WO1992016181A3 - Composition for promoting tissue repair and regeneration - Google Patents

Composition for promoting tissue repair and regeneration Download PDF

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Publication number
WO1992016181A3
WO1992016181A3 PCT/US1992/002043 US9202043W WO9216181A3 WO 1992016181 A3 WO1992016181 A3 WO 1992016181A3 US 9202043 W US9202043 W US 9202043W WO 9216181 A3 WO9216181 A3 WO 9216181A3
Authority
WO
WIPO (PCT)
Prior art keywords
regeneration
composition
tissue repair
promoting tissue
tissue
Prior art date
Application number
PCT/US1992/002043
Other languages
French (fr)
Other versions
WO1992016181A2 (en
Inventor
Robert Bruce Rutherford
Marc F Charette
Original Assignee
Creative Biomolecules Inc
Univ Connecticut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Creative Biomolecules Inc, Univ Connecticut filed Critical Creative Biomolecules Inc
Priority to AT92908042T priority Critical patent/ATE196604T1/en
Priority to CA002106073A priority patent/CA2106073C/en
Priority to JP4507585A priority patent/JPH07505858A/en
Priority to EP92908042A priority patent/EP0575484B1/en
Priority to AU15591/92A priority patent/AU656372B2/en
Priority to DE69231486T priority patent/DE69231486T2/en
Publication of WO1992016181A2 publication Critical patent/WO1992016181A2/en
Publication of WO1992016181A3 publication Critical patent/WO1992016181A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Disclosed is a method for the regeneration of tissue, the treatment of external wounds and the treatment of periodontal disease comprising applying to the affected tissue an effective amount of a composition comprised of platelet-derived growth factor (PDGF) and an anti-inflammatory compound. The presence of the anti-inflammatory compound potentiates the activity of PDGF in stimulating cell growth, thereby enhancing tissue regeneration and/or wound healing.
PCT/US1992/002043 1991-03-12 1992-03-12 Composition for promoting tissue repair and regeneration WO1992016181A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AT92908042T ATE196604T1 (en) 1991-03-12 1992-03-12 COMPOSITION CONTAINING PDGF AND DEXAMETHASON FOR PROMOTING TISSUE REPAIR AND REGENERATION
CA002106073A CA2106073C (en) 1991-03-12 1992-03-12 Composition for promoting tissue repair and regeneration
JP4507585A JPH07505858A (en) 1991-03-12 1992-03-12 Methods for promoting tissue repair and regeneration
EP92908042A EP0575484B1 (en) 1991-03-12 1992-03-12 Composition comprising pdgf and dexamethasone for promoting tissue repair and regeneration
AU15591/92A AU656372B2 (en) 1991-03-12 1992-03-12 Composition for promoting tissue repair and regeneration
DE69231486T DE69231486T2 (en) 1991-03-12 1992-03-12 COMPOSITION CONTAINING PDGF AND DEXAMETHASONE TO PROMOTE TISSUE REPAIR AND REGENERATION

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/669,070 US5149691A (en) 1991-03-12 1991-03-12 Issue repair and regeneration through the use of platelet derived growth factor (pdgf) in combination with dexamethasone
US669,070 1991-03-12

Publications (2)

Publication Number Publication Date
WO1992016181A2 WO1992016181A2 (en) 1992-10-01
WO1992016181A3 true WO1992016181A3 (en) 1992-11-12

Family

ID=24684879

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1992/002043 WO1992016181A2 (en) 1991-03-12 1992-03-12 Composition for promoting tissue repair and regeneration

Country Status (8)

Country Link
US (2) US5149691A (en)
EP (1) EP0575484B1 (en)
JP (1) JPH07505858A (en)
AT (1) ATE196604T1 (en)
AU (1) AU656372B2 (en)
CA (1) CA2106073C (en)
DE (1) DE69231486T2 (en)
WO (1) WO1992016181A2 (en)

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US5770209A (en) * 1991-08-30 1998-06-23 University Of South Florida Acceleration of wound healing using connective tissue growth factor
US5837258A (en) * 1991-08-30 1998-11-17 University Of South Florida Induction of tissue, bone or cartilage formation using connective tissue growth factor
US7384634B2 (en) * 1991-08-30 2008-06-10 University Of South Florida Connective tissue growth factor
US5408040A (en) * 1991-08-30 1995-04-18 University Of South Florida Connective tissue growth factor(CTGF)
US5326695A (en) * 1992-05-15 1994-07-05 Ludwig Institute For Cancer Research Platelet derived growth factor agonists
US5444151A (en) * 1992-05-15 1995-08-22 Ludwig Institute For Cancer Research Platelet derived growth factor antagonists
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US5455041A (en) * 1993-09-13 1995-10-03 Research Foundation Of State University Of New York At Buffalo Method for inducing periodontal tissue regeneration
US5942496A (en) * 1994-02-18 1999-08-24 The Regent Of The University Of Michigan Methods and compositions for multiple gene transfer into bone cells
US6551618B2 (en) 1994-03-15 2003-04-22 University Of Birmingham Compositions and methods for delivery of agents for neuronal regeneration and survival
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DE19754140A1 (en) * 1997-12-05 1999-06-24 Era Beschichtung Gmbh & Co Kg Interior material based on plastic, process for its production and use
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US7847087B2 (en) 2001-03-05 2010-12-07 Siemens Healthcare Diagnostics Inc. Methods and primers for evaluating HIV-1 mutations
WO2003103691A1 (en) * 2001-06-07 2003-12-18 Chiou Consulting, Inc. Compositions and methods for the prophylaxis and treatment of aphthous ulcers and herpes simplex lesions
US7819888B2 (en) * 2001-10-23 2010-10-26 Innovasive Devices, Inc. Method and apparatus for harvesting and implanting bone plugs
DE10152956A1 (en) * 2001-10-26 2003-05-15 Fresenius Kabi De Gmbh A pharmaceutical composition comprising a growth factor and / or a cytokine and an antiseptic biguanide
WO2003094937A1 (en) 2002-05-09 2003-11-20 Medigenes A pharmaceutical composition for treatment of wounds containing blood plasma or serum
US6616923B1 (en) * 2002-07-26 2003-09-09 Chiou Consulting, Inc. Aqueous compositions for facial cosmetics
US20040018220A1 (en) * 2002-07-26 2004-01-29 Chiou Consulting, Inc. Aqueous compositions for facial cosmetics
ATE510605T1 (en) 2003-03-14 2011-06-15 Univ Columbia SYSTEMS AND METHODS FOR BLOOD BASED THERAPY USING A MEMBRANELESS MICROFLUID EXCHANGE DEVICE
US20060076295A1 (en) 2004-03-15 2006-04-13 The Trustees Of Columbia University In The City Of New York Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
US7309232B2 (en) * 2003-10-10 2007-12-18 Dentigenix Inc. Methods for treating dental conditions using tissue scaffolds
US7258875B2 (en) * 2003-12-04 2007-08-21 Chiou Consulting, Inc. Compositions and methods for topical treatment of skin infection
US8293890B2 (en) * 2004-04-30 2012-10-23 Advanced Cardiovascular Systems, Inc. Hyaluronic acid based copolymers
GB0414803D0 (en) * 2004-07-01 2004-08-04 Glaxo Group Ltd Composition
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
US20060115266A1 (en) * 2004-12-01 2006-06-01 Gil Levi All-optical protection signaling systems and methods in optical communication networks
AU2006275444B2 (en) * 2005-08-01 2010-10-28 Genera Istrazivanja D.O.O. Methods and compositions for regenerating articular cartilage
NZ571113A (en) 2005-11-17 2012-02-24 Biomimetic Therapeutics Inc Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix
WO2007083853A1 (en) 2006-01-23 2007-07-26 Imagene Co., Ltd. Novel peptide and use thereof
EP2311505B1 (en) * 2006-02-09 2013-11-06 BioMimetic Therapeutics, LLC Compositions and methods for treating bone
MX2008014732A (en) 2006-05-22 2009-04-07 Univ Columbia Systems and methods of microfluidic membraneless exchange using filtration of extraction fluid outlet streams.
US9642891B2 (en) 2006-06-30 2017-05-09 Biomimetic Therapeutics, Llc Compositions and methods for treating rotator cuff injuries
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
AU2013203287B2 (en) * 2006-11-03 2015-12-17 Biomimetic Therapeutics, Llc. Compositions and methods for arthrodetic procedures
EP3181157B1 (en) 2006-11-03 2019-08-14 BioMimetic Therapeutics, LLC Compositions and methods for arthrodetic procedures
US9511076B2 (en) * 2008-05-30 2016-12-06 Clarion Research Group Formulations and methods for recovery from dental surgery
US8282963B2 (en) * 2007-10-15 2012-10-09 The Regents Of The University Of Colorado, A Body Corporate Methods for extracting platelets and compositions obtained therefrom
MX2010007442A (en) 2008-01-07 2010-12-21 Vereniging Voor Christelijk Hoger Onderwijs Wetenschappelijk Onderzoek En Patientenzorg Use of peptides for promoting wound healing.
CA2714594A1 (en) 2008-02-04 2009-08-13 Edward F. Leonard Fluid separation devices, systems and methods
US7943573B2 (en) 2008-02-07 2011-05-17 Biomimetic Therapeutics, Inc. Methods for treatment of distraction osteogenesis using PDGF
BR122020000059B8 (en) 2008-09-09 2021-06-22 Biomimetic Therapeutics Inc composition comprising a biocompatible matrix and a platelet-derived growth factor and kit
US20120100111A1 (en) * 2009-03-06 2012-04-26 Universite Paris Descartes Method for treating cancer
JP6144049B2 (en) 2010-02-22 2017-06-07 バイオミメティック セラピューティクス，リミテッド ライアビリティ カンパニー Platelet-derived growth factor compositions and methods for treating tendon disorders
AU2011267081A1 (en) 2010-06-14 2013-01-17 Gene Signal International Sa Novel peptides for wound healing
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KR20180059953A (en) 2010-07-12 2018-06-05 에이티와이알 파마, 인코포레이티드 Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-trna synthetases
US20130108683A1 (en) * 2011-10-25 2013-05-02 Biomimetic Therapeutics, Inc. Compositions and methods for treating partial and full thickness wounds and injuries
CA2864300A1 (en) 2012-02-16 2013-08-22 Atyr Pharma, Inc. Histidyl-trna synthetases for treating autoimmune and inflammatory diseases
DK3460054T3 (en) 2013-03-15 2021-01-18 Atyr Pharma Inc Histidyl-tRNA-synthetase-Fc conjugates
EP3206670A4 (en) 2014-10-14 2018-06-20 Samuel Lynch Compositions for treating wounds
CN110536694A (en) 2017-04-20 2019-12-03 Atyr 医药公司 For treating pulmonary inflammatory composition and method
KR20200060997A (en) 2018-11-23 2020-06-02 (주)메디코스바이오텍 Pharmaceutical Composition for Treatment of Wounds
CZ308845B6 (en) 2019-01-21 2021-07-07 Globetech Innovation S.R.O Pharmaceutical composition of topically healing peptide components for use in the topical treatment of skin defects and / or for topical wound healing
PL433169A1 (en) 2020-03-06 2021-09-13 Gdański Uniwersytet Medyczny Lipopeptide conjugates and their salts, method for the preparation thereof, pharmaceutical composition containing a lipopeptide conjugate and its salts for the treatment of chronic wounds

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WO1988004180A1 (en) * 1986-12-11 1988-06-16 National Research Development Corporation Improvements in or relating to the use of epidermal growth factor

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Also Published As

Publication number Publication date
JPH07505858A (en) 1995-06-29
ATE196604T1 (en) 2000-10-15
DE69231486D1 (en) 2000-11-02
US5376636A (en) 1994-12-27
WO1992016181A2 (en) 1992-10-01
EP0575484B1 (en) 2000-09-27
US5149691A (en) 1992-09-22
CA2106073A1 (en) 1993-09-13
AU1559192A (en) 1992-10-21
DE69231486T2 (en) 2001-04-26
CA2106073C (en) 2003-09-30
EP0575484A1 (en) 1993-12-29
AU656372B2 (en) 1995-02-02

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