WO1993025209A1 - Compositions for the treatment and prophylaxis of inflammations and dermatoses induced by viruses and process for the preparation thereof - Google Patents
Compositions for the treatment and prophylaxis of inflammations and dermatoses induced by viruses and process for the preparation thereof Download PDFInfo
- Publication number
- WO1993025209A1 WO1993025209A1 PCT/HU1993/000038 HU9300038W WO9325209A1 WO 1993025209 A1 WO1993025209 A1 WO 1993025209A1 HU 9300038 W HU9300038 W HU 9300038W WO 9325209 A1 WO9325209 A1 WO 9325209A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compositions
- inflammations
- preparation
- prophylaxis
- treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Definitions
- the invention relates to new cosmetic and/or medicinal compositions which beneficially affect virus-induced infections and inflammations- of the skin and mucosa and promote the regeneration of the dermatoses caused, i.e. the compositions are able to restore the initial conditions of the skin.
- compositions of the invention are special ⁇ ly suitable for the treatment of infections and dermatoses induced by herpes virus.
- the cited patents also confirm that in this field of indication the use of natural substances is becoming popular world-wide, too.
- the present invention is also a representative of this trend of development, and is based on the observation that active ingredient concentrates can be prepared from particular natural substances by a specific process which can be used, alone or in combination, for the production of cosmetic agents or medicinal cosmetics of improved activity. Their activity can be further increased by applying adjuvants or specific formulations.
- the invention relates to compositions of manifold application with viricide, antiinflamma- tory and regenerating activity wherein the concentrations of the ingredients given % by weight are as follows: Glycyrrhizin, preferably in the form of sweet-root extract 0.005-0.4
- Rosemary acid preferably in the form of plant extract 0.005-0.4
- compositions may contain further carriers, additives and auxiliary materials usually applied in the preparation of cosmetic or medicinal compositions, preferably water, propyleneglycol, acrylamide-sodium aerylate copolymer, PEG-7, glycerol cocoate and isooctyl nonanoate, as well as solubilizing agents, lipids, preservatives and fragrance components in hydrogel, lotion-ointment, liquid emulsion, spray, stick or drop formulation.
- auxiliary materials usually applied in the preparation of cosmetic or medicinal compositions, preferably water, propyleneglycol, acrylamide-sodium aerylate copolymer, PEG-7, glycerol cocoate and isooctyl nonanoate, as well as solubilizing agents, lipids, preservatives and fragrance components in hydrogel, lotion-ointment, liquid emulsion, spray, stick or drop formulation.
- rosemary acid (caffeoyl- -hydroxy-dihydrocaffeic acid) , together with quinic acid, chlorogenic acid and caffeic acid, is present in plants of the labiate family (Laminaceae) , mainly in Melissa officinalis, Hyssopus officinalis, Rosmarinus officinalis and Salvia officinalis. Its virostatic, antibacterial and antimycotic potency is reported by I. K. Heimann and . Schultze in the Zeitschrift fur Phythotherapie Sept. 1988, 82-83.
- sweet root (Glycyr- rhiza glabra) extracts are used as sweeteners to improve taste and as expectorants (B. Issekutz: (Drug pres ⁇ cription, Gy ⁇ gyszerrendeles p. 600 Medicina, Budapest, 1979) .
- the regular use of standard preparations may reduce the increased tension of the stomach wall and the inflamination of gastric mucosa (Gizella Verzar Petri: Gy ⁇ gyn ⁇ venyek a gy ⁇ gyaszatban (Medicinal plants in therapy), p. 92, Medicina, Budapest, 1984).
- Russian authors [I. A.
- Glycyr- rhizin the major constituent of sweet root has mineralo- corticoid, antiinflammatory, antiedema and epithelizing (wound healing) properties.
- the volatile oil of thyme (Thymus vulgaris) contains mainly thymol, carvacrol, p-cymol, furthermore linalool, borneol, geraniol and ⁇ - pinene.
- thyme oil Due to its thymol content the thyme oil has viricide effect and inhibits a major part of wound bacteria even at 3000fold dilution (Gizella Verzar Petri: Medicinal plants in therapy, Medicina, Budapest, 1984, p. 74.).
- the ⁇ -bisabolol is one of the major components of camomile (Matricaria chamomilla) . Primarily it has antiinflam atory effect and promotes granulation. The allantoin promotes the skin-regeneration and hydration.
- the collagens which can be found in the skin, also play role in hydration, but based on other mechanism.
- the polydocanol is ingredient of numerous medicinal and cosmetic composition. It has analgetic and local anaesthetic effect.
- An aqeous alcohol (methanol, ethanol, iso- propanol) extract is prepared from the leaves of a plant from Laminaceae family, e.g. rosemary, melilot (Melissa officinalis) , Salvia officinalis and Hyssopus officinalis, etc. After removing the sol ⁇ vent the residue is acidified to pH 2-3 with an inorganic acid, the mixture is extracted with a water immiscible solvent (ether, chloroform, di- chloromethane, ethyl acetate, etc.), the layers are separated and the solvent is removed from the orga ⁇ nic layer yielding a dry extract.
- a water immiscible solvent ether, chloroform, di- chloromethane, ethyl acetate, etc.
- the product is specifically beneficial for symptoms of the mucosa (oral and genital) induced by herpes simplex virus. Applied in the early stage the development of erythema and edema is suppressed and recovery is accelerated. In recurrent cases, applied before the development of symptoms, superinfection is fully inhi- bited. Furthermore, subjective symptoms, such as itching and stretching, are alleviated, and recovery is rapid and traceless. The skin becomes refreshed and hydrated.
- Figure 1 presents the results of the compa- rative study of the preparation of the invention (herpes gel prepared according to procedure 1) and that of the commercial control products, together with the duration of recovery of untreated cases. The following control preparations were tested in the study ( Figure 1 shows the mean values of the results obtained) :
- Medicinal gel and paint formulation containing the extract of 15 % (w/w) Chelidonium herba, 3 % (w/w) Menthae piperita folium, 1 % (w/w) Calendula officinalis, 2 % (w/w) Thy i herba and 2 % (w/w) Millefolii herba, prepared with 50 % (w/w) ethanol.
- Medicinal suspension ointment formulation containing 0.8 % (w/w) of 3-(2-deoxy-D-ribofuranosyl)-5- isopropyluracyl.
- Medicinal alcoholic gel formulation containing 0.2 % (w/w) primicium sulfuricum and 2 % (w/w) lidocain.
- formulations of the preparations according to the invention are listed as follows: in the major part of indications the most advantageous formulation proved to be the rapidly absorbing and penetrating gel form which is easy to handle.
- the formulations specified (1-3) are partly usual gels and partly microemulsions [values in the table are expressed in % by weight (w/w) ] :
- Acrylic acid/Na acrylate copolymer (Hostacerin PN 73) 2.0 1.5 POE(45) hydrogenated ricinol acid triglyceride
- PCL liquid Isooctadecyl isononanoate (PCL liquid) 2.0 0.3
- Thyme- oil 0.02 0.025 0.02 Distilled water ad 100 100 100
- the gels are prepared by dissolving allantoin in the bulk of water, then in some cases (formulations l- 2) also the copolimer, using slow stirring.
- Ointment is also a formulation of choice, see formulations 4 to 6 [values in the table are expressed in % by weight (w/w) ] :
- Ointments are prepared by melting the lipid components and the emulsifier - liquid paraffin, stearin, isooctyl stearate or polyoxyethylene (POE) fatty acid ester, resp. - and heating the mixture to about 70°C. Thereafter the polydocanol is added, and, if desired (formulations 5 and 6) , Irgasan. Allantoin is dissolved in water then the aqueous phase is heated to about 70°C.
- POE polyoxyethylene
- Alcoholic paint, drop or spray are also formulations of choice.
- the composition of formulations 7 to 9 are listed in the following.
- Triclosan (Irgasan OP 300) 0.05 0.1
- the solutions are prepared by solubilizing first the thyme oil, preferably with POE(45) hydrogenated ricinol acid triglyceride. Irgasan is dissolved in alcohol, and allantoin in the bulk of water. The phases prepared in this way are mixed, then, under constant stirring the solution of ⁇ -bisabolol and collagen (formulations 7 and 8) is added to the system, finally the propyleneglycol solution of glycyrrhizin and rosemary acid. Stirring is continued for a couple of minutes after the addition.
- Alcoholic painting composition and aerosol foam or spray composition using an appropriate carrier gas can be also prepared.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU43525/93A AU4352593A (en) | 1992-06-18 | 1993-06-17 | Compositions for the treatment and prophylaxis of inflammations and dermatoses induced by viruses and process for the preparation thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9202040A HU209370B (en) | 1992-06-18 | 1992-06-18 | Preparatives for treatment and preventing inflammations and other damages of skin caused by bacteria, viruses or reactive free radicals of oxygen, as well as method for making said preparatives |
HUP9202040 | 1992-06-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1993025209A1 true WO1993025209A1 (en) | 1993-12-23 |
Family
ID=10982077
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/HU1993/000038 WO1993025209A1 (en) | 1992-06-18 | 1993-06-17 | Compositions for the treatment and prophylaxis of inflammations and dermatoses induced by viruses and process for the preparation thereof |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU4352593A (zh-CN) |
HU (1) | HU209370B (zh-CN) |
WO (1) | WO1993025209A1 (zh-CN) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2287405A (en) * | 1994-03-17 | 1995-09-20 | Fischer Pharma Ltd | Skin whitening compositions containing glycyrrhiza extracts |
US5500448A (en) * | 1993-05-13 | 1996-03-19 | Chesebrough-Pond's Usa Co., Division Of Conopoco, Inc. | Recurrent aphthous ulcer treatment method |
WO1998004276A1 (fr) * | 1996-07-30 | 1998-02-05 | L'oreal | Utilisation dans une composition d'un extrait d'au moins une labiee |
US5945089A (en) * | 1998-11-05 | 1999-08-31 | I-Dent International Corporation | Method of treating mucositis |
EP0992238A1 (en) * | 1998-10-06 | 2000-04-12 | I-Dent International Corporation | Use of triclosan for preventing and treating mucosal and dermal conditions |
US6440395B1 (en) | 1992-06-22 | 2002-08-27 | Barry M. Libin | Antiplaque mouth rinse |
WO2003045349A2 (de) * | 2001-11-27 | 2003-06-05 | Beiersdorf Ag | Juckreizstillende kosmetische und dermatologische zubereitungen |
WO2004075854A2 (en) * | 2003-02-26 | 2004-09-10 | Program For Appropriate Technology In Health | Microbicidal compositions and method of use |
FR2867947A1 (fr) * | 2004-03-29 | 2005-09-30 | Hightech Bio Activities Holdin | Complexe vegetal biodecontaminant presentant a la fois des proprietes bactericides, fongicides et virucides pour le traitement de l'eau |
WO2007110356A1 (en) * | 2006-03-24 | 2007-10-04 | Istituto Farmacoterapico Italiano S.P.A. | Spray composition for topical use for treating and/or preventing herpes simplex labial infections |
WO2016146843A1 (en) * | 2015-03-18 | 2016-09-22 | Bionoox Suisse Sa | Compositions comprising dihydroquercetin for use in methods for treating herpes |
EP3000475A4 (en) * | 2013-05-23 | 2017-01-11 | Kledos Cell Tech, S.L. | Pharmaceutical or cosmetic composition for the regeneration and cicatrisation of the skin |
CN107982521A (zh) * | 2017-12-13 | 2018-05-04 | 罗强 | 一种女性清洁剂及制备方法 |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2071494A (en) * | 1980-03-08 | 1981-09-23 | Maruzen Kasei Co Ltd | Cosmetics containing 18-glycyrrhizins |
JPS5913716A (ja) * | 1982-07-16 | 1984-01-24 | Lion Corp | 外用組成物 |
GB2167296A (en) * | 1982-03-05 | 1986-05-29 | Yissum Res Dev Co | Topical pharmaceutical compositions containing glycyrrhizin |
JPS63188628A (ja) * | 1987-01-30 | 1988-08-04 | Shiseido Co Ltd | 皮膚外用剤 |
FR2614787A1 (fr) * | 1987-05-07 | 1988-11-10 | Pola Kasei Kogyo Kk | Cosmetique pour la peau |
JPH03236323A (ja) * | 1990-02-13 | 1991-10-22 | Kobayashi Kose Co Ltd | 美白用皮膚外用剤 |
JPH0436215A (ja) * | 1990-05-29 | 1992-02-06 | Sunstar Inc | 日焼けに対する消炎性を有する化粧料 |
EP0487404A1 (en) * | 1990-11-19 | 1992-05-27 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | External dermatological composition |
-
1992
- 1992-06-18 HU HU9202040A patent/HU209370B/hu not_active IP Right Cessation
-
1993
- 1993-06-17 AU AU43525/93A patent/AU4352593A/en not_active Abandoned
- 1993-06-17 WO PCT/HU1993/000038 patent/WO1993025209A1/en active Application Filing
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2071494A (en) * | 1980-03-08 | 1981-09-23 | Maruzen Kasei Co Ltd | Cosmetics containing 18-glycyrrhizins |
GB2167296A (en) * | 1982-03-05 | 1986-05-29 | Yissum Res Dev Co | Topical pharmaceutical compositions containing glycyrrhizin |
JPS5913716A (ja) * | 1982-07-16 | 1984-01-24 | Lion Corp | 外用組成物 |
JPS63188628A (ja) * | 1987-01-30 | 1988-08-04 | Shiseido Co Ltd | 皮膚外用剤 |
FR2614787A1 (fr) * | 1987-05-07 | 1988-11-10 | Pola Kasei Kogyo Kk | Cosmetique pour la peau |
JPH03236323A (ja) * | 1990-02-13 | 1991-10-22 | Kobayashi Kose Co Ltd | 美白用皮膚外用剤 |
JPH0436215A (ja) * | 1990-05-29 | 1992-02-06 | Sunstar Inc | 日焼けに対する消炎性を有する化粧料 |
EP0487404A1 (en) * | 1990-11-19 | 1992-05-27 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | External dermatological composition |
Non-Patent Citations (4)
Title |
---|
PATENT ABSTRACTS OF JAPAN, Section C, Volume 12, No. 467, issued 07 December 1988, page 120, C-550; & JP,A,63 188 628, (SHISEIDO CO.). * |
PATENT ABSTRACTS OF JAPAN, Section C, Volume 16, No. 20, issued 20 January 1992, page 17, C-902; & JP,A,03 236 323, (KOBAYASHI KOSE CO LTD). * |
PATENT ABSTRACTS OF JAPAN, Section C, Volume 16, No. 207, issued 18 May 1992, page 23, C-941; & JP,A,04 036 215, (SUNSTAR INC). * |
PATENT ABSTRACTS OF JAPAN, Section C, Volume 8, No. 98, issued 09 May 1984, page 101, C-221; & JP,A,59 013 716. * |
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6440395B1 (en) | 1992-06-22 | 2002-08-27 | Barry M. Libin | Antiplaque mouth rinse |
US5500448A (en) * | 1993-05-13 | 1996-03-19 | Chesebrough-Pond's Usa Co., Division Of Conopoco, Inc. | Recurrent aphthous ulcer treatment method |
GB2287405A (en) * | 1994-03-17 | 1995-09-20 | Fischer Pharma Ltd | Skin whitening compositions containing glycyrrhiza extracts |
GB2287405B (en) * | 1994-03-17 | 1998-08-12 | Fischer Pharma Ltd | Skin whitening compositions comprising glycyrrhiza extracts |
WO1998004276A1 (fr) * | 1996-07-30 | 1998-02-05 | L'oreal | Utilisation dans une composition d'un extrait d'au moins une labiee |
FR2751878A1 (fr) * | 1996-07-30 | 1998-02-06 | Oreal | Utilisation dans une composition d'un extrait d'au moins une labiee |
US6060061A (en) * | 1996-07-30 | 2000-05-09 | Societe L'oreal S.A. | Method for preventing or treating disorders involving an inflammatory process |
EP0992238A1 (en) * | 1998-10-06 | 2000-04-12 | I-Dent International Corporation | Use of triclosan for preventing and treating mucosal and dermal conditions |
US5945089A (en) * | 1998-11-05 | 1999-08-31 | I-Dent International Corporation | Method of treating mucositis |
WO2003045349A3 (de) * | 2001-11-27 | 2003-09-18 | Beiersdorf Ag | Juckreizstillende kosmetische und dermatologische zubereitungen |
WO2003045349A2 (de) * | 2001-11-27 | 2003-06-05 | Beiersdorf Ag | Juckreizstillende kosmetische und dermatologische zubereitungen |
WO2004075854A2 (en) * | 2003-02-26 | 2004-09-10 | Program For Appropriate Technology In Health | Microbicidal compositions and method of use |
WO2004075854A3 (en) * | 2003-02-26 | 2005-10-27 | Program For Appropriate Techno | Microbicidal compositions and method of use |
FR2867947A1 (fr) * | 2004-03-29 | 2005-09-30 | Hightech Bio Activities Holdin | Complexe vegetal biodecontaminant presentant a la fois des proprietes bactericides, fongicides et virucides pour le traitement de l'eau |
WO2007110356A1 (en) * | 2006-03-24 | 2007-10-04 | Istituto Farmacoterapico Italiano S.P.A. | Spray composition for topical use for treating and/or preventing herpes simplex labial infections |
JP2009530350A (ja) * | 2006-03-24 | 2009-08-27 | イスチチュト ファルマコテラピコ イタリアーノ ソシエタ ペル アチオニ | 口唇単純ヘルペス感染症の治療および/または予防のための局所使用用スプレー組成物 |
EP3000475A4 (en) * | 2013-05-23 | 2017-01-11 | Kledos Cell Tech, S.L. | Pharmaceutical or cosmetic composition for the regeneration and cicatrisation of the skin |
WO2016146843A1 (en) * | 2015-03-18 | 2016-09-22 | Bionoox Suisse Sa | Compositions comprising dihydroquercetin for use in methods for treating herpes |
US11077087B2 (en) | 2015-03-18 | 2021-08-03 | Bionoox Suisse Sa | Compositions comprising dihydroquercetin for use in methods for treating herpes |
CN107982521A (zh) * | 2017-12-13 | 2018-05-04 | 罗强 | 一种女性清洁剂及制备方法 |
Also Published As
Publication number | Publication date |
---|---|
HU9202040D0 (en) | 1992-09-28 |
HU209370B (en) | 1994-05-30 |
AU4352593A (en) | 1994-01-04 |
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