WO1992007590A1 - Transdermal contraceptive formulations, methods and devices - Google Patents
Transdermal contraceptive formulations, methods and devices Download PDFInfo
- Publication number
- WO1992007590A1 WO1992007590A1 PCT/US1991/007984 US9107984W WO9207590A1 WO 1992007590 A1 WO1992007590 A1 WO 1992007590A1 US 9107984 W US9107984 W US 9107984W WO 9207590 A1 WO9207590 A1 WO 9207590A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- skin
- gestodene
- estrogen
- permeation enhancer
- reservoir
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU89562/91A AU657502B2 (en) | 1990-10-29 | 1991-10-25 | Transdermal contraceptive formulations, methods and devices |
JP4500145A JPH06502419A (en) | 1990-10-29 | 1991-10-25 | Transdermal contraceptive preparations, methods and devices |
NO93931208A NO931208L (en) | 1990-10-29 | 1993-03-31 | FORMULATIONS FOR TRANSDERMAL CONTRASE OPTIVES, AND PROCEDURES AND DEVICES FOR SUPPLYING SUCH |
FI931916A FI931916A0 (en) | 1990-10-29 | 1993-04-28 | TRANSMISSION PROCEDURE FOR FORMULATION, METHOD OF ANCHOR |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60558190A | 1990-10-29 | 1990-10-29 | |
US605,581 | 1990-10-29 | ||
US68125991A | 1991-04-08 | 1991-04-08 | |
US681,259 | 1991-04-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1992007590A1 true WO1992007590A1 (en) | 1992-05-14 |
Family
ID=27084986
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1991/007984 WO1992007590A1 (en) | 1990-10-29 | 1991-10-25 | Transdermal contraceptive formulations, methods and devices |
Country Status (11)
Country | Link |
---|---|
US (1) | US5376377A (en) |
EP (1) | EP0555360A1 (en) |
JP (1) | JPH06502419A (en) |
AU (1) | AU657502B2 (en) |
CA (1) | CA2091883A1 (en) |
FI (1) | FI931916A0 (en) |
IE (1) | IE913738A1 (en) |
MX (1) | MX9101787A (en) |
NZ (1) | NZ240358A (en) |
PT (1) | PT99338A (en) |
WO (1) | WO1992007590A1 (en) |
Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992020377A1 (en) * | 1991-05-20 | 1992-11-26 | Alza Corporation | Skin permeation enhancer compositions using glycerol monolinoleate |
EP0651993A1 (en) * | 1992-07-23 | 1995-05-10 | Hisamitsu Pharmaceutical Co., Inc. | Percutaneously administrable base composition and drug composition prepared therefrom |
WO1996003119A1 (en) * | 1994-07-26 | 1996-02-08 | Lavipharm S.A. | Transdermal delivery device containing an estrogen |
US5641504A (en) * | 1988-06-09 | 1997-06-24 | Alza Corporation | Skin permeation enhancer compositions using glycerol monolinoleate |
WO1998000118A2 (en) * | 1996-07-03 | 1998-01-08 | Alza Corporation | Drug delivery devices and process of manufacture |
US6007837A (en) * | 1996-07-03 | 1999-12-28 | Alza Corporation | Drug delivery devices and process of manufacture |
US6174545B1 (en) | 1997-07-01 | 2001-01-16 | Alza Corporation | Drug delivery devices and process of manufacture |
EP1541137A2 (en) * | 2003-12-12 | 2005-06-15 | Schering Aktiengesellschaft | Transdermal delivery system of hormones without penetration enhancers |
WO2005058287A2 (en) * | 2003-12-12 | 2005-06-30 | Schering Aktiengesellschaft | Transdermal delivery system of hormones without penetration enhancers |
US7611727B2 (en) | 2003-02-20 | 2009-11-03 | Besins International Belgique | Pharmaceutical composition for transdermal or transmucous administration |
DE102010040299A1 (en) | 2010-09-06 | 2012-03-08 | Bayer Schering Pharma Aktiengesellschaft | Transdermal therapeutic systems with crystallization-inhibiting protective film (release liner) |
WO2012031999A2 (en) | 2010-09-06 | 2012-03-15 | Bayer Pharma Aktiengesellschaft | Low-dose transdermal patches with high drug release |
US8486443B2 (en) | 2003-02-21 | 2013-07-16 | Bayer Ip Gmbh | UV stable transdermal therapeutic plaster with a UV absorbing adhesive layer separated from the drug matrix |
US8668925B2 (en) | 2003-12-12 | 2014-03-11 | Bayer Intellectual Property Gmbh | Transdermal delivery of hormones without the need of penetration enhancers |
US8962013B2 (en) | 2005-05-02 | 2015-02-24 | Bayer Intellectual Property Gmbh | Multi-layered transdermal system with triazine UV absorber |
US9125816B2 (en) | 2000-08-30 | 2015-09-08 | Besins Healthcare Inc. | Pharmaceutical composition and method for treating hypogonadism |
US10028858B2 (en) | 2011-07-11 | 2018-07-24 | Medicines360 | Intrauterine systems, IUD insertion devices, and related methods and kits therefor |
US10080760B2 (en) | 2009-10-27 | 2018-09-25 | Besins Healthcare Luxembourg Sarl | Transdermal pharmaceutical compositions comprising active agents |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5252334A (en) * | 1989-09-08 | 1993-10-12 | Cygnus Therapeutic Systems | Solid matrix system for transdermal drug delivery |
DE4329242A1 (en) * | 1993-08-26 | 1995-03-02 | Schering Ag | Agent for transdermal application containing gestodenester |
ES2190472T5 (en) * | 1995-06-07 | 2012-03-09 | Ortho-Mcneil Pharmaceutical, Inc. | TRANSDERMAL PATCH FOR THE ADMINISTRATION OF 17-DEACETIL NORGESTIMATO, IN COMBINATION WITH A STROGEN. |
US5785991A (en) * | 1995-06-07 | 1998-07-28 | Alza Corporation | Skin permeation enhancer compositions comprising glycerol monolaurate and lauryl acetate |
US5780050A (en) * | 1995-07-20 | 1998-07-14 | Theratech, Inc. | Drug delivery compositions for improved stability of steroids |
US6547343B1 (en) | 1997-09-08 | 2003-04-15 | General Motors Corporation | Brake system control |
USRE44145E1 (en) | 2000-07-07 | 2013-04-09 | A.V. Topchiev Institute Of Petrochemical Synthesis | Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties |
US8840918B2 (en) | 2001-05-01 | 2014-09-23 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Hydrogel compositions for tooth whitening |
US8541021B2 (en) | 2001-05-01 | 2013-09-24 | A.V. Topchiev Institute Of Petrochemical Synthesis | Hydrogel compositions demonstrating phase separation on contact with aqueous media |
US8206738B2 (en) | 2001-05-01 | 2012-06-26 | Corium International, Inc. | Hydrogel compositions with an erodible backing member |
ATE438418T1 (en) | 2001-05-01 | 2009-08-15 | Av Topchiev Inst Petrochemical | HYDROGEL COMPOSITIONS |
US20050113510A1 (en) | 2001-05-01 | 2005-05-26 | Feldstein Mikhail M. | Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components |
US20050215727A1 (en) | 2001-05-01 | 2005-09-29 | Corium | Water-absorbent adhesive compositions and associated methods of manufacture and use |
US6803420B2 (en) | 2001-05-01 | 2004-10-12 | Corium International | Two-phase, water-absorbent bioadhesive composition |
DE10159120B4 (en) * | 2001-12-01 | 2006-08-17 | Lts Lohmann Therapie-Systeme Ag | Steroid hormone-containing transdermal therapeutic systems containing propylene glycol monocaprylate and its use |
WO2005074894A1 (en) | 2004-01-30 | 2005-08-18 | Corium International | Rapidly dissolving film for delivery of an active agent |
CN103497713B (en) | 2004-08-05 | 2018-07-17 | 考里安国际公司 | Adhesive composition |
WO2006036899A2 (en) * | 2004-09-27 | 2006-04-06 | Corium International, Inc. | Transdermal systems for the delivery of estrogens and progestins |
AU2010204986B2 (en) | 2009-01-14 | 2016-06-02 | Corium International, Inc. | Transdermal administration of tamsulosin |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0279982A1 (en) * | 1987-02-26 | 1988-08-31 | Alza Corporation | Transdermal contraceptive formulations |
EP0370220A1 (en) * | 1988-10-27 | 1990-05-30 | Schering Aktiengesellschaft | Gestode composition for transdermal application |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3598123A (en) * | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
US3598122A (en) * | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
US3948262A (en) * | 1969-04-01 | 1976-04-06 | Alza Corporation | Novel drug delivery device |
US3710795A (en) * | 1970-09-29 | 1973-01-16 | Alza Corp | Drug-delivery device with stretched, rate-controlling membrane |
US4136145A (en) * | 1974-07-05 | 1979-01-23 | Schering Aktiengesellschaft | Medicament carriers in the form of film having active substance incorporated therein |
US4144317A (en) * | 1975-05-30 | 1979-03-13 | Alza Corporation | Device consisting of copolymer having acetoxy groups for delivering drugs |
US4081537A (en) * | 1975-10-10 | 1978-03-28 | Schering Aktiengesellschaft | Δ15 -Steroids and pharmaceutical compositions thereof |
US4291014A (en) * | 1979-01-11 | 1981-09-22 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing estradiol diacetate |
IL59063A (en) * | 1979-01-11 | 1983-12-30 | Key Pharma | Polymeric diffusion matrix for release of pharmaceutical dosage |
US4438139A (en) * | 1979-08-14 | 1984-03-20 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing estrogens |
US4286592A (en) * | 1980-02-04 | 1981-09-01 | Alza Corporation | Therapeutic system for administering drugs to the skin |
US4314557A (en) * | 1980-05-19 | 1982-02-09 | Alza Corporation | Dissolution controlled active agent dispenser |
US4379454A (en) * | 1981-02-17 | 1983-04-12 | Alza Corporation | Dosage for coadministering drug and percutaneous absorption enhancer |
ZA853488B (en) * | 1984-05-10 | 1986-12-30 | American Home Prod | Transdermal dosage form |
US4624665A (en) * | 1984-10-01 | 1986-11-25 | Biotek, Inc. | Method of transdermal drug delivery |
US4568343A (en) * | 1984-10-09 | 1986-02-04 | Alza Corporation | Skin permeation enhancer compositions |
US4818540A (en) * | 1985-02-25 | 1989-04-04 | Rutgers, The State University Of New Jersey | Transdermal fertility control system and process |
US4906169A (en) * | 1986-12-29 | 1990-03-06 | Rutgers, The State University Of New Jersey | Transdermal estrogen/progestin dosage unit, system and process |
CH674618A5 (en) * | 1987-04-02 | 1990-06-29 | Ciba Geigy Ag | |
US4863738A (en) * | 1987-11-23 | 1989-09-05 | Alza Corporation | Skin permeation enhancer compositions using glycerol monooleate |
DE3836862A1 (en) * | 1988-10-27 | 1990-05-03 | Schering Ag | Composition for the transdermal administration of steroid hormones |
-
1991
- 1991-10-25 WO PCT/US1991/007984 patent/WO1992007590A1/en not_active Application Discontinuation
- 1991-10-25 PT PT99338A patent/PT99338A/en not_active Application Discontinuation
- 1991-10-25 EP EP91920624A patent/EP0555360A1/en not_active Ceased
- 1991-10-25 IE IE373891A patent/IE913738A1/en not_active Application Discontinuation
- 1991-10-25 MX MX9101787A patent/MX9101787A/en unknown
- 1991-10-25 NZ NZ240358A patent/NZ240358A/en unknown
- 1991-10-25 AU AU89562/91A patent/AU657502B2/en not_active Ceased
- 1991-10-25 JP JP4500145A patent/JPH06502419A/en active Pending
- 1991-10-25 CA CA002091883A patent/CA2091883A1/en not_active Abandoned
-
1992
- 1992-12-17 US US07/994,055 patent/US5376377A/en not_active Expired - Lifetime
-
1993
- 1993-04-28 FI FI931916A patent/FI931916A0/en not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0279982A1 (en) * | 1987-02-26 | 1988-08-31 | Alza Corporation | Transdermal contraceptive formulations |
EP0370220A1 (en) * | 1988-10-27 | 1990-05-30 | Schering Aktiengesellschaft | Gestode composition for transdermal application |
Cited By (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5641504A (en) * | 1988-06-09 | 1997-06-24 | Alza Corporation | Skin permeation enhancer compositions using glycerol monolinoleate |
WO1992020377A1 (en) * | 1991-05-20 | 1992-11-26 | Alza Corporation | Skin permeation enhancer compositions using glycerol monolinoleate |
EP0651993A1 (en) * | 1992-07-23 | 1995-05-10 | Hisamitsu Pharmaceutical Co., Inc. | Percutaneously administrable base composition and drug composition prepared therefrom |
EP0651993A4 (en) * | 1992-07-23 | 1997-02-26 | Hisamitsu Pharmaceutical Co | Percutaneously administrable base composition and drug composition prepared therefrom. |
AU703074B2 (en) * | 1994-07-26 | 1999-03-11 | Lavipharm S.A. | Transdermal delivery device containing an estrogen |
WO1996003119A1 (en) * | 1994-07-26 | 1996-02-08 | Lavipharm S.A. | Transdermal delivery device containing an estrogen |
US5925373A (en) * | 1994-07-26 | 1999-07-20 | Lavipharm S.A. | Transdermal delivery device containing an estrogen |
WO1998000118A3 (en) * | 1996-07-03 | 1998-03-05 | Alza Corp | Drug delivery devices and process of manufacture |
WO1998000118A2 (en) * | 1996-07-03 | 1998-01-08 | Alza Corporation | Drug delivery devices and process of manufacture |
US6007837A (en) * | 1996-07-03 | 1999-12-28 | Alza Corporation | Drug delivery devices and process of manufacture |
US6174545B1 (en) | 1997-07-01 | 2001-01-16 | Alza Corporation | Drug delivery devices and process of manufacture |
US9132089B2 (en) | 2000-08-30 | 2015-09-15 | Besins Healthcare Inc. | Pharmaceutical composition and method for treating hypogonadism |
US9125816B2 (en) | 2000-08-30 | 2015-09-08 | Besins Healthcare Inc. | Pharmaceutical composition and method for treating hypogonadism |
US7611727B2 (en) | 2003-02-20 | 2009-11-03 | Besins International Belgique | Pharmaceutical composition for transdermal or transmucous administration |
US9095691B2 (en) | 2003-02-21 | 2015-08-04 | Bayer Intellectual Property Gmbh | UV stable transdermal therapeutic plaster with a UV absorbing self-adhesive layer separated from the drug matrix |
US8486443B2 (en) | 2003-02-21 | 2013-07-16 | Bayer Ip Gmbh | UV stable transdermal therapeutic plaster with a UV absorbing adhesive layer separated from the drug matrix |
EA011160B1 (en) * | 2003-12-12 | 2009-02-27 | Шеринг Акциенгезельшафт | A composition for transdermal delivery of hormones without penetration enhancers and its use |
EP1541137A3 (en) * | 2003-12-12 | 2005-11-16 | Schering Aktiengesellschaft | Transdermal delivery system of hormones without penetration enhancers |
EP2138169A2 (en) | 2003-12-12 | 2009-12-30 | Bayer Schering Pharma Aktiengesellschaft | Transdermal delivery system of hormones without penetration enhancers |
EP2138169A3 (en) * | 2003-12-12 | 2011-04-06 | Bayer Schering Pharma Aktiengesellschaft | Transdermal delivery system of hormones without penetration enhancers |
NO341989B1 (en) * | 2003-12-12 | 2018-03-12 | Bayer Ip Gmbh | Transdermal administration of hormones without the need for penetration enhancers. |
EP1541137A2 (en) * | 2003-12-12 | 2005-06-15 | Schering Aktiengesellschaft | Transdermal delivery system of hormones without penetration enhancers |
WO2005058287A2 (en) * | 2003-12-12 | 2005-06-30 | Schering Aktiengesellschaft | Transdermal delivery system of hormones without penetration enhancers |
US8668925B2 (en) | 2003-12-12 | 2014-03-11 | Bayer Intellectual Property Gmbh | Transdermal delivery of hormones without the need of penetration enhancers |
WO2005058287A3 (en) * | 2003-12-12 | 2006-03-02 | Schering Ag | Transdermal delivery system of hormones without penetration enhancers |
US9005653B2 (en) | 2003-12-12 | 2015-04-14 | Bayer Intellectual Property Gmbh | Transdermal delivery of hormones with low concentration of penetration enhancers |
US8962013B2 (en) | 2005-05-02 | 2015-02-24 | Bayer Intellectual Property Gmbh | Multi-layered transdermal system with triazine UV absorber |
US10080760B2 (en) | 2009-10-27 | 2018-09-25 | Besins Healthcare Luxembourg Sarl | Transdermal pharmaceutical compositions comprising active agents |
US11040043B2 (en) | 2009-10-27 | 2021-06-22 | Besins Healthcare Luxembourg Sarl | Transdermal pharmaceutical compositions comprising active agents |
WO2012031999A2 (en) | 2010-09-06 | 2012-03-15 | Bayer Pharma Aktiengesellschaft | Low-dose transdermal patches with high drug release |
WO2012031985A1 (en) | 2010-09-06 | 2012-03-15 | Bayer Pharma Aktiengesellschaft | Transdermal therapeutic systems with crystallization-inhibiting protective film (release liner) |
DE102010040299A1 (en) | 2010-09-06 | 2012-03-08 | Bayer Schering Pharma Aktiengesellschaft | Transdermal therapeutic systems with crystallization-inhibiting protective film (release liner) |
US10028858B2 (en) | 2011-07-11 | 2018-07-24 | Medicines360 | Intrauterine systems, IUD insertion devices, and related methods and kits therefor |
US11090186B2 (en) | 2011-07-11 | 2021-08-17 | Medicines360 | Methods for using intrauterine systems and IUD insertion devices |
Also Published As
Publication number | Publication date |
---|---|
IE913738A1 (en) | 1992-05-22 |
AU8956291A (en) | 1992-05-26 |
MX9101787A (en) | 1992-06-05 |
JPH06502419A (en) | 1994-03-17 |
AU657502B2 (en) | 1995-03-16 |
FI931916A (en) | 1993-04-28 |
CA2091883A1 (en) | 1992-04-30 |
NZ240358A (en) | 1994-09-27 |
PT99338A (en) | 1992-10-30 |
FI931916A0 (en) | 1993-04-28 |
EP0555360A1 (en) | 1993-08-18 |
US5376377A (en) | 1994-12-27 |
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