Búsqueda Imágenes Maps Play YouTube Noticias Gmail Drive Más »
Iniciar sesión
Usuarios de lectores de pantalla: deben hacer clic en este enlace para utilizar el modo de accesibilidad. Este modo tiene las mismas funciones esenciales pero funciona mejor con el lector.

Patentes

  1. Búsqueda avanzada de patentes
Número de publicaciónWO1986002275 A1
Tipo de publicaciónSolicitud
Número de solicitudPCT/SE1985/000385
Fecha de publicación24 Abr 1986
Fecha de presentación8 Oct 1985
Fecha de prioridad9 Oct 1984
También publicado comoDE8590143U1, EP0197113A1
Número de publicaciónPCT/1985/385, PCT/SE/1985/000385, PCT/SE/1985/00385, PCT/SE/85/000385, PCT/SE/85/00385, PCT/SE1985/000385, PCT/SE1985/00385, PCT/SE1985000385, PCT/SE198500385, PCT/SE85/000385, PCT/SE85/00385, PCT/SE85000385, PCT/SE8500385, WO 1986/002275 A1, WO 1986002275 A1, WO 1986002275A1, WO 8602275 A1, WO 8602275A1, WO-A1-1986002275, WO-A1-8602275, WO1986/002275A1, WO1986002275 A1, WO1986002275A1, WO8602275 A1, WO8602275A1
InventoresKarl Holm
SolicitanteAktiebolaget Draco
Exportar citaBiBTeX, EndNote, RefMan
Enlaces externos:  Patentscope, Espacenet
Medical spray device
WO 1986002275 A1
Resumen
An aerosol device comprising a pressurized aerosol container (4) having a dosing discharge valve (8) adapted to discharge a controlled quantity of fluid from the aerosol container (4) each time it is actuated. A counter (20) is arranged so as to be actuated by each actuation of the discharge valve (8), and said counter (20) being effective to give a visual indication when the container (4) is about to be exhausted.
Reclamaciones  (El texto procesado por OCR puede contener errores)
CL A I MS :
1. An aerosol device comprising or consisting of a non-transparent aerosol container having a dosage dis¬ charge valve adapted to discharge a controlled quantity of fluid from the container each time it is actuated, characterized in that the aerosol container is of the type containing a specified minimum number of doses and that the device comprises a counter arranged so as to be acti¬ vated by each actuation of the discharge valve, the counter being effective to give a visual indication when the container is about to have discharged the specified minimum of doses .
2. An aerosol device according to claim 1 and comprising a holder for the aerosol container, the holder having a re¬ cess for engaging a spring loaded discharge tube of the dosing discharge valve of the container and a spray or atomizing nozzle connected to said recess, whereby, when said container is pushed to be displaced inwardly in said holder the discharge tube is depressed towards the interior of the container to hereby actuate the dosing discharge valve, characterized in that the counter is arranged so as to be activated by each operative displacement of the container or by the pushing force applied to the container for effecting each operative displacement.
3. An aerosol device according to claim 2, character zed in that the counter comprises an actuation member located at the outside of the end portion of the container opposite to said discharge tube, said actuation member being operable to transfer an applied actuation pressure to said container end portion and to hereby also activate the counter.
4. An aerosol device according to claim 3, characterized in that the counter is a counter unit directly associated with said actuation member and placed between said end por¬ tion of the container and sa d actuation member.
5. An aerosol container for use in an aerosol device according to claim 4, provided at one end with a resiliently depressable discharge tube associated with a dosage dis¬ charge valve of or in the container, characterized in that at the opposite end of the container there is arranged a counter unit comprising an outermost actuation member for receiving an actuation pressure towards the container, said counter unit being designed so as to count and dis¬ play its counting for each consecutive application of an actuation pressure against the container.
6. An aerosol container according to claim 5 , charac¬ terized in that the the counter is a conventional multiple digital wheel counter and that the actuation member includes a transparent lens portion to enlarge the display of the counter.
7. An auxiliary unit for use on an end portion of an aerosol container according to claim 5, characterized in that it consists of a counter unit comprising a holding portion adapted to be fastenable to the base end portion of the container and an actuation cap operable to receive an actuation pressure towards said container base end por¬ tion so as to transfer the actuation pressure to the container and additionally count the associated consecutive actuations of the dosage discharge valve of the container.
8. An auxiliary unit according to claim 7, characterized in that the counter is a conventional multiple digital wheel counter, which is housed within a casing as constituted by said holding portion and sa d actuation cap portion, these portions being mutually displaceable to enable an activation of the counter.
Descripción  (El texto procesado por OCR puede contener errores)

MEDICAL SPRAY DEVICE

DESCRIPTION

The present invention relates to an aerosol device. Most forms of aerosol device comprise a metal container and a discharge valve through which the fluid within the container may be discharged via a nozzle. The discharge valve may give a continuous spray when they are actuated or they may give a dosed quantity. In either event, it is never clear to the user how much of the fluid remains within the container.

In many instances this will cause no real problems, but it can be very unsatisfactory when the aerosol device is used for dispensing doses of a medicament. One particular type of such aerosol device is in the form of a medical mouth or throat spray device, which includes a holder for an aerosol container designed so as to discharge a predetermined dose of a medicament each time the device is operated, the holder having a spray or atomizing nozzle through which doses are discharged. The aerosol container is provided with a depressable dosing valve having a discharge tube and is mounted or mountable in the holder with this discharge tube received in the recess connected to the atomizer nozzle. The container is inserted and held in an outwardly open guide portion of the holder, such that the container is pressed downwardly in the guide portion, e.g. by applying thumb pressure on the base of the container, so that the discharge nozzle is forced towards the interior of the container thereby discharging the dose of spray.

Devices of this type are used, for example, for dosed supply for the respiratory passages of patients having asthma or other respiratory diseases and they are used and operated by the patients themselves. For the patients, it is often of the utmost importance that they should always have to hand an operative spray device, i.e. they should know when to procure a new device, or at least a new pressurized container, before an existing container has been exhausted. These containers are usually metallic, to with¬ stand the pressure and are thus not transparent, so that the patient cannot directly see how much medicament is left in the container. Theoretically this may be ascer- tained by weighing the container or by a buoyancy test, whereby the container will float at a high level when it is about to be exhausted, but only relatively few patients are capable of carrying out such tests, e.g. determining whether a holiday period or even a weekend can be started without previously obtaining a new container.

According to US-A-3505870, it has already been proposed to provide an aerosol container with a transpa¬ rent window enabling the user to determine the remaining volume of liquid in the container, but this requires a highly undesirable modification of the container itself.

The invention more specifically relates to an aerosol device comprising or consisting of a non-transparent aero¬ sol container of the type operable to produce a predeter¬ mined dose by each actuation, and it is the purpose of the invention to provide an aerosol device of this type, which will enable the user to easily determine when the container is about to be exhausted.

The invention is based on the recognition that this purpose is achievable by automatic counting of the conse- cutive actuations, provided it is known beforehand how many doses the aerosol container can produce. Basically, therefore, the invention resides in the combination of selecting an aerosol container holding a known number of doses and providing for an- automatic counting of the actua- tions of the dosing discharge valve, such that the user may somehow, all according to the manner in which the coun¬ ting is effected, get warned when there is only a small number of doses left in the container.

However, in practice the invention is greatly assis- ted by an already established practice, according to which the aerosol containers of the relevant type are normally marked to hold a guaranteed number of doses, e.g. 200 or 400, and the capacity of a given aerosol container, there¬ fore, will easily be relatable to an automatic counting of the actual doses discharged, without the user having to know the exact number of doses actually present in the single container. The user may simply rely on the guaran¬ teed number and observe the counter having counted up or down to or from this number corresponding to a remaining small number of the number of guaranteed doses. Accordingly, based on this general concept, the in¬ vention is characterized by the features stated in the characterizing clause of claim 1.

It is readily admitted that it is well known in the art to automatically count the doses as discharged through dosing valve means of various containers and bottles, pri¬ marily liquor bottles, but it will be appreciated that this is done for positively counting the discharged doses and not at all for telling the user when the bottle is about to be empty. Such dose counters have been in exist- ence for many years without giving rise to any solution of the problem here in question.

The invention as specifically relating to non-trans¬ parent aerosol containers and to a warning of such a con¬ tainer being "almost exhausted" could well, thus, make use of some known dose counting system, e.g. including a direct operative connection between a discharge valve activating handle means and a counter unit, but the inven¬ tion is still more specifically built on the recognition that such a direct operative connection as established for each single aerosol container is avoidable due to the fact that the normal manner of actuating the discharge valve is to cause a displacement of the entire aerosol container relative the discharge tube thereof as held in said recess in a tube socket in the associated holder. In a highly preferred embodiment of the invention, therefore, the counter unit is arranged so as to be actua- ted by the very displacement of the aerosol container or - even preferably - by the force applied to the container for causing the actuation displacement thereof, whereby the single containers should not be provided with any spe- cial handle means for actuating the associated discharge valves. Thus, according to claim 2, the counter unit may be placed in connection with either the holder unit or the container so as to be operable by the displacement of the container or by the actuation pressing force on the container by each actuation thereof, without the dis¬ charge tube of the container having any kind of direct connection with the counter or with special actuator hand¬ le means.

The counter unit, therefore, may be arranged optional- ly in connection with the holder, so as to count each axial displacement of the container or each actuation pressure thereon as represented by the pressure of the discharge tube against said tube socket.

However, in a preferred embodiment of the invention the counting is effected based on the device normally being actuated by a finger pressure against the exposed bottom portion of the container, whereby the counter unit may comprise an actuation member located on the outside of the bottom portion of the container so as to be operable to effectively transfer an applied actuation pressure to said bottom portion and thereby even operate the counter unit.

Preferably, based on this concept, the actuation member is provided integrally with the counter unit, which, as a cap member, is mounted on the bottom end portion of the aerosol container. The counter unit as hereby being entirely separate from the holder will thus, on receiving an actuation pressure, both count the actuation and get displaced along with the container relative the holder. It will be appreciated that a container as provided with such a counter end cap member may constitute a refill unit to be placed in the holder upon the emptying of the preceding container. The invention, therefore, also com¬ prises such a refill container unit, which can be used without any kind of adaptation for the present purpose. The counter unit of the container unit may be preset in accordance with the guaranteed number of doses of the speci¬ fic container.

The counter unit or member as placed on the bottom end of the container may well be disintegral with the con- tainer or sold as a separate unit, e.g. even for use as an interchangeable end cap member on several consecutively used standard containers, and the invention, therefore, even comprises such a separate counter unit.

The counter unit, generally, may operate according to any suitable principle, e.g. so as to just cause a vis¬ ible signal to be produced when the container is about to be exhausted. Preferably, however, the counter should be an ordinary digital counter steadily displaying its respective counter stages, whereby the counter will enable the patient to follow and control his treatment, inasfar as the counter will make it possible to register the number of doses which the patient inhales during a certain period of time.

In order that the invention may more readily be under- stood, the following description is given, merely by way of example, reference being made to the accompanying draw¬ ings, in which:-

Figure 1 is a side elevation of one embodiment of aerosol device according to the invention; Figure 2 is an enlarged, partly exploded view of the device of Figure 1, with parts being broken away and shown in section;

Figure 3 is an exploded side elevation of device of Figures 1 and 2, with the actuation device being shown in section; Figure 4 is a view similar to the upper part of Figure 3, with the actuation device in position;

Figure 5 is an exploded enlarged perspective view of the counter and actuation member; Figure 6 is a view similar to Figure 4, showing the actuation cap of the actuation member depressed; and

Figure 7 is a perspective view of a second embodiment of aerosol device according to the invention.

Referring first to Figures 1, 2 and 5, the medical spray device illustrated includes a conventional holder 2 and a conventional aerosol container 4 therein. The holder 2 comprises a cylindrical main portion 6, in which the container 4 is received by simply inserting it in an inverted position, whereby a dosing discharge valve having a discharge tube 8 is received in a recess 10. This is formed in an upstanding portion of a bottom wall 12 of the main portion 6. Connected to the recess 10 is a discharge spray nozzle 14, which is surrounded by a laterally extending spout 16. The neck of the container 4 includes the dosing discharge valve, which is actuable for the delivery of a controlled predetermined quantity of fluid from the aerosol container 4, when the container is depressed downwardly to cause the discharge tube 8 to be moved towards the interior of the container. The discharge tube is resiliently biassed, such that all that is necessary is to press the container 4 downwardly in the main portion 6 by finger pressure on the base of the container, whereby the released medicinal dose is discharged via the recess 10 through the nozzle 14 and the spout 16. Only one dose will be produced, irrespective of how long the user holds the container down. When the finger pressure is released, the container will return to its initial position under the action of the' spring bias of the discharge tube 8, without producing any further discharge of medicine. Adjacent the base of the container 4, which is directed upwardly, a counter 20 is provided, this including a holding portion 22 having a lower skirt 24, which engages the circumference of the base portion of the container 4, and an upper actuation cap 26 formed of transparent material. Inside the counter 20 is arranged a counting train which is visible through a lens shaped top 28 of the actuation cap 26. The spray device can be operable by applying finger pressure onto the lens shaped top 28 of the counter, rather than directly on the exposed face of the container. During each actuation, the counter 20 will transfer the required pressure to the container and, at the same time, effect a counting of the actuation, so as to display through the lens shaped top 28 the number of operations or dosages that have been effected since the container 4 and its associated counter were used for the first time. Alternatively, and preferably, the counter unit, when associated with the container or the entire spray device initially, may be designed and adjusted so as to count down the number of actuations from the known number of dosages of the original container. The counter 20 may be designed according to any known counting principle, but need not necessarily be a digital displaying counter, insofar as it achieves the desired result of a physical indication as to the state of the container. This can be marked, e.g., by a red marker coming up into the lens shaped top 28, when there is a predetermined small number of doses remaining in the container.

However, in a preferred construction of the counter, an ordinary mechanical step counter with the required number of digital wheels is provided. This enables the counter to be usable for therapeutic control during the entire lifetime of the container.

The construction of counter shown in Figures 3 to 6 comprises the holding portion 22 and the actuation cap 26, the latter being formed as a short cylinder having its top end providing the lens shaped top 28 and its lower end being provided with an outwardly projecting chamfered flange 30. Inside the actuation cap 26 is arranged a main shaft 32 secured between opposed wall portions of the actuation cap, and a triple wheel digital wheel counter 34. On a second shaft 36 is arranged, but not shown, two transfer wheels forming part of a counter of a well known type. The counter wheels are mounted between two end plates 38,40 which are supported, along their relative edges, against the inside of the actuation cap. The end plate 40 is extended downwardly and is adapted for vertical reciprocation by having a vertical slot 42, through whicht the shaft 32 projects. At its lower left side (Figure 5) the end plate has a pawl 50, which is bent towards the first counter wheel for cooperation with stepping knobs 52 thereon. Thus, the first counter wheel will count a step in response to each upward stroke of the end plate 40.

The holding portion 22 has a cylindrical main body 54, the top end of which has an inwardly projecting chamfered flange 56, while at its lower end, the body 54 has an annular flange 58 just above the skirt 24. In the angle between the flange 58 and the skirt 24 is formed a stepped portion 60.

Between the actuation cap 26 and the holding portion 22 is placed an annular undulating spring 62, which acts between the top side of the annular flange 58 and the annular bottom surface of the actuation cap 26.

The parts 22, 26 and 62 are assembled simply by being pressed together, so that the lower outwardly projecting chamfered flange 30 of the actuation cap 26 will snap under the inwardly projecting chamfered flange 56 of the holding portion 22, thus preventing subsequent separation of these parts. When they are fully pressed together, the spring 62 will become compressed and the end plate 40 is displaced upwardly by contact between its lower flaps 46 and the top side of the annular flange 58. However, the end plate 40 moves against the top portion of the actuation cap 26 so as to be forced down during the last phase of the pressing together of the parts. As a result, due to the shape and position of the flaps 46, which flaps are provided with downwardly converging outer edges 48, these flaps will become forced below the annular flange 58 and will snap out underneath the flange, such that the edge portion of the flange will be received in notches 44, whereafter the end plates 40 will be vertically locked to the flange 58. When the actuation cap is released, the spring 62 will push the actuation cap upwardly until it engages in the flange 56, but the end plate 40 does not participate in this, i.e. it will now be moved so as to prepare the coun¬ ter for actuation by subsequent pressure on the actuation cap . The assembled counter is placed on the base of the container 4, whereby the annular shoulder 60 will provide a free space accommodating the flaps 46 between the end surface of the container base and the underside of the flange 58. Thus, the flaps 46 are not clamped, and it will be possible, therefore, to rotate the actuation cap on the holding portion 22, whereby the user may select any convenient rotational position for the digital counter.

The spring 62 is slightly weaker than, or as strong as, the spring which is provided to bias the discharge nozzle 8 of the container 4.

The operation of the counter will be clear from the foregoing. When the actuation cap 26 is pressed down to the extent that the container delivers a dose (Figure 6), the actuation cap will have been displaced relative to the end plate 40, whereby the counter is actuated and the subsequent release of the button (Figure 5) will cause the counter to become prepared for a subsequent actuation.

Figure 7 shows a modified spray device, in which the container holder, here designated 64, is provided with a counter unit comprising a counter wheel 66. In a manner (not shown) but readily understable to a man skilled in the art, the counter can have an internal actuation member, which is engaged by the neck portion of the container 4, so that depression thereof will cause the counter wheel to rotate one step.

Citas de patentes
Patente citada Fecha de presentación Fecha de publicación Solicitante Título
EP0028929A2 *7 Nov 198020 May 1981Sterwin Ag.Dose indicator for inhalers
EP0114617B1 *12 Ene 198422 Mar 1989Ing. Erich Pfeiffer GmbH & Co. KGManually operable dosage device
GB1317315A * Título no disponible
US3419187 *14 Nov 196731 Dic 1968Peter P. BazarnicDevice for measuring, registering and pouring
US3848774 *24 Ene 197319 Nov 1974Schimke LMeasuring and dispensing cap
US4034757 *16 Jun 197612 Jul 1977Alza CorporationDispenser for pharmaceuticals having patient compliance monitor apparatus
Citada por
Patente citante Fecha de presentación Fecha de publicación Solicitante Título
WO1988002865A1 *5 Oct 198721 Abr 1988Microvol LimitedMethod and apparatus for chemical analysis
WO1991006334A1 *31 Oct 199016 May 1991Smith Kline & French Laboratories LimitedDosage dispensing devices
WO1996003172A1 *13 Ene 19958 Feb 1996New-Med CorporationDispenser monitoring system
WO1996039337A1 *3 Jun 199612 Dic 1996Senetics, Inc.Indicator device responsive to axial force
WO1999057019A3 *30 Abr 199929 Dic 1999Jerry R GrychowskiIndicating device for aerosol container
WO2000021593A124 Ago 199920 Abr 2000Pari GmbH Spezialisten für effektive InhalationActuating device for meters and metering aerosol dispensing device with an actuating device for meters
WO2001028887A1 *11 Oct 200026 Abr 2001Glaxo Group LimitedDevice housing for an aerosol container
WO2001037909A1 *24 Nov 200031 May 2001Ernst Hörlins Ingenjörsbyrå AbCounting mechanism, and spray dose inhaler with said counting mechanism
WO2004009470A2 *17 Jul 200329 Ene 2004Glaxo Group LimitedMedicament dispenser
WO2004009470A3 *17 Jul 20038 Abr 2004Glaxo Group LtdMedicament dispenser
WO2006004498A1 *23 Jun 200512 Ene 2006Astrazeneca AbInhaler device that reduces the risk for miscounting a dosage
WO2007045475A1 *19 Oct 200626 Abr 2007Novartis AgDose counting device
WO2008079350A2 *21 Dic 20073 Jul 2008Schering CorporationDose counter mechanism
WO2008079350A3 *21 Dic 200713 Nov 2008Schering CorpDose counter mechanism
DE19846382C1 *8 Oct 19986 Jul 2000Pari GmbhZählwerk und seine Verwendung in Inhalatoren, Verneblern oder ähnlichen Dosieraerosolvorrichtungen
EP0254391A1 *24 Abr 198727 Ene 1988Glaxo Group LimitedIndicating device for aerosol dispensers
EP0720568A1 *22 Sep 199410 Jul 1996Senetics, Inc.Indicator device responsive to axial force
EP0720568A4 *22 Sep 199427 Ene 1999Senetics IncIndicator device responsive to axial force
EP0775499A3 *19 Nov 199624 Sep 1997Iep Group IncCounters for fluid dispensers
EP1131248A2 *30 Abr 199912 Sep 2001Ontario Inc. 1263152Indicating device for aerosol container
EP1131248A4 *30 Abr 199912 Ene 2005Inc OntarioIndicating device for aerosol container
EP1570877A1 *3 Mar 20057 Sep 2005Fujisawa Deutschland GmbHDose counter for inhalers with trigger means
US4817822 *24 Abr 19874 Abr 1989Glaxo Group LimitedIndicating device
US4934358 *20 Mar 198719 Jun 1990Sven-Erik NilssonDevice for self-administration of physiologically active substances, with prevention of overdosing
US5421482 *22 Sep 19936 Jun 1995Senetics, Inc.Indicator device responsive to axial force
US5505192 *25 Jul 19949 Abr 1996New-Med CorporationDispenser monitoring system
US5505195 *16 Sep 19939 Abr 1996Medtrac Technologies Inc.Dry powder inhalant device with dosage and air flow monitor
US5564414 *26 May 199415 Oct 1996Walker; William F.Pressurized and metered medication dose counter on removable sleeve
US5622163 *22 Nov 199522 Abr 1997Iep Group, Inc.Counter for fluid dispensers
US5718355 *6 Jun 199517 Feb 1998Senetics, Inc.Indicator device responsive to axial force for use with inhaler
US648143824 Ago 199919 Nov 2002Pari Gmbh Spezialisten Fur Effetive InhalationMeter
US667925124 Ago 199920 Ene 2004Pari Gmbh Spezialisten Fur Effektive InhalationActuating device for meters and metering aerosol dispensing device with an actuating device for meters
US724968717 Jul 200331 Jul 2007Glaxo Group LimitedMedicament dispenser
US766142326 Feb 200316 Feb 2010Glaxosmithkline LlcDevice housing for an aerosol container
US807459410 Ago 200913 Dic 2011Trudell Medical InternationalDose indicating device
US815712823 Jun 201117 Abr 2012Trudell Medical InternationalIndicating device
US850577327 Mar 201213 Ago 2013Trudell Medical InternationalIndicating device
US852854523 Jun 200510 Sep 2013Astrazeneca AbInhaler device that reduces the risk for miscounting a dosage
US857893414 Oct 200912 Nov 2013Trudell Medical InternationalIndicating device with warning dosage indicator
US859626522 Oct 20093 Dic 2013Trudell Medical InternationalModular aerosol delivery system
US861619623 Jun 200531 Dic 2013Astrazeneca AbInhalation device and a method for assembling said inhalation device
US86620757 Dic 20114 Mar 2014Trudell Medical InternationalDispensing device
US88697357 Dic 201128 Oct 2014Trudell Medical International, Inc.Dose indicating device
US89442859 Jul 20133 Feb 2015Trudell Medical InternationalIndicating device
US897378429 Ene 200910 Mar 2015Trudell Medical InternationalDispensing device
US903295315 Feb 201219 May 2015Trudell Medical InternationalModular aerosol delivery system
US916834323 Ene 201427 Oct 2015Trudell Medical InternationalDispensing device
US92420577 Nov 201326 Ene 2016Trudell Medical InternationalModular aerosol delivery system
US92659017 Mar 201223 Feb 2016Trudell Medical InternationalDispensing device
US964945514 Ene 201516 May 2017Trudell Medical InternationalIndicating device
US965603225 Feb 201523 May 2017Trudell Medical InternationalDispensing device
Clasificaciones
Clasificación internacionalB65D83/14, A61M11/08, A61M15/00
Clasificación cooperativaB65D83/54, B65D83/38, A61M15/0068, A61M15/009, A61M15/0076
Clasificación europeaB65D83/38, A61M15/00P
Eventos legales
FechaCódigoEventoDescripción
24 Abr 1986ALDesignated countries for regional patents
Kind code of ref document: A1
Designated state(s): AT BE CF CG CH CM DE FR GA GB IT LU ML MR NL SE SN TD TG
24 Abr 1986AKDesignated states
Kind code of ref document: A1
Designated state(s): AT AU BB BG BR CH DE DE DK FI GB HU JP KP KR LK LU MC MG MW NL NO RO SD SE SU US
23 May 1986WWEWipo information: entry into national phase
Ref document number: 1985905131
Country of ref document: EP
6 Jun 1986WWEWipo information: entry into national phase
Ref document number: 862440
Country of ref document: FI
21 Ago 1986REGReference to national code
Ref country code: DE
Ref legal event code: 8642
15 Oct 1986WWPWipo information: published in national office
Ref document number: 1985905131
Country of ref document: EP
12 Feb 1988WWWWipo information: withdrawn in national office
Ref document number: 1985905131
Country of ref document: EP