USRE43580E1 - Nasal calcitonin formulations - Google Patents
Nasal calcitonin formulations Download PDFInfo
- Publication number
- USRE43580E1 USRE43580E1 US12/459,385 US45938509A USRE43580E US RE43580 E1 USRE43580 E1 US RE43580E1 US 45938509 A US45938509 A US 45938509A US RE43580 E USRE43580 E US RE43580E
- Authority
- US
- United States
- Prior art keywords
- calcitonin
- pharmaceutical composition
- composition
- liquid pharmaceutical
- citric acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
Abstract
Description
TABLE 1 |
EFFECT OF THE CONCENTRATION OF CITRIC ACID |
ON THE BIOAVAILABILITY AND PLASMA |
CONCENTRATION OF SALMON CALCITONIN |
ADMINISTERED INTRANASALLY TO RATS |
Citric acid | Bioavailability | Maximum plasma sCT |
(pH 3.7) | (percent ± sdev) | (ng/ml ± sdev) |
0 | 0.89 ± 0.19 | 1.10 ± 0.52 |
10 | 3.14 ± 1.77 | 3.66 ± 1.67 |
25 | 5.01 ± 2.34 | 5.11 ± 2.09 |
50 | 6.15 ± 1.31 | 6.05 ± 1.30 |
100 | 13.36 ± 3.38 | 12.98 ± 3.96 |
TABLE 2 |
EFFECT OF PRESERVATIVES ON THE |
AVAILABILITY AND PLASMA CONCENTRATION |
OF SCT ADMINISTERED INTRANASALLY TO RATS |
Bioavailability | Maximum plasma sCT | |
Preservatives | (percent ± sdev) | (ng/m1 ± sdev) |
None | 1.14 ± 0.87 | 1.24 ± 0.79 |
0.2% phenylethyl alcohol - | 0.89 ± 0.19 | 1.10 ± 0.52 |
0.5% benzyl alcohol | ||
0.27 methyl parabens - | 1.08 ± 0.86 | 1.47 ± 1.46 |
0.04% propyl parabens | ||
TABLE 3 |
EFFECT OF THE CONCENTRATION OF |
CITRIC ACID ON THE STABILITY OF |
sCT STORED FOR VARYING PERIODS AT 50° C. |
Percent sCT Recovered |
Citric Acid | |||||||
(pH 3.7) | 0 mM | 10 mM | 20 mM | 50 mM | 100 mM | ||
Days at | |||||||
50° C. | |||||||
0 | 100 | 100 | 100 | 100 | 100 | ||
3 | 83 | 94 | 91 | 90 | 87 | ||
6 | 53 | 90 | 87 | 83 | 77 | ||
9 | 24 | 82 | 78 | 73 | 66 | ||
15 | 22 | 74 | 68 | 61 | 20 | ||
Claims (36)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/459,385 USRE43580E1 (en) | 2000-02-04 | 2009-06-29 | Nasal calcitonin formulations |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18024100P | 2000-02-04 | 2000-02-04 | |
US09/776,537 US6440392B1 (en) | 2000-02-04 | 2001-02-02 | Nasal calcitonin formulations |
US10/774,358 USRE40812E1 (en) | 2000-02-04 | 2004-02-05 | Nasal calcitonin formulation |
US12/459,385 USRE43580E1 (en) | 2000-02-04 | 2009-06-29 | Nasal calcitonin formulations |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/776,537 Reissue US6440392B1 (en) | 2000-02-04 | 2001-02-02 | Nasal calcitonin formulations |
Publications (1)
Publication Number | Publication Date |
---|---|
USRE43580E1 true USRE43580E1 (en) | 2012-08-14 |
Family
ID=22659737
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/776,537 Ceased US6440392B1 (en) | 2000-02-04 | 2001-02-02 | Nasal calcitonin formulations |
US10/774,358 Expired - Lifetime USRE40812E1 (en) | 2000-02-04 | 2004-02-05 | Nasal calcitonin formulation |
US12/459,385 Expired - Lifetime USRE43580E1 (en) | 2000-02-04 | 2009-06-29 | Nasal calcitonin formulations |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/776,537 Ceased US6440392B1 (en) | 2000-02-04 | 2001-02-02 | Nasal calcitonin formulations |
US10/774,358 Expired - Lifetime USRE40812E1 (en) | 2000-02-04 | 2004-02-05 | Nasal calcitonin formulation |
Country Status (6)
Country | Link |
---|---|
US (3) | US6440392B1 (en) |
EP (1) | EP1251867A4 (en) |
CN (1) | CN1183965C (en) |
AU (1) | AU783952B2 (en) |
CA (1) | CA2399505C (en) |
WO (1) | WO2001056594A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9399017B2 (en) | 2007-05-29 | 2016-07-26 | Enteris Biopharma, Inc. | Peptide pharmaceutical for oral delivery |
US9457086B2 (en) | 2013-03-05 | 2016-10-04 | Enteris Biopharma, Inc. | Pharmaceuticals for oral delivery |
US9833411B2 (en) | 2015-01-12 | 2017-12-05 | Enteris Biopharma, Inc. | Solid oral dosage forms |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1251867A4 (en) | 2000-02-04 | 2004-12-08 | Unigene Lab Inc | Nasal calcitonin formulations |
US20090035260A1 (en) * | 2002-07-29 | 2009-02-05 | Therapicon Srl | Enhanced nasal composition of active peptide |
US8008255B2 (en) | 2003-05-30 | 2011-08-30 | Amylin Pharmaceuticals, Inc. | Methods and compositions for enhanced transmucosal delivery of peptides and proteins |
CN1546169A (en) * | 2003-12-16 | 2004-11-17 | 上海医药工业研究院 | Transnasal inhalant dry powder of calcitonin and its preparation |
ITMI20040235A1 (en) * | 2004-02-13 | 2004-05-13 | Therapicon Srl | PHARMACEUTICAL PREPARATION FOR THE ORAL CABLE |
US20090069226A1 (en) * | 2004-05-28 | 2009-03-12 | Amylin Pharmaceuticals, Inc. | Transmucosal delivery of peptides and proteins |
CN101549149B (en) * | 2008-09-17 | 2011-12-28 | 北京双鹭药业股份有限公司 | New nasal spray formulation of calcitonin aqueous solution |
US20100256060A1 (en) * | 2009-04-02 | 2010-10-07 | Unigene Laboratories Inc. | Peptide pharmaceuticals for nasal delivery |
CN108969754B (en) * | 2018-09-04 | 2019-06-21 | 深圳大佛药业股份有限公司 | A kind of Salmon Calcitonin Nasal Spray and preparation method thereof |
Citations (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4151276A (en) | 1975-05-12 | 1979-04-24 | Armour Pharmaceutical Company | Method of suppressing gastric acid secretion by the oral administration of calcitonin |
GB2092002A (en) | 1981-01-14 | 1982-08-11 | Toyo Jozo Kk | Suppositories, injectable solutions |
EP0115627A1 (en) | 1982-12-29 | 1984-08-15 | Armour Pharmaceutical Company | Enhancement of intranasal absorption of calcitonin by formulation with surfactants |
US4476116A (en) | 1982-12-10 | 1984-10-09 | Syntex (U.S.A.) Inc. | Polypeptides/chelating agent nasal compositions having enhanced peptide absorption |
US4609640A (en) | 1981-11-17 | 1986-09-02 | Toyo Jozo Company, Ltd. | Preparation having excellent absorption property |
US4690952A (en) | 1984-11-26 | 1987-09-01 | Yamanouchi Pharmaceutical Co., Inc. | Pharmaceutical compositions for nasal administration comprising calcitonin and an absorption-promoting substance |
US4845080A (en) | 1983-06-27 | 1989-07-04 | Ciba-Geigy Corporation | Human calcitonin peptide with salmon calcitonin-like characteristics |
EP0327756A2 (en) | 1987-11-13 | 1989-08-16 | Smithkline Beecham Farmaceutici S.p.A. | Pharmaceutical compositions comprising a calcitonin and a glycyrrhizinate as absorption enhancer |
US4900730A (en) | 1981-01-14 | 1990-02-13 | Toyo Jozo Co., Ltd. | Preparation which promotes the absorption of peptides |
EP0358234A2 (en) | 1988-09-08 | 1990-03-14 | Rhone-Poulenc Rorer International (Holdings) Inc. | Intranasal calcitonin formulations |
EP0418697A1 (en) * | 1989-09-15 | 1991-03-27 | ESSETI s.a.s. LABORATORIO CHIMICO FARMACO BIOLOGICO DI A. IEVOLI & C. | Pharmaceutical compositions containing calcitonin |
US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
US5059587A (en) | 1987-08-03 | 1991-10-22 | Toyo Jozo Company, Ltd. | Physiologically active peptide composition for nasal administration |
EP0489217A1 (en) | 1990-12-05 | 1992-06-10 | Dr. A. Tosi Farmaceutici S.R.L. | Calcitonin compositions for intranasal administration |
US5124315A (en) | 1989-11-16 | 1992-06-23 | Phideatech S.R.L. | Liquid pharmaceutical composition for nasal administration containing a polypeptide as active ingredient |
US5169849A (en) | 1982-02-01 | 1992-12-08 | Sandoz Ltd. | Nasal pharmaceutical compositions |
JPH0578258A (en) | 1991-09-20 | 1993-03-30 | Suntory Ltd | Stable calcitonin medicinal composition and its production |
US5234906A (en) | 1991-01-10 | 1993-08-10 | Amylin Pharmaceuticals, Inc. | Hyperglycemic compositions |
US5279836A (en) | 1991-02-19 | 1994-01-18 | Mediator S.R.L. | Topical use of calcitonin for the preparation of medications in senile idiopathic cataract and a pharmaeutical composition thereof |
US5281580A (en) | 1990-08-16 | 1994-01-25 | Toyo Jozo Company, Ltd. | Calcitonin-containing emulsion for nasal administration |
US5310727A (en) | 1986-06-20 | 1994-05-10 | Scalvo S.P.A. | Pharmaceutical compositions for parenteral use containing a calcitonin as the active ingredient |
US5496801A (en) | 1993-12-23 | 1996-03-05 | Allelix Biopharmaceuticals Inc. | Parathyroid hormone formulation |
US5514365A (en) | 1988-10-11 | 1996-05-07 | Schiapparelli Salute S.P.A. | Pharmaceutical compositions comprising calcitonin for intranasal administration |
US5534496A (en) | 1992-07-07 | 1996-07-09 | University Of Southern California | Methods and compositions to enhance epithelial drug transport |
US5536508A (en) | 1990-11-22 | 1996-07-16 | Vectorpharma International S.P.A. | Pharmaceutical compositions in the form of particles suitable for the controlled release of pharmacologically active substances and process for preparing the same compositions |
EP0726075A1 (en) | 1995-02-08 | 1996-08-14 | Therapicon Srl | Pharmaceutical non-inorganic saline solutions for endonasal administration |
US5571788A (en) | 1991-12-09 | 1996-11-05 | Ciba-Geigy Corporation | Stable calcitonin pharmaceutical compositions |
US5593962A (en) | 1991-04-23 | 1997-01-14 | Ciba-Geigy Corporation | Fibrillated calcitonin pharmaceutical compositions |
US5637309A (en) | 1993-09-20 | 1997-06-10 | Shiseido Company, Ltd. | Physiologically active substance-prolonged releasing-type pharmaceutical preparation |
US5654000A (en) | 1992-07-28 | 1997-08-05 | Poli Industria Chimica S.P.A. | Pharmaceutical compositions for transmucosal delivery of peptides |
US5665700A (en) | 1990-03-29 | 1997-09-09 | Skua Investments Limited | Pharmaceutical formulations |
US5693608A (en) | 1990-05-10 | 1997-12-02 | Bechgaard International Research And Development A/S | Method of administering a biologically active substance |
US5714477A (en) | 1993-06-18 | 1998-02-03 | Pharmacia & Upjohn Aktiebolag | Pharmaceutical composition containing heparin, heparin fragments or their derivatives in combination with glycerol esters |
US5719122A (en) * | 1992-10-20 | 1998-02-17 | Smithkline Beecham Farmaceutici S.P.A. | Pharmaceutical compositions containing a calcitonin |
US5726154A (en) | 1996-06-28 | 1998-03-10 | University Of Utah Research Foundation | Stabilization and oral delivery of calcitonin |
US5725871A (en) | 1989-08-18 | 1998-03-10 | Danbiosyst Uk Limited | Drug delivery compositions comprising lysophosphoglycerolipid |
US5733569A (en) | 1982-10-05 | 1998-03-31 | Novartis Corporation | Galenic compositions comprising calcitonin and their use |
US5733572A (en) | 1989-12-22 | 1998-03-31 | Imarx Pharmaceutical Corp. | Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles |
US5759566A (en) | 1992-07-28 | 1998-06-02 | Poli Industria Chimica Spa | Microemulsion pharmaceutical compositions for the delivery of pharmaceutically active agents |
US5776886A (en) | 1993-06-07 | 1998-07-07 | Teikoku Seiyaku Kabushiki Kaisha | Intravaginal preparation containing physiologically active peptide |
US5858391A (en) | 1994-06-20 | 1999-01-12 | Kv Pharmaceutical Company | Long acting GI and esophageal protectant |
US5912014A (en) | 1996-03-15 | 1999-06-15 | Unigene Laboratories, Inc. | Oral salmon calcitonin pharmaceutical products |
US5938654A (en) | 1987-06-25 | 1999-08-17 | Alza Corporation | Osmotic device for delayed delivery of agent |
US5968899A (en) | 1994-06-03 | 1999-10-19 | Tsumura & Co. | Medicinal compositions of peptides with EACA or tranexamic acid for enhanced mucosal absorption |
US6017538A (en) | 1992-10-19 | 2000-01-25 | Institut Pasteur | Plasmodium falciparum antigens inducing protective antibodies |
US6149893A (en) | 1999-03-01 | 2000-11-21 | Alfa Wassermann S.P.A. | Pharmaceutical compositions containing calcitonin in a spray dosing feeder for intranasal administration |
US6153582A (en) | 1998-11-05 | 2000-11-28 | Bausch & Lomb Surgical, Inc. | Defined serumfree medical solution for ophthalmology |
US6348207B1 (en) | 1992-06-15 | 2002-02-19 | Emisiphere Technologies, Inc. | Orally deliverable supramolecular complex |
US6440446B1 (en) | 1998-04-22 | 2002-08-27 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Agent for anti-osteoporosis |
US6440392B1 (en) | 2000-02-04 | 2002-08-27 | Unigene Laboratories, Inc. | Nasal calcitonin formulations |
US6447785B1 (en) | 2000-02-15 | 2002-09-10 | Allergan Sales, Inc. | Method for treating hypercalcemia |
US6509006B1 (en) | 1992-07-08 | 2003-01-21 | Inhale Therapeutic Systems, Inc. | Devices compositions and methods for the pulmonary delivery of aerosolized medicaments |
-
2001
- 2001-01-31 EP EP01908769A patent/EP1251867A4/en not_active Withdrawn
- 2001-01-31 AU AU36604/01A patent/AU783952B2/en not_active Ceased
- 2001-01-31 CA CA2399505A patent/CA2399505C/en not_active Expired - Fee Related
- 2001-01-31 CN CNB01807605XA patent/CN1183965C/en not_active Expired - Fee Related
- 2001-01-31 WO PCT/US2001/003212 patent/WO2001056594A1/en active IP Right Grant
- 2001-02-02 US US09/776,537 patent/US6440392B1/en not_active Ceased
-
2004
- 2004-02-05 US US10/774,358 patent/USRE40812E1/en not_active Expired - Lifetime
-
2009
- 2009-06-29 US US12/459,385 patent/USRE43580E1/en not_active Expired - Lifetime
Patent Citations (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4151276A (en) | 1975-05-12 | 1979-04-24 | Armour Pharmaceutical Company | Method of suppressing gastric acid secretion by the oral administration of calcitonin |
GB2092002A (en) | 1981-01-14 | 1982-08-11 | Toyo Jozo Kk | Suppositories, injectable solutions |
US4900730A (en) | 1981-01-14 | 1990-02-13 | Toyo Jozo Co., Ltd. | Preparation which promotes the absorption of peptides |
US4609640A (en) | 1981-11-17 | 1986-09-02 | Toyo Jozo Company, Ltd. | Preparation having excellent absorption property |
US5169849A (en) | 1982-02-01 | 1992-12-08 | Sandoz Ltd. | Nasal pharmaceutical compositions |
US5733569A (en) | 1982-10-05 | 1998-03-31 | Novartis Corporation | Galenic compositions comprising calcitonin and their use |
US5759565A (en) * | 1982-10-05 | 1998-06-02 | Novartis Corporation | Galenic compositions comprising calcitonin and their use |
US4476116A (en) | 1982-12-10 | 1984-10-09 | Syntex (U.S.A.) Inc. | Polypeptides/chelating agent nasal compositions having enhanced peptide absorption |
EP0115627A1 (en) | 1982-12-29 | 1984-08-15 | Armour Pharmaceutical Company | Enhancement of intranasal absorption of calcitonin by formulation with surfactants |
US4845080A (en) | 1983-06-27 | 1989-07-04 | Ciba-Geigy Corporation | Human calcitonin peptide with salmon calcitonin-like characteristics |
US4690952A (en) | 1984-11-26 | 1987-09-01 | Yamanouchi Pharmaceutical Co., Inc. | Pharmaceutical compositions for nasal administration comprising calcitonin and an absorption-promoting substance |
US4788221A (en) | 1984-11-26 | 1988-11-29 | Yamanouchi Pharmaceutical Co., Ltd. | Pharmaceutical compositions comprising calcitonin and an absorption-promoting substance |
EP0371010A1 (en) | 1984-11-26 | 1990-05-30 | Yamanouchi Pharmaceutical Co. Ltd. | Absorbable calcitonin medicament |
US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
US5310727A (en) | 1986-06-20 | 1994-05-10 | Scalvo S.P.A. | Pharmaceutical compositions for parenteral use containing a calcitonin as the active ingredient |
US5938654A (en) | 1987-06-25 | 1999-08-17 | Alza Corporation | Osmotic device for delayed delivery of agent |
US5059587A (en) | 1987-08-03 | 1991-10-22 | Toyo Jozo Company, Ltd. | Physiologically active peptide composition for nasal administration |
EP0327756A2 (en) | 1987-11-13 | 1989-08-16 | Smithkline Beecham Farmaceutici S.p.A. | Pharmaceutical compositions comprising a calcitonin and a glycyrrhizinate as absorption enhancer |
US5183802A (en) | 1987-11-13 | 1993-02-02 | Isf Societa Per Azioni | Pharmaceutical compositions for intranasal administration of calcitonin |
US5026825A (en) * | 1988-09-08 | 1991-06-25 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Intranasal calcitonin formulations |
EP0358234A2 (en) | 1988-09-08 | 1990-03-14 | Rhone-Poulenc Rorer International (Holdings) Inc. | Intranasal calcitonin formulations |
US5514365A (en) | 1988-10-11 | 1996-05-07 | Schiapparelli Salute S.P.A. | Pharmaceutical compositions comprising calcitonin for intranasal administration |
US5725871A (en) | 1989-08-18 | 1998-03-10 | Danbiosyst Uk Limited | Drug delivery compositions comprising lysophosphoglycerolipid |
EP0418697A1 (en) * | 1989-09-15 | 1991-03-27 | ESSETI s.a.s. LABORATORIO CHIMICO FARMACO BIOLOGICO DI A. IEVOLI & C. | Pharmaceutical compositions containing calcitonin |
US5124315A (en) | 1989-11-16 | 1992-06-23 | Phideatech S.R.L. | Liquid pharmaceutical composition for nasal administration containing a polypeptide as active ingredient |
US5733572A (en) | 1989-12-22 | 1998-03-31 | Imarx Pharmaceutical Corp. | Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles |
US5665700A (en) | 1990-03-29 | 1997-09-09 | Skua Investments Limited | Pharmaceutical formulations |
US5693608A (en) | 1990-05-10 | 1997-12-02 | Bechgaard International Research And Development A/S | Method of administering a biologically active substance |
US5281580A (en) | 1990-08-16 | 1994-01-25 | Toyo Jozo Company, Ltd. | Calcitonin-containing emulsion for nasal administration |
US5536508A (en) | 1990-11-22 | 1996-07-16 | Vectorpharma International S.P.A. | Pharmaceutical compositions in the form of particles suitable for the controlled release of pharmacologically active substances and process for preparing the same compositions |
US5700486A (en) | 1990-11-22 | 1997-12-23 | Vectorpharma International S.P.A. | Pharmaceutical compositions in the form of particles suitable for the controlled release of pharmacologically active substances and process for preparing the same compositions |
EP0489217A1 (en) | 1990-12-05 | 1992-06-10 | Dr. A. Tosi Farmaceutici S.R.L. | Calcitonin compositions for intranasal administration |
US5234906A (en) | 1991-01-10 | 1993-08-10 | Amylin Pharmaceuticals, Inc. | Hyperglycemic compositions |
US5279836A (en) | 1991-02-19 | 1994-01-18 | Mediator S.R.L. | Topical use of calcitonin for the preparation of medications in senile idiopathic cataract and a pharmaeutical composition thereof |
US5593962A (en) | 1991-04-23 | 1997-01-14 | Ciba-Geigy Corporation | Fibrillated calcitonin pharmaceutical compositions |
JPH0578258A (en) | 1991-09-20 | 1993-03-30 | Suntory Ltd | Stable calcitonin medicinal composition and its production |
US5571788A (en) | 1991-12-09 | 1996-11-05 | Ciba-Geigy Corporation | Stable calcitonin pharmaceutical compositions |
US6348207B1 (en) | 1992-06-15 | 2002-02-19 | Emisiphere Technologies, Inc. | Orally deliverable supramolecular complex |
US5534496A (en) | 1992-07-07 | 1996-07-09 | University Of Southern California | Methods and compositions to enhance epithelial drug transport |
US6509006B1 (en) | 1992-07-08 | 2003-01-21 | Inhale Therapeutic Systems, Inc. | Devices compositions and methods for the pulmonary delivery of aerosolized medicaments |
US5654000A (en) | 1992-07-28 | 1997-08-05 | Poli Industria Chimica S.P.A. | Pharmaceutical compositions for transmucosal delivery of peptides |
US5759566A (en) | 1992-07-28 | 1998-06-02 | Poli Industria Chimica Spa | Microemulsion pharmaceutical compositions for the delivery of pharmaceutically active agents |
US6017538A (en) | 1992-10-19 | 2000-01-25 | Institut Pasteur | Plasmodium falciparum antigens inducing protective antibodies |
US5719122A (en) * | 1992-10-20 | 1998-02-17 | Smithkline Beecham Farmaceutici S.P.A. | Pharmaceutical compositions containing a calcitonin |
US6008189A (en) | 1993-06-07 | 1999-12-28 | Teikoku Seiyaku Kabushiki Kaisha | Intravaginal preparation containing physiologically active peptide |
US5776886A (en) | 1993-06-07 | 1998-07-07 | Teikoku Seiyaku Kabushiki Kaisha | Intravaginal preparation containing physiologically active peptide |
US5714477A (en) | 1993-06-18 | 1998-02-03 | Pharmacia & Upjohn Aktiebolag | Pharmaceutical composition containing heparin, heparin fragments or their derivatives in combination with glycerol esters |
US5637309A (en) | 1993-09-20 | 1997-06-10 | Shiseido Company, Ltd. | Physiologically active substance-prolonged releasing-type pharmaceutical preparation |
US5496801A (en) | 1993-12-23 | 1996-03-05 | Allelix Biopharmaceuticals Inc. | Parathyroid hormone formulation |
US5968899A (en) | 1994-06-03 | 1999-10-19 | Tsumura & Co. | Medicinal compositions of peptides with EACA or tranexamic acid for enhanced mucosal absorption |
US5858391A (en) | 1994-06-20 | 1999-01-12 | Kv Pharmaceutical Company | Long acting GI and esophageal protectant |
US6087338A (en) * | 1995-02-08 | 2000-07-11 | Therapicon S.R.L. | Pharmaceutical non inorganic saline solutions for endonasal administration of a calcitonin |
EP0809512A1 (en) | 1995-02-08 | 1997-12-03 | Therapicon Srl | Pharmaceutical non inorganic saline solutions for endonasal administration of a calcitonin |
US6107277A (en) | 1995-02-08 | 2000-08-22 | Therapicon S.R.L. | Calcitonin salmon analogues |
EP0726075A1 (en) | 1995-02-08 | 1996-08-14 | Therapicon Srl | Pharmaceutical non-inorganic saline solutions for endonasal administration |
US6086918A (en) | 1996-03-15 | 2000-07-11 | Unigene Laboratories, Inc. | Oral peptide pharmaceutical products |
US5912014A (en) | 1996-03-15 | 1999-06-15 | Unigene Laboratories, Inc. | Oral salmon calcitonin pharmaceutical products |
US5726154A (en) | 1996-06-28 | 1998-03-10 | University Of Utah Research Foundation | Stabilization and oral delivery of calcitonin |
US6440446B1 (en) | 1998-04-22 | 2002-08-27 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Agent for anti-osteoporosis |
US6153582A (en) | 1998-11-05 | 2000-11-28 | Bausch & Lomb Surgical, Inc. | Defined serumfree medical solution for ophthalmology |
US6149893A (en) | 1999-03-01 | 2000-11-21 | Alfa Wassermann S.P.A. | Pharmaceutical compositions containing calcitonin in a spray dosing feeder for intranasal administration |
US6440392B1 (en) | 2000-02-04 | 2002-08-27 | Unigene Laboratories, Inc. | Nasal calcitonin formulations |
USRE40812E1 (en) * | 2000-02-04 | 2009-06-30 | Unigene Laboratories Inc. | Nasal calcitonin formulation |
US6447785B1 (en) | 2000-02-15 | 2002-09-10 | Allergan Sales, Inc. | Method for treating hypercalcemia |
Non-Patent Citations (106)
Title |
---|
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Also Published As
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WO2001056594A1 (en) | 2001-08-09 |
AU3660401A (en) | 2001-08-14 |
CN1422160A (en) | 2003-06-04 |
CN1183965C (en) | 2005-01-12 |
EP1251867A4 (en) | 2004-12-08 |
USRE40812E1 (en) | 2009-06-30 |
CA2399505A1 (en) | 2001-08-09 |
US6440392B1 (en) | 2002-08-27 |
AU783952B2 (en) | 2006-01-05 |
EP1251867A1 (en) | 2002-10-30 |
CA2399505C (en) | 2012-01-03 |
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