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Número de publicaciónUSRE30199 E
Tipo de publicaciónConcesión
Número de solicitudUS 05/953,688
Fecha de publicación29 Ene 1980
Fecha de presentación23 Oct 1978
Fecha de prioridad29 Nov 1973
Número de publicación05953688, 953688, US RE30199 E, US RE30199E, US-E-RE30199, USRE30199 E, USRE30199E
InventoresDavid Rose, Ferdi Saygin, Erwin Weinrich
Cesionario originalHenkel Kommanditgesellschaft Auf Aktien (Henkel Kgaa)
Exportar citaBiBTeX, EndNote, RefMan
Enlaces externos: USPTO, Cesión de USPTO, Espacenet
Oxidation hair dyes based upon tetraaminopyrimidine developers
US RE30199 E
Resumen
An aqueous hair dye preparation comprising an oxidation dyestuff combination of a coupling component and a developer component consisting of a tetraaminopyrimidine derivative or a water-soluble acid addition salt thereof, as well as a process for dyeing hair by utilizing this oxidation dyestuff combination.
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Reclamaciones(9)
We claim:
1. An aqueous preparation for the dyeing of hair consisting essentially of (1) from 0.2% to 5% by weight of an oxidation dyestuff combination of a developer component, and a coupling component in substantially equimolar amounts, said developer component consisting essentially of (A) a tetraaminopyrimidine of the formula ##STR9## wherein R1, R2, R3, R4, R5 and R6 are each selected from the group consisting of hydrogen, phenyl, 6-alkyl having 1 to 4 carbon atoms, phenylalkyl having 7 to 10 carbon atoms, phenylalkenyl having 7 to 10 carbon atoms,
X--(CH2)n --
wherein n is an integer from 1 to 4, and X is selected from the group consisting of hydroxyl, halogen and NR7 R8 -- in which R7 and R8 are selected from the group consisting of hydrogen and alkyl having 1 to 4 carbon atoms, and together with the nitrogen atom R7 to R8 form a 5 to 6 membered heterocyclic ring optionally containing an additional nitrogen atom or an oxygen atom,
and wherein R1 and R2 or R3 and R4 or R5 and R6, together with the nitrogen atom form a 5 to 6 membered heterocyclic ring, optionally containing another nitrogen or oxygen atom in the ring or (B) a water-soluble acid addition salt of (A); (2) from 0% to 5% by weight of a direct dyestuff; (3) from 0% to 30% by weight of a surfactant; (4) from 0% to 25% by weight of a thickener; and (5) the balance up to 100% by weight of water.
2. The aqueous preparation of claim 1, wherein R1, R2, R3, R4, R5 and R6 are each selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, n-propyl, butyl, phenyl, benzyl, benzylidene; and --(CH2)n --X
wherein R1 and R2 or R3 and R4, or R5 and R6, together with the nitrogen atom form a substituent selected from the group consisting of piperidino and morpholino; and
wherein n is 1,2 or 3 and X is selected from the group consisting of hydroxyl, halogen and --NR7 R8 in which R7 and R8 are selected from the group consisting of hydrogen and alkyl having 1 to 4 carbon atoms.
3. The aqueous preparation of claim 1, wherein said coupling component is selected from the group consisting of (a) a 1-phenyl-pyrazol-5-one, (b) an aromatic amine (c) an aromatic alcohol, and (d) a pyrazolidinedione.
4. The aqueous preparation of claim 1, wherein there is from 1% to 3% by weight of said oxidation dyestuff combination.
5. The aqueous preparation of claim 1, wherein the developer component is selected from the group consisting of (A) 2,4,5,6-tetraamino-pyrimidine, 4-dimethylamino-2,5,6-triaminopyrimidine, 2-dimethylamino-4,5,6-triamino-pyrimidine, 2-piperidino-4,5,6-triamino-pyrimidine, 2-morpholino-4,5,6-triamino-pyrimidine, 6-morpholino-2,4,5-triamino-pyrimidine, 6-piperidino-2,4,5-triamino-pyrimidine, 6-(di-n-propylamino)-2,4,5-triamino-pyrimidine, 5-amino-2,4,6-tris-(methylamino)-pyrimidine and 2-methylamino-4,5,6-triamino-pyrimidine and (B) a water soluble acid addition salt of (A).
6. The aqueous preparation of claim 1, wherein said coupling component is selected from the group consisting of (a) a m-aminophenol of the formula ##STR10## wherein Z and Y are each selected from the group consisting of hydrogen, halogen, hydroxyl, amino, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, alkylamino having 1 to 4 carbon atoms, dialkylamino having 1 to 4 carbon atoms in each of the alkyls;
wherein R9 is selected from the group consisting of alkyl having 1 to 10 carbon atoms, hydroxyalkyl having 1 to 10 carbon atoms, phenyl, anilino, hydroxyphenyl, benzyl, methylenecyanamido, propionamido, ureido, thioureido, oxalyl ester of an alcohol having 1 to 4 carbon atoms,
M--(CH2)m --
wherein m is an integer from 1 to 4 and M is selected from the group consisting of hydroxyl, halogen, and --NR11 R12, in which R11 and R12 are selected from the group consisting of hydrogen and alkyl having 1 to 4 carbon atoms and wherein R10 is selected from the group consisting of hydrogen and R9,
wherein R9 and R10 can together with the nitrogen atom form a five to six membered heterocyclic ring optionally containing an additional nitrogen atom or an oxygen atom and
b. a water-soluble acid addition salt of (a).
7. The aqueous preparation of claim 6,
wherein Z and Y are each selected from the group consisting of hydrogen, methyl, methoxy, amino, chloro and hydroxyl;
wherein R9 is selected from the group consisting of methyl, ethyl, octyl, propyl, hydroxyethyl, phenyl, benzyl, anilino, hydroxyphenol, ureido, thioureido, methylenecyanamido and diethylaminoethyl,
wherein R10 is selected from the group consisting of hydrogen and R9,
and wherein R9 and R10 together with the nitrogen atom form a member selected from the group consisting of pyrrolidino, morpholino, and piperidino.
8. A process for the dyeing of human hair comprising applying to said hair at temperatures ranging substantially from 15° C. to 40° C. for a time sufficient to effect dyeing, an effective amount of the aqueous preparation of claim 1.
9. The process for the dyeing of human hair of claim 8, wherein said preparation also contains a chemical oxidizing agent.
Descripción
THE PRIOR ART

Of great importance for the dyeing of hair are the so-called oxidation dyestuffs because of their intensive colors and very good fastness. These dyestuffs are formed by the oxidative coupling of a developer component with a coupling component. The developers customarily used are nitrogenous bases, such as p-phenylenediamine derivatives, diaminopyridines, 4-aminopyrazolone derivatives or heterocyclic hydrazones. Useful as so-called coupling components are m-phenylenediamine derivatives, phenols, naphthols, resorcinol derivatives and pyrazolones.

Good oxidation dyestuff components for hair dyeing must fulfill all of the following requirements.

They have to be able to develop a sufficient intensity of the desired color shades when oxidatively coupled with the respective developer component or coupling component. Furthermore, they have to possess a capacity for being absorbed by human hair, which capacity ranges from sufficient to very good; and in addition, they should be unobjectionable from toxicological and dermatological viewpoints.

As developers, it is customary to use the class of compounds consisting of substituted or unsubstituted p-phenylenediamines. However, this class of compounds has the disadvantage that sensitivity reactions and subsequently severe allergies are caused in numerous persons. The developers which have been recently proposed for avoiding these dermatological disadvantages are not always fully satisfactory with respect to their technical application.

OBJECTS OF THE INVENTION

An object of the invention is to provide usable oxidation hair dyes containing suitable components which optimally satisfy the above requirements.

Another object of the present invention is to provide an oxidation dyestuff combination of a coupling component and a developer component, which is based on tetraaminopyrimidines as the developer component.

These and further objects of the present invention will become apparent as the description thereof proceeds.

DESCRIPTION OF THE INVENTION

The present invention provides a composition and process for dyeing hair based upon an oxidation dyestuff combination of a coupling component and a developer component with tetraaminopyrimidines being the developer component, as well as novel tetraaminopyrimidines. It has now been found that the abovespecified requirements can be fulfilled to an especially significant extent by the use of hair coloring preparations that are based on oxidation dyestuff combinations containing tetraaminopyrimidines of the formula ##STR1## and their inorganic or organic water-soluble acid addition salts as developers, and containing the couplers customarily used in oxidation hair dyes, in which R1 to R6 are each selected from the group consisting of hydrogen, alkyl having 1 to 4 carbon atoms, aryl, substituted aryl and --(CH2)n --X, in which n is an integer from 1 to 4, and X is selected from the group consisting of hydroxy, halogen and --NR7 R8 wherein R7 and R8 are selected from the group consisting of hydrogen and alkyl having 1 to 4 carbon atoms and can form with the nitrogen atom a heterocyclic ring which may contain one additional nitrogen atom or an oxygen atom. In the above formula, R1 to R6 likewise can designate an optionally substituted five-membered or six-membered heterocyclic ring containing one or two nitrogen atoms, or one nitrogen atom and one oxygen atom.

More particularly, the present invention is directed to an aqueous preparation for the dyeing of hair consisting essentially of (1) from 0.2% to 5% by weight of an oxidation dyestuff combination of a developer component, and a coupling component in substantially equimolar amounts, said developer component consisting essentially of (A) a tetraaminopyrimidine of the formula ##STR2## wherein R1, R2, R3, R4, R5 and R6 are each selected from the group consisting of hydrogen, phenyl, alkyl having 1 to 4 carbon atoms, phenylalkyl having 7 to 10 atoms, phenylalkenyl having 7 to 10 carbon atoms,

X--(CH2)n --

wherein n is an integer from 1 to 4, and X is selected from the group consisting of hydroxyl, halogen and NR7 R8 -- in which R7 and R8 are each hydrogen or alkyl having 1 to 4 carbon atoms, and together with the nitrogen atom R7 and R8 from a member selected from the group consisting of a 5 to 6 membered heterocyclic ring optionally containing an additional nitrogen atom or oxygen atom,

and wherein R1 and R2, or R3 and R4, or R5 and R6, together with the nitrogen atom form a five to six membered heterocyclic ring optionally containing another nitrogen or oxygen atom in the ring and (B) a water-soluble acid addition salt of (A); (2) from 0% to 5% by weight of a direct dyestuff; (3) from 0% to 30% by weight of a surfactant; (4) from 0% to 25% by weight of thickeners; and (5) the balance up to 100% by weight of water.

A particularly preferred subgenus of the above-mentioned developer component is wherein R1, R2, R3, R4, R5 and R6 are each selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, n-propyl, butyl, phenyl, benzyl and benzylidene, or --(CH2)n --X

wherein R1 and R2, or R3 and R4, or R5 and R6, together with the nitrogen atom form a substituent selected from the group consisting of hydroxyl, halogen and --NR7 R8 in which R7 and R8 are each hydrogen or alkyl having 1 to 4 carbon atoms.

When the compounds according to the invention are used as developer components, they react with the known couplers generally used in oxidation hair dyestuffs to give very intensive, varying shades which previously heretofore could not be effected with these known couplers and these developers known so far. Thus, the compounds of the invention considerably increase the possibilities for utilizing oxidation hair dyes. Furthermore, the tetraaminopyrimidines according to the invention are distinguished by very good fastness of the dyeings effects with them, by good water-solubility, by good storage stability, and by excellent toxicological as well as dermatological unobjectionableness.

The tetraaminopyrimidines which are to be used as developer components according to the invention can be used either as such or in form of their water-soluble acid addition salts with non-toxic inorganic acids or organic acids, such as for example, hydrochloric acid, sulfuric acid, phosphoric acid, acetic acid, propionic acid, lactic acid or citric acid.

The preparation of most tetraaminopyrimidines to be used as developer components according to the invention is already known in the literature and can be taken from the monograph by D. J. Brown, in the series "Heterocyclic Compounds", Interscience Publishers, 1962, Vols. I and II, "The Pyrimidines". Only a few of the compounds used are novel substances, the preparation of which is separately described below.

Specific examples of the novel tetraaminopyrimidines according to the invention are 5-amino-2,4,6-tris(methylamino)-pyrimidine, 2,4,5-triamino-6-(di-n-propylamino)-pyrimidine and 2,4,5-triamino-6-morpholino-pyrimidine, or a water-solution acid addition salt thereof.

To synthesize the compounds to be used according to the invention, the starting material generally is a 2,4,6-aminopyrimidine, into which the 5-amino group is introduced by nitrosation and subsequent reduction. It is also possible to start from the correspondingly substituted triaminoalkylmercaptopyrimides and to replace the alkylmercapto group with an amino group. The latter method is especially suitable for the introduction of substituted amino groups into the 2-, 4-, or 6-positions of the pyrimidine ring. Suitable examples of developer components to be used according to the invention are, for example: 2,4,5,6-tetraamino-pyrimidine, 4,5-diamino-2,6-bis-(methylamino)-pyrimidine,

2,5-diamino-4,6-bis-(methylamino)-pyrimidine,

4,5-diamino-6-(butylamino)-2-(dimethylamino)-6-pyrimidine,

2,5-diamino-4-(diethylamino)-6-(methylamino)-pyrimidine,

4,5-diamino-6-(diethylamino)-(2-dimethylamino)-pyrimidine,

4,5-diamino-2-(diethylamino)-6-(methylamino)-pyrimidine,

4,5-diamino-2-(dimethylamino)-6-(ethylamino)-pyrimidine,

4,5-diamino-2-(dimethylamino)-6-(isopropylamino)-pyrimidine,

4,5-diamino-2-(dimethylamino)-6-(methylamino)-pyrimidine,

4,5-diamino-6-(dimethylamino)-2-(methylamino)-pyrimidine,

4,5-diamino-2-(dimethylamino)-6-(propylamino)-pyrimidine,

2,4,5-triamino-6-(dimethylamino)-pyrimidine,

4,5,6-triamino-2-(dimethylamino)-pyrimidine,

2,4,5-triamino-6-(methylamino)-pyrimidine,

4,5,6-triamino-2-(methylamino)-pyrimidine,

4,5-diamino-2-(dimethylamino)-6-piperidino-pyrimidine,

4,5-diamino-6-(methylamino)-2-piperidino-pyrimidine,

2,4,5-triamino-6-piperidino-pyrimidine,

2,4,5-triamino-6-anilino-pyrimidine,

2,4,5-triamino-6-(benzylamino)-pyrimidine,

2,4,5-triamino-6-(benzylideneamino)-pyrimidine,

4,5,6-triamino-2-piperidino-pyrimidine,

5-amino-2,4,6-tris-(methylamino)-pyrimidine,

2,4,5-triamino-6-(di-n-propylamino)-pyridine,

2,4,5-triamino-6-morpholino-pyrimidine,

2,.Badd..[.4.]..Baddend..Iadd.5.Iaddend.,6-triamino-4-(dimethylamino)-pyrimidine

4,5,6-triamino-2-morpholino-pyrimidine,

2,4,5-triamino-6-(β-hydroxyethyl-amino)-pyrimidine,

4,5,6-triamino-2-[(β-aminoethyl)amino]-pyrimidine,

2,5,6-triamino-4-[(β-methylamino)-ethylamino]pyrimidine,

2,5-diamino-4,6[bis-(γ-diethylamino)-propylamino]-pyrimidine,

4,5-diamino-6-[(.[.B.]..Iadd.β.Iaddend.-hydroxyethyl)-amino]-2-(methylamino)-pyrimidine,

5-amino-2,4,6-(triethylamino)-pyrimidine, and

5-amino-6-anilino-2,4-[bis-(β-hydroxyethyl)-amino]-pyrimidine.

Generally speaking, the coupling components include 1-phenyl-pyrazol-5-ones, aromatic amines, aromatic alcohols, preferably m-aminophenols, 1,3-diamino-4-nitrobenzenes, 1,4-diamino-2-nitrobenzenes and pyrazolidine-diones.

Examples of coupling components include 1-phenylpyrazol-5-one derivatives of the formula ##STR3## wherein D represents lower alkyl such as methyl, NH2 --,--NH--CO--D1 or --NH--CO--NH--D1 or NH--CS--NH--D1 and D1 denotes a hydrocarbon radical with 1 to 12 carbon atoms or a heterocylic radical, and preferably D1 is alkyl having 1 to 6 carbon atoms such as methyl, ethyl, isopropyl, n-propyl, n-butyl; phenyl; halopenyl such as p-chlorophenyl; alkylphenyl having from 7 to 12 carbon atoms such as p-methylphenyl, p-ethylphenyl, o-propylphenyl; alkoxyphenyl, having from 7 to 12 carbon atoms such as o-methoxyphenyl p-isopropoxyphenyl; dialkylaminophenyl having 1 to 4 carbon atoms in the alkyl such as p-dimethylaminophenyl; cyclohexyl; alkylcyclohexyl having from 7 to 12 carbon atoms such as methylcyclohexyl; pyridyl; and piperidyl.

Examples of readily available substituted 1-phenyl-3-aminopyrazol-5-ones are the following:

1-phenyl-3-amino-pyrazol-5-one,

1-phenyl-3-methyl-pyrazol-5-one,

1-phenyl-3-acetamido-pyrazol-5-one,

1-phenyl-3-benzamido-pyrazol-5-one,

1-phenyl-3-(3'-cyclohexylureido)-pyrazol-5-one,

1-phenyl-3-(3'-phenylureido)-pyrazol-5-one,

1-phenyl-3-(3'-p-chlorophenylureido)-pyrazol-5-one,

1-phenyl-3-(3'-ethyl-2'-thioureido)-pyrazol-5-one,

1-phenyl-3-(3'-n-butyl-2'-thioureido)-pyrazol-5-one,

1-phenyl-3-(3'-phenyl-2'-thioureido)-pyrazol-5-one,

1-phenyl-3-(3'methylureido)-pyrazol-5-one,

1-phenyl-3-(3'-ethylureido)-pyrazol-5-one,

1-phenyl-3-(3'-n-propylureido-pyrazole-5-one,

1-phenyl-3-(3'-isopropylureido)-pyrazol-5-one, and

1-phenyl-3-(3'-n-butylureido)-pyrazol-5-one.

Another coupling component for the hair dyes is based on aromatic amines and/or aromatic alcohols, preferably a compound having the formula

E--Ar--F

in which Ar represents an aromatic nucleus, preferably consisting of naphthylene, hydroxynaphthylene, aminonaphthylene, phenylene, aminophenylene, hydroxyphenylene, toluylene, alkoxyphenylene having from 7 to 10 carbon atoms and quinolylene; E represents hydrogen, hydroxyl, or amino, dialkylamino having from 1 to 4 carbon atoms in the alkyls; and F represents hydroxyl, amino or dialkylamino having from 1 to 4 carbon atoms in the alkyls.

Suitable coupling components include aromatic amines and diamines, phenols, naphthols and aminophenols. The metacompounds are preferably used in the case of the diamines, aminophenols and phenols. When diamines are used, those in which the hydrogen atoms of the amino groups are substituted by lower alkyl residues (C1 -C4) may also be used.

The following compounds are examples of the said coupling components:

m-cresol,

m-phenylenediamine,

o-cresol,

m-aminophenol,

anisidine,

2,4-diaminoanisole,

m-toluylenediamine,

resorcinol,

pyrogallol,

pyrocathechol,

resorcinol-monoethyl ether

resorcinol-monomethyl ether,

m-aminoresorcinol,

1,5-dihydroxynaphthalene,

1,6-dihydroxynaphthalene,

1,7-dihydroxynaphthalene,

2,7-dihydroxynaphthalene,

1,5-amino- or 1,8-amino-hydroxynaphthalene,

α-naphthol,

7-(dimethylamino)-4-hydroxy-1-methyl-2-quinoline,

8-hydroxyquinoline,

1,8-diaminonaphthalene,

2,6-dimethyl-phenol,

2,5-dimethyl-phenol,

3,4-dimethyl-phenol,

3,5-dimethyl-phenol,

5-amino-2-methyl-phenol,

hydroquinone,

4-aminophenol,

Other coupling compounds include

1,3-diamino-4-nitrobenzene derivatives of the formula ##STR4## and 1,4-diamino-2-nitrobenzene derivatives of the formula ##STR5## in which X is an electrophilic substituent and A2 is a member selected from the group consisting of hydrogen, alkyl of 1 to 10 carbon atoms, hydroxyalkyl of 1 to 10 carbon atoms; N,N-dialkyl-aminoalkyl of 3 to 18 carbon atoms, alkanoyl of 2 to 10 carbon atoms, substituted alkanoyl of 2 to 10 carbon atoms with a substituent selected from the group consisting of nitro, phenyl, halo, cyano, carboxy and sulfo, acyl of aromatic hydrocarbon carboxylic acids having 7 to 15 carbon atoms, substituted acyl of aromatic hydrocarbon carboxylic acids having from 7 to 15 carbon atoms with a substituent selected from the group consisting of lower alkyl, nitro, halo, cyano, carboxyl and sulfo, and the activated methylene group --CO--CH2 --X, in which X is an electrophilic substituent.

An electrophilic substituents X, the radicals containing a carbonyl, such as carboxyl, alkoxycarbonyl, and acyl, or a nitrile, or carbonyl containing radicals further substituted with halogen, the sulfo group and the nitro group, are considered. X is preferably a nitrile, acyl, or alkoxycarbonyl group.

Examples of X include carboxyl, cyano, alkanoyl of 2 to 10 carbon atoms, substituted alkanoyl of 2 to 10 carbon atoms with a substituent selected from the group consisting of nitro, phenyl, halo, cyano, carboxyl and sulfo, acyl of aromatic hydrocarbon carboxylic acids having 7 to 15 carbon atoms, substituted acyl of aromatic hydrocarbon carboxylic acids having from 7 to 15 carbon atoms with a substituent selected from the group consisting of lower alkyl, nitro, halo, cyano, carboxyl and sulfo, cycloalkylcarbonyl of 6 to 10 carbon atoms, alkoxylcarbonyl of 2 to 10 carbon atoms, cycloalkoxycarbonyl of 6 to 10 carbon atoms, phenylalkoxycarbonyl of 8 to 16 carbon atoms, furoyl, and thenoyl.

Suitable examples for compounds of the above described diamino-nitrobenzenes are as follows:

1-amino-3-cyanoacetylamino-4-nitrobenzene,

1-benzoylacetylamino-3-amino-4-nitrobenzene,

1-methylamino-3-cyanoacetylamino-4-nitrobenzene,

1,3-di(cyanoacetylamino)-4-nitrobenzene,

1,3-Di(ω-ethoxycarbonyl-acetylamino)-4-nitrobenzene,

1-Amino-3(ω-ethoxycarbonyl-acetylamino)-4-nitrobenzene,

1-Acetylamino-3-cyanoacetylamino-4-nitrobenzene,

1-Amino-3-acetoacetylamino-4-nitrobenzene,

1-(ρ-Nitro-benzylacetylamino)-3-amino-4-nitrobenzene,

1-Trifluoro-acetoacetylamino-3-amino-4-nitrobenzene,

1-(2-Hydroxy-ethylamino)-3-cyanoacetylamino-4-nitrobenzene,

1-Amino-2-nitro-4-ω-cyanoacetylamino-benzene,

1-Amino-2-nitro-4-ω-benzoyl-acetylamino-benzene,

1,4-Dicyanoacetylamino-2-nitrobenzene,

1-Amino-2-nitro-4-ω-ethoxycarbonyl-acetylamino-benzene,

1,4-Bis-(ω-ethoxycarbonyl-acetylamino)-2-nitrobenzene,

1-Amino-2-nitro-4ω-benzoxycarbonyl-acetylamino-benzene,

1-Amino-2-nitro-4-(ρ-nitrobenzoyl-acetylamino)-benzene,

1-Amino-2-nitro-4-acetoacetylamino-benzene,

1-Amino-2-nitro-4-nitroacetoacetylamino-benzene,

1-Amino-2-nitro-4-trifluoroacetoacetylamino-benzene,

1-Amino-2-nitro-4-ω-butyryl-acetylamino-benzene,

1-Amino-2-nitro-4-ω-(β-Naphthoylacetylamino)-benzene,

1-Amino-2-nitro-4-cyclohexylcarbonyl-acetylamino-benzene,

1-Amino-2-nitro-4-Furoylacetylamino-benzene,

1-Amino-2-nitro-4-Thenoylacetylamino-benzene,

1,4-Bis-(ω-butoxycarbonyl-acetylamino)-benzene,

1,4-Bis-(ω-cyclohexyloxycarbonyl-acetylamino)-benzene.

Further coupling components include pyrazolidinediones such as 1-phenyl-3,5-pyrazolidine dione.

Specific examples of preferred coupling components to be used for the hair dyes according to the invention are as follows:

α-naphthol,

o-cresol,

m-cresol,

2,6-dimethylphenol,

2,5-dimethylphenol

3,4-dimethylphenol,

3,5-dimethylphenol

pyrocatechol,

pyrogallol

1,5-dihydroxy-naphthalene,

1,7-dihydroxy-naphthalene,

5-amino-2-methylphenol,

hydroquinone,

2,4-diaminoanisole,

m-toluylenediamine

4-aminophenol,

resorcinol,

resorcinol monomethyl ether m-phenylenediamine,

3-methyl-1-phenyl-pyrazolone-5,

3-amino-1-phenyl-pyrazolone-5,

1-phenyl-3,5-dione-pyrazolidine,

7-(dimethylamino)-4-hydroxy-1-methyl-quinolone-2,

1-amino-3-(acetacetylamino)-4-nitrobenzene,

1-amino-3-(cyanoacetylamino)-4-nitrobenzene.

In order to obtain shades which are as strong as possible and which correspond to natural hair colors to a large extent, it is very important to use a superior blue dye as shade component. In the preparation of natural looking shades with the aid of coupler components for producing blue dyes, there are, however, difficulties encountered with the customary blue-couplers even when the otherwise very satisfactory tetraaminopyrimidines are used as developers.

It has now been found that this drawback can be corrected when, in combination with the tetraaminopyrimidines employed as developers, the following m-aminophenols are used as the coupling components. These m-aminophenols have the formula ##STR6## wherein Z and Y are each selected from the group consisting of hydrogen, halogen, hydroxyl, amino, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, alkylamino having 1 to 4 carbon atoms, dialkylamino having 1 to 4 carbon atoms in each of the alkyls; R9 is selected from the group consisting of alkyl having 1 to 10 carbon atoms, phenyl optionally substituted, benzyl, methylenecyanamido, propionamido, ureido, thioureido, oxalyl ester having 1 to 4 carbon atoms in the alcohol moiety, M--(CH2)m --in which m is an integer from 1 to 4 and M is selected from the group consisting of hydroxyl, halogen, and--NR11 R12 in which R11 and R12 are each hydrogen or alkyl having 1 to 4 carbon atoms, and in which R9 and R10 can together with the nitrogen atom form an optionally substituted five- or six-membered heterocyclic ring which may contain an additional nitrogen atom or an oxygen atom, and R10 is selected from the group consisting of hydrogen and R9.

More particularly the coupling component is selected from the group consisting of (a) m-aminophenol of the formula ##STR7## wherein Z and Y are each selected from the group consisting of hydrogen, halogen, hydroxyl, amino, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, alkylamino having 1 to 4 carbon atoms, dialkylamino having 1 to 4 carbon atoms in each of the alkyls;

Wherein R9 is selected from the group consisting of alkyl having 1 to 10 carbon atoms, hydroxyalkyl having 1 to 10 carbon atoms, phenyl, anilino, hydroxyphenyl, benzyl, methylenecyanamido, propionamido, ureido, thioureido, oxalyl ester of an alcohol having 1 to 4 carbon atoms,

M--(CH2)m --

wherein m is an integer from 1 to 4 and M is selected from the group consisting of hydroxyl, halogen, and --NR11 R12, in which R11 and R12 are each hydrogen or alkyl having 1 to 4 carbon atoms and wherein R10 is selected from the group consisting of hydrogen and R9,

wherein R9 and R10 can together with the nitrogen atom form a member selected from the group consisting of a five- or six-membered heterocyclic ring optionally containing in the ring oxygen or nitrogen and

b. a water-soluble acid addition salt of (a).

A particularly preferred subgenus of said coupling component is

wherein Z and Y are each selected from the group consisting of hydrogen, methyl, methoxy, amino, chloro, and hydroxyl;

wherein R9 is selected from the group consisting of methyl, ethyl, octyl, propyl, hydroxyethyl, phenyl, benzyl, anilino, hydroxyphenyl, ureido, thioureido, methylene-cyanamido, and diethylaminoethyl,

wherein R10 is selected from the group consisting of hydrogen and R9,

and wherein R9 and R10 together with the nitrogen atom form a member selected from the group consisting of pyrrolidino, morpholino, and piperidino.

The m-aminophenol derivatives to be employed as blue-coupling component can be used either as such or in form of their water-soluble acid addition salts with inorganic or organic acids, such as for example, hydrochloric acid, sulfuric acid, phosphoric acid, acetic acid, propionic acid, lactic acid and citric acid.

Suitable examples of blue-coupling components to be employed according to the invention are as follows:

3-(dimethylamino)-phenol,

3-(diethylamino)-phenol,

3-(dioctylamino)-phenol,

3-(ethylmethylamino)-phenol,

3-(ethylpropylamino)-phenol,

3-(phenylethylamino)-phenol,

3-(phenyloctylamino)-phenol,

3-(benzylamino)-phenol,

3-(ethylbenzylamino)-phenol,

3-anilinophenol,

3-(methylamino)-phenol,

3-(ethylamino)-phenol,

3-(octylamino)-phenol,

3-(ethylureidoamino)-phenol,

3-ureidophenol,

3-(phenylureidoamino)-phenol,

3-(β-hydroxyethyl amino)-phenol,

3-(N-β-hydroxyethyl-N-methyl-amino)-phenol,

3-(thioureidoamino)-phenol,

N-ethyl-N-(3-hydroxyphenyl)-urea,

3-(methylenecyanamido)-phenol,

3-((2-diethylamino)-ethyl)-amino)-phenol,

3-N-(2-diethylaminoethyl)-N-methyl-aminophenol,

3-pyrrolidinophenol,

3-morpholinophenol,

3-piperidinophenol,

5-(ethylamino)-2-methylphenol,

5-(diethylamino)-2-methylphenol

3-ethylamino)-4-methoxyphenol,

3-diethylamino)-4-methoxyphenol,

2-chloro-5-(dimethylamino)-phenol

3,5-dihydroxy-N,N-dimethylaniline,

2-amino-5-(diethylamino)-phenol,

6-chloro-3-(diethylamino)-5-hydroxy-toluene,

3-anilino-6-chloro-5-hydroxy-toluene,

5-methyl-3-piperidino-phenol, and

4-chloro-3-pyrrolidino-phenol.

The preparation of the m-aminophenol derivatives to be used as blue-coupling components is already known from the literature. See the article of F. Effenberger et al in Chem. Ber. 103, 1456-62, (1970) and British Pat. No. 974,343. The preparation of several novel derivatives which were not found in the literature is separately described below.

Specific examples of novel m-aminophenols are as follows: 3-(diethylamino)-4-methoxy-phenol, 5-(ethylamino)-2-methyl-phenol and 5-(diethylamino)-2-methyl-phenol, as well as water-soluble acid addition salts thereof.

In the hair coloring preparations according to the invention, substantially equimolar quantities of the developer components are used based on the coupling components employed. Although an equimolar amount is preferred, it is possible to use more or less than molar amounts. Furthermore, the developer component and the coupling component may be used as pure ingredients or as mixtures. Not only can the developer component consist of mixtures of the tetraaminopyrimidines to be used according to the invention, but the coupling component can also consist of mixtures of the above-named coupling components.

In addition, the hair coloring preparations according to the invention can contain admixtures of other customary developing components and, if necessary, can also contain the customary direct dyestuffs in case the latter are needed for obtaining certain shades. From 0% to 5% direct dyestuffs may be employed. As in the case of other oxidation hair dyes, the oxidative coupling, i.e., the development of the dye can in principle be effected by atmospheric oxygen. Moreover, it is preferred to use chemical oxidizing agents. Suitable examples are especially hydrogen peroxide or its products of addition to urea, melamine and sodium borate, as well as mixtures of such hydrogen peroxide addition products with potassium peroxydisulfate.

When the tetraaminopyrimidines according to the invention are used as developer components, they have the advantage that the oxidative coupling with atmospheric oxygen readily produces highly satisfactory hair dyeing results. Thus, damage to the hair by the oxidizing agents, otherwise employed for oxidative coupling, can be prevented.

In the situation that a bleaching of the hair is simultaneously desired, then the concurrent use of chemical oxidizing agents is necessary.

For application, the hair dyes according to the invention are incorporated into suitable aqueous cosmetic preparations, such as creams, emulsions, gels or simple solutions and immediately before application to the hair, one of the above-named oxidizing agents is added. These hair dyeing preparations contain coupling and developing components in amounts of from 0.2% to 5% by weight, preferably from 1% to 3% by weight.

For the preparation of creams, emulsions or gels, the dye components are mixed with the additional ingredients customarily used in such preparations. Such additional ingredients are, for example, wetting agents or emulsifiers of the anionic or nonionic type, such as alkylbenzenesulfonates, higher fatty alcohol sulfates, higher alkylsulfonates, higher fatty acid alkanolamides, ethoxylated fatty alcohols; thickeners such as methyl cellulose, starch, higher fatty alcohols, paraffin oil and higher fatty acids. Furthermore, perfumes and hair-conditioning and grooming agents, such as panthothenic acid and cholesterol may be included.

Effective amounts of the above-named additives are those customarily employed for this purpose. Effective amounts of wetting agents range from 0.5% to 30% by weight, preferably from 1% to 15% by weight; and for thickeners, an effective amount ranges from 0.1% to 25% by weight, preferably from 1% to 15% by weight, based in each case on the total weight of the preparation. As a lower limit for the above additives, a zero percent lower limit is possible, if none of the additive is utilized.

The hair coloring preparations according to the invention can be applied in a weakly acid medium, a neutral medium or especially, in an alkaline medium, preferably at a pH of 8 to 10, regardless whether a solution, an emulsion, a cream, or a gel is employed.

These preparations are applied at a temperature which usually ranges from 15° C. to 40° C. and preferably is room temperature.

After the preparation has been allowed to react for about 30 minutes, the hair coloring preparation is removed from the hair to be dyed, by rinsing. Then the hair is washed with a mild shampoo, and finally is dried.

When different developer and coupling components are used, the shades obtainable by use of the hair coloring preparations according to the invention have the advantage of providing an extraordinary variations which extend from ash blond to dark brown and green to violet. The properties of the hair colors produced are excellent as far as fastness to light and washing are concerned, as well as good resistance to abrasion is concerned; and the hair dyes once fixed can be easily removed by means of reducing agents.

The following examples are merely illustrative of the present invention without being deemed limitative in any manner thereof.

EXAMPLES

First, there are examples for the preparation of some novel tetraminopyrimidines which are utilized according to the invention, but have not been previously described in the literature.

EXAMPLE 1 Preparation of 5-Amino-2,4,6-tris-(methylamino)-pyrimidine Sulfate, C7 H14 N6 ·H2 SO4 ·2H2 O

2,4,6-tris(methylamino)-pyrimidine was prepared according to Winkelmann, J. Pract. Chem. 115, 292 (1927) and 5.5 gm of this compound were dissolved in 50 ml water. The solution was adjusted to a pH of 4 by means of sodium acetate and was then heated to 80° C.; and a solution of 1.4 gm of NaNO2 in 5 ml of H2 O was added to form a red solution. At 60° C., sodium dithionite was added until the solution became yellow. Dilute H2 SO4 was added to the yellow solution; and the precipitate was vacuum filtered. The yield was 55%; and the melting point was 215° C.

______________________________________Elemental Analysis:          % C       % H       % N______________________________________Found:         26.6      6.4       26.6Calculated:    26.6      8.3       27.7______________________________________
EXAMPLE 2 Preparation of 2,4,5-Triamino-6-(di-n-propylamino)-pyrimidine Dihydrochloride, C10 H20 H6 ·2 HCl

2,4,5-Triamino-6-(di-n-propylamino)pyrimidine dihydrochloride was prepared stepwise as follows:

1. 2,4-Diamino-6-(di-n-propylamino)-pyrimidine

2,4-Diamino-6-chloropyrimidine was prepared according to Roth et al, J. Amer. Chem. Soc. 72, 1914 (1950). To 15 gm of this compound in 130 ml of ethanol, there was added 50 gm of di-n-propylamine, and the mixture was heated in an autoclave at 200° C. for three hours (at an initial gauge pressure of 10 atm. of N2). After the autoclave had cooled and had been opened, the reaction mixture was cooled in an ice-salt bath to precipitate dipropylamine hydrochloride. After filtration, the mother liquor was considerably concentrated to give a residue of about 30 ml, whereby 18 gm or 82.9% of theory of crude raw product precipitated. This product was used as such for subsequent synthesis.

2. 2,4-Diamino-6-(di-n-propylamino)-5nitrosopyrimidine

18 gm of the crude product 2,4-diamino-6-(di-n-propylamino)-pyrimidine was suspended in 25 ml of water; and glacial acetic acid was added until a pH of 4 was reached. After heating to 50° C. had resulted in solution of the substance, 5.5 gm of sodium nitrite in 10 ml of water were slowly added. After a short time, a raspberry red precipitate was deposited, vacuum filtered, and dried under vacuum at room temperature. The remainder weighed 9.4 gm which was 46% theory; and had a melting point of 206°-208° C.

______________________________________Elemental Analysis:          % C       % H       % N______________________________________Found:         50.40     7.61      35.27Calculated:    49.56     7.62      35.50______________________________________

3. 2,4,5-Triamino-6-(di-n-propylamino)-pyrimidine Dihydrochloride

6.5 gm of 2,4-diamino-6-(di-n-propylamino)-5-nitrosopyrimidine in 150 ml of ethanol with 0.5 gm of catalyst (10% palladium-on-charcoal) were introduced into a pressure-tested hydrogenation vessel to be hydrogenated at room temperature in a catalytic apparatus of the shaker type. After H2 -absorption had terminated, the catalyst was removed by filtration; the solution was acidified with hydrochloric acid, and concentrated. The residue was 5.6 gm which was 78.8% of theory of brown crystals; melting point (decomp.) was 105° C. The mass spectrum showed the molecular mass to be 224 (calcd.: 224).

EXAMPLE 3 Preparation of 2,4,5-Triamino-6-morpholino-pyrimidine Sulfate, C8 H14 N6 O·H2 SO4

2,4,5-Triamino-6-morpholino-pyrimidine sulfate was prepared stepwise from the following compounds:

1. 2,4-Diamino-6-morpholinopyrimidine

2,4-diamino-6-chloropyrimidine was prepared according to Roth et al, J. Amer. Chem. Soc. 72, 1914 (1950). To 10 gm of this compound, (0.07 mol), 30 gm of morpholine (30 ml, 0.34 mol) were added; and while stirring, the mixture was heated to 100° C. within one hour. The mixture was kept at this temperature for 21/2 hours. Then, 10 ml of ethanol were added; and the mixture was stored in a refrigerator until morpholine hydrochloride had precipitated. After removal of this salt, the filtrate was concentrated to produce the crude product which was half oily, half crystalline residue. There was 5.9 gm which constituted 43.7% of theory; and this crude product was utilized for subsequent synthesis.

2. 2,4-Diamino-6-morpholine-5-nitroso-pyrimidine

5.9 gm of the crude 2,4-diamino-6-morpholino-pyrimidine (0.03 mol), were dissolved by heating in 25 ml of water; and glacial acetic acid was added until a pH of 4 was reached. Then the solution was heated to 80° C., and a solution of 2 gm of sodium nitrite in 5 ml of water was slowly added. After a short time, the nitroso compound was obtained as a raspberry red precipitate. Concentration and cooling produced a total yield of a 4.1 gm which was 60.3% of theory. The melting point was 231°-233° C.

______________________________________Elemental Analysis:          % C       % H       % N______________________________________Found:         42.85     5.39      37.48Calculated:    41.92     4.97      38.22______________________________________

3. 2,4,5-Triamino-6-morpholino-pyrimidine Sulfate

2.5 gm of 2,4-diamino-6-morpholino-5-nitroso-pyrimidine was suspended in 15 ml of water, and 2 N HCl (5 ml) was added until the substance just dissolved. The mixture was heated to 50° C.; and sodium dithionite (Na2 S2 O4) was added until the violet color solution took on a yellow color. Then, the solution was filtered, cooled, and adjusted to a pH 2 by means of sulfuric acid (1:1). After a short time, the pyrimidine derivative precipitated as pyrimidine sulfate; the yield was 2.6 gm which was 76.4% of theory.

______________________________________Elemental Analysis(of the recrystallized compound):                 % C     % H    % N______________________________________Found:                31.17   5.23   27.2Calculated:           29.81   4.98   27.8Melting Point: the compound sintered at 230°slow decomposition from 255° C. on.______________________________________

Melting Point: the compound sintered at 230° slow decomposition from 255° C. on.

The other tetraaminopyrimidines which were used in the following Examples were reported in the literature and were prepared by the synthesis indicated in the monograph of D. J. Brown, "The Pyrimidines" in the series of Heterocyclic Compounds, Interscience Publishers, 1962, Vols. I and II.

Several m-aminophenol derivatives which were used as blue-coupling components in the hair coloring preparations according to the invention are novel and are not found in the literature. Hence, their preparation is described in the following examples.

EXAMPLE 4 3-(Diethylamino)-4-methoxyphenol Hydrochloride

8.3 gm ethyl bromide were added to a solution of 10.5 gm of 3-amino-4-methoxyphenol in 50 ml of ethanol. The reaction mixture was refluxed for 24 hours. After the solution had cooled, it was diluted with 800 ml of water; and the pH was adjusted to slight alkalinity by the addition of sodium carbonate. The solution was repeatedly extracted with ether, and the combined extracts were dried over anhydrous sodium sulfate. After the precipitate had been filtered off, the residue was concentrated; and the remaining residue as dissolved in 50 ml of ethanol. Then, after 8.7 gm of ethyl bromide had been added, the alkylation and treatment of the product were repeated as described above with the exception that this time, the dried ether extract was only concentrated to a volume of about 300 ml and dry HCl gas was passed into the solution while it was being cooled with ice. The precipitate was vacuum filtered; the residue was dried, dissolved in ethanol, and treated with active charcoal. Addition of ether to the ethanolic solution resulted in the precipitation of the pure product, which had a melting point of 197°-198° C.

______________________________________Elemental Analysis:        % C      % H      % N    C1______________________________________Found:       57.1     7.8      6.03   15.3Calculated:  56.3     7.8      5.4    14.6______________________________________

Mass Spectrum: 195 (calcd.: 195).

EXAMPLE 5 5-(Ethylamino)-2-methylphenol

88.6 gm of ethyl bromide were added to a solution of 50 gm of 5-amino-2-methylphenol in 250 ml of ethanol; and the mixture was refluxed for four hours. After the solution had cooled, it was diluted with 1.2 liters of water and was made weakly alkaline with sodium carbonate. After repeated extraction with ether, the ether extracts were dried and concentrated. The residue was recrystallized from ethanol, and had a melting point of 128° C. to 129° C.

______________________________________Elemental Analysis:          % C        % H      % N______________________________________Found:         71.5       8.6      9.3Calculated:    70.79      8.51     9.5______________________________________

Mass Spectrum: 151 (calcd.: 151)

EXAMPLE 6 5-(Diethylamino)-2-methylphenol Hydrochloride

5 gm of 5-(ethylamino)-2-methylphenol were dissolved in 50 ml of ethanol, then alkylated analogously to the procedure described in Example 4 with 5,2 gm ethyl bromide, and worked up. The hydrochloride had a melting point of 192° C.

______________________________________Elemental Analysis:       % C        % H      % N    % Cl______________________________________Found:      61.3       8.4      6.5    16.5Calculated: 62.9       8.8      6.8    15.9______________________________________

Mass Spectrum: 179 (calcd.: 179)

The hair dyes according to the invention were applied in form of an aqueous preparation such as an emulsified cream. The emulsion contained

10 parts by weight of fatty alcohols having 12 to 18 carbon atoms,

10 parts by weight of fatty alcohol sulfate (sodium salt) having 12 to 18 carbon atoms and

75 parts by weight of water.

Into each emulsion, there was incorporated 0.01 mol of the tetraaminopyrimidines and couplers which are listed in the following Table I. Then, the pH-value of the emulsion was adjusted to 9.5 with ammonia, and the emulsion was made up to 100 parts by weight with water. The oxidative coupling was effected by using as an oxidizing agent either atmospheric oxygen, or a 1% hydrogen peroxide solution with the proviso that 10 parts by weight of hydrogen peroxide solution were added to 100 parts by weight of the emulsion. The respective dyeing cream, with or without additional oxidizing agent, was applied to human hair that was 90% gray and that had not been pretreated in a special manner. After the cream had remained on the hair for 30 minutes to complete the dyeing process, the hair was washed with a customary shampoo and then dried. The shades thereby obtained are also listed in the following Table I.

                                  TABLE 1__________________________________________________________________________                             Shade obtained                             With                             Atmos- withExample  Developer    Coupler       pheric O2                                    1% H2 O2__________________________________________________________________________7      2,4,5,6-Tetra-amino-               m-Phenylenediamine                             olive  olive  pyrimidine8      2,4,5,6-Tetra-amino-               2,4-Diaminoanisole                             dark green                                    dark green  pyrimidine9      2,4,5,6-Tetra-amino-               m-diamino toluene                             yellowish                                    yellowish  pyrimidine                             brown  brown10     2,4,5,6-Tetra-amino-               m-aminophenol violet violet  pyrimidine                 brown  brown11     2,4,5,6-Tetra-amino-               Resorcinol    strawberry                                    grayish  pyrimidine                 red    red12     2,4,5,6-Tetra-amino-               3-Amino-1-phenyl-                             brownish                                    brownish  pyrimidine   pyrazolone-5  orange orange13     2,4,5,6-Tetra-amino-               3-Methyl-1-phenyl-                             brownish                                    brownish  pyrimidine   pyrazolone-5  red    orange14     2,4,5,6-Tetra-amino-               Resorcinol    golden golden  pyrimidine   monomethyl ether                             brown  brown15     2,4,5,6-Tetra-amino-               Naphthol      yellowish                                    yellowish  pyrimidine                 brown  brown16     2,4,5,6-Tetra-amino-               1,5-Dihydroxy-                             havanna                                    havanna  pyrimidine   Naphthalene   brown  brown17     2,4,5,6-Tetra-amino-               1,7-Dihydroxy-                             olive  olive  pyrimidine   Naphthalene   brown  brown18     4-Dimethylamino-               m-Phenylenediamine                             yellowish                                    yellowish  2,5,6-Triamino-            brown  brown  pyrimidine19     4-Dimethylamino-               2,4-Diaminoanisole                             olive  olive  2,5,6-Triamino-            yellow yellow  pyrimidine20     4-Dimethylamino-               m-Diaminotoluene                             yellowish                                    yellowish  2,5,6-Triamino-            brown  brown  pyrimidine21     4-Dimethylamino-               m-Aminophenol burgundy                                    burgundy  2,5,6-Triamino-            red    red  pyrimidine22     4-Dimethylamino-               Resorcinol    brownish                                    brownish  2,5,6-Triamino-            red    red  pyrimidine23     4-Dimethylamino-               3-Amino-1-Phenyl-                             raspberry                                    raspberry  2,5,6-Triamino-               pyrazolone-5  red    red  pyrimidine24     4-Dimethylamino-               m-Phenylenediamine                             olive  olive  2,5,6-Triamino-            brown  brown  pyrimidine25     2-Dimethylamino-               m-Phenylenediamine                             dark   dark  4,5,6-triamino-            green  green  pyrimidine26     2-Dimethylamino-               2,4-Diaminoanisole                             dark   dark  4,5,6-triamino-            green  green  pyrimidine27     2-Dimethylamino-               m-Diaminotoluene                             olive- olive-  4,5,6-triamino-            tinged tinged  pyrimidine                 yellow yellow28     2-Dimethylamino-               m-Aminophenol grayish                                    dark  4,5,6-triamino-            violet violet  pyrimidine29     2-Dimethylamino-               Resorcinol    reddish                                    reddish  4,5,6-triamino-            violet violet  pyrimidine30     2-Dimethylamino-               3-Amino-1-phenyl-                             brick red                                    brick red  4,5,6-triamino-               pyrazolone-5  pyrimidine31     2-Dimethylamino-               3-Methyl-1-phenyl-                             lake red                                    grayish  4,5,6-triamino-               pyrazolone-5         orange  pyrimidine32     2-Dimethylamino-               Naphthol      hair   olive  4,5,6-triamino-            brown  brown  pyrimidine33     2-Dimethylamino-               3-acetoacetylamino-                             yellowish                                    brass  4,5,6-triaminio-               1-amino-4-nitroben-                             brown  yellow  pyrimidine   zene34     2-Dimethylamino-               1-Phenyl-3,5-pyra-                             brownish                                    gray red  4,5,6-triamino-               zolidine-dione                             orange  pyrimidine35     2-Dimethylamino-               o-Cresol      brownish                                    ivory  4,5,6-triamino-            orange  pyrimidine36     2-Dimethylamino-               m-Cresol      brownish                                    ivory  4,5,6-triamino-            orange  pyrimidine37     2-Dimethylamino-               2,5-Dimethylphenol                             brownish                                    grayish  4,5,6-triamino-            red    green  pyrimidine38     2-Dimethylamino-               3,4-Dimethylphenol                             brownish                                    grayish  4,5,6-triamino-            orange green  pyrimidine39     2-Dimethylamino-               3,5-Dimethylphenol                             brownish                                    grayish  4,5,6-triamino-            orange orange  pyrimidine40     2-Dimethylamino-               1,5-Dihydroxy-                             brown  brown  4,5,6-triamino-               Naphthalene  pyrimidine41     2-Dimethylamino-               Pyrogallol    chocolate                                    zinc  4,5,6-triamino-            brown  gray  pyrimidine42     2-Dimethylamino-               Pyrocatechol  reddish                                    fallow  4,5,6-triamino-            brown  pyrimidine43     2-Dimethylamino-               7-(Dimethylamino)-4-                             grayish                                    golden  4,5,6-triamino-               hydroxy-1-methyl-2-                             orange blond  pyrimidine   quinolone44     2-Dimethylamino-               5-Amino-2-methyl-                             brown  brown  4,5,6-triamino-               phenol  pyrimidine45     2-Dimethylamino-               Hydroquinone  brownish                                    golden  4,5,6-triamino-            red    blond  pyrimidine46     2-Piperidino-               m-Phenylenediamine                             dark   dark  4,5,6-triamino-            green  green  pyrimidine47     2-Piperidino-               m-Aminophenol dark   dark  4,5,6-triamino-            violet violet  pyrimidine48     2-Piperidino-               Resorcinol    grayish                                    grayish  4,5,6-triamino-            ruby   ruby  pyrimidine49     2-Piperidino-               2,4-Diaminoanisole                             dark   dark  4,5,6-triamino-            green  green  pyrimidine50     2-Piperidino-               m-Diaminotoluene                             brownish                                    brownish  4,5,6-triamino-            orange orange  pyrimidine51     2-Piperidino-               3-Amino-1-phenyl-                             tomato tomato  4,5,6-triamino-               pyrazolone-5- red    red  pyrimidine52     2-Morpholino-               m-Phenylenediamine                             olive  olive  4,5,6-triamino  pyrimidine53     2-Morpholino-               m-Aminophenol dark   dark  4,5,6-triamino-            violet violet  pyrimidine54     2-Morpholino-               Resorcinol    grayish                                    grayish  4,5,6-triamino-            ruby   ruby  pyrimidine55     2-Morpholino-               2,4-Diaminoanisole                             dark   dark  4,5,6-triamino-            green  green  pyrimidine56     2-Morpholino-               m-Diaminotoluene                             olive  olive  4,5,6-triamino-            brown  brown  pyrimidine57     2-Morpholino-               3-Amino-1-phenyl-                             brownish                                    brownish  4,5,6-triamino-               pyrazolone-(5)                             red    red  pyrimidine58     2-Methylamino-               m-Phenylenediamine                             olive  olive  4,5,6-triamino-  pyrimidine59     2-Methylamino-               m-Aminophenol dark   dark  4,5,6-triamino-            purple violet  pyrimidine60     2-Methylamino-               Resorcinol    grayish                                    brownish  4,5,6-triamino-            red    violet  pyrimidine61     2-Methylamino-               2,4-Diaminoanisole                             dark   dark  4,5,6-triamino-            green  green  pyrimidine62     2-Methylamino-               m-Diaminotoluene                             yellow yellow  4,5,6-triamino-  pyrimidine63     2-Methylamino-               3-Amino-1-phenyl-                             brownish                                    brownish  4,5,6-triamino-               pyrazolone-5  red    red  pyrimidine64     6-Morpholino-               m-Phenylenediamine                             olive  olive  2,4,5-triamino-            brown  brown  pyrimidine65     6-Morpholino-               2,4-Diaminoanisole                             grayish                                    olive  2,4,5-triamino-            green  pyrimidine66     6-Morpholino-               m-Diaminotoluene                             golden brass  2,4,5-triamino-            yellow yellow  pyrimidine67     6-Morpholino-               m-Aminophenol grayish                                    grayish  2,4,5-triamino-            ruby   red  pyrimidine68     6-Morpholino-               Resorcinol    brownish                                    brownish  2,4,5-triamino-            red    red  pyrimidine69     6-Morpholino-               3-Amino-1-phenyl-  2,4,5-triamino-               pyrazolone-5  dull red                                    dull red  pyrimidine70     6-Piperidino-               m-Phenylenediamine                             bamboo grayish  2,4,5-Triamino-            yellow yellow  pyrimidine71     6-Piperidino-               2,4-Diaminoanisole                             olive  olive  2,4,5-Triamino-            brown  pyrimidine72     6-Piperidino-               m-Aminophenol olive  bamboo  2,4,5-Triamino-            brown  yellow  pyrimidine73     6-Piperidino-               Resorcinol    grayish                                    ivory  2,4,5-Triamino-            red  pyrimidine74     6-Piperidino-               m-Diaminotoluene                             grayish                                    olive  2,4,5-Triamino-            yellow brown  pyrimidine75     6-Piperidino-               3-Amino-1-phenyl-                             chamois                                    straw  2,4,6-Triamino-               pyrazolone-5  yellow yellow  pyrimidine76     6-(Di-n-propylamino)-               m-Phenylenediamine                             honey  olive  2,4,5-triamino-            yellow  pyrimidine77     6-(Di-n-propylamino)-               2,4-Diaminoanisole                             olive  olive  2,4,5-triamino-            green  pyrimidine78     6-(Di-n-propylamino)-               m-Diaminotoluene                             honey  honey  2,4,5-triamino-            yellow yellow  pyrimidine79     6-(Di-n-propylamino)-               m-Aminophenol grayish                                    grayish  2,4,5-triamino-            ruby   ruby  pyrimidine80     6-(Di-n-propylamino)-               Resorcinol    brownish                                    brownish  2,4,5-triamino-            red    red  pyrimidine81     6-(Di-n-propylamino)-               3-Amino-1-phenyl-                             reddish                                    reddish  2,4,5-triamino-               pyrazolone-5- brown  brown  pyrimidine82     5-Amino-2,4,6-               m-Phenylenediamine                             oak brown                                    olive  tris-(methylamino)-  pyrimidine83     5-Amino-2,4,6-               2,4-Diaminoanisole                             olive  beaver  tris-(methylamino)-               brown  pyrimidine84     5-Amino-2,4,6-               m-diaminotoluene                             brass  olive  tris-(methylamino)-        yellow  pyrimidine85     5-Amino-2,4,6-               m-Aminophenol dark   brown  tris-(methylamino)-        ruby  pyrimidine86     5-Amino-2,4,6-               Resorcinol    grayish                                    dull  tris-(methylamino)-        red    red  pyrimidine87     5-Amino-2,4,6-               3-Amino-1-phenyl                             reddish                                    light  tris-(methylamino)-               pyrazolone-5  brown  brown  pyrimidine88     2-Dimethylamino-               3-(Diethylamino)-                             blue   blue  4,5,6-Triamino-               phenol        black  black  pyrimidine89     2-Dimethylamino-               3-[(β-Hydroxyethyl)-                             blue   blue  4,5,6-Triamino-               amino]-phenol black  black  pyrimidine90     2-Dimethylamino-               3-[2-(Diethylamino)-                             blue   blue  4,5,6-Triamino-               ethyl-amino]-phenol                             black  black  pyrimidine91     2-Dimethylamino-               3-Morpholino-phenol                             dark   dark  4,5,6-Triamino-            violet violet  pyrimidine92     2-Dimethylamino-               3-(Ethylpropylamino)                             blue   blue  4,5,6-Triamino-               phenol        black  black  pyrimidine93     2-Dimethylamino-               3-(Butylamino)-phenol                             blue   blue  4,5,6-Triamino-            black  black  pyrimidine94     2-Dimethylamino-               3-(Ethylamino)-phenol                             blue   blue  4,5,6-Triamino-            black  black  pyrimidine95     2-Dimethylamino-               3-(Octylamino)-phenol                             dark   dark  4,5,6-Triamino-            violet violet  pyrimidine96     2-Dimethylamino-               3-Pyrrolidino-phenol                             blue   blue  4,5,6-Triamino-            black  black  pyrimidine97     2-Dimethylamino-               3-Piperidino-phenol                             dark   dark  4,5,6-Triamino-            blue   blue  pyrimidine98     2-Dimethylamino-               3-(Dimethylamino)-                             dark   dark  4,5,6-Triamino-               phenol        blue   blue  pyrimidine99     2-Dimethylamino-               5-(Ethylamino)-2-                             bluish bluish  4,5,6-Triamino-               methyl-phenol gray   gray  pyrimidine100    2-Dimethylamino-               2-Chloro-5-(dimethyl-                             dark   dark  amino)-phenol               amion)-phenol violet violet  pyrimidine101    2-Dimethylamino-               3-Hydroxydiphenyl-                             dark   dark  4,5,6-Triamino-               amine         blue   blue  pyrimidine102    2-Dimethylamino-               3-(Methylenecyana-                             dark   dark  4,5,6-Triamino-               mido)-phenol  violet violet  pyrimidine103    2-Dimethylamino-               2-bromo-5-(methylene-                             blue   blue  4,5,6-Triamino-               cyanamido)-phenol                             black  black  pyrimidine104    2-Dimethylamino-               3-Tihoureido-phenol                             brownish                                    dull  4,5,6-Triamino-            gray   violet  pyrimidine105    2-Dimethylamino-               3-(Diethylamino)-4-                             dark   dark  4,5,6-Triamino-               methoxy-phenol                             blue   blue  pyrimidine106    2-Dimethylamino-               5-(Diethylamino)-2-                             dark   dark  4,5,6-Triamino-               methyl-phenol blue   blue  pyrimidine107    2-Morpholino-               m-Dimethylamino-                             dark   dark  4,5,6-triamino-               phenol        blue   blue  pyrimidine108    2-Morpholino-               3-Hydroxydiphenyl-                             dark   dark  4,5,6-triamino-               amine         blue   blue  pyrimidine109    2-Morpholino-               3-(Octylamino)-                             dark   violet  4,5,6-triamino-               phenol        violet blue  pyrimidine110    2-Piperidino-               m-(Dimethylamino)-                             dark   dark  4,5,6-triamino-               phenol        blue   blue  pyrimidine111    2-Piperidino-               m-(Octylamino)-                             blue   blue  4,5,6-triamino-               phenol        violet violet  pyrimidine112    2-Piperidino-               3-Hydroxydiphenyl-                             dark   dark  4,5,6-triamino-               amine         blue   blue  pyrimidine113    2-Methylamino-               3-Hydroxydiphenyl-                             violet blue  4,5,6-triamino-               amine         blue   violet  pyrimidine114    2-Methylamino-               3-(Octylamino)-                             deep   deep  4,5,6-triamino-               phenol        violet violet  pyrimidine115    2-Methylamino-               m-(Dimethylamino)-                             deep   violet  4,5,6-triamino-               phenol        violet blue  pyrimidine116    2,4,5,6-Tetraamino-               m-(Dimethylamino)-                             dark   dark  pyrimidine   phenol        violet violet117    2,4,5,6-Tetraamino-               m-(Diethylamino)-                             dark   dark  pyrimidine   phenol        violet violet118    2,4,5,6-Tetraamino-               m-(Ethylamino)-                             indigo indigo  pyrimidine   phenol        blue   blue119    2,4,5,6-Tetraamino-               m-(Ethylpropylamino)-                             dark   dark  pyrimidine   phenol        violet violet120    2,4,5,6-Tetraamino-               m-[(β-Hydroxyethyl)-                             dark   dark  pyrimidine   amino]-phenol violet violet121    2,4,5,6-Tetraamino-               m-Piperidino-phenol                             light  light  pyrimidine                 violet violet122    2,4,5,6-Tetraamino-               m-Pyrrolidino-                             violet violet  pyrimidine   phenol123    2,4,5,6-Tetraamino-               3-Hydroxydiphenyl-                             indigo indigo  pyrimidine   amine         blue   blue__________________________________________________________________________

The following tests were conducted to determine the toxicological and dermatological properties of tetraaminopyrimidines. The test compound used was 2-dimethylamino-4,5,6-triamino-pyrimidine sulfate which was compared with known compounds, p-phenylenediamine and p-toluylenediamine sulfate. The following results were obtained.

EXAMPLE 124 Acute Toxicity

Male white mice of the CF/W 68-strain were used for the tests of general tolerance. The average weight of the test animals was 22 gm. The substances to be tested were administered by means of a stomach tube, whereby increasing dosages were used once. Ten mice were employed per dose. The volume of application was constant and was 0.2 cm3 /10 gm body weight. The animals were observed for a period of eight days. After the test results had been calculated according to the method of Litchfield-Wilcoxon, J. Pharm. Exptl. Ther. 96, 99-108(1949), the following LD50 -values were obtained.

______________________________________2-dimethylamino-4,5,6-triamino-pyrimidine sulfate                      555 mg/kgp-Phenylendiamine           87 mg/kgp-Diaminotoluene Sulfate   110 mg/kg______________________________________

Distilled water was used as the solvent.

EXAMPLE 125 Dermal Tolerance Tests of the Hairless Mouse

Groups of five animals were used for each preparation. Small quantities of the substances to be tested were applied in form of an aqueous 5% solution to the dorsal skin of each animal. A single daily application was continued for 14 days. During this period, and at the end of the test, none of the animals showed any reaction.

EXAMPLE 126 Mucocutaneous Tolerance of the Rabbit Eye

Groups of albino rabbits were employed for these tests of the local tolerance. Small quantities of the substances to be tested were employed as aqueous 5% preparations; and were once dripped into the conjunctival sac of one eye of each rabbit. The reactions of the mucous membranes of the eye were evaluated according to the point system of Draize, [Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics. Assoc. of Food and Drug Officials of the U.S., pp. 49-52 (1959)]. This evaluation which was made 2, 6, 24 and 48 hours after the application and it showed that p-phenylenediamines leads to a low-grade redness and exudation of the conjuctiva which could not be detected 24 hours after the dripping in. The other two test compounds were tolerated without reaction.

EXAMPLE 127 Skin (Tissue) Tolerance Test of White Mice after a Single Intracutaneous Application of Various Concentrations of the Preparations to be Tested

This test of local tolerance was conducted according to Barail, [J. Society Cosmetic Chemists 11, 241 (1960)]. In this test, small quantities of the compounds to be tested were transcutaneously applied to the abdominal skin of white mice, whereby increasing concentration were used. After 24 hours, the test animals were sacrificed and the treated places of the skin were cut out and dried. The skin damages were evaluated according to a point system, in which the blood irrigation and other damages of the treated skin are taken into account. In this test, a larger animal group of ten mice was employed per preparation and per test concentration. Hence, finer differences with respect to local tolerance could be observed according to the above-described test procedure. The test results are reported in the following Table II. ##STR8##

It is evident from the above test results that (2-dimethylamino)-4,5,6-triamino-pyrimidine sulfate shows the best results of the tested developers with respect to general and local tolerance. Besides these good toxicological and dermatological properties, the tetraaminopyrimidines used .[.into.]. .Iadd.in .Iaddend.the hair coloring preparations according to the invention have the additional advantages that the color can readily be developed with atmospheric oxygen. These hair coloring preparations produce an extraordinary variation of shades which are distinguished by excellent fastness to light and washing, as well as by excellent resistance to abrasion, and they can easily be removed with reducing agents.

Although the present invention has been disclosed in connection with a few preferred embodiments thereof, variations and modifications may be resorted to by those skilled in the art without departing from the principles of the new invention. All of these variations and modifications are considered to be within the true spirit and scope of the present invention as disclosed in the foregoing description and defined by the appended claims.

Citas de patentes
Patente citada Fecha de presentación Fecha de publicación Solicitante Título
US2350812 *21 Nov 19426 Jun 1944Eastman Kodak CoDiketopyrimidine coupler
US2355691 *21 Nov 194215 Ago 1944Eastman Kodak CoPyrimidine couplers
US3359168 *3 Ago 196619 Dic 1967Warner Lambert PharmaceuticalDyeing hair with 2, 3, 6-triaminopyridine and salts thereof
US3536436 *6 Jul 196627 Oct 1970Hans SchwarzkopfHair dyeing composition and method
Citada por
Patente citante Fecha de presentación Fecha de publicación Solicitante Título
US5176716 *21 May 19915 Ene 1993Goldwell AgHydroxytriaminopyrimidine developer
US62281303 Nov 19988 May 2001Bristol-Myers Squibb Company1-(2,5-diaminophenyl)ethylene glycol; water soluble; p-phenylenediamine replacement
US634207927 Ene 200029 Ene 2002Bristol-Myers Squibb CompanyPrimary intermediate for use in oxidative hair dyeing
US70449876 Oct 200316 May 2006L'oreal S.A.6-alkoxy-2,3-diaminopyridine couplers in which the amino radical in position 2 is a monosubstituted amino radical, and use of these couplers for dyeing keratin fibres
US708114023 Abr 200425 Jul 2006Henkel Kommanditgesellschaft Auf Aktien (Henkel Kgaa)Developer components and their use for dyeing keratinic fibers
US713254329 Mar 20047 Nov 2006L'oreal S.A.Para-phenylenediamine derivatives containing a disubstituted pyrrolidinyl group bearing a cationic radical, and use of the same for dyeing keratin fibers
US713504621 Jun 200414 Nov 2006L'oreal S.A.Dye composition comprising at least one oxidation base chosen from 4,5-diamino-1-(β-hydroxyethyl)-1H-pyrazole and 4,5-diamino-1-(β-methoxyethyl)-1H-pyrazole and the addition salts thereof and at least one coupler chosen from 6-hydroxyindole and the addition salts thereof
US713504712 Dic 200314 Nov 2006Henkel Kommanditgesellschaft Auf Aktien (Henkel Kgaa)N-2-(morpholine-4-yl)ethyl-m-phenylenediamine, N-3-(morpholine-4-yl)propyl-m-phenylenediamine, and N-3-(imidazole-1-yl)-propyl-m-phenylenediamine; high color intensities, good light fastness and washing fastness properties, and a good equalization capability
US714767221 Oct 200312 Dic 2006L'oreal S.A.Dyeing human hair
US715333120 Dic 200226 Dic 2006L'oreal S.A.Dyeing composition for keratinous fibers comprising an oxyethylene rapeseed fatty acid amide
US716919423 Dic 200330 Ene 2007L'oreal S.A.Dye composition comprising at least one particular tricationic direct dye, dyeing process, use and multi-compartment devices
US718627623 Dic 20036 Mar 2007L'orealHair coloring; permanent, strong; light, weather, washing, perspiration and rubbing resistance; simultaneously lightens fibers for blended, uniform look; kits
US720858623 Jun 200524 Abr 2007L'oreal S.A.Azo dye one and azo dye two are linked with a linking chain and both dyes conatin a cationic heteroaromatic ring
US721111923 Jun 20051 May 2007Henkel Kommanditgesellschaft Auf Aktien (Henkel Kgaa)Coupling components
US72172997 Ene 200515 May 2007L'oreal S.A.direct dyes, for obtaining satisfactory color uptake on keratin fibers, irrespective of their degree of sensitization, and for allowing access to natural, very strong, sparingly selective colorations in varied dark shades, which show a very good level of fastness and which don't change color over time
US724771315 Dic 200524 Jul 2007L'oreal, S.A.For the dyeing of keratin
US727608729 Abr 20042 Oct 2007L'oreal S.A.Dye composition comprising 2-chloro-6-methyl-3-aminophenol as coupler, para-aminophenol and 3-methyl-4-aminophenol as oxidation bases and at least one associative thickening polymer
US728206923 Jun 200516 Oct 2007L'oreal S.A.Azo dye one and azo dye two are linked with a linking chain and both dyes conatin a cationic heteroaromatic ring
US728513823 Jun 200523 Oct 2007L'oreal, S.A.Mixture of unsymmetrical diazo dyes with heteraromatic and aryl radicals, acids, and a cosmetically acceptable anion; dyeing human hair
US728812223 Jun 200530 Oct 2007L'oreal S.A.Cationic diazo compounds, compositions comprising them as direct dye, process for dyeing keratin fibers and device therefor
US728863915 Dic 200530 Oct 2007L'oreal S.A.Dyssymmetrical diazo compounds having at least one 4-pyridinium unit and a cationic or non-cationic linker, compositions comprising them, method of coloring, and device
US730047029 Abr 200427 Nov 2007L'oreal S.A.Oxidative hair dye
US730663029 Abr 200411 Dic 2007L'oreal S.A.Composition comprising at least one coupler chosen from 2-chloro-6-methyl-3-aminophenol and addition salts thereof, at least one oxidation base, and at least one associative polymer comprising at least one C8-C30 fatty chain
US732301521 Oct 200329 Ene 2008L'oreal S.A.Dyeing human hair
US73262568 Dic 20035 Feb 2008L'ORéAL S.A.dyeing human hair; aqueous solution
US732625922 Jun 20055 Feb 2008L'oreal S.A.Use of polycationic compounds in the dyeing of keratinous fibres
US73292878 Dic 200312 Feb 2008L'oreal S.A.Oxidation dye composition for keratin fibers, comprising at least one oxidation dye, at least one associative polymer, at least one nonionic cellulose-based compound not comprising a C8-C30 fatty chain, and at least one cationic polymer with a charge density of greater than 1 meq/g and not comprising a C8-C30 fatty chain
US732928828 Feb 200512 Feb 2008L'oreal S.A.N-heteroaryl secondary para-phenylenediamine, a dye composition comprising such a para-phenylenediamine, a process for preparing this composition and use thereof
US733853628 Feb 20054 Mar 2008L'oreal S. A.N-[3-(4-methylpiperazin-1-yl)propyl]benzene-1,4-diamine; very powerful, sparingly selective and fast, such as light-fast, dyeing of keratin fibers, while avoiding fiber degradation
US734787928 Feb 200525 Mar 2008L'Oreál, S.A.Sulfur-containing secondary para-phenylenediamines dye compositions comprising such para-phenylenediamines, processes, and uses thereof
US735126715 Dic 20051 Abr 2008L'oreal S.A.Symmetrical diazo compounds comprising 2-imidazolium groups and a non-cationic linke, compositions comprising them, method of coloring, and device
US73544593 Nov 20058 Abr 2008L'oreal S.A.Use of organosilane compounds for dyeing keratin fibers
US73745811 May 200620 May 2008L'oreal, S.A.quinolinium; hair dye; dyeing under mild conditions without strong oxidizer, but as colorfast as oxidation dyes
US738443228 Feb 200510 Jun 2008L'oreal S.A.Secondary para-phenylenediamines having a carboxyl group, dye compositions comprising the same, and dyeing processes using the compositions
US739636815 Dic 20058 Jul 2008L'oreal S.A.For dyeing keratin fibers; tinctorial strength and wash resistance, perspiration resistance
US740751723 Ago 20065 Ago 2008L'oreal S.A.Cationic azo dyes with julolidine units, dyeing composition containing them, method of dyeing
US741358029 Jun 200619 Ago 2008L'oreal S.A.E.g., 2,6-bis[4-(aminophenyl)amino]heptanedioic acid 4HCl and 2,6-bis[(4-amino-phenyl)amino]hexanamide 4HCl; useful as oxidation bases for the dyeing of keratin fibers to produce strong, aesthetic shades with low selectivity
US742260929 Jun 20069 Sep 2008OrealDouble para-phenylenediamines joined by an aromatic group for dyeing keratin fibers
US742927828 Sep 200730 Sep 2008L'oréalN-(2-Thiophen-2-ylethyl)benzene-1,4-diamine; hair dye; very strong and sparingly selective coloration of keratin fibers, light fast, avoiding the degradation of the fibers
US743526728 Feb 200514 Oct 2008L'oreal S.A.N-(2-Methoxy-1-methylethyl)benzene-1,4-diamine; oxydation dyeing of hair
US743526828 Feb 200514 Oct 2008L'oreal S.A.2-[2-(4-aminophenylamino)ethylamino]ethanol dihydrochloride; oxydation dyeing of hair
US743872815 Dic 200521 Oct 2008L'oreal S.A.5-bromo-2-{(E)-[4-(dimethylamino)-2-hydroxyphenyl]diazenyl}-1-[3-(2-{(E)-[4-(dimethylamino)phenyl]diazenyl}pyridinium-1-yl)propyl]pyridinium dibromide; hair dye
US744221511 Ago 200628 Oct 2008L'oreal S.A.Process for coloring keratin fibers comprising treating the scalp with at least one sorbitan ester
US744564528 Feb 20054 Nov 2008L'oreal S.A.Ortho-and/or meta-substituted N-alkylhydroxylated secondary para-phenylenediamine compounds, compositions for dyeing keratin fibers comprising such compounds, and processes of dyeing therewith
US748184727 Mar 200727 Ene 2009L'oreal S.A.Dye composition comprising at least one cationic hydrazone direct dye, dyeing process, and multi-compartment devices
US748515523 Dic 20053 Feb 2009L'oreal S.A.Dyeing hair with an oxidation base and a phenylenediamine having at least one primary amine group and washing the hair with a detergent containing an alkylpolyglycoside or polyglycerolated nonionic surfactant
US748515631 May 20063 Feb 2009L'oreal S.A.Composition for dyeing keratin fibers, comprising at least one diamino-N,N-dihydropyrazolone derivative, at least one coupler and at least one associative polyurethane polymer
US748835531 May 200610 Feb 2009L'oreal S.A.to obtain fast coloration of keratin fibers that is resistant to light and to washing; hair dyes; oxidation base such as 2,3-diamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one dihydrochloride; Hexylene glycol; 2-methyl-5-aminophenol as coupler
US748835631 May 200610 Feb 2009L'oreal S.A.to obtain fast coloration of keratin fibers that is resistant to light and to washing; hair dyes; oxidation base such as 2,3-diamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one dihydrochloride; Hexylene glycol; 2-methyl-5-aminophenol as coupler
US755995617 May 200714 Jul 2009L'oreal S.A.Quaternary pyridinium or benzyltrialkylammonium salts; hair dyes, cosmetics, shampoo
US75788559 Nov 200625 Ago 2009L'ORéAL S.A.2-(3-Amino-pyrazolo[1,5-a]pyridin-2-ylamino)-ethyl]-trimethylammonium chloride;human hair dyes; cationic dyes; pyridine dyes; peroxide additive along with coupling agent;nontoxic; intensity; weaatherproofing; colorfastness; chemical resistance, permanent waves; uniform covering power; stability
US75788569 May 200825 Ago 2009L'oreal S.A.[2-(3-Aminopyrazolo[1,5-a]pyridin-2-ylamino)ethyl]tri-;methylammonium salt; for keratinous fibers, hair; for multi-compartment devices
US758212131 May 20061 Sep 2009L'oreal S.A.Composition for dyeing keratin fibers, comprising at least one diamino-N,N-dihydropyrazolone derivative, at least one coupler, and at least one heterocyclic direct dye
US758212319 Jun 20081 Sep 2009L'oreal S.A.Coloring composition comprising at least one azomethine compound with a pyrazolinone unit
US76353949 Nov 200622 Dic 2009L'oreal S.A.Composition for the dyeing of keratin fibers comprising at least one 3-amino-pyrazolopyridine derivatives
US764530428 Feb 200612 Ene 2010L'oreal S.A.Dyeing of in particular human keratin materials by dry thermal transfer of a direct azomethine dye, composition comprising the said dye and its method of preparation
US76485369 May 200819 Ene 2010L'oreal S.A.Method of coloring keratinous fibers comprising application of at least one aminopyrazolopyridine oxidation base in the absence of chemical oxidizing agents
US765153528 Feb 200626 Ene 2010L'oreal S.A.Applied to hair in the form of a divided solid, in free form on heat-resistant support, not dispersed in a matrix; hair is applied to this support and the whole is heated by smoothing iron or laser
US765153620 Jun 200726 Ene 2010L'oreal S.A.Strong, chromatic, aesthetic, and/or sparingly selective coloring; visible deep red shades which shows good resistance to thevarious attacking factors to which the hair may be subjected, such as shampoo, light, sweat, and/or permanent waves; dyeing grey/white hair
US765153720 Jun 200726 Ene 2010L'oreal S.A.Composition for dyeing keratin fibers, comprising 2,3-diamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, 6-chloro-2-methyl-5-aminophenol and a substituted meta-aminophenol
US765153930 Nov 200726 Ene 2010L'oreal S.A.Dye composition of acidic pH comprising 2,3-diamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, a coupler, a particular surfactant and an oxidizing agent and processes and kits using said composition
US767815717 May 200716 Mar 2010L'oreal S.A.Use of an anionic hydrotrope for the colouring of keratinous fibres, composition comprising it and colouring processes employing it
US772268011 Feb 200625 May 2010L'oreal S.A.Dyeing of human keratin materials by dry thermal transfer of a direct dye, composition comprising the said dye and its method of preparation
US776697730 Nov 20073 Ago 2010L'oreal S.A.Dyeing hair at an acidic pH of 5.5-7.5 using an oxidation base of the title compound, a para-phenylenediamine, a coupler of a meta-aminophenol and an oxidizer to obtain tints in red, coppery or mahogany tones; visibility, strong, chromatic, aesthetic, and/or sparingly selective
US777149121 Dic 200710 Ago 2010L'oreal S.A.Hair dye; environmentally friendly, due to use of nonionic cellulose; good shampoo fastness
US78578649 Oct 200928 Dic 2010L'oreal S.A.Composition for the dyeing of keratin fibers comprising at least one 3-amino-pyrazolopyridine derivative
US791890020 Jun 20075 Abr 2011L'oreal S.A.Process for the predictable dyeing of keratinous fibers comprising applying at least one composition comprising at least one diamino-N, N-dihydropyrazolone derivative and at least one composition chosen from fundamental and/or golden-highlights compositions
US797238711 Ago 20065 Jul 2011L'oreal S.A.Composition for dyeing keratin fibers comprising at least one oxidation base and a polyoxyethylenated sorbitan ester
US799846428 Sep 200616 Ago 2011L'oreal S.A.Process for the photoprotective treatment of artificially dyed keratin fibers by application of a liquid water/steam mixture
US836679211 Ago 20105 Feb 2013L'orealDye composition comprising a heterocyclic oxidation base and an indole coupler
US840399913 Dic 201026 Mar 2013L'orealDyeing and/or bleaching composition comprising a polycondensate of ethylene oxide and propylene oxide
US841980712 Oct 201016 Abr 2013L'orealComposition including a glyceride and an organophosphonic acid or one of the salts thereof, dyeing or colour-lightening method implementing same and devices
US862310014 Dic 20117 Ene 2014L'oreal4-aminoindole derivatives and use thereof for the oxidation dyeing of keratin fibres
US86285867 Dic 201114 Ene 2014L'orealComposition comprising an oxidation dye precursor, a polycondensate of ethylene oxide and propylene oxide and a cationic polymer with a charge density of greater than or equal to 4 meq./g
US86285877 Dic 201114 Ene 2014L'orealComposition comprising an oxidation dye precursor, a polycondensate of ethylene oxide and propylene oxide, and a polyoxyalkylenated fatty acid
US87091016 Dic 201129 Abr 2014L'orealOxidation dye composition comprising a polycondensate of ethylene oxide and of propylene oxide, and an oxyethylenated fatty acid amide
US878450628 Oct 201122 Jul 2014L'orealDye composition having a low content of ammonia
WO1995001713A1 *28 Jun 199419 Ene 1995Henkel KgaaDyes containing tetraaminopyrimidine and direct-dyeing agents
Clasificaciones
Clasificación de EE.UU.8/409
Clasificación internacionalA61Q5/10, A61K8/49
Clasificación cooperativaA61Q5/10, A61K8/4953
Clasificación europeaA61K8/49F2, A61Q5/10