WO1991008478A3 - METHODS OF DETECTING COLLAGEN DEGRADATION $i(IN VIVO) - Google Patents

METHODS OF DETECTING COLLAGEN DEGRADATION $i(IN VIVO) Download PDF

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Publication number
WO1991008478A3
WO1991008478A3 PCT/US1990/007015 US9007015W WO9108478A3 WO 1991008478 A3 WO1991008478 A3 WO 1991008478A3 US 9007015 W US9007015 W US 9007015W WO 9108478 A3 WO9108478 A3 WO 9108478A3
Authority
WO
WIPO (PCT)
Prior art keywords
vivo
methods
collagen degradation
cross
quantitating
Prior art date
Application number
PCT/US1990/007015
Other languages
French (fr)
Other versions
WO1991008478A2 (en
Inventor
David R Eyre
Original Assignee
Washington Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27034100&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1991008478(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/444,881 external-priority patent/US5140103A/en
Application filed by Washington Res Found filed Critical Washington Res Found
Priority to EP91900109A priority Critical patent/EP0502928B1/en
Priority to DE69025199T priority patent/DE69025199T2/en
Priority to DE0502928T priority patent/DE502928T1/en
Priority to SU5052245A priority patent/RU2139541C1/en
Publication of WO1991008478A2 publication Critical patent/WO1991008478A2/en
Publication of WO1991008478A3 publication Critical patent/WO1991008478A3/en
Priority to NO922149A priority patent/NO309483B1/en
Priority to GR940300047T priority patent/GR940300047T1/en
Priority to GR960400036T priority patent/GR3018852T3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6881—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4712—Muscle proteins, e.g. myosin, actin, protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/105—Osteoarthritis, e.g. cartilage alteration, hypertrophy of bone
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/108—Osteoporosis

Abstract

Methods of determining collagen degradation in vivo, by quantitating the concentration of a peptide in a body fluid, the peptide being a C-terminal type II collagen telopeptide containing a hydroxylysyl pyridinoline cross-link or a type III collagen telopeptide containing a hydroxylysyl pyridinoline cross-link. Suitable methods include immunometric assays, fluorometric assays, and electrochemical titrations for quantitation. The structures of specific peptides having cross-links and kits for quantitating these peptides in a body fluid are described.
PCT/US1990/007015 1989-12-01 1990-11-30 METHODS OF DETECTING COLLAGEN DEGRADATION $i(IN VIVO) WO1991008478A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP91900109A EP0502928B1 (en) 1989-12-01 1990-11-30 Methods of detecting bone resorption in vivo
DE69025199T DE69025199T2 (en) 1989-12-01 1990-11-30 METHOD FOR IN VIVO DETECTION OF BONE RESORPTION
DE0502928T DE502928T1 (en) 1989-12-01 1990-11-30 METHOD FOR VIVO DETECTING COLLAGEN DEGRADATION.
SU5052245A RU2139541C1 (en) 1989-12-01 1990-11-30 Methods of assay of collagen destruction in vivo and sets for realization of methods, hybridoma, monoclonal antibody and its fragment, peptides of collagen and method of assay
NO922149A NO309483B1 (en) 1989-12-01 1992-05-29 Immunological binding partner and use of the same
GR940300047T GR940300047T1 (en) 1989-12-01 1994-07-29 Methods of detecting bone resorption in vivo
GR960400036T GR3018852T3 (en) 1989-12-01 1996-02-01 Methods of detecting bone resorption in vivo

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US444,881 1989-12-01
US07/444,881 US5140103A (en) 1987-11-06 1989-12-01 Peptide fragments containing HP and LP cross-links
US07/614,719 US5300434A (en) 1987-11-06 1990-11-21 Hybridoma cell line producing an antibody to type-I collagen amino-terminal telopeptide
US614,719 1990-11-21

Publications (2)

Publication Number Publication Date
WO1991008478A2 WO1991008478A2 (en) 1991-06-13
WO1991008478A3 true WO1991008478A3 (en) 1991-11-28

Family

ID=27034100

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1990/007015 WO1991008478A2 (en) 1989-12-01 1990-11-30 METHODS OF DETECTING COLLAGEN DEGRADATION $i(IN VIVO)

Country Status (13)

Country Link
US (5) US5300434A (en)
EP (6) EP1560026A1 (en)
JP (6) JP2782017B2 (en)
AT (3) ATE133790T1 (en)
AU (1) AU645049B2 (en)
DE (4) DE69034170T2 (en)
DK (3) DK0682256T3 (en)
ES (2) ES2133656T3 (en)
GR (3) GR940300047T1 (en)
IE (1) IE65280B1 (en)
NO (1) NO309483B1 (en)
RU (1) RU2139541C1 (en)
WO (1) WO1991008478A2 (en)

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Also Published As

Publication number Publication date
WO1991008478A2 (en) 1991-06-13
DE69033082T2 (en) 1999-09-30
NO922149L (en) 1992-07-29
ATE279730T1 (en) 2004-10-15
US5656439A (en) 1997-08-12
EP0890840A2 (en) 1999-01-13
ATE179521T1 (en) 1999-05-15
EP0682256A1 (en) 1995-11-15
JPH09113510A (en) 1997-05-02
JP2000050865A (en) 2000-02-22
GR3030646T3 (en) 1999-10-29
IE65280B1 (en) 1995-10-18
JP2000055915A (en) 2000-02-25
DE502928T1 (en) 1994-08-18
IE904344A1 (en) 1991-06-05
DE69034170D1 (en) 2004-11-18
JP2782017B2 (en) 1998-07-30
ES2061422T1 (en) 1994-12-16
EP0682257A1 (en) 1995-11-15
JPH10260183A (en) 1998-09-29
JP2999444B2 (en) 2000-01-17
JP2999416B2 (en) 2000-01-17
EP1632502A1 (en) 2006-03-08
US5576189A (en) 1996-11-19
DK0682256T3 (en) 2005-02-14
EP0502928B1 (en) 1996-01-31
JPH05502223A (en) 1993-04-22
DE69033082D1 (en) 1999-06-02
US5677198A (en) 1997-10-14
DE69025199D1 (en) 1996-03-14
EP0502928A1 (en) 1992-09-16
ES2133656T3 (en) 1999-09-16
AU6889891A (en) 1991-06-26
EP1560026A1 (en) 2005-08-03
JP2002139492A (en) 2002-05-17
NO922149D0 (en) 1992-05-29
AU645049B2 (en) 1994-01-06
JP3299941B2 (en) 2002-07-08
NO309483B1 (en) 2001-02-05
DK0682257T3 (en) 1999-11-08
EP0682257B1 (en) 1999-04-28
RU2139541C1 (en) 1999-10-10
GR3018852T3 (en) 1996-05-31
GR940300047T1 (en) 1994-07-29
DE69034170T2 (en) 2006-03-02
EP0682256B1 (en) 2004-10-13
EP0890840A3 (en) 2000-05-17
DK0502928T3 (en) 1996-02-19
DE69025199T2 (en) 1996-05-30
ATE133790T1 (en) 1996-02-15
ES2061422T3 (en) 1996-03-16
US5300434A (en) 1994-04-05
US5473052A (en) 1995-12-05

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