WO1987005536A1 - Method and apparatus for collecting and dispersing ferromagnetic particles in a fluid medium - Google Patents

Method and apparatus for collecting and dispersing ferromagnetic particles in a fluid medium Download PDF

Info

Publication number
WO1987005536A1
WO1987005536A1 PCT/SE1987/000120 SE8700120W WO8705536A1 WO 1987005536 A1 WO1987005536 A1 WO 1987005536A1 SE 8700120 W SE8700120 W SE 8700120W WO 8705536 A1 WO8705536 A1 WO 8705536A1
Authority
WO
WIPO (PCT)
Prior art keywords
sleeve
nose
passageway
magnet
permanent magnet
Prior art date
Application number
PCT/SE1987/000120
Other languages
French (fr)
Inventor
Ulf SCHRÖDER
Original Assignee
Carbomatrix Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carbomatrix Ab filed Critical Carbomatrix Ab
Publication of WO1987005536A1 publication Critical patent/WO1987005536A1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/28—Magnetic plugs and dipsticks
    • B03C1/284—Magnetic plugs and dipsticks with associated cleaning means, e.g. retractable non-magnetic sleeve
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00459—Beads
    • B01J2219/00468—Beads by manipulation of individual beads

Definitions

  • the present invention relates to a method and an apparatus for collecting and dispersing ferromag ⁇ netic particles in a fluid medium.
  • US-3,985,649 discloses a process for separating a substance from a liquid in a container utilising magnetic forces.
  • the substance is formed of ferromag ⁇ netic particles which are actuated, for the said sepa ⁇ ration, by means of an electromagnet immersed in the liquid.
  • the ferromagnetic particles may have been formed of a ferromagnetic core and a reaction product bonded thereto, optionally via a coating, and formed of a first reactant bonded to the core or the coating prior to the introduction of the cores into the liquid, and a second reactant within the liquid.
  • the electro ⁇ magnet is energised and then attracts the particles and can be removed from the liquid and the container together with the particles.
  • the ferromagnetic particles thus removed from the liquid and the reaction product which may be bonded thereto, can be subjected to further processing steps in other liquids, in which case the electromagnet may be deenergised.
  • the electrical lead-ins of the elec- tromagnet constitute an obstacle to easy and convenient handling of the magnet.
  • the thin-walled, nose-shaped end of the plastic sleeve which is permeable in respect of magnetism but free of remanence, causes the ferromagnetic par- tides to collect around this end when the permanent magnet is inserted therein, the shoulder interconnect ⁇ ing the nose and the relatively thick jacket wall preventing said particles from following, on the outer side of said jacket wall, the movement of the magnet when displaced from the nose in order to disperse the particles.
  • the sleeve preferably is an inexpensive mass- produced single-service plastic product for collect ⁇ ing and dispersing the ferromagnetic particles.
  • the invention will now be described in more detail, reference being had to the accompanying drawing illu ⁇ strating an uncomplicated basic embodiment of an appa ⁇ ratus for carrying the method according to the inven ⁇ tion into effect.
  • a test tube 1 contains a liquid 2 with ferromagnetic particles 3.
  • An apparatus accord ⁇ ing to the invention, or a probe, for collecting and dispersing these particles is designated 4. It com ⁇ prises a cylindrical, for example injection-moulded plastic sleeve 5 having a closed nose-shaped end 6.
  • the sleeve 5 has a passageway 7 which is of uniform width and extends from the open end 8 of the sleeve into the nose 6.
  • the nose 6 thus has a thinner jacket wall than the body 9 of the sleeve, and also a thin end wall.
  • the passageway 7 accommodates a permanent magnet 10 for reciprocal movement within the passage ⁇ way 7 in the longitudinal direction thereof by means of a shank 11 attached to said magnet in some suitable manner and extending through the open end 8.
  • a coiled spring 12 may be positioned between a flange 13 on the shank and a flange 14 on the sleeve.
  • the plastic material for the sleeve is so select ⁇ ed that it is permeable to the magnetic field of the magnet 10 at the thin nose wall, but less permeable to this field via the thicker body wall 9.
  • the plastic material has minimum residual magnetism (remanence), if any at all.
  • the magnet 10 When the probe 4 is inserted in the tube 1 and the magnet 10 is moved into the nose 6, the spring 12 being compressed between the flanges 13 and 14 which are held between the fingers of one hand, the ferromagnetic particles 3 will collect on and adhere to the nose.
  • the magnet When the magnet is moved in the opposite direction, which may be achieved by easing the finger pressure on the flange 13, the particles 3 are released from the sleeve 5. They cannot accompany the magnet 10 in its upward movement because of the shoulder between the nose 6 and the jacket wall 9 of the body.
  • magnetic particles 3 to which adheres a reactant/reaction product/absorbent/adsorbent or the like originating in the liquid 2 are transferred to another test tube containing another liquid for reaction or further treatment therein, after dispersion in said other liquid.
  • the construction described above is a basic one. It may be made more sophisticated in a manner obvious to those skilled in the art by providing, for example, means for locking the magnet 10 in the collecting position and the releasing/dispersing position, for example by means of a mechanism resembling the mechanism of a ballpoint pen for locking the retracted and ex ⁇ tended positions of a spring-loaded ink cartridge.
  • a person skilled in the art will have no difficulty in devising a mechanism to provide for rotatability of the sleeve 5 about the shank 11 and the magnet 10 by the same hand which effects longitudinal movement of the magnet 10. Such rotation may be accomplished by means of a rack and gear mechanism, a clock-winding spring, etc.
  • the advantage of having a rotatable sleeve 5, especially if the sleeve is provided with wings, is that the liquid and the ferromagnetic particles there ⁇ in can be agitated, possibly after they have been released by the sleeve 5.

Abstract

A method and apparatus for collecting ferromagnetic particles in a gaseous or liquid medium, and dispersing them in a gaseous or liquid medium, in which method a magnet is introduced into said medium. Use is made of a sleeve (5) of a plastic material permeable to the magnetic field, but free of remanence and having a thin-walled nose end (6) and a thick-walled jacket wall. Mounted in the passageway (7) of the sleeve is a permanent magnet body (10) of the type which, when attached to an operating means (11, 13), is movable within said passageway in the longitudinal direction thereof by means of said operating means from the open sleeve end, the permanent magnet being moved by means of said operating means into the closed nose end for collecting the ferromagnetic particles (3). To disperse the particles, the permanent magnet is moved to a position spaced from the nose.

Description

METHOD AND APPARATUS FOR COLLECTING AND DISPERSING FERROMAGNETIC PARTICLES IN A FLUID MEDIUM
The present invention relates to a method and an apparatus for collecting and dispersing ferromag¬ netic particles in a fluid medium.
US-3,985,649 discloses a process for separating a substance from a liquid in a container utilising magnetic forces. The substance is formed of ferromag¬ netic particles which are actuated, for the said sepa¬ ration, by means of an electromagnet immersed in the liquid. The ferromagnetic particles may have been formed of a ferromagnetic core and a reaction product bonded thereto, optionally via a coating, and formed of a first reactant bonded to the core or the coating prior to the introduction of the cores into the liquid, and a second reactant within the liquid. For the said actuation of the ferromagnetic particles, the electro¬ magnet is energised and then attracts the particles and can be removed from the liquid and the container together with the particles.
The ferromagnetic particles thus removed from the liquid and the reaction product which may be bonded thereto, can be subjected to further processing steps in other liquids, in which case the electromagnet may be deenergised.
One disadvantage of this technique is that, after the electromagnet has been deenergised, a multitude of the ferromagnetic particles are retained by the electromagnet due to residual magnetism (remanence). If, for example, the separated particles are to be analysed in respect of reaction yield, the analysis will be inaccurate. The alternative of removing this particle quantity from the electromagnet takes a fairly long time, and this is also the case if the electromag¬ net is to be cleaned for reuse in a new environment that must not be contaminated by residual particles originating from a previous use of the electromagnet for the purpose in question.
Furthermore, the electrical lead-ins of the elec- tromagnet constitute an obstacle to easy and convenient handling of the magnet.
It is the object of this invention to eliminate these shortcomings.
This object is achieved by means of a method and an apparatus which has the characteristic features stated in the claims.
The thin-walled, nose-shaped end of the plastic sleeve which is permeable in respect of magnetism but free of remanence, causes the ferromagnetic par- tides to collect around this end when the permanent magnet is inserted therein, the shoulder interconnect¬ ing the nose and the relatively thick jacket wall preventing said particles from following, on the outer side of said jacket wall, the movement of the magnet when displaced from the nose in order to disperse the particles.
The sleeve preferably is an inexpensive mass- produced single-service plastic product for collect¬ ing and dispersing the ferromagnetic particles. The invention will now be described in more detail, reference being had to the accompanying drawing illu¬ strating an uncomplicated basic embodiment of an appa¬ ratus for carrying the method according to the inven¬ tion into effect. A test tube 1 contains a liquid 2 with ferromagnetic particles 3. An apparatus accord¬ ing to the invention, or a probe, for collecting and dispersing these particles is designated 4. It com¬ prises a cylindrical, for example injection-moulded plastic sleeve 5 having a closed nose-shaped end 6. The sleeve 5 has a passageway 7 which is of uniform width and extends from the open end 8 of the sleeve into the nose 6. The nose 6 thus has a thinner jacket wall than the body 9 of the sleeve, and also a thin end wall. The passageway 7 accommodates a permanent magnet 10 for reciprocal movement within the passage¬ way 7 in the longitudinal direction thereof by means of a shank 11 attached to said magnet in some suitable manner and extending through the open end 8. To effect the reciprocal movement, a coiled spring 12 may be positioned between a flange 13 on the shank and a flange 14 on the sleeve. The plastic material for the sleeve is so select¬ ed that it is permeable to the magnetic field of the magnet 10 at the thin nose wall, but less permeable to this field via the thicker body wall 9. The plastic material has minimum residual magnetism (remanence), if any at all.
When the probe 4 is inserted in the tube 1 and the magnet 10 is moved into the nose 6, the spring 12 being compressed between the flanges 13 and 14 which are held between the fingers of one hand, the ferromagnetic particles 3 will collect on and adhere to the nose. When the magnet is moved in the opposite direction, which may be achieved by easing the finger pressure on the flange 13, the particles 3 are released from the sleeve 5. They cannot accompany the magnet 10 in its upward movement because of the shoulder between the nose 6 and the jacket wall 9 of the body. In this manner, magnetic particles 3 to which adheres a reactant/reaction product/absorbent/adsorbent or the like originating in the liquid 2, are transferred to another test tube containing another liquid for reaction or further treatment therein, after dispersion in said other liquid.
The construction described above is a basic one. It may be made more sophisticated in a manner obvious to those skilled in the art by providing, for example, means for locking the magnet 10 in the collecting position and the releasing/dispersing position, for example by means of a mechanism resembling the mechanism of a ballpoint pen for locking the retracted and ex¬ tended positions of a spring-loaded ink cartridge. Bearing these locking means in mind, a person skilled in the art will have no difficulty in devising a mechanism to provide for rotatability of the sleeve 5 about the shank 11 and the magnet 10 by the same hand which effects longitudinal movement of the magnet 10. Such rotation may be accomplished by means of a rack and gear mechanism, a clock-winding spring, etc. The advantage of having a rotatable sleeve 5, especially if the sleeve is provided with wings, is that the liquid and the ferromagnetic particles there¬ in can be agitated, possibly after they have been released by the sleeve 5.

Claims

1. A method of collecting ferromagnetic particles to which is bonded a reactant/reaction product/bonding agent or the like, in a first gaseous or liquid medium, and dispersing them in a second gaseous or liquid medium, in which method use is made of a magnet for actuation of said ferromagnetic particles, c h a ¬ r a c t e r i s e d by utilising a sleeve of plastic material permeable to the magnetic field, but free of remanence and having a thin-walled closed nose end and a thick-walled jacket wall; providing within the passageway of said sleeve a permanent magnet body of the type which, when attached to an operating means, is movable within the passageway from the open sleeve end by means of said operating means in the longitudinal direction of said passageway; moving said permanent magnet within said sleeve, with the sleeve end inserted in said first medium, into said nose end by means of said operating means, for collecting the ferromag¬ netic particles within said first medium; and moving said permanent magnet, with the sleeve end inserted in said second medium, from the position inserted in said nose end to a position within said sleeve spaced from said nose end, for dispersing said par¬ ticles in said second medium.
2. A method as claimed in claim 1, c h a r a c ¬ t e r i s e d in that the ferromagnetic particles are transferred, with the magnet inserted in the nose, from a liquid in a first container to a liquid in a second container in which the particles are released by moving the magnet to a position spaced from the nose.
3. An apparatus for carrying the method as claimed in any one of claims 1 and 2 into effect, c h a r a c ¬ t e r i s e d in that it comprises a cylindrical sleeve (5) of plastic material permeable to the magnetic field, but free of remanence and having a closed nose- shaped end (6) and a passageway (7) extending from the open sleeve end into the nose, said passageway accommodating a permanent magnet (10) which is movable in the longitudinal direction of said passageway and connected to an operating means (11, 13) for the said movement.
4. An apparatus as claimed in claim 3, c h a¬ r a c t e r i s e d in that a spring (12) is adapted to effect movement of the permanent magnet.
5. An apparatus as claimed in any one of claims 3 and 4, c h a r a c t e r i s e d in that said sleeve (5) is rotatable relative to said magnet (10).
PCT/SE1987/000120 1986-03-12 1987-03-11 Method and apparatus for collecting and dispersing ferromagnetic particles in a fluid medium WO1987005536A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8601143-3 1986-03-12
SE8601143A SE8601143L (en) 1986-03-12 1986-03-12 SET AND DEVICE FOR COLLECTION AND DISTRIBUTION OF FERROMAGNETIC PARTICLES IN A FLUID MEDIUM

Publications (1)

Publication Number Publication Date
WO1987005536A1 true WO1987005536A1 (en) 1987-09-24

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE1987/000120 WO1987005536A1 (en) 1986-03-12 1987-03-11 Method and apparatus for collecting and dispersing ferromagnetic particles in a fluid medium

Country Status (3)

Country Link
AU (1) AU7127787A (en)
SE (1) SE8601143L (en)
WO (1) WO1987005536A1 (en)

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FR2679660A1 (en) * 1991-07-22 1993-01-29 Pasteur Diagnostics METHOD AND MAGNETIC DEVICE FOR IMMUNOLOGICAL ANALYSIS ON A SOLID PHASE.
WO1994018565A1 (en) * 1993-02-01 1994-08-18 Labsystems Oy Method and means for magnetic particle specific binding assay
WO1995000247A1 (en) * 1993-06-21 1995-01-05 Labsystems Oy Separation method
FR2710632A1 (en) * 1993-09-28 1995-04-07 Mercier Dominique Device for magnetic sensing with mechanical cleaning and its use for the removal of sludge from heating circuits
EP0687505A1 (en) * 1994-06-16 1995-12-20 Roche Diagnostics GmbH Magnetic separation method for components of a liquid
WO1996012958A1 (en) * 1994-10-20 1996-05-02 Labsystems Oy Separation device for microparticles involving a magnetic rod
WO1996012961A1 (en) * 1994-10-20 1996-05-02 Labsystems Oy Two-stage separation method
WO1996012960A1 (en) * 1994-10-20 1996-05-02 Labsystems Oy Separation of magnetic microparticles involving a pre-concentration step
WO1996012959A1 (en) * 1994-10-20 1996-05-02 Labsystems Oy Magnetic particle transfer device
NL1001427C2 (en) * 1995-10-16 1997-04-17 Paulus Wolfs Device for removing magnetizable parts.
US5837144A (en) * 1994-06-16 1998-11-17 Boehringer Mannheim Gmbh Method of magnetically separating liquid components
WO1999004239A2 (en) * 1997-07-16 1999-01-28 Heermann Klaus Hinrich Magnetic pin for concentrating and separating particles
WO1999040444A1 (en) * 1998-02-06 1999-08-12 Bio-Magnetics Ltd. A device and system for transfer of material
WO1999042832A1 (en) * 1998-02-23 1999-08-26 Bio-Nobile Oy Magnetic particle transfer device and method
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JP2004229657A (en) * 2003-01-29 2004-08-19 Bionex Inc Kit for separating and purifying nucleic acid or various biological materials, and system for automated operation of the same
WO2005037440A1 (en) * 2003-10-20 2005-04-28 Bio-Nobile Oy Magnetic enrichment method, a reactor unit for micro particles and a magnet unit
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JP2010506172A (en) * 2006-10-06 2010-02-25 プロメガ・コーポレーション Apparatus and method for separating magnetic particles from solution
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US6409925B1 (en) * 1998-02-06 2002-06-25 Bio-Magnetics Ltd. Device and system for transfer of material
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US6468810B1 (en) 1998-02-23 2002-10-22 Bio-Nobile Oy Magnetic particle transfer device and method
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US6596162B2 (en) 2000-03-14 2003-07-22 Thermo Labsystems Oy Vessel and rod
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