WO1990014090A1 - SHORT THERAPEUTIC dsRNA OF DEFINED STRUCTURE - Google Patents
SHORT THERAPEUTIC dsRNA OF DEFINED STRUCTURE Download PDFInfo
- Publication number
- WO1990014090A1 WO1990014090A1 PCT/US1989/002172 US8902172W WO9014090A1 WO 1990014090 A1 WO1990014090 A1 WO 1990014090A1 US 8902172 W US8902172 W US 8902172W WO 9014090 A1 WO9014090 A1 WO 9014090A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- dsrna
- human
- therapeutically
- short
- therapy
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1989/002172 WO1990014090A1 (en) | 1989-05-19 | 1989-05-19 | SHORT THERAPEUTIC dsRNA OF DEFINED STRUCTURE |
JP1503637A JPH04507083A (en) | 1989-05-19 | 1989-05-19 | Short therapeutic dsRNA of defined structure |
EP19890906635 EP0473576A4 (en) | 1989-05-19 | 1989-05-19 | Short therapeutic dsrna of defined structure |
DK911889A DK188991D0 (en) | 1989-05-19 | 1991-11-19 | THERAPEUTIC EFFECTIVE SHORT, DOUBLE-STRENGTH RNA |
NO91914529A NO914529L (en) | 1989-05-19 | 1991-11-19 | BRIEF THERAPEUTIC DSRNA WITH DEFINED STRUCTURE |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1989/002172 WO1990014090A1 (en) | 1989-05-19 | 1989-05-19 | SHORT THERAPEUTIC dsRNA OF DEFINED STRUCTURE |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1990014090A1 true WO1990014090A1 (en) | 1990-11-29 |
Family
ID=22215026
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1989/002172 WO1990014090A1 (en) | 1989-05-19 | 1989-05-19 | SHORT THERAPEUTIC dsRNA OF DEFINED STRUCTURE |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0473576A4 (en) |
JP (1) | JPH04507083A (en) |
DK (1) | DK188991D0 (en) |
NO (1) | NO914529L (en) |
WO (1) | WO1990014090A1 (en) |
Cited By (65)
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WO1993012229A1 (en) * | 1991-12-18 | 1993-06-24 | Cis Bio International | Method for preparing double stranded rna, and use thereof |
WO2000001846A2 (en) * | 1998-07-03 | 2000-01-13 | Devgen N.V. | Characterisation of gene function using double stranded rna inhibition |
WO2000068374A1 (en) * | 1999-05-10 | 2000-11-16 | Syngenta Participations Ag | Regulation of viral gene expression |
WO2003070918A3 (en) * | 2002-02-20 | 2004-07-08 | Ribozyme Pharm Inc | Rna interference by modified short interfering nucleic acid |
GB2397818A (en) * | 2002-02-20 | 2004-08-04 | Sirna Therapeutics Inc | Rna interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid |
NL1026335C2 (en) * | 2004-06-04 | 2005-12-06 | Univ Delft Tech | Method for making a double-stranded polyribonucleotide sequence with overhanging end, as well as a method for forming a double-stranded polynucleotide construct and an application. |
US7005423B1 (en) | 1999-07-02 | 2006-02-28 | Devgen Nv | Characterization of gene function using double stranded RNA inhibition |
US7022828B2 (en) | 2001-04-05 | 2006-04-04 | Sirna Theraputics, Inc. | siRNA treatment of diseases or conditions related to levels of IKK-gamma |
US7176304B2 (en) | 2002-02-20 | 2007-02-13 | Mcswiggen James | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
US7491805B2 (en) | 2001-05-18 | 2009-02-17 | Sirna Therapeutics, Inc. | Conjugates and compositions for cellular delivery |
US7560438B2 (en) | 1997-12-23 | 2009-07-14 | The Carnegie Institution Of Washington | Genetic inhibition by double-stranded RNA |
US7659389B2 (en) | 2001-05-18 | 2010-02-09 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of MYC and/or MYB gene expression using short interfering nucleic acid (siNA) |
US7659390B2 (en) | 2002-02-20 | 2010-02-09 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of muscarinic colinergic receptor gene expression using short interfering nucleic acid (siNA) |
US7662951B2 (en) | 2000-08-30 | 2010-02-16 | Sirna Therapeutics, Inc. | RNA interference mediated treatment of Alzheimer's disease using short interfering nucleic acid (siNA) |
US7662952B2 (en) | 2002-02-20 | 2010-02-16 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of GRB2 associated binding protein (GAB2) gene expression using short interfering nucleic acid (siNA) |
US7667030B2 (en) | 2002-02-20 | 2010-02-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of matrix metalloproteinase 13 (MMP13) gene expression using short interfering nucleic acid (siNA) |
US7667029B2 (en) | 2002-02-20 | 2010-02-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of checkpoint kinase-1 (CHK-1) gene expression using short interfering nucleic acid (siNA) |
US7678897B2 (en) | 2002-02-20 | 2010-03-16 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of platelet-derived endothelial cell growth factor (ECGF1) gene expression using short interfering nucleic acid (siNA) |
US7691999B2 (en) | 2002-02-20 | 2010-04-06 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of NOGO and NOGO receptor gene expression using short interfering nucleic acid (siNA) |
US7700760B2 (en) | 2002-02-20 | 2010-04-20 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of vascular cell adhesion molecule (VCAM) gene expression using short interfering nucleic acid (siNA) |
US7744900B2 (en) | 1999-04-08 | 2010-06-29 | Novartis Vaccines And Diagnostics, Inc. | Enhancement of the immune response for vaccine and gene therapy applications |
US7795422B2 (en) | 2002-02-20 | 2010-09-14 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of hypoxia inducible factor 1 (HIF1) gene expression using short interfering nucleic acid (siNA) |
US7833992B2 (en) | 2001-05-18 | 2010-11-16 | Merck Sharpe & Dohme | Conjugates and compositions for cellular delivery |
US7858769B2 (en) | 2004-02-10 | 2010-12-28 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using multifunctional short interfering nucleic acid (multifunctional siNA) |
US7858625B2 (en) | 2001-05-18 | 2010-12-28 | Sirna Therapeutics, Inc. | Conjugates and compositions for cellular delivery |
US7888325B2 (en) | 1999-01-28 | 2011-02-15 | Medical College Of Georgia Research Institute, Inc. | Composition and method for in vivo and in vitro attenuation of gene expression using double stranded RNA |
US7893248B2 (en) | 2002-02-20 | 2011-02-22 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of Myc and/or Myb gene expression using short interfering nucleic acid (siNA) |
US7897752B2 (en) | 2002-02-20 | 2011-03-01 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of telomerase gene expression using short interfering nucleic acid (siNA) |
US7897757B2 (en) | 2002-02-20 | 2011-03-01 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA) |
US7897753B2 (en) | 2002-02-20 | 2011-03-01 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of XIAP gene expression using short interfering nucleic acid (siNA) |
US7910725B2 (en) | 2002-02-20 | 2011-03-22 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (siNA) |
US7910724B2 (en) | 2002-02-20 | 2011-03-22 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of Fos gene expression using short interfering nucleic acid (siNA) |
US7915400B2 (en) | 2002-02-20 | 2011-03-29 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of hepatitis C virus (HCV) gene expression using short interfering nucleic acid (siNA) |
US7923547B2 (en) | 2002-09-05 | 2011-04-12 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US7923549B2 (en) | 2002-02-20 | 2011-04-12 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (siNA) |
US7928218B2 (en) | 2002-02-20 | 2011-04-19 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of polycomb group protein EZH2 gene expression using short interfering nucleic acid (siNA) |
US7928220B2 (en) | 2002-02-20 | 2011-04-19 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of stromal cell-derived factor-1 (SDF-1) gene expression using short interfering nucleic acid (siNA) |
US7928219B2 (en) | 2002-02-20 | 2011-04-19 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of placental growth factor gene expression using short interfering nucleic acid (SINA) |
US7935812B2 (en) | 2002-02-20 | 2011-05-03 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of hepatitis C virus (HCV) expression using short interfering nucleic acid (siNA) |
US7943757B2 (en) | 2002-02-20 | 2011-05-17 | Mcswiggen James | RNA interference mediated inhibition of intercellular adhesion molecule (ICAM) gene expression using short interfering nucleic acid (siNA) |
US7977472B2 (en) | 2002-02-20 | 2011-07-12 | Leonid Beigelman | RNA interference mediated inhibition of myostatin gene expression using short interfering nucleic acid (siNA) |
US7985853B2 (en) | 2002-02-20 | 2011-07-26 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of platelet derived growth factor (PDGF) and platelet derived growth factor receptor (PDGFR) gene expression using short interfering nucleic acid (siNA) |
US7989612B2 (en) | 2002-02-20 | 2011-08-02 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US8008473B2 (en) | 2002-02-20 | 2011-08-30 | Mcswiggen James | RNA interference mediated inhibition of TNF and TNF receptor gene expression using short interfering nucleic acid (siNA) |
US8008472B2 (en) | 2001-05-29 | 2011-08-30 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of human immunodeficiency virus (HIV) gene expression using short interfering nucleic acid (siNA) |
US8013143B2 (en) | 2002-02-20 | 2011-09-06 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of CXCR4 gene expression using short interfering nucleic acid (siNA) |
US8017761B2 (en) | 2001-05-18 | 2011-09-13 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of Stearoyl-CoA desaturase (SCD) gene expression using short interfering nucelic acid (siNA) |
US8053419B2 (en) | 1998-03-20 | 2011-11-08 | Commonwealth Scientific And Industrial Research Organisation | Synthetic genes and genetic constructs |
US8067575B2 (en) | 2002-02-20 | 2011-11-29 | Merck, Sharp & Dohme Corp. | RNA interference mediated inhibition of cyclin D1 gene expression using short interfering nucleic acid (siNA) |
US8148604B2 (en) | 2004-10-21 | 2012-04-03 | Venganza Inc. | Methods and materials for conferring resistance to pests and pathogens of plants |
US8168774B2 (en) | 1998-03-20 | 2012-05-01 | Commonwealth Scientific And Industrial Research Organisation | Control of gene expression |
US8183217B2 (en) | 1999-08-13 | 2012-05-22 | Commonwealth Scientific And Industrial Research Organisation | Methods and means for obtaining modified phenotypes |
US8258288B2 (en) | 2002-02-20 | 2012-09-04 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of respiratory syncytial virus (RSV) expression using short interfering nucleic acid (siNA) |
US8273866B2 (en) | 2002-02-20 | 2012-09-25 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA) |
US8329890B2 (en) | 2002-08-05 | 2012-12-11 | University Of Iowa Research Foundation | SiRNA-mediated gene silencing |
US8481710B2 (en) | 2002-08-05 | 2013-07-09 | University Of Iowa Research Foundation | RNA interference suppression of neurodegenerative diseases and methods of use thereof |
US8524879B2 (en) | 2002-08-05 | 2013-09-03 | University Of Iowa Research Foundation | RNA interference suppresion of neurodegenerative diseases and methods of use thereof |
US8598332B1 (en) | 1998-04-08 | 2013-12-03 | Bayer Cropscience N.V. | Methods and means for obtaining modified phenotypes |
US9051566B2 (en) | 2001-01-31 | 2015-06-09 | Alnylam Pharmaceuticals, Inc. | Post-transcriptional gene silencing using expressed double stranded RNA |
US9181551B2 (en) | 2002-02-20 | 2015-11-10 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US9260471B2 (en) | 2010-10-29 | 2016-02-16 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA) |
US9441239B2 (en) | 1998-04-08 | 2016-09-13 | Commonwealth Scientific & Industrial Research Organisation | Methods and means for obtaining modified phenotypes |
US9657294B2 (en) | 2002-02-20 | 2017-05-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US9994853B2 (en) | 2001-05-18 | 2018-06-12 | Sirna Therapeutics, Inc. | Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference |
US10508277B2 (en) | 2004-05-24 | 2019-12-17 | Sirna Therapeutics, Inc. | Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference |
Citations (15)
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US3444043A (en) * | 1966-09-30 | 1969-05-13 | Univ Illinois | Interference with biologically active rna formation |
US3660564A (en) * | 1968-12-24 | 1972-05-02 | Takeda Chemical Industries Ltd | Interferon induction |
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-
1989
- 1989-05-19 JP JP1503637A patent/JPH04507083A/en active Pending
- 1989-05-19 EP EP19890906635 patent/EP0473576A4/en not_active Ceased
- 1989-05-19 WO PCT/US1989/002172 patent/WO1990014090A1/en not_active Application Discontinuation
-
1991
- 1991-11-19 DK DK911889A patent/DK188991D0/en not_active Application Discontinuation
- 1991-11-19 NO NO91914529A patent/NO914529L/en unknown
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US3660564A (en) * | 1968-12-24 | 1972-05-02 | Takeda Chemical Industries Ltd | Interferon induction |
US4124702A (en) * | 1971-07-06 | 1978-11-07 | Merck & Co., Inc. | Polynucleotides active as inducers of interferon production in living animal cells |
US3819482A (en) * | 1972-05-08 | 1974-06-25 | J Semancik | Method of preparing high yields of double-stranded ribonucleic acid |
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US4130641A (en) * | 1973-10-30 | 1978-12-19 | Ts O Paul O P | Induction of interferon production by modified nucleic acid complexes |
US4024241A (en) * | 1974-09-27 | 1977-05-17 | The United States Of America As Represented By The Secretary Of Health, Education And Welfare | Nuclease-resistant hydrophilic complex of polyriboinosinic-polyribocytidylic acid |
US4018916A (en) * | 1975-01-27 | 1977-04-19 | Beecham Group Limited | Antiviral ionic complexes of double-standard RNA |
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Non-Patent Citations (10)
Cited By (120)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2685346A1 (en) * | 1991-12-18 | 1993-06-25 | Cis Bio Int | PROCESS FOR THE PREPARATION OF DOUBLE-STRANDED RNA AND ITS APPLICATIONS |
US5795715A (en) * | 1991-12-18 | 1998-08-18 | Cis Bio International | Process for preparing double-stranded RNA, and its applications |
WO1993012229A1 (en) * | 1991-12-18 | 1993-06-24 | Cis Bio International | Method for preparing double stranded rna, and use thereof |
US7622633B2 (en) | 1997-12-23 | 2009-11-24 | Carnegie Institution Of Washington | Genetic inhibition by double-stranded RNA |
US7560438B2 (en) | 1997-12-23 | 2009-07-14 | The Carnegie Institution Of Washington | Genetic inhibition by double-stranded RNA |
US9102939B2 (en) | 1997-12-23 | 2015-08-11 | The Carnegie Institution Of Washington | Genetic inhibition by double-stranded RNA |
US8053419B2 (en) | 1998-03-20 | 2011-11-08 | Commonwealth Scientific And Industrial Research Organisation | Synthetic genes and genetic constructs |
US9029527B2 (en) | 1998-03-20 | 2015-05-12 | Commonwealth Scientific And Industrial Research Organisation | Synthetic genes and genetic constructs |
US8168774B2 (en) | 1998-03-20 | 2012-05-01 | Commonwealth Scientific And Industrial Research Organisation | Control of gene expression |
US9963698B2 (en) | 1998-03-20 | 2018-05-08 | Commonwealth Scientific And Industrial Research Organisation | Control of gene expression |
US8598332B1 (en) | 1998-04-08 | 2013-12-03 | Bayer Cropscience N.V. | Methods and means for obtaining modified phenotypes |
US9441239B2 (en) | 1998-04-08 | 2016-09-13 | Commonwealth Scientific & Industrial Research Organisation | Methods and means for obtaining modified phenotypes |
GB2362885A (en) * | 1998-07-03 | 2001-12-05 | Devgen Nv | Characterisation of gene function using double stranded (ds) RNA inhibition |
GB2362885B (en) * | 1998-07-03 | 2002-07-31 | Devgen Nv | Expression vector capable of producing double stranded RNA inhibition |
GB2349885B (en) * | 1998-07-03 | 2003-01-29 | Devgen Nv | Characterisation of gene function using double stranded RNA inhibition |
US8114980B2 (en) | 1998-07-03 | 2012-02-14 | Devgen Nv | Characterisation of gene function using double stranded RNA inhibition |
EP1197567A3 (en) * | 1998-07-03 | 2003-01-02 | Devgen NV | Characterisation of gene function using double stranded RNA inhibition |
WO2000001846A2 (en) * | 1998-07-03 | 2000-01-13 | Devgen N.V. | Characterisation of gene function using double stranded rna inhibition |
CZ304897B6 (en) * | 1998-07-03 | 2015-01-07 | Devgen N. V. | Method of delivering double-stranded RNA or DNA capable of producing double-stranded RNA and non-therapeutic use of bacterial or yeas cell |
GB2349885A (en) * | 1998-07-03 | 2000-11-15 | Devgen Nv | Characterisation of gene function using double stranded RNA inhibition |
WO2000001846A3 (en) * | 1998-07-03 | 2000-06-15 | Devgen Nv | Characterisation of gene function using double stranded rna inhibition |
EP1197567A2 (en) | 1998-07-03 | 2002-04-17 | Devgen NV | Characterisation of gene function using double stranded RNA inhibition |
EP2045336A3 (en) * | 1998-07-03 | 2009-06-10 | Devgen NV | Characterisation of gene function using double stranded RNA inhibition |
JP2009112311A (en) * | 1998-07-03 | 2009-05-28 | Devgen Nv | Evaluation of gene function by using double-stranded rna inhibition |
US8148345B2 (en) | 1999-01-28 | 2012-04-03 | Georgia Health Sciences University Research Institute, Inc. | Composition and method for in vivo and in vitro attenuation of gene expression using double stranded RNA |
US7888325B2 (en) | 1999-01-28 | 2011-02-15 | Medical College Of Georgia Research Institute, Inc. | Composition and method for in vivo and in vitro attenuation of gene expression using double stranded RNA |
US7744900B2 (en) | 1999-04-08 | 2010-06-29 | Novartis Vaccines And Diagnostics, Inc. | Enhancement of the immune response for vaccine and gene therapy applications |
EP1801215A3 (en) * | 1999-05-10 | 2008-12-17 | Syngeta Participations AG | Regulation of viral gene expression |
WO2000068374A1 (en) * | 1999-05-10 | 2000-11-16 | Syngenta Participations Ag | Regulation of viral gene expression |
EP1801215A2 (en) * | 1999-05-10 | 2007-06-27 | Syngeta Participations AG | Regulation of viral gene expression |
US7005423B1 (en) | 1999-07-02 | 2006-02-28 | Devgen Nv | Characterization of gene function using double stranded RNA inhibition |
US8183217B2 (en) | 1999-08-13 | 2012-05-22 | Commonwealth Scientific And Industrial Research Organisation | Methods and means for obtaining modified phenotypes |
US10190127B2 (en) | 1999-08-13 | 2019-01-29 | Commonwealth Scientific And Industrial Research Organisation | Methods and means for obtaining modified phenotypes |
US9708621B2 (en) | 1999-08-13 | 2017-07-18 | Commonwealth Scientific And Industrial Research Organisation | Methods and means for obtaining modified phenotypes |
US7662951B2 (en) | 2000-08-30 | 2010-02-16 | Sirna Therapeutics, Inc. | RNA interference mediated treatment of Alzheimer's disease using short interfering nucleic acid (siNA) |
US8017765B2 (en) | 2000-08-30 | 2011-09-13 | Merck Sharp & Dohme Corp. | RNA interference mediated treatment of alzheimer's disease using short interfering nucleic acid (siNA) |
US9051566B2 (en) | 2001-01-31 | 2015-06-09 | Alnylam Pharmaceuticals, Inc. | Post-transcriptional gene silencing using expressed double stranded RNA |
US7022828B2 (en) | 2001-04-05 | 2006-04-04 | Sirna Theraputics, Inc. | siRNA treatment of diseases or conditions related to levels of IKK-gamma |
US7833992B2 (en) | 2001-05-18 | 2010-11-16 | Merck Sharpe & Dohme | Conjugates and compositions for cellular delivery |
US9994853B2 (en) | 2001-05-18 | 2018-06-12 | Sirna Therapeutics, Inc. | Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference |
US8017761B2 (en) | 2001-05-18 | 2011-09-13 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of Stearoyl-CoA desaturase (SCD) gene expression using short interfering nucelic acid (siNA) |
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Also Published As
Publication number | Publication date |
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JPH04507083A (en) | 1992-12-10 |
EP0473576A1 (en) | 1992-03-11 |
EP0473576A4 (en) | 1993-03-10 |
DK188991D0 (en) | 1991-11-19 |
NO914529D0 (en) | 1991-11-19 |
NO914529L (en) | 1992-04-14 |
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