WO1993005162A1 - Method for delivering nucleic acids into cells - Google Patents
Method for delivering nucleic acids into cells Download PDFInfo
- Publication number
- WO1993005162A1 WO1993005162A1 PCT/US1992/007290 US9207290W WO9305162A1 WO 1993005162 A1 WO1993005162 A1 WO 1993005162A1 US 9207290 W US9207290 W US 9207290W WO 9305162 A1 WO9305162 A1 WO 9305162A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- group
- cholesteryl
- lipid
- cationic
- cholesterol
- Prior art date
Links
- 0 CC(C)CCCC(C)C(CC1)C(CC2)C1C1C2C(C)(CCC(*)C2)C2=CC1 Chemical compound CC(C)CCCC(C)C(CC1)C(CC2)C1C1C2C(C)(CCC(*)C2)C2=CC1 0.000 description 1
- PHYKSCBUCCTIBN-UHFFFAOYSA-N CCC(CC1)CC(CC2)C1(C)C2C(C)CCCC(C)C Chemical compound CCC(CC1)CC(CC2)C1(C)C2C(C)CCCC(C)C PHYKSCBUCCTIBN-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Dispersion Chemistry (AREA)
- Cell Biology (AREA)
- Botany (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT92920321T ATE292690T1 (en) | 1991-08-28 | 1992-08-28 | METHOD FOR TRANSFER OF NUCLEIC ACIDS INTO CELLS |
JP50530293A JP3258661B2 (en) | 1991-08-28 | 1992-08-28 | Method for transferring nucleic acid into cells |
DK92920321T DK0663013T3 (en) | 1991-08-28 | 1992-08-28 | Method of delivering nucleic acids to cells |
DE69233497T DE69233497T2 (en) | 1991-08-28 | 1992-08-28 | METHOD OF TRANSFERRING NUCLEIC ACIDS IN CELLS |
EP92920321A EP0663013B1 (en) | 1991-08-28 | 1992-08-28 | Method for delivering nucleic acids into cells |
AU26565/92A AU665029B2 (en) | 1991-08-28 | 1992-08-28 | Method for delivering nucleic acids into cells |
HK98116092A HK1014736A1 (en) | 1991-08-28 | 1999-03-11 | Method for delivering nucleic acids into cells. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US751,873 | 1991-08-28 | ||
US07/751,873 US5283185A (en) | 1991-08-28 | 1991-08-28 | Method for delivering nucleic acids into cells |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1993005162A1 true WO1993005162A1 (en) | 1993-03-18 |
Family
ID=25023883
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1992/007290 WO1993005162A1 (en) | 1991-08-28 | 1992-08-28 | Method for delivering nucleic acids into cells |
Country Status (12)
Country | Link |
---|---|
US (1) | US5283185A (en) |
EP (1) | EP0663013B1 (en) |
JP (2) | JP3258661B2 (en) |
AT (1) | ATE292690T1 (en) |
AU (1) | AU665029B2 (en) |
CA (1) | CA2116676A1 (en) |
DE (1) | DE69233497T2 (en) |
DK (1) | DK0663013T3 (en) |
ES (1) | ES2240958T3 (en) |
HK (1) | HK1014736A1 (en) |
SG (1) | SG50630A1 (en) |
WO (1) | WO1993005162A1 (en) |
Cited By (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993019768A1 (en) * | 1992-04-03 | 1993-10-14 | The Regents Of The University Of California | Self-assembling polynucleotide delivery system |
WO1995027478A1 (en) * | 1994-04-12 | 1995-10-19 | The Liposome Company, Inc. | Fusogenic liposomes and methods of making and using same |
FR2722506A1 (en) * | 1994-07-13 | 1996-01-19 | Rhone Poulenc Rorer Sa | COMPOSITION CONTAINING NUCLEIC ACIDS, PREPARATION AND USES |
WO1996001841A1 (en) * | 1994-07-08 | 1996-01-25 | Gilead Sciences, Inc. | Cationic lipids for delivery of nucleic acids to cells |
FR2726764A1 (en) * | 1994-11-14 | 1996-05-15 | Pasteur Merieux Serums Vacc | ADDITIVE FOR VACCINE COMPOSITION |
WO1996037194A1 (en) * | 1995-05-26 | 1996-11-28 | Somatix Therapy Corporation | Delivery vehicles comprising stable lipid/nucleic acid complexes |
WO1997011682A2 (en) * | 1995-09-26 | 1997-04-03 | University Of Pittsburgh | Emulsion and micellar formulations for the delivery of biologically active substances to cells |
EP0773719A1 (en) * | 1994-07-29 | 1997-05-21 | Emory University | Compositions for targeting materials to cells containing androgen receptors |
WO1997025339A1 (en) * | 1996-01-05 | 1997-07-17 | Commonwealth Scientific And Industrial Research Organisation | Composition and method for delivery of nucleic acids |
FR2744453A1 (en) * | 1996-02-05 | 1997-08-08 | Transgene Sa | LIPOPOLYAMINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING NUCLEIC ACID TRANSFER VECTORS AND PROCESS FOR PREPARING THE SAME |
WO1997031935A1 (en) * | 1996-03-01 | 1997-09-04 | Centre National De La Recherche Scientifique | Compounds related to the amidinium family, pharmaceutical compositions containing same, and uses thereof |
FR2745569A1 (en) * | 1996-03-01 | 1997-09-05 | Centre Nat Rech Scient | New amidinium-substituted carbamate derivatives of cholesterol or alkanolamine |
WO1997039019A1 (en) * | 1996-04-12 | 1997-10-23 | University Of Pittsburgh | Novel cationic cholesteryl derivatives containing cyclic polar groups |
WO1997045442A1 (en) * | 1996-05-24 | 1997-12-04 | Imperial College Of Science Technology And Medicine | Polycationic sterol derivatives as transfection agents |
US5705385A (en) * | 1995-06-07 | 1998-01-06 | Inex Pharmaceuticals Corporation | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
WO1998000110A1 (en) * | 1996-07-03 | 1998-01-08 | University Of Pittsburgh | Emulsion formulations for hydrophilic active agents |
WO1998002191A2 (en) * | 1996-07-15 | 1998-01-22 | Genzyme Corporation | Cationic amphiphile compositions for intracellular delivery of therapeutic molecules |
WO1998002190A2 (en) * | 1996-07-12 | 1998-01-22 | Genzyme Corporation | Cationic amphiphile/dna complexes |
FR2751972A1 (en) * | 1996-07-30 | 1998-02-06 | Centre Nat Rech Scient | New amidinium-substituted carbamate derivatives of cholesterol or alkanolamine |
WO1998008489A1 (en) * | 1996-08-26 | 1998-03-05 | Transgene S.A. | Cationic lipid-nucleic acid complexes |
WO1998017689A2 (en) * | 1996-10-18 | 1998-04-30 | Valentis Inc. | Il-12 gene expression and delivery systems and uses |
WO1998017814A2 (en) * | 1996-10-18 | 1998-04-30 | Valentis Inc. | Gene expression and delivery systems and uses |
WO1998019709A2 (en) * | 1996-11-04 | 1998-05-14 | Qiagen Gmbh | Cationic reagents for transfection |
US5753613A (en) * | 1994-09-30 | 1998-05-19 | Inex Pharmaceuticals Corporation | Compositions for the introduction of polyanionic materials into cells |
US5753262A (en) * | 1995-06-07 | 1998-05-19 | Aronex Pharmaceuticals, Inc. | Cationic lipid acid salt of 3beta N- (N', N'-dimethylaminoethane) - carbamoyl!cholestrol and halogenated solvent-free preliposomal lyophilate thereof |
US5785992A (en) * | 1994-09-30 | 1998-07-28 | Inex Pharmaceuticals Corp. | Compositions for the introduction of polyanionic materials into cells |
WO1998048836A1 (en) * | 1997-04-30 | 1998-11-05 | Merieux Oravax | Anti-helicobacter vaccine composition comprising a th1 adjuvant |
FR2762788A1 (en) * | 1997-04-30 | 1998-11-06 | Pasteur Merieux Serums Vacc | Use of immunogenic agent derived from Helicobacter |
FR2762787A1 (en) * | 1997-04-30 | 1998-11-06 | Pasteur Merieux Serums Vacc | Helicobacter-derived immunogen for use as vaccine |
EP0890577A1 (en) * | 1997-07-10 | 1999-01-13 | L'oreal | Composition comprising an aqueous dispersion of lipid vesicules, based on cholesteryl carbamates, cosmetic use and compounds |
WO1999012945A2 (en) * | 1997-09-08 | 1999-03-18 | Valentis,Inc. | Hydrophobic glycosylamine derivatives, compositions, and methods for use |
US5908635A (en) * | 1994-08-05 | 1999-06-01 | The United States Of America As Represented By The Department Of Health And Human Services | Method for the liposomal delivery of nucleic acids |
US5928944A (en) * | 1994-02-04 | 1999-07-27 | The United States Of America As Represented By The Department Of Health And Human Services | Method of adenoviral-medicated cell transfection |
WO1999038821A2 (en) * | 1998-01-30 | 1999-08-05 | Aventis Pharma S.A. | Transfecting compositions sensitive to reducing conditions, pharmaceutical compositions containing them, and their applications |
FR2774394A1 (en) * | 1998-01-30 | 1999-08-06 | Rhone Poulenc Rorer Sa | Agent for transfer of nucleic acid containing cationic hydrophilic and lipophilic regions, e.g. for gene therapy |
FR2777017A1 (en) * | 1998-04-02 | 1999-10-08 | Rhone Poulenc Rorer Sa | Nucleic acid transfer agent useful for transfecting cells, especially muscle cells in vivo |
WO1999051581A1 (en) * | 1998-04-02 | 1999-10-14 | Aventis Pharma S.A. | Novel nucleic acid transfer agents, compositions containing same and uses |
US5976567A (en) * | 1995-06-07 | 1999-11-02 | Inex Pharmaceuticals Corp. | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
US5981501A (en) * | 1995-06-07 | 1999-11-09 | Inex Pharmaceuticals Corp. | Methods for encapsulating plasmids in lipid bilayers |
US6075012A (en) * | 1994-02-11 | 2000-06-13 | Life Technologies, Inc. | Reagents for intracellular delivery of macromolecules |
US6093816A (en) * | 1996-06-27 | 2000-07-25 | Isis Pharmaceuticals, Inc. | Cationic lipids |
WO2000073471A1 (en) * | 1999-05-28 | 2000-12-07 | Jong Sang Park | Cationic lipids for gene transfer and preparation method thereof |
FR2797188A1 (en) * | 1999-08-04 | 2001-02-09 | Univ Paris Nord Laboratoire De | CATIONIC LIPID COMPOUNDS AND THEIR USE FOR THE TRANSFER OF NEGATIVELY CHARGED SUBSTANCES OF THERAPEUTIC INTEREST |
US6258792B1 (en) | 1996-04-12 | 2001-07-10 | University Of Pittsburgh | Cationic cholesteryl derivatives containing cyclic polar groups |
WO2001057064A2 (en) * | 2000-02-07 | 2001-08-09 | Roche Diagnostics Corporation | Cationic amphiphiles for use in nucleic acid transfection |
US6331524B1 (en) | 1994-12-09 | 2001-12-18 | Genzyme Corporation | Organ-specific targeting of cationic amphiphile / DNA complexes for gene therapy |
US6376248B1 (en) | 1997-03-14 | 2002-04-23 | Life Technologies, Inc. | Peptide-enhanced transfections |
US6383814B1 (en) | 1994-12-09 | 2002-05-07 | Genzyme Corporation | Cationic amphiphiles for intracellular delivery of therapeutic molecules |
US6586410B1 (en) | 1995-06-07 | 2003-07-01 | Inex Pharmaceuticals Corporation | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
US6989434B1 (en) | 1994-02-11 | 2006-01-24 | Invitrogen Corporation | Reagents for intracellular delivery of macromolecules |
US7312206B2 (en) | 2001-02-21 | 2007-12-25 | Novosom Ag | Sterol derivatives, liposomes comprising sterol derivatives and method for loading liposomes with active substances |
US7550452B2 (en) | 2000-09-21 | 2009-06-23 | Goodgene, Inc. | Cationic lipids and use thereof |
US7745651B2 (en) | 2004-06-07 | 2010-06-29 | Protiva Biotherapeutics, Inc. | Cationic lipids and methods of use |
US7799565B2 (en) | 2004-06-07 | 2010-09-21 | Protiva Biotherapeutics, Inc. | Lipid encapsulated interfering RNA |
US7803397B2 (en) | 2003-09-15 | 2010-09-28 | Protiva Biotherapeutics, Inc. | Polyethyleneglycol-modified lipid compounds and uses thereof |
US7807815B2 (en) | 2004-07-02 | 2010-10-05 | Protiva Biotherapeutics, Inc. | Compositions comprising immunostimulatory siRNA molecules and DLinDMA or DLenDMA |
US7915399B2 (en) | 2006-06-09 | 2011-03-29 | Protiva Biotherapeutics, Inc. | Modified siRNA molecules and uses thereof |
US7982027B2 (en) | 2003-07-16 | 2011-07-19 | Protiva Biotherapeutics, Inc. | Lipid encapsulated interfering RNA |
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US8058069B2 (en) | 2008-04-15 | 2011-11-15 | Protiva Biotherapeutics, Inc. | Lipid formulations for nucleic acid delivery |
US8101741B2 (en) | 2005-11-02 | 2012-01-24 | Protiva Biotherapeutics, Inc. | Modified siRNA molecules and uses thereof |
US8283333B2 (en) | 2009-07-01 | 2012-10-09 | Protiva Biotherapeutics, Inc. | Lipid formulations for nucleic acid delivery |
US8496961B2 (en) | 2002-05-15 | 2013-07-30 | Sutter West Bay Hospital | Delivery of nucleic acid-like compounds |
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WO2014153258A2 (en) | 2013-03-14 | 2014-09-25 | Epeius Biotechnologies Corporation | Improved thymidine kinase gene |
US9006417B2 (en) | 2010-06-30 | 2015-04-14 | Protiva Biotherapeutics, Inc. | Non-liposomal systems for nucleic acid delivery |
US9017659B2 (en) | 2006-11-03 | 2015-04-28 | Epeius Biotechnologies Corporation | Pathotropic targeted gene delivery system for cancer and other disorders |
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US11591544B2 (en) | 2020-11-25 | 2023-02-28 | Akagera Medicines, Inc. | Ionizable cationic lipids |
Families Citing this family (368)
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---|---|---|---|---|
US6509032B1 (en) * | 1991-08-28 | 2003-01-21 | Mcmaster University | Cationic amphiphiles |
US5795870A (en) * | 1991-12-13 | 1998-08-18 | Trustees Of Princeton University | Compositions and methods for cell transformation |
US5693769A (en) * | 1991-12-13 | 1997-12-02 | Transcell Technologies, Inc. | Glycosylated steroid derivatives for transport across biological membranes and process for making and using same |
IL101241A (en) * | 1992-03-16 | 1997-11-20 | Yissum Res Dev Co | Pharmaceutical or cosmetic composition comprising stabilized oil-in-water type emulsion as carrier |
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US5866135A (en) * | 1994-04-21 | 1999-02-02 | North American Vaccine, Inc. | Group A streptococcal polysaccharide immunogenic compositions and methods |
US5837533A (en) * | 1994-09-28 | 1998-11-17 | American Home Products Corporation | Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent |
US5719131A (en) * | 1994-12-09 | 1998-02-17 | Genzyme Corporation | Cationic amphiphiles containing dialkylamine lipophilic groups for intracellular delivery of therapeutic molecules |
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US6071890A (en) * | 1994-12-09 | 2000-06-06 | Genzyme Corporation | Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy |
US5910487A (en) * | 1994-12-09 | 1999-06-08 | Genzyme Corporation | Cationic amphiphiles and plasmids for intracellular delivery of therapeutic molecules |
US5767099A (en) * | 1994-12-09 | 1998-06-16 | Genzyme Corporation | Cationic amphiphiles containing amino acid or dervatized amino acid groups for intracellular delivery of therapeutic molecules |
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US5840710A (en) * | 1994-12-09 | 1998-11-24 | Genzyme Corporation | Cationic amphiphiles containing ester or ether-linked lipophilic groups for intracellular delivery of therapeutic molecules |
US5786214A (en) * | 1994-12-15 | 1998-07-28 | Spinal Cord Society | pH-sensitive immunoliposomes and method of gene delivery to the mammalian central nervous system |
WO1996020208A2 (en) * | 1994-12-28 | 1996-07-04 | Max-Delbrück-Centrum für Molekulare Medizin | New cholesterol derivative for liposomal gene transfer |
US6008202A (en) | 1995-01-23 | 1999-12-28 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
US5795587A (en) * | 1995-01-23 | 1998-08-18 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
US5830430A (en) | 1995-02-21 | 1998-11-03 | Imarx Pharmaceutical Corp. | Cationic lipids and the use thereof |
US20030148968A1 (en) * | 1995-02-28 | 2003-08-07 | Hammond H. Kirk | Techniques and compositions for treating cardiovascular disease by in vivo gene delivery |
WO1996026742A1 (en) | 1995-02-28 | 1996-09-06 | The Regents Of The University Of California | Gene transfer-mediated angiogenesis therapy |
US6752987B1 (en) | 1995-02-28 | 2004-06-22 | The Regents Of The University Of California | Adenovirus encoding human adenylylcyclase (AC) VI |
US5658588A (en) * | 1995-03-31 | 1997-08-19 | University Of Cincinnati | Fibrinogen-coated liposomes |
FR2732895B1 (en) * | 1995-04-11 | 1997-05-16 | Pasteur Merieux Serums Vacc | USE OF A CATIONIC AMPHIPATHIC COMPOUND AS A TRANSFECTING AGENT, AS A VACCINE ADDITIVE, OR AS A MEDICINAL PRODUCT |
US5859228A (en) * | 1995-05-04 | 1999-01-12 | Nexstar Pharmaceuticals, Inc. | Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes |
US20030069173A1 (en) * | 1998-03-16 | 2003-04-10 | Life Technologies, Inc. | Peptide-enhanced transfections |
EP0840744A4 (en) * | 1995-06-07 | 1999-03-10 | Genta Inc | Phosphonic acid-based cationic lipids |
JPH11507352A (en) * | 1995-06-07 | 1999-06-29 | ジンタ・インコーポレイテッド | New carbamate-based cationic lipids |
US7002027B1 (en) | 1996-01-08 | 2006-02-21 | Canji, Inc. | Compositions and methods for therapeutic use |
US20050025742A1 (en) * | 1996-01-08 | 2005-02-03 | Canji, Inc. | Methods and compositions for interferon therapy |
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Also Published As
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EP0663013B1 (en) | 2005-04-06 |
EP0663013A4 (en) | 1994-11-28 |
SG50630A1 (en) | 1998-07-20 |
JP3258661B2 (en) | 2002-02-18 |
JPH07500963A (en) | 1995-02-02 |
ATE292690T1 (en) | 2005-04-15 |
ES2240958T3 (en) | 2005-10-16 |
DK0663013T3 (en) | 2005-08-01 |
CA2116676A1 (en) | 1993-03-18 |
AU2656592A (en) | 1993-04-05 |
HK1014736A1 (en) | 1999-09-30 |
EP0663013A1 (en) | 1995-07-19 |
JP2002153270A (en) | 2002-05-28 |
AU665029B2 (en) | 1995-12-14 |
DE69233497D1 (en) | 2005-05-12 |
DE69233497T2 (en) | 2006-01-26 |
US5283185A (en) | 1994-02-01 |
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