|Número de publicación||US9308328 B2|
|Tipo de publicación||Concesión|
|Número de solicitud||US 12/866,699|
|Número de PCT||PCT/JP2008/053603|
|Fecha de publicación||12 Abr 2016|
|Fecha de presentación||29 Feb 2008|
|Fecha de prioridad||29 Feb 2008|
|También publicado como||EP2246084A1, US20100318036, WO2009107224A1|
|Número de publicación||12866699, 866699, PCT/2008/53603, PCT/JP/2008/053603, PCT/JP/2008/53603, PCT/JP/8/053603, PCT/JP/8/53603, PCT/JP2008/053603, PCT/JP2008/53603, PCT/JP2008053603, PCT/JP200853603, PCT/JP8/053603, PCT/JP8/53603, PCT/JP8053603, PCT/JP853603, US 9308328 B2, US 9308328B2, US-B2-9308328, US9308328 B2, US9308328B2|
|Inventores||Hideaki Kawamura, Hiroshi Togashi|
|Cesionario original||Daikyo Seiko, Ltd|
|Exportar cita||BiBTeX, EndNote, RefMan|
|Citas de patentes (13), Otras citas (2), Clasificaciones (6), Eventos legales (1)|
|Enlaces externos: USPTO, Cesión de USPTO, Espacenet|
This application is a U.S. national phase filing under 35 U.S.C. §371 of PCT Application No. PCT/JP2008/053603, filed Feb. 29, 2008, which is hereby incorporated in its entirety by reference.
This invention relates to a plunger rod and a syringe, and more specifically, is concerned with a plunger rod for a syringe, said plunger rod being colored in part or in whole, and also with a high-identifiability syringe making use of the plunger rod.
An administration of a drug solution to a patient by a syringe is carried out by a procedure such as that to be described hereinafter. After the drug solution is first drawn from an ampoule or vial and filled in a syringe barrel by using a plunger rod, the plunger rod is slowly pushed into the syringe barrel so that the drug solution is injected directly or via an infusion tube into a blood vessel or the like of the patient. Syringes, which are used as described above, are substantially the same in configuration from the request for giving priority to their basic function, and even among those having syringe barrels different in thickness and/or length because of differences in capacity, they all give a similar impression in appearance so that their own visual identifiability is extremely low. Further, syringes are fundamentally used with different kinds of drug solutions filled therein, respectively, as needed depending on the symptoms of patients. Before use, syringes of the same kind cannot hence be identified from each other at all from their appearances. In general, a syringe barrel is transparent, and a drug solution filled therein is visible from the outside. The drug solution is not characterized by color either so that, even when the drug solution has been filled in the syringe barrel, the thus-filled syringe is not provided with any substantially-improved visual identifiability. In a medical procedure, on the other hand, it is essential to absolutely avoid any misidentification or confusion with respect to each drug solution to be administered to a patient. For this purpose, it is necessary to permit clearly distinguishing a drug solution filled in a syringe barrel and its intended purpose when seen from the outside.
For permitting clearly distinguishing a drug solution filled in a syringe barrel, various measures have heretofore been taken to provide the thus-filled syringe with improved visual identifiability. Examples of such measures include to directly write necessary information, such as the name of a drug solution, the name of a patient and an intended purpose, on an outer wall of a syringe or to adhere a label bearing such information written thereon. It has also been proposed to prepare beforehand an indication member, for example, a slip of paper with necessary information such as the name of a drug solution and the name of a patient written thereon and to attach it to a syringe by a rubber band or the like. In order to resolve the difficulty in reading scale markings or the like that would arise when a label or indication member is adhered or otherwise attached to a syringe barrel, it has also been proposed to show information by inserting such an indication member in place within a bore formed in a thumb rest of the syringe (see Patent Document 1).
Patent Document 1: JP-A-2003-260136
However, none of the conventional measures are such that would enhance the visual identifiability of a syringe itself, and permit identifying a drug solution filled in a syringe barrel and obtaining information or the like on a patient, to which the filled drug solution is to be administered, by simply taking a glance. Moreover, the size of an area in an indication member such as a label, where information can be written, is limited, and even with such an indication member being arranged, the visual identifiability of a syringe can by no means be considered to be high. On the other hand, there are very numerous kinds of drug solutions. It is, therefore, not easy to fill a desired drug solution in a syringe while completely avoiding misidentification or confusion. To avoid the occurrence of misidentification or confusion with respect to a drug solution to be filled in a syringe, close attention is paid to the filling work of the drug solution in the syringe such as attaching beforehand an indication member, on which the drug solution to be filled and other information are described, to the syringe and filling the drug solution while confirming the details of the description of the indication member. Further, the filling work of syringes is often performed at once. In such filling work, a single kind of drug solution is filled in the plural syringes, or plural kinds of drug solutions are separately filled in the plural syringes. Even when each syringe is provided with an indication member, extremely careful and safe handling is required for filling a variety of drug solutions in the respective syringes, which are extremely low in visual identifiability, without completely avoiding misidentification or confusion and for administering the filled drug solutions to patients without any mistake.
With such current circumstances in view, the present inventors have arrived at contemplating that it would be very useful even for syringes of exactly the same configuration if the individual syringes themselves would be provided with enhanced visual identifiability. Described specifically, if plural syringes can be visually and individually identified although they are of the same kind and if their visual identities can be instantly recognized, the plural syringes of the same kind can be grouped depending on their characteristic features, and these characteristic features can be made corresponding to variables such as, for example, the kinds of drug solutions to be filled and the concentrations of the drug solutions. If handling is carried out relying upon this grouping, the worker is allowed to perform the handling while confirming the characteristic feature of each syringe, said characteristic feature being recognizable by simply taking a glance at the external appearance of the syringe, upon filling the syringe or upon administering its drug solution. The construction of each syringe in the above-described manner also makes it possible to more effectively avoid potential misidentification or confusion of a drug solution that would otherwise take place upon filling a syringe barrel with the drug solution or upon administering the filled drug solution.
It is to be noted that upon making improvements in a syringe, the following matter needs to be fully kept in mind from the special features of its application. Described specifically, a syringe is used in a medical procedure, and a drug solution filled in its syringe barrel is administered into the body of a patient. The safety of the syringe must, therefore, be secured absolutely. Accordingly, it is essential to absolutely avoid such a situation that the high-level quality, function, sanitariness and safety required for the syringe would be impaired even if an improvement can be made in the visual identifiability of the syringe itself.
An aspect of the present invention is, therefore, to provide a plunger rod capable of applying to a syringe a characteristic feature that makes it possible to readily and visually identify the syringe by simply taking a glance at its external appearance without using such a measure as attaching an indication member such as a label even if the syringe has exactly the same external appearance and configuration as plural other syringes. Another aspect of the present invention is to provide a syringe of significantly improved visual identifiability by using such a plunger rod without impairing the high-level quality, function, sanitariness and safety required for the syringe.
The above-described aspects can be achieved by the present invention to be described hereinafter. Described specifically, the present invention provides a plunger rod for a syringe, said plunger rod being useful for sliding a piston within a syringe barrel, wherein the plunger rod is colored in part or in whole.
Preferred embodiments of the above-described plunger rod can include the followings: (1) the plunger rod comprises a cylindrical barrel body provided at a leading end thereof with a piston-supporting portion formed integrally with the barrel body and a cap fitted in a hollow opening located in the barrel body at an opposite end where the piston-supporting portion is not arranged, and at least the cap is colored; (2) the plunger rod as described above in (1), in which the cap and a portion other than the cap are colored in different colors, respectively; and (3) any one of the plunger rods described above, in which a texture pattern or drawing pattern is formed by the coloring.
In another aspect of the present invention, there is also provided a syringe composed of a syringe barrel, a piston inserted within the syringe barrel, and a plunger rod with the piston supported thereon for sliding the piston, wherein the plunger rod is one of the plunger rods described above.
According to the present invention, it is possible to provide a plunger rod capable of applying to a syringe a characteristic feature that makes it possible to readily and visually identify the syringe by simply taking a glance at its external appearance without taking such a measure as attaching an indication member such as a label even if the syringe has exactly the same external appearance and configuration as plural other syringes. According to the present invention, it is also possible to provide a useful syringe of significantly improved visual identifiability by using the above-described plunger rod without impairing the high-level quality, function, sanitariness and safety required for the syringe. According to the preferred embodiments of the present invention, it is also possible, in addition to the above-described plunger rod and syringe, syringes capable of applying visual identifiability pursuant to desires from users.
The present invention will hereinafter be described in detail based on preferred embodiments. Descriptions will be made with reference to drawings that illustrate examples of certain preferred embodiments of the plunger rod according to the present invention. The plunger rod according to the present invention is characterized in that it is colored in part or in whole.
Considering that, if a syringe can be provided with enhanced visible identifiability by a simple measure without impairment to the function and safety required for the syringe, the above-described problems of the conventional syringes would be solved to provide a useful syringe which has high practical utility and enhanced convenience and which at the same time, can more effectively avoid an accident that a wrong drug solution would be administered to a patient, the present inventors have enthusiastically conducted investigations, and as a result, have led to the present invention. The present inventors first conducted an investigation on components of a syringe, that is, a syringe barrel, a piston which slides within the syringe barrel, and a plunger rod. As a result, with attention focused on the fact that among these components, the plunger rod has broader options with respect to its material compared with the other components because the plunger rod is not brought to direct contact with a drug solution, the present inventors came to a conclusion that it would be effective to make improvements in the plunger rod among the components of the syringe. As a result of a further investigation, it was found that, when plunger rods as components of plural syringes having the same configuration in external appearance are colored in part or in whole, their use would provide even the plural syringes themselves with enhanced individual visible identifiability, and moreover, their differences are extremely pronounced so that the individual syringes can be readily identified by simply taking a glance at them. A plunger rod can be formed from a synthetic resin, and therefore, it is extremely easy to color it in part or in whole. In addition, its color can be considered to be infinite. The coloring of the plunger rod can, therefore, meet any desire. Moreover, the coloring of the plunger rod in part or in whole is extremely easier as a processing step compared with modifications of its configuration, and does not significantly affect its manufacturing cost.
A syringe itself can be provided with enhanced visual identifiability when its plunger rod as a component of the syringe is colored in part or in whole and the resulting colored plunger rod is used. As a consequence, the syringe can be used as will be described hereinafter. If syringes colored in different colors at colored parts of their plunger rods, for example, for respective kinds of drug solutions to be filled in their syringe barrels, respective concentrations of a drug solution, or respective administration routes such as oral and enteral administrations are provided and the syringe-color correlations are set to always remain constant, the details of the drug solution filled in each of the syringes can be instantly ascertained by simply taking a glance on it. A medical practitioner who is about to administer the drug solution by one of the syringes can, therefore, confirm the kind or the like of the drug solution filled in its syringe barrel by simply taking a glance at the colored part of its plunger rod, said colored part characterizing the syringe, in addition to ascertaining the drug solution based on an indication member such as a label. Further, the differences in color at the colored parts of the plunger rods, said colored parts characterizing the individual syringes, can be instantly recognized even by patients themselves or by other people around the patients and medical practitioners. Therefore, a patient or any other person around the patient and medical practitioner can also become readily aware of any mistake in syringe selection in a situation such that syringes of the same color are used routinely for the patient. It, therefore, becomes possible to avoid the accident that a wrong drug solution would be administered to a patient.
In recent years, pre-filled syringes with drug solutions filled in syringe barrels thereof have also been finding wide-spread utility for the purpose of reducing the work load in medical care practice or for a like purpose. Adhered on an outer wall of each syringe barrel is a label, which shows information on the filled drug solution such as its name, concentration and fill volume. To enhance the mutual identifiability of syringes filled with different drug solutions, various contrivances have been made to labels to be adhered on the syringes. There is, however, a limitation on the contrivances to such label indications. Even with such a pre-filled syringe, it is, therefore, possible to avoid the accident that a wrong drug solution would be administered to a patient as in the case of the above-described syringe that is used by filling a drug solution in it, if the pre-filled syringe can be enhanced in visual identifiability by a characteristic feature applied to its syringe itself.
In addition, the provision of syringes themselves with enhanced own identifiability is also very useful, as will be mentioned below, upon filling work of a drug solution into the syringe barrel of each of the syringes. If a syringe which is different in color at a colored part of its plunger rod is provided for every kind or concentration of drug solution to be filled and further for every patient to whom the drug solution is to be administered, a person who conducts the filling work can conduct the filling work of the drug solution while confirming the correlation between the difference of the color and the difference of the kind or the like of drug solution. In the filling work into the syringe barrel, the worker can more surely conduct the filling work of the drug solution. As a consequence, it is possible to more effectively avoid the potential occurrence of misidentification or confusion that may arise at the stage of the filling work of the drug solution into the syringe barrel. Further, with a syringe that makes use of the plunger rod according to the present invention, information on the filled drug solution and the like can be obtained based on the difference of the applied color. It is, therefore, possible to attach an indication member such as a label to the syringe with the drug solution filled therein after completion of the filling work. As the drug solution filled in the syringe barrel can be identified by solely relying upon the difference of the color of the colored part of the plunger rod according to the present invention, it may be possible to omit the work itself that attaches the indication member such as the label to the syringe.
With reference to the drawings, a description will next be made about certain embodiments of the plunger rod according to the present invention.
Plunger rods 1,1 shown in
As a material for forming the plunger rod according to the present invention, it is necessary to use a material which is equipped with fundamental properties required for medical instruments such as antifouling property and chemical resistance and which permits sterilization and disinfection treatment or the like. In addition, the material to be used is also required to be readily colorable. Usable examples include glass, general-purpose resins such as polyethylene and polypropylene, and hard resins such as cyclic polyolefin resins, polycarbonate resins and polystyrene resin. Among these, it is preferred to use a hard resin which enables mass production at low cost. It is also preferred to use a hard resin having heat resistance and radiation resistance, because plunger rods are subjected to sterilization treatment whenever necessary. As such a resin, radiation-resistant polypropylene, cyclic olefin resin or the like can be mentioned. The plunger rod according to the present invention can be obtained by a known processing procedure such as injection molding as has conventionally been done. No particular limitation is imposed on a method for coloring the plunger rod in part or in whole. For example, a colorant such as a pigment may be added to the above-mentioned material, and processing may then be performed using the thus-colored material. As an alternative, after the plunger rod is formed from an uncolored material, the plunger rod may be directly printed at a surface thereof by a printing machine or the like to color it. When it is desired to color the plunger rod in whole, the use of a process that mixes a colorant in a forming material is preferred. When it is desired to color the plunger rod in part, on the other hand, it is preferred to use a method that prints the plunger rod at a surface thereof, or multicolor molding. In addition, the plunger rod 1 according to the present invention is not particularly limited in size, to say nothing of configuration, and its size and configuration may be determined as needed depending on the application and intended purpose of the syringe 21 in which it is used.
The plunger rods of such a conventional configuration as shown in
The members which make up the plunger rod 1 of the above-described embodiment, that is, the barrel body 5 and cap 7 will each be described in detail.
The barrel body 5, which forms the plunger rod 1 of the above-described embodiment, has a cylindrical configuration, and its hollow section extends to the end portion opposite to the leading end where the above-described piston-supporting portion 2 is formed. The hollow opening 6 is, therefore, formed in the opposite end portion (see
The cap 7, which forms the depicted plunger rod 1, has the structure that it is fitted and fixed while being maintained in close contact with a wall surface of the hollow opening 6 formed in the opposite end portion of the barrel body 5, and in combination with the flange 4 of the plunger rod 1, can form the thumb rest 3 having the planar surface against which the thumb can be firmly pressed. A description will hereinafter be made about these features.
As indicated in
As depicted in
As depicted in
The size of the plunger rod according to the above-described embodiment can be determined as desired in accordance with the configuration of the syringe barrel. If the plunger rod is designed, for example, such that the dimension of the outer diameter of the cylindrical barrel body 5, which forms the plunger rod, becomes substantially equal to the inner diameter of the syringe barrel as shown in
The above-described plunger rod exemplified in the drawings is a particularly preferred embodiment of the plunger rod according to the present invention, and needless to say, the present invention shall not be limited to it. For example, in the plunger rod 1 of the embodiment depicted in
The invention plunger rod according to the above-described embodiment formed of the two members can also be used as will be described hereinafter. In the case of the plunger rod of this embodiment, the barrel body 5 and the cap 7 are separately prepared, and the plunger rod is used with the cap 7 fitted in the hollow opening 6 formed in the barrel body 5. Because the fitting of the cap 7 is very simple as described above, its fitting work can also be conducted at the stage of use. For example, a plurality of uncolored barrel bodies 5 and a like plural number of caps 7 colored in various colors are provided. Upon use, the cap 7 of a color corresponding to the kind of a predetermined drug solution is chosen, and is then fitted in the hollow opening 6 formed in one of the barrel bodies 5 to provide the resulting plunger rod as a component for a syringe. In this manner, syringes having enhanced own visual identifiability can be obtained pursuant to the user's desire, so that a wide variety of manners can be contemplated with respect to their use. Therefore, the plunger rods provided as described above are very useful.
The syringe 21 according to the present invention is characterized in that it is formed of at least the syringe barrel 12, the piston 11 inserted within the syringe barrel 12, and the plunger 1 with the piston 11 supported thereon for sliding the piston 11, and the plunger rod 1 is the above-described plunger rod 1 according to the present invention (see
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|1||International Search Report for PCT/JP2008/053603 dated Mar. 25, 2008.|
|2||Japanese Office Action for Japanese Patent Application No. 2010-500499 dated Jan. 24, 2012.|
|Clasificación internacional||A61M5/31, A61M5/315|
|Clasificación cooperativa||A61M2205/6081, A61M2205/583, A61M2005/3121, A61M5/31511|
|6 Ago 2010||AS||Assignment|
Owner name: DAIKYO SEIKO, LTD., JAPAN
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:KAWAMURA, HIDEAKI;TOGASHI, HIROSHI;REEL/FRAME:024803/0813
Effective date: 20100712