WO1993009176A3 - Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release - Google Patents

Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release Download PDF

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Publication number
WO1993009176A3
WO1993009176A3 PCT/US1992/009364 US9209364W WO9309176A3 WO 1993009176 A3 WO1993009176 A3 WO 1993009176A3 US 9209364 W US9209364 W US 9209364W WO 9309176 A3 WO9309176 A3 WO 9309176A3
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WO
WIPO (PCT)
Prior art keywords
polymerizable
materials
polycations
encapsulation
alginate
Prior art date
Application number
PCT/US1992/009364
Other languages
French (fr)
Other versions
WO1993009176A2 (en
Inventor
Patrick Soon-Shiong
Neil P Desai
Paul A Sandford
Roswitha A Heintz
Soebianto Sojomihardjo
Original Assignee
Clover Cons Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clover Cons Ltd filed Critical Clover Cons Ltd
Priority to JP5508638A priority Critical patent/JPH07503943A/en
Priority to EP92925046A priority patent/EP0610441A4/en
Priority to US08/232,054 priority patent/US5837747A/en
Publication of WO1993009176A2 publication Critical patent/WO1993009176A2/en
Publication of WO1993009176A3 publication Critical patent/WO1993009176A3/en

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive plasters or dressings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1273—Polymersomes; Liposomes with polymerisable or polymerised bilayer-forming substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0084—Guluromannuronans, e.g. alginic acid, i.e. D-mannuronic acid and D-guluronic acid units linked with alternating alpha- and beta-1,4-glycosidic bonds; Derivatives thereof, e.g. alginates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
    • C08F290/08—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated side groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
    • C08F290/08—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated side groups
    • C08F290/10—Polymers provided for in subclass C08B
    • A—HUMAN NECESSITIES
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    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00089—Wound bandages
    • A61F2013/00157—Wound bandages for burns or skin transplants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61F2013/00217—Wound bandages not adhering to the wound
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    • A61F2013/00621—Plasters form or structure cast
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    • A61F13/00—Bandages or dressings; Absorbent pads
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    • A61F2013/00727—Plasters means for wound humidity control
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    • A61F2013/00876—Plasters pervious to air or vapours vapour permeability >500 g/mg/24h
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    • A61F13/00—Bandages or dressings; Absorbent pads
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    • A61F2013/00902—Plasters containing means
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    • A61F13/00—Bandages or dressings; Absorbent pads
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    • A61F2013/00902—Plasters containing means
    • A61F2013/0091—Plasters containing means with disinfecting or anaesthetics means, e.g. anti-mycrobic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Abstract

The present invention relates to a new form of biocompatible materials (e.g., lipids, polycations, polysaccharides) which are capable of undergoing free radical polymerization, e.g., by using certain sources of light; methods of modifying certain synthetic and naturally occurring biocompatible materials to make polymerizable microcapsules containing biological material coated with said polymerizable materials, composites of said polymerizable materials, methods of making microcapsules and encapsulating biological materials therein, and apparatus for making microcapsules containing biological cells (particularly islets of Langerhans) coated with polymerizable alginate or with a composite thereof (e.g., alginate and PEG). The present invention also relates to drug delivery systems relating to the foregoing, as well as bioadhesives and wound dressings made utilizing the foregoing technology.
PCT/US1992/009364 1991-10-29 1992-10-29 Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release WO1993009176A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP5508638A JPH07503943A (en) 1991-10-29 1992-10-29 Cross-linked polysaccharides, polycations and lipids useful for encapsulation and drug release
EP92925046A EP0610441A4 (en) 1991-10-29 1992-10-29 Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release.
US08/232,054 US5837747A (en) 1991-10-29 1992-10-29 Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78426791A 1991-10-29 1991-10-29
US784,267 1991-10-29

Publications (2)

Publication Number Publication Date
WO1993009176A2 WO1993009176A2 (en) 1993-05-13
WO1993009176A3 true WO1993009176A3 (en) 1993-07-22

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PCT/US1992/009364 WO1993009176A2 (en) 1991-10-29 1992-10-29 Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release

Country Status (6)

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US (4) US5837747A (en)
EP (1) EP0610441A4 (en)
JP (1) JPH07503943A (en)
AU (1) AU3124793A (en)
CA (1) CA2121129A1 (en)
WO (1) WO1993009176A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8834451B2 (en) 2002-10-28 2014-09-16 Smith & Nephew Plc In-situ wound cleansing apparatus
US8858964B2 (en) 2010-04-15 2014-10-14 Marine Polymer Technologies, Inc. Anti-bacterial applications of poly-N-acetylglucosamine nanofibers
US8998866B2 (en) 2010-07-02 2015-04-07 Smith & Nephew Plc Provision of wound filler
US9139664B2 (en) 2007-02-19 2015-09-22 Marine Polymer Technologies, Inc. Hemostatic compositions and therapeutic regimens

Families Citing this family (230)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5380536A (en) * 1990-10-15 1995-01-10 The Board Of Regents, The University Of Texas System Biocompatible microcapsules
US5529914A (en) 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
US20040195710A1 (en) * 1990-10-15 2004-10-07 Hubbell Jeffrey A. Gels for encapsulation of biological materials
US5462990A (en) * 1990-10-15 1995-10-31 Board Of Regents, The University Of Texas System Multifunctional organic polymers
US5573934A (en) 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
US20040138329A1 (en) * 1992-04-20 2004-07-15 Board Of Regents Of The University Of Texas System Gels for encapsulation of biological materials
EP0762874A4 (en) * 1992-12-30 1997-08-06 Clover Cons Ltd Cytoprotective, biocompatible, retrievable macrocapsule containment systems for biologically active materials
FR2702160B1 (en) * 1993-03-02 1995-06-02 Biovecteurs As Synthetic particulate vectors and method of preparation.
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US5981719A (en) 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US6203759B1 (en) 1996-05-31 2001-03-20 Packard Instrument Company Microvolume liquid handling system
US6521187B1 (en) 1996-05-31 2003-02-18 Packard Instrument Company Dispensing liquid drops onto porous brittle substrates
US6537817B1 (en) 1993-05-31 2003-03-25 Packard Instrument Company Piezoelectric-drop-on-demand technology
US6063911A (en) * 1993-12-01 2000-05-16 Marine Polymer Technologies, Inc. Methods and compositions for treatment of cell proliferative disorders
US5858350A (en) 1993-12-01 1999-01-12 Marine Polymer Technologies Methods and compositions for poly-β-1→4-N-acetylglucosamine cell therapy system
US5532287A (en) * 1994-05-04 1996-07-02 Ciba-Geigy Corporation Radiation cured drug release controlling membrane
US5502042A (en) 1994-07-22 1996-03-26 United States Surgical Corporation Methods and compositions for treating wounds
JP3308742B2 (en) * 1994-11-17 2002-07-29 生化学工業株式会社 Photocrosslinkable hyaluronic acid derivative, crosslinked product thereof and methods for producing them
IT1281886B1 (en) * 1995-05-22 1998-03-03 Fidia Advanced Biopolymers Srl PROCESS FOR THE PREPARATION OF HYDROGELS OBTAINED FROM CHEMICAL DERIVATIVES OF HYALURONIC ACID BY MEANS OF ULTRAVIOLET IRRADIATION AND THEIR
US6214331B1 (en) * 1995-06-06 2001-04-10 C. R. Bard, Inc. Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained
US6565842B1 (en) * 1995-06-07 2003-05-20 American Bioscience, Inc. Crosslinkable polypeptide compositions
US5827707A (en) * 1995-06-07 1998-10-27 Neocrin Company Method for manufacturing minimal volume capsules containing biological materials
US5968393A (en) * 1995-09-12 1999-10-19 Demaline; John Tracey Hot water controller
US5855613A (en) 1995-10-13 1999-01-05 Islet Sheet Medical, Inc. Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change
EP0861270B1 (en) * 1995-11-15 2002-07-24 Seikagaku Corporation Photocured hyaluronic acid gel and method of preparation thereof
US6458889B1 (en) 1995-12-18 2002-10-01 Cohesion Technologies, Inc. Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
US6833408B2 (en) 1995-12-18 2004-12-21 Cohesion Technologies, Inc. Methods for tissue repair using adhesive materials
US7883693B2 (en) 1995-12-18 2011-02-08 Angiodevice International Gmbh Compositions and systems for forming crosslinked biomaterials and methods of preparation of use
PT1704878E (en) 1995-12-18 2013-07-17 Angiodevice Internat Gmbh Crosslinked polymer compositions and methods for their use
AU1855297A (en) * 1996-03-26 1997-10-17 Vivorx Pharmaceuticals, Inc. Storage articles for prolonged viability and function of living cells
SE9601368D0 (en) * 1996-04-11 1996-04-11 Pharmacia Biotech Ab Process for the production of a porous cross-linked polysaccharide gel
DE69721265T2 (en) 1996-07-01 2004-05-06 Universiteit Utrecht HYDROLYZABLE HYDROGELS FOR CONTROLLED RELEASE
US6060534A (en) * 1996-07-11 2000-05-09 Scimed Life Systems, Inc. Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties
US6368356B1 (en) 1996-07-11 2002-04-09 Scimed Life Systems, Inc. Medical devices comprising hydrogel polymers having improved mechanical properties
US20040023375A1 (en) * 2002-07-30 2004-02-05 Precision Therapeutics, Inc. Method for preparing cell cultures from biological specimens for chemotherapeutic and other assays
US5728541A (en) 1996-07-12 1998-03-17 Precision Therapeutics, Inc. Method for preparing cell cultures from biologial specimens for chemotherapeutic and other assays
US20040072722A1 (en) 2002-10-10 2004-04-15 Kornblith Paul L. Methods for assessing efficacy of chemotherapeutic agents
EP0927196B1 (en) * 1996-09-19 2008-11-05 The Regents Of The University Of Michigan Polymers containing polysaccharides such as alginates or modified alginates
EP1806367A3 (en) * 1996-09-19 2007-11-28 The Regents Of The University Of Michigan Polymers containing polysaccharides such as alginates or modified alginates
FR2755976B1 (en) * 1996-11-15 1999-01-15 Idm Immuno Designed Molecules NOVEL COMPLEXES OF NUCLEIC ACIDS AND POLYMER SUBSTITUTED BY RESIDUES CAUSING THE DESTABILIZATION OF CELL MEMBRANES
FR2755856B1 (en) * 1996-11-21 1999-01-29 Merck Clevenot Laboratoires MICROCAPSULES OF CHINA OR CHINA DERIVATIVES CONTAINING A HYDROPHOBIC SUBSTANCE, IN PARTICULAR A SUN FILTER AND PROCESS FOR PREPARING SUCH MICROCAPSULES
KR100430625B1 (en) * 1997-01-30 2004-06-16 주식회사 코오롱 Fiber product having excellent antibacterial properties and production thereof
US7105724B2 (en) 1997-04-04 2006-09-12 Board Of Regents Of University Of Nebraska Methods and materials for making and using transgenic dicamba-degrading organisms
US6224893B1 (en) 1997-04-11 2001-05-01 Massachusetts Institute Of Technology Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering
US6656508B2 (en) * 1997-04-17 2003-12-02 Amgen Inc. Sustained-release alginate gels
GB9710049D0 (en) * 1997-05-19 1997-07-09 Nycomed Imaging As Method
US5861149A (en) * 1997-06-04 1999-01-19 Polyheal Ltd. Methods for wound treatment
ES2184294T3 (en) * 1997-06-26 2003-04-01 Smith & Nephew PRODUCTS BASED ON CELL CULTURES.
US6146771A (en) 1997-07-01 2000-11-14 Terumo Cardiovascular Systems Corporation Process for modifying surfaces using the reaction product of a water-insoluble polymer and a polyalkylene imine
US7923250B2 (en) 1997-07-30 2011-04-12 Warsaw Orthopedic, Inc. Methods of expressing LIM mineralization protein in non-osseous cells
EP1007673B1 (en) 1997-07-30 2008-12-17 Emory University Novel bone mineralization proteins, dna, vectors, expression systems
US6121027A (en) * 1997-08-15 2000-09-19 Surmodics, Inc. Polybifunctional reagent having a polymeric backbone and photoreactive moieties and bioactive groups
US6506895B2 (en) 1997-08-15 2003-01-14 Surmodics, Inc. Photoactivatable nucleic acids
US6958148B1 (en) * 1998-01-20 2005-10-25 Pericor Science, Inc. Linkage of agents to body tissue using microparticles and transglutaminase
US6410044B1 (en) 1998-03-19 2002-06-25 Surmodics, Inc. Crosslinkable macromers
US7547445B2 (en) * 1998-03-19 2009-06-16 Surmodics, Inc. Crosslinkable macromers
US6007833A (en) * 1998-03-19 1999-12-28 Surmodics, Inc. Crosslinkable macromers bearing initiator groups
US7060469B2 (en) * 1998-04-02 2006-06-13 The Board Of Regents Of The University Of Oklahoma Polymer grafting by polysaccharide synthases
DE19818077A1 (en) * 1998-04-22 1999-10-28 Biotechnolog Forschung Gmbh Fixing substrate molecules in gel matrixes
AU2003200609B2 (en) * 1998-05-18 2006-02-23 Amgen Inc. Biodegradable sustained-release alginate gels
US6432449B1 (en) * 1998-05-18 2002-08-13 Amgen Inc. Biodegradable sustained-release alginate gels
US6368866B1 (en) 1998-08-03 2002-04-09 Reference Diagnostics, Inc. Rapid separation assay for total iron binding capacity
US6238677B1 (en) * 1998-08-18 2001-05-29 The United States Of America As Represented By The Secretary Of Agriculture Starch microcapsules for delivery of active agents
US6350527B1 (en) * 1998-08-27 2002-02-26 Eidgenossische Technische Hochschule Zurich Gels and multilayer surface structures from boronic acid containing polymers
DE69925757T2 (en) * 1998-08-31 2006-03-23 Cornell Research Foundation, Inc. DEXTRAN MALEIC ACID MONOESTER AND HYDROGELES THEREOF
CA2351593C (en) * 1998-11-11 2012-02-21 The Board Of Regents Of The University Of Oklahoma Polymer grafting by polysaccharide synthases
US20060105431A1 (en) * 1998-11-11 2006-05-18 Deangelis Paul L Polymer grafting by polysaccharide synthases using artificial sugar acceptors
US7375096B1 (en) * 1998-12-04 2008-05-20 California Institute Of Technology Method of preparing a supramolecular complex containing a therapeutic agent and a multi-dimensional polymer network
SE523817C2 (en) * 1999-02-05 2004-05-18 Corline Systems Ab Use of a coagulation prevention agent in conjunction with transplantation of insulin-producing cells
US6410519B1 (en) 1999-03-04 2002-06-25 United States Surgical Corporation Scar reduction
US6495161B1 (en) 1999-03-09 2002-12-17 Vivorx, Inc. Cytoprotective biocompatible containment systems for biologically active materials and methods of making same
US6365385B1 (en) 1999-03-22 2002-04-02 Duke University Methods of culturing and encapsulating pancreatic islet cells
US6303355B1 (en) 1999-03-22 2001-10-16 Duke University Method of culturing, cryopreserving and encapsulating pancreatic islet cells
US7642071B2 (en) 1999-04-01 2010-01-05 The Board Of Regents Of The University Of Oklahoma Methods of expressing gram-negative glycosaminoglycan synthase genes in gram-positive hosts
WO2000060956A1 (en) * 1999-04-12 2000-10-19 Cornell Research Foundation, Inc. Hydrogel-forming system with hydrophobic and hydrophilic components
US6716445B2 (en) * 1999-04-12 2004-04-06 Cornell Research Foundation, Inc. Hydrogel entrapping therapeutic agent and stent with coating comprising this
US6852334B1 (en) * 1999-04-20 2005-02-08 The University Of British Columbia Cationic peg-lipids and methods of use
US6514535B2 (en) * 1999-05-21 2003-02-04 Noveon Ip Holdings Corp. Bioadhesive hydrogels with functionalized degradable crosslinks
EP1064913B1 (en) 1999-07-02 2005-09-14 Cognis IP Management GmbH Microcaspules
ATE258777T1 (en) * 1999-07-02 2004-02-15 Cognis Iberia Sl MICRO CAPSULES - II
US8188043B2 (en) * 1999-07-28 2012-05-29 The Board Of Trustees Of The Leland Stanford Jr. University Nicotine in therapeutic angiogenesis and vasculogenesis
JP2001037472A (en) * 1999-07-28 2001-02-13 Bio Quest:Kk Three dimensional cell-culturing base medium and cell culture using the same
JP2003508127A (en) * 1999-08-27 2003-03-04 デパートメント オブ ナショナル ディフェンス Hydrogel wound dressing containing liposome-encapsulated therapeutic agent
US6369037B1 (en) 1999-10-19 2002-04-09 Cornell Research Foundation, Inc. Controlled release of doxorubicin
US7534589B2 (en) * 1999-11-10 2009-05-19 The Board Of Regents Of The University Of Oklahoma Polymer grafting by polysaccharide synthases
US6753179B2 (en) * 1999-12-08 2004-06-22 Allmighty Co., Ltd. Method for purification treatment of environmental pollutants
US7070807B2 (en) * 1999-12-29 2006-07-04 Mixson A James Branched histidine copolymers and methods for using same
US8642051B2 (en) * 2000-03-21 2014-02-04 Suzanne Jaffe Stillman Method of hydration; infusion packet system(s), support member(s), delivery system(s), and method(s); with business model(s) and Method(s)
US7189705B2 (en) * 2000-04-20 2007-03-13 The University Of British Columbia Methods of enhancing SPLP-mediated transfection using endosomal membrane destabilizers
US6596310B1 (en) 2000-08-23 2003-07-22 Board Of Trustees Operating Michigan State University Method of artificial insemination by timed release of sperm from capsules or solid beads
US7625580B1 (en) * 2000-11-28 2009-12-01 Massachusetts Institute Of Technology Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering
JP4430254B2 (en) * 2001-01-31 2010-03-10 関西ペイント株式会社 Method for producing granular molded article for microbial cell immobilization
US6913765B2 (en) 2001-03-21 2005-07-05 Scimed Life Systems, Inc. Controlling resorption of bioresorbable medical implant material
KR100457546B1 (en) * 2001-05-02 2004-11-18 주식회사 바이오프로젠 A microsphere and process for producting thereof using polyfructose and its derivatives
US8101196B2 (en) * 2001-06-26 2012-01-24 Biointeractions, Ltd. Polysaccharide biomaterials and methods of use thereof
MY169670A (en) * 2003-09-03 2019-05-08 Tibotec Pharm Ltd Combinations of a pyrimidine containing nnrti with rt inhibitors
EP1306128A1 (en) * 2001-10-29 2003-05-02 Tenaxis Gmbh Sorptive composite materials
DE10157046A1 (en) * 2001-11-18 2003-06-12 Novosom Ag Nano and microcapsules comprising reactive polymers
US6809231B2 (en) * 2001-11-21 2004-10-26 The United States Of America As Represented By The Secretary Of Agriculture Flexible and absorbent alginate wound dressing
US20040266026A1 (en) * 2002-01-10 2004-12-30 Amiji Mansoor M. Hybrid immobilized catalytic system with controlled permeability
US20050260259A1 (en) * 2004-04-23 2005-11-24 Bolotin Elijah M Compositions for treatment with glucagon-like peptide, and methods of making and using the same
US7635463B2 (en) * 2002-02-27 2009-12-22 Pharmain Corporation Compositions for delivery of therapeutics and other materials
DE60335608D1 (en) * 2002-02-27 2011-02-17 Pharmain Corp COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS AND OTHER MATERIALS AND METHOD FOR THE PRODUCTION AND USE THEREOF
US20040009210A1 (en) * 2002-07-09 2004-01-15 Kimberly-Clark Worldwide, Inc. Wound management products incorporating cationic compounds
US20040009141A1 (en) * 2002-07-09 2004-01-15 Kimberly-Clark Worldwide, Inc. Skin cleansing products incorporating cationic compounds
US7846141B2 (en) 2002-09-03 2010-12-07 Bluesky Medical Group Incorporated Reduced pressure treatment system
BRPI0314042B8 (en) 2002-09-06 2021-05-25 Calando Pharmaceuticals Inc cyclodextrin-based polymers for the delivery of covalently linked therapeutic agents
US7862831B2 (en) * 2002-10-09 2011-01-04 Synthasome, Inc. Method and material for enhanced tissue-biomaterial integration
US8673333B2 (en) * 2002-09-25 2014-03-18 The Johns Hopkins University Cross-linked polymer matrices, and methods of making and using same
US20050069572A1 (en) * 2002-10-09 2005-03-31 Jennifer Elisseeff Multi-layered polymerizing hydrogels for tissue regeneration
BR0315130A (en) 2002-10-11 2005-08-16 Novocell Inc Therapeutically effective cell therapy and biological material encapsulation compositions, their method and use
ATE457716T1 (en) 2002-12-30 2010-03-15 Angiotech Int Ag RELEASE OF ACTIVE INGREDIENTS FROM QUICK-GELLING POLYMER COMPOSITION
US7008476B2 (en) * 2003-06-11 2006-03-07 Az Electronic Materials Usa Corp. Modified alginic acid of alginic acid derivatives and thermosetting anti-reflective compositions thereof
US20050208095A1 (en) * 2003-11-20 2005-09-22 Angiotech International Ag Polymer compositions and methods for their use
FR2862980B1 (en) * 2003-11-28 2006-03-03 Biopredic Internat MEANS FOR TRANSPORTING AND PRESERVING LIVING CELLS OR FABRICS
GB2408741B (en) 2003-12-04 2008-06-18 Ind Tech Res Inst Hyaluronic acid derivative with urethane linkage
US8313765B2 (en) * 2003-12-04 2012-11-20 Industrial Technology Research Institute Biodegradable hyaluronic acid derivative, biodegradable polymeric micelle composition and pharmaceutical or bioactive composition
US8062272B2 (en) 2004-05-21 2011-11-22 Bluesky Medical Group Incorporated Flexible reduced pressure treatment appliance
US10058642B2 (en) 2004-04-05 2018-08-28 Bluesky Medical Group Incorporated Reduced pressure treatment system
US7909805B2 (en) 2004-04-05 2011-03-22 Bluesky Medical Group Incorporated Flexible reduced pressure treatment appliance
GB0409446D0 (en) 2004-04-28 2004-06-02 Smith & Nephew Apparatus
KR101148445B1 (en) 2004-04-28 2012-07-05 안지오디바이스 인터내셔널 게엠베하 Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
JP5026956B2 (en) * 2004-05-12 2012-09-19 サーモディクス，インコーポレイティド Natural biodegradable polysaccharide coating for medical devices
EP1595534A1 (en) * 2004-05-13 2005-11-16 Universiteit Utrecht Holding B.V. Gel composition comprising charged polymers
DK1796747T3 (en) * 2004-08-27 2017-10-16 Antonio Lauto BIOADHASIVE MOVIE FOR TISSUE REPAIR
CA2581093C (en) 2004-09-17 2014-11-18 Angiotech Biomaterials Corporation Multifunctional compounds for forming crosslinked biomaterials and methods of preparation and use
US9012506B2 (en) 2004-09-28 2015-04-21 Atrium Medical Corporation Cross-linked fatty acid-based biomaterials
EP1811933B1 (en) 2004-09-28 2016-03-23 Atrium Medical Corporation Barrier layer
US9000040B2 (en) 2004-09-28 2015-04-07 Atrium Medical Corporation Cross-linked fatty acid-based biomaterials
WO2006089119A2 (en) * 2005-02-18 2006-08-24 Cartilix, Inc. Biological adhesive
US9119901B2 (en) * 2005-04-28 2015-09-01 Warsaw Orthopedic, Inc. Surface treatments for promoting selective tissue attachment to medical impants
US8414907B2 (en) 2005-04-28 2013-04-09 Warsaw Orthopedic, Inc. Coatings on medical implants to guide soft tissue healing
CA2620936A1 (en) * 2005-09-01 2007-03-08 Precision Therapeutics, Inc. Chemo-sensitivity assays using tumor cells exhibiting persistent phenotypic characteristics
WO2007040557A1 (en) 2005-09-21 2007-04-12 Surmodics, Inc. Coatings and articles including natural biodegradable polysaccharides
JP5226517B2 (en) * 2005-09-21 2013-07-03 サーモディクス，インコーポレイティド In vivo formed matrices containing natural biodegradable polysaccharides and their ocular use
US9278161B2 (en) 2005-09-28 2016-03-08 Atrium Medical Corporation Tissue-separating fatty acid adhesion barrier
US9427423B2 (en) * 2009-03-10 2016-08-30 Atrium Medical Corporation Fatty-acid based particles
GB2432790A (en) * 2005-12-01 2007-06-06 David William Richardson A wound dressing with active ingredients
KR101872061B1 (en) 2005-12-19 2018-06-27 파마인 코포레이션 Hydrophobic core carrier compositions for delivery of therapeutic agents, methods of making and using the same
CN101405303B (en) * 2006-03-14 2011-11-23 诺维信生物制药丹麦公司 Acrylated hyaluronic acid
US20070280986A1 (en) * 2006-06-01 2007-12-06 Carlos Gil Intra-operative coating of implants
WO2007146319A2 (en) * 2006-06-13 2007-12-21 Symphony Medical, Inc. Methods and apparatus for using polymer-based beads and hydrogels for cardiac applications
US20100038311A1 (en) * 2006-07-06 2010-02-18 Hitachi Plant Technologies, Ltd. Entrapping immobilization pellets, wastewater treatment system using the entrapping immobilization pellets and wastewater treatment method
US20080089923A1 (en) * 2006-09-29 2008-04-17 Burkstrand Michael J Biodegradable ocular implants and methods for treating ocular conditions
US20080248108A1 (en) * 2006-10-06 2008-10-09 Jain Krotz Multilayered polyelectrolyte-based capsules for cell encapsulation and delivery of therapeutic compositions
KR100852889B1 (en) 2006-11-07 2008-08-19 이석근 Algin-Cellulose Hybrid and method of the same that
WO2008073295A2 (en) * 2006-12-07 2008-06-19 Surmodics, Inc. Latent stabilization of bioactive agents releasable from implantable medical articles
US20080176958A1 (en) 2007-01-24 2008-07-24 Insert Therapeutics, Inc. Cyclodextrin-based polymers for therapeutics delivery
TWI494133B (en) * 2007-03-14 2015-08-01 Tibotec Pharm Ltd Powders for reconstitution
US7960336B2 (en) 2007-08-03 2011-06-14 Pharmain Corporation Composition for long-acting peptide analogs
US8563527B2 (en) 2007-08-20 2013-10-22 Pharmain Corporation Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same
KR20100049084A (en) 2007-08-23 2010-05-11 인트렉손 코포레이션 Methods and compositions for diagnosing disease
US20110136935A1 (en) * 2007-08-30 2011-06-09 National University Of Singapore Bone and/or dental cement composition and uses thereof
EP2185637B1 (en) 2007-09-19 2013-04-03 SurModics, Inc. Biocompatible foams, systems, and methods
NZ584848A (en) 2007-09-28 2012-09-28 Intrexon Corp Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof
CN101172168B (en) * 2007-10-10 2010-06-02 大连理工大学 Metallic blood vessel bracket coating for osamine glycan load CD133 antibody and method for preparing the same
EP2217298B1 (en) 2007-11-21 2015-11-11 T.J. Smith & Nephew Limited Suction device and dressing
DK3000448T3 (en) 2007-11-21 2019-01-21 Smith & Nephew Wound dressing
GB0722820D0 (en) 2007-11-21 2008-01-02 Smith & Nephew Vacuum assisted wound dressing
GB0723875D0 (en) 2007-12-06 2008-01-16 Smith & Nephew Wound management
US11253399B2 (en) 2007-12-06 2022-02-22 Smith & Nephew Plc Wound filling apparatuses and methods
US20090176892A1 (en) * 2008-01-09 2009-07-09 Pharmain Corporation Soluble Hydrophobic Core Carrier Compositions for Delivery of Therapeutic Agents, Methods of Making and Using the Same
US20090196854A1 (en) * 2008-02-04 2009-08-06 Kytos Biosystems S.A. Methods and compositions for use of crl 5803 cells for expression of biotherapeutics and encapsulated cell-based delivery
US20090202642A1 (en) * 2008-02-08 2009-08-13 Xiao Huang Drug Delivery System Comprising Microparticles and Gelation System
GB0803564D0 (en) 2008-02-27 2008-04-02 Smith & Nephew Fluid collection
US20090238815A1 (en) * 2008-03-18 2009-09-24 Medtronic Vascular, Inc. Nondegradable Hydrogels For Medical Device Application
EP2271416A4 (en) * 2008-04-25 2012-07-04 Biocius Life Sciences Inc Separation cartridges and methods for fabrication and use thereof
WO2009137689A2 (en) * 2008-05-07 2009-11-12 Surmodics, Inc. Delivery of nucleic acid complexes from particles
US9694055B2 (en) 2008-05-09 2017-07-04 Wake Forest University Health Sciences Renal tissue regeneration
US20090294049A1 (en) * 2008-06-02 2009-12-03 Medtronic Vascular, Inc. Biodegradable Adhesive Hydrogels
US20110182957A1 (en) * 2008-06-19 2011-07-28 Nicoll Steven B Cellulosics for tissue replacement
US9392788B2 (en) * 2008-11-07 2016-07-19 North Carolina State University Mosquito attractant compositions and methods
US9193948B2 (en) 2008-11-12 2015-11-24 The Trustees Of The University Of Pennsylvania Biomaterials for tissue replacement
US9198872B2 (en) 2008-12-08 2015-12-01 University Of Miami Dendritic and hyperbranched polymers for cellular encapsulation and functionalization
US8728520B2 (en) * 2008-12-08 2014-05-20 University Of Miami Cross-linked alginate-polyalkylene glycol polymer coatings for encapsulation and methods of making the same
WO2010083039A1 (en) * 2009-01-14 2010-07-22 Cornell University Preparing biodgradable hydrogel for biomedical application
US9259507B2 (en) * 2009-04-21 2016-02-16 Warsaw Orthopedic, Inc. Tissue augmentation with active agent for wound healing
US20110038910A1 (en) 2009-08-11 2011-02-17 Atrium Medical Corporation Anti-infective antimicrobial-containing biomaterials
US9006182B2 (en) * 2009-11-10 2015-04-14 Conversion Energy Enterprises, Inc. Light activated composite tissue adhesives
CA2781669A1 (en) * 2009-11-23 2011-05-26 Cerulean Pharma Inc. Cyclodextrin-based polymers for therapeutic delivery
US8784858B2 (en) 2009-12-21 2014-07-22 Janssen R&D Ireland Degradable removable implant for the sustained release of an active compound
US8790621B2 (en) * 2010-04-12 2014-07-29 Iowa State University Research Foundation, Inc. Nanoparticles and nanoparticle compositions
US9061095B2 (en) 2010-04-27 2015-06-23 Smith & Nephew Plc Wound dressing and method of use
EP2593141B1 (en) 2010-07-16 2018-07-04 Atrium Medical Corporation Composition and methods for altering the rate of hydrolysis of cured oil-based materials
DE102010040687A1 (en) * 2010-09-14 2012-03-15 Hamilton Bonaduz Ag Process for producing active agent beads
US9012406B2 (en) 2010-11-10 2015-04-21 Conversion Energy Enterprises, Inc. Light activated composite tissue adhesives
FR2967677B1 (en) * 2010-11-18 2014-05-16 Centre Nat Rech Scient POLYSACCHARIDE DERIVATIVES COMPRISING ALKENOUS PATTERN AND THIO-CLICK CHEMICAL COUPLING REACTION
GB201020005D0 (en) 2010-11-25 2011-01-12 Smith & Nephew Composition 1-1
EP2643412B1 (en) 2010-11-25 2016-08-17 Smith & Nephew PLC Composition i-ii and products and uses thereof
US8901092B2 (en) 2010-12-29 2014-12-02 Surmodics, Inc. Functionalized polysaccharides for active agent delivery
EP2680862B1 (en) 2011-03-04 2016-07-20 Wake Forest University Health Sciences Encapsulated cells for hormone replacement therapy
FI20115279A0 (en) * 2011-03-22 2011-03-22 Teknologian Tutkimuskeskus Vtt Oy A method of making a hydrogel from a xylan polysaccharide and a hydrogel
CN107412256A (en) 2011-04-15 2017-12-01 海洋聚合物技术公司 Disease is treated with poly- N acetyl glucosamines nanofiber
US9567357B2 (en) 2011-06-24 2017-02-14 Biointeractions Ltd. Biocompatible, biomimetic ampholyte materials
US20150159066A1 (en) 2011-11-25 2015-06-11 Smith & Nephew Plc Composition, apparatus, kit and method and uses thereof
US10226536B2 (en) * 2011-11-28 2019-03-12 Case Western Reserve University Polysaccharide therapeutic conjugates
US10470478B2 (en) * 2012-04-12 2019-11-12 Cure Pharmaceutical Corporation Protein-polysaccharide macromolecular complex article of manufacture containing encapsulated ethyl alcohol
US9867880B2 (en) 2012-06-13 2018-01-16 Atrium Medical Corporation Cured oil-hydrogel biomaterial compositions for controlled drug delivery
WO2014055493A1 (en) 2012-10-02 2014-04-10 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
US20160120706A1 (en) 2013-03-15 2016-05-05 Smith & Nephew Plc Wound dressing sealant and use thereof
US10918765B2 (en) 2013-04-11 2021-02-16 University Of Vermont And State Agricultural College Decellularization and recellularization of whole organs
USRE49528E1 (en) 2013-04-26 2023-05-16 Biointeractions Ltd. Bioactive coatings
CA2910000C (en) 2013-04-26 2023-01-03 Biointeractions Limited Bioactive coating comprising a polymer having both guandine and heparin covalently bonded thereto as pendant groups
UA120037C2 (en) 2013-05-15 2019-09-25 Зе Боард Оф Трастеес Оф Зе Леланд Станфорд Джуніор Юніверсіті Modulation of heparin-binding epidermal growth factor activity for tympanic membrane healing
US10471118B2 (en) 2014-05-30 2019-11-12 Case Western Reserve University Retinylamine derivitives for treatment of ocular disorders
US11129845B2 (en) 2014-06-18 2021-09-28 Case Western Reserve University Compositions and methods for the delivery of nucleic acids
US10925980B2 (en) 2014-08-04 2021-02-23 Case Western Reserve University Molecular probes and methods of use
US11407786B2 (en) 2015-06-18 2022-08-09 Case Western Reserve University Compositions and methods for the delivery of nucleic acids
US9730867B2 (en) 2016-01-06 2017-08-15 The Procter & Gamble Company Methods of forming a slurry with microcapsules formed from phosphate esters
US9732303B2 (en) 2016-01-06 2017-08-15 The Procter & Gamble Company Microcapsules formed from phosphate esters and compositions containing same
US10154947B2 (en) 2016-01-06 2018-12-18 The Procter & Gamble Company Antiperspirant composition
US11655343B2 (en) * 2016-03-24 2023-05-23 Takeda Pharmaceutical Company Limited Alginate hydrogel compositions
US20190076535A1 (en) * 2017-02-20 2019-03-14 Joshua Alan Held Crosslinked protein-polysaccharide complexed consumable macrocapsule
CN110891611B (en) 2017-03-22 2024-03-29 阿森迪斯制药公司 Hydrogel crosslinked hyaluronic acid prodrug compositions and methods
US11794161B1 (en) 2018-11-21 2023-10-24 Trucapsol, Llc Reduced permeability microcapsules
EP3908246A4 (en) 2019-01-11 2022-11-16 Encapsys, LLC Incorporation of chitosan in microcapsule wall
US11571674B1 (en) 2019-03-28 2023-02-07 Trucapsol Llc Environmentally biodegradable microcapsules
US11542392B1 (en) 2019-04-18 2023-01-03 Trucapsol Llc Multifunctional particle additive for enhancement of toughness and degradation in biodegradable polymers
CN111825863B (en) * 2019-04-18 2021-09-28 四川大学 Disulfide bond crosslinked gelatin/epsilon-polylysine active food packaging film and preparation method thereof
US20230002566A1 (en) 2019-12-05 2023-01-05 B.G. Negev Technologies and Application Ltd., at Ben-Gurion University Biodegradable polymeric compositions, methods of preparation and uses thereof
US11465117B2 (en) 2020-01-30 2022-10-11 Trucapsol Llc Environmentally biodegradable microcapsules
WO2022061054A1 (en) * 2020-09-18 2022-03-24 Encapsys, Llc Multifunctional (meth)acrylate polysaccharide microcapsules
KR20230157994A (en) * 2021-03-02 2023-11-17 셀크래프트 엘티디. Method for producing crosslinkable biopolymers
CN113398901B (en) * 2021-05-28 2022-11-08 广西大学 Biomass-based thermosensitive bionic hydrogel adsorption material and preparation method and application thereof
CN113499473B (en) * 2021-06-21 2022-05-10 四川大学 Multifunctional antibacterial dressing, preparation method and application
CN114471707B (en) * 2021-12-23 2023-06-16 中国石油大学(华东) Hydrogel sphere containing catalyst, preparation method thereof and application thereof in photocatalytic treatment of organic pollutants
US11878280B2 (en) 2022-04-19 2024-01-23 Trucapsol Llc Microcapsules comprising natural materials
CN114796597B (en) * 2022-04-24 2023-08-04 福建师范大学 Sphingosine-based hydrogel and preparation method and application thereof
WO2024006528A1 (en) * 2022-07-01 2024-01-04 Sigilon Therapeutics, Inc. Covalently photocrosslinked polysaccharides and methods of use thereof
US11904288B1 (en) 2023-02-13 2024-02-20 Trucapsol Llc Environmentally biodegradable microcapsules

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3332897A (en) * 1964-12-21 1967-07-25 Nat Starch Chem Corp Process of grafting monomers onto polysaccharides, and acylating product to obtain an ester
JPS54128482A (en) * 1978-03-29 1979-10-05 Agency Of Ind Science & Technol Microcapsule and its preparation
US4321117A (en) * 1978-03-09 1982-03-23 Japan Atomic Energy Research Institute Process for preparing a polymer composition
US4605691A (en) * 1984-12-06 1986-08-12 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
US4654233A (en) * 1984-11-21 1987-03-31 Minnesota Mining And Manufacturing Company Radiation-curable thermoplastic coating
US4778880A (en) * 1984-09-28 1988-10-18 Symes Kenneth C Process for producing derivatives of hydroxy compounds, the products and their uses
US4803168A (en) * 1983-09-01 1989-02-07 Damon Biotech, Inc. Microencapsulation with polymers
US4806355A (en) * 1983-06-06 1989-02-21 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US4861629A (en) * 1987-12-23 1989-08-29 Hercules Incorporated Polyfunctional ethylenically unsaturated cellulosic polymer-based photocurable compositions
US5128326A (en) * 1984-12-06 1992-07-07 Biomatrix, Inc. Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3879376A (en) * 1971-05-10 1975-04-22 Oreal Chitosan derivative, method of making the same and cosmetic composition containing the same
US4195129A (en) * 1975-11-26 1980-03-25 Kansai Paint Co., Ltd. Method for immobilizing enzymes and microbial cells
JPS536483A (en) * 1976-07-02 1978-01-20 Tanabe Seiyaku Co Ltd Composition having enzymatic activity and its preparation
US4391909A (en) * 1979-03-28 1983-07-05 Damon Corporation Microcapsules containing viable tissue cells
US4393048A (en) * 1980-02-15 1983-07-12 The United States Of America As Represented By The Secretary Of The Army Protective gel composition for wounds
JPS5923791B2 (en) * 1980-12-23 1984-06-05 旭化成株式会社 Method for producing immobilized microorganisms
US4353888A (en) * 1980-12-23 1982-10-12 Sefton Michael V Encapsulation of live animal cells
CA1196862A (en) * 1983-06-01 1985-11-19 Anthony M.F. Sun Microencapsulation of living tissue and cells
US4689293A (en) * 1983-06-06 1987-08-25 Connaught Laboratories Limited Microencapsulation of living tissue and cells
JPS60100516A (en) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd Preparation of sustained release microcapsule
SE456346B (en) * 1984-07-23 1988-09-26 Pharmacia Ab GEL TO PREVENT ADHESION BETWEEN BODY TISSUE AND SET FOR ITS PREPARATION
US4851521A (en) * 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
SE459005B (en) 1985-07-12 1989-05-29 Aake Rikard Lindahl SET TO MANUFACTURE SPHERICAL POLYMER PARTICLES
JPS62216453A (en) * 1986-03-17 1987-09-24 Mitsubishi Electric Corp Trunk connection system
IT1203814B (en) * 1986-06-30 1989-02-23 Fidia Farmaceutici ESTERS OF ALGINIC ACID
IT1198449B (en) * 1986-10-13 1988-12-21 F I D I Farmaceutici Italiani ESTERS OF POLYVALENT ALCOHOLS OF HYALURONIC ACID
JPS63182302A (en) * 1987-01-23 1988-07-27 Natoko Paint Kk Polymerizable cellulose derivative
US5158881A (en) * 1987-11-17 1992-10-27 Brown University Research Foundation Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
CA2015291C (en) * 1989-04-27 1996-04-30 Etsuo Hasegawa Macromolecular endoplasmic reticulum
EP0426368B1 (en) * 1989-10-31 1995-01-04 Howmedica Inc. Compositions containing derivatives of chitin for preventing adhesion
WO1991009119A1 (en) * 1989-12-13 1991-06-27 Trancel Corporation Improved alginate microcapsules, methods of making and using same
US5084350A (en) * 1990-02-16 1992-01-28 The Royal Institution For The Advance Of Learning (Mcgill University) Method for encapsulating biologically active material including cells
CA2080241A1 (en) * 1990-04-10 1991-10-11 M. Abdul Mazid Nonthrombogenic glycosaminoglycan copolymers
JPH0737750B2 (en) * 1990-09-18 1995-04-26 昭和ロック株式会社 Keyless locking device
US5149543A (en) * 1990-10-05 1992-09-22 Massachusetts Institute Of Technology Ionically cross-linked polymeric microcapsules
US5529914A (en) * 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
US5219895A (en) * 1991-01-29 1993-06-15 Autogenesis Technologies, Inc. Collagen-based adhesives and sealants and methods of preparation and use thereof
US5545423A (en) * 1991-11-25 1996-08-13 Vivorx, Inc. Cytoprotective, biocompatible, retrievable macrocapsule containment systems for biologically active materials
US5334640A (en) * 1992-04-08 1994-08-02 Clover Consolidated, Ltd. Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods
US5550050A (en) * 1994-04-15 1996-08-27 Cytotherapeutics, Inc. Method for implanting encapsulated cells in a host

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3332897A (en) * 1964-12-21 1967-07-25 Nat Starch Chem Corp Process of grafting monomers onto polysaccharides, and acylating product to obtain an ester
US4321117A (en) * 1978-03-09 1982-03-23 Japan Atomic Energy Research Institute Process for preparing a polymer composition
JPS54128482A (en) * 1978-03-29 1979-10-05 Agency Of Ind Science & Technol Microcapsule and its preparation
US4806355A (en) * 1983-06-06 1989-02-21 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US4803168A (en) * 1983-09-01 1989-02-07 Damon Biotech, Inc. Microencapsulation with polymers
US4778880A (en) * 1984-09-28 1988-10-18 Symes Kenneth C Process for producing derivatives of hydroxy compounds, the products and their uses
US4654233A (en) * 1984-11-21 1987-03-31 Minnesota Mining And Manufacturing Company Radiation-curable thermoplastic coating
US4605691A (en) * 1984-12-06 1986-08-12 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
US5128326A (en) * 1984-12-06 1992-07-07 Biomatrix, Inc. Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same
US4861629A (en) * 1987-12-23 1989-08-29 Hercules Incorporated Polyfunctional ethylenically unsaturated cellulosic polymer-based photocurable compositions

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8834451B2 (en) 2002-10-28 2014-09-16 Smith & Nephew Plc In-situ wound cleansing apparatus
US9205001B2 (en) 2002-10-28 2015-12-08 Smith & Nephew Plc Apparatus for aspirating, irrigating and cleansing wounds
US9387126B2 (en) 2002-10-28 2016-07-12 Smith & Nephew Plc Apparatus for aspirating, irrigating and cleansing wounds
US9139664B2 (en) 2007-02-19 2015-09-22 Marine Polymer Technologies, Inc. Hemostatic compositions and therapeutic regimens
US9139663B2 (en) 2007-02-19 2015-09-22 Marine Polymer Technologies, Inc. Hemostatic compositions and therapeutic regimens
US8858964B2 (en) 2010-04-15 2014-10-14 Marine Polymer Technologies, Inc. Anti-bacterial applications of poly-N-acetylglucosamine nanofibers
US9198928B2 (en) 2010-04-15 2015-12-01 Marine Polymer Technologies, Inc. Anti-bacterial applications of poly-N-acetylglucosamine nanofibers
US8998866B2 (en) 2010-07-02 2015-04-07 Smith & Nephew Plc Provision of wound filler

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US5700848A (en) 1997-12-23
US5837747A (en) 1998-11-17
EP0610441A4 (en) 1996-01-10
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US5846530A (en) 1998-12-08
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US5705270A (en) 1998-01-06

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