WO1990015066A3 - Sequences nucleotidiques issues du genome des retrovirus du type hiv-1, hiv-2 et siv, et leurs applications notamment pour l'amplification des genomes de ces retrovirus et pour le diagnostic in vitro des infections dues a ces virus - Google Patents

Sequences nucleotidiques issues du genome des retrovirus du type hiv-1, hiv-2 et siv, et leurs applications notamment pour l'amplification des genomes de ces retrovirus et pour le diagnostic in vitro des infections dues a ces virus Download PDF

Info

Publication number
WO1990015066A3
WO1990015066A3 PCT/FR1990/000393 FR9000393W WO9015066A3 WO 1990015066 A3 WO1990015066 A3 WO 1990015066A3 FR 9000393 W FR9000393 W FR 9000393W WO 9015066 A3 WO9015066 A3 WO 9015066A3
Authority
WO
WIPO (PCT)
Prior art keywords
hiv
genomes
applications
gemone
retroviruses
Prior art date
Application number
PCT/FR1990/000393
Other languages
English (en)
Other versions
WO1990015066A2 (fr
Inventor
Maurice Moncany
Luc Montagnier
Original Assignee
Pasteur Institut
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8907354A external-priority patent/FR2647809B1/fr
Priority claimed from FR8912371A external-priority patent/FR2652091B1/fr
Application filed by Pasteur Institut, Inst Nat Sante Rech Med filed Critical Pasteur Institut
Priority to CA002062829A priority Critical patent/CA2062829C/fr
Priority to DK05014676T priority patent/DK1642987T3/da
Publication of WO1990015066A2 publication Critical patent/WO1990015066A2/fr
Publication of WO1990015066A3 publication Critical patent/WO1990015066A3/fr
Priority to US08/895,231 priority patent/US5786177A/en
Priority to US09/092,077 priority patent/US6194142B1/en
Priority to US10/862,363 priority patent/US7759477B2/en
Priority to US11/203,127 priority patent/US7777020B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
    • G01N2333/155—Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
    • G01N2333/16—HIV-1, HIV-2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/974—Aids related test
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Abstract

La présente invention concerne des séquences nucléotidiques dérivées des génomes des virus du type HIV-1, ou des génomes des virus du type HIV-2, ou des virus du type SIV, et leurs applications, notamment en tant qu'amorces oligonucléotidiques pour la mise en ÷uvre de méthode de diagnostic in vitro de l'infection d'un individu par un virus du type HIV-1 et/ou HIV-2.
PCT/FR1990/000393 1989-06-02 1990-06-05 Sequences nucleotidiques issues du genome des retrovirus du type hiv-1, hiv-2 et siv, et leurs applications notamment pour l'amplification des genomes de ces retrovirus et pour le diagnostic in vitro des infections dues a ces virus WO1990015066A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002062829A CA2062829C (fr) 1989-06-02 1990-06-05 Sequences nucleotidiques issues du genome des retrovirus du type hiv-1, hiv-2 et siv, et leurs applications notamment pour l'amplification des genomes de ces retrovirus et pour lediagnostic in vitro des infections dues a ces virus
DK05014676T DK1642987T3 (da) 1989-06-02 1990-06-05 Nucleotidsekvenser dannet ud fra genomerne af retrovirusserne HIV-1, HIV-2 og SIV samt deres anvendelse til opformering af disse virale genomer samt til en vitro-diagnose af infektioner, der stammer fra disse virusser
US08/895,231 US5786177A (en) 1989-06-02 1997-07-16 Nucleotide sequences derived from the genome or retroviruses of the HIV-1, HIV-2, and SIV type, and their uses in particular for the amplification of the genomes of these retroviruses and for the in vitro diagnosis of the diseases due to these viruses
US09/092,077 US6194142B1 (en) 1989-06-02 1998-06-05 Nucleotide sequences derived from the genome of retroviruses of the HIV-1, HIV-2, and SIV type, and their uses in particular for the amplification of the genomes of these retroviruses and for the in vitro diagnosis of the diseases due to these viruses
US10/862,363 US7759477B2 (en) 1989-06-02 2004-06-08 HIV-1, HIV-2, and SIV pol nucleotide fragments
US11/203,127 US7777020B2 (en) 1989-06-02 2005-08-15 Nucleotide sequences derived from the env gene of HIV-1

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR89/07354 1989-06-02
FR8907354A FR2647809B1 (fr) 1989-06-02 1989-06-02 Amorces oligonucleotidiques pour l'amplification du genome des retrovirus du type hiv-1, hiv-2 et siv, et leurs applications au diagnostic in vitro des infections dues a ces virus
FR89/12371 1989-09-20
FR8912371A FR2652091B1 (fr) 1989-09-20 1989-09-20 Sequences nucleotidiques issues du genome des retrovirus du type hiv-1, hiv-2 et siv, et leurs applications notamment pour l'amplification des genomes de ces retrovirus et pour le diagnostic in-vitro des infections dues a ces virus.

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US07820599 A-371-Of-International 1990-06-05
US08/160,465 Continuation US5688637A (en) 1989-06-02 1993-12-02 Nucleotide sequences derived from the genome of retroviruses of the HIV-1, HIV-2 and SIV type, and their uses in particular for the amplification of the genomes of these retroviruses and for the in vitro diagnosis of the disease due to these viruses

Publications (2)

Publication Number Publication Date
WO1990015066A2 WO1990015066A2 (fr) 1990-12-13
WO1990015066A3 true WO1990015066A3 (fr) 1991-04-18

Family

ID=26227366

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1990/000393 WO1990015066A2 (fr) 1989-06-02 1990-06-05 Sequences nucleotidiques issues du genome des retrovirus du type hiv-1, hiv-2 et siv, et leurs applications notamment pour l'amplification des genomes de ces retrovirus et pour le diagnostic in vitro des infections dues a ces virus

Country Status (12)

Country Link
US (6) US5688637A (fr)
EP (5) EP2011888B1 (fr)
JP (2) JP3428012B2 (fr)
AT (5) ATE185379T1 (fr)
CA (3) CA2685262A1 (fr)
DE (7) DE05014676T1 (fr)
DK (5) DK1715064T3 (fr)
ES (5) ES2315215T1 (fr)
GR (1) GR3032261T3 (fr)
HK (3) HK1092839A1 (fr)
SG (1) SG47868A1 (fr)
WO (1) WO1990015066A2 (fr)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7022814B1 (en) 1992-01-21 2006-04-04 Institut Pasteur And Institut National De La Sante Et De La Recherche Medicale Nucleotide sequences derived from the genome of retroviruses of the HIV-1, HIV-2 and SIV type, and their uses in particular for the amplification of the genomes of these retroviruses and for the in vitro diagnosis of the diseases due to these viruses
ATE185379T1 (de) * 1989-06-02 1999-10-15 Pasteur Institut Nukleotid-sequenzen des genoms von retroviren vom typ hiv-1, hiv-2 und siv, ihre verwendungen zur amplifikation dieser genome und in-vitro-diagnose dieser viralen infektionen
US6589734B1 (en) 1989-07-11 2003-07-08 Gen-Probe Incorporated Detection of HIV
US5856088A (en) * 1989-07-11 1999-01-05 Gen-Probe Incorporated Detection of human immunodeficiency virus type 1
JPH04152899A (ja) * 1990-10-17 1992-05-26 Shionogi & Co Ltd ２段階ｐｃｒ法によるｈｉｖ―１ゲノムの検出法およびオリゴヌクレオチド
FR2677039B1 (fr) * 1991-05-31 1994-09-09 Cis Bio Int Oligonucleotides, utilisables comme reactifs pour la detection in vitro des infections a retrovirus de type hiv et procede de detection de retrovirus de type hiv.
ES2267094T3 (es) 1991-12-23 2007-03-01 Novartis Vaccines And Diagnostics, Inc. Conjunto de sondas de vih para su uso en ensayos de hibridacion en sandwich en fase de disolucion.
FR2692279B1 (fr) * 1992-06-16 1995-05-19 Centre Nat Rech Scient Séquences nucléotidiques issues de la souche WO du vif et leurs fragments, applications desdites séquences à l'expression de peptides immunogènes et au diagnostic de l'immunodéficience féline.
AU686616B2 (en) 1993-03-26 1998-02-12 Gen-Probe Incorporated Detection of human immunodeficiency virus type 1
WO1995005851A1 (fr) * 1993-08-20 1995-03-02 St. Luke's-Roosevelt Hospital Center Compositions relatives au facteur viral infectieux de hiv, utilisations prophylactiques et therapeutiques
US5733781A (en) * 1994-07-19 1998-03-31 Gen-Probe Incorporated Oligonucleotides and methods for inhibiting propagation of human immunodeficiency virus
WO1997021102A1 (fr) 1995-12-05 1997-06-12 Branch Donald R Procedes de detection precoce de la contamination par le vih
US6265152B1 (en) * 1995-12-22 2001-07-24 Visible Genetics Inc. Method and kit for evaluation of HIV mutations
DE19644248A1 (de) * 1996-10-24 1998-04-30 Boehringer Mannheim Gmbh Primer und Probes zum Nachweis von HIV
US6830887B2 (en) 1997-03-18 2004-12-14 Bayer Healthcare Llc Method and kit for quantitation and nucleic acid sequencing of nucleic acid analytes in a sample
US5962665A (en) * 1997-06-16 1999-10-05 Abbott Laboratories Nucleic acid primers and probes for detecting HIV-1 and HIV-2
US6001558A (en) * 1997-06-25 1999-12-14 Ortho Clinical Diagnostics, Inc. Amplification and detection of HIV-1 and/or HIV 2
US6492110B1 (en) 1998-11-02 2002-12-10 Uab Research Foundation Reference clones and sequences for non-subtype B isolates of human immunodeficiency virus type 1
DE19850186A1 (de) * 1998-10-30 2000-05-25 Roche Diagnostics Gmbh Neue Primer und Sonden zum Nachweis von HIV
US6303293B1 (en) * 1999-02-02 2001-10-16 Ortho-Clinical Diagnostics, Inc. Oligonucleotide reverse transcription primers for efficient detection of HIV-1 and HIV-2 and methods of use thereof
AU3219400A (en) * 1999-02-03 2000-08-25 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Methods and reagents for molecular detection of hiv-1 groups m, n and
DE19908766C2 (de) * 1999-02-19 2001-02-15 Ulrich Schubert Verwendung synthetischer Vpr-Peptide des Humanen Immundefizienzvirus Typ 1 (HIV-1) zur Entwicklung von therapeutischen und diagnostischen Reagenzien
WO2000068436A1 (fr) * 1999-05-07 2000-11-16 Nationales Zentrum Für Retroviren Systeme de detection du virus de l'immunodeficience humaine fonde sur l'amplification d'acide nucleique
FR2798385B1 (fr) * 1999-06-21 2003-09-05 Bio Merieux Procede de recherche d'une resistance aux anti-proteases chez des souches du virus vih-2
JP4824236B2 (ja) * 1999-07-09 2011-11-30 ジェン−プローブ・インコーポレーテッド 核酸増幅によるｈｉｖ−１の検出
US20030228600A1 (en) * 2000-07-14 2003-12-11 Eppendorf 5 Prime, Inc. DNA isolation method and kit
CA2835978C (fr) 2000-09-01 2016-10-11 Gen-Probe Incorporated Amplification de sequences vih-1 pour la detection de sequences associees aux mutations de la resistance aux medicaments
US6582920B2 (en) 2000-09-01 2003-06-24 Gen-Probe Incorporated Amplification of HIV-1 RT sequences for detection of sequences associated with drug-resistance mutations
WO2002034951A2 (fr) 2000-10-23 2002-05-02 Gen-Probe Incorporated Compositions et procedes de detection du virus de l'immunodeficience humaine 2 (vih-2)
US6770752B2 (en) 2001-01-09 2004-08-03 Becton, Dickinson And Company Sequences for detection of HIV-1
US7847087B2 (en) * 2001-03-05 2010-12-07 Siemens Healthcare Diagnostics Inc. Methods and primers for evaluating HIV-1 mutations
JP4701532B2 (ja) 2001-04-26 2011-06-15 東ソー株式会社 Ｈｉｖ−１ｒｎａの増幅および検出法
JP2005528082A (ja) * 2001-12-18 2005-09-22 モンドバイオテック・ラボラトリーズ・アンスタルト 間質性肺疾患の治療を向上させるためのインターフェロンγ又はパーフェニドンと分子診断薬との新規医薬組成物
WO2003062377A2 (fr) * 2002-01-17 2003-07-31 The Uab Research Foundation Sequence genomique complete du virus sivcpztan1
CN1301263C (zh) 2002-12-18 2007-02-21 北京昭衍新药研究中心 一组抗hiv感染及防治艾滋病的核苷酸序列及其应用
US20050222068A1 (en) 2003-10-23 2005-10-06 Mourich Dan V Method and antisense composition for selective inhibition of HIV infection in hematopoietic cells
DE602004028862D1 (de) * 2003-12-19 2010-10-07 Gen Probe Inc Der nukleinsäuren von hiv-1 und hiv-2
TW200613554A (en) * 2004-06-17 2006-05-01 Wyeth Corp Plasmid having three complete transcriptional units and immunogenic compositions for inducing an immune response to HIV
US7993647B2 (en) 2004-07-01 2011-08-09 The United States Of America As Represented By The Department Of Health And Human Services Monoclonal antibodies to HIV-1 and methods of using same
EP2742951B1 (fr) 2004-09-14 2016-02-03 Argos Therapeutics, Inc. Amplification de souches indépendantes polynucleotides de VIH
US20090050492A1 (en) * 2005-08-02 2009-02-26 Board Of Trustees Of Michigan State University Nanoporous silicon-based electrochemical nucleic acid biosensor
JP2010521156A (ja) * 2007-03-16 2010-06-24 ４５４ ライフ サイエンシーズ コーポレイション Ｈｉｖ薬物耐性バリアントの検出のためのシステムおよび方法
WO2009017743A2 (fr) 2007-07-30 2009-02-05 Argos Therapeutics, Inc. Amorces et sondes améliorées pour l'amplification et la détection des polynucléotides gag, rev et nef du vih
US8405379B1 (en) 2008-09-18 2013-03-26 Luc Montagnier System and method for the analysis of DNA sequences in biological fluids
US10545149B2 (en) * 2008-10-06 2020-01-28 Morehouse School Of Medicine Detection of HIV-related proteins in urine
CA2746508A1 (fr) 2008-12-17 2010-07-15 Avi Biopharma, Inc. Compositions antisens et methodes de modulation de l'hypersensibilite de contact ou de la dermatite de contact
CA2793959C (fr) 2010-03-25 2019-06-04 Oregon Health & Science University Glycoproteines du cmv et vecteurs recombines
CA2832109C (fr) 2011-06-10 2021-07-06 Oregon Health & Science University Glycoproteines de cmv et vecteurs recombinants cmv
CN102964898B (zh) 2011-08-05 2016-05-25 罗门哈斯公司 具有改进的亲水污渍排斥性的水性涂料组合物
EP2568289A3 (fr) 2011-09-12 2013-04-03 International AIDS Vaccine Initiative Immunosélection du virus de la stomatite vésiculaire recombinant exprimant les protéines du VIH-1 par des anticorps largement neutralisants
US9402894B2 (en) 2011-10-27 2016-08-02 International Aids Vaccine Initiative Viral particles derived from an enveloped virus
ES2631608T3 (es) 2012-06-27 2017-09-01 International Aids Vaccine Initiative Variante de la glicoproteína Env del VIH-1
US20150065381A1 (en) 2013-09-05 2015-03-05 International Aids Vaccine Initiative Methods of identifying novel hiv-1 immunogens
EP2873423B1 (fr) 2013-10-07 2017-05-31 International Aids Vaccine Initiative Trimères de glycoprotéines d'enveloppe du vih -1 soluble
US10174292B2 (en) 2015-03-20 2019-01-08 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
US9931394B2 (en) 2015-03-23 2018-04-03 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0229701A2 (fr) * 1986-01-10 1987-07-22 F. Hoffmann-La Roche Ag Détection des virus par amplification et hybridation
WO1987007300A2 (fr) * 1986-05-23 1987-12-03 Worcester Foundation For Experimental Biology Inhibition de l'htlv-iii par des oligonucleotides exogenes
WO1987007906A1 (fr) * 1986-06-23 1987-12-30 Institut Pasteur Variantes des virus lav, leurs constituants adn et proteiniques, et leurs utilisations, notamment a des fins diagnostiques et pour la preparation de compositions immunogeniques
EP0269520A2 (fr) * 1986-11-21 1988-06-01 Institut Pasteur Rétrovirus du type HIV-2 susceptible de provoquer le sida, et ses constituants antigéniques et nucléiques
EP0269445A2 (fr) * 1986-11-26 1988-06-01 Cetus Oncology Corporation Procédé de détection des virus HTLVI et HTLVII par hybridation
EP0272098A2 (fr) * 1986-12-15 1988-06-22 City Of Hope National Medical Center Procédé d'amplification et de détection de séquences ARN
WO1988005440A1 (fr) * 1987-01-16 1988-07-28 Institut Pasteur Peptides ayant des proprietes immunologiques 2-hiv-2

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE373010T1 (de) * 1984-10-18 2007-09-15 Pasteur Institut Gag-antigen und dessen verwendung zum nachweis von lav-infektion, sowie in immunogenen zusammensetzungen
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
ES8706823A1 (es) 1985-03-28 1987-06-16 Cetus Corp Un procedimiento para detectar la presencia o ausencia de al menos una secuencia especifica de acidos nucleicos en una muestra
US5008182A (en) * 1986-01-10 1991-04-16 Cetus Corporation Detection of AIDS associated virus by polymerase chain reaction
US5386022A (en) 1985-03-28 1995-01-31 Hoffman-La Roche Inc. Primes and probes for the amplification and detection of aids associated nucleic acids
US5176995A (en) 1985-03-28 1993-01-05 Hoffmann-La Roche Inc. Detection of viruses by amplification and hybridization
US5008185A (en) 1985-11-04 1991-04-16 Cell Analysis Systems, Inc. Methods and apparatus for the quantitation of nuclear proteins
US4839288A (en) * 1986-01-22 1989-06-13 Institut Pasteur Retrovirus capable of causing AIDS, antigens obtained from this retrovirus and corresponding antibodies and their application for diagnostic purposes
OA08468A (fr) 1986-01-22 1988-07-29 Pasteur Institut Retrovirus du type HIV-2 susceptible de provoquer le SIDA et ses constituants antigéniques et nucléiques.
US5824482A (en) * 1986-06-23 1998-10-20 Institut Pasteur Purification, cloning, and characterization of a novel human immunodeficiency virus LAVMAL
CA1308372C (fr) * 1986-08-11 1992-10-06 Geneva Ruth Davis Methode d'essai de type sandwich a sonde d'acide nucleique et compositions de ceux-ci
US5268268A (en) 1986-11-26 1993-12-07 Hoffmann-La Roche Inc. Detection of HTLVI and HTLVII viruses by hybridization
CA1340843C (fr) 1987-07-31 1999-12-07 J. Lawrence Burg Amplification selective de sequences polynucleotidiques cibles
US4963532A (en) 1987-11-25 1990-10-16 Hem Research, Inc. dsRNA-based prevention of viral escape
US5389512A (en) 1988-10-07 1995-02-14 Hoffman-La Roche Inc. Method for determining the relative amount of a viral nucleic acid segment in a sample by the polymerase chain reaction
FR2647856B1 (fr) * 1989-05-31 1994-03-04 Framatome Dispositif auxiliaire de relachement commande a distance pour un mecanisme a action positive
ATE185379T1 (de) 1989-06-02 1999-10-15 Pasteur Institut Nukleotid-sequenzen des genoms von retroviren vom typ hiv-1, hiv-2 und siv, ihre verwendungen zur amplifikation dieser genome und in-vitro-diagnose dieser viralen infektionen

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0229701A2 (fr) * 1986-01-10 1987-07-22 F. Hoffmann-La Roche Ag Détection des virus par amplification et hybridation
WO1987007300A2 (fr) * 1986-05-23 1987-12-03 Worcester Foundation For Experimental Biology Inhibition de l'htlv-iii par des oligonucleotides exogenes
WO1987007906A1 (fr) * 1986-06-23 1987-12-30 Institut Pasteur Variantes des virus lav, leurs constituants adn et proteiniques, et leurs utilisations, notamment a des fins diagnostiques et pour la preparation de compositions immunogeniques
EP0269520A2 (fr) * 1986-11-21 1988-06-01 Institut Pasteur Rétrovirus du type HIV-2 susceptible de provoquer le sida, et ses constituants antigéniques et nucléiques
EP0269445A2 (fr) * 1986-11-26 1988-06-01 Cetus Oncology Corporation Procédé de détection des virus HTLVI et HTLVII par hybridation
EP0272098A2 (fr) * 1986-12-15 1988-06-22 City Of Hope National Medical Center Procédé d'amplification et de détection de séquences ARN
WO1988005440A1 (fr) * 1987-01-16 1988-07-28 Institut Pasteur Peptides ayant des proprietes immunologiques 2-hiv-2

Also Published As

Publication number Publication date
DK1642987T3 (da) 2008-12-01
EP1642987B1 (fr) 2008-08-13
ATE185379T1 (de) 1999-10-15
EP0806484B1 (fr) 2006-04-12
ES2275451T1 (es) 2007-06-16
EP0403333A3 (fr) 1991-11-21
EP1642987A3 (fr) 2006-08-23
JP3428012B2 (ja) 2003-07-22
ATE404699T1 (de) 2008-08-15
EP1715064B1 (fr) 2009-02-25
ES2139567T3 (es) 2000-02-16
CA2585164A1 (fr) 1990-12-13
EP1715064A1 (fr) 2006-10-25
US7078516B1 (en) 2006-07-18
DE69034265D1 (de) 2009-04-09
DE69033311D1 (de) 1999-11-11
DE69034220T2 (de) 2006-12-28
CA2062829A1 (fr) 1990-12-03
ES2321326T3 (es) 2009-06-04
US20060035260A1 (en) 2006-02-16
US7777020B2 (en) 2010-08-17
CA2585164C (fr) 2010-02-02
US7759477B2 (en) 2010-07-20
DK1715064T3 (da) 2009-06-22
US20050037340A1 (en) 2005-02-17
EP2011888B1 (fr) 2010-04-28
ES2275451T3 (es) 2009-02-16
DE69034267D1 (de) 2010-06-10
DE69034220D1 (de) 2006-05-24
GR3032261T3 (en) 2000-04-27
DK0403333T3 (da) 2000-03-20
JP2000093187A (ja) 2000-04-04
ATE423856T1 (de) 2009-03-15
ES2262166T3 (es) 2006-11-16
DK0806484T3 (da) 2006-08-14
EP0806484A3 (fr) 2000-09-13
JPH04507043A (ja) 1992-12-10
ATE323183T1 (de) 2006-04-15
CA2062829C (fr) 2007-08-07
SG47868A1 (en) 1998-04-17
WO1990015066A2 (fr) 1990-12-13
DE69034260D1 (de) 2008-09-25
US5688637A (en) 1997-11-18
EP1715064A8 (fr) 2007-05-16
CA2685262A1 (fr) 1990-12-13
EP0806484A2 (fr) 1997-11-12
EP0403333A2 (fr) 1990-12-19
HK1125136A1 (en) 2009-07-31
ATE466111T1 (de) 2010-05-15
DE05014676T1 (de) 2007-05-10
EP2011888A1 (fr) 2009-01-07
US5786177A (en) 1998-07-28
ES2315215T1 (es) 2009-04-01
DE07025195T1 (de) 2009-05-07
DK2011888T3 (da) 2010-08-09
EP0403333B1 (fr) 1999-10-06
HK1097574A1 (en) 2007-06-29
HK1092839A1 (en) 2007-02-16
DE69033311T2 (de) 2000-02-17
US6194142B1 (en) 2001-02-27
EP1642987A2 (fr) 2006-04-05

Similar Documents

Publication Publication Date Title
WO1990015066A3 (fr) Sequences nucleotidiques issues du genome des retrovirus du type hiv-1, hiv-2 et siv, et leurs applications notamment pour l'amplification des genomes de ces retrovirus et pour le diagnostic in vitro des infections dues a ces virus
EP0887427A3 (fr) Amplification et détection du HIV-1 et/or HIV-2
EP0404625A3 (fr) Séquences oligonucléotidiques pour l'amplification du génome des rétrovirus du type HIV-2 et SIV, et leurs applications au diagnostic in-vitro des infections dûes à ces virus
DK33190A (da) Hiv-3 retrovirus og anvendelse heraf
EP0885887A3 (fr) Sulfonamides inhibiteurs d'aspartyle protéase du VIH
FR2731013B1 (fr) Vih-1 de groupe o, fragments desdits virus, ainsi que leurs applications
FR2756843B1 (fr) Souches de vih-1 non-m non-o, fragments et applications
CA2195125A1 (fr) Agents antiviraux a base de difluorostatone
WO1990013281A3 (fr) Procede de suppression d'une infection par l'hiv
DK0681578T3 (da) Antivirale naphtoquinonforbindelser, sammensætninger og anvendelser deraf
FR2647809B1 (fr) Amorces oligonucleotidiques pour l'amplification du genome des retrovirus du type hiv-1, hiv-2 et siv, et leurs applications au diagnostic in vitro des infections dues a ces virus
FR2652091B1 (fr) Sequences nucleotidiques issues du genome des retrovirus du type hiv-1, hiv-2 et siv, et leurs applications notamment pour l'amplification des genomes de ces retrovirus et pour le diagnostic in-vitro des infections dues a ces virus.
ES2155515T3 (es) Derivados de difluorostatona macrociclica utiles como agentes antivirales.
Zekeng Update on HIV/SIV infections in Cameroon
ES2084587T3 (es) Arn virus no revertientes.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): CA JP US

AK Designated states

Kind code of ref document: A3

Designated state(s): CA JP US

WWE Wipo information: entry into national phase

Ref document number: 2062829

Country of ref document: CA