USRE33086E - Process for manufacturing effervescent granules and tablets and high efficiency granulation tower for such process - Google Patents
Process for manufacturing effervescent granules and tablets and high efficiency granulation tower for such process Download PDFInfo
- Publication number
- USRE33086E USRE33086E US07/071,991 US7199187A USRE33086E US RE33086 E USRE33086 E US RE33086E US 7199187 A US7199187 A US 7199187A US RE33086 E USRE33086 E US RE33086E
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- US
- United States
- Prior art keywords
- iaddend
- iadd
- raw materials
- gravity
- granules
- Prior art date
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- Expired - Lifetime
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/16—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by suspending the powder material in a gas, e.g. in fluidised beds or as a falling curtain
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Glanulating (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Detergent Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
______________________________________ Formula of granulation ______________________________________ Paracetamol 28 kg Monosodium carbonate 100 kg Monopotassium carbonate 3.740 kg Sorbitol 25.500 kg Anhydrous citric acid 73.000 kg Ascorbic acid 17.000 kg TOTAL 247.24 kg ______________________________________
______________________________________ Disodium sulfate 20.200 kg Sodium bromide 7.100 kg Disodium phosphate 13.800 kg Monosodium carbonate 101.000 kg Anhydrous citric acid 89.000 kg ______________________________________
______________________________________ Monosodium carbonate 108.000 kg Anhydrous citric acid 14.500 kg Betaine citrate 142.000 kg ______________________________________
Claims (9)
- citric acid..]. .Iadd.10. A process for the manufacture of effervescent tablets from a plurality of powdered raw materials, with the avoidance of external contamination, said process comprising the steps of:(a) storing said powdered raw materials in storage hoppers;(b) transferring said raw materials downwardly by gravity to a granulator-vacuum-dryer device, introducing into said granulator-vacuum dryer device a granulation agent in an amount effective to wet form wet granules and drying under vacuum said wet granules therein to obtain dried granules;(c) evacuating the dried granules by gravity from said granulator-vacuum dryer, transferring them downwardly by gravity to a cooler and cooling said dried granules to a temperature at which destabilization is impeded; and(d) transferring said dried and cooled granules downwardly by gravity to a storage container;said process being carried out in an enclosed vertically arranged apparatus
- array. .Iaddend. .Iadd.11. The process of claim 10, wherein the raw materials are individually subjected to said steps (a), (b) and (c), then mixed together and subjected to direct compression. .Iaddend. .Iadd.12. The process of claim 10, wherein the raw materials are pre-mixed within said granulator-vacuum-dryer device. .Iaddend. .Iadd.13. The process of claim 10, wherein said granulation agent is a solvent selected from the group consisting of demineralized water an aqueous wetting solutions. .Iaddend. .Iadd.14. The process of claim 10, wherein said granulation agent is a solution of dioctylsulfosuccinate in water. .Iaddend.
- .Iadd. The process of claim 10, wherein after drying and cooling, the dried and cooled raw materials are transferred by gravity to a calibration device. .Iaddend. .Iadd.16. The process of claim 15, wherein after calibration, said dried, cooled and calibrated raw materials are transferred by gravity to a band mixer. .Iaddend. .Iadd.17. The process according to claim 10, wherein the raw materials are weighed before any treatment. .Iaddend. .Iadd.18. The process of claim 10, wherein said dryer has a jacket for a heat exchange fluid and during said drying step (b), said raw materials are subjected to mechanical stirring with lump-breaking cutters, a vacuum is created and a granulation agent introduced by aspiration, the temperature being regulated by circulating a heat-exchange fluid in said jacket. .Iaddend. .Iadd.19. The process of claim 10, wherein the raw materials comprise:effervescent mixture:sodium bicarbonatecitric acidand the granulation agent is demineralized water. .Iaddend. .Iadd.20. The process of claim 19, wherein the effervescent mixture contains glycocoll. .Iaddend. .Iadd.21. The process of claim 10, wherein the raw materials comprise:paracetamolmonosodium carbonatemonopotassium carbonatesorbitolanhydrous citric acidascorbic acidand the granulation agent is a solution of sodium dioctylsulfosuccinate in
- water. .Iaddend. .Iadd.22. The process of claim 10, wherein the raw materials in powder form are as follows:calcium carbasalate1ysine carbamatecitric acid .Iaddend. .Iadd.23. The process of claim 10, wherein the raw materials are as follows:calcium carbasalate1ysine carbamatecitric acidaromaPEG (polyethyleneglycol)
- ammonium saccharinate. .Iaddend. .Iadd.24. A process for the manufacture of effervescent tablets from a plurality of powered raw materials, with the avoidance of external contamination, said process comprising the steps of:(a) storing said powdered raw materials in storage hoppers;(b) transferring said raw materials downwardly by gravity to a mixer-granulator-dryer device, mixing said raw materials, introducing into said mixer-granulator-dryer device a granulation agent, mixing the raw materials and the granulation agent under substantially atmospheric pressure for a period of time sufficient to achieve formation of wet granules and drying under vacuum said wet granules in said mixer-granulator-dryer device to obtain dried granules;(c) evacuating the dried granules by gravity from said granulator-vacuum dryer, transferring them downwardly by gravity to a cooler and cooling said dried granules to a temperature at which destabilization is impeded; and(d) transferring said dried and cooled granules downwardly by gravity to a storage container;said process being carried out in an enclosed vertically arranged apparatus
- array. .Iaddend. .Iadd.25. The process of claim 24, wherein the granulation agent is introduced by spraying or by aspiration under partial vacuum. .Iaddend. .Iadd.26. The process of claim 24, wherein there is introduced one to six weight percent of granulation agent. .Iaddend. .Iadd.27. The process of claim 24, which is automated. .Iaddend.
- .Iadd. A vertically disposed apparatus array for the manufacture of effervescent tablets, said apparatus array constituting a tower and comprising in vertically descending order:(a) storage hopper means positioned near the top of said tower for the storage of raw materials;(b) granulation and vacuum drying means including means for introducing a granulation agent to wet form wet granules and means for eliminating humidity from said wet granules to obtain dried granules;(c) cooling means for lowering the temperature of said dried granules, and(d) at least one storage container for dried and cooled granules:said apparatus comprising also means for feeding material by gravity from said storage hopper means to said granulation-vacuum drying means, means for evacuating said dried granules by gravity from said granulation-vacuum-drying means and feeding them by gravity to said cooling means, and means for transferring granules by gravity from said cooling means to said storage container or containers. .Iaddend.
- .Iadd. The apparatus of claim 28, further comprising calibrating means for calibrating the materials after they leave said cooler. .Iaddend. .Iadd.30. The apparatus of claim 29, further comprising a band mixer for mixing the materials after they leave said calibrating means. .Iaddend. .Iadd.31. The apparatus of claim 30, further comprising weighing means for weighing said raw materials before any treatment. .Iaddend. .Iadd.32. The apparatus of claim 29, wherein said drying device comprises mixing means comprising a system of mechanical stirring with lump-breaking cutters, means for introducing a granulation agent by creation of a vacuum or a spraying system supplied by a pump, means for regulating the temperature comprising a double jacket for circulating heat-exchange fluid, and vacuum means for creating vacuum. .Iaddend. .Iadd.33. A vertically disposed apparatus array for the manufacture of effervescent tablets, said apparatus array constituting a tower and comprising in vertically descending order:(a) storage hopper means positioned near the top of said tower for the storage of raw materials;(b) a mixer-granulator-dryer device having mixing means, means for introducing a granulation agent, means for subjecting said mixer-granulator-dryer device to substantially atmospheric pressure at least during granulation and means for eliminating humidity from said wet granules material under vacuum to obtain dried granules;(c) cooling means for lowering the temperature of the dried granules, and(d) at least one storage container for dried and cooled granules;said apparatus comprising also means for feeding material by gravity from said storage hopper means to said mixer-granulator-dryer device, means for evacuating said dried granules by gravity from said mixer-granulator-dryer device and feeding them by gravity to said cooling means, and means for transferring said granules by gravity from said cooling means to said
- storage container or containers. .Iaddend. .Iadd.34. The apparatus array of claim 33, wherein said mixing means comprise mechanical stirring means with lump-breaking cutters, said means for introducing a granulation agent comprises means for creating a vacuum or spraying system means supplied by a pump; and said mixer-granulator-dryer device includes means for regulating the temperature comprising a double jacket for circulating heat-exchange fluid, and vacuum means for creating vacuum. .Iaddend.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR82-21476 | 1982-12-21 | ||
FR8221476A FR2537872B1 (en) | 1982-12-21 | 1982-12-21 | PROCESS FOR THE MANUFACTURE OF EFFERVESCENT TABLETS |
FR83-19143 | 1983-11-30 | ||
FR838319143A FR2555439B1 (en) | 1983-11-30 | 1983-11-30 | PROCESS AND APPARATUS FOR MANUFACTURING GRANULES AND EFFERVESCENT TABLETS |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US06643980 Reissue | 1983-12-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
USRE33086E true USRE33086E (en) | 1989-10-10 |
Family
ID=26223202
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US06/643,980 Ceased US4614648A (en) | 1982-12-21 | 1983-12-20 | Process for manufacturing effervescent granules and tablets |
US07/071,991 Expired - Lifetime USRE33086E (en) | 1982-12-21 | 1987-07-10 | Process for manufacturing effervescent granules and tablets and high efficiency granulation tower for such process |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US06/643,980 Ceased US4614648A (en) | 1982-12-21 | 1983-12-20 | Process for manufacturing effervescent granules and tablets |
Country Status (19)
Country | Link |
---|---|
US (2) | US4614648A (en) |
EP (1) | EP0162043B1 (en) |
JP (1) | JPH07100653B2 (en) |
KR (1) | KR900007312B1 (en) |
AT (1) | AT394492B (en) |
CA (1) | CA1209040A (en) |
CH (1) | CH664491A5 (en) |
DE (1) | DE3390423C2 (en) |
DK (1) | DK163565C (en) |
EG (1) | EG17260A (en) |
ES (1) | ES528271A0 (en) |
GB (1) | GB2146244B (en) |
GR (1) | GR81352B (en) |
IT (1) | IT1175295B (en) |
MA (1) | MA19980A1 (en) |
NL (1) | NL193488C (en) |
PT (1) | PT77864B (en) |
SE (1) | SE457416B (en) |
WO (1) | WO1984002468A1 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5298261A (en) * | 1992-04-20 | 1994-03-29 | Oregon Freeze Dry, Inc. | Rapidly distintegrating tablet |
US5348745A (en) * | 1989-05-09 | 1994-09-20 | Miles Inc. | Aqueous granulation solution and a method of tablet granulation |
US5503846A (en) * | 1993-03-17 | 1996-04-02 | Cima Labs, Inc. | Base coated acid particles and effervescent formulation incorporating same |
US6620433B2 (en) | 2000-11-03 | 2003-09-16 | Laboratorios Belmac, S.A. | Dispersible and soluble galenic paracetamol formulation, method for its preparation and its applications |
US20090135666A1 (en) * | 2005-02-09 | 2009-05-28 | Satoru Watano | Kneading and granulating machine |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1209040A (en) * | 1982-12-21 | 1986-08-05 | Jean Bru | Manufacture of effervescent granules or tablets |
US4904478A (en) * | 1983-08-11 | 1990-02-27 | Mission Pharmacal Company | Slow-release sodium fluoride tablet and method for treatment of osteoporosis |
DE3440288A1 (en) * | 1984-11-05 | 1986-05-07 | Gergely, Gerhard, Dr.-Ing., Wien | PHARMACEUTICAL PREPARATION WITH A CONTENT OF AT LEAST ONE Mucous-irritating SUBSTANCE OR THE LIKE, PARTICULARLY PROFESSIONALS, AND METHOD FOR THE PRODUCTION THEREOF |
US4851221A (en) * | 1985-02-19 | 1989-07-25 | Mission Pharmacal Company | Liquid calcium supplementation from readily soluble mixtures of calcium compound and citric acid |
US4772467A (en) * | 1985-02-19 | 1988-09-20 | Board Of Regents, U T Systems | Osteoporosis inhibition by dietary calcium supplementation |
GB2174004B (en) * | 1985-04-23 | 1988-11-30 | American Cyanamid Co | Pharmaceutical tablet preparations |
IT1209667B (en) * | 1985-11-12 | 1989-08-30 | Zambon Spa | EFFEVERSCENT COMPOSITION ANALGESIC ADAPTITY. |
US4814177A (en) * | 1986-03-18 | 1989-03-21 | Board Of Regents, University Of Texas System | Ultradense and more soluble and bioavailable preparations of calcium citrate |
EP0275468B1 (en) * | 1986-12-20 | 1991-02-06 | Roche Diagnostics GmbH | Pharmaceutical compositions containing clodronate, and process for their preparation |
CA2009326C (en) * | 1989-05-09 | 1998-01-27 | Lawrence J. Daher | Aqueous granulation solution and a method of tablet granulation |
US5106534A (en) * | 1989-05-16 | 1992-04-21 | J. M. Huber Corporation | Endothermic blowing agents compositions and applications |
US5252618A (en) * | 1989-05-16 | 1993-10-12 | J. M. Huber Corporation | Endothermic blowing agents for strengthening weld lines in molded thermoplastic resins and products |
USRE35447E (en) * | 1989-05-16 | 1997-02-11 | J. M. Huber Corporation | Endothermic blowing agents for strengthening weld lines in molded thermoplastic resins and products |
US5250224A (en) * | 1989-05-16 | 1993-10-05 | J. M. Huber Corporation | Foamed products containing endothermic blowing agents and processes |
US5009809A (en) * | 1989-05-16 | 1991-04-23 | J. M. Huber Corporation | High temperature endothermic blowing agents compositions and applications |
US5009810A (en) * | 1989-05-16 | 1991-04-23 | J. M. Huber Corporation | Endothermic blowing agents compositions and applications |
US5302455A (en) * | 1989-05-16 | 1994-04-12 | J. M. Huber Corporation | Endothermic blowing agents compositions and applications |
USRE35368E (en) * | 1989-05-16 | 1996-10-29 | J. M. Huber Corporation | Endothermic blowing agents for surface migration of components in foamed products, compositions and applications |
US5317044A (en) * | 1989-05-16 | 1994-05-31 | J. M. Huber Corporation | Endothermic blowing agents for surface migration of components in foamed products, compositions and applications |
US5137655A (en) * | 1989-05-16 | 1992-08-11 | J. M. Huber Corporation | High temperature endothermic blowing agents compositions and applications |
US5252213A (en) * | 1989-06-20 | 1993-10-12 | University Of Washington | Dry dialysate composition |
US5234963A (en) * | 1992-05-13 | 1993-08-10 | Gaia Research | Production of encapsulated chemical foaming concentrates |
EP0673644A1 (en) * | 1994-03-18 | 1995-09-27 | E-PHARMA TRENTO S.p.A. | Process and plant for preparation of effervescent granules |
DE19734431A1 (en) * | 1997-08-08 | 1999-02-11 | Glatt Process Technology Gmbh | Method and device for working up a solution or solid suspension containing thermally labile components |
DE19931708A1 (en) * | 1999-07-08 | 2001-01-18 | Bayer Ag | Process for the preparation of rapidly disintegrating solid pharmaceutical preparations |
FR2796841B1 (en) * | 1999-07-28 | 2003-08-15 | Lipha | NEW PROCESS FOR THE PRODUCTION OF EFFERVESCENT MIXTURES AND THE TABLETS THEREOF |
JP5467751B2 (en) * | 2008-09-29 | 2014-04-09 | 小林製薬株式会社 | Amino acid-containing solid composition with suppressed protein coagulation action |
WO2013081567A1 (en) * | 2011-12-02 | 2013-06-06 | Mahmut Bilgic | Effervescent antipsychotic formulations |
WO2016042372A1 (en) | 2014-09-17 | 2016-03-24 | Steer Engineering Private Limited | Effervescent composition and method of making it |
WO2017098481A1 (en) | 2015-12-12 | 2017-06-15 | Steerlife India Private Limited | Effervescent compositions of metformin and processes for preparation thereof |
DE102016218135A1 (en) | 2016-09-21 | 2018-03-22 | Robert Bosch Gmbh | Production module for the production of solid dosage forms |
Citations (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2463962A (en) * | 1947-05-17 | 1949-03-08 | Fearn Lab Inc | Product for producing effervescing carbonated beverages |
US2497057A (en) * | 1950-02-07 | Toilet bowl -gleanee | ||
US2877159A (en) * | 1957-04-26 | 1959-03-10 | Ciba Pharm Prod Inc | Method for preparing tablet granulations |
DE1060093B (en) * | 1957-04-26 | 1959-06-25 | Ciba Geigy | New method for the production of tablet granules |
US2985562A (en) * | 1958-03-27 | 1961-05-23 | Warner Lambert Pharmaceutical | Effervescent compositions |
US2999293A (en) * | 1957-09-12 | 1961-09-12 | Warner Lambert Pharmaceutical | Process of granulating effervescent materials |
US3401216A (en) * | 1964-01-09 | 1968-09-10 | Bristol Myers Co | Methods for preparing pharmaceutical compositions |
US3480185A (en) * | 1966-06-20 | 1969-11-25 | Johnson & Johnson | Charged effervescing agent and medicament dispensing metering valve-actuated aerosol container producing a dose of medicament and carbonation in water |
FR2092893A1 (en) * | 1970-06-29 | 1972-01-28 | Bru Jean | |
US3773922A (en) * | 1971-04-06 | 1973-11-20 | Fr Dev Rech Sofrader | Method for the manufacture of effervescent tablets |
US3903255A (en) * | 1971-05-17 | 1975-09-02 | Rohm & Haas | Effervescent potassium chloride tablet |
US3946996A (en) * | 1972-04-18 | 1976-03-30 | Barmag Barmer Maschinenfabrik Aktiengesellschaft | Mixing and granulating apparatus |
US4093710A (en) * | 1976-07-07 | 1978-06-06 | Sandoz, Inc. | Rapid dissolving effervescent granules |
US4153678A (en) * | 1978-07-17 | 1979-05-08 | American Cyanamid Company | Levamisole effervescent tablets |
EP0011489A1 (en) * | 1978-11-16 | 1980-05-28 | Beecham Group Plc | An analgesic effervescent powder and process for its preparation |
US4267164A (en) * | 1980-01-31 | 1981-05-12 | Block Drug Company Inc. | Effervescent stannous fluoride tablet |
EP0076340A1 (en) * | 1981-10-06 | 1983-04-13 | Gerhard Dr. Gergely | Process for manufacturing effervescent granules which may be transformed, when required, into effervescent tablets |
AT372299B (en) * | 1980-12-15 | 1983-09-26 | Gergely Gerhard | DEVICE FOR PRODUCING THE DESIRED CASE FOR EQUIPMENT TO BE PROCESSED SHOWER GRANULES |
US4614648A (en) * | 1982-12-21 | 1986-09-30 | Jean Bru | Process for manufacturing effervescent granules and tablets |
Family Cites Families (3)
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---|---|---|---|---|
FR2154323A1 (en) * | 1971-09-29 | 1973-05-11 | Sofrader Sa | Effervescent tablets prdn - by controlled drying in effervescent granule formation |
FR2132521A1 (en) * | 1971-04-06 | 1972-11-24 | Sofrader Sa | Effervescent tablets prdn - by controlled drying in effervescent granule formation |
DE2842822C3 (en) * | 1978-09-30 | 1982-05-19 | Merz + Co GmbH & Co, 6000 Frankfurt | Medicinal preparations of poorly soluble medicinal substances in the form of effervescent granules |
-
1983
- 1983-12-19 CA CA000443701A patent/CA1209040A/en not_active Expired
- 1983-12-20 NL NL8320404A patent/NL193488C/en not_active IP Right Cessation
- 1983-12-20 EP EP84900064A patent/EP0162043B1/en not_active Expired
- 1983-12-20 AT AT0908083A patent/AT394492B/en not_active IP Right Cessation
- 1983-12-20 DE DE3390423T patent/DE3390423C2/en not_active Expired - Lifetime
- 1983-12-20 US US06/643,980 patent/US4614648A/en not_active Ceased
- 1983-12-20 CH CH4062/84A patent/CH664491A5/en not_active IP Right Cessation
- 1983-12-20 JP JP59500291A patent/JPH07100653B2/en not_active Expired - Lifetime
- 1983-12-20 WO PCT/FR1983/000253 patent/WO1984002468A1/en active IP Right Grant
- 1983-12-20 GR GR73291A patent/GR81352B/el unknown
- 1983-12-20 PT PT77864A patent/PT77864B/en unknown
- 1983-12-20 GB GB08427318A patent/GB2146244B/en not_active Expired
- 1983-12-21 KR KR1019830006082A patent/KR900007312B1/en not_active IP Right Cessation
- 1983-12-21 IT IT68331/83A patent/IT1175295B/en active
- 1983-12-21 EG EG79483A patent/EG17260A/en active
- 1983-12-21 MA MA20201A patent/MA19980A1/en unknown
- 1983-12-21 ES ES528271A patent/ES528271A0/en active Granted
-
1984
- 1984-08-20 SE SE8404142A patent/SE457416B/en not_active IP Right Cessation
- 1984-08-20 DK DK397984A patent/DK163565C/en not_active IP Right Cessation
-
1987
- 1987-07-10 US US07/071,991 patent/USRE33086E/en not_active Expired - Lifetime
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US2497057A (en) * | 1950-02-07 | Toilet bowl -gleanee | ||
US2463962A (en) * | 1947-05-17 | 1949-03-08 | Fearn Lab Inc | Product for producing effervescing carbonated beverages |
US2877159A (en) * | 1957-04-26 | 1959-03-10 | Ciba Pharm Prod Inc | Method for preparing tablet granulations |
DE1060093B (en) * | 1957-04-26 | 1959-06-25 | Ciba Geigy | New method for the production of tablet granules |
US2999293A (en) * | 1957-09-12 | 1961-09-12 | Warner Lambert Pharmaceutical | Process of granulating effervescent materials |
US2985562A (en) * | 1958-03-27 | 1961-05-23 | Warner Lambert Pharmaceutical | Effervescent compositions |
US3401216A (en) * | 1964-01-09 | 1968-09-10 | Bristol Myers Co | Methods for preparing pharmaceutical compositions |
US3480185A (en) * | 1966-06-20 | 1969-11-25 | Johnson & Johnson | Charged effervescing agent and medicament dispensing metering valve-actuated aerosol container producing a dose of medicament and carbonation in water |
FR2092893A1 (en) * | 1970-06-29 | 1972-01-28 | Bru Jean | |
US3773922A (en) * | 1971-04-06 | 1973-11-20 | Fr Dev Rech Sofrader | Method for the manufacture of effervescent tablets |
US3903255A (en) * | 1971-05-17 | 1975-09-02 | Rohm & Haas | Effervescent potassium chloride tablet |
US3946996A (en) * | 1972-04-18 | 1976-03-30 | Barmag Barmer Maschinenfabrik Aktiengesellschaft | Mixing and granulating apparatus |
US4093710A (en) * | 1976-07-07 | 1978-06-06 | Sandoz, Inc. | Rapid dissolving effervescent granules |
US4153678A (en) * | 1978-07-17 | 1979-05-08 | American Cyanamid Company | Levamisole effervescent tablets |
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US4267164A (en) * | 1980-01-31 | 1981-05-12 | Block Drug Company Inc. | Effervescent stannous fluoride tablet |
AT372299B (en) * | 1980-12-15 | 1983-09-26 | Gergely Gerhard | DEVICE FOR PRODUCING THE DESIRED CASE FOR EQUIPMENT TO BE PROCESSED SHOWER GRANULES |
EP0076340A1 (en) * | 1981-10-06 | 1983-04-13 | Gerhard Dr. Gergely | Process for manufacturing effervescent granules which may be transformed, when required, into effervescent tablets |
US4614648A (en) * | 1982-12-21 | 1986-09-30 | Jean Bru | Process for manufacturing effervescent granules and tablets |
Non-Patent Citations (4)
Title |
---|
Bartsch, "Die Pharmazeutische Industrie", vol. 41, pp. 696-698 (1979). |
Bartsch, Die Pharmazeutische Industrie , vol. 41, pp. 696 698 (1979). * |
Lieberman et al., "Pharmaceutical Dosage Forms: Tablets", vol. 3, pp. 34-37 (1982). |
Lieberman et al., Pharmaceutical Dosage Forms: Tablets , vol. 3, pp. 34 37 (1982). * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5348745A (en) * | 1989-05-09 | 1994-09-20 | Miles Inc. | Aqueous granulation solution and a method of tablet granulation |
US5298261A (en) * | 1992-04-20 | 1994-03-29 | Oregon Freeze Dry, Inc. | Rapidly distintegrating tablet |
US5503846A (en) * | 1993-03-17 | 1996-04-02 | Cima Labs, Inc. | Base coated acid particles and effervescent formulation incorporating same |
US6620433B2 (en) | 2000-11-03 | 2003-09-16 | Laboratorios Belmac, S.A. | Dispersible and soluble galenic paracetamol formulation, method for its preparation and its applications |
US20090135666A1 (en) * | 2005-02-09 | 2009-05-28 | Satoru Watano | Kneading and granulating machine |
US8721167B2 (en) * | 2005-02-09 | 2014-05-13 | Shinagawa Machinery Works Co., Ltd. | Kneading and granulating machine |
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