USRE39221E1 - Composition comprising a tramadol material and acetaminophen and its use - Google Patents
Composition comprising a tramadol material and acetaminophen and its use Download PDFInfo
- Publication number
- USRE39221E1 USRE39221E1 US10/761,096 US76109604A USRE39221E US RE39221 E1 USRE39221 E1 US RE39221E1 US 76109604 A US76109604 A US 76109604A US RE39221 E USRE39221 E US RE39221E
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- US
- United States
- Prior art keywords
- pharmaceutical composition
- tramadol
- acetaminophen
- mammal
- weight ratio
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Fats And Perfumes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
TABLE 1 | ||
DRUG COMBINATIONS | DOSE (mg/kg, p.o.) | ED50 30 min (95% CI's) |
(Tramadol:APAP) | Tramadol | APAP | analgesia | Tramadol | APAP |
tramadol only | 2 | 0 | 3/15 | ||
3 | 0 | 4/15 | |||
4 | 0 | 14/45 | |||
6 | 0 | 20/45 | 5.5 | ||
8 | 0 | 40/60 | (4.8-6.4) | ||
10 | 0 | 15/15 | |||
16 | 0 | 14/15 | |||
1000:1 | 3.75 | 0.00375 | 1/13 | ||
7.5 | 0.0075 | 8/15 | 7.0 | 0.01 | |
15 | 0.015 | 15/15 | (5.7-8.4) | (0.1-0.1) | |
100:1 | 1.875 | 0.01875 | 0/15 | ||
3.75 | 0.0375 | 4/15 | 6.9 | 0.1 | |
7.5 | 0.075 | 5/15 | (5.2-9.0) | (0.1-0.1) | |
15 | 0/15 | 15/15 | |||
20:1 | 1.875 | 0.09375 | 0.15 | ||
3.75 | 0.1875 | 4/15 | 6.5 | 0.3 | |
7.5 | 0.375 | 7/15 | (5.1-8.3) | (0.3-0.4) | |
15 | 0.75 | 15/15 | |||
3:1 | 3.75 | 1.25 | 3/30 | ||
7.5 | 2.5 | 12/30 | 7.8 | 2.6 | |
15 | 5 | 28/30 | (6.6-9.1) | (2.2-3.0) | |
1:1 | 0.94 | 0.94 | 3/15 | ||
1.875 | 1.875 | 8/30 | |||
3.75 | 3.75 | 14/30 | 3.8 | 3.8 | |
5 | 5 | 12/28 | (3.0-4.8) | (3.0-4.8) | |
7.5 | 7.5 | 24/30 | |||
15 | 15 | 15/15 | |||
1:3 | 3.75 | 11.25 | 7/30 | ||
5 | 15 | 7/15 | 4.7 | 14.2 | |
7.5 | 22.5 | 29/30 | (4.3-5.2) | (12.8-15.7) | |
1:5 | 2.5 | 12.5 | 7/30 | ||
5 | 25 | 8/30 | 4.0 | 19.8 | |
10 | 50 | 30/30 | (3.3-4.7) | (16.7-23.4) | |
1:5.7 | 0.47 | 2.66 | 0/15 | ||
0.94 | 5.313 | 4/15 | |||
1.88 | 10.625 | 1/15 | 4.1 | 23.3 | |
3.75 | 21.25 | 5/15 | (3.0-5.7) | (16.8-32.3) | |
7.5 | 42.5 | 11/15 | |||
15 | 85 | 15/15 | |||
1:19 | 0.94 | 17.813 | 4/30 | ||
1.88 | 36.625 | 10/28 | |||
3.75 | 71.25 | 21/30 | 2.5 | 47.3 | |
5 | 95 | 22/30 | (2.0-3.0) | (38.9-57.5) | |
7.5 | 142.5 | 29/30 | |||
15 | 285 | 15/15 | |||
1:50 | 0.25 | 12.5 | 3/30 | ||
0.5 | 25 | 7/30 | |||
1 | 50 | 9/30 | 1.2 | 61.4 | |
2 | 100 | 19/30 | (1.0-1.5) | (49.0-77.1) | |
4 | 200 | 27/30 | |||
8 | 400 | 30/30 | |||
1:100 | 0.25 | 25 | 3/60 | ||
0.5 | 50 | 12/60 | |||
1 | 100 | 19/60 | 1.1 | 111.3 | |
2 | 200 | 51/60 | (1.0-1.3) | (96.4-128.6) | |
4 | 400 | 55/60 | |||
8 | 800 | 30/30 | |||
1:200 | 0.125 | 25 | 1/60 | ||
0.25 | 50 | 9/60 | |||
0.5 | 100 | 27/60 | 0.6 | 129.7 | |
1 | 200 | 44/60 | (0.6-0.8) | (110.4-152.4) | |
2 | 400 | 48/60 | |||
4 | 800 | 30/30 | |||
1:400 | 0.0625 | 25 | 2/15 | ||
0.125 | 50 | 4/30 | |||
0.25 | 100 | 18/30 | 0.2 | 95.1 | |
0.5 | 200 | 12/15 | (0.2-0.3) | (75.4-119.8) | |
1 | 400 | 28/30 | |||
2 | 800 | 15/15 | |||
1:800 | 0.03125 | 25 | 4/30 | ||
0.0625 | 50 | 9/30 | |||
0.125 | 100 | 15/30 | 0.1 | 77.4 | |
0.25 | 200 | 27/30 | (0.1-0.1) | (62.9-95.2) | |
0.5 | 400 | 30/30 | |||
1:1600 | 0.03125 | 50 | 2/30 | ||
0.0625 | 100 | 14/30 | |||
0.125 | 200 | 22/30 | 0.1 | 125.7 | |
0.25 | 400 | 27/30 | (0.1-0.1) | (102.7-153.8) | |
0.5 | 800 | 30/30 | |||
APAP only | 0 | 30 | 2/15 | ||
0 | 40 | 12/43 | |||
0 | 50 | 1/15 | |||
0 | 60 | 8/30 | |||
0 | 80 | 23/60 | |||
0 | 100 | 13/30 | — | 164.3 | |
0 | 120 | 13/30 | (122.7-219.9) | ||
0 | 160 | 10/30 | |||
0 | 200 | 13/25 | |||
0 | 240 | 14/25 | |||
0 | 400 | 12/15 | |||
0 | 800 | 13/15 | |||
Claims (76)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75592491A | 1991-09-06 | 1991-09-06 | |
CN92112594A CN1071571C (en) | 1991-09-06 | 1992-10-24 | Composition comprising a tramadol material and acetaminophen and its use |
US07/974,865 US5336691A (en) | 1991-09-06 | 1992-11-10 | Composition comprising a tramadol material and acetaminophen and its use |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US07/974,865 Reissue US5336691A (en) | 1991-09-06 | 1992-11-10 | Composition comprising a tramadol material and acetaminophen and its use |
Publications (1)
Publication Number | Publication Date |
---|---|
USRE39221E1 true USRE39221E1 (en) | 2006-08-01 |
Family
ID=36791806
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US07/974,865 Ceased US5336691A (en) | 1991-09-06 | 1992-11-10 | Composition comprising a tramadol material and acetaminophen and its use |
US10/761,096 Expired - Lifetime USRE39221E1 (en) | 1991-09-06 | 2004-01-20 | Composition comprising a tramadol material and acetaminophen and its use |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US07/974,865 Ceased US5336691A (en) | 1991-09-06 | 1992-11-10 | Composition comprising a tramadol material and acetaminophen and its use |
Country Status (17)
Country | Link |
---|---|
US (2) | US5336691A (en) |
EP (1) | EP0566709B3 (en) |
JP (1) | JP3381190B2 (en) |
KR (1) | KR100243956B1 (en) |
CN (1) | CN1071571C (en) |
AT (1) | ATE169498T1 (en) |
AU (1) | AU651247B2 (en) |
CA (1) | CA2095523C (en) |
DE (2) | DE122004000032I2 (en) |
DK (1) | DK0566709T5 (en) |
ES (1) | ES2120451T7 (en) |
HU (1) | HU219332B (en) |
LU (1) | LU91079I2 (en) |
NL (1) | NL300152I2 (en) |
RU (1) | RU2121346C1 (en) |
SG (1) | SG80535A1 (en) |
WO (1) | WO1993004675A1 (en) |
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US20070003618A1 (en) * | 2002-10-25 | 2007-01-04 | Vincent Lenaerts | Sustained-release tramadol formulations with 24-hour efficacy |
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In the United States District Court For The District of New Jersey, Civil Action No. 02-5707 (JCL), Ortho-McNeil Pharmaceutical, Inc. v. Kali Laboratories, Inc.: Rebuttal Expert Report of Richard P. Rozek, Ph.D. (Nov. 19, 2004), with attached exhibits Bates Nos. OMP RR RR 0001 thru, OMP RR RR 0285. |
In the United States District Court For The District of New Jersey, Civil Action No. 02-5707 (JCL), Ortho-McNeil Pharmaceutical, Inc. v. Kali Laboratories, Inc.: Rebuttal Report of Michael Sofocleous (Jul. 19, 2004), with attached exhibits A thru L. |
In the United States District Court For The District of New Jersey, Civil Action No. 02-5707 (JCL), Ortho-McNeil Pharmaceutical, Inc. v. Kali Laboratories, Inc.: Reply Brief in Support of Defendant Kali Laboratories' Motion for Summary Judgment of Invalidity and Noninfringement of U.S. Pat. No. 5,336,691: Claim 6 (Aug. 23, 2004) [Redacted]. |
In the United States District Court For The District of New Jersey, Civil Action No. 02-5707 (JCL), Ortho-McNeil Pharmaceutical, Inc. v. Kali Laboratories, Inc.: Reply Brief in Support of Defendant Kali Laboratories' Motion for Summary Judgment of Invalidity Under the 35 U.S.C. § 102(b) Public Use Bar (Aug. 23, 2004). |
In the United States District Court For The District of New Jersey, Civil Action No. 02-5707 (JCL), Ortho-McNeil Pharmaceutical, Inc. v. Kali Laboratories, Inc.: Rule 56.1 Statement of Undisputed Facts for Defendant Kali Laboratories' Motion for Summary Judgment of Invalidity Under the 35 U.S.C. § 102(b) Public Use Bar (May 28, 2004) [Redacted]. |
In the United States District Court For The District of New Jersey, Civil Action No. 02-5707 (JCL), Ortho-McNeil Pharmaceutical, Inc. v. Kali Laboratories, Inc.: Second Expert Report of Dr. Charles E. Inturrisi (Jul. 15, 2004), 3 pages. |
In the United States District Court For The District of New Jersey, Civil Action No. 02-5707 (JCL), Ortho-McNeil Pharmaceutical, Inc. v. Kali Laboratories, Inc.: Second Expert Report of Howard T. Thaler, Ph.D. (Jul. 19, 2004),[Redacted]. |
In the United States District Court For The District of New Jersey, Civil Action No. 02-5707 (JCL), Ortho-McNeil Pharmaceutical, Inc. v. Kali Laboratories, Inc.: Second Rebuttal Report of Eric Smith, Ph.D. (Oct. 8, 2004), with attached exhibits Bates Nos. ES-RR2-0001 thru ES-RR2-0011 [Redacted]. |
In the United States District Court for the District of New Jersey, Civil Action No. 02-5707 (JCL), Ortho-McNeil Pharmaceutical, Inc. v. Kali Laboratories, Inc.: Supplemental Expert Report of Harry F. Manbeck, Jr. Oct. 11, 2004, 2 pages. |
In the United States District Court For The District of New Jersey, Civil Action No. 02-5707 (JCL), Ortho-McNeil Pharmaceutical, Inc. v. Kali Laboratories, Inc.: Third Expert Report of Donald R. Stanski, M.D. (Oct. 11, 2004), with attached exhibits Bates No. DS-RR2-0001. |
In the United States District Court For The District of New Jersey, Civil Action No. 02-5707 (JCL), Ortho-McNeil Pharmaceutical, Inc. v. Kali Laboratories, Inc.: Third Expert Report of Dr. Charles E. Inturrisi (Sep. 15, 2004), with attached exhibits 16 thru 19. |
In the United States District Court For The District of New Jersey, Civil Action No. 02-5707 (JCL), Ortho-McNeil Pharmaceutical, Inc. v. Kali Laboratories, Inc.: Third Expert Report of Howard T. Thaler, Ph.D. (Sep. 27, 2004). |
In the United States District Court For The District of New Jersey, Civil Action No. 02-5707 (JCL), Ortho-McNeil Pharmaceutical, Inc. v. Kali Laboratories, Inc.: vol. 1A of Materials Supporting Ortho-McNeil's Oppositions to Kali's Motions for Summary Judgment: Declaration of Jeffrey P. Kushan (Part 1 of 2),with attachments 1 thru 9, Jul. 21, 2004, vol. 1B of Materials Supporting Ortho-McNeil's Oppositions to Kali's Motions for Summary Judgment: Declaration of Jeffrey P. Kushan (Part 2 of 2) with attachments 10 thru 30, vol. 1C pf Materials Supporting Ortho-McNeil's Oppositions to Kali's Motion for Summary Judgment-with attachments Tabs 1 thru 4 (all dated on or about Jul. 21, 2004) [Redacted]. |
In the United States District Court for the District of New Jersey, Civil Action No. 04-886(HAA), Ortho-McNeil Pharmaceutical, Inc., v. Teva Pharmaceutical Industries Ltd., and Teva Pharmaceuticals USA, Inc. Rule 56.1 Statement of Undisputed Material Facts in for Defendants Teva Pharmaceutical Industries Ltd. And Teva Pharmaceutical USA, Inc.'s Motion for Summary Judgment of Invalidity and Noninfringement of U.S. Pat. No. 5,336,691: Claim 6 (Jan. 18, 2005) [Redacted]. |
In the United States District Court for the District of New Jersey, Civil Action No. 04-886(HAA), Ortho-McNeil Pharmaceutical, Inc., v. Teva Pharmaceutical Industries Ltd., and Teva Pharmaceuticals USA, Inc., Brief in Support of Teva Pharmaceutical Industries Ltd. And Teva Pharmaceutical USA, Inc.'s Motion for Summary Judgment of Invalidity and Noninfringement of U.S. Patent No. 5,336,691: Claim 6 (Jan. 18, 2005) [Redacted]. |
In the United States District Court for the District of New Jersey, Civil Action No. 04-886(HAA), Ortho-McNeil Pharmaceutical, Inc., v. Teva Pharmaceutical Industries Ltd., and Teva Pharmaceuticals USA, Inc., Declaration of William L. Warren in Support of Defendants' Motion for Summary Judgment (Jan. 18, 2005). |
In the United States District Court for the District of New Jersey, Civil Action No. 04-886(HAA), Ortho-McNeil Pharmaceutical, Inc., v. Teva Pharmaceutical Industries Ltd., and Teva Pharmaceuticals USA, Inc., Deposition of Paul Short (Nov. 22 2004). |
In the United States District Court for the District of New Jersey, Civil Action No. 04-886(HAA), Ortho-McNeil Pharmaceutical, Inc., v. Teva Pharmaceutical Industries Ltd., and Teva Pharmaceuticals USA, Inc., Deposition of Robert W. Croce (Nov. 22, 2004). |
In the United States District Court for the District of New Jersey, Civil Action No. 04-886(HAA), Ortho-McNeil Pharmaceutical, Inc., v. Teva Pharmaceutical Industries Ltd., and Teva Pharmaceuticals USA, Inc., Expert Report of David Schoenfeld, Ph.D. (Mar. 31, 2005). |
In the United States District Court for the District of New Jersey, Civil Action No. 04-886(HAA), Ortho-McNeil Pharmaceutical, Inc., v. Teva Pharmaceutical Industries Ltd., and Teva Pharmaceuticals USA, Inc., Expert Report of Donald R. Stanski, M.D.(Jan. 14, 2005), [Redacted]. |
In the United States District Court for the District of New Jersey, Civil Action No. 04-886(HAA), Ortho-McNeil Pharmaceutical, Inc., v. Teva Pharmaceutical Industries Ltd., and Teva Pharmaceuticals USA, Inc., Expert Report of Eric Smith, Ph.D. (Jan. 14, 2005). |
In the United States District Court for the District of New Jersey, Civil Action No. 04-886(HAA), Ortho-McNeil Pharmaceutical, Inc., v. Teva Pharmaceutical Industries Ltd., and Teva Pharmaceuticals USA, Inc., Expert Report of Gilbert J. Fanciullo, M.D., (Mar. 17, 2005). |
In the United States District Court for the District of New Jersey, Civil Action No. 04-886(HAA), Ortho-McNeil Pharmaceutical, Inc., v. Teva Pharmaceutical Industries Ltd., and Teva Pharmaceuticals USA, Inc., Plaintiff's Brief in Opposition to Teva's Motion for Summary Judgment of Invalidity and Noninfringement of U.S. Pat. No. 5,336,691: Claim 6 (Feb. 17, 2005) [Redacted]. |
In the United States District Court for the District of New Jersey, Civil Action No. 04-886(HAA), Ortho-McNeil Pharmaceutical, Inc., v. Teva Pharmaceutical Industries Ltd., and Teva Pharmaceuticals USA, Inc., Plaintiff's Rule 56.1 Statement of Disputed Material Facts in Opposition to Defendants Teva Ltc. And Teva USA's Motion for Summary Judgment of Invalidity and Noninfringement of U.S. Pat. No. 5,336,691: Claim 6 Feb. 17, 2005. |
In the United States District Court for the District of New Jersey, Civil Action No. 04-886(HAA), Ortho-McNeil Pharmaceutical, Inc., v. Teva Pharmaceutical Industries Ltd., and Teva Pharmaceuticals USA, Inc., Reply Brief in Further Support of Defendants' Motion for Summary Judgment of Invalidity and Noninfringement of U.S. Pat. No. 5,336,691 Claim 6, Mar. 15, 2005 (Redacted). |
In the United States District Court for the District of New Jersey, Civil Action No. 04-886(HAA), Ortho-McNeil Pharmaceutical, Inc., v. Teva Pharmaceutical Industries Ltd., and Teva Pharmaceuticals USA, Inc., Teva Pharmaceuticals USA, Inc.'s Responses and Objections to Plaintiff Ortho-McNeil Pharmaceutical, Inc.'s First Set of Interrogatories [Redacted]. |
In the United States District Court for the District of New Jersey, Civil Action No. 04-886(HAA), Ortho-McNeil Pharmaceutical, Inc., v. Teva Pharmaceutical Industries Ltd., and Teva Pharmaceuticals USA, Inc., Teva Pharmaceuticals USA, Inc.'s Supplemental Responses and Objections to Plaintiff Ortho-McNeil Pharmaceutical, Inc.'s First Set of Interrogatories, Dec. 10, 2004. |
In the United States District Court for the District of New Jersey, Civil Action No. 04-886(HAA), Ortho-McNeil Pharmaceutical, Inc., v. Teva Pharmaceutical Industries Ltd., and Teva Pharmaceuticals USA, Inc., Teva Pharmaceuticals USA, Inc.'s Supplemental Responses and Objections to Plaintiff Ortho-McNeil Pharmaceutical, Inc.'s First Set of Interrogatories, Nov. 29, 2004. |
In the United States District Court for the District of New Jersey, Civil Action No. 04-886(HAA), Ortho-McNeil Pharmaceutical, Inc., v. Teva Pharmaceutical Industries Ltd., and Teva Pharmaceuticals, USA, Inc., Complaint, (Feb. 25, 2004). |
In the United States District Court for the District of New Jersey, Civil Action No. 04-886(HAA), Ortho-McNeil Pharmaceutical, Inc., v. Teva Pharmaceutical Industries Ltd., Deposition of Donald Stanski, M.D., May 27, 2005 (REDACTED). |
In the United States District Court for the District of New Jersey, Civil Action No. 04-886(HAA), Ortho-McNeil Pharmaceutical, Inc., v. Teva Pharmaceutical Industries Ltd., Deposition of Dr. David Schoenfeld, May 17, 2005. |
In the United States District Court for the District of New Jersey, Civil Action No. 04-886(HAA), Ortho-McNeil Pharmaceutical, Inc., v. Teva Pharmaceutical Industries Ltd., Deposition of Dr. Gilbert Fanciullo, Jun. 14, 2005. |
In the United States District Court for the District of New Jersey, Civil Action No. 04-886(HAA), Ortho-McNeil Pharmaceutical, Inc., v. Teva Pharmaceutical Industries Ltd., Videotape Deposition of Eric Smith, Ph.D., May 13, 2005. |
In the United States District Court for the District of New Jersey, Civil Action No. 04-886(HAA), Teva Pharmaceutical Industries LTD.'s Answer, Affirmative Defenses, Counterclaims and Demand for Jury Trail (Mar. 19, 2004), Teva Pharmaceuticals USA, Inc.'s Answer, Affirmative Defenses, and Counterclaims. |
In the United States District Court for the District of New Jersey, Civil Action No:. 04-886(HAA), Teva Pharmaceutical Industries Ltd.'s Amended Answer, Affirmative Defenses, Counterclaims and Demand for Jury Trial (Oct. 26, 2004), Teva Pharmaceutical USA, Inc.'s Amended Answer, Affirmative Defenses, Counterclaims and Demand for Jury Trial (Oct. 26, 2004). |
In the United States District Court for the Eastern District of Michigan, Civil Action No. 2:04CV73698, Ortho-McNeil Pharmaceutical, Inc., v. Caraco Pharmaceutical Laboratories, Ltd., Caraco's Motion for Summary Judgment of Non-Infringement, Aug. 5, 2005, REDACTED. |
In the United States District Court for the Eastern District of Michigan, Civil Action No. 2:04CV73698, Ortho-McNeil Pharmaceutical, Inc., v. Caraco Pharmaceutical Laboratories, Ltd., Caraco's Second Supplemental Response to Plaintiff's First Set of Interrogatories, Jun. 24, 2005. |
In the United States District Court for the Eastern District of Michigan, Civil Action No. 2:04CV73698, Ortho-McNeil Pharmaceutical, Inc., v. Caraco Pharmaceutical Laboratories, Ltd., Caraco's Supplemental Response to Plaintiff's First Set of Interrogatories, Jun. 14, 2005, REDACTED. |
In the United States District Court for the Eastern District of Michigan, Civil Action No. 2:04CV73698, Ortho-McNeil Pharmaceutical, Inc., v. Caraco Pharmaceutical Laboratories, Ltd., Expert Report of Donald R. Stanski, M.D. Aug. 5, 2005, REDACTED. |
In the United States District Court for the Eastern District of Michigan, Civil Action No. 2:04CV73698, Ortho-McNeil Pharmaceutical, Inc., v. Caraco Pharmaceutical Laboratories, Ltd., Expert Report of Eric P. Smith, Ph.D., Aug. 8, 2005. |
In the United States District Court for the Eastern District of Michigan, Civil Action No. 2:04CV73698, Ortho-McNeil Pharmaceutical, Inc., v. Caraco Pharmaceutical Laboratories, Ltd., Ortho-McNeil's Opposition to Caraco's Motion for Summary Judgment of Non-Infringement, Aug. 29, 2005, REDACTED. |
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NL300152I2 (en) | 2006-05-01 |
DK0566709T5 (en) | 2009-05-18 |
DE69226624D1 (en) | 1998-09-17 |
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JP3381190B2 (en) | 2003-02-24 |
EP0566709B3 (en) | 2009-04-08 |
DE122004000032I1 (en) | 2005-11-24 |
AU2579992A (en) | 1993-04-05 |
CA2095523A1 (en) | 1993-03-07 |
DE122004000032I2 (en) | 2006-02-09 |
NL300152I1 (en) | 2004-08-02 |
LU91079I2 (en) | 2004-07-26 |
WO1993004675A1 (en) | 1993-03-18 |
CN1086133A (en) | 1994-05-04 |
DE69226624T3 (en) | 2009-11-05 |
KR100243956B1 (en) | 2000-03-02 |
CA2095523C (en) | 2004-06-22 |
SG80535A1 (en) | 2001-05-22 |
EP0566709A1 (en) | 1993-10-27 |
JPH06502869A (en) | 1994-03-31 |
ES2120451T7 (en) | 2009-11-05 |
HUT64838A (en) | 1994-03-28 |
CN1071571C (en) | 2001-09-26 |
DE69226624T2 (en) | 1999-03-04 |
HU9301313D0 (en) | 1993-09-28 |
EP0566709A4 (en) | 1994-04-06 |
HU219332B (en) | 2001-03-28 |
AU651247B2 (en) | 1994-07-14 |
RU2121346C1 (en) | 1998-11-10 |
US5336691A (en) | 1994-08-09 |
ES2120451T3 (en) | 1998-11-01 |
EP0566709B1 (en) | 1998-08-12 |
DK0566709T3 (en) | 1999-05-10 |
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