WO1986004684A1 - Method for the determination of antibodies or antigens - Google Patents
Method for the determination of antibodies or antigens Download PDFInfo
- Publication number
- WO1986004684A1 WO1986004684A1 PCT/FI1986/000014 FI8600014W WO8604684A1 WO 1986004684 A1 WO1986004684 A1 WO 1986004684A1 FI 8600014 W FI8600014 W FI 8600014W WO 8604684 A1 WO8604684 A1 WO 8604684A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- particles
- layer
- fluorescent
- reaction
- sample
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI864044A FI864044A (en) | 1985-02-06 | 1986-10-06 | FOERFARANDE FOER BESTAEMNING AV MOTMEDEL ELLER ANTIGENER. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI850481A FI850481A0 (en) | 1985-02-06 | 1985-02-06 | FOERFARANDE FOER BESTAEMNING AV MOTMEDEL ELLER ANTIGENER. |
FI850481 | 1985-02-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1986004684A1 true WO1986004684A1 (en) | 1986-08-14 |
Family
ID=8520326
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FI1986/000014 WO1986004684A1 (en) | 1985-02-06 | 1986-02-05 | Method for the determination of antibodies or antigens |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0214167A1 (en) |
JP (1) | JPS62501647A (en) |
FI (1) | FI850481A0 (en) |
WO (1) | WO1986004684A1 (en) |
Cited By (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0247796A1 (en) * | 1986-05-22 | 1987-12-02 | Unilever Plc | Solid phase immunoassay method |
WO1989001161A1 (en) * | 1987-07-28 | 1989-02-09 | International Institute Of Cellular & Molecular Pa | Turbidimetric assay |
WO1989003533A1 (en) * | 1987-10-09 | 1989-04-20 | Nygene Corporation | Process for detecting biochemical species and apparatus useful therein |
WO1989011102A1 (en) * | 1988-05-04 | 1989-11-16 | Angenics, Inc. | Capillary flow device and double capture assay method |
DE3840462A1 (en) * | 1988-12-01 | 1990-06-07 | Berthold Lab Prof R | METHOD AND DEVICE FOR MEASURING CHEMILUMINESCENCE |
EP0388940A1 (en) * | 1989-03-23 | 1990-09-26 | Hamamatsu Photonics K.K. | Method of modifying the surface of a magnetic particle |
GB2236852A (en) * | 1989-09-25 | 1991-04-17 | Scotgen Ltd | DNA probe/antibody based assays and intermediates useful in the synthesis of cleavable nucleic acids for use in such assays |
US5071774A (en) * | 1983-04-05 | 1991-12-10 | Syntex (U.S.A.) Inc. | Multiparameter particle analysis |
US5145784A (en) * | 1988-05-04 | 1992-09-08 | Cambridge Biotech Corporation | Double capture assay method employing a capillary flow device |
US5238810A (en) * | 1986-09-22 | 1993-08-24 | Nippon Telegraph And Telephone Corporation | Laser magnetic immunoassay method and apparatus thereof |
US5252493A (en) * | 1986-09-22 | 1993-10-12 | Nippon Telegraph And Telephone Corporation | Laser magnetic immunoassay method and apparatus therefor |
US5279936A (en) * | 1989-12-22 | 1994-01-18 | Syntex (U.S.A.) Inc. | Method of separation employing magnetic particles and second medium |
GB2270158A (en) * | 1992-08-03 | 1994-03-02 | Marconi Gec Ltd | Immunoassay using two detectable species |
GB2270976A (en) * | 1992-09-18 | 1994-03-30 | Marconi Gec Ltd | Immunoassay/separation process using an auxiliary species on a support |
EP0690987A1 (en) * | 1993-03-22 | 1996-01-10 | Zynaxis Inc. | Immunoassay for determination of cells |
WO1996031777A1 (en) * | 1995-04-03 | 1996-10-10 | Macquarie Research Limited | Method for detecting microorganisms |
US5723304A (en) * | 1992-08-03 | 1998-03-03 | Gec-Marconi Limited | Immunological detection using two detectable labels |
US7358099B2 (en) | 2002-01-15 | 2008-04-15 | Binax, Inc. | Process for (A) separating biological/ligands from dilute solutions and (B) conducting an immunochromatographic assay thereof employing superparamagnetic particles throughout |
US9057046B2 (en) | 2005-09-26 | 2015-06-16 | Rapid Micro Biosystems, Inc. | Cassette containing growth medium |
US9090462B2 (en) | 2001-09-06 | 2015-07-28 | Rapid Micro Biosystems, Inc. | Rapid detection of replicating cells |
CN104995513A (en) * | 2012-07-03 | 2015-10-21 | 里兰斯坦福初级大学理事会 | Scalable bio-element analysis |
US9643180B2 (en) | 2008-09-24 | 2017-05-09 | First Light Biosciences, Inc. | Method for detecting analytes |
US9745546B2 (en) | 2011-11-07 | 2017-08-29 | Rapid Micro Biosystems, Inc. | Cassette for sterility testing |
CN107192818A (en) * | 2017-05-23 | 2017-09-22 | 重庆天之助生物科技有限公司 | A kind of particulate colourity clustering method and kit |
US9803230B2 (en) | 2013-03-15 | 2017-10-31 | Abbott Molecular Inc. | One-step procedure for the purification of nucleic acids |
US10350595B2 (en) | 2016-11-14 | 2019-07-16 | Orca Biosystems, Inc. | Methods and apparatuses for sorting target particles |
US10370653B2 (en) | 2015-02-22 | 2019-08-06 | The Board Of Trustees Of The Leland Stanford Junior University | Micro-screening apparatus, process, and products |
US10407707B2 (en) | 2012-04-16 | 2019-09-10 | Rapid Micro Biosystems, Inc. | Cell culturing device |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006255817A (en) * | 2005-03-16 | 2006-09-28 | Sonac Kk | Metal structure and its manufacturing method |
WO2012086243A1 (en) * | 2010-12-21 | 2012-06-28 | 株式会社 島津製作所 | Device and method for processing target component in tube |
JPWO2015046293A1 (en) * | 2013-09-30 | 2017-03-09 | 凸版印刷株式会社 | Test substance detection system |
JP7347849B2 (en) * | 2018-04-19 | 2023-09-20 | ファースト ライト ダイアグノスティクス, インコーポレイテッド | Target detection |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4115535A (en) * | 1977-06-22 | 1978-09-19 | General Electric Company | Diagnostic method employing a mixture of normally separable protein-coated particles |
US4125375A (en) * | 1975-11-14 | 1978-11-14 | National Research Development Corporation | Separation of solid and liquid components of mixtures |
EP0002963A1 (en) * | 1977-12-28 | 1979-07-11 | EASTMAN KODAK COMPANY (a New Jersey corporation) | Aqueous stabilized fluorescent labels, proteins labelled therewith and methods of use |
US4434150A (en) * | 1981-10-19 | 1984-02-28 | Ortho Diagnostic Systems, Inc. | Immunological reagents employing polymeric backbone possessing reactive functional groups |
EP0149565A2 (en) * | 1984-01-19 | 1985-07-24 | Kodak Clinical Diagnostics Limited | Assay method |
EP0157197A2 (en) * | 1984-03-14 | 1985-10-09 | Labsystems Oy | Method for carrying out immunofluorescent assays |
EP0169434A2 (en) * | 1984-07-26 | 1986-01-29 | Labsystems Oy | Immunological assay method |
-
1985
- 1985-02-06 FI FI850481A patent/FI850481A0/en not_active Application Discontinuation
-
1986
- 1986-02-05 EP EP19860901081 patent/EP0214167A1/en not_active Ceased
- 1986-02-05 WO PCT/FI1986/000014 patent/WO1986004684A1/en not_active Application Discontinuation
- 1986-02-05 JP JP50102486A patent/JPS62501647A/en active Pending
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4125375A (en) * | 1975-11-14 | 1978-11-14 | National Research Development Corporation | Separation of solid and liquid components of mixtures |
US4115535A (en) * | 1977-06-22 | 1978-09-19 | General Electric Company | Diagnostic method employing a mixture of normally separable protein-coated particles |
EP0002963A1 (en) * | 1977-12-28 | 1979-07-11 | EASTMAN KODAK COMPANY (a New Jersey corporation) | Aqueous stabilized fluorescent labels, proteins labelled therewith and methods of use |
US4434150A (en) * | 1981-10-19 | 1984-02-28 | Ortho Diagnostic Systems, Inc. | Immunological reagents employing polymeric backbone possessing reactive functional groups |
EP0149565A2 (en) * | 1984-01-19 | 1985-07-24 | Kodak Clinical Diagnostics Limited | Assay method |
EP0157197A2 (en) * | 1984-03-14 | 1985-10-09 | Labsystems Oy | Method for carrying out immunofluorescent assays |
EP0169434A2 (en) * | 1984-07-26 | 1986-01-29 | Labsystems Oy | Immunological assay method |
Non-Patent Citations (1)
Title |
---|
Chemical Abstracts vol 96 (1982), abstract 1738126, J Clin Chem Clin Biochem 1982, 20 (3), 151-6 * |
Cited By (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5071774A (en) * | 1983-04-05 | 1991-12-10 | Syntex (U.S.A.) Inc. | Multiparameter particle analysis |
WO1987007386A1 (en) * | 1986-05-22 | 1987-12-03 | Unilever Plc | Solid phase immunoassay method |
EP0247796A1 (en) * | 1986-05-22 | 1987-12-02 | Unilever Plc | Solid phase immunoassay method |
US5252493A (en) * | 1986-09-22 | 1993-10-12 | Nippon Telegraph And Telephone Corporation | Laser magnetic immunoassay method and apparatus therefor |
US5238810A (en) * | 1986-09-22 | 1993-08-24 | Nippon Telegraph And Telephone Corporation | Laser magnetic immunoassay method and apparatus thereof |
WO1989001161A1 (en) * | 1987-07-28 | 1989-02-09 | International Institute Of Cellular & Molecular Pa | Turbidimetric assay |
WO1989003533A1 (en) * | 1987-10-09 | 1989-04-20 | Nygene Corporation | Process for detecting biochemical species and apparatus useful therein |
WO1989011102A1 (en) * | 1988-05-04 | 1989-11-16 | Angenics, Inc. | Capillary flow device and double capture assay method |
US5145784A (en) * | 1988-05-04 | 1992-09-08 | Cambridge Biotech Corporation | Double capture assay method employing a capillary flow device |
DE3840462A1 (en) * | 1988-12-01 | 1990-06-07 | Berthold Lab Prof R | METHOD AND DEVICE FOR MEASURING CHEMILUMINESCENCE |
US5019416A (en) * | 1989-03-23 | 1991-05-28 | Hamamatsu Photonics K. K. | Method of modifying the surface of a particle comprising a magnetic particle |
EP0388940A1 (en) * | 1989-03-23 | 1990-09-26 | Hamamatsu Photonics K.K. | Method of modifying the surface of a magnetic particle |
GB2236852A (en) * | 1989-09-25 | 1991-04-17 | Scotgen Ltd | DNA probe/antibody based assays and intermediates useful in the synthesis of cleavable nucleic acids for use in such assays |
GB2236852B (en) * | 1989-09-25 | 1994-04-06 | Scotgen Ltd | DNA probe based assays and intermediates useful in the synthesis of cleavable nucleic acids for use in such assays |
US5279936A (en) * | 1989-12-22 | 1994-01-18 | Syntex (U.S.A.) Inc. | Method of separation employing magnetic particles and second medium |
US5770388A (en) * | 1989-12-22 | 1998-06-23 | Dade Behring Marburg Gmbh | Method of separation employing magnetic particles and second medium |
GB2270158A (en) * | 1992-08-03 | 1994-03-02 | Marconi Gec Ltd | Immunoassay using two detectable species |
GB2270158B (en) * | 1992-08-03 | 1997-03-19 | Marconi Gec Ltd | Detection |
US5723304A (en) * | 1992-08-03 | 1998-03-03 | Gec-Marconi Limited | Immunological detection using two detectable labels |
GB2270976A (en) * | 1992-09-18 | 1994-03-30 | Marconi Gec Ltd | Immunoassay/separation process using an auxiliary species on a support |
EP0690987A1 (en) * | 1993-03-22 | 1996-01-10 | Zynaxis Inc. | Immunoassay for determination of cells |
EP0690987A4 (en) * | 1993-03-22 | 1998-02-25 | Zynaxis Inc | Immunoassay for determination of cells |
WO1996031777A1 (en) * | 1995-04-03 | 1996-10-10 | Macquarie Research Limited | Method for detecting microorganisms |
US6225046B1 (en) | 1995-04-03 | 2001-05-01 | Macquarie Research Ltd. | Method for detecting microorganisms |
US9290382B2 (en) | 2001-09-06 | 2016-03-22 | Rapid Micro Biosystems | Rapid detection of replicating cells |
US11499176B2 (en) | 2001-09-06 | 2022-11-15 | Rapid Micro Biosystems, Inc. | Rapid detection of replicating cells |
US9090462B2 (en) | 2001-09-06 | 2015-07-28 | Rapid Micro Biosystems, Inc. | Rapid detection of replicating cells |
US10000788B2 (en) | 2001-09-06 | 2018-06-19 | First Light Biosciences, Inc. | Rapid and sensitive detection of molecules |
US7358099B2 (en) | 2002-01-15 | 2008-04-15 | Binax, Inc. | Process for (A) separating biological/ligands from dilute solutions and (B) conducting an immunochromatographic assay thereof employing superparamagnetic particles throughout |
US9057046B2 (en) | 2005-09-26 | 2015-06-16 | Rapid Micro Biosystems, Inc. | Cassette containing growth medium |
US11865534B2 (en) | 2008-09-24 | 2024-01-09 | First Light Diagnostics, Inc. | Imaging analyzer for testing analytes |
US9643180B2 (en) | 2008-09-24 | 2017-05-09 | First Light Biosciences, Inc. | Method for detecting analytes |
US11583853B2 (en) | 2008-09-24 | 2023-02-21 | First Light Diagnostics, Inc. | Kits and devices for detecting analytes |
US10384203B2 (en) | 2008-09-24 | 2019-08-20 | First Light Biosciences, Inc. | Kits and devices for detecting analytes |
US9745546B2 (en) | 2011-11-07 | 2017-08-29 | Rapid Micro Biosystems, Inc. | Cassette for sterility testing |
US11788046B2 (en) | 2011-11-07 | 2023-10-17 | Rapid Micro Biosystems, Inc. | Cassette for sterility testing |
US10801004B2 (en) | 2011-11-07 | 2020-10-13 | Rapid Micro Biosystems, Inc. | Cassette for sterility testing |
US10407707B2 (en) | 2012-04-16 | 2019-09-10 | Rapid Micro Biosystems, Inc. | Cell culturing device |
US11643677B2 (en) | 2012-04-16 | 2023-05-09 | Rapid Micro Biosystems, Inc. | Cell culturing device |
CN104995513A (en) * | 2012-07-03 | 2015-10-21 | 里兰斯坦福初级大学理事会 | Scalable bio-element analysis |
US10788506B2 (en) | 2012-07-03 | 2020-09-29 | The Board Of Trustees Of The Leland Stanford Junior University | Scalable bio-element analysis |
EP4056702A3 (en) * | 2012-07-03 | 2022-10-05 | The Board of Trustees of the Leland Stanford Junior University | Scalable bio-element analysis |
EP3460060A3 (en) * | 2012-07-03 | 2019-06-12 | The Board Of Trustees Of The University Of the Leland Stanford Junior University | Scalable bio-element analysis |
CN104995513B (en) * | 2012-07-03 | 2017-11-21 | 里兰斯坦福初级大学理事会 | Can the analysis of scale bio-element |
US9803230B2 (en) | 2013-03-15 | 2017-10-31 | Abbott Molecular Inc. | One-step procedure for the purification of nucleic acids |
US10526600B2 (en) | 2015-02-22 | 2020-01-07 | The Board Of Trustees Of The Leland Stanford Junior University | Micro-screening apparatus, process, and products |
US10370653B2 (en) | 2015-02-22 | 2019-08-06 | The Board Of Trustees Of The Leland Stanford Junior University | Micro-screening apparatus, process, and products |
US10722885B2 (en) | 2016-11-14 | 2020-07-28 | Orca Biosystems, Inc. | Methods and apparatuses for sorting target particles |
US11471885B2 (en) | 2016-11-14 | 2022-10-18 | Orca Biosystems, Inc. | Methods and apparatuses for sorting target particles |
US10350595B2 (en) | 2016-11-14 | 2019-07-16 | Orca Biosystems, Inc. | Methods and apparatuses for sorting target particles |
CN107192818A (en) * | 2017-05-23 | 2017-09-22 | 重庆天之助生物科技有限公司 | A kind of particulate colourity clustering method and kit |
Also Published As
Publication number | Publication date |
---|---|
EP0214167A1 (en) | 1987-03-18 |
JPS62501647A (en) | 1987-07-02 |
FI850481A0 (en) | 1985-02-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO1986004684A1 (en) | Method for the determination of antibodies or antigens | |
US4777145A (en) | Immunological assay method using magnetic particles | |
US5558839A (en) | Magnetic device for immunological analysis of a solid phase | |
US5374531A (en) | Immunoassay for determination of cells | |
EP0149565B1 (en) | Assay method | |
US4098876A (en) | Reverse sandwich immunoassay | |
US4659678A (en) | Immunoassay of antigens | |
US5145784A (en) | Double capture assay method employing a capillary flow device | |
US5501949A (en) | Particle bound binding component immunoassay | |
EP0559738B1 (en) | Methods for detection and quantitation of cell subsets within subpopulations of a mixed cell population | |
EP1532448B1 (en) | Self-calibration system for a magnetic binding assay | |
US6645776B2 (en) | Electrical excitation of label substances at insulating film-coated conductors | |
CN1008403B (en) | Method and apparatus for immunoassays | |
EP0105714A1 (en) | Immunoassay of antigens | |
WO2004021006A1 (en) | Fluidics-based assay devices | |
EP0301584B1 (en) | Immunological measuring method | |
EP0397659A4 (en) | Process for detecting biochemical species and apparatus useful therein | |
WO1989011102A1 (en) | Capillary flow device and double capture assay method | |
Llopis et al. | A new microplate red blood cell monolayer technique for screening and identifying red blood cell antibodies | |
CA2035305A1 (en) | Immunochemical assay method with plural items | |
JPH04203968A (en) | Method for measuring chemical emission immunity | |
JPH0244254A (en) | Multiple parameter particle analysis | |
JPH07333225A (en) | Immunoassay enhanced in sensitivity |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): FI JP SU US |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): AT BE CH DE FR GB IT LU NL SE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1986901081 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 864044 Country of ref document: FI |
|
WWP | Wipo information: published in national office |
Ref document number: 1986901081 Country of ref document: EP |
|
WWR | Wipo information: refused in national office |
Ref document number: 1986901081 Country of ref document: EP |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 1986901081 Country of ref document: EP |