|Número de publicación||USRE37704 E1|
|Tipo de publicación||Concesión|
|Número de solicitud||US 09/534,842|
|Fecha de publicación||14 May 2002|
|Fecha de presentación||28 Mar 2000|
|Fecha de prioridad||22 Mar 1990|
|Número de publicación||09534842, 534842, US RE37704 E1, US RE37704E1, US-E1-RE37704, USRE37704 E1, USRE37704E1|
|Cesionario original||Argomed Ltd.|
|Exportar cita||BiBTeX, EndNote, RefMan|
|Citas de patentes (173), Otras citas (3), Citada por (17), Clasificaciones (35), Eventos legales (7)|
|Enlaces externos: USPTO, Cesión de USPTO, Espacenet|
This application is for a continuation-in-part of my prior patent application Ser. No. 07/669,366, filed Mar. 14, 1991 now U.S. Pat. No. 5,257,977.
The present invention relates to thermal treatment apparatus for thermally treating selected tissues of a subject. The invention is particularly useful as a thermal treatment apparatus for treating prostate, bladder and uterus, and is described below particularly with respect to an apparatus for treating the prostate. The invention also relates to a catheter construction, a heater, a peristaltic pump, and a thermal sensor assembly, all especially useful in the novel thermal treatment apparatus.
Thermal treatment is now a recognized form of treatment of certain types of ailments including benign prostatic hyperplasia (BPH), prostatitis, and prostate cancer. My prior U.S. application Ser. No. 07/669,366, filed Mar. 14, 1991, now U.S. Pat. No. 5,257,977 discloses one form of thermal treatment apparatus including a catheter insertable into the subject's urethra. The proximal end of the catheter includes an inflatable anchoring section in the form of a balloon to be anchored in the subjects bladder, and a heating section which, when the balloon is so anchored, extends through the subject's prostate. A heated liquid, such as water, is used to inflate the balloon and is also circulated through the heating section to heat the adjacent tissues of the prostate and the bladder neck.
The present invention relates to this type of thermal treatment apparatus but provides a number of important advantages, as will be described more particularly below.
According to the present invention, there is provided a thermal treatment apparatus for thermally treating selected tissues of a subject located in or near a body cavity, comprising a catheter insertable into the subject's body cavity and including a proximal end formed with an inflatable anchoring section for anchoring the catheter in the body cavity, a distal end to be located externally of the body cavity, and an inflatable heating section adjacent the proximal end to be located near the tissue to be heated. The catheter is formed with first and second passageways extending from the distal end to the, inflatable heating section for circulating heated fluid through the inflatable heating section but not through the inflatable anchoring section; and a third passageway from the distal end to the inflatable anchoring section for inflating the inflatable anchoring section with a non-heated fluid, whereby the inflatable heating section and the tissue in its proximity may be heated to a desired high temperature without correspondingly heating the inflatable anchoring section and the tissue in its proximity.
By thus inflating the anchoring section at the proximal end of the catheter with a separate, non-heated fluid, the heating fluid may be more particularly targeted, by the inflatable heating section, to the tissue to be subjected to the thermal treatment, thereby enabling higher temperatures to be applied if desired.
According to a another aspect of the invention, there is provided a thermal treatment apparatus for thermally treating selected tissues of a subject located in or near a body cavity, comprising: a catheter insertable into the subject's body cavity and including a proximal end having an inflatable anchoring section for anchoring the catheter in the body cavity, a distal end to be located externally of the body cavity, and an inflatable heating section adjacent the proximal end to be located near the tissue to be heated; first and second passageways from the distal end to the inflatable heating section for circulating heated fluid through the inflatable heating section but not through the inflatable anchoring section; a first thermal sensor assembly near the inlet end of the first passageway for measuring the temperature of the heated fluid entering the first passageway; and a second thermal sensor assembly near the outlet end of the second passageway for measuring the temperature of the heated liquid exiting from the second passageway.
More particularly, each of the two thermal sensor assemblies includes: a thermal sensor, a metal tube connectable to the respective end of the respective passageway of the catheter to receive the heated fluid flowing therethrough; a metal thermal coupling member formed with a recess on one face for receiving the thermal sensor therein, a recess on the opposite face complementary to the shape of the metal tube for receiving the metal tube therein, and a relatively thin web between the two recesses; and a cover pressing the metal tube to the metal thermal coupling member.
According to a still further aspect of the invention, there is provided a liquid heater which is particularly useful in such thermal treatment apparatus and including a heating block formed with a semi-spherical cavity; a container defining a liquid reservoir and also formed with a semispherical wall removably receivable in the cavity of the heating block; a cover attached to the container; a liquid inlet tube passing through the cover for inletting a liquid into the container to be heated by the heating block; and a liquid outlet tube passing through the cover for outletting a liquid from the container after having been heated by the heating block.
According to a further aspect of the invention, there is provided a peristaltic pump particularly useful in thermal treatment apparatus, which peristaltic pump includes a housing formed with a cylindrical cavity; and a rotor rotatably mounted within the cavity and carrying rollers engageable with a peristaltic tube insertable into the cavity for pressing the peristaltic tube against a wall of the housing in order to pump a liquid through the peristaltic tube during the rotation of the rotor; the wall of the housing including a skirt depending from a lid removably received over the cylindrical cavity; the depending skirt extending less than the circumference of the lid to produce an interruption in the housing wall against which the peristaltic tube is pressed by the rollers of the rotor.
Further features and advantages of the invention will be apparent from the description below.
The invention is herein described, by way of example only, with reference to the accompanying drawings, wherein:
FIG. 1 is a block diagram illustrating the main components of a thermal treatment apparatus constructed in accordance with the present invention;
FIG. 2 is a view, partially in longitudinal section diagrammatically illustrating one form of catheter constructed in accordance with the present invention for use in the thermal treatment apparatus of FIG. 1;
FIG. 3 is a view, partially in longitudinal section and rotated 90° with respect to FIG. 2, illustrating the catheter of FIG. 2;
FIGS. 4, 5 and 6 are transverse sectional views along lines IV—IV, V—V and VI—VI in FIG. 3;
FIG. 7 is a bottom view illustrating one form of liquid heater constructed in accordance with the invention for use in the thermal treatment apparatus of FIG. 1;
FIG. 7a is a sectional view along line VIIa—VIIa of FIG. 7;
FIG. 8 is a longitudinal sectional view along line VIII—VIII of FIG. 9, and FIG. 9 is a transverse sectional view along line IX—IX of FIG. 8, of one form of peristaltic pump constructed in accordance with the invention, FIG. 9a being a fragmentary detail view along line IXa—IXa of FIG. 9;
FIG. 10 is a transverse sectional view along line X—X of FIG. 11, and FIG. 11 is a longitudinal sectional view along line XI—XI of FIG. 10, illustrating one form of thermal sensor assembly constructed in accordance with the invention for use in the thermal treatment apparatus of FIG. 1.
The thermal treatment apparatus diagrammatically illustrated in FIG. I includes a catheter 2 insertable into a subject's body cavity to be treated thermally. In the example to be described below, the heat is applied to treat the prostate. The catheter 2 would therefore be inserted into the subject's urethra, such that one end of the catheter is anchored in the subject's bladder. This locates a heating section of the catheter in the subject's prostate.
The thermal treatment apparatus illustrated in FIG. 1 further includes a heater 4 for heating a fluid, in this case a liquid such as water, to be circulated in a closed circuit through the heating section of the catheter by means of a pump 6, The temperature of the heating liquid inletted from pump 6 into the catheter 2 is measured by a thermal sensor assembly 8, and the temperature of the liquid exiting from the catheter 2 to the heater 4 is measured by another thermal sensor assembly 10. The illustrated apparatus further includes a controller 12 which controls both the heater 4 and the pump 6 in response to the temperature sensed by sensor assemblies 8 and 10 and another sensor (to be described below) in the heater 4.
The construction of the catheter 2 is shown in FIGS. 2-6; the construction of the liquid heater 4 is shown in FIGS. 7 and 7a; the construction of the pump 6 is shown in FIGS. 8, 9 and 9 a; and the construction of the two thermal sensor assemblies 8 and 10 is shown in FIGS. 10 and 11.
The catheter 2, as shown in FIGS. 2-6, includes a long slender tube 20 formed with an inflatable anchoring section 21 at the proximal end for anchoring the catheter in the subject's bladder, and thereby for locating an inflatable cylindrical heating section 22 extending through the subject's prostate when the catheter is so anchored. The opposite end of the catheter, called the distal end, is to be located externally of the subject's urethra so as to be readily accessible for inflating the proximal anchoring section 21 and for inflating and circulating a heating liquid through the inflatable heating section 22.
The heating liquid is circulated through the inflatable heating section 22 via two passageways 24 a, 24 b having an inlet 25 and an outlet 26 at the distal end 23 of the catheter. The inflatable anchoring section 21 of the catheter is inflated by an unheated fluid, such as air, introduced via an inlet 27 at the distal end 23 and communicating with the anchoring section 21 via the third passageway 28 and an opening 29.
The portion of the catheter from the distal end 23 to the inflatable heating section 22 is thermally insulated from the subject's tissue by means of outer chambers 30, 30 a and 30 b enclosing passageways 24 a, 24 b, referred to generically by numeral 24, through which the heating liquid is circulated to the heating section 22. One of these chambers communicates with passageway 28 through which unheated air is applied to inflate the anchoring section 21.
The catheter also includes an extension 31 at the proximal end, which extension is received within the subject's bladder. Extension 31 is formed with an opening 32 for draining the subject's bladder via a passageway 33 passing through the length of the catheter and terminating in an outlet 34 at the distal end 23 of the catheter for connection to a drain. Extension 31 and its passageway 33 may also be used for introducing a drug into the bladder if desired.
The Heater 4 (FIG. 7)
The liquid heater 4, as more particularly illustrated in FIG. 7, includes a heating block 40 made of a good heat-conducting material, such as aluminum. Heating block 40 is of dome shape to define a smoothly curved semi-spherical cavity 41, and is integrally formed with four perpendicular ribs 42. A plurality of electrical heating elements 43, and one or more thermal sensors 44, are encased within the heating block 40. As seen in FIG. 7, an electrical heating element 43 is encased in each of the four ribs 42, and thermal sensor 44 is encased in each of the two opposite sides of the heating block, midway between two heating elements 43. The dome-shaped section of the heating block is relatively thin, as shown at 45 in FIG. 7a, to thereby reduce its thermal mass.
The heating block 40 illustrated in FIG. 7a further includes a removable container 50 serving as a water reservoir and formed with a complementary-curved wall 51, i.e., of semi-spherical configuration corresponding to the semi-spherical configuration of cavity 41. The semi-spherical wall 51 of container 50, however, is of slightly smaller dimensions than the heating block cavity 41 so as to provide a small gap 52 adapted to receive a small quantity of a liquid 53 to provide a good thermal coupling between block 40 and container wall 51. The semi-spherical shape of the container wall 51 permits it to be of a thin- wall construction and therefore sufficiently inexpensive so as to be disposable after one-time use. The thinness of the plastic wall also provides good thermal conductivity between heating block 40 and the interior of container 50.
Container 50 further includes a cover 54, preferably bonded by an adhesive or solvent or welded to the curved wall 51 of the container. Cover 54 is formed with a reentry tube 55 substantially centrally of the cover for receiving an inlet tube 56 which inlets into the container the liquid to be heated by the heating block 40. A second reentry tube 57 is formed in cover 54 laterally Of reentry tube 55, for receiving the outlet tube 58 which outlets the liquid from the container. The inlet reentry tube 55 extends from cover 54 substantially to the bottom of the container 50, whereas the outlet reentry tube 57 terminates close to the top of the container 50. This arrangement provides a relatively large residence time and contact surface for heating the liquid as it is circulated within container 50 from the inlet 56 to the outlet 58.
The Peristaltic Pump 6 (FIGS. 8, 9 and 9 a)
Pump 6 in FIG. 1 is a peristaltic pump as more particularly illustrated in FIGS. 8, 9 and 9 a. It includes a housing 60 formed with a cylindrical cavity 61. Disposed within cylindrical cavity 61 is a rotor 62 connected by a drive shaft 63 to a gear motor (not shown) and including a pair of spaced discs 64 a, 64 b rotatably mounting between them a plurality (3) of rollers 65 within cavity 61. Also located within the cylindrical cavity 61 is a peristaltic tube 66 which is engageable by the roller 65 for pumping the liquid through the tube during the rotation of rotor 62. Assuming rotor 62 is rotated counter-clockwise in FIG. 9, the liquid will be pumped through the peristaltic tube 66 from an inlet nipple 67 to an outlet nipple 68.
As shown in FIG. 8, housing 60 further includes a lid 70 formed with a large central opening 71 for accommodating disc 64 of the rotor 62. Lid 70 is formed with a depending skirt 72 which extends into the cylindrical cavity 61 such that the peristaltic tube 66 is located between the inner surface of skirt 72 and the rollers 65. Skirt 72 extends only for a part of the circumference of the lid, e.g., from 160° to 200°, to accommodate the inlet and outlet ends of the peristaltic tube 66. As shown in FIG. 9, skirt 72 extends slightly more than 180°; also, its leading edge 73 and its trailing edge 74 are tapered to provide a gradual application of the pressure to the peristaltic tube by the roller 65, and a gradual release of the pressure.
Housing 60 is of polygonal, preferably square, cross-section to provide a flat surface 60 a. Lid 70 is provided with a depending pin 75 in contact with the outer flat surface 60 a of housing 60 (see FIGS. 9 and 9a) to prevent rotation of the lid during the rotation of the rotor 62.
The illustrated construction, including the depending skirt 72, facilitates the assembly of the peristaltic pump with the peristaltic tube 66 between the skirt and the rollers 65. Thus, with the lid removed the peristaltic tube 66 may be conveniently applied around the rollers 65. The lid 70 may then be applied with its skirt 72 received between the peristaltic tube 66 and the inner surface of the cylindrical cavity 61 formed in housing 60, so as to squeeze the tube between it and the rollers 65. For this purpose, the lower edge of skirt 72 is tapered, as shown at 76 in FIGS. 8 and 9a, to facilitate the application of the skirt.
The foregoing construction not only facilitates the assembly of the peristaltic pump, but also covers the rollers 65 to minimize exposure to a person's fingers or the like. In addition, the thickness of skirt 72 influences the outlet pressure produced by the pump, so that lids 70 with different thickness skirts 72 may be provided to provide different outlet pressures. In addition, the inner surface of the skirt 72 may be provided with one or more grooves, as shown at 77 in FIG. 9, to produce a pulsatile output.
The thermal sensors assemblies 8, 10
The thermal sensor assemblies 8, 10 are more particularly illustrated in FIGS. 10 and 11. They are both enclosed within a common housing 80 in the shape of an “H” and closed by a common cover 31. Thermal sensor assembly 8 near the inlet end of the catheter 2 includes a thermal sensor element 82 received within a rectangular recess formed in a metal thermal coupling member 83. The opposite face of the coupling member is formed with a recess for receiving a metal tube 84 connectable to an inlet tube 85 near the inlet end of the catheter. Thermal sensor assembly 10 similarly includes a thermr al sensor element 86 received within a recess formed in another thermal coupling member 87. The opposite face of member 87 is similarly formed with a recess for receiving a metal tube 88 adapted to be coupled to an outlet tube 89 near the outlet end of the catheter. Electrical connections are made to the two thermal sensor elements 82 and 86 via a cable 90 leading to the controller 12 in FIG. 1.
The two thermal coupling members 83, 87, as well as the two tubes 84, 88, are of a metal, such as stainless steel, having relatively good thermal conductivity. The coupling members 83, 87 include relatively thin web portions 83 a, 87 a, respectively, between the thermal sensor elements 82, 86 and the metal tubes 84, 88, so as to provide a good thermal coupling between the liquid flowing through the two metal tubes and their respective thermal sensor elements. The cover 81, fixed to the common H-shaped housing 80 in any suitable manner, presses the metal tubes 94, 88 firmly against their respective metal coupling members 83, 87.
The overall operation of the thermal treatment apparatus illustrated in the drawings is as follows:
The catheter 2 is inserted into the urethra of the subject until the inflatable anchoring section 21 at the proximal end passes through the subject's bladder neck. An unheated fluid, preferably air, is introduced via inlet 27 and passageway 28 into the interior of the anchoring section 21 to inflate it. This anchors section 21 in the subject's bladder, wherepon the cylindrical heating section 22 of the catheter extends through the subject's prostate.
A heating fluid, such as water, is then pumped from the container 50 via pump 6 into the inlet 25 of passageway 24 a, to fill the catheter and to inflate the cylindrical heating section 22 of the catheter. Additional water is added to the catheter (e.g., via a separate inlet in the connector connecting the catheter to the closed circuit) to completely fill the closed circuit including container 50 and the catheter 2. The water heated within container 50 is circulated by the peristaltic pump 6 through the closed circuit including the cylindrical heating section 22 of the catheter.
During the circulation of the heating liquid, the sensor assemblies 8, 10 sense the temperature of the heating liquid near the inlet and outlet ends of the catheter, respectively. These sensor assemblies, together with the thermal sensors 44 in the electrical heater 4, control the controller 12 to maintain the desired temperature. Only the inflated heating section 22 of the catheter is effective to heat tissue, because of the thermal insulation provided by the unheated air within the anchoring section 21 of the catheter, and within chambers 30 of the remaining portion of the catheter. Accordingly, the liquid applied to the inflatable heating section 22 may be heated to a relatively high temperature for application to the tissue within the prostate, with less danger of unduly heating other tissue contacted by the catheter. The inflation of the heating section 22 of the catheter also presses that section firmly against the tissue to be thermally treated thereby further enhancing the heating effects.
Drain opening 32 at the proximal end of the catheter, and passageway 33 through the catheter, provide a drain for the bladder liquids or enable the introduction of a drug into the bladder.
While the invention has been described with respect to one preferred embodiment, it will be appreciated that many other variations, modifications and applications of the invention may be made.
|Patente citada||Fecha de presentación||Fecha de publicación||Solicitante||Título|
|US612724||4 Jun 1897||18 Oct 1898||Bert j|
|US827099||8 Jul 1905||31 Jul 1906||Frederick Hofmann||Medical device.|
|US899477||26 Oct 1907||22 Sep 1908||William Bryant||Dilator and applicator.|
|US1011606||5 Mar 1910||12 Dic 1911||Jacob A Fulton||Appliance for subjecting portions of the human system to heat or cold.|
|US1393153||14 Ene 1921||11 Oct 1921||Fox Morris John||Device for treatment by temperature|
|US1584464||7 Mar 1923||11 May 1926||Maranville Clarence H||Medicinal applicator|
|US1620929||5 Feb 1925||15 Mar 1927||Wallerich George W||Heat-therapy method and means|
|US1652954||29 Mar 1926||13 Dic 1927||Pierce Charles C||Prostate applicator|
|US1690995||28 Dic 1927||6 Nov 1928||Monte Lloyd Corp||Anorectal dilator|
|US1764838||3 Nov 1928||17 Jun 1930||Newton H Horne||Hydraulic pulsator|
|US1786373||30 Nov 1929||23 Dic 1930||Walker Ralph C||Electrically-heated therapeutical appliance|
|US1827306||14 Sep 1925||13 Oct 1931||Fischer & Co H G||Electrode|
|US1904020||26 Oct 1929||18 Abr 1933||Wappler Reinhold H||Temperature controlling apparatus|
|US2024301||21 Sep 1934||17 Dic 1935||Norwood Robert R||Surgical appliance|
|US2026747||16 Mar 1935||7 Ene 1936||William P B Nemzek||Gravity thermal dilator|
|US2043083||8 Jul 1932||2 Jun 1936||Charles Wappler Frederick||Therapeutic electrode and plug therefor|
|US2058780||28 Mar 1931||27 Oct 1936||Elliott Charles Robert||Thermo-therapeutical method and apparatus|
|US2074634||27 May 1935||23 Mar 1937||Henri Ackermann||Tubular heating device for gynecological purposes|
|US2076638||25 Abr 1936||13 Abr 1937||Haynos John J||Prostate gland massaging and variable temperature applicator|
|US2077453||29 Mar 1934||20 Abr 1937||American Anode Inc||Therapeutical appliance|
|US2078786||17 Dic 1934||27 Abr 1937||Mason Wood Glen||Applicator and control means therefor|
|US2103371||21 Abr 1934||28 Dic 1937||Kleckner Arthur C||Therapeutic device|
|US2168427||25 May 1937||8 Ago 1939||Mcconkey Walter N||Thermal dilator|
|US2190383||29 Ago 1936||13 Feb 1940||Newman Louis B||Therapeutic apparatus|
|US2190384||6 Jul 1937||13 Feb 1940||Newman Louis B||Therapeutic bag|
|US2192768||20 Jun 1939||5 Mar 1940||Cross Thomas J||Therapeutical heating device|
|US2466042||26 Ago 1947||5 Abr 1949||Nechtow Mitchell J||Internal heat-treatment device|
|US2734508||29 Mar 1954||14 Feb 1956||Kozinski|
|US2777442||11 Abr 1955||15 Ene 1957||Joseph Zelano||Nasal filter|
|US2777445||12 Jul 1952||15 Ene 1957||Electronic Medical Foundation||Electrical therapeutical device for internal application|
|US2849001||17 Oct 1955||26 Ago 1958||Vincent J Oddo||Haemostatic catheter|
|US3154077||4 Jun 1962||27 Oct 1964||Joseph P Cannon||Hemostatic device for anal surgery|
|US3227154||11 May 1962||4 Ene 1966||Galen B Cook||Diagnostic bag with impressionable outer surface and method of using it|
|US3369549||5 Oct 1965||20 Feb 1968||Thomas A. Armao||Capsule probe having thermoelectric heat exchange means therein|
|US3417746||27 Feb 1968||24 Dic 1968||Welch Allyn Inc||Illuminating endoscope with disposable elements|
|US3625793||23 Sep 1969||7 Dic 1971||David S Sheridan||Balloon-type catheters and method of manufacture|
|US3645265||25 Jun 1969||29 Feb 1972||Majzlin Gregory||Intrauterine cauterizing device|
|US3811450||25 Oct 1972||21 May 1974||P Lord||Catheters|
|US3848602||19 Abr 1972||19 Nov 1974||Gutnick Morton||Abortion facilitating device and process|
|US3848607||8 Jun 1973||19 Nov 1974||M Clair||Therapeutic apparatus|
|US4091672||9 Jun 1977||30 May 1978||Sarns, Inc.||Temperature probe and connector|
|US4112943||26 Mar 1975||12 Sep 1978||Adams Robbie J||Therapeutic assembly|
|US4137922||21 May 1975||6 Feb 1979||Ortho Pharmaceutical Corp.||Dilator for cervical canal|
|US4143649||24 Ene 1977||13 Mar 1979||George Foti||Pump for closed circulation system|
|US4160455||13 Jul 1977||10 Jul 1979||Ferranti Limited||Heater for heating fluid in a body cavity|
|US4185948||30 Nov 1977||29 Ene 1980||Maguire Stephen B||Peristaltic pump construction|
|US4244377||19 Oct 1978||13 Ene 1981||Grams Guenter A||Ear probe for use in closed-loop caloric irrigation|
|US4335726||11 Jul 1980||22 Jun 1982||The Kendall Company||Therapeutic device with temperature and pressure control|
|US4367747||1 Oct 1980||11 Ene 1983||Lothar Witzel||Pneumatic dilatator for introdution into the esophagus|
|US4469103||3 Mar 1982||4 Sep 1984||Barrett Harold F||Method of treating conditions such as tumors in living bodies|
|US4530647||8 Feb 1984||23 Jul 1985||Unolab Co., Ltd.||Peristaltic pump having conical rollers|
|US4552557||21 Oct 1983||12 Nov 1985||Avvari Rangaswamy||Inflatable uterine hemostat|
|US4574752||15 Oct 1984||11 Mar 1986||Marvion E. Reichert, Jr.||Internal combustion engine shutdown device|
|US4610660||18 Dic 1984||9 Sep 1986||The Kendall Company||Method of performing a nephrostomy procedure with connector assembly|
|US4628931||18 May 1984||16 Dic 1986||Barrett Harold F||Medical treatment method|
|US4636195||4 Abr 1985||13 Ene 1987||Harvey Wolinsky||Method and apparatus for removing arterial constriction|
|US4655746||2 Dic 1985||7 Abr 1987||Target Therapeutics||Catheter device|
|US4662368||28 Jun 1985||5 May 1987||Trimedyne Laser Systems, Inc.||Localized heat applying medical device|
|US4671795||19 Nov 1984||9 Jun 1987||Mulchin William L||Permanent/retrievable ureteral catheter|
|US4672962||7 Oct 1985||16 Jun 1987||Cordis Corporation||Plaque softening method|
|US4676258||5 Jun 1986||30 Jun 1987||Kureha Kagaku Kogyo Kabushiki Kaisha||Device for hyperthermia|
|US4686965||31 Ene 1986||18 Ago 1987||Richard Wolf Gmbh||Instrument for endoscopic operations|
|US4686985||24 Abr 1986||18 Ago 1987||Lottick Edward A||Anal dilator and occluder|
|US4709698||14 May 1986||1 Dic 1987||Thomas J. Fogarty||Heatable dilation catheter|
|US4710169||11 Dic 1985||1 Dic 1987||Christopher T Graham||Urinary catheter with collapsible urethral tube|
|US4754752||27 Jul 1987||5 Jul 1988||Robert Ginsburg||Vascular catheter|
|US4787388||26 Nov 1986||29 Nov 1988||Schneider - Shiley Ag||Method for opening constricted regions in the cardiovascular system|
|US4793351||15 Jun 1987||27 Dic 1988||Mansfield Scientific, Inc.||Multi-lumen balloon catheter|
|US4793352||11 May 1987||27 Dic 1988||Eichenlaub John E||Limited heat transfer device and method|
|US4799479||8 Ene 1987||24 Ene 1989||The Beth Israel Hospital Association||Method and apparatus for angioplasty|
|US4819751||16 Oct 1987||11 Abr 1989||Baxter Travenol Laboratories, Inc.||Valvuloplasty catheter and method|
|US4823812||5 May 1987||25 Abr 1989||Biodan Medical Systems Ltd.||Applicator for insertion into a body opening for medical purposes|
|US4824436||21 Abr 1987||25 Abr 1989||Harvey Wolinsky||Method for the prevention of restenosis|
|US4832691||12 Mar 1987||23 May 1989||Lothar Witzel||Pneumatic bougie, particularly for treatment of stenoses|
|US4860744||2 Nov 1987||29 Ago 1989||Raj K. Anand||Thermoelectrically controlled heat medical catheter|
|US4865047||30 Jun 1988||12 Sep 1989||City Of Hope||Hyperthermia applicator|
|US4893623||20 Nov 1987||16 Ene 1990||Advanced Surgical Intervention, Inc.||Method and apparatus for treating hypertrophy of the prostate gland|
|US4932938||5 May 1989||12 Jun 1990||Medical Engineering Corporation||Urethral indwelling catheter with incontinence control|
|US4932956||4 May 1989||12 Jun 1990||American Medical Systems, Inc.||Prostate balloon dilator|
|US4946449||18 Dic 1986||7 Ago 1990||Davis Jr Richard C||Indwelling urethral catheter system and method|
|US4949718||9 Sep 1988||21 Ago 1990||Gynelab Products||Intrauterine cauterizing apparatus|
|US4950227||7 Nov 1988||21 Ago 1990||Boston Scientific Corporation||Stent delivery system|
|US4955859||7 Jul 1989||11 Sep 1990||C. R. Bard, Inc.||High-friction prostatic stent|
|US4967765||28 Jul 1988||6 Nov 1990||Bsd Medical Corporation||Urethral inserted applicator for prostate hyperthermia|
|US4973301||11 Jul 1989||27 Nov 1990||Israel Nissenkorn||Catheter and method of using same|
|US4995872||4 Oct 1989||26 Feb 1991||Ferrara Janice J||Expandable catheter and bridge device|
|US5007437||19 Abr 1990||16 Abr 1991||Mmtc, Inc.||Catheters for treating prostate disease|
|US5019075||31 Jul 1990||28 May 1991||The Beth Israel Hospital||Method and apparatus for angioplasty|
|US5035694||15 May 1989||30 Jul 1991||Advanced Cardiovascular Systems, Inc.||Dilatation catheter assembly with heated balloon|
|US5041092||30 Oct 1990||20 Ago 1991||Medical Engineering Corporation||Urethral indwelling catheter with magnetically controlled drainage valve and method|
|US5045056||15 Sep 1989||3 Sep 1991||Behl Robert S||Method and device for thermal ablation of hollow body organs|
|US5059169||24 Jul 1990||22 Oct 1991||C. R. Bard, Inc.||High-friction prostatic stent|
|US5061241||8 Feb 1991||29 Oct 1991||Stephens Jr Harry W||Rapid infusion device|
|US5084044||14 Jul 1989||28 Ene 1992||Ciron Corporation||Apparatus for endometrial ablation and method of using same|
|US5098374||2 Sep 1988||24 Mar 1992||Engineers & Doctors A/A||Device for the placing of a partial catheter in a body cavity|
|US5105808||9 Ago 1990||21 Abr 1992||Gynelab Products||Intrauterine cauterizing method|
|US5112306||27 Dic 1989||12 May 1992||American Medical Systems, Inc.||Method and apparatus for valving body fluids|
|US5151100||3 Jul 1990||29 Sep 1992||Boston Scientific Corporation||Heating catheters|
|US5159925||28 Ene 1991||3 Nov 1992||Gynelab, Inc.||Cauterizing apparatus and method for laparoscopic cholecystostomy, gallbladder ablation and treatment of benign prostate hypertrophy|
|US5176626||15 Ene 1992||5 Ene 1993||Wilson-Cook Medical, Inc.||Indwelling stent|
|US5188596||27 Sep 1990||23 Feb 1993||Mentor Corporation||Transparent prostate dilation balloon and scope|
|US5195565||11 Oct 1991||23 Mar 1993||Elopak Systems A.G.||Variable stroke lifter system|
|US5195965||7 Mar 1991||23 Mar 1993||Shantha Totada R||Method and apparatus for localized treatment of human viral infections and cancers|
|US5220927||15 Mar 1990||22 Jun 1993||Bsd Medical Corporation||Urethral inserted applicator for prostate hyperthermia|
|US5234004||12 Mar 1991||10 Ago 1993||Technomed International||Method and apparatus for the surgical treatment of tissues by thermal effect, and in particular the prostate, using a urethral microwave-emitting probe means|
|US5257977||14 Mar 1991||2 Nov 1993||Argomed Ltd.||Technique for localized thermal treatment of mammals|
|US5269758||29 Abr 1992||14 Dic 1993||Taheri Syde A||Intravascular catheter and method for treatment of hypothermia|
|US5269802||10 Sep 1991||14 Dic 1993||Garber Bruce B||Prostatic stent|
|US5281213||16 Abr 1992||25 Ene 1994||Implemed, Inc.||Catheter for ice mapping and ablation|
|US5286259||18 Feb 1992||15 Feb 1994||Diagnostic Devices Group Limited||Dual-diameter multifunction catheter|
|US5306241||13 Dic 1991||26 Abr 1994||Samples Charles R||Method of catheterization on and bladder drainage|
|US5312343||23 Nov 1990||17 May 1994||Michael Krog||Device for segmental perfusion and aspiration of colon and rectum|
|US5314443||21 Ene 1993||24 May 1994||Meadox Medicals, Inc.||Prostate balloon dilatation catheter|
|US5322501||2 Oct 1992||21 Jun 1994||Mahmud Durrani Ayaz||Continent urethral stent for treating and preventing urethral stricture after surgery|
|US5328471||4 Ago 1993||12 Jul 1994||Endoluminal Therapeutics, Inc.||Method and apparatus for treatment of focal disease in hollow tubular organs and other tissue lumens|
|US5372600||10 May 1993||13 Dic 1994||Instent Inc.||Stent delivery systems|
|US5385540||26 May 1993||31 Ene 1995||Quest Medical, Inc.||Cardioplegia delivery system|
|US5391196||18 Jun 1993||21 Feb 1995||Devonec; Marian||Method for therapeutic treatment of an obstructed natural canal|
|US5403281||25 Sep 1992||4 Abr 1995||Minnesota Mining And Manufacturing Company||Inline heat exchanger and cardioplegia system|
|US5419763||4 Ene 1994||30 May 1995||Cortrak Medical, Inc.||Prostatic drug-delivery catheter|
|US5431648||10 Nov 1992||11 Jul 1995||Fondazione Centro S. Raffaele Del Monte Tabor||Radiating device for hyperthermia|
|US5439446||30 Jun 1994||8 Ago 1995||Boston Scientific Corporation||Stent and therapeutic delivery system|
|US5451218||2 Mar 1994||19 Sep 1995||Moore; Patrick S.||Urinary drainage device|
|US5478349||28 Abr 1994||26 Dic 1995||Boston Scientific Corporation||Placement of endoprostheses and stents|
|US5480417||24 May 1993||2 Ene 1996||Technomed Medical Systems||Method and apparatus for the surgical treatment of tissues by thermal effect, and in particular the prostate, using a urethral microwave-emitting probe means|
|US5496271||16 Jun 1993||5 Mar 1996||American Medical Systems, Inc.||Combined hyperthermia and dilation catheter|
|US5496311||2 May 1994||5 Mar 1996||Boston Scientific Corporation||Physiologic low stress angioplasty|
|US5499994||28 Abr 1994||19 Mar 1996||American Medical Systems, Inc.||Dilation device for the urethra|
|US5509929||6 Oct 1992||23 Abr 1996||Technomed Medical Systems||Urethral probe and apparatus for the therapeutic treatment of the prostate by thermotherapy|
|US5514092||8 Ago 1994||7 May 1996||Schneider (Usa) Inc.||Drug delivery and dilatation-drug delivery catheters in a rapid exchange configuration|
|US5514095||4 Abr 1994||7 May 1996||Haemonetics Corporation||Apparatus for heating, filtering and eliminating gas from biological fluids|
|US5514178||27 May 1994||7 May 1996||Synthelabo||Prosthesis for bodily canal|
|US5518498||7 Oct 1993||21 May 1996||Angiomed Ag||Stent set|
|US5571153||25 Mar 1996||5 Nov 1996||Wallst+E,Acu E+Ee N; Hans I.||Device for hyperthermia treatment|
|US5578008||14 Oct 1993||26 Nov 1996||Japan Crescent, Inc.||Heated balloon catheter|
|US5588965||7 Mar 1995||31 Dic 1996||American Medical Systems, Inc.||Device for slowly dilating the prostatic urethra|
|US5609583||21 Sep 1995||11 Mar 1997||Hakki; A-Hamid I.||Collapsible catheter|
|US5624392||8 Ago 1994||29 Abr 1997||Saab; Mark A.||Heat transfer catheters and methods of making and using same|
|US5685847||27 Jul 1995||11 Nov 1997||Boston Scientific Corporation||Stent and therapeutic delivery system|
|US5718686||2 Jul 1996||17 Feb 1998||Urocath Corporation||Anchoring system and method for indwelling urethral catheter|
|US5766209||16 Feb 1994||16 Jun 1998||Devonec; Marian A.||Prosthesis intended for the treatment of a natural lumen or tract, in particular an endo-urethral prosthesis|
|US5785641||8 May 1996||28 Jul 1998||Urocath Corporation||Male indwelling urethral catheter sizing system and insertion method|
|US5843144||26 Jun 1995||1 Dic 1998||Urologix, Inc.||Method for treating benign prostatic hyperplasia with thermal therapy|
|US5876517||28 Oct 1997||2 Mar 1999||Atotech Deutschland Gmbh||Chromate-plating bath and process for finishing zinc zinc alloy or cadmium surfaces|
|US5916195||4 Feb 1998||29 Jun 1999||Argomed Ltd.||Internal catheter|
|DE895046C||2 Oct 1948||7 Dic 1953||Ulrich W Doering||Medizinisches Geraet zur Waermebehandlung innerer Organe und Einfuehrung in Koerperhoehlen|
|EP0105677B1||22 Sep 1983||10 Dic 1986||Kureha Kagaku Kogyo Kabushiki Kaisha||Endotract antenna device for hyperthermia|
|EP0341988B1||9 May 1989||13 Ene 1993||American Medical Systems, Inc.||Prostate balloon dilator|
|EP0449472B1||18 Mar 1991||6 Dic 1995||Argomed Ltd||An apparatus for localized thermal treatment of mammals|
|EP0543309B1||16 Nov 1992||2 Nov 1995||Engel, Konrad Dr.med.||Device for the treatment of male urinary incontinence|
|EP0672401B1||6 Mar 1995||25 Sep 2002||AGROMED Ltd.||Thermal treatment apparatus|
|EP0733379B1||20 Mar 1996||1 Sep 2004||ContiCare Medical, Inc.||Self-cleansing bladder drainage device|
|EP0753289B1||2 Jul 1996||26 Nov 2003||Marian Devonec||Fractionable catheter|
|EP0790041B1||17 Jul 1996||6 May 2004||Eckhard Dr. Alt||Implantable vascular and endoluminal stents|
|EP0801938B1||16 Abr 1997||23 Jun 2004||Wit IP Corporation||Thermal treatment apparatus|
|FR439636A||Título no disponible|
|FR774318A||Título no disponible|
|FR1328484A||Título no disponible|
|FR1550927A||Título no disponible|
|GB151004A||Título no disponible|
|GB287772A||Título no disponible|
|GB315971A||Título no disponible|
|GB317604A||Título no disponible|
|GB658662A||Título no disponible|
|GB1563795A||Título no disponible|
|JP1263440A||Título no disponible|
|JP6189330A||Título no disponible|
|JP6343661A||Título no disponible|
|JP52104397A||Título no disponible|
|JP60235940A||Título no disponible|
|JP62005045A||Título no disponible|
|JP63222759A||Título no disponible|
|JPS5616437B2||Título no disponible|
|1||Abstract, Kaver et al., "A New Transurethral Water-Induced Thermal (WIR) Dilation Device for the Treatment of BPH," presented at SIU, Sydney, Australia, Poster Session 26, BPH, Thermotherapy and Hypothermia (Sep. 1994).|
|2||European Search Report, Application No. EP 95 10 3189 dated Sep. 26, 1995.|
|3||European Search Report, Application No. EP 97 10 6282 dated Dec. 7, 1999.|
|Patente citante||Fecha de presentación||Fecha de publicación||Solicitante||Título|
|US6655934 *||20 Mar 2002||2 Dic 2003||Innovent, L.L.C.||Inverted peristaltic pumps and related methods|
|US6758857 *||13 Nov 2001||6 Jul 2004||Acmi Corporation||Treatment catheters with thermally insulated regions|
|US7306586||30 Dic 2003||11 Dic 2007||Opmi Funding Corporation||Continuous drainage adaptor|
|US7615046 *||25 Oct 2006||10 Nov 2009||Sobhy Shehata||Apparatus and method for the controlled hydrodistention of the urinary bladder|
|US7777130||18 Jun 2007||17 Ago 2010||Vivant Medical, Inc.||Microwave cable cooling|
|US8093500||14 Jun 2010||10 Ene 2012||Vivant Medical, Inc.||Microwave cable cooling|
|US8167870 *||1 Oct 2009||1 May 2012||Sobhy Shehata||Apparatus and method for the controlled hydrodistention of the urinary bladder|
|US20020082556 *||13 Nov 2001||27 Jun 2002||Iulian Cioanta||Treatment catheters with thermally insulated regions|
|US20040208764 *||15 Abr 2004||21 Oct 2004||Richard Wolf Gmbh||Medical tubing pump|
|US20050148999 *||30 Dic 2003||7 Jul 2005||Opmi Funding, Inc.||Continuous drainage adaptor|
|US20070005049 *||29 Jun 2006||4 Ene 2007||Comben Richard H||Apparatus and Method of Treating Urinary Incontinence by Heating Urethra|
|US20080172041 *||25 Oct 2006||17 Jul 2008||Sobhy Shehata||Apparatus and method for the controlled hydrodistention of the urinary bladder|
|US20100016839 *||1 Oct 2009||21 Ene 2010||Sobhy Shehata||Apparatus and method for the controlled hydrodistention of the urinary bladder|
|US20100243287 *||30 Sep 2010||Vivant Medical, Inc.||Microwave Cable Cooling|
|US20110208180 *||25 Feb 2010||25 Ago 2011||Vivant Medical, Inc.||System and Method for Monitoring Ablation Size|
|EP1469201A2 *||11 Feb 2004||20 Oct 2004||Richard Wolf GmbH||Peristaltic pump for medical purposes|
|EP1610739A2 *||16 Mar 2004||4 Ene 2006||Elmedical Ltd.||System and method for treating urinary tract disorders|
|Clasificación de EE.UU.||604/113, 604/97.01, 606/28, 604/153|
|Clasificación internacional||A61F2/958, A61B17/00, F04B43/12, A61F7/00, A61B17/22, A61F7/12, A61F7/02, A61B18/00, A61B18/08, F24H1/12|
|Clasificación cooperativa||A61B2018/00101, A61F2007/025, A61F2007/0095, A61F2007/0054, F04B43/1253, A61B18/08, A61M25/10, A61F7/12, A61B2018/00547, A61F7/123, A61B2018/00166, A61F2007/0086, A61B2017/00274, F24H1/121, A61B2017/22038|
|Clasificación europea||A61B18/08, F24H1/12B, A61M25/10, F04B43/12G, A61F7/12, A61F7/12B|
|10 Dic 2002||AS||Assignment|
|24 Feb 2003||AS||Assignment|
|29 Dic 2003||AS||Assignment|
|21 Ene 2004||FPAY||Fee payment|
Year of fee payment: 8
|27 Jul 2005||AS||Assignment|
Owner name: WIT IP CORPORATION, MASSACHUSETTS
Free format text: RELASE OF SECURITY AGREEMENT;ASSIGNOR:ANTARES CAPITAL CORPORATION;REEL/FRAME:016309/0595
Effective date: 20050721
|3 Mar 2008||REMI||Maintenance fee reminder mailed|
|22 Ago 2008||LAPS||Lapse for failure to pay maintenance fees|