WO1994000756A1 - A device for indicating the presence of carbon dioxide in a patient's exhaled air - Google Patents

A device for indicating the presence of carbon dioxide in a patient's exhaled air Download PDF

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Publication number
WO1994000756A1
WO1994000756A1 PCT/SE1993/000554 SE9300554W WO9400756A1 WO 1994000756 A1 WO1994000756 A1 WO 1994000756A1 SE 9300554 W SE9300554 W SE 9300554W WO 9400756 A1 WO9400756 A1 WO 9400756A1
Authority
WO
WIPO (PCT)
Prior art keywords
air
indicator element
passage
heat
flow
Prior art date
Application number
PCT/SE1993/000554
Other languages
French (fr)
Inventor
Andras Gedeon
Original Assignee
Minco Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Minco Ab filed Critical Minco Ab
Priority to EP93915065A priority Critical patent/EP0601171B1/en
Priority to US08/190,189 priority patent/US5468451A/en
Priority to DE69313984T priority patent/DE69313984T2/en
Priority to JP6502261A priority patent/JPH06510690A/en
Publication of WO1994000756A1 publication Critical patent/WO1994000756A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/0004—Gaseous mixtures, e.g. polluted air
    • G01N33/0009—General constructional details of gas analysers, e.g. portable test equipment
    • G01N33/0027—General constructional details of gas analysers, e.g. portable test equipment concerning the detector
    • G01N33/0036—Specially adapted to detect a particular component
    • G01N33/004—Specially adapted to detect a particular component for CO, CO2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/1045—Devices for humidifying or heating the inspired gas by using recovered moisture or heat from the expired gas
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
    • G01N31/223—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators for investigating presence of specific gases or aerosols
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/04—Tracheal tubes
    • A61M16/0402—Special features for tracheal tubes not otherwise provided for
    • A61M16/0411—Special features for tracheal tubes not otherwise provided for with means for differentiating between oesophageal and tracheal intubation
    • A61M2016/0413—Special features for tracheal tubes not otherwise provided for with means for differentiating between oesophageal and tracheal intubation with detectors of CO2 in exhaled gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • A61M2205/584—Means for facilitating use, e.g. by people with impaired vision by visual feedback having a color code

Definitions

  • This invention relates to a device for indicating the presence of carbon dioxide, C0 2 , in the air exhaled by a patient. More particularly, the invention relates to a device of the kind comprising an indicator element which undergoes a reversible change of colour in response to the exposure there ⁇ of to air containing C0 2 in concentrations of the same order of magnitude as the C0 2 concentration of air exhaled by a human being.
  • Indicator elements of this kind are known per se, see, for example, US-A-4728499, O89/07957 and O91/05252.
  • a major use of such indicator elements is to indicate the proper in ⁇ tubation.of a patient's trachea (windpipe).
  • This use relies on the fact that air exhaled by a human being contains C0 2 in much higher concentrations, 4 to 6 percent, than does the air in the oesophagus (gullet) , the C0 2 concentration of which is approximately equal to that of the atmospheric air and thus is only a few hundredths of one percent.
  • the air exhaled through the intubation tube such as a tracheal catheter, will have a relatively high concentration of C0 2 and will, therefore, cause a colour change of an indicator element of the above- mentioned kind which is located in the exhalation path, e.g. at the distal end of the intubation tube.
  • the indicator element should be located such that it is readily viewable from the outside, and if its response is sufficiently rapid, it will change colour immediately upon the first exhalation and, consequently, will immediately indicate that the intubation tube does in fact extend into the trachea as desired, and not into the oesophagus.
  • indicator element If the indicator element responds sufficiently rapidly, the colour change will reverse on each inhalation and occur again on each exhalation.
  • indicator elements which respond sufficiently rapidly to be able to follow the changes of the C0 2 concentration with inhalations and exhalations at the normal respiration rate, which is on the order of 10 breaths per minute.
  • the reason why the response time of the known indicator elements increases gradually may be that the balance of the amount of water bound to the indicator element against the desired response time is upset under the influence of the moisture contained in the exhaled air.
  • An object of the invention is to provide an indicating device of the kind mentioned above which is capable of indi ⁇ cating the presence of C0 2 in a patient's exhaled air over an extended period of time, namely such that a colour change of the C0 2 indicator element is brought about and reversed with each breath of the patient throughout the monitored period.
  • the construction of the indicating device according to the invention is based on the concept of providing for the C0 2 to operate in an environment which is of a character such that the amount of water in the indicator element, which amount has been selected or determined in connection with the preparation of the indicator element during its manufacture, remains substantially unchanged for a substantial period of time, such as 1 to 5 hours.
  • the indicator element is incorporated in a regenerative heat-moisture exchanger, namely at the section of the flow-through air passage thereof which in use is remote from the respiratory tract of the patient and separated from the respiratory tract by the moist-absorbing element of the heat-moisture exchanger.
  • the heat-moisture exchanger may be of a type which is known per se; several of the commercially available single- use heat-moisture exchangers can quite easily be modified and equipped with a C0 2 indicator element of the kind contempla ⁇ ted here.
  • its housing, or at least the part of the housing where the indicator element is located, should be transparent so that the indicator element can readily be viewed by a person who monitors the breathing of the patient.
  • the invention is illustrated in the accompanying drawing which shows an exemplary embodiment.
  • Fig. 1 is a diagrammatic view which shows the use of the device according to the invention
  • Fig. 2 is a side view of the device in Fig. 1, certain portions being shown in section;
  • Fig. 3 is a plan view of the device shown in Fig. 2 with certain portions of the housing of the device and the heat- moisture exchanger mounted inside the housing being broken away so that the indicator element can be seen.
  • Fig. 1 shows a patient with an inserted tracheal cathe ⁇ ter 11 the distal end of which is connected to a regenerative heat-moisture exchanger 12, inside the housing 13 of which a C0 2 indicator element 14 of the kind mentioned above is mounted.
  • the patient may be connected to a ventilator or an anaesthetic machine, which, however, is not shown in the drawing.
  • the heat-moisture exchanger 12 may be of any known design.
  • One side of the exchanger housing 13 is provided with a connecting port 15, hereinafter referred to as the wet connector, which is con ⁇ nected to the tracheal catheter 11.
  • the housing 13 has a similar connecting port 16, hereinafter re ⁇ ferred to as the dry connector, by which the housing is con- nected to the ventilator or anaesthetic machine through the intermediary of a conventional Y-piece 17.
  • the hous ⁇ ing has a further port which is used for measuring or moni- toring purposes.
  • the open space in the housing between the connectors 15 and 16 defines a flow-through passage P through which the air flows between the connectors when the patient breathes.
  • the main portion of the flow-through passage is occupied by a heat-moisture exchanger element (hygroscopic condenser/humi- difier) 18 of a kind well known per se, which is arranged such that the air is forced to flow through it when the pati ⁇ ent breathes.
  • the heat-moisture exchanger element 18 absorbs moisture from the exhaled air and thereby absorbs a large portion of the heat content of the air.
  • the inhaled air is humidified and heated in the exchanger element because it absorbs moisture and heat which has been given up to the exchanger element during the exha ⁇ lation.
  • the indicator element 14 is a rectangular sheet which is mounted in the housing 13 such that when the patient breathes, both when he inhales and when he exhales, the indicator element is contacted on both sides by the air at the side of the heat-moisture element 18 which is closest to the dry connector 16.
  • the indicator element 14 constantly operates in an environment of low and substantially constant moisture content. For that reason, the indicator element can operate for a comparatively long time without the moisture balance in it becoming substantially upset. It therefore is capable of responding rapidly to C0 2 concentrations above the value for which it has been set, and it is thus capable of undergoing a colour change upon each breath over a long period of time.
  • the indicator element 14 can be designed and arranged in many different ways within the scope of the invention.
  • the housing should therefore be transpa ⁇ rent at least at the side where the indicator element is located; suitably, the entire housing 13 or the housing por- tion 13A located opposite to the indicator element 14 con ⁇ sists of clear transparent plastic.
  • the indicator element 14 is adapted to the temperature and relative humidity of the environment in which it is expected to operate inside the heat-moisture exchanger during use of the indicating device, more particularly during exhalation.
  • the indicator element is therefore prepared during the manufacture thereof in a manner such that it operates optimally in the conditions which may be expected to exist at the dry connector 16 during the exha ⁇ lation.
  • the indicator element is sealed in the heat-moisture exchanger in such a manner, e.g. by enclosing the entire heat-moisture exchanger with the indicator element inserted therein in a moisture-tight enve- lope, that it is not affected by varying humidity of the environment until the seal is broken, normally immediately prior to the actual use.
  • the indicator element is therefore optimised for a certain range of relative humidity and a certain temperature range.
  • optimisation for the range of 20-45% relative humidity and a temperature range of 21-24°C is suitable and preferable.
  • Optimisation for the upper regions of these ranges characterises an embodiment intended primarily for use during anaesthesia, while an optimisation for the lower regions of the ranges charac ⁇ terises an embodiment which is intended primarily for use in intensive care.

Abstract

A device for indicating the presence of CO2 in a patient's inhaled air comprises a CO2 detector including an indicator element (14) which undergoes a reversible colour change in response to exposure thereof to air containing CO2 in concentrations of the same order of magnitude as the CO2 concentration of air exhaled by a human being, and also comprises a heat-moisture exchanger (12) including a housing (13) with a first connecting port (15) adapted to be connected to the trachea of a patient, and a second connecting port (15) adapted for connection to a ventilator or an anaesthetic machine, for example. In a flow-through passage (P) extending between the connecting ports (15, 16) there is mounted an element (18) for the regenerative exchange of heat and moisture between, on the one hand, air flowing through the flow-through passage (P) in one direction and, on the other hand, air flowing through the flow-through passage (P) in the opposite direction. The indicator element (14) is disposed in the flow-through passage on the side of the heat-moisture exchanger element (18) remote from the first connecting port (15) and is viewable from outside the housing, and its response time for the colour change is sufficiently short to enable it to change colour upon each breath.

Description

A device for indicating the presence of carbon dioxide in a patient's exhaled air
This invention relates to a device for indicating the presence of carbon dioxide, C02, in the air exhaled by a patient. More particularly, the invention relates to a device of the kind comprising an indicator element which undergoes a reversible change of colour in response to the exposure there¬ of to air containing C02 in concentrations of the same order of magnitude as the C02 concentration of air exhaled by a human being.
Indicator elements of this kind are known per se, see, for example, US-A-4728499, O89/07957 and O91/05252. A major use of such indicator elements is to indicate the proper in¬ tubation.of a patient's trachea (windpipe). This use relies on the fact that air exhaled by a human being contains C02 in much higher concentrations, 4 to 6 percent, than does the air in the oesophagus (gullet) , the C02 concentration of which is approximately equal to that of the atmospheric air and thus is only a few hundredths of one percent.
Thus, with proper intubation, the air exhaled through the intubation tube, such as a tracheal catheter, will have a relatively high concentration of C02 and will, therefore, cause a colour change of an indicator element of the above- mentioned kind which is located in the exhalation path, e.g. at the distal end of the intubation tube. For obvious rea¬ sons, the indicator element should be located such that it is readily viewable from the outside, and if its response is sufficiently rapid, it will change colour immediately upon the first exhalation and, consequently, will immediately indicate that the intubation tube does in fact extend into the trachea as desired, and not into the oesophagus. If the indicator element responds sufficiently rapidly, the colour change will reverse on each inhalation and occur again on each exhalation. Known in the art are indicator elements which respond sufficiently rapidly to be able to follow the changes of the C02 concentration with inhalations and exhalations at the normal respiration rate, which is on the order of 10 breaths per minute.
It has been found, however, that the response time in¬ creases gradually with the number of exhalations so that the indicator element will be unable to follow the changes after a number of exhalations have taken place. This increase of the response time causes no problem in the above-described use in which it is sufficient to detect that the intubation was successful, because, in principle, a single colour change suffices for that purpose. However, in cases in which it is desired to monitor the breathing in respect of the presence of C02 for a longer period, such as for an hour or a few hours, known indicator elements are not suitable. In such cases, therefore, it has been necessary to rely on other types of C02 detecting devices, primarily electrical instru¬ ments.
The reason why the response time of the known indicator elements increases gradually may be that the balance of the amount of water bound to the indicator element against the desired response time is upset under the influence of the moisture contained in the exhaled air.
An object of the invention is to provide an indicating device of the kind mentioned above which is capable of indi¬ cating the presence of C02 in a patient's exhaled air over an extended period of time, namely such that a colour change of the C02 indicator element is brought about and reversed with each breath of the patient throughout the monitored period.
This object is achieved with the construction of the indicating device which is set forth in the independent claim.
The construction of the indicating device according to the invention is based on the concept of providing for the C02 to operate in an environment which is of a character such that the amount of water in the indicator element, which amount has been selected or determined in connection with the preparation of the indicator element during its manufacture, remains substantially unchanged for a substantial period of time, such as 1 to 5 hours. According to the invention, the indicator element is incorporated in a regenerative heat-moisture exchanger, namely at the section of the flow-through air passage thereof which in use is remote from the respiratory tract of the patient and separated from the respiratory tract by the moist-absorbing element of the heat-moisture exchanger.
The heat-moisture exchanger may be of a type which is known per se; several of the commercially available single- use heat-moisture exchangers can quite easily be modified and equipped with a C02 indicator element of the kind contempla¬ ted here. Naturally, its housing, or at least the part of the housing where the indicator element is located, should be transparent so that the indicator element can readily be viewed by a person who monitors the breathing of the patient. The invention is illustrated in the accompanying drawing which shows an exemplary embodiment.
Fig. 1 is a diagrammatic view which shows the use of the device according to the invention;
Fig. 2 is a side view of the device in Fig. 1, certain portions being shown in section;
Fig. 3 is a plan view of the device shown in Fig. 2 with certain portions of the housing of the device and the heat- moisture exchanger mounted inside the housing being broken away so that the indicator element can be seen. Fig. 1 shows a patient with an inserted tracheal cathe¬ ter 11 the distal end of which is connected to a regenerative heat-moisture exchanger 12, inside the housing 13 of which a C02 indicator element 14 of the kind mentioned above is mounted. The patient may be connected to a ventilator or an anaesthetic machine, which, however, is not shown in the drawing.
Apart from the indicator element 14, the heat-moisture exchanger 12 may be of any known design. One side of the exchanger housing 13 is provided with a connecting port 15, hereinafter referred to as the wet connector, which is con¬ nected to the tracheal catheter 11. On the opposite side, the housing 13 has a similar connecting port 16, hereinafter re¬ ferred to as the dry connector, by which the housing is con- nected to the ventilator or anaesthetic machine through the intermediary of a conventional Y-piece 17. On the side of the housing 13 where the dry connector 16 is provided, the hous¬ ing has a further port which is used for measuring or moni- toring purposes.
The open space in the housing between the connectors 15 and 16 defines a flow-through passage P through which the air flows between the connectors when the patient breathes. The main portion of the flow-through passage is occupied by a heat-moisture exchanger element (hygroscopic condenser/humi- difier) 18 of a kind well known per se, which is arranged such that the air is forced to flow through it when the pati¬ ent breathes. Upon exhalation, the heat-moisture exchanger element 18 absorbs moisture from the exhaled air and thereby absorbs a large portion of the heat content of the air. Upon inhalation, the inhaled air is humidified and heated in the exchanger element because it absorbs moisture and heat which has been given up to the exchanger element during the exha¬ lation. In the illustrated example, the indicator element 14 is a rectangular sheet which is mounted in the housing 13 such that when the patient breathes, both when he inhales and when he exhales, the indicator element is contacted on both sides by the air at the side of the heat-moisture element 18 which is closest to the dry connector 16.
Because the exhaled air is relatively dry when it con¬ tacts the indicator element 14 after having given up most of its moisture content to the heat-moisture exchanger element 18 and because the inhaled air is also relatively dry before it enters the heat-moisture exchanger element, the indicator element 14 constantly operates in an environment of low and substantially constant moisture content. For that reason, the indicator element can operate for a comparatively long time without the moisture balance in it becoming substantially upset. It therefore is capable of responding rapidly to C02 concentrations above the value for which it has been set, and it is thus capable of undergoing a colour change upon each breath over a long period of time. The indicator element 14 can be designed and arranged in many different ways within the scope of the invention. Natu¬ rally, it should be arranged such that it is effectively con¬ tacted by the flowing air during both the inhalation and the exhalation. Obviously, it is important that it can be viewed from outside the housing 13 so that the colour changes can be observed visually. The housing should therefore be transpa¬ rent at least at the side where the indicator element is located; suitably, the entire housing 13 or the housing por- tion 13A located opposite to the indicator element 14 con¬ sists of clear transparent plastic.
Preferably, the indicator element 14 is adapted to the temperature and relative humidity of the environment in which it is expected to operate inside the heat-moisture exchanger during use of the indicating device, more particularly during exhalation.
In a preferred embodiment, the indicator element is therefore prepared during the manufacture thereof in a manner such that it operates optimally in the conditions which may be expected to exist at the dry connector 16 during the exha¬ lation. Following such preparation, the indicator element is sealed in the heat-moisture exchanger in such a manner, e.g. by enclosing the entire heat-moisture exchanger with the indicator element inserted therein in a moisture-tight enve- lope, that it is not affected by varying humidity of the environment until the seal is broken, normally immediately prior to the actual use.
In one embodiment, the indicator element is therefore optimised for a certain range of relative humidity and a certain temperature range. Generally, optimisation for the range of 20-45% relative humidity and a temperature range of 21-24°C is suitable and preferable. Optimisation for the upper regions of these ranges characterises an embodiment intended primarily for use during anaesthesia, while an optimisation for the lower regions of the ranges charac¬ terises an embodiment which is intended primarily for use in intensive care.

Claims

Claims
1. A device for indicating the presence of C02 in a patient's exhaled air, which device comprises a C02 detector including an indicator element which undergoes a reversible colour change in response to exposure thereof to air contai¬ ning C02 in concentrations of the same order of magnitude as the C02 concentration of air exhaled by a human being, characterised by a heat-moisture exchanger (12) comprising a housing (13) which includes a first connecting port (15) adapted to be connected to the trachea of a patient and a second connecting port (16) adapted to be connected to a ven¬ tilator or an anaesthesia machine, for example, and which has mounted in a flow-through passage (P) extending between the connecting ports (15, 16) an exchanger element (18) for the regenerative exchange of heat and moisture between on the one hand, air which flows through the flow-through passage (P) in one direction and, on the other hand, air which flows through the flow-through passage (P) in the opposite direction, the indicator element (14) being disposed in the flow-through passage on the side of the heat-moisture exchanger element (18) remote from the first connection port (15) and viewable from outside the housing, and the indicator element (14) having a response time for colour changes which is suffi¬ ciently short to enable the indicator element to change colour upon each breath.
2. A device according to claim 1, characterised in that the indicator element (14) is viewable through a transparent section of a wall of the housing (13) .
PCT/SE1993/000554 1992-06-29 1993-06-22 A device for indicating the presence of carbon dioxide in a patient's exhaled air WO1994000756A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP93915065A EP0601171B1 (en) 1992-06-29 1993-06-22 A device for indicating the presence of carbon dioxide in a patient's exhaled air
US08/190,189 US5468451A (en) 1992-06-29 1993-06-22 Device for indicating the presence of carbon dioxide in a patient's exhaled air
DE69313984T DE69313984T2 (en) 1992-06-29 1993-06-22 DEVICE FOR DISPLAYING THE PRESENCE OF CARBON DIOXIDE IN A PATIENT'S EXHAUST AIR
JP6502261A JPH06510690A (en) 1992-06-29 1993-06-22 A device for indicating the presence of carbon dioxide in the air exhaled by a patient

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9201995-9 1992-06-29
SE9201995A SE505709C2 (en) 1992-06-29 1992-06-29 Device for indicating the presence of carbon dioxide in a patient's exhaled air

Publications (1)

Publication Number Publication Date
WO1994000756A1 true WO1994000756A1 (en) 1994-01-06

Family

ID=20386638

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE1993/000554 WO1994000756A1 (en) 1992-06-29 1993-06-22 A device for indicating the presence of carbon dioxide in a patient's exhaled air

Country Status (9)

Country Link
US (1) US5468451A (en)
EP (1) EP0601171B1 (en)
JP (1) JPH06510690A (en)
AT (1) ATE158413T1 (en)
DE (1) DE69313984T2 (en)
DK (1) DK0601171T3 (en)
ES (1) ES2109505T3 (en)
SE (1) SE505709C2 (en)
WO (1) WO1994000756A1 (en)

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DE69313984D1 (en) 1997-10-23
EP0601171A1 (en) 1994-06-15
JPH06510690A (en) 1994-12-01
ES2109505T3 (en) 1998-01-16
ATE158413T1 (en) 1997-10-15
SE9201995L (en) 1993-12-30
DE69313984T2 (en) 1998-04-09
SE9201995D0 (en) 1992-06-29
EP0601171B1 (en) 1997-09-17
DK0601171T3 (en) 1998-05-04
US5468451A (en) 1995-11-21
SE505709C2 (en) 1997-09-29

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