WO1990002960A1 - An apparatus for monitoring the radioactivity of a plurality of liquid scintillation samples deposited on multi-well sample plates - Google Patents

An apparatus for monitoring the radioactivity of a plurality of liquid scintillation samples deposited on multi-well sample plates Download PDF

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Publication number
WO1990002960A1
WO1990002960A1 PCT/SE1989/000464 SE8900464W WO9002960A1 WO 1990002960 A1 WO1990002960 A1 WO 1990002960A1 SE 8900464 W SE8900464 W SE 8900464W WO 9002960 A1 WO9002960 A1 WO 9002960A1
Authority
WO
WIPO (PCT)
Prior art keywords
sample
photomultiplier tube
light pipe
sample plate
wells
Prior art date
Application number
PCT/SE1989/000464
Other languages
French (fr)
Inventor
Tapio YRJÖNEN
Kauko Lehtinen
Vesa Sonne
Original Assignee
Wallac Oy
Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wallac Oy, Pharmacia Ab filed Critical Wallac Oy
Priority to DE1989603564 priority Critical patent/DE68903564T2/en
Priority to AT89909887T priority patent/ATE82642T1/en
Publication of WO1990002960A1 publication Critical patent/WO1990002960A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
    • G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
    • G01T1/16—Measuring radiation intensity
    • G01T1/20—Measuring radiation intensity with scintillation detectors
    • G01T1/204—Measuring radiation intensity with scintillation detectors the detector being a liquid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
    • G01T7/00—Details of radiation-measuring instruments

Definitions

  • Multi-well sample plates which comprise several separate sample wells are widely used as test plates for in vitro analysis.
  • Said plates can be produced for example by vacuum thermoforming (deep drawing) from a transparent plastic sheet and they have for example eight rows of wells arranged in twelve columns.
  • These plates can be used especially for preparing typically low energy beta radiation emitting liquid scintillation samples.
  • these samples must first be transferred into liquid scintillation counting vials, because existing liquid scintillation counters cannot count samples directly from this kind of multi-well sample plates.
  • the present invention shows a new apparatus which counts one or several liquid scintillation or corresponding samples at a time directly from the multi-well sample plates which comprise several separate sample wells.
  • Figures la and lb show a vertical section of the counting conditions of the apparatus. DESCRIPTION OF THE PREFERRED EMBODIMENTS
  • a sample plate (10), which has several sample wells (11) is placed manually or automatically in a position, where a liquid scintillation sample (16), which is in the sample well (11), can be counted.
  • the apparatus has one or several detectors, built of two photomultiplier tube assemblies (14 a, 14 b) which work in coincidence and are situated on the opposite sides of said sample plate (10) .
  • the lower photomultiplier tube assembly (14 a) is provided with a light pipe (12).
  • the inner diameter of this light pipe (12) is equal to or larger than the maximum outer diameter of the sample wells (11).
  • the apparatus has a moving mechanism, which is not shown here, by which said lower photomultiplier tube assembly (14 a) provided with said light pipe (12) can be moved to up or down positions.
  • the inner surfaces (17) of said light pipe (12) reflects or scatters light.
  • one or both of the surfaces (18) between the wells (11) of the sample plate (10) are painted black or this region (18) is treated in some other way which prevents light from travelling between the sample wells (11) inside the material of the sample plate (10).

Abstract

The present invention shows a new apparatus in the field of the liquid scintillation counting. The apparatus counts liquid scintillation or corresponding samples directly from the sample plates (10) which comprise several separate sample wells (11) or vials. The apparatus has one or several detectors for the purpose of counting one or several samples at a time. The sample plate (10) is placed manually or automatically between photomultiplier tube assembly pair (14 a, 14 b) which works in coincidence forming the detector of the apparatus. The lower photomultiplier tube assembly (14 a) is provided with a light pipe (12). The apparatus has a moving mechanism, which can move the lower photomultiplier tube assembly (14 a) with said light pipe to up and down positions. In the up position the walls of the light pipe (12) are pressed tightly against said upper photomultiplier tube assembly (14 a) in order to form an optically closed compartment around the sample well (11) which is in the counting position. In order to prevent light from travelling between the sample wells (11) through the material of the sample plate (10) one or both surfaces between the wells (18) of the sample plate (10) are painted black or this region (18) is treated in some other way which prevents light from travelling between the sample wells (11).

Description

AN APPARATUS FOR MONITORING THE RADIOACTIVITY OF A PLURALITY OF LIQUID SCINTILLATION SAMPLES DEPOSITED ON MULTI-WELL SAMPLE PLATES
BACKGROUND OF THE INVENTION
Multi-well sample plates which comprise several separate sample wells are widely used as test plates for in vitro analysis. Said plates can be produced for example by vacuum thermoforming (deep drawing) from a transparent plastic sheet and they have for example eight rows of wells arranged in twelve columns. These plates can be used especially for preparing typically low energy beta radiation emitting liquid scintillation samples. Unfortunately, these samples must first be transferred into liquid scintillation counting vials, because existing liquid scintillation counters cannot count samples directly from this kind of multi-well sample plates.
SUMMARY OF THE INVENTION
The present invention shows a new apparatus which counts one or several liquid scintillation or corresponding samples at a time directly from the multi-well sample plates which comprise several separate sample wells.
BRIEF DESCRIPTION OF THE DRAWINGS
Figures la and lb show a vertical section of the counting conditions of the apparatus. DESCRIPTION OF THE PREFERRED EMBODIMENTS
In Figure la a sample plate (10), which has several sample wells (11) is placed manually or automatically in a position, where a liquid scintillation sample (16), which is in the sample well (11), can be counted.In order to count one or several samples (16), which are in said sample wells (11), at a time, the apparatus has one or several detectors, built of two photomultiplier tube assemblies (14 a, 14 b) which work in coincidence and are situated on the opposite sides of said sample plate (10) .
The lower photomultiplier tube assembly (14 a) is provided with a light pipe (12). The inner diameter of this light pipe (12) is equal to or larger than the maximum outer diameter of the sample wells (11).
The apparatus has a moving mechanism, which is not shown here, by which said lower photomultiplier tube assembly (14 a) provided with said light pipe (12) can be moved to up or down positions.
In Figure la said lower photomultiplier tube assembly (14 a) provided with said light pipe (12) is in down position in order to allow free horizontal movement of said sample plate (10). In Figure lb said lower photomultiplier tube assembly (14 a) provided with said light pipe (12) has been lifted to the up position tightly against said upper photomultiplier tube assembly (14b) in order to form an optically closed compartment around said sample well (11) of the sample plate (10).
In order to guide the light from the liquid scintillation samples (16) located in said sample wells (11) to said photomultiplier tubes (14 a, 14 b), the inner surfaces (17) of said light pipe (12) reflects or scatters light.
In order to prevent light from travelling between the sample wells (11) inside the material of the sample plate (10), one or both of the surfaces (18) between the wells (11) of the sample plate (10) are painted black or this region (18) is treated in some other way which prevents light from travelling between the sample wells (11) inside the material of the sample plate (10).
The invention is not confined to the above embodiments alone, but it may show even considerable variation within the scope of the patent claims.

Claims

WHAT IS CLAIMED IS:
1. Apparatus for counting liquid scintillation samples fro sample plates which comprise several separate sample wells o vials, characterized in that,
- the sample plate is placed manually or automatically in the counting position between two photomultiplier tube assemblies which form the detector of the apparatus and which work i coincidence and are situated exactly on the opposite sides o that well of the sample plate which in that time will be counted.
- the lower photomultiplier tube assembly is provided with light pipe whose inner diameter is equal to or larger than th maximum diameter of the sample wells of the sample plate.
- the lower photomultiplier tube with the light pipe can be move in two positions: in the up position, the walls of the ligh pipe are pressed tightly against said upper photomultiplier tub assembly in order to form an optically closed compartment aroun said sample well which is in the counting position. The dow position of said lower photomultiplier tube assembly with sai light pipe allows free movement of said sample plate in orde to make it possible to move the next sample well to the countin position.
- the inner surface of said light pipe is reflecting o scattering in order to guide the light from the liqui scintillation sample to the said photomultiplier tube pair.
- the apparatus has one or several detectors in order to coun one or several samples at a time.
2. Apparatus according to claim 1, characterized in that that on or both surfaces of said sample plate between said sample well are painted black or said regions are treated in some other wa to prevent light from travelling between said sample wells insid the material of said sample plate.
PCT/SE1989/000464 1988-09-06 1989-09-04 An apparatus for monitoring the radioactivity of a plurality of liquid scintillation samples deposited on multi-well sample plates WO1990002960A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE1989603564 DE68903564T2 (en) 1988-09-06 1989-09-04 DEVICE FOR DETERMINING THE RADIOACTIVITY OF A VARIETY OF LIQUID SCINTILLATION SAMPLES APPLIED ON MULTIPLE PATTERN PLATES.
AT89909887T ATE82642T1 (en) 1988-09-06 1989-09-04 DEVICE FOR DETERMINING THE RADIOACTIVITY OF A VARIETY OF LIQUID SCINTILLATION SAMPLES PLACED ON MULTIPLE SAMPLE PLATES.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8803115-8 1988-09-06
SE8803115A SE8803115D0 (en) 1988-09-06 1988-09-06 APPARATUS FOR MONITORING THE RADIOACTIVITY OF A PLURALITY OF LIQUID SCINTILLATION SAMPLES DEPOSITED ON MULTI-WELL SAMPLE PLATES

Publications (1)

Publication Number Publication Date
WO1990002960A1 true WO1990002960A1 (en) 1990-03-22

Family

ID=20373229

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE1989/000464 WO1990002960A1 (en) 1988-09-06 1989-09-04 An apparatus for monitoring the radioactivity of a plurality of liquid scintillation samples deposited on multi-well sample plates

Country Status (5)

Country Link
US (1) US5039860A (en)
EP (1) EP0396657B1 (en)
JP (1) JPH03501057A (en)
SE (1) SE8803115D0 (en)
WO (1) WO1990002960A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2261946A (en) * 1991-11-08 1993-06-02 Wallac Oy Liquid scintillation counter

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI86344C (en) * 1988-12-02 1992-08-10 Wallac Oy FOERFARANDE FOER RAETTANDE AV MAETNINGSFEL ORSAKAT AV AENDRING AV PROVVOLYM I VAETSKESCINTILLATIONSRAEKNARE OCH VAETSKESCINTILLATIONSRAEKNARE.
US5380493A (en) * 1992-03-27 1995-01-10 Chavez; Jeffery B. Cell well plate holder and well marking system
US5329123A (en) * 1992-09-23 1994-07-12 Wallac Oy Method and a device for preventing optical crosstalk between liquid scintillation samples deposited on transculcent sample plates
US5856194A (en) 1996-09-19 1999-01-05 Abbott Laboratories Method for determination of item of interest in a sample
US5795784A (en) 1996-09-19 1998-08-18 Abbott Laboratories Method of performing a process for determining an item of interest in a sample
GB2319836B (en) * 1996-11-25 2001-04-04 Porvair Plc Microplates
US20050287347A1 (en) * 2003-06-02 2005-12-29 Pavilion Furniture, Inc. Polyurethane and rigid substrate composite with fasteners

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4298796A (en) * 1976-09-24 1981-11-03 Warner Gerald T Method of, and apparatus for, monitoring radioactivity
WO1982000359A1 (en) * 1980-07-24 1982-02-04 Oy Labsystems Set of cuvettes
GB2167279A (en) * 1984-11-15 1986-05-21 Ian Redmayne Radiation imaging

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3924128A (en) * 1972-06-05 1975-12-02 Packard Instrument Co Inc Apparatus for handling flexible containers for liquid sample spectrometry

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4298796A (en) * 1976-09-24 1981-11-03 Warner Gerald T Method of, and apparatus for, monitoring radioactivity
WO1982000359A1 (en) * 1980-07-24 1982-02-04 Oy Labsystems Set of cuvettes
GB2167279A (en) * 1984-11-15 1986-05-21 Ian Redmayne Radiation imaging

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2261946A (en) * 1991-11-08 1993-06-02 Wallac Oy Liquid scintillation counter

Also Published As

Publication number Publication date
EP0396657A1 (en) 1990-11-14
JPH03501057A (en) 1991-03-07
EP0396657B1 (en) 1992-11-19
US5039860A (en) 1991-08-13
SE8803115D0 (en) 1988-09-06

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