WO1993018137A1 - Culturing of hematopoietic stem cells and their genetic engineering - Google Patents
Culturing of hematopoietic stem cells and their genetic engineering Download PDFInfo
- Publication number
- WO1993018137A1 WO1993018137A1 PCT/US1993/001852 US9301852W WO9318137A1 WO 1993018137 A1 WO1993018137 A1 WO 1993018137A1 US 9301852 W US9301852 W US 9301852W WO 9318137 A1 WO9318137 A1 WO 9318137A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cells
- medium
- stem cells
- cell
- human hematopoietic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2303—Interleukin-3 (IL-3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2306—Interleukin-6 (IL-6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/235—Leukemia inhibitory factor [LIF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1394—Bone marrow stromal cells; whole marrow
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Developmental Biology & Embryology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019940703107A KR950700403A (en) | 1992-03-04 | 1993-03-03 | CULTURING OF HEMATOPOIETIC STEM CELLS AND THEIR GENETIC ENGINEERING |
EP93907130A EP0631618A4 (en) | 1992-03-04 | 1993-03-03 | Culturing of hematopoietic stem cells and their genetic engineering. |
JP5515827A JPH07504331A (en) | 1992-03-04 | 1993-03-03 | Culture of hematopoietic stem cells and their genetic engineering |
AU37839/93A AU680406B2 (en) | 1992-03-04 | 1993-03-03 | Culturing of hematopoietic stem cells and their genetic engineering |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84678292A | 1992-03-04 | 1992-03-04 | |
US07/846,782 | 1992-03-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1993018137A1 true WO1993018137A1 (en) | 1993-09-16 |
Family
ID=25298935
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1993/001852 WO1993018137A1 (en) | 1992-03-04 | 1993-03-03 | Culturing of hematopoietic stem cells and their genetic engineering |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0631618A4 (en) |
JP (1) | JPH07504331A (en) |
KR (1) | KR950700403A (en) |
AU (2) | AU680406B2 (en) |
CA (1) | CA2131368A1 (en) |
WO (1) | WO1993018137A1 (en) |
Cited By (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5399493A (en) * | 1989-06-15 | 1995-03-21 | The Regents Of The University Of Michigan | Methods and compositions for the optimization of human hematopoietic progenitor cell cultures |
US5437994A (en) * | 1989-06-15 | 1995-08-01 | Regents Of The University Of Michigan | Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells |
WO1996009400A1 (en) * | 1994-09-19 | 1996-03-28 | Systemix, Inc. | Methods for genetically modifying hematopoietic stem cells |
WO1996021004A1 (en) * | 1994-12-30 | 1996-07-11 | Boehringer Ingelheim International Gmbh | Methods for producing differentiated cells from immature hematopoietic cells |
WO1996033281A1 (en) * | 1995-04-20 | 1996-10-24 | Chiron Corporation | High efficiency ex vivo transduction of hematopoietic stem cells by recombinant retroviral preparations |
US5605822A (en) * | 1989-06-15 | 1997-02-25 | The Regents Of The University Of Michigan | Methods, compositions and devices for growing human hematopoietic cells |
US5631219A (en) * | 1994-03-08 | 1997-05-20 | Somatogen, Inc. | Method of stimulating hematopoiesis with hemoglobin |
WO1997018298A1 (en) * | 1995-11-14 | 1997-05-22 | Regents Of The University Of Minnesota | Ex vivo culture of stem cells |
US5635386A (en) * | 1989-06-15 | 1997-06-03 | The Regents Of The University Of Michigan | Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture |
WO1997029183A2 (en) * | 1996-02-08 | 1997-08-14 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Methods and compositions for transforming dendritic cells and activating t cells |
WO1997032992A1 (en) * | 1996-03-07 | 1997-09-12 | Amba Biosciences, L.L.C. | Immortalized hematopoietic cell lines, cell system thereof with stromal cells, in vitro, ex vivo and in vivo uses, and in vitro generation of dendritic cells and macrophages |
US5728581A (en) * | 1995-06-07 | 1998-03-17 | Systemix, Inc. | Method of expanding hematopoietic stem cells, reagents and bioreactors for use therein |
EP0873049A1 (en) * | 1995-09-29 | 1998-10-28 | Indiana University Foundation | Methods for enhanced virus-mediated dna transfer using molecules with virus- and cell-binding domains |
WO1999022001A1 (en) * | 1997-10-28 | 1999-05-06 | Kirin Beer Kabushiki Kaisha | Method for regulating the differentiation/proliferation of hematopoietic stem cells |
WO1999053022A2 (en) * | 1995-12-29 | 1999-10-21 | University Of Edinburgh | Selection of lineage specific cells after differentiation of progenitor cells |
WO1999061644A1 (en) * | 1998-05-29 | 1999-12-02 | Case Western Reserve University | Hematopoietic progenitor cell gene transduction |
WO2000050568A2 (en) * | 1999-02-24 | 2000-08-31 | Reneuron Limited | Transplantation of haematopoietic cells |
WO2000070022A2 (en) * | 1999-05-14 | 2000-11-23 | City Of Hope | Ex vivo expansion of mammalian hematopoietic stem cells |
WO2001032841A2 (en) * | 1999-10-29 | 2001-05-10 | The Government Of The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services | Method of in vitro t cell differentiation of cd34+ progenitor cells |
US6242417B1 (en) | 1994-03-08 | 2001-06-05 | Somatogen, Inc. | Stabilized compositions containing hemoglobin |
US6734014B1 (en) | 1996-02-08 | 2004-05-11 | The United States Of America As Represented By The Department Of Health And Human Services | Methods and compositions for transforming dendritic cells and activating T cells |
US6835566B2 (en) | 1998-02-23 | 2004-12-28 | Aastrom Biosciences, Inc. | Human lineage committed cell composition with enhanced proliferative potential, biological effector function, or both; methods for obtaining same; and their uses |
US7048921B2 (en) | 1995-09-12 | 2006-05-23 | Reneuron Limited | Neural transplantation using pluripotent neuroepithelial cells |
US7083979B1 (en) | 1994-03-25 | 2006-08-01 | Indiana University Foundation | Methods for enhanced retroviral-mediated gene transfer |
US7416888B2 (en) | 2004-09-30 | 2008-08-26 | Reneuron Limited | Cell lines |
WO2014135924A1 (en) | 2013-03-08 | 2014-09-12 | Cells For Cells | Menstrual stems cells for the efficient support and expansion of cd34+ cd133+ hematopoietic stem cells in vitro |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992001040A1 (en) * | 1990-07-09 | 1992-01-23 | Amrad Corporation Limited | Enhanced implantation, development and maintenance of embryos using leukaemia inhibitory factor |
-
1993
- 1993-03-03 WO PCT/US1993/001852 patent/WO1993018137A1/en not_active Application Discontinuation
- 1993-03-03 CA CA002131368A patent/CA2131368A1/en not_active Abandoned
- 1993-03-03 EP EP93907130A patent/EP0631618A4/en not_active Withdrawn
- 1993-03-03 AU AU37839/93A patent/AU680406B2/en not_active Ceased
- 1993-03-03 KR KR1019940703107A patent/KR950700403A/en not_active Application Discontinuation
- 1993-03-03 JP JP5515827A patent/JPH07504331A/en active Pending
-
1997
- 1997-10-31 AU AU43690/97A patent/AU4369097A/en not_active Abandoned
Non-Patent Citations (7)
Title |
---|
Blood, Volume 76, No. 6, issued 15 September 1990, F.A. FLETCHER et al., "Murine Leukemia Inhibitory Factor Enhances Retroviral-Vector Infection Efficiency of Hematopoietic Progenitors", pages 1098-1103, see especially page 1099. * |
Blood, Volume 77, No. 2, issued 15 January 1991, C. VERFAILLIE et al., "Leukemia Inhibitory Factor/Human Interleukin for DA Cells: A Growth Factor that Stimulates the In Vitro Development of Multipotential Human Hematopoietic Progenitors", pages 263-270, see entire document. * |
Gene, Volume 84, issued 1989, D. VALERIO, "Retrovirus-Mediated Gene Transfer into Embryonal Carcinoma and Hematopoietic Stem Cells: Expression from a Hybrid Long Terminal Repeat", pages 419-427, see entire document. * |
Journal of Experimental Medicine, Volume 172, issued September 1990, V.W. VAN BEUSECHEM et al., "Expression of Human Adenosine Deaminase in Mice Transplanted with Hematopoietic Stem Cells Infected with Amphotropic Retroviruses", pages 729-736, see entire document. * |
Nature, Volume 336, issued 15 December 1988, J.-F. MOREAU et al., "Leukaemia Inhibitory Factor is Identical to the Myeloid Growth Factor Human Interleukin for DA Cells", pages 690-692, see entire document. * |
R.I. FRESHNEY, "Culture of Animal Cells: A Manual of Basic Techniques", published 1987 by Alan R. Liss, Inc. (N.Y.), see pages 60-61, 139-140. * |
See also references of EP0631618A4 * |
Cited By (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6667034B2 (en) | 1989-06-15 | 2003-12-23 | The Regents Of The University Of Michigan | Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture, methods for assaying the effect of substances on lineage-specific cell production, and cell compositions produced by these cultures |
US5437994A (en) * | 1989-06-15 | 1995-08-01 | Regents Of The University Of Michigan | Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells |
US5399493A (en) * | 1989-06-15 | 1995-03-21 | The Regents Of The University Of Michigan | Methods and compositions for the optimization of human hematopoietic progenitor cell cultures |
US5635386A (en) * | 1989-06-15 | 1997-06-03 | The Regents Of The University Of Michigan | Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture |
US5605822A (en) * | 1989-06-15 | 1997-02-25 | The Regents Of The University Of Michigan | Methods, compositions and devices for growing human hematopoietic cells |
US6242417B1 (en) | 1994-03-08 | 2001-06-05 | Somatogen, Inc. | Stabilized compositions containing hemoglobin |
US5631219A (en) * | 1994-03-08 | 1997-05-20 | Somatogen, Inc. | Method of stimulating hematopoiesis with hemoglobin |
US7083979B1 (en) | 1994-03-25 | 2006-08-01 | Indiana University Foundation | Methods for enhanced retroviral-mediated gene transfer |
US7759467B2 (en) | 1994-03-25 | 2010-07-20 | Indiana University Research And Technology Corporation | Enhanced mediated DNA transfer |
WO1996009400A1 (en) * | 1994-09-19 | 1996-03-28 | Systemix, Inc. | Methods for genetically modifying hematopoietic stem cells |
US5648248A (en) * | 1994-12-30 | 1997-07-15 | Boehringer Ingelheim International Gmbh | Methods for producing differentiated cells from immature hematopoietic cells |
WO1996021004A1 (en) * | 1994-12-30 | 1996-07-11 | Boehringer Ingelheim International Gmbh | Methods for producing differentiated cells from immature hematopoietic cells |
WO1996033281A1 (en) * | 1995-04-20 | 1996-10-24 | Chiron Corporation | High efficiency ex vivo transduction of hematopoietic stem cells by recombinant retroviral preparations |
US5728581A (en) * | 1995-06-07 | 1998-03-17 | Systemix, Inc. | Method of expanding hematopoietic stem cells, reagents and bioreactors for use therein |
US7048921B2 (en) | 1995-09-12 | 2006-05-23 | Reneuron Limited | Neural transplantation using pluripotent neuroepithelial cells |
US7371374B2 (en) | 1995-09-12 | 2008-05-13 | Reneuron Limited | Neural transplantation using pluripotent neuroepithelial cells |
US8889419B2 (en) | 1995-09-29 | 2014-11-18 | Indiana University Research & Technology Corporation | Methods for enhanced virus-mediated DNA transfer using molecules with virus- and cell-binding domains |
EP0873049A1 (en) * | 1995-09-29 | 1998-10-28 | Indiana University Foundation | Methods for enhanced virus-mediated dna transfer using molecules with virus- and cell-binding domains |
EP0873049A4 (en) * | 1995-09-29 | 1998-12-02 | ||
US5922597A (en) * | 1995-11-14 | 1999-07-13 | Regents Of The University Of Minnesota | Ex vivo culture of stem cells |
WO1997018298A1 (en) * | 1995-11-14 | 1997-05-22 | Regents Of The University Of Minnesota | Ex vivo culture of stem cells |
WO1999053022A2 (en) * | 1995-12-29 | 1999-10-21 | University Of Edinburgh | Selection of lineage specific cells after differentiation of progenitor cells |
WO1999053022A3 (en) * | 1995-12-29 | 2001-04-19 | Univ Edinburgh | Selection of lineage specific cells after differentiation of progenitor cells |
US7378277B2 (en) | 1996-02-08 | 2008-05-27 | The United States Of America As Represented By The Department Of Health And Human Services | Methods and compositions for transforming dendritic cells and activating T cells |
WO1997029183A3 (en) * | 1996-02-08 | 1997-12-18 | Us Health | Methods and compositions for transforming dendritic cells and activating t cells |
WO1997029183A2 (en) * | 1996-02-08 | 1997-08-14 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Methods and compositions for transforming dendritic cells and activating t cells |
US6734014B1 (en) | 1996-02-08 | 2004-05-11 | The United States Of America As Represented By The Department Of Health And Human Services | Methods and compositions for transforming dendritic cells and activating T cells |
WO1997032992A1 (en) * | 1996-03-07 | 1997-09-12 | Amba Biosciences, L.L.C. | Immortalized hematopoietic cell lines, cell system thereof with stromal cells, in vitro, ex vivo and in vivo uses, and in vitro generation of dendritic cells and macrophages |
US5811297A (en) * | 1996-03-07 | 1998-09-22 | Amba Biosciences, Llc | Immortalized hematopoietic cell lines, cell system thereof with stromal cells, in vitro, ex vivo and in vivo uses, & in vitro generation of dendritic cells and macrophages |
WO1999022001A1 (en) * | 1997-10-28 | 1999-05-06 | Kirin Beer Kabushiki Kaisha | Method for regulating the differentiation/proliferation of hematopoietic stem cells |
US6835566B2 (en) | 1998-02-23 | 2004-12-28 | Aastrom Biosciences, Inc. | Human lineage committed cell composition with enhanced proliferative potential, biological effector function, or both; methods for obtaining same; and their uses |
US6929948B1 (en) | 1998-04-14 | 2005-08-16 | The University Court Of The University Of Edinburgh | Lineage specific cells and progenitor cells |
US7781214B2 (en) | 1998-04-14 | 2010-08-24 | The University Court Of The University Of Edinburgh | Lineage specific cells and progenitor cells |
WO1999061644A1 (en) * | 1998-05-29 | 1999-12-02 | Case Western Reserve University | Hematopoietic progenitor cell gene transduction |
WO2000050568A3 (en) * | 1999-02-24 | 2000-12-07 | Reneuron Ltd | Transplantation of haematopoietic cells |
WO2000050568A2 (en) * | 1999-02-24 | 2000-08-31 | Reneuron Limited | Transplantation of haematopoietic cells |
WO2000070022A2 (en) * | 1999-05-14 | 2000-11-23 | City Of Hope | Ex vivo expansion of mammalian hematopoietic stem cells |
WO2000070022A3 (en) * | 1999-05-14 | 2001-05-31 | Hope City | Ex vivo expansion of mammalian hematopoietic stem cells |
WO2001032841A3 (en) * | 1999-10-29 | 2002-02-07 | Us Health | Method of in vitro t cell differentiation of cd34+ progenitor cells |
WO2001032841A2 (en) * | 1999-10-29 | 2001-05-10 | The Government Of The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services | Method of in vitro t cell differentiation of cd34+ progenitor cells |
US7416888B2 (en) | 2004-09-30 | 2008-08-26 | Reneuron Limited | Cell lines |
US7419827B2 (en) | 2004-09-30 | 2008-09-02 | Reneuron Limited | Cell lines |
US7666672B2 (en) | 2004-09-30 | 2010-02-23 | Reneuron Limited | Cell lines |
WO2014135924A1 (en) | 2013-03-08 | 2014-09-12 | Cells For Cells | Menstrual stems cells for the efficient support and expansion of cd34+ cd133+ hematopoietic stem cells in vitro |
Also Published As
Publication number | Publication date |
---|---|
AU4369097A (en) | 1998-02-12 |
CA2131368A1 (en) | 1993-09-16 |
AU680406B2 (en) | 1997-07-31 |
EP0631618A4 (en) | 1995-09-27 |
AU3783993A (en) | 1993-10-05 |
JPH07504331A (en) | 1995-05-18 |
KR950700403A (en) | 1995-01-16 |
EP0631618A1 (en) | 1995-01-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU680406B2 (en) | Culturing of hematopoietic stem cells and their genetic engineering | |
CA2195335C (en) | Human marrow stromal cell lines which sustain hematopoiesis | |
US5061620A (en) | Human hematopoietic stem cell | |
EP0330191B1 (en) | DNA encoding CD40 | |
Whitlock et al. | Murine B cell lymphopoiesis in long term culture | |
Larochelle et al. | Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: implications for gene therapy | |
US6541249B2 (en) | Immortalized human stromal cell lines | |
US5677139A (en) | In vitro differentiation of CD34+ progenitor cells into T lymphocytes | |
US7416887B2 (en) | Methods for use of MPL ligands with primitive human stem cells | |
US5821108A (en) | Enrichment for a thymocyte subset having progenitor cell activity using c-kit as a selection marker | |
WO1997021802A1 (en) | Novel embryonic cell populations and methods to isolate such populations | |
Yamaguchi et al. | Umbilical vein endothelial cells are an important source of c‐kit and stem cell factor which regulate the proliferation of haemopoietic progenitor cells | |
Rios et al. | Systematic analysis of the ability of stromal cell lines derived from different murine adult tissues to support maintenance of hematopoietic stem cells in vitro | |
Kisielow | Applications of fetal thymus organ cultures in studies of T cell development | |
WO2002064756A9 (en) | Stem cell identification | |
WO1994008039A1 (en) | Method of enrichment for human hematopoietic stem cells using c-kit | |
WO2003065986A2 (en) | FcϵRI-BEARING HUMAN MAST CELL LINES | |
WO1997022708A1 (en) | Primate cluster-forming embryonic hematopoietic stem cells | |
WO1994010293A1 (en) | Thymic stromal cell cultures for t-cell differentiation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AU CA JP KR SK |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE |
|
EX32 | Extension under rule 32 effected after completion of technical preparation for international publication |
Free format text: KZ |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2131368 Country of ref document: CA Ref document number: 1993907130 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 1993907130 Country of ref document: EP |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 1993907130 Country of ref document: EP |