Similarly, the first crimp member 850 and the second crimp member 852 of the second arm 842 can be rotated about the first and second hinges 856 and 860 respectively such that the crimp members 850 and 852 are bent toward the first arm 838. After the crimp members 850 and 852 have been bent, the arms 838 and 842 apply a retention force to the spacer body 30 to thereby retain the spacer body 30 to the frame 826. As shown, each arm 838 and 842 can further include a retention member 868 that extends from the first and second inner spacer contacting surfaces 844 and 846, respectively. The retention members 868 are configured to engage the spacer body 30 to thereby prevent migration of the spacer body 30 from the frame 826.

In another embodiment and in reference to FIGS. 12A and 12B, an intervertebral implant frame 926 can include crimp members that define crimping tabs. As shown, the frame 926 includes a support member 934, a first arm 938 that extends from the support member 934, and a second arm 942 that extends from the support member 934. The first and second arms 938 and 942 are crimpable arms such that the frame 926 is configured to have a first initial position in which the spacer body 30 can be disposed between the arms 938 and 942, and a second crimped or engaged position in which the arms 938 and 942 are crimped toward each other to thereby apply a retention force to the spacer body 30. The support member 934, the first arm 938, and the second arm 942 are similar to the support member 34, the first arm 38, and the second arm 42 shown in FIG. 3A, and include like structure unless otherwise described.

The first and second arms 938 and 942 are configured to be crimped rather than flexed. As shown, the arms 938 and 942 include first and second inner spacer contacting surfaces 944 and 946, respectively that are configured to contact and retain the spacer body 30. That is, the inner surface of the support member 934, the first inner spacer contacting surface 944 and the second inner spacer contacting surface 946 together define a void 948 that is configured to receive the spacer body 30. Each arm 938 and 942 further includes a substantially straight portion 950, a bent portion 951 extending from a distal end of the straight portion 950, and a crimp member 952 that is formed in the straight and bent portion 950 and 951. As shown, the crimp members 952 each define a crimping tab 956 that is attached to one of the straight portion 950 or the bent portion 951 by a hinge 958. In the illustrated embodiment, a proximal edge of the crimping tab 956 is coupled to the straight portion 950 and defines the hinge 958. It should be appreciated, however, that an upper edge, a lower edge, or a distal edge of the crimping tabs 956 could define the hinges 958. As shown, each crimping tab 956 is disposed within a window defined by the respective arm.

In operation, the frame 926 can receive the spacer body 30 within the void 948 without expanding the arms 938 and 942 away from each other. Though it should be appreciated some expanding may occur. Once the spacer body 30 is properly positioned, the crimping tab 956 of the first arm 938 can be rotated about the hinge 958 such that the crimping tab 956 is bent toward the second arm 942. Similarly, the crimping tab 956 of the second arm 942 can be rotated about the hinge 958 such that the crimping tab 956 is bent toward the first arm 938. After the crimping tabs 956 have been bent, the frame is in the crimped or engaged position such that the arms 938 and 942 apply a retention force to the spacer body 30 to thereby retain the spacer body 30 to the frame 926. It should be appreciated that the first and second arms 938 and 942 can include any number of crimping tabs 956 as desired.

In another embodiment and in reference to FIGS. 13A and 13B, an intervertebral implant frame 1026 can include crimp members that define tabs disposed along upper and lower edges of the arms. As shown, the frame 1026 includes a support member 1034, a first arm 1038 that extends from the support member 1034, and a second arm 1042 that extends from the support member 1034. The first and second arms 1034 and 1038 are crimpable arms such that the frame 1026 is configured to have a first initial position in which the spacer body 30 can be disposed between the arms 1038 and 1042, and a second crimped or engaged position in which the arms 1038 and 1042 are crimped toward each other to thereby apply a retention force to the spacer body 30. The support member 1034, the first arm 1038, and the second arm 1042 are similar to the support member 34, the first arm 38, and the second arm 42 shown in FIG. 3A, and include like structure unless otherwise described.

The first and second arms 1038 and 1042 are configured to be crimped rather than flexed. As shown, the arms 1038 and 1042 include first and second inner spacer contacting surfaces 1044 and 1046, respectively that are configured to contact and retain the spacer body 30. That is, the inner surface of the support member 1034, the first inner spacer contacting surface 1044 and the second inner spacer contacting surface 1046 together define a void 1048 that is configured to receive the spacer body 30. Each arm 1038 and 1042 further includes a substantially straight portion 1050, a bent portion 1051 extending from a distal end of the straight portion 1050, and at least one, such as a plurality of crimp members 1052 that are formed in upper and lower edges of the arms 1038 and 1042. As shown, the crimp members 1052 each define a crimping tab 1056 that are each attached to the straight and bent portions 1050 and 1051 by respective horizontal hinges 1058.

In operation, the frame 1026 can receive the spacer body 30 within the void 1048 without expanding the arms 1038 and 1042 away from each other. Though it should be appreciated some expanding may occur. Once the spacer body 30 is properly positioned, the crimping tabs 1056 of the first arm 1038 can be rotated about the hinges 1058 such that the crimping tabs 1056 are bent toward the second arm 1042. Similarly, the crimping tabs 1056 of the second arm 1042 can be rotated about the hinges 1058 such that the crimping tabs 1056 are bent toward the first arm 1038. After the crimping tabs 1056 have been bent, the frame 1026 is in the crimped or engaged position such that the arms 1038 and 1042 apply a retention force to the spacer body 30 to thereby retain the spacer body 30 to the frame 1026. It should be appreciated that the first and second arms 1038 and 1042 can include any number of crimping tabs 1056 as desired.

As shown in FIGS. 14A-14C, the spacer body 30 can be coupled to the frame 726 using an actuation instrument 1110 that is configured as a crimping instrument. The instrument 1110 and the frame 726 can together define an intervertebral implant system 1114. The crimping instrument 1110 includes an actuation grip 1116 that is configured as a crimping grip so as to apply a crimping force to the frame 726. For instance, in accordance with the illustrated embodiment, the crimping grip 1116 is configured to apply first and second crimping forces to the crimp members 752 of the first and second arms 738 and 742. The first and second crimping forces will permanently deform the crimp members 752 of the frame 726 to thereby retain the spacer body 30 to the frame 726. Therefore, the instrument 1110 is configured to have a first position or configuration whereby the instrument receives the frame 726, and a second position or configuration whereby the instrument applies a crimping force to the frame 726. It should be appreciated that the instrument 1110 can also be used to crimp the frame 726 to the spacer body.

As shown in FIGS. 14A and 14B, the instrument 1110 includes a first arm 1118 and a second arm 1122 rotatably coupled to the first arm 1118 at a first pivot 1126. The first and second arms 1118 and 1122 are configured as crimping arms and each includes a handle portion 1130 that extends proximally of the first pivot 1126 and a gripping portion 1134 that extends distally of the first pivot 1126. The handle portions 1130 are configured to be gripped by an individual and moved toward each other to thereby crimp the frame 726 to the spacer body 30.

As shown in FIGS. 14A and 14B, the gripping portions 1134 are coupled to the handle portions 1130 at respective second pivots 1138 that are distal to the first pivot 1126. As shown in FIG. 14B, each gripping portion 1134 includes an extension member 1142 that extends from the second pivot 1138, and a gripping member 1146 that extends distally from a distal end of the extension member 1142. As shown, the gripping portions 1134 are coupled to each other at a third pivot 1150 that proximate to the distal ends of the extension members 1142, such that the gripping members 1146 extend distally to the third pivot 1150. Therefore, when the handle portions 1130 are moved toward each other so as to rotate about the first pivot 1126, the extension members 1142 will rotate about their respective second pivots 1138 such that they move away from each other, and the gripping members 1146 will rotate about the third pivot 1150 such that they move toward each other to thereby crimp the frame 726 on to the spacer body 30.

As shown in FIG. 14B, each gripping member 1146 defines a ribbed contact surface 1156 that is configured to contact and apply a crimping force to the crimp members 752 of the frame 726. As shown, the contact surfaces 1156 are spaced apart from each other so as to define a void 1160 that is configured to receive the frame 726 and spacer body 30. Each gripping member 1146 may further define a lower platform that is configured to support the frame 726 and spacer body 30 while the instrument 1110 is crimping the frame 726 to the spacer body 30. The ribs of the contact surfaces 1156 are configured to allow a portion of the frame 26 between the gripping members 1146.

In operation and in reference to FIG. 14C, the void 1160 defined between the contact surfaces 1156 receives the frame 726 and spacer body 30 such that the spacer body 30 is loosely disposed within the frame 726. By squeezing the handle portions 1130 toward each other, the contact surfaces 1156 will apply respective crimping forces to the crimp members 752 of the frame 726. Once a sufficient amount of force has been applied, the crimp members 752 will permanently deform toward each other such that the frame 726 will move to the crimped or engaged position and will provide a retention force against the spacer body 30 and retain the spacer body 30 to the frame 726. As shown, when in the crimped or engaged position, respective portions of the arms 738 and 742 are spaced apart from each other by the second distance d2 which is less than the first distance.

In another embodiment and in reference to FIG. 14D, the instrument 1110 can also be configured to bend the crimp members 952 of the frame 926. As shown, the instrument 1110 can include beaked protrusions 1170 that are defined by the gripping members 1146 and are configured to engage the crimp members 952 when the handle portions 1130 are squeezed together. The beaked protrusions 1170 can be anywhere along the gripping members 1146 so long as they align with the crimp members 952. Moreover, the gripping members 1146 can define any number of beaked protrusions 1170, as desired. Therefore, if the frame 926 includes four crimping tabs 956 (i.e. crimp members 952) then the gripping members 1146 can each define two beaked protrusions 1170 that align with the crimping tabs 956.

In another embodiment and in reference to FIGS. 15A and 15B frame may include a fully enclosed endplate that supports the spacer body with a multi-walled, such as a six walled structure. As shown, an intervertebral implant frame 1226 includes a support member 1234, a first arm 1238 that extends from the support member 1234, a second arm 1242 that extends from the support member 1234, and an end plate 1244 that connects the distal ends of the first and second arms 1238 and 1242 together. The support member 1234, the first arm 1238, the second arm 1242, and the end plate 1244 together define a six wall structure that supports the spacer body 30.

Now in reference to FIGS. 16A-16E, the spacer body 30 can be pre-drilled to make channels in the spacer body 30 using a spacer body drill guide 1300. The channels are configured to provide clearance for the fixation elements 62 when the intervertebral implant is affixed to the superior and inferior vertebral bodies. Therefore, when the fixation elements are inserted into the fixation element apertures of the frame and then subsequently affixed to the vertebral bodies, the fixation elements will not be interfered with by the spacer body 30. The channels can be made either before or after the spacer body has been retained by the frame. If the channels are made prior to the spacer body being retained by the frame, then the channels can have a dimension that is greater than a dimension of the fixation element receiving apertures of the frame.

As shown in FIGS. 16A and 16B, the spacer body drill guide 1300 includes a clamp 1304 configured to hold the spacer body 30, and a cradle 1308 that is configured to support the clamp 1304 while the channels are drilled using a drill bit 1312. The clamp 1304 includes a first clamp arm assembly 1316 and a second clamp arm assembly 1320 that is rotatably coupled to the first clamp arm assembly 1316 at a first pivot 1324. The first clamp arm assembly 1316 includes a first handle 1328, a first extension member 1332, and a first jaw 1344 removeably coupled to the first extension member 1332. Similarly, the second clamp arm assembly 1320 includes a second handle 1352, a second extension member 1356, and a second jaw 1358 removeably coupled to the second extension member 1356. As shown, a proximal end of the first extension member 1332 is coupled to a middle portion of the first handle 1328 at a respective second pivot 1336, and a middle portion of the first extension member 1332 is coupled to a distal end of the second handle 1352 at the third pivot 1340. Similarly, a proximal end of the second extension member 1356 is coupled to a middle portion of the second handle 1352 at a respective second pivot 1336, and a middle portion of the second extension member 1356 is coupled to a distal end of the first handle 1352 at a respective third pivot 1340.

The first and second extension members 1332 and 1356 are substantially parallel to each other and remain substantially parallel to each other as the first and second handles 1328 and 1352 are rotated about the first pivot 1324. This allows the first and second jaws 1344 and 1358 to translate rather than rotate relative to each other as the first and second handles 1328 and 1352 are rotated about the first pivot 1324. As shown in FIGS. 16A and 16B, each extension member 1332 and 1356 includes an elongate mounting portion 1370 at its distal end. Each mounting portion 1370 defines a fixation element receiving aperture 1364 that is configured to receive a respective fixation element 1374. As shown, the first and second jaws 1344 and 1358 are configured to be mounted to the removeably mounting portions 1370 with the fixation elements 1374.

As shown in FIGS. 16A and 16B, the first jaw 1344 includes an elongate body 1380 that has a proximal mounting portion 1384 and a distal gripping portion 1388. The mounting portion 1384 defines an elongate channel 1392 that is configured to receive the mounting portion 1370 of the first extension member 1332. The mounting portion 1384 further defines an outer slot or aperture 1396 that extends into the channel 1392 and is configured to receive the fixation element 1374 to thereby couple the first jaw 1344 to the first extension member 1332. The mounting portion 1384 further includes an engagement rail 1397 that is configured to engage the cradle 1308 when the clamp 1304 is mounted to the cradle 1308.

As shown in FIGS. 16A and 16B, the gripping portion 1388 includes an inner spacer contacting surface 1402, an outer surface 1406 and at least one such as two, guide holes 1410 that extend from the outer surface 1406 through to the inner spacer contacting surface 1402 at a downward angle. The guide holes 1410 are configured to receive the drill bit 1312 and guide the drill bit 1312 to the spacer body 30. As shown, a lower portion of the inner spacer contacting surface 1402 defines a pair of cut outs 1412 that provide clearance for the drill bit 1312 as it extends thought the holes 1410.

As shown in FIG. 16B, the gripping portion 1388 can further include a mating member 1414, such as a bore 1418 that extends into the gripping portion 1388. The bore 1418 is configured to receive a mating member of the cradle 1308 to thereby properly align the clamp within the cradle. It should be appreciated that the mating member 1414 can have other configurations as desired. For example, the mating member 1414 can define a peg or protrusion.

As shown in FIGS. 16A and 16B, the second jaw 1358 includes an elongate body 1430 that has a proximal mounting portion 1434 and a distal gripping portion 1438. The mounting portion 1434 defines an elongate channel 1442 that is configured to receive the mounting portion 1370 of the first extension member 1332. The mounting portion 1434 further defines an outer slot or aperture 1446 that extends into the channel 1442 and is configured to receive the fixation element 1374 to thereby couple the second jaw 1358 to the second extension member 1356.

As shown in FIGS. 6A and 6B, the gripping portion 1438 includes an inner spacer contacting surface 1452, an outer surface 1456 and at least one such as two, guide holes 1460 that extend from the outer surface 1456 through to the inner spacer contacting surface 1452 at a downward angle. The guide holes 1460 are configured to receive the drill bit 1312 and guide the drill bit 1312 to the spacer body 30. As shown, a lower portion of the inner spacer contacting surface 1402 defines a pair of cut outs 1462 that provide clearance for the drill bit 1312 as it extends thought the holes 1460.

As shown in FIG. 16B, each gripping portion 1388 and 1438 can further include a plurality of retention members 1470 that extend out from the inner spacer contacting surfaces 1402 and 1452. In the illustrated embodiment the retention members 1470 define spikes that are configured to engage the spacer body 30. It should be appreciated, however, that the retention members 1470 can include other configuration, or the gripping portions 1388 and 1438 can be void of retention members 1470.

As shown in FIG. 16A, the cradle 1308 includes a base 1480 and a mounting portion 1484 that extends up from the base 1480. The base 1480 is sized and configured to sit on a surface and support the clamp 1304 while the drill bit 1312 drills the channels into the spacer body 30. The mounting portion 1484 includes a transverse elongate body 1488 and a channel 1492 that extends transversely into the body 1488. The channel 1492 is configured to receive the first jaw 1344 along a transverse direction such that when the first jaw 1344 is received by the channel 1492 the first jaw 1344 is fully supported by the cradle 1308.

The mounting portion 1484 further includes a pair of drill guide apertures 1500 that extend through body 1488 and into the channel 1492. The drill guide apertures 1500 of the mounting portion 1484 are configured to align with the drill guide apertures 1410 of the first jaw 1344 when the first jaw 1344 is received by the channel 1492. The mounting portion 1484 further includes a first platform 1504 that a distal end of the channel 1492 terminates into, and a mating member 1508 that is defined by the first platform 1504. In the illustrated embodiment, the mating member 1508 is a peg 1512 that is configured to mate with the bore 1418 of the first jaw 1344. It should be appreciated, however, that the mating member 1508 can have other configurations as desired so long as the mating members of the mounting portion 1484 and the first jaw 1344 can mate with each other.

As shown in FIG. 16A, the cradle 1308 further includes a second platform 1516 that extends from the base 1480 and is spaced apart from the first platform 1504. The second platform 1516 defines a pair of cutouts 1520 that align with the drill guide apertures 1460 of the second jaw 1358 when the second jaw 1358 is resting on the second platform 1516.

In operation and in reference to FIGS. 16C-16F, the clamp 1304 is configured to hold a spacer body 30 by moving the handle portions 1328 and 1352 toward each other. The clamp 1304 is then translated toward the cradle 1308 subsequently along the transverse direction T such that the first jaw 1344 of the clamp 1304 is mounted within the channel 1492 of the cradle 1408. When mounted and as shown in FIG. 16D, the peg 1512 engages the bore 1418, and the first and second jaws 1344 and 1358 rest on the first and second platforms 1504 and 1516 respectively, such that the drill guide apertures 1410 of the first jaw 1344 are aligned with the drill guide apertures 1500 of the cradle 1308.

As shown in FIG. 16E, the drill bit 1312 may then be inserted into the drill guide apertures 1410 and 1460 to thereby form the channels in the spacer body 30. As shown in FIG. 16F, the spacer body 30 will have two upper channels 1600, and two lower channels 1614. After the channels have been formed, the spacer body 30 may be coupled to a frame such as one of the frames described, using any of the instruments described. When the spacer body 30 is retained by the frame the fixation element receiving apertures of the frame will align with the channels 1600 and 1614 of the spacer body 30. The channels 1600 and 1614 can have a dimension have a dimension such as a diameter d4 that is greater than the diameter of the fixation element receiving apertures of the frame. It should be appreciated, however, that the diameter d5 can be equal to or even less than the diameter of the fixation element receiving apertures of the frame, as desired.

It should be appreciated, that the drill guide 1300 can be part of a kit that also includes at least one of an intervertebral implant frame, an actuation instrument, and a drill bit. Moreover is should be appreciated, that the kit can also include the spacer body 30 and at least one fixation element 62.

It will be appreciated by those skilled in the art that changes could be made to the embodiments described above without departing from the broad inventive concept thereof. Furthermore, it should be appreciated that the structure, features, and methods as described above with respect to any of the embodiments described herein can be incorporated into any of the other embodiments described herein unless otherwise indicated. For example, the frame 26 can also include crimp members as shown in FIGS. 10A, 11A, 12A, and 13A. It is understood, therefore, that this invention is not limited to the particular embodiments disclosed, but it is intended to cover modifications within the spirit and scope of the present disclosure.

Citas de patentes
Patente citada Fecha de presentación Fecha de publicación Solicitante Título
US42483629 Nov 18891 Abr 1890 Nut-lock
US110510510 Feb 191228 Jul 1914William O'n ShermanSurgical appliance.
US120079730 Sep 191510 Oct 1916David BarbeNut-lock.
US215191925 Mar 193528 Mar 1939Illinois Tool WorksLocking device
US237288820 Abr 19443 Abr 1945Duggan James EdwardNut structure
US262114517 Ago 19499 Dic 1952Sano Machteld EBone mat compositions
US278282712 Jun 195326 Feb 1957Rosan JosephSnap ring connection between threaded fastener and locking collar
US29063111 Nov 195629 Sep 1959Illinois Tool WorksStud carried locking detents with means to hold the detents in lock position
US297236718 Jul 195721 Feb 1961United Carr Fastener CorpFastening device
US306225326 Ago 19586 Nov 1962Waldes Kohinoor IncBolt and shear sleeve with shear sleeve retracting means
US327224930 Jul 196413 Sep 1966Slater Steel Ind LtdLocking device for use on suspension clamps and the like
US335010320 Sep 196531 Oct 1967Ventura Tool CompanySeal ring holding device
US356107515 Jul 19699 Feb 1971Motorola IncThreaded fastener captivating device
US35798315 Mar 196925 May 1971Stevens Irving JBone implant
US370730310 Mar 197126 Dic 1972Petri Johnson IncMeans for securing an insert to a base piece
US381070315 Jun 197014 May 1974Pasbrig MReleasable joints with male and female elements
US38998973 Abr 197419 Ago 1975Ford Motor CoBy-pass suction throttling valve in a refrigeration system
US394567123 Oct 197423 Mar 1976Emhart CorporationSeal lock and the like incorporating permanently secured single engagement
US40179461 Mar 197619 Abr 1977Alta Engineering, Inc.Lock screw for rigging connector or the like
US405630111 Mar 19761 Nov 1977Norden AlexanderRetained screw assembly
US412313212 Sep 197731 Oct 1978Pye (Electronic Products Ltd.)Screw or nut and a captive washer
US413550615 Mar 197723 Ene 1979Ulrich Max BMethod of and device for pinning a fractured vertebra
US42781205 Oct 197814 Jul 1981Hi Shear CorporationSafety bolt
US428087513 Oct 197828 Jul 1981Kraftwerk Union AktiengesellschaftSafety device for preventing unscrewing of cylinder-head screws having an inner polygon, and plastic deformation tool for use with the device
US428537728 Feb 197825 Ago 1981Hi-Shear CorporationSafety bolt
US42889025 Oct 197915 Sep 1981Franz Louis JMethod of forming a notched edge lock screw
US429706311 Jun 197927 Oct 1981Hi Shear CorporationTelescoping self-retaining safety bolt assembly
US429990218 Jul 197810 Nov 1981Canon Kabushiki KaishaImage forming process and apparatus therefor
US438892122 May 198121 Jun 1983Institut Straumann AgDevice comprising a plate and screws for fastening a plate to a bone
US448457022 May 198127 Nov 1984Synthes Ltd.Device comprising an implant and screws for fastening said implant to a bone, and a device for connecting two separated pieces of bone
US448854319 Ene 198318 Dic 1984Tornier S.A. FranceDevice for osteosynthesis of fractures of the extremities of the femur
US450126921 Feb 198426 Feb 1985Washington State University Research Foundation, Inc.Process for fusing bone joints
US450384825 Mar 198212 Mar 1985Aesculap-Werke AktiengesellschaftOsteosynthesis plate
US45120386 Abr 198123 Abr 1985University Of Medicine And Dentistry Of New JerseyBio-absorbable composite tissue scaffold
US455389019 Oct 198319 Nov 1985Bulent GulistanCaptive panel screw
US45990867 Jun 19858 Jul 1986Doty James RSpine stabilization device and method
US462785329 May 19859 Dic 1986American Hospital Supply CorporationMethod of producing prostheses for replacement of articular cartilage and prostheses so produced
US46405243 Abr 19853 Feb 1987Marker InternationalSki binding with screw retaining construction
US464876815 May 198410 Mar 1987Hambric James CLocknut assembly for high-speed rotary components
US467847029 May 19857 Jul 1987American Hospital Supply CorporationBone-grafting material
US470837728 Nov 198624 Nov 1987Aeroquip CorporationContractible coupling
US471176027 Feb 19868 Dic 1987Westinghouse Electric Corp.Nuclear reactor incorporating locking device for threaded bolt connections
US471711514 Oct 19865 Ene 1988The United States Of America As Represented By The Secretary Of The ArmyAdjustable mold for fabricating bone replacements
US479333520 Ene 198727 Dic 1988Sulzer Brothers LimitedBone implant for fixing artificial tendons or ligaments with application and extraction means
US480429022 Ago 198614 Feb 1989Peter J. BalsellsLatching and sealing device
US481209424 Sep 198714 Mar 1989Maclean-Fogg CompanyLocking fastener assembly for threaded joint
US48586036 Jun 198822 Ago 1989Johnson & Johnson Orthopaedics, Inc.Bone pin
US49042614 Ago 198827 Feb 1990A. W. Showell (Surgicraft) LimitedSpinal implants
US493685126 Ago 198826 Jun 1990Colin Electronics Co., Ltd.Analytic bone implant
US495029613 Jun 198921 Ago 1990Mcintyre Jonathan LBone grafting units
US49559088 Jun 198811 Sep 1990Sulzer Brothers LimitedMetallic intervertebral prosthesis
US496174017 Oct 19889 Oct 1990Surgical Dynamics, Inc.V-thread fusion cage and method of fusing a bone joint
US497657624 Feb 198811 Dic 1990The Boeing CompanyCaptive self-locking mechanism
US497835023 Ene 199018 Dic 1990Jaquet Orthopedie S.A.Transcutaneous pin for fixation of a bone part or fragment
US499408423 Jun 198919 Feb 1991Brennan H GeorgeReconstructive surgery method and implant
US50107832 Jul 199030 Abr 1991Caterpillar Inc.Tappet retainer assembly
US501706930 Ago 198921 May 1991Northrop CorporationSleeve bolt
US502094912 Dic 19894 Jun 1991Davidson Eugene PControlled-torque fastener
US50263736 Nov 198925 Jun 1991Surgical Dynamics, Inc.Surgical method and apparatus for fusing adjacent bone structures
US503022029 Mar 19909 Jul 1991Advanced Spine Fixation Systems IncorporatedSpine fixation system
US505304929 May 19851 Oct 1991Baxter InternationalFlexible prostheses of predetermined shapes and process for making same
US506285016 Ene 19905 Nov 1991University Of FloridaAxially-fixed vertebral body prosthesis and method of fixation
US507143721 Nov 199010 Dic 1991Acromed CorporationArtificial disc
US50840513 Nov 198728 Ene 1992Toermaelae PerttiLayered surgical biocomposite material
US508566019 Nov 19904 Feb 1992Lin Kwan CInnovative locking plate system
US509615026 Oct 198717 Mar 1992Westwood Samuel MClamp device
US51084387 May 199028 Abr 1992Regen CorporationProsthetic intervertebral disc
US511235416 Nov 198912 May 1992Northwestern UniversityBone allograft material and method
US511823511 Feb 19912 Jun 1992Illinois Tool Works Inc.Washer with integral flap and fastening assembly combining fastener with such washer
US513942415 Dic 198918 Ago 1992Yli Urpo AnttiImplant for the replacement of a tooth or a part of the bone tissue
US514740424 Oct 199015 Sep 1992Downey Ernest LVertebra prosthesis
US518038124 Sep 199119 Ene 1993Aust Gilbert MAnterior lumbar/cervical bicortical compression plate
US519232722 Mar 19919 Mar 1993Brantigan John WSurgical prosthetic implant for vertebrae
US520754326 Jun 19924 May 1993Deutsche Aerospace Airbus GmbhConnecting device with a nut and bolt to prevent loosening and losing the nut
US521166414 Ene 199218 May 1993Forschungsinstitut, Davos Laboratorium Fur Experimentelle ChirugieShell structure for bone replacement
US52350346 May 199110 Ago 1993Phillips Petroleum CompanyTreatment of polyarylene sulfide/sulfone polymers with zinc compound and acidic solution
US52383426 Ene 199324 Ago 1993Monogram Aerospace Industries, Inc.Blind fastener with mechanical thread lock
US52756013 Sep 19914 Ene 1994Synthes (U.S.A)Self-locking resorbable screws and plates for internal fixation of bone fractures and tendon-to-bone attachment
US52812267 Mar 199025 Ene 1994Davydov Anatoly BMissing portion of a tubular bone
US52846554 Feb 19928 Feb 1994Osteotech, Inc.Swollen demineralized bone particles, flowable osteogenic composition containing same and use of the composition in the repair of osseous defects
US52903123 Sep 19911 Mar 1994AlphatecArtificial vertebral body
US529825417 Dic 199129 Mar 1994Osteotech, Inc.Shaped, swollen demineralized bone and its use in bone repair
US53040212 Oct 199219 Abr 1994British Aerospace Public Limited CompanyScrew threaded locking bolt assembly
US531447610 Sep 199324 May 1994Osteotech, Inc.Demineralized bone particles and flowable osteogenic composition containing same
US53144774 Mar 199124 May 1994J.B.S. Limited CompanyProsthesis for intervertebral discs and instruments for implanting it
US533053522 Abr 199319 Jul 1994Sulzer Brothers LimitedScrew-nut for screwing implants together
US534878830 Ene 199120 Sep 1994Interpore Orthopaedics, Inc.Mesh sheet with microscopic projections and holes
US53685937 Jul 199229 Nov 1994Stark; John G.Devices and methods for attachment of spine fixation devices
US538032316 Jun 199310 Ene 1995Advanced Spine Fixation Systems, Inc.Clamps for spinal fixation systems
US538558323 Sep 199331 Ene 1995SofamorImplant for an osteosynthesis device, particular for the spine
US539736412 Oct 199314 Mar 1995Danek Medical, Inc.Anterior interbody fusion device
US540539116 Feb 199311 Abr 1995Hednerson; Fraser C.Fusion stabilization chamber
US541134826 Oct 19932 May 1995Bal Seal Engineering Company, Inc.Spring mechanism to connect, lock and unlock, members
US542381725 Nov 199413 Jun 1995Lin; Chih-IIntervertebral fusing device
US542577220 Sep 199320 Jun 1995Brantigan; John W.Prosthetic implant for intervertebral spinal fusion
US543968421 Ene 19948 Ago 1995Osteotech, Inc.Shaped, swollen demineralized bone and its use in bone repair
US54586386 Nov 199217 Oct 1995Spine-Tech, Inc.Non-threaded spinal implant
US54586418 Sep 199317 Oct 1995Ramirez Jimenez; Juan J.Vertebral body prosthesis
US54586431 Feb 199417 Oct 1995Kyocera CorporationArtificial intervertebral disc
US547834230 Jun 199426 Dic 1995Spinetech, Inc.Reversible bone screw lock
US548774415 Abr 199430 Ene 1996Advanced Spine Fixation Systems, Inc.Closed connector for spinal fixation systems
US54893081 Sep 19946 Feb 1996Spine-Tech, Inc.Spinal implant
US550781830 Jun 199416 Abr 1996Mclaughlin; John A.Multipolar joint endoprosthesis
US551418014 Ene 19947 May 1996Heggeness; Michael H.Prosthetic intervertebral devices
US552069013 Abr 199528 May 1996Errico; Joseph P.Anterior spinal polyaxial locking screw plate assembly
US55228997 Jun 19954 Jun 1996Sofamor Danek Properties, Inc.Artificial spinal fusion implants
US553174622 May 19952 Jul 1996Fastenetix, L.L.C.Posterior spinal polyaxial locking lateral mass screw plate assembly
US553403025 Abr 19949 Jul 1996Acromed CorporationSpine disc
US553403119 Sep 19949 Jul 1996Asahi Kogaku Kogyo Kabushiki KaishaProsthesis for spanning a space formed upon removal of an intervertebral disk
US55340327 Dic 19949 Jul 1996Zimmer, Inc.Orthopaedic implant assembly
US554584226 Oct 199313 Ago 1996Bal Seal Engineering Company, Inc.Radially mounted spring to connect, lock and unlock, and for snap-on fastening, and for mechanical, electromagnetic shielding, electrical conductivity, and thermal dissipation with environmental sealing
US554961222 Jun 199427 Ago 1996Codman & Shurtleff, Inc.Osteosynthesis plate system
US55496791 Mar 199527 Ago 1996Kuslich; Stephen D.Expandable fabric implant for stabilizing the spinal motion segment
US555419123 Ene 199510 Sep 1996BiomatIntersomatic vertebral cage
US55564306 Jun 199517 Sep 1996Gendler; ElFlexible membranes produced from organic bone matrix for skeletal repair and reconstruction
US55693086 Sep 199429 Oct 1996Sottosanti; John S.Methods for use in bone tissue regeneration
US557098327 Sep 19945 Nov 1996Hollander; Andrew A.Reduced-friction screw
US557119011 Ago 19945 Nov 1996Heinrich UlrichImplant for the replacement of vertebrae and/or stabilization and fixing of the spinal column
US55711923 Jul 19955 Nov 1996Heinrich UlrichProsthetic vertebral implant
US55780347 Jun 199526 Nov 1996Danek Medical, Inc.Apparatus for preventing screw backout in a bone plate fixation system
US559340917 Feb 199514 Ene 1997Sofamor Danek Group, Inc.Interbody spinal fusion implants
US559727824 Jul 199528 Ene 1997Maclean-Fogg CompanyLocking fastener assembly for threaded joint
US56015533 Oct 199411 Feb 1997Synthes (U.S.A.)Locking plate and bone screw
US56015543 Nov 199411 Feb 1997Advanced Spine Fixation Systems, Inc.Branch connector for spinal fixation systems
US56074281 May 19954 Mar 1997Lin; Kwan C.Orthopedic fixation device having a double-threaded screw
US560747420 Sep 19934 Mar 1997Board Of Regents, University Of Texas SystemMulti-phase bioerodible implant/carrier and method of manufacturing and using same
US56096357 Jun 199511 Mar 1997Michelson; Gary K.Lordotic interbody spinal fusion implants
US560963611 Ene 199611 Mar 1997Spine-Tech, Inc.Spinal implant
US560963717 Abr 199611 Mar 1997Biedermann; LutzSpace keeper, in particular for an intervertebral disk
US56161446 Jun 19951 Abr 1997Codman & Shurtleff, Inc.Osteosynthesis plate system
US56429602 Ago 19951 Jul 1997Arturo Salice S.P.A.Fastening element
US564560613 Ene 19958 Jul 1997Sulzer Medizinaltechnik AgOuter shell for an at least two-shell joint socket of a hip joint prosthesis
US56537089 Sep 19945 Ago 1997Advanced Spine Fixation Systems, Inc.Cervical spine rod fixation system
US567666621 Mar 199614 Oct 1997Spinetech, Inc.Cervical spine stabilization system
US56766997 May 199314 Oct 1997Laboratorium fur experimentalle Chirurgie, ForschungsinstitutBone regeneration membrane
US568131120 Dic 199528 Oct 1997Smith & Nephew, Inc.Osteosynthesis apparatus
US56832162 Feb 19954 Nov 1997General Electric CompanySpring latching mechanisms for preventing relative movement of assembled components
US568339429 Sep 19954 Nov 1997Advanced Spine Fixation Systems, Inc.Fusion mass constrainer
US568346327 Jul 19944 Nov 1997Advanced Technical FabricationIntersomatic vertebral column implant
US57024497 Jun 199530 Dic 1997Danek Medical, Inc.Reinforced porous spinal implants
US570245129 Dic 199530 Dic 1997Biedermann; LutzSpace holder, in particular for a vertebra or an intervertebral disk
US570245313 May 199630 Dic 1997Sofamor Danek GroupAdjustable vertebral body replacement
US57024553 Jul 199630 Dic 1997Saggar; RahulExpandable prosthesis for spinal fusion
US571389926 Abr 19963 Feb 1998Societe Jbs SaCervical cage designed for the performance of intersomatic arthrodesis
US571390031 May 19963 Feb 1998Acromed CorporationApparatus for retaining bone portions in a desired spatial relationship
US572558815 Abr 199610 Mar 1998Fastenetix, LlcAcetabular cup having polyaxial locking screws
US57281592 Ene 199717 Mar 1998Musculoskeletal Transplant FoundationSerrated bone graft
US573585316 Jun 19957 Abr 1998Olerud; SvenBone screw for osteosynthesis
US573590522 May 19967 Abr 1998Southwest Research InstituteShock absorbing element for a load bearing prosthesis
US57557966 Jun 199626 May 1998Ibo; IvoProsthesis of the cervical intervertebralis disk
US576625316 Ene 199616 Jun 1998Surgical Dynamics, Inc.Spinal fusion device
US577619425 Abr 19967 Jul 1998Nuvana Medical Innovations, LlcIntermedullary rod apparatus and methods of repairing proximal humerus fractures
US57761965 Mar 19967 Jul 1998Asahi Kogaku Kogyo Kabushiki KaishaProsthesis for spanning a space formed upon removal of an intervertebral disk
US577619711 Dic 19967 Jul 1998Sdgi Holdings, Inc.Adjustable vertebral body replacement
US577619810 Mar 19977 Jul 1998Sdgi Holdings, Inc.Adjustable vertebral body replacement
US57761992 May 19977 Jul 1998Sofamor Danek PropertiesArtificial spinal fusion implants
US577880417 Nov 199514 Jul 1998Read; Donald E.Fastening apparatus
US57829156 Ene 199721 Jul 1998Stone; Kevin R.Articular cartilage heterografts
US57857107 Jun 199528 Jul 1998Sofamor Danek Group, Inc.Interbody spinal fusion implants
US580043331 May 19961 Sep 1998Acromed CorporationSpinal column retaining apparatus
US58610417 Abr 199719 Ene 1999Arthit SitisoIntervertebral disk prosthesis and method of making the same
US58658455 Mar 19962 Feb 1999Thalgott; John S.Prosthetic intervertebral disc
US58658497 Jun 19952 Feb 1999Crosscart, Inc.Meniscal heterografts
US587640229 Mar 19962 Mar 1999Errico; Joseph P.Anterior spinal polyaxial locking screw plate assembly having recessed retaining rings
US587645230 May 19952 Mar 1999Board Of Regents, University Of Texas SystemBiodegradable implant
US58793891 Abr 19969 Mar 1999Koshino; TomihisaMedical substituting element for hard tissues and artificial joint
US588529914 Mar 199623 Mar 1999Surgical Dynamics, Inc.Apparatus and method for implant insertion
US58882229 Oct 199730 Mar 1999Sdgi Holding, Inc.Intervertebral spacers
US58882239 Jun 199830 Mar 1999Bray, Jr.; Robert S.Anterior stabilization device
US58882245 Sep 199730 Mar 1999Synthesis (U.S.A.)Implant for intervertebral space
US58882273 Oct 199630 Mar 1999Synthes (U.S.A.)Inter-vertebral implant
US58954266 Sep 199620 Abr 1999Osteotech, Inc.Fusion implant device and method of use
US589993921 Ene 19984 May 1999Osteotech, Inc.Bone-derived implant for load-supporting applications
US590230316 Ene 199811 May 1999Aesculap Ag & Co. KgPin-type holding element for an orthopaedic holding system
US590233815 Sep 199511 May 1999Crosscart, Inc.Anterior cruciate ligament heterograft
US590468310 Jul 199818 May 1999Sulzer Spine-Tech Inc.Anterior cervical vertebral stabilizing device
US590471924 Jul 199718 May 1999Techsys Medical, LlcInterbody fusion device having partial circular section cross-sectional segments
US591031518 Jul 19978 Jun 1999Stevenson; SharonAllograft tissue material for filling spinal fusion cages or related surgical spaces
US591175820 Jun 199615 Jun 1999Sulzer Orthopaedie AgTibia platform for a knee joint prosthesis and knee joint prosthesis with such a tibia platform
US592031231 Oct 19966 Jul 1999Ncr CorporationSystem and method for building testing and integrating a graphical dynakey user interface
US592202718 Dic 199713 Jul 1999Crosscart, Inc.Articular cartilage heterografts
US593183828 Ene 19983 Ago 1999Vito; Raymond P.Fixation assembly for orthopedic applications
US59447556 Mar 199831 Ago 1999Crosscart, Inc.Articular cartilage xenografts
US595155817 Sep 199814 Sep 1999Fiz; DanielBone fixation device
US595472229 Jul 199721 Sep 1999Depuy Acromed, Inc.Polyaxial locking plate
US59583146 Feb 199528 Sep 1999Draenert; KlausProcess for the preparation of porous material
US596809822 Oct 199619 Oct 1999Surgical Dynamics, Inc.Apparatus for fusing adjacent bone structures
US597236811 Jun 199726 Oct 1999Sdgi Holdings, Inc.Bone graft composites and spacers
US597614123 Feb 19952 Nov 1999Synthes (U.S.A.)Threaded insert for bone plate screw hole
US59761876 Oct 19972 Nov 1999Spinal Innovations, L.L.C.Fusion implant
US598052221 Nov 19979 Nov 1999Koros; TiborExpandable spinal implants
US598182824 Jul 19989 Nov 1999Board Of Trustees Of The University Of ArkansasComposite allograft, press, and methods
US598496719 Feb 199616 Nov 1999Sdgi Holdings, Inc.Osteogenic fusion devices
US59892899 Oct 199723 Nov 1999Sdgi Holdings, Inc.Bone grafts
US601385315 Feb 199411 Ene 2000The University Of Texas SystemContinuous release polymeric implant carrier
US60173459 May 199725 Ene 2000Spinal Innovations, L.L.C.Spinal fixation plate
US602553820 Nov 199815 Feb 2000Musculoskeletal Transplant FoundationCompound bone structure fabricated from allograft tissue
US60334053 Mar 19987 Mar 2000Surgical Dynamics, Inc.Apparatus and method for implant insertion
US60334383 Jun 19977 Mar 2000Sdgi Holdings, Inc.Open intervertebral spacer
US603976211 Jun 199721 Mar 2000Sdgi Holdings, Inc.Reinforced bone graft substitutes
US60455791 May 19974 Abr 2000Spinal Concepts, Inc.Adjustable height fusion device
US60455809 Oct 19984 Abr 2000Osteotech, Inc.Fusion implant device and method of use
US605674915 Mar 19992 May 2000Spineology, Inc.Method and device for fixing and correcting spondylolisthesis anteriorly
US60661759 Jun 199823 May 2000Henderson; Fraser C.Fusion stabilization chamber
US608015823 Ago 199927 Jun 2000Lin; Chih-IIntervertebral fusion device
US608019315 Sep 199827 Jun 2000Spinal Concepts, Inc.Adjustable height fusion device
US608659330 Jun 199811 Jul 2000Bonutti; Peter M.Method and apparatus for use in operating on a bone
US608661423 Ene 199811 Jul 2000Sulzer Orthopedics Inc.Orthopedic prosthesis having anti-backout screw
US609099827 Oct 199718 Jul 2000University Of FloridaSegmentally demineralized bone implant
US609608010 Feb 19991 Ago 2000Cortek, Inc.Apparatus for spinal fusion using implanted devices
US609608116 Ene 19971 Ago 2000University Of Florida Tissue Bank, Inc.Diaphysial cortical dowel
US609953120 Ago 19988 Ago 2000Bonutti; Peter M.Changing relationship between bones
US61104822 Jun 199529 Ago 2000Styker CorporationManufacture of autogenous replacement body parts
US611363722 Oct 19985 Sep 2000Sofamor Danek Holdings, Inc.Artificial intervertebral joint permitting translational and rotational motion
US611363826 Feb 19995 Sep 2000Williams; Lytton A.Method and apparatus for intervertebral implant anchorage
US61205035 Sep 199719 Sep 2000Michelson; Gary KarlinApparatus instrumentation, and method for spinal fixation
US61237316 Feb 199826 Sep 2000Osteotech, Inc.Osteoimplant and method for its manufacture
US612976312 Sep 199710 Oct 2000Chauvin; Jean-LucExpandable osteosynthesis cage
US613600131 Jul 199824 Oct 2000Michelson; Gary KarlinApparatus and method for linking spinal implants
US613955011 Feb 199831 Oct 2000Michelson; Gary K.Skeletal plating system
US614303026 Mar 19997 Nov 2000Bristol-Myers Squibb Co.Impaction allograft form and method of orthopaedic surgery using same
US614303323 Dic 19987 Nov 2000Synthes (Usa)Allogenic intervertebral implant
US615607026 Mar 19995 Dic 2000Howmedica Osteonics Corp.Allograft prosthetic joints and method
US619372111 Feb 199827 Feb 2001Gary K. MichelsonMulti-lock anterior cervical plating system
US619375626 Ago 199827 Feb 2001Sulzer Orthopaedie AgTubular support body for bridging two vertebrae
US619375729 Oct 199827 Feb 2001Sdgi Holdings, Inc.Expandable intervertebral spacers
US62003473 Ago 199913 Mar 2001LifenetComposite bone graft, method of making and using same
US620692228 Ene 199827 Mar 2001Sdgi Holdings, Inc.Methods and instruments for interbody fusion
US622460211 Oct 19991 May 2001Interpore Cross InternationalBone stabilization plate with a secured-locking mechanism for cervical fixation
US623161025 Ago 199915 May 2001Allegiance CorporationAnterior cervical column support device
US623503319 Abr 200022 May 2001Synthes (Usa)Bone fixation assembly
US623503423 Oct 199822 May 2001Robert S. BrayBone plate and bone screw guide mechanism
US62350592 Abr 199722 May 2001Scient'x (Societe A Responsabilite Limitee)Intersomatic setting and fusion system
US624173116 Abr 19995 Jun 2001Daniel FizPlate and screw assembly for fixing bones
US62417696 May 19985 Jun 2001Cortek, Inc.Implant for spinal fusion
US624510831 Ene 200012 Jun 2001SpinecoSpinal fusion implant
US625808919 May 199910 Jul 2001Alphatec Manufacturing, Inc.Anterior cervical plate and fixation system
US625812530 Jul 199910 Jul 2001Synthes (U.S.A.)Intervertebral allograft spacer
US62612918 Jul 199917 Jul 2001David J. TalaberOrthopedic implant assembly
US626158631 Ago 199917 Jul 2001Sdgi Holdings, Inc.Bone graft composites and spacers
US626469530 Sep 199924 Jul 2001Replication Medical, Inc.Spinal nucleus implant
US62705286 Ago 19997 Ago 2001Sdgi Holdings, Inc.Composited intervertebral bone spacers
US630613917 Mar 199923 Oct 2001Scint'xIntervertebral connection device with an anti-extraction device to prevent extraction of anchoring screws
US632256215 Dic 199927 Nov 2001Dietmar WolterFixation system for bones
US63311796 Ene 200018 Dic 2001Spinal Concepts, Inc.System and method for stabilizing the human spine with a bone plate
US634207424 Abr 200029 Ene 2002Nathan S. SimpsonAnterior lumbar interbody fusion implant and method for fusing adjacent vertebrae
US63648802 May 20002 Abr 2002Gary Karlin MichelsonSpinal implant with bone screws
US637198627 Oct 199816 Abr 2002George W. BagbySpinal fusion device, bone joining implant, and vertebral fusion implant
US637198818 Ene 200016 Abr 2002Sdgi Holdings, Inc.Bone grafts
US63719895 Jun 200016 Abr 2002Jean-Luc ChauvinMethod of providing proper vertebral spacing
US637568122 Jun 199923 Abr 2002Ebi, L.P.Vertebral body replacement
US638318626 Sep 20007 May 2002Gary K. MichelsonSingle-lock skeletal plating system
US638713014 Abr 200014 May 2002Nuvasive, Inc.Segmented linked intervertebral implant systems
US639503118 Oct 200028 May 2002Sdgi Holdings, Inc.Expandable intervertebral spacers
US63988111 Jun 20014 Jun 2002Sdgi Holdings, Inc.Composited intervertebral bone spacers
US641325914 Dic 20002 Jul 2002Blackstone Medical, IncBone plate assembly including a screw retaining member
US642306311 May 200023 Jul 2002Peter M. BonuttiChanging relationship between bones
US643210624 Nov 199913 Ago 2002Depuy Acromed, Inc.Anterior lumbar interbody fusion cage with locking plate
US64475126 Ene 200010 Sep 2002Spinal Concepts, Inc.Instrument and method for implanting an interbody fusion device
US644754611 Ago 200010 Sep 2002Dale G. BramletApparatus and method for fusing opposing spinal vertebrae
US64547714 Ene 200124 Sep 2002Gary K. MichelsonAnterior cervical plating system
US645815827 Oct 20001 Oct 2002LifenetComposite bone graft, method of making and using same
US646135910 Nov 19998 Oct 2002Clifford TribusSpine stabilization device
US646831122 Ene 200122 Oct 2002Sdgi Holdings, Inc.Modular interbody fusion implant
US64717245 Feb 200129 Oct 2002Sdgi Holdings, Inc.Methods and instruments for interbody fusion
US650325019 Abr 20017 Ene 2003Kamaljit S. PaulBone support assembly
US65243125 Ene 200125 Feb 2003Spinal Concepts, Inc.Instrument and method for implanting an interbody fusion device
US655838727 Abr 20016 May 2003Fastemetix, LlcPorous interbody fusion device having integrated polyaxial locking interference screws
US65584235 May 20006 May 2003Gary K. MichelsonInterbody spinal fusion implants with multi-lock for locking opposed screws
US655842428 Jun 20016 May 2003Depuy AcromedModular anatomic fusion device
US65620736 Feb 200113 May 2003Sdgi Holding, Inc.Spinal bone implant
US656920128 Sep 200127 May 2003Depuy Acromed, Inc.Hybrid composite interbody fusion device
US65759754 May 200110 Jun 2003Synthes (U.S.A.)Bone fixation method
US65760176 Feb 200110 Jun 2003Sdgi Holdings, Inc.Spinal implant with attached ligament and methods
US657929027 Nov 199817 Jun 2003Surgicraft LimitedSurgical implant and surgical fixing screw
US659262416 Nov 200015 Jul 2003Depuy Acromed, Inc.Prosthetic implant element
US660509025 Oct 200012 Ago 2003Sdgi Holdings, Inc.Non-metallic implant devices and intra-operative methods for assembly and fixation
US661667124 Sep 20019 Sep 2003Spinal Concepts, Inc.Instrument and method for implanting an interbody fusion device
US662016317 Jul 200016 Sep 2003Gary K. MichelsonAnterior cervical plating system and bone screw
US662348612 Sep 200023 Sep 2003Synthes (U.S.A.)bone plating system
US662999823 Ago 20007 Oct 2003Chih-I LinIntervertebral retrieval device
US663831012 Dic 200028 Oct 2003Osteotech, Inc.Intervertebral spacer and implant insertion instrumentation
US664521218 Oct 200211 Nov 2003Synthes (U.S.A.)Device for fixing implants on or in a bone
US665252520 Oct 200025 Nov 2003Sofamor S.N.C.Anterior implant for the spine
US665618120 Nov 20012 Dic 2003Robert A DixonMethod and device utilizing tapered screw shanks for spinal stabilization
US66798874 Jun 200120 Ene 2004Cortek, Inc.Surgical procedure for implanting spinal fusion device
US66825634 Mar 200227 Ene 2004Michael S. ScharfSpinal fixation device
US669584612 Mar 200224 Feb 2004Spinal Innovations, LlcBone plate and screw retaining mechanism
US66958517 Ago 200224 Feb 2004Sdgi Holdings, Inc.Methods and instruments for interbody fusion
US67060675 Nov 200116 Mar 2004Osteotech, Inc.Spinal intervertebral implant and method of making
US67094561 Oct 200123 Mar 2004Ev3 Santa Rosa, Inc.Percutaneous mitral annuloplasty with hemodynamic monitoring
US671281817 Jul 200030 Mar 2004Gary K. MichelsonMethod for connecting adjacent vertebral bodies of a human spine with a plating system
US673012710 Jul 20014 May 2004Gary K. MichelsonFlanged interbody spinal fusion implants
US673685028 Dic 200118 May 2004Spinal Concepts, Inc.Vertebral pseudo arthrosis device and method
US676173925 Nov 200213 Jul 2004Musculoskeletal Transplant FoundationCortical and cancellous allograft spacer
US677009627 Mar 20023 Ago 2004Spinevision S.A.Interbody spinal stabilization cage and spinal stabilization method
US678690924 Oct 20007 Sep 2004Sepitec FoundationImplant for osteosyntheses
US680009222 Ago 20005 Oct 2004Lytton A. WilliamsMethod and apparatus for intervertebral implant anchorage
US68057141 Abr 200219 Oct 2004Ulrich Gmbh & Co. KgAnchorable vertebral implant
US68085376 Jul 200126 Oct 2004Gary Karlin MichelsonExpandable implant with interlocking walls
US682456414 Jun 200230 Nov 2004Stryker France, SasTwo-part intersomatic implant
US683300623 May 200221 Dic 2004Sdgi Holdings, Inc.Expandable intervertebral spacers
US683790526 Sep 20024 Ene 2005Daniel M. LiebermanSpinal vertebral fusion implant and method
US68490938 Mar 20021 Feb 2005Gary K. MichelsonExpansion constraining member adapted for use with an expandable interbody spinal fusion implant and method for use thereof
US685516823 Abr 200215 Feb 2005Stryker FranceIntersomatic implants in two parts
US686367328 Ago 20038 Mar 2005Movdice Holding, Inc.Methods for adjustable bone fusion implants
US68729151 Mar 200129 Mar 2005Kabushiki Kaisha Yaskawa DenkiHigh speed carbon dioxide gas welding method
US688424225 Oct 200226 Abr 2005Society De Fabrication De Materiel Orthopedique, S.A.Anterior plating system and method
US689033410 Jun 200310 May 2005Synthes (U.S.A.)Bone fixation assembly
US689670116 Oct 200224 May 2005Sdgi Holdings, Inc.Modular interbody fusion implant
US68997352 Oct 200231 May 2005Sdgi Holdings, Inc.Modular intervertebral prosthesis system
US690257827 Oct 20007 Jun 2005LifenetComposite bone graft, method of making and using same
US691632024 Sep 200212 Jul 2005Gary K. MichelsonAnterior cervical plate system
US69237563 Jun 20012 Ago 2005Boris SudakovMultifunctional medical tool
US69534773 Mar 200411 Oct 2005Sdgi Holdings, Inc.Laterally expandable cage
US696260611 Dic 20018 Nov 2005Gary Karlin MichelsonExpandable push-in interbody spinal fusion implant
US696466419 Nov 200115 Nov 2005Spinal Concepts Inc.System and method for stabilizing the human spine with a bone plate
US69646877 Jul 200015 Nov 2005Scient'xAnatomical interbody implant and gripper for same
US697201923 Ene 20016 Dic 2005Michelson Gary KInterbody spinal implant with trailing end adapted to receive bone screws
US697203531 Dic 20026 Dic 2005Michelson Gary KExpandable threaded arcuate interbody spinal fusion implant with cylindrical configuration during insertion
US697447921 Abr 200313 Dic 2005Sdgi Holdings, Inc.System and method for blocking and/or retaining a prosthetic spinal implant
US698423421 Abr 200310 Ene 2006Rsb Spine LlcBone plate stabilization system and method for its use
US700138513 Ene 200421 Feb 2006Bonutti Ip, LlcJoint spacer with compartment for orthobiologic material
US700143213 Ene 200321 Feb 2006Cervitech, Inc.Intervertebral prosthesis
US701841619 Feb 200228 Mar 2006Zimmer Spine, Inc.Bone implants and methods
US703339423 May 200325 Abr 2006Sdgi Holdings, Inc.Interbody spinal fusion implants with end cap for locking vertebral body penetrating members
US70411355 Dic 20029 May 2006Sdgi Holdings, Inc.Interbody spinal fusion implants with single-lock for locking opposed screws
US704496814 Feb 200016 May 2006Musculoskeletal Transplant FoundationCompound bone structure of allograft tissue with threaded fasteners
US704497230 Jul 200316 May 2006Synthes Ag ChurBone implant, in particular, an inter-vertebral implant
US706009731 Mar 200313 Jun 2006Depuy Spine, Inc.Method and apparatus for implant stability
US706696112 Nov 200227 Jun 2006Gary Karlin MichelsonSpinal implant
US70778645 Feb 200318 Jul 2006Cross Medical Products, Inc.Vertebral interbody cage with translatable locking screw
US711222231 Mar 200326 Sep 2006Depuy Spine, Inc.Anterior lumbar interbody fusion cage with locking plate
US711222327 Dic 200226 Sep 2006Abbott Spine Inc.Pseudo arthrosis device
US713502426 Jun 200314 Nov 2006Cookgas, L.L.C.Lumbar spine fixation device
US713504319 Ago 200314 Nov 2006Showa Ika Kohgyo Co., Ltd.Intervertebral cage
US713798417 Sep 200321 Nov 2006Warsaw Orthopedic, Inc.Single-lock anterior cervical plate and method
US714766522 Jul 199912 Dic 2006Sdgi Holdings, Inc.Threaded cylindrical multidiscoid single or multiple array disc prosthesis
US71635614 May 200416 Ene 2007Warsaw Orthopedic, Inc.Flanged interbody spinal fusion implants
US71726273 Abr 20026 Feb 2007Scient'xStabilized interbody fusion system for vertebrae
US717267218 Nov 20056 Feb 2007Silverbrook Research Pty LtdMethod of adhesively binding a stack of sheets
US722645218 Feb 20045 Jun 2007Spinecore, Inc.Instrumentation and methods for use in implanting a cervical disc replacement device
US72264821 Sep 20045 Jun 2007Synthes (U.S.A.)Multipiece allograft implant
US723246323 Oct 200319 Jun 2007U.S. Spinal Technologies, LlcIntervertebral cage designs
US723246419 Ago 200419 Jun 2007Synthes (Usa)Intervertebral implant
US723820326 Sep 20023 Jul 2007Vita Special Purpose CorporationBioactive spinal implants and method of manufacture thereof
US725569811 Ago 200314 Ago 2007Warsaw Orthopedic, Inc.Apparatus and method for anterior spinal stabilization
US72760823 Sep 20042 Oct 2007Warsaw Orthopedic, Inc.Artificial spinal discs and associated implantation and revision methods
US732070813 Nov 200222 Ene 2008Sdgi Holdings, Inc.Cervical interbody device
US732301118 Oct 200229 Ene 2008Musculoskeletal Transplant FoundationCortical and cancellous allograft cervical fusion block
US744220930 Nov 200528 Oct 2008Warsaw Orthopedic, Inc.Implant with trailing end adapted to receive bone screws
US749123728 Mar 200517 Feb 2009Synthes Usa, LlcAllograft implant
US753426511 Abr 200019 May 2009Warsaw Orthopedic, Inc.Intervertebral spacers with side wall accessible interior cavity
US759493229 Dic 200529 Sep 2009International Spinal Innovations, LlcApparatus for anterior intervertebral spinal fixation and fusion
US76011737 May 200713 Oct 2009Synthes Usa, LlcMultipiece allograft implant
US760810726 Oct 200427 Oct 2009Warsaw Orthopedic, Inc.Expandable implant with interlocking walls and method for use thereof
US761845622 May 200717 Nov 2009Synthes Usa, LlcIntervertebral implant
US76219604 Mar 200524 Nov 2009Warsaw Orthopedic, Inc.Modular interbody fusion implant
US762538021 Jul 20041 Dic 2009Warsaw Orthopedic, Inc.Dual distractor inserter
US765504230 Nov 20042 Feb 2010Warsaw Orthopedic, Inc.Expandable intervertebral spacers
US770427923 Ago 200527 Abr 2010Moskowitz Mosheh TBi-directional fixating transvertebral body screws, zero-profile horizontal intervertebral miniplates, expansile intervertebral body fusion devices, and posterior motion-calibrating interarticulating joint stapling device for spinal fusion
US784618829 Sep 20067 Dic 2010Moskowitz Nathan CBi-directional fixating transvertebral body screws, zero-profile horizontal intervertebral miniplates, total intervertebral body fusion devices, and posterior motion-calibrating interarticulating joint stapling device for spinal fusion
US78462078 Ago 20057 Dic 2010Synthes Usa, LlcIntervertebral implant
US786261629 Abr 20094 Ene 2011Synthes Usa, LlcIntervertebral implant
US78750766 Oct 200925 Ene 2011Synthes Usa, LlcIntervertebral implant
US794290321 Ago 200717 May 2011Moskowitz Ahmnon DBi-directional fixating transvertebral body screws and posterior cervical and lumbar interarticulating joint calibrated stapling devices for spinal fusion
US799340314 Ene 20109 Ago 2011Warsaw Orthopedic, Inc.Expandable intervertebral spacers
US806230312 Ene 200722 Nov 2011K2M, Inc.Apparatus and methods for inserting an implant
US812870012 Sep 20076 Mar 2012Synthes Usa, LlcAllograft intervertebral implant and method of manufacturing the same
US818253230 Sep 200422 May 2012Lifenet HealthComposite bone graft, method of making and using same
US821114824 Abr 20073 Jul 2012Warsaw OrthopedicProstheses for locking an artificial disc in an intervertebral disc space
US82731276 Jun 200725 Sep 2012Spinesmith Partners, L.P.Interbody fusion device and associated methods
US830880416 Nov 200913 Nov 2012David KruegerSpinal fusion device
US83288722 Sep 200811 Dic 2012Globus Medical, Inc.Intervertebral fusion implant
US834322228 Abr 20061 Ene 2013Aiden CopeSpinal disc prosthesis and instruments
US835391311 Abr 201115 Ene 2013Moskowitz Ahmnon DBi-directional fixating transvertebral body screws and posterior cervical and lumbar interarticulating joint calibrated stapling devices for spinal fusion
US838276827 Sep 201126 Feb 2013K2M, Inc.Apparatus and methods for inserting an implant
US84256073 Abr 200723 Abr 2013Warsaw Orthopedic, Inc.Anchor member locking features
US846554616 Feb 200718 Jun 2013Ldr MedicalIntervertebral disc prosthesis insertion assemblies
US85407745 Nov 200824 Sep 2013DePuy Synthes Products, LLCLow profile intervertebral implant
US854556710 Ago 20111 Oct 2013David KruegerSpinal fusion device
US86417439 Jul 20134 Feb 2014Warsaw Orthopedic, Inc.Orthopedic implant with locking element
US86417681 Feb 20124 Feb 2014Globus Medical, Inc.Intervertebral fusion implant
US876483115 Dic 20101 Jul 2014DePuy Synthes Products, LLCIntervertebral implant
US900529527 Ago 201214 Abr 2015DePuy Synthes Products, LLCLow profile intervertebral implant
US200100011295 Dic 200010 May 2001Mckay William F.Osteogenic fusion device
US200100057965 Feb 200128 Jun 2001Thomas ZdeblickMethods and instruments for interbody fusion
US200100100212 Feb 200126 Jul 2001Boyd Lawrence M.Flexible implant using partially demineralized bone
US2001001677725 Abr 200123 Ago 2001SpinecoSpinal fusion implant
US2001002018622 Dic 20006 Sep 2001Boyce Todd M.Keyed intervertebral dowel
US2001003125412 Feb 200118 Oct 2001Bianchi John R.Assembled implant
US2001003945622 Mar 20018 Nov 2001Boyer Michael L.Tissue forms
US2001004194122 Mar 200115 Nov 2001Boyer Michael L.Multipiece implants formed of bone material
US2002000468310 Jul 200110 Ene 2002Michelson Gary K.Flanged interbody spinal fusion implants
US200200105116 Jul 200124 Ene 2002Michelson Gary KarlinExpandable implant with interlocking walls
US200200165952 Oct 20017 Feb 2002Gary K. MichelsonScrews of cortical bone and method of manufacture thereof
US200200228432 Oct 200121 Feb 2002Michelson Gary K.Screws of cortical bone and method of manufacture thereof
US2002002908422 Mar 20017 Mar 2002Paul David C.Bone implants with central chambers
US2002006551719 Abr 200130 May 2002Paul Kamaljit S.Bone support assembly
US2002008259724 Nov 199927 Jun 2002Robert FraserAnterior lumbar interbody fusion cage with locking plate
US2002008260320 Nov 200127 Jun 2002Dixon Robert A.Method and device utilizing tapered screw shanks for spinal stabilization
US200200914475 Nov 200111 Jul 2002Osteotech, Inc.Spinal intervertebral implant and method of making
US2002009515515 Mar 200218 Jul 2002Michelson Gary KarlinSpinal implant containing bone morphogenetic protein
US2002009937623 Ene 200125 Jul 2002Michelson Gary K.Interbody spinal implant with trailing end adapted to receive bone screws
US2002009937825 Mar 200225 Jul 2002Michelson Gary KarlinApparatus, instrumentation and method for spinal fixation
US2002010639327 Ago 20018 Ago 2002Bianchi John R.Assembled implant, including mixed-composition segment
US2002011168015 Nov 200115 Ago 2002Michelson Gary K.Ratcheted bone dowel
US200201287128 Mar 200212 Sep 2002Michelson Gary K.Expansion constraining member adapted for use with an expandable interbody spinal fusion implant
US200201287179 Mar 200112 Sep 2002Alfaro Arthur A.Anterior lumbar spacer
US200201474506 Nov 200110 Oct 2002Lehuec Jean-CharlesAnterior plating system and method
US2002016950825 Mar 200214 Nov 2002Pioneer Laboratories, Inc.Spinal fixation system
US200201938805 Ago 200219 Dic 2002Robert FraserAnterior lumbar interbody fusion cage with locking plate
US20020995155 Título no disponible
US2003004593923 Ago 20026 Mar 2003Simon CasuttArtificial intervertebral disc
US200300786669 Nov 200124 Abr 2003Ralph James D.Intervertebral spacer device having a slotted partial circular domed arch strip spring
US200300786685 Dic 200224 Abr 2003Michelson Gary K.Interbody spinal fusion implants with single-lock for locking opposed screws
US2003012573926 Sep 20023 Jul 2003Bagga Charanpreet S.Bioactive spinal implants and method of manufacture thereof
US2003013527725 Nov 200217 Jul 2003Sdgi Holdings, Inc.Implantable joint prosthesis and associated instrumentation
US200301539755 Feb 200314 Ago 2003Byrd John AbbottVertebral Interbody cage with translatable locking screw
US2003016709224 Mar 20034 Sep 2003Foley Kevin T.Spinal bone implant
US2003019562618 May 200116 Oct 2003Jean HuppertIntersomatic cage with unified grafts
US2003019563218 Abr 200316 Oct 2003Foley Kevin T.Spinal implant with attached ligament
US2003019998323 May 200323 Oct 2003Michelson Gary K.Interbody spinal fusion implants with end cap for locking vertebral body penetrating members
US2004007807818 Oct 200222 Abr 2004Shepard Yolanda DeniseCortical and cancellous allograft cervical fusion block
US200400780819 Sep 200322 Abr 2004Ferree Bret A.Bioresorbable components and methods for spinal arthroplasty
US20040092929 *27 Sep 200213 May 2004Zindrick Michael R.Spinal plate with means to secure a graft
US200400930846 Nov 200313 May 2004Michelson Gary K.Method for inserting and deploying an expandable interbody spinal fusion implant
US2004010284821 Nov 200327 May 2004Michelson Gary K.Expandable interbody spinal fusion implant with expansion constraining member and method for use thereof
US2004012640723 Oct 20031 Jul 2004Falahee Mark H.Intervertebral cage designs
US2004013327831 Oct 20038 Jul 2004Marino James F.Spinal disc implant
US2004014327014 Oct 200322 Jul 2004St. Francis Medical Technologies, Inc.Tools for implanting artificial vertebral disk and method
US200401768535 Mar 20039 Sep 2004Sennett Andrew R.Apparatus and method for spinal fusion using posteriorly implanted devices
US2004019925412 Jul 20027 Oct 2004Christian LouisVertebral cage device with modular fixation
US2004021021921 Abr 200321 Oct 2004Bray Robert S.Bone plate stabilization system and method for its use
US2004021031021 Abr 200321 Oct 2004Trieu Hai H.Implant system and method for intervertebral disc augmentation
US200402103144 May 200421 Oct 2004Michelson Gary K.Flanged interbody spinal fusion implants
US2004024937712 Jul 20029 Dic 2004Kaes David R.Intervertebral implant with movement resistant structure
US2004025464421 Oct 200316 Dic 2004Taylor Brett AllisonIntervertebral disk prosthesis
US200500151494 Ago 200420 Ene 2005Michelson Gary K.Instrumentation with inwardly moveable extensions for inserting an expandable interbody spinal fusion implant
US2005002114322 Jul 200327 Ene 2005Cervitech, Inc.Intervertebral disc prosthesis
US200500334333 Sep 200410 Feb 2005Michelson Gary K.Implant having upper and lower extended members and method for use thereof
US200500495933 Sep 20033 Mar 2005Duong Lan Anh NguyenBone plate with captive clips
US200500495952 Sep 20043 Mar 2005Suh Sean S.Track-plate carriage system
US20050065605 *18 Sep 200324 Mar 2005Jackson Roger P.Threaded center line cage with funnel shaped profile
US2005006560724 Sep 200324 Mar 2005Gross Jeffrey M.Assembled fusion implant
US200500656084 Nov 200424 Mar 2005Michelson Gary K.Expandable threaded arcuate interbody spinal fusion implant with lordotic configuration during insertion
US200500710082 Jun 200431 Mar 2005Kirschman David LouisSpinal fusion system and method for fusing spinal bones
US20050085913 *27 Ago 200421 Abr 2005Robert FraserSpinal fixation plate
US200501019603 Abr 200112 May 2005Vincent FiereStabilised interbody fusion system for vertebrae
US2005014919319 Nov 20047 Jul 2005St. Francis Medical Technology, Inc.Intervertebral body fusion cage with keels and implantation methods
US2005015439129 Dic 200414 Jul 2005Thomas DohertyBone anchor assemblies
US2005015981315 Ene 200421 Jul 2005Molz Fred J.IvSpinal implant construct and method for implantation
US2005015981817 Dic 200421 Jul 2005Jason BlainTotal disc replacement system and related methods
US2005015981918 Ene 200521 Jul 2005Sdgi Holdings, Inc.Adjustable drill guide
US2005017160724 Mar 20054 Ago 2005Michelson Gary K.Manufactured bone composite implant shaped to conform to a prepared implantation space
US2005017723619 Ago 200411 Ago 2005Claude MathieuIntervertebral implant
US2005024026728 Mar 200527 Oct 2005Randall Brandon LAllograft implant
US200502402719 May 200527 Oct 2005Spinecore, Inc.Cervical disc replacement
US2005026176730 Sep 200424 Nov 2005LifenetComposite bone graft, method of making and using same
US2006002034220 Jul 200526 Ene 2006Ferree Bret AFacet-preserving artificial disc replacements
US2006003085112 Oct 20059 Feb 2006Rsb Spine LlcImplant subsidence control
US2006007990131 Ago 200513 Abr 2006Ryan Christopher JTranslatable carriage fixation system
US2006007996130 Nov 200513 Abr 2006Michelson Gary KImplant with trailing end adapted to receive bone screws
US200600850718 Ago 200520 Abr 2006Beat LechmannIntervertebral implant
US2006008971712 Ago 200527 Abr 2006Manoj KrishnaSpinal prosthesis and facet joint prosthesis
US2006012924010 Dic 200415 Jun 2006Joe LessarImplants based on engineered composite materials having enhanced imaging and wear resistance
US2006013606318 Abr 200522 Jun 2006Ldr MedicalIntervertebral disc prosthesis
US2006014276518 Abr 200329 Jun 2006Dixon Robert AVertebral implant for bone fixation or interbody use
US200601951894 Feb 200431 Ago 2006Cervitech, Inc.Prosthetic joint of cervical intervertebral for a cervical spine
US200602062089 May 200614 Sep 2006Sdgi Holdings, Inc.Push-in interbody spinal fusion implant with multi-lock for locking opposed screws and method for use thereof
US2006022972523 Ene 200612 Oct 2006Beat LechmannIntervertebral implant comprising dome-shaped joint surfaces
US2007008844121 Sep 200619 Abr 2007Synergy Disc Replacement, Inc.Artificial Spinal Disc
US2007009381925 Ago 200626 Abr 2007Albert Todd JBone screw apparatus, system and method
US200701063845 Ene 200710 May 2007Rsb Spine LlcImplant subsidence control
US2007011812524 Oct 200524 May 2007Orbay Jorge LBone fixation system and bone screws having anti-back out feature
US200701239872 Nov 200631 May 2007Bernstein Avi JCurvilinear cervical interbody device
US2007016213024 Feb 200612 Jul 2007Ralph RashbaumIntervertebral disc prosthesis and instrumentation for insertion of the prosthesis between the vertebrae
US2007016803213 Ene 200619 Jul 2007Nabil L. Muhanna, M.D.Flexible vertebral implant
US2007021963522 May 200720 Sep 2007Claude MathieuIntervertebral implant
US2007022580624 Mar 200627 Sep 2007Sdgi Holdings, Inc.Arthroplasty device
US2007022581226 Oct 200427 Sep 2007Gill Steven SIntervertebral Prosthesis
US2007025016716 Abr 200725 Oct 2007Rsb Spine LlcSpine implants
US2007027096125 Abr 200622 Nov 2007Sdgi Holdings, Inc.Spinal implant with deployable and retractable barbs
US2008003344021 Ago 20077 Feb 2008Moskowitz Ahmnon DBi-directional fixating transvertebral body screws and posterior cervical and lumbar interarticulating joint calibrated stapling devices for spinal fusion
US2008005189011 Ago 200628 Feb 2008Warsaw Orthopedic, Inc.Intervertebral Implants with Attachable Flanges and Methods of Use
US2008008216928 Sep 20063 Abr 2008Gittings Darin CTool systems for implanting prosthetic intervertebral discs
US2008011993317 Dic 200222 May 2008Mathys Medizinaltechnik AgIntervertebral Implant Comprising Joint Parts That Are Mounted To Form A Universal Joint
US2008013301330 Jun 20055 Jun 2008Synergy Disc Replacement, Inc.Artificial Spinal Disc
US200801619254 Oct 20063 Jul 2008Seaspine, Inc.Articulating spinal implant
US2008017730724 Mar 200824 Jul 2008Moskowitz Ahmnon DBi-directional fixating/locking transvertebral body screw/intervertebral cage stand-alone constructs and posterior cervical and lumbar interarticulating joint stapling guns and devices for spinal fusion
US2008020098416 Feb 200721 Ago 2008Ldr MedicalIntervertebral Disc Prosthesis Insertion Assemblies
US200802495693 Abr 20079 Oct 2008Warsaw Orthopedic, Inc.Implant Face Plates
US200802495753 Abr 20079 Oct 2008Warsaw Orthopedic, Inc.Anchor Member Locking Features
US20080249625 *3 Abr 20079 Oct 2008Warsaw Orthopedic, Inc.Composite Interbody Spacer
US20080269806 *24 Abr 200730 Oct 2008Jeffrey ZhangProstheses for locking an artificial disc in an intervertebral disc space
US2008027545512 Ene 20076 Nov 2008Amicus, LlcApparatus and Methods for Inserting an Implant
US200803065966 Jun 200711 Dic 2008Jones Robert JInterbody fusion device and associated methods
US2009007660817 Sep 200719 Mar 2009Vermillion Technologies, LlcIntervertebral disc replacement prosthesis
US2009010583023 Ene 200823 Abr 2009Jones Robert JInterbody fusion device, integral retention device, and associated methods
US2009019261330 Mar 200930 Jul 2009Aesculap Implant Systems, Inc.Standalone dynamic interbody
US2009021006220 Feb 200820 Ago 2009John ThalgottOrthopaedic Implants and Prostheses
US2009021006429 Abr 200920 Ago 2009Beat LechmannIntervertebral implant
US20090234455 *22 May 200917 Sep 2009Moskowitz Ahmnon DBi-directional fixating/locking transvertebral body screw/intervertebral cage stand-alone constructs having a central screw locking lever, and pliers and devices for spinal fusion
US2009032658025 Jun 200831 Dic 2009Anderson Mark ESpinal fixation device
US2010001690116 Jun 200621 Ene 2010Robinson James CBone screw retaining system
US2010012533416 Nov 200920 May 2010David KruegerSpinal fusion device
US201001454596 Nov 200910 Jun 2010Mcdonough William PZero-profile interbody spacer and coupled plate assembly
US201001454606 Nov 200910 Jun 2010Mcdonough William PZero-profile interbody spacer and coupled plate assembly
US2011011884324 Ene 201119 May 2011Claude MathieuIntervertebral implant
US2011029537116 May 20111 Dic 2011Moskowitz Ahmnon DBi-directional fixating transvertebral body screws and posterior cervical and lumbar interarticulating joint calibrated stapling devices for spinal fusion
US2012010158128 Oct 201126 Abr 2012Claude MathieuIntervertebral implant
US2012010930928 Oct 20113 May 2012Claude MathieuIntervertebral implant
US2012010931028 Oct 20113 May 2012Claude MathieuIntervertebral Implant
US2012010931128 Oct 20113 May 2012Claude MathieuIntervertebral Implant
US2012010931228 Oct 20113 May 2012Claude MathieuIntervertebral implant
US2012010931328 Oct 20113 May 2012Claude MathieuIntervertebral Implant
US2012017925921 Dic 201112 Jul 2012Mcdonough William PIntervertebral implants, systems, and methods of use
US201300730466 Oct 201121 Mar 2013Jillian ZaveloffMulti-piece Intervertebral Implants
US2013007304727 Jul 201221 Mar 2013Daniel LaskowitzMulti-piece Intervertebral Implants
US2013016603214 Feb 201327 Jun 2013William P. McDonoughIntervertebral implants, systems, and methods of use
US201301730134 Oct 20124 Jul 2013Lifenet HealthComposite Bone Graft, Method of Making and Using the Same
US2013026800823 May 201310 Oct 2013William P. McDonoughZero-Profile Interbody Spacer and Coupled Plate Assembly
US201400251685 Mar 201323 Ene 2014Jennifer KlimekMulti-Piece Intervertebral Implants
US2014012177720 Nov 20131 May 2014Kyle RosenMulti-Piece Intervertebral Implants
US2014018042226 Feb 201426 Jun 2014Globus Medical, Inc.Low Profile Plate
US201402574875 Mar 201311 Sep 2014Globus Medical, Inc.Low Profile Plate
US2014033677025 Jul 201413 Nov 2014Globus Medical, IncLow Profile Plate
US2014037185930 Jun 201418 Dic 2014Globus Medical, IncLow Profile Plate
AU2004232317B2 Título no disponible
CA2317791A126 Ene 19995 Ago 1999Sdgi Holdings, Inc.Methods and instruments for interbody fusion
DE2821678C318 May 19788 Ene 1981Gebrueder Sulzer Ag, Winterthur (Schweiz)Título no disponible
DE3042003A17 Nov 198015 Jul 1982Hans Dr ReimerBone cement reinforcing component - comprises thread structure compatible with body tissue forming soft sponge
DE3933459A16 Oct 198918 Abr 1991Karsten Dipl Ing ReumannBiomedical implant production equipment - uses computer tomographic image to generate implant profile for component mfr.
DE4242889A118 Dic 199223 Jun 1994Merck Patent GmbhHohlendoprothesen mit Knochenwachstumsfördernder Füllung
DE4409392A118 Mar 199421 Sep 1995Biedermann Motech GmbhHöhenverstellbarer Wirbelkörper
DE4423257C22 Jul 199412 Jul 2001Ulrich HeinrichImplantat zum Einsetzen zwischen Wirbelkörper der Wirbelsäule als Platzhalter
DE29913200U128 Jul 199923 Sep 1999Tutogen Medical GmbhImplantat aus Knochenmaterial
DE202004020209U130 Dic 20044 May 2006Mathys Medizinaltechnik AgAiming device for surgical drills and introduction of bone fixing means has aiming body comprising positioning device arranged at front surfaces which are insertable in hole on an implant
DEI9504867C1 Título no disponible
EP0179695B125 Sep 198529 Mar 1989Pierre KehrVertebral prosthesis, in particular for cervical vertebrae
EP0505634A126 Abr 199130 Sep 1992Kyocera CorporationA prosthesis
EP0505634B126 Abr 199120 Ago 1997Kyocera CorporationA prosthesis
EP0517030A219 May 19929 Dic 1992MAN Ceramics GmbHVertebral implant
EP0517030A319 May 199214 Abr 1993Man Ceramics GmbhVertebral implant
EP0517030B119 May 19924 Sep 1996MAN Ceramics GmbHVertebral implant
EP0577178A118 Jun 19935 Ene 1994ESKA Implants GmbH & Co.An implant having an open-cell or open-pore metal structure
EP0639351A217 Jun 199422 Feb 1995ULRICH, HeinrichImplant for the replacement of a vertebra and/or stabilisation and fixation of the spinal column
EP0639351A317 Jun 199429 Mar 1995Ulrich HeinrichTítulo no disponible
EP0897697A18 May 199824 Feb 1999Spinal InnovationsSpinal fixation plate
EP0906065B123 Abr 19971 Sep 2004Nuvana Medical Innovations, L.L.C.Intermedullary rod apparatus for repairing proximal humerus fractures
EP0966930A123 Jun 199929 Dic 1999Biomet Merck LimitedVertebral body replacement
EP0968692A123 Jun 19995 Ene 2000Christos KalaitzisPlate-cylinder vertebral prosthesis system
EP0974319A221 Jul 199926 Ene 2000Howmedica GmbHA reconstruction system for vertebra
EP0974319A321 Jul 199917 Oct 2001Howmedica GmbHA reconstruction system for vertebra
EP1033941B127 Nov 19984 Ago 2004Surgicraft LimitedSurgical implant and surgical fixing screw
EP1051133B126 Ene 199927 Oct 2004SDGI Holdings, Inc.Interbody fusion apparatus
EP1103236B123 Nov 200023 Ago 2006DePuy Spine, Inc.Anterior lumbar interbody fusion cage with locking plate
EP1124512B127 Oct 199922 Sep 2004SDGI Holdings, Inc.Expandable intervertebral spacers
EP1194087B17 Jul 200027 Ago 2008Scient'xAnatomical interbody implant
EP1402836B111 Feb 199812 Jul 2006SDGI Holdings, Inc.Single-lock anterior cervical plate
EP1459711B127 Oct 19994 Jul 2007Warsaw Orthopedic, Inc.Expandable intervertebral spacers
FR2552659B3 Título no disponible
FR2697996B1 Título no disponible
FR2700947B1 Título no disponible
FR2727003B1 Título no disponible
FR2747034A1 Título no disponible
FR2753368B1 Título no disponible
GB157668A Título no disponible
GB265592A Título no disponible
GB2148122A Título no disponible
GB2207607B Título no disponible
GB2239482A Título no disponible
GB2266246A Título no disponible
JP2006513752T5 Título no disponible
JPH03505416A Título no disponible
JPH09280219A Título no disponible
RU2229271C1 Título no disponible
RU2244527C2 Título no disponible
RU2307625C1 Título no disponible
SU1465040A1 Título no disponible
WO1988003417A13 Nov 198719 May 1988Material Consultants OySurgical biocomposite material and a method for producing the material
WO1988010100A115 Jun 198829 Dic 1988Yli Urpo AnttiAn implant for the replacement of a tooth or a part of the bone tissue
WO1990000037A128 Jun 198911 Ene 1990Michelson Gary KArtificial spinal fusion implants
WO1992001428A124 Jul 19916 Feb 1992Mohamed Ibrahim RasheedArtificial vertebra
WO1992006005A13 Oct 199116 Abr 1992Canadian Space AgencyInterface for orbital replacement units
WO1995021053A16 Feb 199510 Ago 1995Klaus DraenertMaterial and process for producing the same
WO1996039988A36 Jun 199630 Ene 1997Michelson Gary KTranslateral spinal implant
WO1997020526A16 Dic 199612 Jun 1997Bray Robert S JrAnterior stabilization device
WO1997023175A119 Dic 19963 Jul 1997ColoradoInterbody vertebral implant
WO1997025941A116 Ene 199724 Jul 1997Osteotech, Inc.Process and apparatus for producing flexible sheets from demineralized, elongate, bone particles
WO1997025945A116 Ene 199724 Jul 1997University Of Florida, Tissue Bank, Inc.Diaphysial cortical dowel
WO1997039693A123 Abr 199730 Oct 1997Nuvana Medical Innovations, L.L.C.Intermedullary rod apparatus and methods of repairing proximal humerus fractures
WO1998017209A321 Oct 199711 Sep 1998Sdgi Holdings IncSpinal spacer
WO1998055052A13 Jun 199810 Dic 1998Sdgi Holdings, Inc.Open intervertebral spacer
WO1998056319A111 Jun 199817 Dic 1998Sdgi Holdings, Inc.Reinforced bone graft sustitutes
WO1998056433A111 Jun 199817 Dic 1998Sdgi Holdings, Inc.Bone graft composites and spacers
WO1999009903A127 Ago 19974 Mar 1999Synthes Ag ChurLocking ring with bayonet for plate osteosynthesis
WO1999027864A327 Nov 19982 Sep 1999Philip Hobson HardcastleSurgical implant and surgical fixing screw
WO1999029271A110 Dic 199817 Jun 1999Sdgi Holdings, Inc.Osteogenic fusion device
WO1999032055A123 Dic 19981 Jul 1999Depuy Acromed, Inc.Spacer assembly for use in spinal surgeries
WO1999038461A322 Ene 19994 Nov 1999Synthes AgAllogenic intervertebral implant
WO1999038463A226 Ene 19995 Ago 1999Sdgi Holdings, Inc.Methods and instruments for interbody fusion
WO1999056675A129 Abr 199911 Nov 1999Sdgi Holdings, Inc.Adjustable vertebral body replacement
WO1999063914A18 Jun 199916 Dic 1999Henderson Fraser CFusion stabilization chamber
WO2000007527A130 Jul 199917 Feb 2000Synthes Ag ChurIntervertebral allograft spacer
WO2000007528A16 Ago 199917 Feb 2000Sdgi Holdings, Inc.Composited intervertebral bone spacers
WO2000025706A127 Oct 199911 May 2000Sdgi Holdings, Inc.Expandable intervertebral spacers
WO2000030568A119 Nov 19992 Jun 2000Musculoskeletal Transplant Foundation Edison Corporate CenterCompound bone structure fabricated from allograft tissue
WO2000040177A118 Dic 199913 Jul 2000LifenetComposite bone graft, method of making and using same
WO2000041654B111 Ene 20007 Feb 2002Lawrence M BoydTruncated open intervertebral spacers
WO2000059412A14 Abr 200012 Oct 2000Raymedica, Inc.Prosthetic spinal disc nucleus having a shape change characteristic
WO2000066044A15 May 20009 Nov 2000Michelson Gary KNested interbody spinal fusion implants
WO2000066045A15 May 20009 Nov 2000Michelson Gary KSpinal fusion implants with opposed locking screws
WO2000074607A18 Jun 200014 Dic 2000Osteotech, Inc.Keyed intervertebral dowel
WO2001008611A121 Jun 20008 Feb 2001Tutogen Medical GmbhImplant from osseous material
WO2001056497A25 Feb 20019 Ago 2001Michelson Gary KExpandable interbody spinal fusion implant
WO2001056497A35 Feb 200113 Dic 2001Gary K MichelsonExpandable interbody spinal fusion implant
WO2001056497B15 Feb 20017 Mar 2002Gary K MichelsonExpandable interbody spinal fusion implant
WO2001062190A122 Feb 200130 Ago 2001Stryker Spine SaIntervertebral implant with rigid body and support surfaces
WO2001080785A124 Abr 20011 Nov 2001Simpson Nathan SAnterior lumbar interbody fusion implant
WO2001093742A23 Jun 200113 Dic 2001Boris SudakovMultifunctional medical tool
WO2001093742A33 Jun 200112 Sep 2002Boris SudakovMultifunctional medical tool
WO2001095837A111 Jun 200120 Dic 2001Michelson Gary KManufactured major long bone ring implant shaped to conform to a prepared intervertebral implantation space
WO2004069106A16 Feb 200319 Ago 2004Synthes Ag ChurIntervertebral implant
WO2005007040A Título no disponible
WO2005020861A12 Sep 200410 Mar 2005Hfsc CompanyMultipiece allograft implant
WO2006138500A316 Jun 20068 Feb 2007James C RobinsonBone screw retaining system
WO2007098288A227 Feb 200730 Ago 2007Synthes (U.S.A.)Intervertebral implant with fixation geometry
WO2008014258A324 Jul 200719 Jun 2008Spine Solutions IncIntervertebral implant with keel
WO2008082473A113 Dic 200710 Jul 2008Owens Corning Intellectual Capital, LlcVeneer panel
WO2008124355A131 Mar 200816 Oct 2008Warsaw Orthopedic, Inc.Implant face plates
WO2008154326A16 Jun 200818 Dic 2008Spinesmith L.P.Interbody fusion device, integral retention device, and associated methods
WO2009064644A15 Nov 200822 May 2009Synthes(U.S.A.)Low profile intervertebral implant
WO2010054181A16 Nov 200914 May 2010Synthes Usa, LlcVertebral interbody spacer and coupled plate assembly
WO2010054208A16 Nov 200914 May 2010Synthes Usa, LlcVertebral interbody spacer and coupled plate assembly
WO2012088238A221 Dic 201128 Jun 2012Synthes Usa, LlcIntervertebral implants, systems, and methods of use
Otras citas
Referencia
1Appendix 1 to Joint Claim Construction Brief; Synthes' Exhibits A-9, In the United States District Court for the District of Delaware Civil Action No. 1:11-cv-00652-LPS, Jun. 8, 2012, 192 pages.
2Appendix 2 to Joint Claim Construction Brief; Globus' Exhibits A-F, In the United States District Court for the District of Delaware Civil Action No. 1:11-cv-00652-LPS, Jun. 8, 2012, 146 pages.
3Appendix 3 to Joint Claim Construction Brief; Exhibits A-C, In the United States District Court for the District of Delaware Civil Action No. 1:11-cv-00652-LPS, Jun. 8, 2012, 38 pages.
4Bray, "InterPlate Spine Fusion Device: Subsidence Control Without Stress Shielding", Orthopaedic Product News, Sep./Oct. 2006, pp. 22-25.
5Chadwick et al., "Radiolucent Structural Materials for Medical Applications," www.mddionline.com/print/238, Jun. 1, 2001, accessed date Jul. 31, 2012, 9 pages.
6Expert Report of Dr. Domagoj Carle Regarding the Invalidity of U.S. Patent Nos. 7,846,207, 7,862,616 and 7,875,076, In the United States District Court for the District of Delaware, Civil Action No. 1:11-cv-00652-LPS, Nov. 5, 2012, 149 pages.
7Expert Report of John F. Hall, M.D., United States District Court for the District of Delaware, Civil Action No. 1:11-cv-00652-LPS, Dec. 14, 2012, 27 pages.
8Expert Report of Paul Ducheyne, Ph.D. Concerning Patent Validity, United States District Court District of Delaware, Civil Action No. 1:11-cv-00652-LPS, Dec. 13, 2012, 155 pages.
9Expert Report of Richard J. Gering, Ph.D., CLP In the United States District Court for the District of Delaware, Civil Action No. 1:11-cv-00652-LPS, Dec. 14, 2012, 39 pages.
10International Patent Application No. PCT/CH2003/00089, International Search Report dated Dec. 2, 2003, 3 pgs.
11International Patent Application No. PCT/US2011/066421; International Search Report and Written Opinion dated Jun. 14, 2012, 31 pages.
12International Patent Application PCT/US2011/066421, International Search Report dated Jun. 14, 2012, 31 pages.
13International Search Report, completed Aug. 16, 2007 for International Application No. PCT/US2007/005098, filed Feb. 27, 2007.
14International Search Report, Mailed Mar. 20, 2009, for PCT International Application No. PCT/US80/82473, filed Nov. 5, 2008.
15Japanese Patent Application No. 2011-534926: Office Action dated Oct. 30, 2013, 7 pages.
16Japanese Patent Application No. 2011-534928: Office Action dated Sep. 30, 2013, 11 pages.
17Joint Claim Construction Brief, In the United States District Court for the District of Delaware, Civil Action No. 1:11-cv-00652-LPS, Jun. 14, 2012, 97 pages.
18Jonbergen et al., "Anterior CervicalInterbody fusion with a titanium box cage: Early radiological assessment of fusion and subsidence", The Spine Journal 5, Jul. 2005, 645-649.
19Jury Trial Demanded, In the United States District Court for the District of Delaware, Case No. 1:11-cv-00652-LPS, filed Jul. 22, 2011,8 pages.
20Jury Verdict Form, United States District Court District of Delaware, Civil Action No. 1:11-cv-00652-LPS, Jun. 14, 2013, 20 pages.
21Marcolongo et al., "Trends in Materials for Spine Surgery", Biomaterials and Clinical Use, 6, 2011, 21 pages.
22Memorandum Opinion, United States District Court District of Delaware, Civil Action No. 1:11-cv-00652-LPS, May 7, 2013, 33 pages.
23Order, United States District Court District of Delaware, Civil Action No. 1:11-cv-00652-LPS, May 15, 2013, 4 pages.
24Order, United States District Court District of Delaware, Civil Action No. 1:11-cv-00652-LPS, May 7, 2013, 7 pages.
25Parlov et al., "Anterior Lumbar Interbody Fusion with Threaded Fusion Cages and Autologous Grafts", Eur. Spine J., 2000, 9, 224-229.
26Plaintiffs' Responses and Objections to Defendant Globus Medical, Inc.'s First Set of Interrogatories (Nos. 1-11), United States District Court for the District of Delaware, Civil Action No. 1:11-cv-00652-LPS, Nov. 14, 2011, 18 pages.
27Plaintiffs' Supplemental Responses and Objections to Defendant Globus Medical Inc.'s Interrogatories Nos. 6-10 and Second Supplemental Responses and Objections to Interrogatory No. 5, United States District Court for the District of Delaware, Civil Action No. 11-cv-652-LPS, Sep. 1, 2012, 12 pages.
28Redacted version of "Defendant Globus Medical, Inc.'s Answering Brief in Opposition to Plaintiff's Motion for Summary Judgment of No Anticipation by the Kozak and Michelson References", Mar. 12, 2013, 233 pages.
29Redacted version of "Opening Brief in Support of Plaintiffs' Motion for Summary Judgment of No Anticipation by the Kozak and Michelson References", United States District Court District of Delaware, Civil Action No. 1:11-cv-00652-LPS, Feb. 13, 2013, 66 pages.
30Redacted version of "Plaintiff's Reply Brief in Support of Plaintiff's Motion for Summary Judgment of No Anticipation by the Kozak and Michelson References", Mar. 21, 2013, 11 pages.
31Reply Report of Dr. Domagoj Carle Regarding the Invalidity of U.S. Patent Nos. 7,846,207, 7,862,616 and 7,875,076, In the United States District Court for the District of Delaware, Civil Action No. 1:11-cv-00652-LPS, Jan. 4, 2013, 81 pages.
32Russian Patent Application No. 2011-1122797: Decision to Grant dated Oct. 9, 2013, 20 pages.
33Schleicher et al., "Biomechanical Comparison of Two Different Concepts for Stand-alone anterior lumbar interbody fusion", Eur. Spine J., Sep. 2008, 17, 1757-1765.
34Scholz et al., "A New Stand-Alone Cervical Anterior Interbody Fusion Device", Spine, Jan. 2009, 34(2), 6 pages.
35Second Expert Report of Wilson C. Hayes, Ph.D., United States District Court for the District of Delaware, Civil Action No. 1:11-cv-00652-LPS, Dec. 14, 2012, 22 pages.
36Spruit et al., "The in Vitro Stabilizing Effect of Polyether-etherketone Cages Versus a Titanium Cage of similar design for anterior lumbar interbody fusion", Eur. Spine J., Aug. 2005, 14 752-758.
37Synthes Spine, "CorticoCancellous ACF Spacer. An allograft space or anterior fusion of the cervical spine," brochure, Musculoskeletal Transplant Foundationm, 2003, 6 pages.
38Synthes Spine, "SynFix-LR System. Instruments and Implants for Stand-Alone Anterior Lumbar Interbody Fusion (ALIF)", Technique Guide dated 2008, pp. 2-40, Published by Synthes Spine (USA).
39Synthes Spine, "Zero-P Instruments and Implants. Zero-Profile Anterior Cervical Interbody Fusion (ACIF) device", Technique Guide dated 2008, pp. 2-32, Published by Synthes Spine (USA).
40Trial Transcript, United States District Court District of Delaware, Civil Action No. 1:11-cv-00652-LPS, Jun. 10, 2013, 114 pages.
41Trial Transcript, United States District Court District of Delaware, Civil Action No. 1:11-cv-00652-LPS, Jun. 11, 2013, 98 pages.
42Trial Transcript, United States District Court District of Delaware, Civil Action No. 1:11-cv-00652-LPS, Jun. 12, 2013, 75 pages.
43Trial Transcript, United States District Court District of Delaware, Civil Action No. 1:11-cv-00652-LPS, Jun. 13, 2013, 94 pages.
44Trial Transcript, United States District Court District of Delaware, Civil Action No. 1:11-cv-00652-LPS, Jun. 14, 2013, 26 pages.
45Trial Transcript, United States District Court District of Delaware, Civil Action No. 1:11-cv-00652-LPS, Jun. 3, 2013, 98 pages.
46Trial Transcript, United States District Court District of Delaware, Civil Action No. 1:11-cv-00652-LPS, Jun. 4, 2013, 110 pages.
47Trial Transcript, United States District Court District of Delaware, Civil Action No. 1:11-cv-00652-LPS, Jun. 5, 2013, 99 pages.
48Trial Transcript, United States District Court District of Delaware, Civil Action No. 1:11-cv-00652-LPS, Jun. 6, 2013, 80 pages.
49Trial Transcript, United States District Court District of Delaware, Civil Action No. 1:11-cv-00652-LPS, Jun. 7, 2013, 97 pages.
50U.S. Appl. No. 11/199,599: Amendment/Request for Reconsideration after Non-Final Rejection, dated Sep. 29, 2009, 30 pages.
51U.S. Appl. No. 11/199,599: Appeal Brief, dated Apr. 15, 2010, 51 pages.
52U.S. Appl. No. 11/199,599: Final Rejection, dated Dec. 24, 2009, 21 pages.
53U.S. Appl. No. 11/199,599: Interview Summary included Draft Amendments, dated Sep. 24, 2009, 16 pages.
54U.S. Appl. No. 11/199,599: Non-Final Rejection, dated Apr. 1, 2009, 20 pages.
55U.S. Appl. No. 11/199,599: Preliminary Amendment, dated Jan. 9, 2008, 11 pages.
56U.S. Appl. No. 60/988,661, dated Nov. 16, 2007, Kueenzi et al.
57U.S. Appl. No. 61/535,726, filed Sep. 16, 2011, Zaveloff.
58Written Opinion, Mailed Mar. 20, 2009, for PCT International Application No. PCT/US08/82473, filed Nov. 5, 2008.
Eventos legales
FechaCódigoEventoDescripción
10 Jul 2012ASAssignment
Owner name: SYNTHES USA, LLC, PENNSYLVANIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:MCDONOUGH, WILLIAM P.;STRAUSBAUGH, WILLIAM L.;CHRONISTER, BENJAMIN;AND OTHERS;SIGNING DATES FROM 20120601 TO 20120621;REEL/FRAME:028520/0423
Owner name: SYNTHES GMBH, SWITZERLAND
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:KUEENZI, THOMAS;REEL/FRAME:028520/0359
Effective date: 20120620
Owner name: SYNTHES USA, LLC, PENNSYLVANIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:SYNTHES GMBH;REEL/FRAME:028520/0463
Effective date: 20120604
6 May 2013ASAssignment
Owner name: DEPUY SYNTHES PRODUCTS, LLC, MASSACHUSETTS
Free format text: CHANGE OF NAME;ASSIGNOR:HAND INNOVATIONS LLC;REEL/FRAME:030359/0036
Effective date: 20121231
Owner name: HAND INNOVATIONS LLC, FLORIDA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:DEPUY SPINE, LLC;REEL/FRAME:030359/0001
Effective date: 20121230
Owner name: DEPUY SPINE, LLC, MASSACHUSETTS
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:SYNTHES USA, LLC;REEL/FRAME:030358/0945
Effective date: 20121230
24 Feb 2015ASAssignment
Owner name: DEPUY SYNTHES PRODUCTS, INC., MASSACHUSETTS
Free format text: CHANGE OF NAME;ASSIGNOR:DEPUY SYNTHES PRODUCTS, LLC;REEL/FRAME:035074/0647
Effective date: 20141219
17 May 2017ASAssignment
Owner name: HAND INNOVATIONS LLC, FLORIDA
Free format text: CORRECTIVE ASSIGNMENT TO CORRECT THE INCORRECT APPL. NO. 13/486,591 PREVIOUSLY RECORDED AT REEL: 030359 FRAME: 0001. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT;ASSIGNOR:DEPUY SPINE, LLC;REEL/FRAME:042621/0565
Effective date: 20121230
5 Jun 2017ASAssignment
Owner name: DEPUY SPINE, LLC, MASSACHUSETTS
Free format text: CORRECTIVE ASSIGNMENT TO CORRECT THE INCORRECT APPLICATION NO. US 13/486,591 PREVIOUSLY RECORDED ON REEL 030358 FRAME 0945. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT;ASSIGNOR:SYNTHES USA, LLC;REEL/FRAME:042687/0849
Effective date: 20121230