WO1991015602A1 - Human neuronal nicotinic acetylcholine receptor compositions and methods employing same - Google Patents
Human neuronal nicotinic acetylcholine receptor compositions and methods employing same Download PDFInfo
- Publication number
- WO1991015602A1 WO1991015602A1 PCT/US1991/002311 US9102311W WO9115602A1 WO 1991015602 A1 WO1991015602 A1 WO 1991015602A1 US 9102311 W US9102311 W US 9102311W WO 9115602 A1 WO9115602 A1 WO 9115602A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cells
- nicotinic acetylcholine
- subunit
- neuronal nicotinic
- human
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Neurology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002078572A CA2078572C (en) | 1990-04-03 | 1991-04-03 | Human neuronal nicotinic acetylcholine receptor compositions and methods employing same |
DE69133135T DE69133135T2 (en) | 1990-04-03 | 1991-04-03 | HUMAN NEURONAL NICOTINE ACETYLCHOLINE RECEPTOR COMPOUNDS AND METHODS OF USE |
AT91908704T ATE226247T1 (en) | 1990-04-03 | 1991-04-03 | HUMAN NEURONAL NICOTINE-ACETYLCHOLINE RECEPTOR COMPOUNDS AND METHODS OF THEIR USE |
US07/938,154 US5981193A (en) | 1990-04-03 | 1991-04-03 | Human neuronal nicotinic acetylcholine receptor compositions and methods employing same |
EP91908704A EP0523187B1 (en) | 1990-04-03 | 1991-04-03 | Human neuronal nicotinic acetylcholine receptor compositions and methods employing same |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US504,455 | 1990-04-03 | ||
US07/504,455 US5369028A (en) | 1990-04-03 | 1990-04-03 | DNA and mRNA encoding human neuronal nicotinic acetylcholine receptor compositions and cells transformed with same |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1991015602A1 true WO1991015602A1 (en) | 1991-10-17 |
Family
ID=24006339
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1991/002311 WO1991015602A1 (en) | 1990-04-03 | 1991-04-03 | Human neuronal nicotinic acetylcholine receptor compositions and methods employing same |
Country Status (7)
Country | Link |
---|---|
US (2) | US5369028A (en) |
EP (1) | EP0523187B1 (en) |
AT (1) | ATE226247T1 (en) |
CA (1) | CA2078572C (en) |
DE (1) | DE69133135T2 (en) |
ES (1) | ES2183801T3 (en) |
WO (1) | WO1991015602A1 (en) |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993011257A2 (en) * | 1991-11-25 | 1993-06-10 | Boehringer Ingelheim International Gmbh | Process for screening substances capable of modulating a receptor-dependent cellular signal transmission path |
WO1993013423A1 (en) * | 1991-12-20 | 1993-07-08 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Automated analysis equipment and assay method for detecting cell surface protein and/or cytoplasmic receptor function using same |
WO1994020617A2 (en) * | 1993-03-08 | 1994-09-15 | The Salk Institute Biotechnology/Industrial Associates, Incorporated | Human neuronal nicotinic acetylcholine receptor compositions and methods employing same |
US5436128A (en) * | 1990-08-07 | 1995-07-25 | Salk Institute Biotechnology/Industrial Associates | Assay methods and compositions for detecting and evaluating the intracellular transduction of an extracellular signal |
WO1996003504A1 (en) * | 1994-07-21 | 1996-02-08 | The Salk Institute For Biological Studies | Cloning and expression of an acetylcholine-gated ion channel receptor subunit |
GB2287941B (en) * | 1993-11-08 | 1998-01-28 | Salk Inst Biotech Ind | Human alpha2 neuronal nicotinic acetylcholine receptor compositions and methods employing same |
US5981193A (en) * | 1990-04-03 | 1999-11-09 | Sibia Neurosciences, Inc. | Human neuronal nicotinic acetylcholine receptor compositions and methods employing same |
WO2000024887A2 (en) * | 1998-10-27 | 2000-05-04 | Alfred Maelicke | Method for biotechnological production of ligand binding, especially extracellular, fragments of receptor subunits, especially neuroreceptors and hormone receptors |
US6177242B1 (en) * | 1994-12-14 | 2001-01-23 | Institut Pasteur | Genomic DNA fragments containing regulatory and coding sequences for the β2-subunit of the neuronal nicotinic acetylcholine receptor and transgenic animals made using these fragments or mutated fragments |
US6440681B1 (en) | 1990-04-03 | 2002-08-27 | Merck & Co., Inc. | Methods for identifying agonists and antagonists for human neuronal nicotinic acetylcholine receptors |
US6485967B1 (en) | 1995-06-07 | 2002-11-26 | Merck & Co., Inc. | Human neuronal nicotinic acetylcholine receptor α6 and β3 nucleic acid |
US6528630B1 (en) | 1997-12-03 | 2003-03-04 | Merck & Co., Inc. | Calcium channel compositions and methods |
US6632823B1 (en) | 1997-12-22 | 2003-10-14 | Merck & Co., Inc. | Substituted pyridine compounds useful as modulators of acetylcholine receptors |
US6746864B1 (en) * | 1994-08-08 | 2004-06-08 | Science Applications International Corporation | Automated system for simultaneously performing a plurality of signal-based assays |
US6777236B1 (en) | 1994-12-14 | 2004-08-17 | Institut Pasteur | Process for producing a neuronal host cell in vitro comprising regulatory sequences of the β2-subunit of the neuronal nicotinic acetylcholine receptor |
US7700749B2 (en) | 2001-08-31 | 2010-04-20 | Agensys, Inc. | Nucleic acid and corresponding protein entitled 205P1B5 useful in treatment and detection of cancer |
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ATE199391T1 (en) | 1990-09-13 | 2001-03-15 | Univ Duke | EXPRESSION OF RECEPTORS COUPLED TO G-PROTEIN IN YEAST |
US7235648B1 (en) | 1993-03-31 | 2007-06-26 | Cadus Technologies, Inc. | Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor |
US6100042A (en) | 1993-03-31 | 2000-08-08 | Cadus Pharmaceutical Corporation | Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor |
US6255059B1 (en) | 1993-03-31 | 2001-07-03 | Cadus Pharmaceutical Corporation | Methods for identifying G protein coupled receptor effectors |
US5691365A (en) * | 1995-07-18 | 1997-11-25 | University Of Kentucky Research Foundation | Nicotinic receptor antagonists in the treatment of neuropharmacological disorders |
US6362009B1 (en) | 1997-11-21 | 2002-03-26 | Merck & Co., Inc. | Solid phase synthesis of heterocycles |
DE60233728D1 (en) * | 2001-06-06 | 2009-10-29 | Neurosearch As | CATION-LEADING GABA-A RECEPTORS AND THEIR USE |
NZ533259A (en) * | 2001-12-14 | 2007-10-26 | Targacept Inc | Methods and compositions for treatment of central nervous system disorders |
WO2005030145A2 (en) * | 2003-09-24 | 2005-04-07 | Targacept, Inc. | Composition and pharmacology of novel alpha-6-containing nicotinic acetylcholine receptors |
US7879913B2 (en) * | 2005-06-28 | 2011-02-01 | Catholic Healthcare West | Iptakalim hydrochloride for decreasing nicotine use |
US20070218456A1 (en) * | 2006-02-08 | 2007-09-20 | Invitrogen Corporation | Cellular assays for signaling receptors |
US9180191B2 (en) | 2009-10-16 | 2015-11-10 | University Of South Florida | Treatment of suicidal ideation or behavior using inhibitors of nicotinic acetylcholine receptors |
US9612240B2 (en) * | 2010-06-29 | 2017-04-04 | The Trustees Of The University Of Pennsylvania | Biomimetic chemical sensors using nanoelectronic readout of olfactory receptors |
US10983117B2 (en) | 2011-08-31 | 2021-04-20 | The Trustees Of The University Of Pennsylvania | Carbon nanotube biosensors and related methods |
WO2016036950A1 (en) | 2014-09-05 | 2016-03-10 | The Trustees Of The University Of Pennsylvania | Volatile organic compound-based diagnostic systems and methods |
Family Cites Families (17)
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---|---|---|---|---|
US4518527A (en) * | 1983-08-16 | 1985-05-21 | Mitsubishi Chemical Industries Limited | Polypeptides related to the pre-acetylcholine receptor-α of the electric organ of Torpedo californica |
US4837148A (en) * | 1984-10-30 | 1989-06-06 | Phillips Petroleum Company | Autonomous replication sequences for yeast strains of the genus pichia |
US4855231A (en) * | 1984-10-30 | 1989-08-08 | Phillips Petroleum Company | Regulatory region for heterologous gene expression in yeast |
US4882279A (en) * | 1985-10-25 | 1989-11-21 | Phillips Petroleum Company | Site selective genomic modification of yeast of the genus pichia |
US4859609A (en) * | 1986-04-30 | 1989-08-22 | Genentech, Inc. | Novel receptors for efficient determination of ligands and their antagonists or agonists |
US5071773A (en) * | 1986-10-24 | 1991-12-10 | The Salk Institute For Biological Studies | Hormone receptor-related bioassays |
US5024939A (en) * | 1987-07-09 | 1991-06-18 | Genentech, Inc. | Transient expression system for producing recombinant protein |
US4929555A (en) * | 1987-10-19 | 1990-05-29 | Phillips Petroleum Company | Pichia transformation |
US4981784A (en) * | 1987-12-02 | 1991-01-01 | The Salk Institute For Biological Studies | Retinoic acid receptor method |
ATE139542T1 (en) * | 1988-04-04 | 1996-07-15 | Salk Inst Biotech Ind | CALCIUM CHANNEL COMPOSITIONS AND METHODS |
US5386025A (en) * | 1990-02-20 | 1995-01-31 | The Salk Institute Biotechnology/Industrial Associates | Calcium channel compositions and methods |
DE69033214T2 (en) * | 1989-03-14 | 1999-12-09 | Salk Inst For Biolog Studies L | NEURONAL NICOTINE ACETYL CHOLINE RECEPTOR COMPOSITIONS CONTAINING THE BETA-4 SUB UNIT |
WO1991006677A1 (en) * | 1989-10-25 | 1991-05-16 | The Salk Institute For Biological Studies | Receptor infection assay |
US5091518A (en) * | 1989-11-16 | 1992-02-25 | The Salk Institute For Biological Studies | Beta retinoic acid response elements compositions and assays |
US5369028A (en) * | 1990-04-03 | 1994-11-29 | The Salk Institute Biotechnology/Industrial Associates, Inc. | DNA and mRNA encoding human neuronal nicotinic acetylcholine receptor compositions and cells transformed with same |
US5401629A (en) * | 1990-08-07 | 1995-03-28 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Assay methods and compositions useful for measuring the transduction of an intracellular signal |
GB2287941B (en) * | 1993-11-08 | 1998-01-28 | Salk Inst Biotech Ind | Human alpha2 neuronal nicotinic acetylcholine receptor compositions and methods employing same |
-
1990
- 1990-04-03 US US07/504,455 patent/US5369028A/en not_active Expired - Lifetime
-
1991
- 1991-04-03 DE DE69133135T patent/DE69133135T2/en not_active Expired - Fee Related
- 1991-04-03 US US07/938,154 patent/US5981193A/en not_active Expired - Fee Related
- 1991-04-03 CA CA002078572A patent/CA2078572C/en not_active Expired - Lifetime
- 1991-04-03 WO PCT/US1991/002311 patent/WO1991015602A1/en active IP Right Grant
- 1991-04-03 AT AT91908704T patent/ATE226247T1/en not_active IP Right Cessation
- 1991-04-03 ES ES91908704T patent/ES2183801T3/en not_active Expired - Lifetime
- 1991-04-03 EP EP91908704A patent/EP0523187B1/en not_active Expired - Lifetime
Non-Patent Citations (2)
Title |
---|
Nucleic Acids Research, Volume 18, No. 14, issued 1990, ANAND et al., "Nucleotide Sequence of the Human Nicotinic Acetylcholine Recepter Beta 2, Subunit Gene", page 4272. * |
The EMBO Journal, Volume 9, No. 7, issued 1990, BEESON et al. "The Human Muscle Nicotinic Acetylcholine Receptor Alpha-Subunit Exists as Two Isoforms: A Novel Exon", pages 2101-2106. * |
Cited By (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6440681B1 (en) | 1990-04-03 | 2002-08-27 | Merck & Co., Inc. | Methods for identifying agonists and antagonists for human neuronal nicotinic acetylcholine receptors |
US5981193A (en) * | 1990-04-03 | 1999-11-09 | Sibia Neurosciences, Inc. | Human neuronal nicotinic acetylcholine receptor compositions and methods employing same |
EP1586658A3 (en) * | 1990-08-07 | 2009-01-21 | Merck & Co., Inc. | Assay methods and compositions for detecting and evaluating the intracellular transduction of an extracellular signal |
EP1586658A2 (en) * | 1990-08-07 | 2005-10-19 | Merck & Co., Inc. | Assay methods and compositions for detecting and evaluating the intracellular transduction of an extracellular signal |
EP0542830B1 (en) * | 1990-08-07 | 2005-03-30 | Merck & Co., Inc. | Assay methods and compositions for detecting and evaluating the intracellular transduction of an extracellular signal |
US5436128A (en) * | 1990-08-07 | 1995-07-25 | Salk Institute Biotechnology/Industrial Associates | Assay methods and compositions for detecting and evaluating the intracellular transduction of an extracellular signal |
WO1993011257A2 (en) * | 1991-11-25 | 1993-06-10 | Boehringer Ingelheim International Gmbh | Process for screening substances capable of modulating a receptor-dependent cellular signal transmission path |
US5854004A (en) * | 1991-11-25 | 1998-12-29 | Boehringer Ingleheim Gmbh | Process for screening substances capable of modulating a receptor-dependent cellular signal transmission path |
WO1993011257A3 (en) * | 1991-11-25 | 1993-06-24 | Boehringer Ingelheim Int | Process for screening substances capable of modulating a receptor-dependent cellular signal transmission path |
US6372183B1 (en) | 1991-12-20 | 2002-04-16 | Merck & Co., Inc. | Automated analysis equipment and assay method for detecting cell surface protein and/or cytoplasmic receptor function using same |
US5670113A (en) * | 1991-12-20 | 1997-09-23 | Sibia Neurosciences, Inc. | Automated analysis equipment and assay method for detecting cell surface protein and/or cytoplasmic receptor function using same |
WO1993013423A1 (en) * | 1991-12-20 | 1993-07-08 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Automated analysis equipment and assay method for detecting cell surface protein and/or cytoplasmic receptor function using same |
US6057114A (en) * | 1991-12-20 | 2000-05-02 | Sibia Neurosciences, Inc. | Automated assays and methods for detecting and modulating cell surface protein function |
US6022704A (en) * | 1993-03-08 | 2000-02-08 | Sibia Neurosciences, Inc. | DNA and mRNA encoding an α4 subunit of human neuronal nicotinic acetylcholine receptor and cells transformed with same |
GB2286397A (en) * | 1993-03-08 | 1995-08-16 | Salk Inst Biotech Ind | Human neuronal nicotinic acetylcholine receptor compositions and methods employing same |
US5837489A (en) * | 1993-03-08 | 1998-11-17 | Sibia Neurosciences, Inc. | Human neuronal nicotinic acetylcholine receptor and cells transformed with same DNA and mRNA encoding an--subunit of |
WO1994020617A2 (en) * | 1993-03-08 | 1994-09-15 | The Salk Institute Biotechnology/Industrial Associates, Incorporated | Human neuronal nicotinic acetylcholine receptor compositions and methods employing same |
WO1994020617A3 (en) * | 1993-03-08 | 1994-10-27 | Salk Inst Biotech Ind | Human neuronal nicotinic acetylcholine receptor compositions and methods employing same |
EP1508614A1 (en) * | 1993-03-08 | 2005-02-23 | MERCK & CO. INC. | Human neuronal nicotinic acetylcholine receptor compositions and methods employing same |
US6303753B1 (en) | 1993-03-08 | 2001-10-16 | Merck & Co., Inc. | Human neuronal nicotinic acetylcholine receptor compositions and methods employing same |
GB2286397B (en) * | 1993-03-08 | 1997-09-10 | Salk Inst Biotech Ind | Human neuronal nicotinic acetylcholine receptor compositions and methods of employing same |
US5910582A (en) * | 1993-03-08 | 1999-06-08 | Sibia Neurosciences, Inc. | Human neuronal nicotinic acetylcholine receptor compositions and methods employing same |
US6664375B2 (en) | 1993-03-08 | 2003-12-16 | Kathryn J. Elliott | Human neuronal nicotinic acetylcholine receptor & subunit methods employing same |
US5801232A (en) * | 1993-11-08 | 1998-09-01 | Sibia Neuroscience, Inc. | DNA and mRNA encoding human neuronal nicotinic acetylcholine receptor alpha-2 subunit and cells transformed with same |
GB2287941B (en) * | 1993-11-08 | 1998-01-28 | Salk Inst Biotech Ind | Human alpha2 neuronal nicotinic acetylcholine receptor compositions and methods employing same |
WO1996003504A1 (en) * | 1994-07-21 | 1996-02-08 | The Salk Institute For Biological Studies | Cloning and expression of an acetylcholine-gated ion channel receptor subunit |
US6746864B1 (en) * | 1994-08-08 | 2004-06-08 | Science Applications International Corporation | Automated system for simultaneously performing a plurality of signal-based assays |
US7427380B2 (en) | 1994-08-08 | 2008-09-23 | Science Applications International Corporation | Automated system and method for simultaneously performing a plurality of signal-based assays |
US6777236B1 (en) | 1994-12-14 | 2004-08-17 | Institut Pasteur | Process for producing a neuronal host cell in vitro comprising regulatory sequences of the β2-subunit of the neuronal nicotinic acetylcholine receptor |
US6177242B1 (en) * | 1994-12-14 | 2001-01-23 | Institut Pasteur | Genomic DNA fragments containing regulatory and coding sequences for the β2-subunit of the neuronal nicotinic acetylcholine receptor and transgenic animals made using these fragments or mutated fragments |
US7294463B2 (en) | 1994-12-14 | 2007-11-13 | Institut Pasteur | Method of screening for compounds that modulate activity of a regulatory sequence of the β-2 subunit of a neuronal nicotinic acetylcholine receptor |
US6524789B1 (en) | 1995-06-07 | 2003-02-25 | Merck & Co., Inc. | Human neuronal nicotinic acetylcholine receptor compositions and methods employing same |
US6485967B1 (en) | 1995-06-07 | 2002-11-26 | Merck & Co., Inc. | Human neuronal nicotinic acetylcholine receptor α6 and β3 nucleic acid |
US6528630B1 (en) | 1997-12-03 | 2003-03-04 | Merck & Co., Inc. | Calcium channel compositions and methods |
US6632823B1 (en) | 1997-12-22 | 2003-10-14 | Merck & Co., Inc. | Substituted pyridine compounds useful as modulators of acetylcholine receptors |
WO2000024887A3 (en) * | 1998-10-27 | 2000-06-22 | Alfred Maelicke | Method for biotechnological production of ligand binding, especially extracellular, fragments of receptor subunits, especially neuroreceptors and hormone receptors |
WO2000024887A2 (en) * | 1998-10-27 | 2000-05-04 | Alfred Maelicke | Method for biotechnological production of ligand binding, especially extracellular, fragments of receptor subunits, especially neuroreceptors and hormone receptors |
US7700749B2 (en) | 2001-08-31 | 2010-04-20 | Agensys, Inc. | Nucleic acid and corresponding protein entitled 205P1B5 useful in treatment and detection of cancer |
Also Published As
Publication number | Publication date |
---|---|
CA2078572A1 (en) | 1991-10-04 |
EP0523187A4 (en) | 1994-04-06 |
DE69133135T2 (en) | 2003-06-18 |
US5369028A (en) | 1994-11-29 |
ATE226247T1 (en) | 2002-11-15 |
DE69133135D1 (en) | 2002-11-21 |
CA2078572C (en) | 2001-05-22 |
EP0523187B1 (en) | 2002-10-16 |
US5981193A (en) | 1999-11-09 |
ES2183801T3 (en) | 2003-04-01 |
EP0523187A1 (en) | 1993-01-20 |
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