WO1991015244A3 - Stable microbubbles suspensions injectable into living organisms - Google Patents

Stable microbubbles suspensions injectable into living organisms Download PDF

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Publication number
WO1991015244A3
WO1991015244A3 PCT/EP1991/000620 EP9100620W WO9115244A3 WO 1991015244 A3 WO1991015244 A3 WO 1991015244A3 EP 9100620 W EP9100620 W EP 9100620W WO 9115244 A3 WO9115244 A3 WO 9115244A3
Authority
WO
WIPO (PCT)
Prior art keywords
living organisms
stable microbubbles
microbubbles suspensions
injectable
suspensions injectable
Prior art date
Application number
PCT/EP1991/000620
Other languages
French (fr)
Other versions
WO1991015244A2 (en
Inventor
Michel Schneider
Daniel Bichon
Philippe Bussat
Jerome Puginier
Eva Hybl
Original Assignee
Sint Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8205915&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1991015244(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sint Sa filed Critical Sint Sa
Priority to KR1019910701733A priority Critical patent/KR960002184B1/en
Priority to EP91907163A priority patent/EP0474833B2/en
Priority to DE69111719T priority patent/DE69111719T3/en
Priority to CA002056371A priority patent/CA2056371C/en
Publication of WO1991015244A2 publication Critical patent/WO1991015244A2/en
Publication of WO1991015244A3 publication Critical patent/WO1991015244A3/en
Priority to US08/128,540 priority patent/US5380519A/en
Priority to US08/315,347 priority patent/US5531980A/en
Priority to US08/457,581 priority patent/US5567414A/en
Priority to US08/456,385 priority patent/US5658551A/en
Priority to GR950402454T priority patent/GR3017324T3/en
Priority to US08/853,936 priority patent/US6110443A/en
Priority to US08/893,371 priority patent/US7033574B1/en
Priority to US09/115,963 priority patent/USRE39146E1/en
Priority to US09/401,836 priority patent/US20010012507A1/en
Priority to US09/401,835 priority patent/US20010008626A1/en
Priority to US09/401,838 priority patent/US6613306B1/en
Priority to US09/748,120 priority patent/US20010024640A1/en
Priority to US10/061,299 priority patent/US6881397B2/en
Priority to US10/102,684 priority patent/US20030064030A1/en
Priority to US10/120,390 priority patent/US6989141B2/en
Priority to US10/226,244 priority patent/US6896875B2/en
Priority to US10/336,823 priority patent/US20030194376A1/en
Priority to US10/336,760 priority patent/US20030185759A1/en
Priority to US10/809,677 priority patent/US20040208826A1/en
Priority to US10/962,460 priority patent/US20050058605A1/en
Priority to US11/085,169 priority patent/US20050207980A1/en
Priority to US11/231,865 priority patent/US20060034771A1/en
Priority to US11/444,362 priority patent/US20060257321A1/en
Priority to US11/851,769 priority patent/US20080063603A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric

Abstract

Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.
PCT/EP1991/000620 1990-04-02 1991-04-02 Stable microbubbles suspensions injectable into living organisms WO1991015244A2 (en)

Priority Applications (28)

Application Number Priority Date Filing Date Title
KR1019910701733A KR960002184B1 (en) 1990-04-02 1991-04-02 Microbubble suspensions injectable into living organisms and the
EP91907163A EP0474833B2 (en) 1990-04-02 1991-04-02 Stable microbubbles suspensions injectable into living organisms
DE69111719T DE69111719T3 (en) 1990-04-02 1991-04-02 STABLE MICROBASE SUSPENSIONS FOR INJECTION IN LIVING.
CA002056371A CA2056371C (en) 1990-04-02 1991-04-02 Stable microbubbles suspensions injectable into living organisms
US08/128,540 US5380519A (en) 1990-04-02 1993-09-29 Stable microbubbles suspensions injectable into living organisms
US08/315,347 US5531980A (en) 1990-04-02 1994-09-30 Stable microbubbles suspensions injectable into living organisms
US08/456,385 US5658551A (en) 1990-04-02 1995-06-01 Stable microbubbles suspensions injectable into living organisms
US08/457,581 US5567414A (en) 1990-04-02 1995-06-01 Stable microbubbles suspensions injectable into living organisms
GR950402454T GR3017324T3 (en) 1990-04-02 1995-09-06 Stable microbubbles suspensions injectable into living organisms.
US08/853,936 US6110443A (en) 1990-04-02 1997-05-09 Dry stable formation to produce microbubble suspension for ultrasound
US08/893,371 US7033574B1 (en) 1990-04-02 1997-07-15 Stable microbubbles suspensions injectable into living organisms
US09/115,963 USRE39146E1 (en) 1990-04-02 1998-07-15 Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US09/401,836 US20010012507A1 (en) 1990-04-02 1999-09-22 Ultrasound contrast agents and methods of making and using them
US09/401,835 US20010008626A1 (en) 1990-04-02 1999-09-22 Ultrasound contrast agents and methods of making and using them
US09/401,838 US6613306B1 (en) 1990-04-02 1999-09-22 Ultrasound contrast agents and methods of making and using them
US09/748,120 US20010024640A1 (en) 1990-04-02 2000-12-27 Ultrasound contrast agents and methods of making and using them
US10/061,299 US6881397B2 (en) 1990-04-02 2002-02-04 Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US10/102,684 US20030064030A1 (en) 1990-04-02 2002-03-22 Ultrasound contrast agents and methods of making and using them
US10/120,390 US6989141B2 (en) 1990-05-18 2002-04-12 Ultrasound contrast agents and methods of making and using them
US10/226,244 US6896875B2 (en) 1990-04-02 2002-08-23 Mixable combination for generating a suspension of stable microbubbles for ultrasonic imaging
US10/336,823 US20030194376A1 (en) 1990-05-18 2003-01-06 Ultrasound contrast agents and methods of making and using them
US10/336,760 US20030185759A1 (en) 1990-05-18 2003-01-06 Ultrasound contrast agents and methods of making and using them
US10/809,677 US20040208826A1 (en) 1990-04-02 2004-03-26 Ultrasound contrast agents and methods of making and using them
US10/962,460 US20050058605A1 (en) 1990-04-02 2004-10-13 Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US11/085,169 US20050207980A1 (en) 1990-04-02 2005-03-22 Stable microbubbles suspensions injectable into living organisms
US11/231,865 US20060034771A1 (en) 1990-04-02 2005-09-22 Ultrasound contrast agents and methods of making and using them
US11/444,362 US20060257321A1 (en) 1990-04-02 2006-06-01 Ultrasound contrast agents and methods of making and using them
US11/851,769 US20080063603A1 (en) 1990-04-02 2007-09-07 Ultrasound contrast agents and methods of making and using them

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP90810262.7 1990-04-02
EP90810262 1990-04-02

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US07/775,989 A-371-Of-International US5271928A (en) 1990-04-02 1991-04-02 Stable microbubbles suspensions injectable into living organisms
US08/128,540 Division US5380519A (en) 1990-04-02 1993-09-29 Stable microbubbles suspensions injectable into living organisms
US08/380,588 Division US5578292A (en) 1990-04-02 1995-01-30 Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof

Publications (2)

Publication Number Publication Date
WO1991015244A2 WO1991015244A2 (en) 1991-10-17
WO1991015244A3 true WO1991015244A3 (en) 1991-11-14

Family

ID=8205915

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1991/000620 WO1991015244A2 (en) 1990-04-02 1991-04-02 Stable microbubbles suspensions injectable into living organisms

Country Status (19)

Country Link
US (13) US5271928A (en)
EP (1) EP0474833B2 (en)
JP (3) JP2842453B2 (en)
KR (1) KR960002184B1 (en)
CN (1) CN1055413C (en)
AT (1) ATE125711T1 (en)
AU (1) AU630030B2 (en)
CA (1) CA2056371C (en)
DE (1) DE69111719T3 (en)
DK (1) DK0474833T4 (en)
ES (1) ES2075438T5 (en)
GR (1) GR3017324T3 (en)
IE (1) IE69018B1 (en)
IL (1) IL97730A (en)
IN (1) IN172208B (en)
IS (1) IS3686A7 (en)
NZ (1) NZ237637A (en)
WO (1) WO1991015244A2 (en)
ZA (1) ZA912427B (en)

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