WO1992021302A1 - An implant - Google Patents
An implant Download PDFInfo
- Publication number
- WO1992021302A1 WO1992021302A1 PCT/SE1992/000366 SE9200366W WO9221302A1 WO 1992021302 A1 WO1992021302 A1 WO 1992021302A1 SE 9200366 W SE9200366 W SE 9200366W WO 9221302 A1 WO9221302 A1 WO 9221302A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- implant
- pores
- interval
- pore size
- volume
- Prior art date
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F7/00—Manufacture of composite layers, workpieces, or articles, comprising metallic powder, by sintering the powder, with or without compacting wherein at least one part is obtained by sintering or compression
- B22F7/002—Manufacture of composite layers, workpieces, or articles, comprising metallic powder, by sintering the powder, with or without compacting wherein at least one part is obtained by sintering or compression of porous nature
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
-
- A—HUMAN NECESSITIES
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
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- A—HUMAN NECESSITIES
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
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- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0018—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the shape
- A61C8/0037—Details of the shape
- A61C2008/0046—Textured surface, e.g. roughness, microstructure
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- A—HUMAN NECESSITIES
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- A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
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- A—HUMAN NECESSITIES
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- A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
- A61C8/0016—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy polymeric material
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/32—Joints for the hip
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
- A61F2002/30011—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in porosity
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30317—The prosthesis having different structural features at different locations within the same prosthesis
- A61F2002/30322—The prosthesis having different structural features at different locations within the same prosthesis differing in surface structures
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00185—Ceramics or ceramic-like structures based on metal oxides
- A61F2310/00233—Ceramics or ceramic-like structures based on metal oxides containing chromia or chromium oxides CrO, CrO2 or CrO3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00269—Ceramics or ceramic-like structures based on metal carbides
- A61F2310/00281—Ceramics or ceramic-like structures based on metal carbides containing silicon carbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00299—Ceramics or ceramic-like structures based on metal nitrides
- A61F2310/00317—Ceramics or ceramic-like structures based on metal nitrides containing silicon nitride
Definitions
- the present invention relates to the field of chiefly medical appli ⁇ cations, more specificly to the field of implantology, and relates to an implant made of a porous, not toxic material having a total open porosity of more than 5 percent by volume but not more than 80 percent by volume within at least a portion of the implant.
- pores are also required, which are designed to allow a generally favorable situation for bone ingrowth and/or tissue ingrowth with an integrated interaction of soft and hard tissues. Pores can also be used as reservoirs for soluble substances, deposited in the material and having specific, often medical/biological functions. Examples are deposited substances, which function as a calcium or phophorus source, containing bone growth factors or containing prophylactic or anti-inflammatory agents. The porosity then can be an excellent space for slow-release processes.
- porous materials are used in implant techniques.
- the introduction of pores results in a dramatic strength reduction of the implant. This is particularly true in brittle mate ⁇ rials having a low fracture strength.
- Fracture mechanical correlations indicate the size of the strength reduction for such materials with the following expression of fracture strength for such materials, also
- Y is a geometric position and shape factor
- ⁇ is the fracture strength
- c indicate the highest allowable defect
- New construction cerams e.g. based on silicon nitride or zirconium oxide, are more- suitable for such highly stressed applications.
- a ceramic material which is able to retain a relatively high strength despite the presence of a large amount of pores, is reaction bound silicon nitride, Si N (RBSN).
- Si N reaction bound silicon nitride
- RBSN reaction bound silicon nitride
- a balance must be attained between on the one hand the porosity and the properties of the pores and on the other hand the strength requirement.
- the object of the present invention is to provide an implant of the type set forth in the preamble, which is able to combine a high strength and a capacity to meet high requirements as to a favorable situation for bone ingrowth as well as tissue ingrowth with an inte ⁇ grated interaction between soft and hard tissues, as well as to pro- vide reservoirs for substances to be deposited in the material and having specific functions.
- communicating pores having a pore size of 0.1-10 ⁇ m are to occupy 10-80 % of the total pore volume of said at least one portion of the material; pores having a pore size of 10-50 ⁇ m are to occupy not more than 5 % of the total pore volume of said portion of the material; and 5-40 % of the surface of said least one portion of the implant is to be covered by mainly evenly distributed pores having a pore size of 50-500 ⁇ m.
- said communicating pores with a pore size of 0.1-10 ⁇ m occupy 25-75 %, suitably 40-60 %, of the total pore volume in said at least one portion of the implant material.
- the main part, calculated as to the volume, of the above- mentioned communicating pores have a pore size of 0.3-8 ⁇ m, suitably 0.5-5 ⁇ m.
- the main part of the large pores in the surface layer preferably have a size of 75-400 ⁇ m, better 100-300 ⁇ m and best of all 150-250 ⁇ m.
- the material mainly has nil - or at least contains only a minor amount of - pores of 10-50 ⁇ m, large pores may nevertheless, provided the strength requirements are moderate, according to another embodiment of the invention exist in the interior of the material.
- Pore size is defined, as regards pores with pore sizes which are less than or is equal to 50 ⁇ m, as sizes determined by means of conven- tional Hg-porosimetry, the ratio between pore diameter (2r) being cal ⁇ culated by the formula:
- Pore sizes which are larger than 50 ⁇ m, are defined as sizes obtained through an optical determination in a light microscope on a cross- section of the test specimens, in a cut made 0.1 ⁇ m below the surface lf - and in a cut transversely to the test specimen surface respectively. Also, the expression "the total pore volume in the material” is defined as that pore volume, which is measured through a water pene ⁇ tration.
- the present invention is characterized by complicated pore size distributions, which will allow optimal combinations of strength and soft tissue-formations as well as a favorable bone ingrowth.
- the large pores generally are conducive to bone ingrowth, whereas the small pores are conducive to soft tissue-formations, but the latter
- pores can also act as reservoirs for soluble substances, deposited in the material and having specific medical/biological functions.
- the large as well as the small pores must be present in the surface of the implant, at least in a portion of the surface, in
- the small pores belong to a communi ⁇ cating pore system, designed to act as said reservoirs for deposited substances, e.g. substances which contain calcium and/or P0 , pre ⁇
- a calcium phosphate material e.g. hydroxyl apatite, bone growth stimulating hormones, anti-inflammatory agents etc.
- the implant is made, according to the present invention, of powders, _,,- which are consolidated to a porous body, which process can be done according to any method known per se, e.g. a conventional sintering, a cold pressing and subsequently a hot isostatic pressing or through nitridizing or the like.
- a material consisting of silicon nitride preferably is made by nitridizing silicon grains, a so called reaction bound silicon nitride (RBSN), Si N being obtained.
- RBSN reaction bound silicon nitride
- the material can also contain other substances than Si_N , but if Si N is chosen, this material ought to be present in an amount of at least 80 percent by weight.
- Other feasible materials are calcium phosphate ma ⁇ terials, e.g. hydroxyl apatite, Al 0 conflict, titanium, SiC, ZrO , chromium,
- the implant can completely consist of any of these materials or of mix ⁇ tures of two or several of these materials or mainly consist of any of these materials in combination with some additional materials, not mentioned in this text. Also, it ought to be mentioned, that the implant can have a different composition in different parts, one part being porous according to the invention, whereas another part consists of a more conventional material and is essentially pore-free. Combina ⁇ tions of portions having different compositions but each one of the portions being porous according to the inventive idea are also feasible.
- the porosity and the pore size distribution of the material can be controlled by means of any or several of the following methods:
- the finer pore fraction is obtained by controlling 1) and 2) above.
- an RBSN-material e.g. the size of the original
- Si-grains is decisive for the pore size of the fine pore fraction and its distribution in a formed reaction bound silicon nitride (RBSN), whereas the larger pores in the surface preferably are obtained through the final treatment according to 4) above.
- RBSN formed reaction bound silicon nitride
- this can be done by an admixture in the raw material of fibers, e.g. of a polymer, a ceram or a metal, which are burned off or leached off before or after the consolidation of the material.
- glass fibers can be added, which can be used as sintering agents or be removed before or after the consolidation.
- a laser process and/or an ultrasound process or a water jet cutting process are par ⁇ ticularly useful.
- pores having a particularly favorable pore profile can be obtained, which reduces the tension concentrations around the pores.
- combinations of a fine porosity and a coarse (macro-) porosity can be obtained through some sintering process, which is not completed and is followed by a surface treatment, e.g. through some of the techniques described above, in order to obtain a macrosurface porosity.
- Fig. 1 shows a shoulder prosthesis with a portion consisting of a porous material according to the invention
- Fig. 2 shows a hip joint prosthesis, in which also a portion consists of a porous material according to the invention
- Fig. 3 shows a dental implant, designed to fasten teeth in a bone, which implant also has a porous portion according to the invention
- Fig. 4-7 schematicly show how surface macropores present in the material may be designed
- Fig. 8 is a diagram, which shows the transverse force required to discharge an implant as a function of the ingrowth time.
- Fibers consisting of pieces, 1-2 mm, of a nylon cord having a diameter of 0.2 mm are added to a powder mixture comprising zirconium oxide and 3 percent by volume yttrium oxide. The amount of fibers is 12 percent by volume.
- the mixture is rumbled for 2 hours in a roller-type ball mill with a polymer container and spherical crushing balls made of zirconium oxide.
- Raw compacts are made through cold pressing at a pressure of 250 MPa. The raw compacts are heat treated in order to evaporate the organic component, i.e. the nylon fibers. The evapora ⁇ tion is done by elevating the temperature 5°C/hour up to 500°C.
- the relatively brittle raw compact which is obtained is sintered at 1550°C for 3 h.
- Hg-porosimetry shows pores with a size of about 1 ⁇ m.
- An optical examination in a light microscope of a cross-section shows a presence of large pores with a size of about 170 ⁇ m.
- the densifica- tion (compression) is done at 1150°C for 20 min.
- the maximum pressure at the highest temperature is 160 MPa.
- the porosity is measured through a water penetration and is 14.5 percent by volume. Hg- porosimetry shows that the main part, i.e. >90 % of the pores is within the interval of 0.4-0.7 ⁇ m with a mean pore size of 0.6 ⁇ m, whereas ⁇ 3 % of the total pore volume is within the interval 10-50 ⁇ m.
- a silicon raw material comprising a silicon powder called Sicomill 4D methyl alcohol is added. Subsequent to a careful rumbling grains larger than 5 ⁇ m are separated through a sedimentation. Thus, the remaining silicon raw material comprises powders with grain sizes ⁇ 5 ⁇ m.
- a raw compact with the dimensions 10 x 5 x 30 mm is made through a cold isostatic pressing with 3 percent by volume poly ⁇ ethylene glycol as a lubricant. The evaporation of PEG is done through a heating with about 10°C/hour up to 400°C.
- the raw compact is nitridized with a nitrogen gas containing atomosphere in two steps at 1160°C for 5 h and at 1400°C for 15 h, a reaction bound silicon nitride, Si K (RBSN) being obtained.
- the nitridized specimen has a 22 percent by volume open (communicating) porosity, measured through a vacuum suction and a water penetration.
- Hg-porosimetry shows a very narrow pore size distribution with >90 % of the total pore volume in the interval of 0.2-1.0 ⁇ m and with ⁇ 3 % in the interval of 10-50 ⁇ m.
- the pores in the interval of 0.2-1.0 ⁇ m the main part is more exactly within the interval of 0.2-0.4 ⁇ m.
- glass fibers made of CaAl-silicates, cemented to a diameter of 150 ⁇ m and having a length of 1-2 mm are added to a silicon nitride raw material called UBE E10.
- UBE E10 silicon nitride raw material
- the mixture is homoge ⁇ nized and raw compacts are made in the same way as in Example 1.
- Specimens are made through a sintering of the raw compacts at 1800°C for 2 h in a nitrogen gas atmosphere in a powder bed of coarse silicon nitride.
- the total porosity of the specimens is measured through a water penetration to 11 percent by volume.
- An optical examination in a light microscope shows a coarse fraction of pores having a size of about 150 ⁇ m.
- the mean value 350 indicates that the Y-value in the equation
- Raw compacts from Example 3 are provided with surface macropores having a size of about 200 ⁇ m, obtained by treating the surface with a stamp having densely distributed outwardly projecting nails, called a "nail mat".
- the nails have a central distance of 400 ⁇ m and produce an impression with a depth of 200 ⁇ m.
- the profile of the impressions is shown in Fig. 7. Subsequently the specimens are nitridized in the same way as in Example 3.
- the mean strength of the material, without surface macropores, which is made according to Example 3, determined through a 4-point bending test, is 290 MPa.
- a material with surface macropores, made according to Example 1 has a strength of 150 MPa, determined according to the same 4-point bending test.
- This example relates to a method of producing the material according to the invention.
- Specimens consisting of sintered zirconium oxide with 3 percent by volume yttrium oxide and having a density of 6.07 g/cm 3 are surface treated with ultrasound, a boron carbide slurry/slamma with a grain size of about 30 ⁇ m being used.
- Ultrasound tools with varying topography which corresponds to pore configura ⁇ tions according to Figs. 4 and 6, are used.
- a computer-controlled laser cutting can be used for the production of surface macropores on three implant components within areas, which when the implant is used are subjected to a low mechanical stress.
- the material within these areas consists of porous materials according to the invention and has been shaded in Figs. 1-3. These components are:
- hip joint component main, stem, Fig. 2;
- the remaining parts of the implants i.e. the non-shaded, more highly stressed portions, can consist of materials, which are more conven ⁇ tional implant materials, or also of other unconventional materials, which meet the specific requirements for these parts of the respective implant.
- Cylinders with a diameter of 2.8 mm and a length of 7 mm are produced from materials with surface macropores, described in Examples 3, 5, 6 and 7. These cylinders are inserted in a thigh bone in a rabbit. After three months the animals are killed and the necessary transverse forces for a discharge of the cylinders are determined with a so called push-out test. The results are compiled in Table 1:
- the configuration of the surface macropores corresponds to what is shown in Fig. 5.
- Ca-phosphate is precipita- ted by reaction between calcium hydroxide and ammonium phosphate.
- other bone growth stimulating agents can be added to the fine pore-structure, e.g.
- a bone growth factor or anti-inflammatory agents e.g. through a freeze dehydration process.
- Cylinders which are produced and treated in this way, are implanted in a thigh bone in rabbits. The animals are killed after 2, 5 and 8 weeks. Reference material without any Ca-phosphate deposit.
- the transverse forces between an implant and a new growth of bone is determined by a push- out testing. The results are shown in Fig. 8, which shows the trans ⁇ verse force as a function of the ingrowth time (weeks).
Abstract
The present invention relates to an implant made of a porous non-toxic material with a total open porosity larger than 5 percent by volume but not larger than 80 percent by volume within at least a portion of the implant. The implant is characterized in that: communicating pores with a pore size within the interval of 0.1-10 νm occupy 10-80 percent of the total pore volume in said at least one portion of the implant; pores with a pore size within the interval of 10-50 νm occupy not more than 5 % of the total pore volume in said at least one portion of the implant; and 5-40 % of at least one portion of the surface of the implant is covered by mainly evenly distributed pores having a pore size within the interval of 50-500 νm.
Description
An implant
The present invention relates to the field of chiefly medical appli¬ cations, more specificly to the field of implantology, and relates to an implant made of a porous, not toxic material having a total open porosity of more than 5 percent by volume but not more than 80 percent by volume within at least a portion of the implant.
BACKGROUND ART
In materials selected to be used in various types of supporting implants a minimum of pores, particularly large pores, is desirable as far as the strength is concerned. However, pores are also required, which are designed to allow a generally favorable situation for bone ingrowth and/or tissue ingrowth with an integrated interaction of soft and hard tissues. Pores can also be used as reservoirs for soluble substances, deposited in the material and having specific, often medical/biological functions. Examples are deposited substances, which function as a calcium or phophorus source, containing bone growth factors or containing prophylactic or anti-inflammatory agents. The porosity then can be an excellent space for slow-release processes.
Hence, in spite of the strength reducing effect of the porosity, porous materials are used in implant techniques. However, for many materials the introduction of pores results in a dramatic strength reduction of the implant. This is particularly true in brittle mate¬ rials having a low fracture strength. Fracture mechanical correlations indicate the size of the strength reduction for such materials with the following expression of fracture strength for such materials, also
1/2 called the critical tension intensity factor (MPam ):
1/2
= Y
'IC (1)
in which Y is a geometric position and shape factor, σ is the fracture strength and c indicate the highest allowable defect.
In conventional materials for implant applications, e.g. aluminum oxide and hydroxyl apatite having fracture strength values of 3.0 and
1/2 1.0 MPam respectively, e.g. a pore having a size of 200 μm results
in a maximum strength level about 150 and 40 MPa respectively, which implies that these two implant materials are questionable in mechani¬ cally highly stressed applications. There is also a risk that a slow fracture growth will occur, particularly for hydroxyl apatite, which means that tolerable stresses may very well be lower than the stated values.
New construction cerams, e.g. based on silicon nitride or zirconium oxide, are more- suitable for such highly stressed applications. A ceramic material, which is able to retain a relatively high strength despite the presence of a large amount of pores, is reaction bound silicon nitride, Si N (RBSN). However, also in these construction cerams as well as in other feasible implant materials, such as steel, titanium and other metals, polymers as well as in other oxidized or non-oxidized cerams, a balance must be attained between on the one hand the porosity and the properties of the pores and on the other hand the strength requirement.
BRIEF DISCLOSURE OF THE INVENTION The object of the present invention is to provide an implant of the type set forth in the preamble, which is able to combine a high strength and a capacity to meet high requirements as to a favorable situation for bone ingrowth as well as tissue ingrowth with an inte¬ grated interaction between soft and hard tissues, as well as to pro- vide reservoirs for substances to be deposited in the material and having specific functions. These and other objects can be attained according to the present invention by meeting the following require¬ ments: communicating pores having a pore size of 0.1-10 μm are to occupy 10-80 % of the total pore volume of said at least one portion of the material; pores having a pore size of 10-50 μm are to occupy not more than 5 % of the total pore volume of said portion of the material; and 5-40 % of the surface of said least one portion of the implant is to be covered by mainly evenly distributed pores having a pore size of 50-500 μm.
Preferably said communicating pores with a pore size of 0.1-10 μm occupy 25-75 %, suitably 40-60 %, of the total pore volume in said at least one portion of the implant material.
Preferably the main part, calculated as to the volume, of the above- mentioned communicating pores have a pore size of 0.3-8 μm, suitably 0.5-5 μm.
Preferably 10-30 %, suitably 15-25 % of the surface within said at least one portion of the implant is covered by the mainly evenly distributed pores having a pore size of 50-500 μm.
The main part of the large pores in the surface layer preferably have a size of 75-400 μm, better 100-300 μm and best of all 150-250 μm.
The large pores exist, according to one embodiment, only in a surface layer of the implant, namely a surface layer, which has a thickness of 3 mm, preferably 2 mm and suitably 0.3 mm.
Although the material mainly has nil - or at least contains only a minor amount of - pores of 10-50 μm, large pores may nevertheless, provided the strength requirements are moderate, according to another embodiment of the invention exist in the interior of the material. According to this aspect of the invention larger pores with a pore size of 50-500 μm, preferably 75-400 μm, more suitably 100-300 μm and best of all 150-250 μm occupy 10-80 % of the total pore volume.
Pore size is defined, as regards pores with pore sizes which are less than or is equal to 50 μm, as sizes determined by means of conven- tional Hg-porosimetry, the ratio between pore diameter (2r) being cal¬ culated by the formula:
2 s cos F . .. . p = , in which
p = the pressure s = the surface tension of Hg at the used temperature
F = meniscus angle (edge angle)
(reference: L.C. Ritter och R.L. Drake, Ind. Eng. Chem.
17782 (1945).) o —
Pore sizes, which are larger than 50 μm, are defined as sizes obtained through an optical determination in a light microscope on a cross- section of the test specimens, in a cut made 0.1 μm below the surface lf- and in a cut transversely to the test specimen surface respectively. Also, the expression "the total pore volume in the material" is defined as that pore volume, which is measured through a water pene¬ tration.
15 Thus, the present invention is characterized by complicated pore size distributions, which will allow optimal combinations of strength and soft tissue-formations as well as a favorable bone ingrowth.
The large pores generally are conducive to bone ingrowth, whereas the small pores are conducive to soft tissue-formations, but the latter
20 pores can also act as reservoirs for soluble substances, deposited in the material and having specific medical/biological functions. In order to allow a favorable bone ingrowth and a soft tissue-formation respectively the large as well as the small pores must be present in the surface of the implant, at least in a portion of the surface, in
25 which it is desirable that said functions are to be active. Also, throughout the entire material the small pores belong to a communi¬ cating pore system, designed to act as said reservoirs for deposited substances, e.g. substances which contain calcium and/or P0 , pre¬
30 ferably in the form of a calcium phosphate material, e.g. hydroxyl apatite, bone growth stimulating hormones, anti-inflammatory agents etc.
The implant is made, according to the present invention, of powders, _,,- which are consolidated to a porous body, which process can be done according to any method known per se, e.g. a conventional sintering,
a cold pressing and subsequently a hot isostatic pressing or through nitridizing or the like. Thus, e.g. a material consisting of silicon nitride preferably is made by nitridizing silicon grains, a so called reaction bound silicon nitride (RBSN), Si N being obtained. The material can also contain other substances than Si_N , but if Si N is chosen, this material ought to be present in an amount of at least 80 percent by weight. Other feasible materials are calcium phosphate ma¬ terials, e.g. hydroxyl apatite, Al 0„, titanium, SiC, ZrO , chromium,
__. __- cobalt steel, high-alloy stainless steels, and certain polymers. The implant can completely consist of any of these materials or of mix¬ tures of two or several of these materials or mainly consist of any of these materials in combination with some additional materials, not mentioned in this text. Also, it ought to be mentioned, that the implant can have a different composition in different parts, one part being porous according to the invention, whereas another part consists of a more conventional material and is essentially pore-free. Combina¬ tions of portions having different compositions but each one of the portions being porous according to the inventive idea are also feasible.
The porosity and the pore size distribution of the material can be controlled by means of any or several of the following methods:
1) through a selection of the original grain size of the raw material;
2) through a regulation of process parameters, pressure, temperature and time during the consolidation (densification) ;
3) through admixtures to gases or to the raw material; and
4) through a final treatment.
Thus, the finer pore fraction is obtained by controlling 1) and 2) above. Regarding an RBSN-material, e.g. the size of the original
Si-grains is decisive for the pore size of the fine pore fraction and its distribution in a formed reaction bound silicon nitride (RBSN), whereas the larger pores in the surface preferably are obtained through the final treatment according to 4) above. In case it is desirable, instead or in combination with larger pores obtained through a final treatment of the surface, to also obtain larger pores' in the main part of the material, this can be done by an admixture in
the raw material of fibers, e.g. of a polymer, a ceram or a metal, which are burned off or leached off before or after the consolidation of the material. Also, glass fibers can be added, which can be used as sintering agents or be removed before or after the consolidation. In order to obtain the larger pores in the surface layer a laser process and/or an ultrasound process or a water jet cutting process are par¬ ticularly useful. In this way pores having a particularly favorable pore profile can be obtained, which reduces the tension concentrations around the pores. When using such a technique, which means that not only a pore size and a pore depth are chosen but also a pore profile, the implant material can be stressed more than before, the Y-value in
1/2 the rupture mechanical basis formula K = Y σc being lowered from L* the theoretical maximum value of 1.98 to about 1.2-1.4.
As regards materials, obtained by consolidating powders of various metals or very resistant ceramic materials, combinations of a fine porosity and a coarse (macro-) porosity can be obtained through some sintering process, which is not completed and is followed by a surface treatment, e.g. through some of the techniques described above, in order to obtain a macrosurface porosity. Interesting materials are
Co-Cr-steels, Ti-alloys and cerams, primarily oxides of aluminum and zirconium as well as non-oxidic materials of silicon nitride- and SiAlON-type.
Additional characterizing features and aspects of the present inven¬ tion are set forth in the following examples and the enclosed patent claims.
BRIEF DESCRIPTION OF DRAWINGS In the following description reference will be made to the accom¬ panying drawings, in which:
Fig. 1 shows a shoulder prosthesis with a portion consisting of a porous material according to the invention; Fig. 2 shows a hip joint prosthesis, in which also a portion consists of a porous material according to the invention;
Fig. 3 shows a dental implant, designed to fasten teeth in a bone,
which implant also has a porous portion according to the invention; Fig. 4-7 schematicly show how surface macropores present in the material may be designed; and
Fig. 8 is a diagram, which shows the transverse force required to discharge an implant as a function of the ingrowth time.
DESCRIPTION OF EMBODIMENTS
Example 1
Fibers consisting of pieces, 1-2 mm, of a nylon cord having a diameter of 0.2 mm are added to a powder mixture comprising zirconium oxide and 3 percent by volume yttrium oxide. The amount of fibers is 12 percent by volume. The mixture is rumbled for 2 hours in a roller-type ball mill with a polymer container and spherical crushing balls made of zirconium oxide. Raw compacts are made through cold pressing at a pressure of 250 MPa. The raw compacts are heat treated in order to evaporate the organic component, i.e. the nylon fibers. The evapora¬ tion is done by elevating the temperature 5°C/hour up to 500°C. The relatively brittle raw compact which is obtained is sintered at 1550°C for 3 h. Hg-porosimetry shows pores with a size of about 1 μm. An optical examination in a light microscope of a cross-section shows a presence of large pores with a size of about 170 μm.
Example 2
An aluminum oxide powder of a grade called AKP 30, having a "specific surface (BET) of about 20 m2/g, which corresponds to a grain size of less than 0.1 μm, is compressed to a cubic specimen with the dimen¬ sions 10 x 10 x 10 mm. The specimen, encased in glass, is densified by means of a hot isostatic pressing, a so called HIP-ing. The densifica- tion (compression) is done at 1150°C for 20 min. The maximum pressure at the highest temperature is 160 MPa. The porosity is measured through a water penetration and is 14.5 percent by volume. Hg- porosimetry shows that the main part, i.e. >90 % of the pores is within the interval of 0.4-0.7 μm with a mean pore size of 0.6 μm, whereas <3 % of the total pore volume is within the interval 10-50 μm.
Example 3
To a silicon raw material comprising a silicon powder called Sicomill 4D methyl alcohol is added. Subsequent to a careful rumbling grains larger than 5 μm are separated through a sedimentation. Thus, the remaining silicon raw material comprises powders with grain sizes <5 μm. A raw compact with the dimensions 10 x 5 x 30 mm is made through a cold isostatic pressing with 3 percent by volume poly¬ ethylene glycol as a lubricant. The evaporation of PEG is done through a heating with about 10°C/hour up to 400°C. Subsequently the raw compact is nitridized with a nitrogen gas containing atomosphere in two steps at 1160°C for 5 h and at 1400°C for 15 h, a reaction bound silicon nitride, Si K (RBSN) being obtained. The nitridized specimen has a 22 percent by volume open (communicating) porosity, measured through a vacuum suction and a water penetration. Hg-porosimetry shows a very narrow pore size distribution with >90 % of the total pore volume in the interval of 0.2-1.0 μm and with <3 % in the interval of 10-50 μm. As to the pores in the interval of 0.2-1.0 μm the main part is more exactly within the interval of 0.2-0.4 μm.
Example 4
10 percent by volume glass fibers, made of CaAl-silicates, cemented to a diameter of 150 μm and having a length of 1-2 mm are added to a silicon nitride raw material called UBE E10. The mixture is homoge¬ nized and raw compacts are made in the same way as in Example 1. Specimens are made through a sintering of the raw compacts at 1800°C for 2 h in a nitrogen gas atmosphere in a powder bed of coarse silicon nitride. The total porosity of the specimens is measured through a water penetration to 11 percent by volume. An optical examination in a light microscope shows a coarse fraction of pores having a size of about 150 μm.
Example 5
From plates, made of completely dense silicon nitride, containing 2 % yttrium oxide and having a density of 3.22 g/mm3 , made through a hot isostatic pressing at 1750°C, 160 MPa, 1 hour, 20 rod specimens are made, with the dimensions 3.5 x 4.5 x 40 mm, designed for a strength
testing, through a cutting and an edge breaking (45°). Half the amount of the rod specimens are provided with macropores on one side thereof through a computer controlled laser cutting, which gives a pore profile, which is shown εchematicly in Fig. 5. Strength measurements show that with pores having a depth of 200 μm and a profile according to Fig. 5 a lowering of the mean strength is obtained, determined through a 4-point bending test, from 680 MPa (without macropores) to
350 MPa. The mean value 350 indicates that the Y-value in the equation
1/2 ((11)) iiss llooww.. WWiitthh aa mmeeaassuurreedd rruuppttuurree ssttrrength value of 5.0 MPam this corresponds to an Y-value of about 1.2.
Example 6
Raw compacts from Example 3 are provided with surface macropores having a size of about 200 μm, obtained by treating the surface with a stamp having densely distributed outwardly projecting nails, called a "nail mat". The nails have a central distance of 400 μm and produce an impression with a depth of 200 μm. The profile of the impressions is shown in Fig. 7. Subsequently the specimens are nitridized in the same way as in Example 3.
The mean strength of the material, without surface macropores, which is made according to Example 3, determined through a 4-point bending test, is 290 MPa. A material with surface macropores, made according to Example 1, has a strength of 150 MPa, determined according to the same 4-point bending test.
Example 7
This example relates to a method of producing the material according to the invention. Specimens consisting of sintered zirconium oxide with 3 percent by volume yttrium oxide and having a density of 6.07 g/cm3 are surface treated with ultrasound, a boron carbide slurry/slamma with a grain size of about 30 μm being used. Ultrasound tools with varying topography, which corresponds to pore configura¬ tions according to Figs. 4 and 6, are used.
Example 8
This example shows a few feasible applications for the invention. A computer-controlled laser cutting can be used for the production of surface macropores on three implant components within areas, which when the implant is used are subjected to a low mechanical stress. The material within these areas consists of porous materials according to the invention and has been shaded in Figs. 1-3. These components are:
- a shoulder joint component, Fig. 1;
- a hip joint component (main, stem), Fig. 2; and
- a dental implant, Fig. 3.
The remaining parts of the implants, i.e. the non-shaded, more highly stressed portions, can consist of materials, which are more conven¬ tional implant materials, or also of other unconventional materials, which meet the specific requirements for these parts of the respective implant.
Example 9
Cylinders with a diameter of 2.8 mm and a length of 7 mm are produced from materials with surface macropores, described in Examples 3, 5, 6 and 7. These cylinders are inserted in a thigh bone in a rabbit. After three months the animals are killed and the necessary transverse forces for a discharge of the cylinders are determined with a so called push-out test. The results are compiled in Table 1:
Table 1
Material Transverse force (MPa) Remarks
RBSN (Example 3) 2 No surface macro pores
RBSN (Example 6) 11 With " " " Zirconium oxide
(Example 7, pore appearance
Fig. 4) 12 With
Silicon nitride (Example 5) 10 With
Silicon nitride (ref.-material) 2 No
Example 10
Cylinders with a diameter of 2.8 mm and a length of 7 mm, made of a material according to Example 2, i.e. consisting of a finely porous aluminum oxide, are surface treated through a laser process according to Example 5 in order to produce complex pore size distributions, namely a microporous fraction in the entire material, obtained when the cylinders are produced, and a acroporous surface fraction. The configuration of the surface macropores corresponds to what is shown in Fig. 5. In the open fine pore-structure Ca-phosphate is precipita- ted by reaction between calcium hydroxide and ammonium phosphate. In a similar way other bone growth stimulating agents can be added to the fine pore-structure, e.g. a bone growth factor or anti-inflammatory agents, e.g. through a freeze dehydration process. Cylinders, which are produced and treated in this way, are implanted in a thigh bone in rabbits. The animals are killed after 2, 5 and 8 weeks. Reference material without any Ca-phosphate deposit. The transverse forces between an implant and a new growth of bone is determined by a push- out testing. The results are shown in Fig. 8, which shows the trans¬ verse force as a function of the ingrowth time (weeks).
Claims
1. An implant made of a porous, non-toxic material with a total open porosity larger than 5 percent by volume but not larger than 80 per¬ cent by volume within at least a portion of the implant, c h a - r a c t e r i z e d in that:
- communicating pores with a pore size within the interval of 0.1-10 μm occupy 10-80 percent of the total pore volume in said at least one portion of the implant;
- pores with a pore size within the interval of 10-50 μm occupy not more than 5 % of the total pore volume in said at least one portion of the implant; and
- 5-40 % of at least one portion of the surface of the implant is covered by mainly evenly distributed pores having a pore size within the interval of 50-500 μm.
2. An implant according to claim 1, c h a r a c t e r i z e d in that said communicating pores with a pore size within the interval of 0.1-10 μm occupy 25-75 %, suitably 40-60 %, of the total pore volume in said at least one portion of the implant material.
3. An implant according to claims 1 or 2, c h a r a c t e r i z e d in that said communicating pores have a pore size within the interval of 0.3-8 μm, suitably within the interval of 0.5-5 μm.
4. An implant according to claim 1, c h a r a c t e r i z e d in that 10-30 %, suitably 15-25 % of the surface within said at least one portion of the implant is covered by the pores having a pore size within the interval of 50-500 μm, which pores mainly are evenly distributed over the surface of said portion.
5. An implant according to claims 1 or 4, c h a r a c t e r i z e d in that the main part of the large pores in the surface layer have a size within the range of 75-400 μm, preferably within the range of 100-300 μm and suitably within the interval of 150-250 μm.
6. An implant according to any of claims 1, 4 and 5, c h a r a c t e ¬ r i z e d in that the large pores only are present in a surface layer, which has a thickness of 3 mm, preferably 2 mm and suitably 0.3 mm.
7. An implant according to any of claims 1-6, c h a r a c t e ¬ r i z e d in that 10-80 % of the total pore volume is occupied by the larger pores having a pore size within the interval of 50-500 μm.
8. An implant according to any of claims 1-7, c h a r a c t e ¬ r i z e d in that said at least one portion of the implant mainly consists of a reaction bound silicon nitride.
9. An implant according to any of claims 1-7, c h a r a c t e - r i z e d in that said at least one portion of the implant mainly consists of one or several of calcium phosphate materials, titanium, SiC, Cr0p, chromium, cobalt-steels, high-alloyed stainless steels and polymers.
10. An implant according to any of claims 1-9, c h a r a c t e ¬ r i z e d in that said communicating pores with the smaller pore size contain deposited substances, having desirable medical and/or biolo¬ gical functions.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU39637/93A AU3963793A (en) | 1991-06-03 | 1993-03-11 | A process for recovering chemicals and energy from cellulose waste liquor |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9101677A SE468502B (en) | 1991-06-03 | 1991-06-03 | POROEST IMPLANT |
SE9101677-4 | 1991-06-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1992021302A1 true WO1992021302A1 (en) | 1992-12-10 |
Family
ID=20382915
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/SE1992/000366 WO1992021302A1 (en) | 1991-06-03 | 1992-05-29 | An implant |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU1908192A (en) |
SE (1) | SE468502B (en) |
WO (1) | WO1992021302A1 (en) |
Cited By (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993013815A1 (en) * | 1992-01-13 | 1993-07-22 | Lucocer Aktiebolag | An implant |
WO1995009583A1 (en) * | 1993-10-01 | 1995-04-13 | Lucocer Aktiebolag | An implant |
WO1996019248A2 (en) * | 1994-12-21 | 1996-06-27 | Board Of Regents, The University Of Texas System | METHOD OF CONTROLLING pH IN THE VICINITY OF BIODEGRADABLE IMPLANTS, AND METHOD OF INCREASING SURFACE POROSITY |
EP0746273A1 (en) * | 1993-11-02 | 1996-12-11 | Hospital For Joint Diseases | Control of cell growth |
EP0761182A2 (en) * | 1995-08-29 | 1997-03-12 | JOHNSON & JOHNSON PROFESSIONAL Inc. | Bone prosthesis with protected coating for penetrating bone intergrowth |
DE19545470A1 (en) * | 1995-12-06 | 1997-07-31 | Matthias Dr Med Honl | End prosthesis or implant surface |
US5658334A (en) * | 1994-02-18 | 1997-08-19 | Johnson & Johnson Professional, Inc. | Implantable articles with as-cast macrotextured surface regions and method of manufacturing same |
US5665118A (en) * | 1994-02-18 | 1997-09-09 | Johnson & Johnson Professional, Inc. | Bone prostheses with direct cast macrotextured surface regions and method for manufacturing the same |
WO1997046179A1 (en) * | 1996-06-03 | 1997-12-11 | Mathys Medizinaltechnik Ag | Femur component for a hip endoprosthesis |
WO1998016267A1 (en) * | 1996-10-15 | 1998-04-23 | University College Dublin | Bone replacement materials with interconnecting pore system |
EP0891754A2 (en) * | 1997-07-18 | 1999-01-20 | Implantech Medizintechnik Ges.m.b.H. | Implant, especially joint prosthesis implant |
EP0827726A3 (en) * | 1996-09-04 | 1999-03-03 | Implantech Medizintechnik Ges.m.b.H. | Implant, especially prosthetic joint implant |
EP1159935A1 (en) * | 2000-05-31 | 2001-12-05 | SAY, Wen-Ching | Orthopedic implant having a porous surface and method of making same |
DE10060036C1 (en) * | 2000-12-02 | 2002-08-08 | Dot Gmbh | Inorganic resorbable bone substitute material |
FR2827155A1 (en) * | 2001-07-16 | 2003-01-17 | Biomet Merck France | Hip prosthesis femoral shank has pairs of cavities in inner face of metaphysis section |
WO2003013396A1 (en) * | 2001-08-11 | 2003-02-20 | Stanmore Implants Worldwide Ltd. | Surgical implant |
WO2003047471A1 (en) * | 2001-11-30 | 2003-06-12 | Depuy International Limited | Femoral component of hip joint prosthesis |
EP1358859A1 (en) * | 2002-04-29 | 2003-11-05 | Politecnico Di Milano | Bone prostheses having multilayer interface |
DE10328892A1 (en) * | 2003-06-26 | 2005-05-12 | Curasan Ag | Bone building agent and manufacturing process |
NL1030364C2 (en) * | 2005-11-07 | 2007-05-08 | Ft Innovations Fti B V | Implant and method for manufacturing such an implant. |
US8524265B2 (en) * | 2006-08-17 | 2013-09-03 | Warsaw Orthopedic, Inc. | Medical implant sheets useful for tissue regeneration |
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1991
- 1991-06-03 SE SE9101677A patent/SE468502B/en not_active IP Right Cessation
-
1992
- 1992-05-29 AU AU19081/92A patent/AU1908192A/en not_active Abandoned
- 1992-05-29 WO PCT/SE1992/000366 patent/WO1992021302A1/en active Application Filing
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Cited By (36)
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US5464440A (en) * | 1992-01-13 | 1995-11-07 | Lucocer Aktiebolag | Porous implant with two sets of pores |
WO1993013815A1 (en) * | 1992-01-13 | 1993-07-22 | Lucocer Aktiebolag | An implant |
WO1995009583A1 (en) * | 1993-10-01 | 1995-04-13 | Lucocer Aktiebolag | An implant |
EP0746273A1 (en) * | 1993-11-02 | 1996-12-11 | Hospital For Joint Diseases | Control of cell growth |
EP0746273A4 (en) * | 1993-11-02 | 1998-11-25 | Hospital For Joint Diseases | Control of cell growth |
US5713410A (en) * | 1994-02-18 | 1998-02-03 | Johnson & Johnson Professional, Inc. | Bone prostheses with direct cast macrotextured surface regions and method for manufacturing the same |
US5658334A (en) * | 1994-02-18 | 1997-08-19 | Johnson & Johnson Professional, Inc. | Implantable articles with as-cast macrotextured surface regions and method of manufacturing same |
US5665118A (en) * | 1994-02-18 | 1997-09-09 | Johnson & Johnson Professional, Inc. | Bone prostheses with direct cast macrotextured surface regions and method for manufacturing the same |
US5687788A (en) * | 1994-02-18 | 1997-11-18 | Johnson & Johnson Professional, Inc. | Implantable articles with as-cast macrotextured surface regions and method of manufacturing the same |
WO1996019248A3 (en) * | 1994-12-21 | 1996-11-14 | Univ Texas | METHOD OF CONTROLLING pH IN THE VICINITY OF BIODEGRADABLE IMPLANTS, AND METHOD OF INCREASING SURFACE POROSITY |
WO1996019248A2 (en) * | 1994-12-21 | 1996-06-27 | Board Of Regents, The University Of Texas System | METHOD OF CONTROLLING pH IN THE VICINITY OF BIODEGRADABLE IMPLANTS, AND METHOD OF INCREASING SURFACE POROSITY |
EP0761182A2 (en) * | 1995-08-29 | 1997-03-12 | JOHNSON & JOHNSON PROFESSIONAL Inc. | Bone prosthesis with protected coating for penetrating bone intergrowth |
EP0761182A3 (en) * | 1995-08-29 | 1998-03-18 | JOHNSON & JOHNSON PROFESSIONAL Inc. | Bone prosthesis with protected coating for penetrating bone intergrowth |
US6008431A (en) * | 1995-08-29 | 1999-12-28 | Johnson & Johnson Professional, Inc. | Bone prosthesis with protected coating for penetrating bone intergrowth |
DE19545470A1 (en) * | 1995-12-06 | 1997-07-31 | Matthias Dr Med Honl | End prosthesis or implant surface |
WO1997046179A1 (en) * | 1996-06-03 | 1997-12-11 | Mathys Medizinaltechnik Ag | Femur component for a hip endoprosthesis |
EP0827726A3 (en) * | 1996-09-04 | 1999-03-03 | Implantech Medizintechnik Ges.m.b.H. | Implant, especially prosthetic joint implant |
WO1998016267A1 (en) * | 1996-10-15 | 1998-04-23 | University College Dublin | Bone replacement materials with interconnecting pore system |
EP0891754A2 (en) * | 1997-07-18 | 1999-01-20 | Implantech Medizintechnik Ges.m.b.H. | Implant, especially joint prosthesis implant |
EP0891754A3 (en) * | 1997-07-18 | 1999-03-03 | Implantech Medizintechnik Ges.m.b.H. | Implant, especially joint prosthesis implant |
EP1159935A1 (en) * | 2000-05-31 | 2001-12-05 | SAY, Wen-Ching | Orthopedic implant having a porous surface and method of making same |
DE10060036C1 (en) * | 2000-12-02 | 2002-08-08 | Dot Gmbh | Inorganic resorbable bone substitute material |
FR2827155A1 (en) * | 2001-07-16 | 2003-01-17 | Biomet Merck France | Hip prosthesis femoral shank has pairs of cavities in inner face of metaphysis section |
AU2002321451B2 (en) * | 2001-08-11 | 2007-03-01 | Stanmore Implants Worldwide Ltd. | Surgical implant |
WO2003013396A1 (en) * | 2001-08-11 | 2003-02-20 | Stanmore Implants Worldwide Ltd. | Surgical implant |
KR100889650B1 (en) * | 2001-08-11 | 2009-03-19 | 스탠모어 임플란츠 월드와이드 리미티드 | Surgical implant |
US7241313B2 (en) * | 2001-08-11 | 2007-07-10 | Stanmore Implants Worldwide Limited | Surgical implant |
WO2003047471A1 (en) * | 2001-11-30 | 2003-06-12 | Depuy International Limited | Femoral component of hip joint prosthesis |
EP1358859A1 (en) * | 2002-04-29 | 2003-11-05 | Politecnico Di Milano | Bone prostheses having multilayer interface |
WO2003092555A1 (en) * | 2002-04-29 | 2003-11-13 | Franco Maria Montevecchi | Bone prosthesis with multilayer interface |
DE10328892A1 (en) * | 2003-06-26 | 2005-05-12 | Curasan Ag | Bone building agent and manufacturing process |
US8778374B2 (en) | 2003-06-26 | 2014-07-15 | Curasan Ag | Bone formation agent and method of production |
NL1030364C2 (en) * | 2005-11-07 | 2007-05-08 | Ft Innovations Fti B V | Implant and method for manufacturing such an implant. |
WO2007053022A2 (en) * | 2005-11-07 | 2007-05-10 | Ft Innovations (Fti) B.V. | Implant and method for manufacturing such an implant |
WO2007053022A3 (en) * | 2005-11-07 | 2007-08-16 | Ft Innovations Fti B V | Implant and method for manufacturing such an implant |
US8524265B2 (en) * | 2006-08-17 | 2013-09-03 | Warsaw Orthopedic, Inc. | Medical implant sheets useful for tissue regeneration |
Also Published As
Publication number | Publication date |
---|---|
SE9101677D0 (en) | 1991-06-03 |
SE9101677L (en) | 1992-12-04 |
AU1908192A (en) | 1993-01-08 |
SE468502B (en) | 1993-02-01 |
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