WO1994004675A3 - Dna sequence encoding a novel member of the steroid and thyroid hormone receptor family - Google Patents

Dna sequence encoding a novel member of the steroid and thyroid hormone receptor family Download PDF

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Publication number
WO1994004675A3
WO1994004675A3 PCT/EP1993/002223 EP9302223W WO9404675A3 WO 1994004675 A3 WO1994004675 A3 WO 1994004675A3 EP 9302223 W EP9302223 W EP 9302223W WO 9404675 A3 WO9404675 A3 WO 9404675A3
Authority
WO
WIPO (PCT)
Prior art keywords
steroid
hormone receptor
sequence encoding
dna sequence
thyroid hormone
Prior art date
Application number
PCT/EP1993/002223
Other languages
French (fr)
Other versions
WO1994004675A2 (en
Inventor
Richard Kroczek
Hans-Werner Mages
Original Assignee
Richard Kroczek
Mages Hans Werner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richard Kroczek, Mages Hans Werner filed Critical Richard Kroczek
Priority to AU49503/93A priority Critical patent/AU4950393A/en
Publication of WO1994004675A2 publication Critical patent/WO1994004675A2/en
Publication of WO1994004675A3 publication Critical patent/WO1994004675A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743—Steroid hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The invention provides a DNA sequence encoding a novel member of the steroid and thyroid hormone receptor family. The invention also relates to the isolation of said sequence and the expression of the encoded protein and chimeric proteins comprising all or part of the DNA or ligand-binding region of said hormone receptor. The invention furthermore provides antibodies directed to said proteins and diagnostic and therapeutic compositions for the diagnosis and therapy of steroid receptor-related diseases.
PCT/EP1993/002223 1992-08-19 1993-08-19 Dna sequence encoding a novel member of the steroid and thyroid hormone receptor family WO1994004675A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU49503/93A AU4950393A (en) 1992-08-19 1993-08-19 Dna sequence encoding a novel member of the steroid and thyroid hormone receptor family

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP92114134.7 1992-08-19
EP92114134 1992-08-19

Publications (2)

Publication Number Publication Date
WO1994004675A2 WO1994004675A2 (en) 1994-03-03
WO1994004675A3 true WO1994004675A3 (en) 1994-12-08

Family

ID=8209924

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1993/002223 WO1994004675A2 (en) 1992-08-19 1993-08-19 Dna sequence encoding a novel member of the steroid and thyroid hormone receptor family

Country Status (2)

Country Link
AU (1) AU4950393A (en)
WO (1) WO1994004675A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6537773B1 (en) * 1995-06-07 2003-03-25 The Institute For Genomic Research Nucleotide sequence of the mycoplasma genitalium genome, fragments thereof, and uses thereof
US7544511B2 (en) 1996-09-25 2009-06-09 Neuralstem Biopharmaceuticals Ltd. Stable neural stem cell line methods
US6284539B1 (en) 1998-10-09 2001-09-04 Neuralstem Biopharmaceuticals, Ltd. Method for generating dopaminergic cells derived from neural precursors
US6312949B1 (en) * 1999-03-26 2001-11-06 The Salk Institute For Biological Studies Regulation of tyrosine hydroxylase expression
GB9913863D0 (en) * 1999-06-15 1999-08-11 Smithkline Beecham Plc Novel compounds
GB0006864D0 (en) * 2000-03-21 2000-05-10 Smithkline Beecham Plc New use
US8293488B2 (en) 2002-12-09 2012-10-23 Neuralstem, Inc. Method for screening neurogenic agents
WO2004053071A2 (en) 2002-12-09 2004-06-24 Judith Kelleher-Andersson Method for discovering neurogenic agents
KR101505347B1 (en) 2004-11-17 2015-03-23 뉴럴스템, 인크. Transplantation of Human Neural Cells for Treatment of Neurodegenerative Conditions
KR101765980B1 (en) 2010-07-28 2017-08-07 뉴럴스템, 인크. Methods for treating and/or reversing neurodegenerative diseases and/or disorders
EP3209306B1 (en) 2014-10-20 2024-04-24 Neuralstem, Inc. Stable neural stem cells comprising an exogenous polynucleotide coding for a growth factor and methods of use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990007517A1 (en) * 1988-12-23 1990-07-12 The Salk Institute For Biological Studies Receptor transcription-repression activity compositions and methods

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990007517A1 (en) * 1988-12-23 1990-07-12 The Salk Institute For Biological Studies Receptor transcription-repression activity compositions and methods

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
O. RILKE ET AL.: "Further characterization of a novel steroid receptor in T-cells.", IMMUNOBIOLOGY, vol. 186, no. 1-2, October 1992 (1992-10-01), STUTTGART, GERMANY, pages 166 *
R. KROCZEK ET AL.: "Identification and initial characterization of a novel steroid receptor involved in early T-cell activation.", IMMUNOBIOLOGY, vol. 183, no. 3-4, October 1991 (1991-10-01), STUTTGART, GERMANY, pages 284 *
R. KROCZEK ET AL.: "Identification and initial characterization of a novel steroid receptor involved in early T-cell activation.", JOURNAL OF LEUKOCYTE BIOLOGY, vol. SUPPL. 2, 1991, NEW YORK, USA, pages 70 *
S. LAW ET AL.: "Identification of a new brain-specific transcription factor, NURR1.", MOLECULAR ENDOCRINOLOGY, vol. 6, no. 12, December 1992 (1992-12-01), BALTIMORE MD, USA, pages 2129 - 2135, XP002945683, DOI: doi:10.1210/me.6.12.2129 *

Also Published As

Publication number Publication date
WO1994004675A2 (en) 1994-03-03
AU4950393A (en) 1994-03-15

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