|Número de publicación||USRE37704 E1|
|Tipo de publicación||Concesión|
|Número de solicitud||US 09/534,842|
|Fecha de publicación||14 May 2002|
|Fecha de presentación||28 Mar 2000|
|Fecha de prioridad||22 Mar 1990|
|Número de publicación||09534842, 534842, US RE37704 E1, US RE37704E1, US-E1-RE37704, USRE37704 E1, USRE37704E1|
|Cesionario original||Argomed Ltd.|
|Exportar cita||BiBTeX, EndNote, RefMan|
|Citas de patentes (173), Otras citas (3), Citada por (13), Clasificaciones (35), Eventos legales (7)|
|Enlaces externos: USPTO, Cesión de USPTO, Espacenet|
This application is for a continuation-in-part of my prior patent application Ser. No. 07/669,366, filed Mar. 14, 1991 now U.S. Pat. No. 5,257,977.
The present invention relates to thermal treatment apparatus for thermally treating selected tissues of a subject. The invention is particularly useful as a thermal treatment apparatus for treating prostate, bladder and uterus, and is described below particularly with respect to an apparatus for treating the prostate. The invention also relates to a catheter construction, a heater, a peristaltic pump, and a thermal sensor assembly, all especially useful in the novel thermal treatment apparatus.
Thermal treatment is now a recognized form of treatment of certain types of ailments including benign prostatic hyperplasia (BPH), prostatitis, and prostate cancer. My prior U.S. application Ser. No. 07/669,366, filed Mar. 14, 1991, now U.S. Pat. No. 5,257,977 discloses one form of thermal treatment apparatus including a catheter insertable into the subject's urethra. The proximal end of the catheter includes an inflatable anchoring section in the form of a balloon to be anchored in the subjects bladder, and a heating section which, when the balloon is so anchored, extends through the subject's prostate. A heated liquid, such as water, is used to inflate the balloon and is also circulated through the heating section to heat the adjacent tissues of the prostate and the bladder neck.
The present invention relates to this type of thermal treatment apparatus but provides a number of important advantages, as will be described more particularly below.
According to the present invention, there is provided a thermal treatment apparatus for thermally treating selected tissues of a subject located in or near a body cavity, comprising a catheter insertable into the subject's body cavity and including a proximal end formed with an inflatable anchoring section for anchoring the catheter in the body cavity, a distal end to be located externally of the body cavity, and an inflatable heating section adjacent the proximal end to be located near the tissue to be heated. The catheter is formed with first and second passageways extending from the distal end to the, inflatable heating section for circulating heated fluid through the inflatable heating section but not through the inflatable anchoring section; and a third passageway from the distal end to the inflatable anchoring section for inflating the inflatable anchoring section with a non-heated fluid, whereby the inflatable heating section and the tissue in its proximity may be heated to a desired high temperature without correspondingly heating the inflatable anchoring section and the tissue in its proximity.
By thus inflating the anchoring section at the proximal end of the catheter with a separate, non-heated fluid, the heating fluid may be more particularly targeted, by the inflatable heating section, to the tissue to be subjected to the thermal treatment, thereby enabling higher temperatures to be applied if desired.
According to a another aspect of the invention, there is provided a thermal treatment apparatus for thermally treating selected tissues of a subject located in or near a body cavity, comprising: a catheter insertable into the subject's body cavity and including a proximal end having an inflatable anchoring section for anchoring the catheter in the body cavity, a distal end to be located externally of the body cavity, and an inflatable heating section adjacent the proximal end to be located near the tissue to be heated; first and second passageways from the distal end to the inflatable heating section for circulating heated fluid through the inflatable heating section but not through the inflatable anchoring section; a first thermal sensor assembly near the inlet end of the first passageway for measuring the temperature of the heated fluid entering the first passageway; and a second thermal sensor assembly near the outlet end of the second passageway for measuring the temperature of the heated liquid exiting from the second passageway.
More particularly, each of the two thermal sensor assemblies includes: a thermal sensor, a metal tube connectable to the respective end of the respective passageway of the catheter to receive the heated fluid flowing therethrough; a metal thermal coupling member formed with a recess on one face for receiving the thermal sensor therein, a recess on the opposite face complementary to the shape of the metal tube for receiving the metal tube therein, and a relatively thin web between the two recesses; and a cover pressing the metal tube to the metal thermal coupling member.
According to a still further aspect of the invention, there is provided a liquid heater which is particularly useful in such thermal treatment apparatus and including a heating block formed with a semi-spherical cavity; a container defining a liquid reservoir and also formed with a semispherical wall removably receivable in the cavity of the heating block; a cover attached to the container; a liquid inlet tube passing through the cover for inletting a liquid into the container to be heated by the heating block; and a liquid outlet tube passing through the cover for outletting a liquid from the container after having been heated by the heating block.
According to a further aspect of the invention, there is provided a peristaltic pump particularly useful in thermal treatment apparatus, which peristaltic pump includes a housing formed with a cylindrical cavity; and a rotor rotatably mounted within the cavity and carrying rollers engageable with a peristaltic tube insertable into the cavity for pressing the peristaltic tube against a wall of the housing in order to pump a liquid through the peristaltic tube during the rotation of the rotor; the wall of the housing including a skirt depending from a lid removably received over the cylindrical cavity; the depending skirt extending less than the circumference of the lid to produce an interruption in the housing wall against which the peristaltic tube is pressed by the rollers of the rotor.
Further features and advantages of the invention will be apparent from the description below.
The invention is herein described, by way of example only, with reference to the accompanying drawings, wherein:
FIG. 1 is a block diagram illustrating the main components of a thermal treatment apparatus constructed in accordance with the present invention;
FIG. 2 is a view, partially in longitudinal section diagrammatically illustrating one form of catheter constructed in accordance with the present invention for use in the thermal treatment apparatus of FIG. 1;
FIG. 3 is a view, partially in longitudinal section and rotated 90° with respect to FIG. 2, illustrating the catheter of FIG. 2;
FIGS. 4, 5 and 6 are transverse sectional views along lines IV—IV, V—V and VI—VI in FIG. 3;
FIG. 7 is a bottom view illustrating one form of liquid heater constructed in accordance with the invention for use in the thermal treatment apparatus of FIG. 1;
FIG. 7a is a sectional view along line VIIa—VIIa of FIG. 7;
FIG. 8 is a longitudinal sectional view along line VIII—VIII of FIG. 9, and FIG. 9 is a transverse sectional view along line IX—IX of FIG. 8, of one form of peristaltic pump constructed in accordance with the invention, FIG. 9a being a fragmentary detail view along line IXa—IXa of FIG. 9;
FIG. 10 is a transverse sectional view along line X—X of FIG. 11, and FIG. 11 is a longitudinal sectional view along line XI—XI of FIG. 10, illustrating one form of thermal sensor assembly constructed in accordance with the invention for use in the thermal treatment apparatus of FIG. 1.
The thermal treatment apparatus diagrammatically illustrated in FIG. I includes a catheter 2 insertable into a subject's body cavity to be treated thermally. In the example to be described below, the heat is applied to treat the prostate. The catheter 2 would therefore be inserted into the subject's urethra, such that one end of the catheter is anchored in the subject's bladder. This locates a heating section of the catheter in the subject's prostate.
The thermal treatment apparatus illustrated in FIG. 1 further includes a heater 4 for heating a fluid, in this case a liquid such as water, to be circulated in a closed circuit through the heating section of the catheter by means of a pump 6, The temperature of the heating liquid inletted from pump 6 into the catheter 2 is measured by a thermal sensor assembly 8, and the temperature of the liquid exiting from the catheter 2 to the heater 4 is measured by another thermal sensor assembly 10. The illustrated apparatus further includes a controller 12 which controls both the heater 4 and the pump 6 in response to the temperature sensed by sensor assemblies 8 and 10 and another sensor (to be described below) in the heater 4.
The construction of the catheter 2 is shown in FIGS. 2-6; the construction of the liquid heater 4 is shown in FIGS. 7 and 7a; the construction of the pump 6 is shown in FIGS. 8, 9 and 9 a; and the construction of the two thermal sensor assemblies 8 and 10 is shown in FIGS. 10 and 11.
The catheter 2, as shown in FIGS. 2-6, includes a long slender tube 20 formed with an inflatable anchoring section 21 at the proximal end for anchoring the catheter in the subject's bladder, and thereby for locating an inflatable cylindrical heating section 22 extending through the subject's prostate when the catheter is so anchored. The opposite end of the catheter, called the distal end, is to be located externally of the subject's urethra so as to be readily accessible for inflating the proximal anchoring section 21 and for inflating and circulating a heating liquid through the inflatable heating section 22.
The heating liquid is circulated through the inflatable heating section 22 via two passageways 24 a, 24 b having an inlet 25 and an outlet 26 at the distal end 23 of the catheter. The inflatable anchoring section 21 of the catheter is inflated by an unheated fluid, such as air, introduced via an inlet 27 at the distal end 23 and communicating with the anchoring section 21 via the third passageway 28 and an opening 29.
The portion of the catheter from the distal end 23 to the inflatable heating section 22 is thermally insulated from the subject's tissue by means of outer chambers 30, 30 a and 30 b enclosing passageways 24 a, 24 b, referred to generically by numeral 24, through which the heating liquid is circulated to the heating section 22. One of these chambers communicates with passageway 28 through which unheated air is applied to inflate the anchoring section 21.
The catheter also includes an extension 31 at the proximal end, which extension is received within the subject's bladder. Extension 31 is formed with an opening 32 for draining the subject's bladder via a passageway 33 passing through the length of the catheter and terminating in an outlet 34 at the distal end 23 of the catheter for connection to a drain. Extension 31 and its passageway 33 may also be used for introducing a drug into the bladder if desired.
The Heater 4 (FIG. 7)
The liquid heater 4, as more particularly illustrated in FIG. 7, includes a heating block 40 made of a good heat-conducting material, such as aluminum. Heating block 40 is of dome shape to define a smoothly curved semi-spherical cavity 41, and is integrally formed with four perpendicular ribs 42. A plurality of electrical heating elements 43, and one or more thermal sensors 44, are encased within the heating block 40. As seen in FIG. 7, an electrical heating element 43 is encased in each of the four ribs 42, and thermal sensor 44 is encased in each of the two opposite sides of the heating block, midway between two heating elements 43. The dome-shaped section of the heating block is relatively thin, as shown at 45 in FIG. 7a, to thereby reduce its thermal mass.
The heating block 40 illustrated in FIG. 7a further includes a removable container 50 serving as a water reservoir and formed with a complementary-curved wall 51, i.e., of semi-spherical configuration corresponding to the semi-spherical configuration of cavity 41. The semi-spherical wall 51 of container 50, however, is of slightly smaller dimensions than the heating block cavity 41 so as to provide a small gap 52 adapted to receive a small quantity of a liquid 53 to provide a good thermal coupling between block 40 and container wall 51. The semi-spherical shape of the container wall 51 permits it to be of a thin- wall construction and therefore sufficiently inexpensive so as to be disposable after one-time use. The thinness of the plastic wall also provides good thermal conductivity between heating block 40 and the interior of container 50.
Container 50 further includes a cover 54, preferably bonded by an adhesive or solvent or welded to the curved wall 51 of the container. Cover 54 is formed with a reentry tube 55 substantially centrally of the cover for receiving an inlet tube 56 which inlets into the container the liquid to be heated by the heating block 40. A second reentry tube 57 is formed in cover 54 laterally Of reentry tube 55, for receiving the outlet tube 58 which outlets the liquid from the container. The inlet reentry tube 55 extends from cover 54 substantially to the bottom of the container 50, whereas the outlet reentry tube 57 terminates close to the top of the container 50. This arrangement provides a relatively large residence time and contact surface for heating the liquid as it is circulated within container 50 from the inlet 56 to the outlet 58.
The Peristaltic Pump 6 (FIGS. 8, 9 and 9 a)
Pump 6 in FIG. 1 is a peristaltic pump as more particularly illustrated in FIGS. 8, 9 and 9 a. It includes a housing 60 formed with a cylindrical cavity 61. Disposed within cylindrical cavity 61 is a rotor 62 connected by a drive shaft 63 to a gear motor (not shown) and including a pair of spaced discs 64 a, 64 b rotatably mounting between them a plurality (3) of rollers 65 within cavity 61. Also located within the cylindrical cavity 61 is a peristaltic tube 66 which is engageable by the roller 65 for pumping the liquid through the tube during the rotation of rotor 62. Assuming rotor 62 is rotated counter-clockwise in FIG. 9, the liquid will be pumped through the peristaltic tube 66 from an inlet nipple 67 to an outlet nipple 68.
As shown in FIG. 8, housing 60 further includes a lid 70 formed with a large central opening 71 for accommodating disc 64 of the rotor 62. Lid 70 is formed with a depending skirt 72 which extends into the cylindrical cavity 61 such that the peristaltic tube 66 is located between the inner surface of skirt 72 and the rollers 65. Skirt 72 extends only for a part of the circumference of the lid, e.g., from 160° to 200°, to accommodate the inlet and outlet ends of the peristaltic tube 66. As shown in FIG. 9, skirt 72 extends slightly more than 180°; also, its leading edge 73 and its trailing edge 74 are tapered to provide a gradual application of the pressure to the peristaltic tube by the roller 65, and a gradual release of the pressure.
Housing 60 is of polygonal, preferably square, cross-section to provide a flat surface 60 a. Lid 70 is provided with a depending pin 75 in contact with the outer flat surface 60 a of housing 60 (see FIGS. 9 and 9a) to prevent rotation of the lid during the rotation of the rotor 62.
The illustrated construction, including the depending skirt 72, facilitates the assembly of the peristaltic pump with the peristaltic tube 66 between the skirt and the rollers 65. Thus, with the lid removed the peristaltic tube 66 may be conveniently applied around the rollers 65. The lid 70 may then be applied with its skirt 72 received between the peristaltic tube 66 and the inner surface of the cylindrical cavity 61 formed in housing 60, so as to squeeze the tube between it and the rollers 65. For this purpose, the lower edge of skirt 72 is tapered, as shown at 76 in FIGS. 8 and 9a, to facilitate the application of the skirt.
The foregoing construction not only facilitates the assembly of the peristaltic pump, but also covers the rollers 65 to minimize exposure to a person's fingers or the like. In addition, the thickness of skirt 72 influences the outlet pressure produced by the pump, so that lids 70 with different thickness skirts 72 may be provided to provide different outlet pressures. In addition, the inner surface of the skirt 72 may be provided with one or more grooves, as shown at 77 in FIG. 9, to produce a pulsatile output.
The thermal sensors assemblies 8, 10
The thermal sensor assemblies 8, 10 are more particularly illustrated in FIGS. 10 and 11. They are both enclosed within a common housing 80 in the shape of an “H” and closed by a common cover 31. Thermal sensor assembly 8 near the inlet end of the catheter 2 includes a thermal sensor element 82 received within a rectangular recess formed in a metal thermal coupling member 83. The opposite face of the coupling member is formed with a recess for receiving a metal tube 84 connectable to an inlet tube 85 near the inlet end of the catheter. Thermal sensor assembly 10 similarly includes a thermr al sensor element 86 received within a recess formed in another thermal coupling member 87. The opposite face of member 87 is similarly formed with a recess for receiving a metal tube 88 adapted to be coupled to an outlet tube 89 near the outlet end of the catheter. Electrical connections are made to the two thermal sensor elements 82 and 86 via a cable 90 leading to the controller 12 in FIG. 1.
The two thermal coupling members 83, 87, as well as the two tubes 84, 88, are of a metal, such as stainless steel, having relatively good thermal conductivity. The coupling members 83, 87 include relatively thin web portions 83 a, 87 a, respectively, between the thermal sensor elements 82, 86 and the metal tubes 84, 88, so as to provide a good thermal coupling between the liquid flowing through the two metal tubes and their respective thermal sensor elements. The cover 81, fixed to the common H-shaped housing 80 in any suitable manner, presses the metal tubes 94, 88 firmly against their respective metal coupling members 83, 87.
The overall operation of the thermal treatment apparatus illustrated in the drawings is as follows:
The catheter 2 is inserted into the urethra of the subject until the inflatable anchoring section 21 at the proximal end passes through the subject's bladder neck. An unheated fluid, preferably air, is introduced via inlet 27 and passageway 28 into the interior of the anchoring section 21 to inflate it. This anchors section 21 in the subject's bladder, wherepon the cylindrical heating section 22 of the catheter extends through the subject's prostate.
A heating fluid, such as water, is then pumped from the container 50 via pump 6 into the inlet 25 of passageway 24 a, to fill the catheter and to inflate the cylindrical heating section 22 of the catheter. Additional water is added to the catheter (e.g., via a separate inlet in the connector connecting the catheter to the closed circuit) to completely fill the closed circuit including container 50 and the catheter 2. The water heated within container 50 is circulated by the peristaltic pump 6 through the closed circuit including the cylindrical heating section 22 of the catheter.
During the circulation of the heating liquid, the sensor assemblies 8, 10 sense the temperature of the heating liquid near the inlet and outlet ends of the catheter, respectively. These sensor assemblies, together with the thermal sensors 44 in the electrical heater 4, control the controller 12 to maintain the desired temperature. Only the inflated heating section 22 of the catheter is effective to heat tissue, because of the thermal insulation provided by the unheated air within the anchoring section 21 of the catheter, and within chambers 30 of the remaining portion of the catheter. Accordingly, the liquid applied to the inflatable heating section 22 may be heated to a relatively high temperature for application to the tissue within the prostate, with less danger of unduly heating other tissue contacted by the catheter. The inflation of the heating section 22 of the catheter also presses that section firmly against the tissue to be thermally treated thereby further enhancing the heating effects.
Drain opening 32 at the proximal end of the catheter, and passageway 33 through the catheter, provide a drain for the bladder liquids or enable the introduction of a drug into the bladder.
While the invention has been described with respect to one preferred embodiment, it will be appreciated that many other variations, modifications and applications of the invention may be made.
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|1||Abstract, Kaver et al., "A New Transurethral Water-Induced Thermal (WIR) Dilation Device for the Treatment of BPH," presented at SIU, Sydney, Australia, Poster Session 26, BPH, Thermotherapy and Hypothermia (Sep. 1994).|
|2||European Search Report, Application No. EP 95 10 3189 dated Sep. 26, 1995.|
|3||European Search Report, Application No. EP 97 10 6282 dated Dec. 7, 1999.|
|Patente citante||Fecha de presentación||Fecha de publicación||Solicitante||Título|
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|Clasificación de EE.UU.||604/113, 604/97.01, 606/28, 604/153|
|Clasificación internacional||A61F2/958, A61B17/00, F04B43/12, A61F7/00, A61B17/22, A61F7/12, A61F7/02, A61B18/00, A61B18/08, F24H1/12|
|Clasificación cooperativa||A61B2018/00101, A61F2007/025, A61F2007/0095, A61F2007/0054, F04B43/1253, A61B18/08, A61M25/10, A61F7/12, A61B2018/00547, A61F7/123, A61B2018/00166, A61F2007/0086, A61B2017/00274, F24H1/121, A61B2017/22038|
|Clasificación europea||A61B18/08, F24H1/12B, A61M25/10, F04B43/12G, A61F7/12, A61F7/12B|
|10 Dic 2002||AS||Assignment|
|24 Feb 2003||AS||Assignment|
|29 Dic 2003||AS||Assignment|
|21 Ene 2004||FPAY||Fee payment|
Year of fee payment: 8
|27 Jul 2005||AS||Assignment|
Owner name: WIT IP CORPORATION, MASSACHUSETTS
Free format text: RELASE OF SECURITY AGREEMENT;ASSIGNOR:ANTARES CAPITAL CORPORATION;REEL/FRAME:016309/0595
Effective date: 20050721
|3 Mar 2008||REMI||Maintenance fee reminder mailed|
|22 Ago 2008||LAPS||Lapse for failure to pay maintenance fees|