WO1991014456A3 - Improved compositions for photodynamic therapy - Google Patents

Improved compositions for photodynamic therapy Download PDF

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Publication number
WO1991014456A3
WO1991014456A3 PCT/CA1991/000093 CA9100093W WO9114456A3 WO 1991014456 A3 WO1991014456 A3 WO 1991014456A3 CA 9100093 W CA9100093 W CA 9100093W WO 9114456 A3 WO9114456 A3 WO 9114456A3
Authority
WO
WIPO (PCT)
Prior art keywords
photosensitizer
photodynamic therapy
conjugation
specific component
target specific
Prior art date
Application number
PCT/CA1991/000093
Other languages
French (fr)
Other versions
WO1991014456A2 (en
Inventor
Daniel Liu
Original Assignee
Quadra Logic Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quadra Logic Tech Inc filed Critical Quadra Logic Tech Inc
Publication of WO1991014456A2 publication Critical patent/WO1991014456A2/en
Publication of WO1991014456A3 publication Critical patent/WO1991014456A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof

Abstract

Porphyrin-type photosensitizers useful in photodynamic therapy can be formulated as water soluble drugs by conjugation of the photosensitizer to a hydrophilic polymer. Conjugation of the photosensitizer in varying ratios to the polymer, such as polyvinyl alcohol, provides compositions which are readily soluble and biodistribute in a fashion equal to or advantageous over that obtained when the photosensitizer is administered alone. In addition, these conjugates which further contain a target specific component provide a mechanism for homing to the desired target tissue, as well as offering a convenient approach to including both target specific component and photosensitizing drug in the same complex.
PCT/CA1991/000093 1990-03-22 1991-03-22 Improved compositions for photodynamic therapy WO1991014456A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/498,042 US5053423A (en) 1990-03-22 1990-03-22 Compositions for photodynamic therapy
US498,042 1990-03-22

Publications (2)

Publication Number Publication Date
WO1991014456A2 WO1991014456A2 (en) 1991-10-03
WO1991014456A3 true WO1991014456A3 (en) 1991-12-12

Family

ID=23979389

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1991/000093 WO1991014456A2 (en) 1990-03-22 1991-03-22 Improved compositions for photodynamic therapy

Country Status (3)

Country Link
US (1) US5053423A (en)
AU (1) AU7474791A (en)
WO (1) WO1991014456A2 (en)

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US5880287A (en) * 1990-05-15 1999-03-09 Hyperion, Inc. Polyoxyhydrocarbyl related products and methods for fluorescence assays
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US6060598A (en) * 1990-05-15 2000-05-09 Hyperion, Inc. Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding
US5919922A (en) * 1990-05-15 1999-07-06 Hyperion, Inc. Fluorescent dyes free of aggregation and serum binding
US5622685A (en) * 1990-05-30 1997-04-22 Deutches Krebsforchunszentrum Stiftung Des Offentlichen Rechts Polyether-substituted porphyrin anti-tumor agents
CA2047969A1 (en) * 1990-08-17 1992-02-18 Thomas D. Madden Benzoporphyrin vesicles
US5169944A (en) * 1991-04-12 1992-12-08 Board Of Regents Of The University Of Washington Methods and compositions for the enteral administration of hepatobiliary MRI contrast agents
IL104734A0 (en) * 1993-02-15 1993-06-10 Univ Bar Ilan Bioactive conjugates of cellulose with amino compounds
US5667775A (en) 1993-08-11 1997-09-16 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
US5496545A (en) * 1993-08-11 1996-03-05 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
KR100361933B1 (en) 1993-09-08 2003-02-14 라 졸라 파마슈티칼 컴파니 Chemically defined nonpolymeric bonds form the platform molecule and its conjugate
US6551618B2 (en) 1994-03-15 2003-04-22 University Of Birmingham Compositions and methods for delivery of agents for neuronal regeneration and survival
US6992107B1 (en) * 1995-03-10 2006-01-31 Photocure Asa Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy
US5707608A (en) * 1995-08-02 1998-01-13 Qlt Phototherapeutics, Inc. Methods of making liposomes containing hydro-monobenzoporphyrin photosensitizer
US5834503A (en) * 1996-06-14 1998-11-10 Qlt Phototherapeutics, Inc. Methods to treat arterial plaque
US7157418B1 (en) 1998-07-22 2007-01-02 Osprey Pharmaceuticals, Ltd. Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders
US20030215421A1 (en) * 1999-07-21 2003-11-20 Mcdonald John R. Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders
WO2000012512A1 (en) 1998-08-28 2000-03-09 Destiny Pharma Limited Porphyrin derivatives, their use in photodynamic therapy and medical devices containing them
US6458953B1 (en) * 1998-12-09 2002-10-01 La Jolla Pharmaceutical Company Valency platform molecules comprising carbamate linkages
US6733780B1 (en) 1999-10-19 2004-05-11 Genzyme Corporation Direct compression polymer tablet core
CN1434726A (en) 2000-06-08 2003-08-06 拉卓拉药物公司 Multivalent platform molecules comprising high molecular weight polyethylene oxide
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US7175611B2 (en) 2002-06-05 2007-02-13 Mark Alan Mitchnick Antimicrobial release system
ATE292144T1 (en) 2002-08-02 2005-04-15 Inst Curie SHIGA TOXIN SUBUNIT B AS A VECTOR FOR DIAGNOSIS OF TUMORS AND FOR DRUG ADMINISTRATION TO GB3-EXPRESSING TUMORS
US20060231107A1 (en) * 2003-03-07 2006-10-19 Glickman Randolph D Antibody-targeted photodynamic therapy
AU2004297228A1 (en) 2003-12-03 2005-06-23 Nektar Therapeutics Al, Corporation Method of preparing maleimide functionalized polymers
US7985418B2 (en) * 2004-11-01 2011-07-26 Genzyme Corporation Aliphatic amine polymer salts for tableting
JP2008526771A (en) * 2004-12-30 2008-07-24 ジェンザイム コーポレーション Zinc-containing treatment for hyperphosphatemia
US20060223750A1 (en) * 2005-04-01 2006-10-05 Allergan, Inc. Agents and methods for enhancing photodynamic therapy
CN101268118B (en) 2005-07-19 2012-09-19 尼克塔治疗公司 Method for preparing polymer maleimides
EP1951266A2 (en) 2005-09-02 2008-08-06 Genzyme Corporation Method for removing phosphate and polymer used therefore
WO2007035313A2 (en) 2005-09-15 2007-03-29 Genzyme Corporation Sachet formulation for amine polymers
AR060690A1 (en) * 2005-11-08 2008-07-10 Genzyme Corp POLYMERS CONTAINING MAGNESIUM FOR HYPERPHOSPHATEMIA
US20100135950A1 (en) * 2006-07-05 2010-06-03 Genzyme Corporation Iron(II)-Containing Treatments for Hyperphosphatemia
US8556950B2 (en) 2006-08-24 2013-10-15 Boston Scientific Scimed, Inc. Sterilizable indwelling catheters
ATE454146T1 (en) * 2006-08-29 2010-01-15 Stichting Tech Wetenschapp PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF MYCOTIC SKIN DISEASES AND METHOD FOR THE PRODUCTION THEREOF
KR101035269B1 (en) * 2007-04-23 2011-05-26 한국과학기술연구원 Novel photosensitizer based on pholymer derivatives-photosensitizer conjugates for photodynamic therapy
EP2113257A1 (en) * 2008-04-30 2009-11-04 Consorzio per il Centro di Biomedica Moleculare Scrl Polyelectrolyte with positive net charge for use as medicament and diagnostic for cancer
SG11201405553YA (en) 2012-03-08 2014-11-27 Halozyme Inc Conditionally active anti-epidermal growth factor receptor antibodies and methods of use thereof
KR101419254B1 (en) 2012-10-15 2014-07-17 국립암센터 Enzyme-responsive graphene oxide/biopolymer-photosensitizer nanocomplex and composition for fluorescence image and photodynamic/photothermal treatment comprising thereof
KR20160055253A (en) 2013-09-12 2016-05-17 할로자임, 아이엔씨 Modified anti-epidermal growth factor receptor antibodies and methods of use thereof
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Also Published As

Publication number Publication date
WO1991014456A2 (en) 1991-10-03
US5053423A (en) 1991-10-01
AU7474791A (en) 1991-10-21

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