|Número de publicación||USRE36872 E|
|Tipo de publicación||Concesión|
|Número de solicitud||US 08/571,466|
|Fecha de publicación||12 Sep 2000|
|Fecha de presentación||13 Dic 1995|
|Fecha de prioridad||15 Ene 1992|
|Número de publicación||08571466, 571466, US RE36872 E, US RE36872E, US-E-RE36872, USRE36872 E, USRE36872E|
|Cesionario original||Laser Industries Ltd.|
|Exportar cita||BiBTeX, EndNote, RefMan|
|Citas de patentes (13), Otras citas (33), Citada por (25), Clasificaciones (10), Eventos legales (3)|
|Enlaces externos: USPTO, Cesión de USPTO, Espacenet|
This is a continuation of application Ser. No. 003,278, filed Jan. 12, 1993, now abandoned.
The present invention relates to a system for causing ablation of a target material of living tissue while not causing damage below a predetermined depth. The novel system is particularly useful using a carbon dioxide laser.
When using a laser for ablating tissue it is desirable to deliver maximum power density to the tissue to be ablated while minimizing temperature rise in adjacent tissue, particularly in the tissue underlying the tissue to be ablated preventing necrosis in such underlying tissue. Such a temperature rise in underlying tissue may cause thermal damage or carbonization, which generally results in increased scarring and healing time. For this purpose, surgical lasers used for tissue ablation are usually operated with short pulses to deliver high energy in short periods of time. Various pulsing techniques have been developed for this purpose, in which the energy applied for ablation is varied by changing the pulse repetition rate, pulse duration, and/or pulse energy.
Generally, it is desirable to provide power density of at least 40 watts/mm2 in order to obtain ablation. This power density must be provided, however, for a short enough period of time so the ablation is without carbonisation, and to minimize thermal damage below a depth of 50 micrometers. At the same time, it is desirable to have a spot diameter on the tissue of at least 3 mm to allow for controllable ablation, since a smaller diameter is more likely to produce holes rather than uniform tissue removal. In the pulse technique for operating a laser, however, these desirable characteristics oppose each other.
In this regard it is generally desirable to expose the tissue to pulses of less than 1 msec to minimize the depth of thermal damage, and to provide at least 0.1 sec between pulses to allow the tissue to cool down, while at the same time to provide an average power of not less than 20-30 watts to reduce the surgery time. However, in the pulse technique for operating a laser, these desirable characteristics also oppose each other.
Various prior art techniques are known is which a target material is scanned with laser radiation to selectively cause necrosis of the target material. Such prior art uses lasers that are absorbed nonuniformally by the target material so as to cause the selective necrosis. One such prior art teaching is U.S. Pat. No. 4,733,660 which issued to Irving Itzkan on Mar. 29, 1988 and is entitled Laser System for Proving Target Specific Energy Deposition and Damage.
A second such prior art teaching is in an article entitled Hexascan: A New Robotized Scanning Laser Handpiece by D. H. McDaniel et al, which appeared in Volume 45 of CUTIS page 300 in May of 1990.
An object of the present invention is to provide a novel laser system having advantages in the above respects when used for ablating a surface.
A system is provided for causing ablation of a target material of living tissue while not causing damage below a predetermined depth which includes a laser which generates a beam of laser radiation to be uniformly absorbed by the target material; a scanner for moving the beam of laser radiation in a predetermined pattern on the target material so that the "elements" of the target material are sequentially irradiated; and the rate at which the scanner moves the beam of laser radiation in the predetermined pattern is controlled so that ablation is caused uniformly on the target material but only to a predetermined depth.
In one embodiment of the system the scanning rate and predetermined pattern is such that each of the "elements" of the target material experiences a predetermined minimum time interval between applications of radiation thereto. In the preferred embodiment the predetermined minimum time interval is 0.1 seconds and the laser beam has an average power of at least 40 watts/mm2.
In the preferred embodiment of this invention the scanner causes the beam of laser radiation to trace Lissajous figures over said target material.
In a further embodiment of this invention wherein the scanned laser beam defines a solid cone with a circular base projected onto the surface of said target material wherein the circular base projected onto the target material has a radius of at least 1.5 mm and the laser beam is focused to a radius of no larger than 0.25 mm on the target material.
In the preferred embodiment of this invention the laser for generating the beam of laser radiation is a carbon dioxide laser.
The invention is herein described, by way of example only, with reference to the accompanying drawings, wherein:
FIG. 1 illustrates one form of laser system constructed in accordance with the present invention;
FIGS. 2-7 are diagrams helpful in explaining the Lissajous figures produced by the scanning system in the laser of FIG. 1;
FIG. 8 illustrates a hand-held laser apparatus constructed in accordance with the present invention for use in free-hand surgery; and
FIG. 9 illustrates another laser apparatus constructed in accordance with the present invention particularly useful for microsurgery.
FIG. 1 illustrates the main components of a laser system constructed in accordance with the present invention for use in ablating tissue, shown at T. Thus, the illustrated system includes a laser 2 which produces a continuous laser beam 4. In the preferred embodiment of this invention the laser 2 is a carbon dioxide laser. The continuous laser beam is applied to a laser scanner system, generally shown by box 6, which cyclically scans the beam along two orthogonal axes to cause the beam to trace Lissajous figures, shown generally at 8 in FIG. 1, over the tissue T to be ablated. The laser beam leaving the scanning system 6 first passes through a focussing lens 10 which focusses the laser beam on tissue T.
The scanning system 6 includes two mirrors 12, 14, each rotated by a motor M1. M2. These mirrors are so located with respect to the laser beam 4 and also to each other to cyclically scan the laser beam along two orthogonal axes, and to cause the beam to trace the Lissajous FIGS. 8 over the tissue T to be ablated.
The manner in which the Lissajous FIGS. 8 are produced by the scanning mirrors 12, 14 will now be described particularly with reference to FIGS. 2-7.
FIG. 2 illustrates a system including motor M1 rotating at angular velocity Ω1 about an axis defined by the normalised vector B1. A mirror (e.g., 12, FIG. 1) is fixed to the motor such that its normal, defined by N1, lies at an angle of θ/2 to the rotating axis B1. As the motor rotates, the vector N1 defines a cone of half angle θ/2. The axis of symmetry of the cone is defined by the vector B1. A ray, defined by vector A, impinging on the mirror at an angle of 45° to axis B1 will, according to the laws of reflection, produce reflected rays described by the time dependent vector C1(t). This vector C1(t) traces an envelope of a cone with an elliptical base. The vector Z1, which represents the axis of this cone, lies in the plane defined by vectors A and B1. The angle between vectors Z1 and B1 is also 45 degrees.
A Cartesian coordinate system based on the three vectors X1, Y1 and Z1 may now be defined. The origin of this coordinate system is represented by 01 in FIG. 2. The vector X1 lies in the plane containing vectors A, B1 and Z1, and is perpendicular to vector Z1. The direction of vector Y1 is perpendicular to vectors X1 and Z1.
The projections of the reflected rays can now be described by the following equations:
ax1 (t)=⊖ cos (Ω1 t+δ1) Eq. 1
ay1 (t)=⊖/√2 sin (Ω1 t+δ1)Eq. 2
ax1 (t) is the angle of the projection C1(t) in the plane X1-Z1;
ay1 (t) is the angle of the projection of C1(t) on the plane Y1-Z1;
and δ1 is an arbitrary phase which defines the angles a at time t=0.
The relatively large displacement associated with amplitude ⊖ in equation (1) lies in the plane containing vectors A and B1. The smaller amplitude ⊖/√2 of equation (2) is in the direction of vector Y1.
Now can be added a second motor M2 (FIG. 3), whose axis is defined by vector B2 rotating with angular velocity Ω2. A mirror (e.g., 14, FIG. 1) whose normal is N2(t) is fixed to motor M2 forming an angle of ⊖/2 between normal N2(t) and vector B2 (as in motor M1). Motor M2 will be aligned such that the axis of vector B2 lies at 45° to the axis of vector Z1. Vector B2 also lies in the plane defined by vectors Z1 and Y1. As a result, there is obtained reflected rays C2(t) which form a solid cone with a circular (not elliptical) base. The axis of symmetry Z2 of this cone lies at 45° to the axis B1 of the motor M1 and in the plane defined by vectors Z2 and B2.
A new Cartesian coordinate system may now be defined having an origin at 02 (see FIG. 3). Vector X2 is perpendicular to vector Z2 and lies in the plane defined by vectors B2 and Z2. Vector Y2 is perpendicular to vectors X2 and Z2.
The larger amplitude always exists in the X direction and the smaller amplitude in the Y direction. The two motors M1, M2 are aligned in such a way that the X direction of motor M1 combines with the Y direction of motor M2, and the Y direction of motor M1 combines with the -X direction of the second motor. In this way amplitude compensation is obtained, resulting in a cone with a circular (not elliptical) base.
All the rays C2(t) exiting from the second mirror (e.g., 14, in FIG. 1) are defined by the following equations: ##EQU1## Assuming δ1=-90° and δ2=0 then:
ax2 (t)=(⊖/√2) cos (Ω1·t)+⊖ cos(Ω2t) Eq. 5
Ay2 (t)=⊖ sin (Ω1·t)+(⊖/√2) sin (Ω2·t) Eq. 6
The angle of the exiting rays formed with axis Z2 can exist between zero and (⊖+⊖/√2). Thus the rays fill the whole area of the base of the cone whose half angle is defined by (⊖+⊖/√2).
A ray which is focussed by a lens of focal length "f" (e.g., lens 10, FIG. 1), will be displaced at the back focal plane of the lens by an amount a.f, where a is the angle subtended by the ray and the optical axis of the lens (see FIG. 4).
If a lens is placed perpendicular to axis Z2 (FIG. 5), a time dependent ray pattern will be produced at the focal plane of the lens (of focal length f), given by the following equations (see FIGS. 5 and 6):
x2 (t)=fax2(t) =f(⊖/√2) cos (Ω1 *t)+f⊖ cos (Ω2 *t) Eq. 7
y2 (t)=fay2(t) =f⊖ sin (Ω1 *t)+f(⊖/√2) sin (Ω2 *t) Eq. 8
For example, the lens may be of f=125 mm; the mirror wedge angle may be ⊖=2.34 mRad; and the angular velocities may be Ω1=600 rad/sec and Ω2=630 rad/sec. Let A=⊖f/√2=0.207; B=⊖f=0.293; and C=Ω2/Ω1=1.05. The ray exiting from the lens will scan at the focal plane an area whose limits are defined by a circle of radius 0.5 mm (see FIG. 6). Every 20 revolutions the ray completely scans the whole area and starts anew. The 20 revolution scan period is about 0.2 seconds. The resultant ray pattern can be seen in FIG. 6.
FIG. 8 illustrates the invention in one form of laser apparatus used for free-hand surgery. The laser apparatus illustrated in FIG. 8, therein designated 20, outputs a laser beam via an articulated-arm system 22 and a handpiece 24 grasped by the surgeon for directing the laser beam to the appropriate locations of the tissue T to be ablated in accordance with the present invention, the laser of FIG. 8 includes a scanner system, generally designate 26, as described above for cyclically scanning the continuous laser beam along two orthogonal axes and thereby to cause the beam to trace Lissajous figures over the tissue T to be ablated. In the apparatus illustrated in FIG. 8, the focussing lens (10, FIG. 1) is in the hand-held handpiece gripped and manipulated by the surgeon.
Following is one example of the parameters of a hand laser apparatus such as illustrated in FIG. 8.
1. Lens focal length 125 mm
2. Scan Radius r=2.0 mm (A=0.828 mm, B=1.172 mm)
3. Laser Power P=20 watts
4. Raw Beam Radius (before lens) W1=4 mm
5. Rotation speed of motors
6. Laser Wavelength =0.0106 mm
7. From FIG. 7 we see that
These two velocities, Vavg. and Vmin., are four times that shown in FIG. 7 because FIG. 7 represents a scan radius of 0.5 mm, whereas in the above example the radius is four times greater.
The above parameters produce the following results:
1. Spot radius at focus ##EQU2## 2. Power density at focus P.D.=P/S=P/π·wO2 =637 watts/mm' where S is the area of the focussed spot.
At this power density the thermal damage is minimal, and there are no signs of carbonisation. Assuming no scanning, the rate of evaporation Ve would be: ##EQU3##
At such a large speed there is no way of controlling the homegeneity of tissue removal. As a result, deep holes and valleys are formed.
If the scanner is operated at a scan radius of r=2 mm, the average power density on the tissue within the scanning area is:
P/π·r2 =20/π19 4=1.6 watts/mm2
The rate of evaporation of the scanned area is:
At this speed it is easy to control the rate of tissue removal causing minimal damage.
Because of the scan speed, each element of the tissue feels the equivalent of a short time pulse. The pulse duration is given by the ratio of the spot diameter at the focus (2WO) to the linear scan speed (Vs) (see FIG. 7).
The average pulse duration (Tavg.) is given by:
Pulses of this duration give very low thermal damage. The time between successive pulses is 0.2 sec. This is the ideal time for the tissue to cool down. This is a further reason for low thermal damage.
FIG. 9 illustrates the invention included in another form of laser apparatus particularly useful for microsurgery. The laser, generally designated 30 in FIG. 9, outputs a laser beam via a system of articulated arms 32 and a micro-manipulator 34, such as described in U.S. Pat. No. 4,228,341, to the tissue T to be ablated. Micro-manipulator 34 includes a joystick 35 enabling the surgeon to manipulate the laser beam as desired, and also an eyepiece and microscope (not shown) to permit the surgeon to view the working area containing the tissue to be ablated. The scanner system, generally designated 36, corresponds to the scanner system 6 in FIG. 1, and is effective to cyclically scan the continuous laser beam along two orthogonal axes as described above to cause the beam to trace Lissajous figures over the tissue to be ablated.
Following is one example of the parameters of a gynecological colposcope constructed as illustrated in FIG. 9 and having a working distance of 400 mm.
1. Focal length f=400 mm
2. Scan Radius r=2 mm
3. Laser Power 60 watts
4. Raw Beam radius w1=4 mm
5. Rotational speed of motors
6. Laser wavelength =0.0106 mm
7. From FIG. 8
The laser apparatus illustrated in FIG. 9 and constructed in accordance with the foregoing parameters produces the following results: ##EQU4## 2. Power Density at focus P.D.=P/S=P/πwO2 =165 watts/mm2. At this power density the thermal damage and carbonisation is minimal.
3. Assuming no scanning, the rate of evaporation would be:
This represents a speed too great for controlled work.
With the scanner, P.D.=P/πr2 =60/π22 =4.78 watts/mm2, and the rate of evaporation Ve=0.4×P.D.=0.4×4.78=1.9 mm.sec. This represents an evaporation rate which is very convenient for efficient working conditions.
4. Pulse duration Tavg=2Wo/Vavg=2×0.34/808=840 μsec.
Pulses of this duration create very low thermal damage.
While the invention has been described with respect to several preferred embodiments, it will be appreciated that these are set forth merely for purposes of example, and that many variations may be made. For example, the scanning need not trace Lissajous figures; in fact, only one scanning mirror is needed since the movement of the laser by the surgeon will cause the beam to scan the surface to be ablated. Also, more than two mirrors could be used. Many other variations, modifications and applications of the invention may be made.
|Patente citada||Fecha de presentación||Fecha de publicación||Solicitante||Título|
|US3884236 *||12 Nov 1973||20 May 1975||Krasnov Mikhail M||Method of glaucoma treatment|
|US4387952 *||27 Mar 1981||14 Jun 1983||Spectra-Physics, Inc.||Single axis beam scanner|
|US4469098 *||5 May 1981||4 Sep 1984||Davi Samantha K||Apparatus for and method of utilizing energy to excise pathological tissue|
|US4566453 *||8 Dic 1983||28 Ene 1986||Tohoku Ricoh Co., Ltd.||Vascular anastomosis apparatus|
|US4587396 *||22 Sep 1983||6 May 1986||Laser Industries Ltd.||Control apparatus particularly useful for controlling a laser|
|US4672969 *||6 Oct 1983||16 Jun 1987||Sonomo Corporation||Laser healing method|
|US4718418 *||8 Oct 1986||12 Ene 1988||Lri L.P.||Apparatus for ophthalmological surgery|
|US4733660 *||10 Dic 1986||29 Mar 1988||Medical Laser Research And Development Corporation||Laser system for providing target specific energy deposition and damage|
|US4917083 *||4 Mar 1988||17 Abr 1990||Heraeus Lasersonics, Inc.||Delivery arrangement for a laser medical system|
|US5071417 *||15 Jun 1990||10 Dic 1991||Rare Earth Medical Lasers, Inc.||Laser fusion of biological materials|
|US5280378 *||19 Oct 1990||18 Ene 1994||I.L. Med, Inc.||Cyclically scanned medical laser|
|US5411502 *||30 Dic 1993||2 May 1995||Laser Industries, Ltd.||System for causing ablation of irradiated material of living tissue while not causing damage below a predetermined depth|
|EP0172490A1 *||6 Ago 1985||26 Feb 1986||Medical Laser Research And Development Corporation||Laser system for providing target specific energy deposition and damage|
|1||"Aesthetic CO2 Laser System" literature, Aug. 1994, 2 pages.|
|2||*||Aesthetic CO 2 Laser System literature, Aug. 1994, 2 pages.|
|3||Andrew Blitzer, M.D., DDS, "Laser Photocoagulation in the Care of Patients with Osler-Weber-Rendu Disease" Operative Techniques in Otolaryngology--Head and Neck Surgery, vol. 5, No. 4, Dec. 1994, pp. 274-277.|
|4||*||Andrew Blitzer, M.D., DDS, Laser Photocoagulation in the Care of Patients with Osler Weber Rendu Disease Operative Techniques in Otolaryngology Head and Neck Surgery, vol. 5, No. 4, Dec. 1994, pp. 274 277.|
|5||Arielle N.B. Kauvar, et al. "Laser Therapy for Cutaneous Vascular Lesions", Operative Techniques in Otolaryngology--Head and Neck Surgery, vol. 5, No. 4, Dec. 1994, pp. 250-258.|
|6||*||Arielle N.B. Kauvar, et al. Laser Therapy for Cutaneous Vascular Lesions , Operative Techniques in Otolaryngology Head and Neck Surgery, vol. 5, No. 4, Dec. 1994, pp. 250 258.|
|7||*||Deposition Transcript (Min U Script) of Eliezer Zair, vol. 1, Oct. 15, 1996 Reliant Technologies Inc. v. Laser Industries Ltd., et ano (Sic.).|
|8||*||Deposition Transcript (Min U Script) of Eliezer Zair, vol. 2, Oct. 16, 1996 Reliant Technologies Inc. v. Laser Industries Ltd., et ano (Sic.).|
|9||*||Deposition Transcript (Min U Script) of Eliezer Zair, vol. 3, Oct. 17, 1996 Reliant Technologies Inc. v. Laser Industries Ltd., et ano (Sic.).|
|10||*||Deposition Transcript (Min U Script) of Eliezer Zair, vol. 4, Oct. 18, 1996 Reliant Technologies Inc. v. Laser Industries Ltd., et ano (Sic.).|
|11||Deposition Transcript (Min-U-Script) of Eliezer Zair, vol. 1, Oct. 15, 1996 Reliant Technologies Inc. v. Laser Industries Ltd., et ano (Sic.).|
|12||Deposition Transcript (Min-U-Script) of Eliezer Zair, vol. 2, Oct. 16, 1996 Reliant Technologies Inc. v. Laser Industries Ltd., et ano (Sic.).|
|13||Deposition Transcript (Min-U-Script) of Eliezer Zair, vol. 3, Oct. 17, 1996 Reliant Technologies Inc. v. Laser Industries Ltd., et ano (Sic.).|
|14||Deposition Transcript (Min-U-Script) of Eliezer Zair, vol. 4, Oct. 18, 1996 Reliant Technologies Inc. v. Laser Industries Ltd., et ano (Sic.).|
|15||*||Deposition Transcript of Joshua Raif, vol. I, Oct. 22, 1996, Laser Industries Ltd., et al. v. Reliant Technologies Inc.|
|16||*||Deposition Transcript of Joshua Raif, vol. II, Oct. 23, 1996, Laser Industries Ltd., et al. v. Reliant Technologies Inc.|
|17||*||Deposition Transcript of Joshua Raif, vol. III, Oct. 24, 1996, Laser Industries Ltd., et al. v. Reliant Technologies Inc.|
|18||*||Deposition Transcript of Joshua Raif, vol. IV, Oct. 25, 1996, Laser Industries Ltd., et al. v. Reliant Technologies Inc.|
|19||*||Judge Claudia Wilken s Order Denying Reliant s Motion For Partial Summary Judgment and Granting Laser s Counter Motion (Feb. 21, 1997).|
|20||Judge Claudia Wilken's Order Denying Reliant's Motion For Partial Summary Judgment and Granting Laser's Counter Motion (Feb. 21, 1997).|
|21||Michael Slatkine, et al., "Instrumentation For Office Laser Surgery", Operative Techniques in Otolaryngology--Head and Neck Surgery, vol. 5, No. 4, Dec. 1994, pp. 211-217.|
|22||*||Michael Slatkine, et al., Instrumentation For Office Laser Surgery , Operative Techniques in Otolaryngology Head and Neck Surgery, vol. 5, No. 4, Dec. 1994, pp. 211 217.|
|23||*||Microprocessor controlled scanning microprocessor for carbon dioxide laser surgery, J. Neurosurgery 59, Dec. 1983, pp. 1098 1099.|
|24||Microprocessor-controlled scanning microprocessor for carbon-dioxide laser surgery, J. Neurosurgery 59, Dec. 1983, pp. 1098-1099.|
|25||R. Rox Anderson, et al., "Selective Photothermolysis: Precise Microsurgery by Selective Absorption of Pulsed Radiation", Science, vol. 220, Apr. 29, 1993, pp. 524-527.|
|26||*||R. Rox Anderson, et al., Selective Photothermolysis: Precise Microsurgery by Selective Absorption of Pulsed Radiation , Science, vol. 220, Apr. 29, 1993, pp. 524 527.|
|27||*||Sharplan 771 Microscan, Mar. 28, 1985.|
|28||*||Sharplan 771B Microscan, Laser Industries (1985).|
|29||*||Sharplan Lasers, Inc. Outgoing Fax from Karen Amburgey, Oct. 19, 1994.|
|30||*||Sharplan Swiftlase Flashscan, Jun., 1993.|
|31||Sharplan Swiftlase.sup.™ Flashscan, Jun., 1993.|
|32||*||The Computerized Laser Scanner. Sharplan 775 Laser Industries.|
|33||The Computerized Laser Scanner. Sharplan.sup.™ 775 Laser Industries.|
|Patente citante||Fecha de presentación||Fecha de publicación||Solicitante||Título|
|US6575964||4 Feb 2000||10 Jun 2003||Sciton, Inc.||Selective aperture for laser delivery system for providing incision, tissue ablation and coagulation|
|US6743221||12 Mar 2002||1 Jun 2004||James L. Hobart||Laser system and method for treatment of biological tissues|
|US6770069||21 Jun 2002||3 Ago 2004||Sciton, Inc.||Laser applicator|
|US7090670||31 Dic 2003||15 Ago 2006||Reliant Technologies, Inc.||Multi-spot laser surgical apparatus and method|
|US7184184||31 Dic 2003||27 Feb 2007||Reliant Technologies, Inc.||High speed, high efficiency optical pattern generator using rotating optical elements|
|US7196831||9 Ago 2004||27 Mar 2007||Reliant Technologies, Inc.||Two-dimensional optical scan system using a counter-rotating disk scanner|
|US7282060||21 Dic 2004||16 Oct 2007||Reliant Technologies, Inc.||Method and apparatus for monitoring and controlling laser-induced tissue treatment|
|US7372606||20 Jun 2005||13 May 2008||Reliant Technologies, Inc.||Optical pattern generator using a single rotating component|
|US7411711||26 Feb 2007||12 Ago 2008||Reliant Technologies, Inc.||High speed, high efficiency optical pattern generator using rotating optical elements|
|US7413572||14 Jun 2004||19 Ago 2008||Reliant Technologies, Inc.||Adaptive control of optical pulses for laser medicine|
|US7480086||4 Sep 2007||20 Ene 2009||Reliant Technologies, Inc.||High speed, high efficiency optical pattern generator using rotating optical elements|
|US7636186||31 Oct 2007||22 Dic 2009||Reliant Technologies, Inc.||High speed, high efficiency optical pattern generator using rotating optical elements|
|US8291913||18 Ago 2008||23 Oct 2012||Reliant Technologies, Inc.||Adaptive control of optical pulses for laser medicine|
|US9351792||19 Jul 2007||31 May 2016||The General Hospital Corporation||Method and apparatus for dermatological treatment and fractional skin resurfacing|
|US20030109787 *||12 Dic 2001||12 Jun 2003||Michael Black||Multiple laser diagnostics|
|US20030109860 *||12 Dic 2001||12 Jun 2003||Michael Black||Multiple laser treatment|
|US20030216719 *||14 Feb 2003||20 Nov 2003||Len Debenedictis||Method and apparatus for treating skin using patterns of optical energy|
|US20050141068 *||31 Dic 2003||30 Jun 2005||Debenedictis Leonard C.||High speed, high efficiency optical pattern generator using rotating optical elements|
|US20050143719 *||31 Dic 2003||30 Jun 2005||Sink Robert K.||Multi-spot laser surgical apparatus and method|
|US20050259306 *||9 Ago 2004||24 Nov 2005||Broome Barry G||Two-dimensional optical scan system using a counter-rotating disk scanner|
|US20080208179 *||26 Oct 2007||28 Ago 2008||Reliant Technologies, Inc.||Methods of increasing skin permeability by treatment with electromagnetic radiation|
|US20140330260 *||7 Ago 2012||6 Nov 2014||Carl Zeiss Meditec Ag||Sectioning a transparent material using optical radiation|
|USRE42594||13 Oct 2005||2 Ago 2011||Reliant Technologies, Inc.||Tissue cooling rod for laser surgery|
|USRE43881||21 Jun 2011||25 Dic 2012||Reliant Technologies, Inc.||Tissue cooling rod for laser surgery|
|USRE46208||21 Jun 2011||22 Nov 2016||Reliant Technologies, Llc||Method for cryogenically treating tissue below the skin surface|
|Clasificación de EE.UU.||606/10, 606/11|
|Clasificación internacional||B23K26/08, B23K26/073|
|Clasificación cooperativa||B23K26/073, B23K26/08, B23K26/0884|
|Clasificación europea||B23K26/073, B23K26/08L2B, B23K26/08|
|26 Abr 2004||PRDP||Patent reinstated due to the acceptance of a late maintenance fee|
Effective date: 20000912
|15 Nov 2006||REMI||Maintenance fee reminder mailed|
|27 Abr 2007||LAPS||Lapse for failure to pay maintenance fees|