WO1991000046A3 - Method and apparatus for preparing fibrinogen adhesive from whole blood - Google Patents

Method and apparatus for preparing fibrinogen adhesive from whole blood Download PDF

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Publication number
WO1991000046A3
WO1991000046A3 PCT/US1990/003598 US9003598W WO9100046A3 WO 1991000046 A3 WO1991000046 A3 WO 1991000046A3 US 9003598 W US9003598 W US 9003598W WO 9100046 A3 WO9100046 A3 WO 9100046A3
Authority
WO
WIPO (PCT)
Prior art keywords
fibrinogen adhesive
whole blood
preparing fibrinogen
disclosed
adhesive composition
Prior art date
Application number
PCT/US1990/003598
Other languages
French (fr)
Other versions
WO1991000046A2 (en
Inventor
Gordon Epstein
Original Assignee
Gordon Epstein
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gordon Epstein filed Critical Gordon Epstein
Publication of WO1991000046A2 publication Critical patent/WO1991000046A2/en
Publication of WO1991000046A3 publication Critical patent/WO1991000046A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491—Surgical glue applicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/106—Fibrin; Fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491—Surgical glue applicators
    • A61B2017/00495—Surgical glue applicators for two-component glue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S604/00—Surgery
    • Y10S604/902—Suction wands

Abstract

A process and apparatus for one-step preparation of fibrinogen adhesive by polyethylene glycol-mediated precipitation from plasma are disclosed. The methods and apparatus of the invention permit preparation of autologous fibrinogen adhesive composition from the patient during surgery, and can be applied generally to provide such compositions. Also disclosed are an apparatus and method for application of sealant comprising this fibrinogen adhesive composition.
PCT/US1990/003598 1989-06-23 1990-06-25 Method and apparatus for preparing fibrinogen adhesive from whole blood WO1991000046A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US372,443 1989-06-23
US07/372,443 US5226877A (en) 1989-06-23 1989-06-23 Method and apparatus for preparing fibrinogen adhesive from whole blood

Publications (2)

Publication Number Publication Date
WO1991000046A2 WO1991000046A2 (en) 1991-01-10
WO1991000046A3 true WO1991000046A3 (en) 1996-10-31

Family

ID=23468141

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1990/003598 WO1991000046A2 (en) 1989-06-23 1990-06-25 Method and apparatus for preparing fibrinogen adhesive from whole blood

Country Status (3)

Country Link
US (7) US5226877A (en)
AU (1) AU5853990A (en)
WO (1) WO1991000046A2 (en)

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US20020128683A1 (en) 2002-09-12
US20050101992A9 (en) 2005-05-12
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US6394975B1 (en) 2002-05-28
US5976102A (en) 1999-11-02
US5648265A (en) 1997-07-15
US5879340A (en) 1999-03-09
US5405607A (en) 1995-04-11
US5226877A (en) 1993-07-13
WO1991000046A2 (en) 1991-01-10

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