WO1994009752A1 - Antibacterial mouthwash - Google Patents
Antibacterial mouthwash Download PDFInfo
- Publication number
- WO1994009752A1 WO1994009752A1 PCT/US1993/010329 US9310329W WO9409752A1 WO 1994009752 A1 WO1994009752 A1 WO 1994009752A1 US 9310329 W US9310329 W US 9310329W WO 9409752 A1 WO9409752 A1 WO 9409752A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- weight
- composition according
- oral hygiene
- hygiene composition
- oral
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
Definitions
- This invention relates to an antibacterial oral hygiene composition. More specifically, this invention relates to an antibacterial oral hygiene composition which is alcohol-free and which possesses improved antibacterial activity against oral microorganisms.
- Mouthwashes are liquid preparations specifically designed to cleanse and refresh the mouth. While many early mouthwashes comprised no more than pleasantly flavored colored solutions, a new generation of rinses are provided with active ingredients which have efficacious action against problems associated with malodor, dental caries, and gum diseases.
- Dental caries teeth decay are one of the most common afflictions known to human.
- the causation of dental caries is complex and includes several factors.
- the exposed surfaces of teeth develop a deposit of salivary proteins, food debris and bacteria, the combination of which is called dental plaque.
- Streptococcus m ⁇ tans the principle etiological organism responsible for dental caries, converts dietary sugar into organic acids. These acids release hydrogen ions in the subsurface layers of enamel, creating an acidic environment. When exposed to acid, enamel loses calcium and phosphate ions and these ions can diffuse out of the enamel. If such mineral loss continues, cavities can develop.
- Gum diseases are caused by pathogenic oral microorganisms, the early sign of which is generally termed as gingivitis. Gingivitis is accompanied by the inflammations and/or bleeding of gums. Antibacterial mouthwashes may be effective in inhibiting microorganisms found in the mouth, thus preventing caries and ameliorating infectious conditions. In many instances these microorganisms are responsible directly or indirectly for malodor.
- antibacterial agents employed in mouthwashes include phenolic compounds such as S-naphthol, thymol, chlorothymol, amyl-, hexyl-, heptyl- and octylphenol, hexylresorcinol, hexachlorophene, and phenol; quaternary ammonium compounds such as quaternary morpholinium alky!
- miscellaneous antibacterial compounds such as benzoic acid, formaldehyde, potassium chlorate, tyrothricin, gramicidin, iodine, sodium perborate, and urea peroxide.
- miscellaneous antibacterial compounds such as benzoic acid, formaldehyde, potassium chlorate, tyrothricin, gramicidin, iodine, sodium perborate, and urea peroxide.
- miscellaneous antibacterial compounds such as benzoic acid, formaldehyde, potassium chlorate, tyrothricin, gramicidin, iodine, sodium perborate, and urea peroxide.
- many of these compounds have a disagreeable taste, or are only antibacterially effective at levels where they are considered unsafe for human use.
- an antibacterial oral hygiene composition comprising:
- the present invention provides the above-defined oral hygiene composition wherein no alcohol is included.
- the present invention provides a method of inhibiting oral microor ⁇ ganisms comprising contacting the tissue of oral cavity or teeth with the above- defined oral hygiene composition for a sufficient time to reduce the microorganisms.
- the present invention provides a method of controlling malodor in the mouth comprising contacting the tissue of oral cavity or teeth with the above- defined oral hygiene composition for a sufficient time to reduce the malodor.
- compositions of the present invention are physiologically acceptable in that they are safe and organoleptically tolerable in the oral cavity and have no significant side effects either orally or systemically when used as directed.
- Sodium benzoate is widely used as a preservative in pharmaceuticals and food products. It has been surprisingly found that sodium benzoate is effective for inhibiting oral microorganisms in the formulations described above.
- An effective concentration range for sodium benzoate in the compositions of the present invention is generally from about 0.05% to about 0.2% by weight of the total with the most effective level being about 0.1%..
- suitable weak carboxylic acids include citric acid, tartaric acid (D, l_ Dl_ or a mixture thereof), acetic acid, and benzoic acid.
- the most preferred carboxylic acid is citric acid.
- the carboxylic acid primarily serve as an acidula ⁇ t but contributes to the antibacterial activity of the composition in a synergistic manner.
- this carboxylic acid should be present in the composition at a concentration of from 0.01% to about 1.0% by weight of the total with the most desired level being about
- Buffering agents adjust the pH of the final formulation.
- the buffering agent should be capable of bringing the pH to a physiologically acceptable level of between about 3.0 and 8.0, more preferably between 6.3 and 6.7.
- Exemplary buffering agents are an alkali metal or alkaline earth metal salt, and an ami ⁇ e (e.g., ammonium) salt of the weak carboxylic acid.
- the preferred buffering agents are sodium citrate, potassium citrate, and sodium acetate.
- the buffering agent should be present in the composition at a concentration of from about 2.0% to about 5.0% by weight of the total with the most desired level being about 3.5%.
- Surfactants may be included in the composition to keep the composition clear and to prevent from its becoming turbid.
- the surfactants are known to solubilize flavoring agents and other ingredients in a mouthwash formulation. Any food grade surfactants can be employed and are ascertainable to one skilled in the art.
- a particularly suitable surfactant is an alkyl sulfate anionic surfactant. Examples of the alkyl sulfate surfactants are sodium lauryl sulfate (i.e., sodium dodecyl sulfate), and sodium tetradecyl sulfate. Other salts (e.g., potassium, magnesium, and ammonium) of the foregoing alkyl sulfates can also be used.
- the surfactants is present in the composition at a concentration of from about 0.25% to about 1.5% by weight of the total with the most desired level being about 0.75%.
- Sweetening agents may be included in the composition to sweeten the taste of the composition. While sodium saccharin is the preferred sweetening agent, any food- use approved natural or artificial sweeteners are contemplated within the scope of the present invention. These sweeteners are, for example, sorbitol, xyl ' rtol, asparatame, and sucrose. Preferably, sodium saccharin is present in the composition at a concentration of from 0% to about 0.2% by weight of the total with the most desired level being about 0.15%. When employing a sweetening agent other than sodium saccharin, any amount required to producing an equivalent level of sweetening to the 0% to about 0.2% sodium saccharin will suffice. Additionally, any mixture of sweetening agents having an equivalent sweetening effect and compatible to the formulation is contemplated within the term of sweetening agents.
- Flavoring agents may be included in the composition.
- the flavoring agent is present in the composition at a concentration of from 0% to about 2.0% by weight of the total. More preferably, the concentration should be of from about 0.05% to about 2.0% with the most desired level being about 0.25%.
- the flavoring agents can be selected from cinnamon, cassia, anise, menthol, methyl salicylate, peppermint oil, spearmint oil, and other known flavor modifiers. Particularly preferred are peppermint spearmint oil (both natural and synthetic analog), and a mixture of the two.
- Water should be included in the composition to serve as a fluid base of the composition and to function as a flushing medium to wash away food debris from the mouth.
- the composition of the present invention contains no alcohol.
- Etha ⁇ ol is normally included in prior art mouthwashes in order to impart brte and refreshness to the mouthwash.
- the alcohol may, in some instances, act to enhance the solubilization of certain flavor oils, and may enhance the cleansing efficacy. However, it has been found that more than adequate antibacterial activity can be achieved and the formulation can remain water-clear without the inclusion of the alcohol in the composition.
- compositions of the present invention may contain humectants, emulsifiers, colorants and preservatives.
- humectants emulsifiers
- colorants emulsifiers
- preservatives emulsifiers
- the incorporation of these agents into the composition is not critical and where a benefit is seen, their incorporation is recommended.
- composition of the present invention is a clear, stable, physiologically acceptable, and is found to produce microorganisms inhibition in the mouth at least equivalent to the degree of inhibition brought about by commercially available mouthwashes containing alcohol. The composition remains clear without the formation of turbidity or precipitation for a prolonged period of storage at elevated or reduced tempera ⁇ tures.
- the composition of the invention is effective for controlling malodor in the mouth associated with the ingestion of foods such as garlic and onion.
- a sufficient amount of the composition is allowed to contact with the tissue of oral cavity or teeth for a period sufficient to reduce the microorganism population in the mouth or the malodor.
- a contact time of less than about 15 seconds is sufficient Prolonged contact time will increase the effects, and it is preferred that the contact time be about 30 seconds.
- This example describes an experiment which was done to evaluate the inhibitory effect of different mouth rinse compositions on various oral microorganisms.
- the organisms which were tested were Streptococcus salivarius, Bacteroides sp.,
- Lactobaciilus salivarius Lactobaciilus salivarius, and Candida albicans.
- S. salivarius was cultured in yeast-glucose broth, and L salivarius was cultured in brain-heart infusion broth. Assays were performed on blood-auger plates for S. salivarius and brain-heart infusion agar for L salivarius.
- the Bacteroides sp. was cultured in yeast-glucose broth and assayed on Wilkins-Chalgren anaerobic agar.
- the Bacteroides sp. was incubated anaerobicaily at 37" C in a BDL GasPak Anaerobic System (Becton Dickinson Microbiology Systems, Cockeysville, MD). For all organisms, sterile paper discs (6.5 mm in diameter) were soaked with the materials to be tested, then blotted to remove any excess mouth rinse. The bacteria were swabbed over the surface of the agar plates in two directions, and the prepared discs were placed on the Petri dishes with a sterile forceps along with a control antibiotic disc (penicillin G/2 units, Difco, Detroit, MI). The S. salivarius plate was incubated at 37 ⁇ C in 10% C0 2 . After 48 hours, all of the plates were evaluated and the diameter of the zones of microbial inhibition were measured in millimeters using a caliper. The results obtained are shown in Table 1.
- composition of the invention (Rembrandt) was able to inhibit ail three strains of bacteria at levels comparable to the best of the alcohol-containing mouth rinses (Listerine).
- composition of the Invention showed ' significantly larger zones of inhibition than any of the other non-alcohol compositions which were tested. None of the compositions inhibitied C. albicans.
Abstract
Description
Claims
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019950701279A KR100296414B1 (en) | 1992-10-28 | 1993-10-26 | Antibacterial Mouthwash |
PL93308359A PL173704B1 (en) | 1992-10-28 | 1993-10-26 | Bactericidal mouth wash |
BR9307332A BR9307332A (en) | 1992-10-28 | 1993-10-26 | Antibacterial mouthwash |
JP51129994A JP3756945B2 (en) | 1992-10-28 | 1993-10-26 | Antibacterial mouthwash |
AU54538/94A AU5453894A (en) | 1992-10-28 | 1993-10-26 | Antibacterial mouthwash |
AT93925093T ATE275927T1 (en) | 1992-10-28 | 1993-10-26 | ANTIBACTERIAL MOUTHWASH |
DE69333625T DE69333625T2 (en) | 1992-10-28 | 1993-10-26 | ANTIBACTERIAL MOUTHWATER |
CA002146330A CA2146330C (en) | 1992-10-28 | 1993-10-26 | Antibacterial mouthwash |
EP93925093A EP0666731B1 (en) | 1992-10-28 | 1993-10-26 | Antibacterial mouthwash |
DK93925093T DK0666731T3 (en) | 1992-10-28 | 1993-10-26 | Antibacterial mouthwash |
NO951239A NO308393B1 (en) | 1992-10-28 | 1995-03-30 | Antibacterial oral hygiene preparation |
DK038095A DK38095A (en) | 1992-10-28 | 1995-04-04 | Antibacterial mouthwash |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US96776892A | 1992-10-28 | 1992-10-28 | |
US967,768 | 1992-10-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1994009752A1 true WO1994009752A1 (en) | 1994-05-11 |
Family
ID=25513286
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1993/010329 WO1994009752A1 (en) | 1992-10-28 | 1993-10-26 | Antibacterial mouthwash |
Country Status (18)
Country | Link |
---|---|
US (1) | US5707610A (en) |
EP (1) | EP0666731B1 (en) |
JP (1) | JP3756945B2 (en) |
KR (1) | KR100296414B1 (en) |
AT (1) | ATE275927T1 (en) |
AU (2) | AU5453894A (en) |
BR (1) | BR9307332A (en) |
CA (1) | CA2146330C (en) |
DE (1) | DE69333625T2 (en) |
DK (2) | DK0666731T3 (en) |
ES (1) | ES2227520T3 (en) |
GE (1) | GEP20002228B (en) |
NO (1) | NO308393B1 (en) |
NZ (1) | NZ257765A (en) |
PL (1) | PL173704B1 (en) |
PT (1) | PT666731E (en) |
RU (1) | RU2125440C1 (en) |
WO (1) | WO1994009752A1 (en) |
Cited By (1)
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GB2374285A (en) * | 2001-03-05 | 2002-10-16 | Gc Kk | A solubilizing agent of carbonated calcium hydroxide-based root canal filler comprising an acid and a sterilizing agent |
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CA2143037C (en) * | 1994-05-02 | 2002-04-30 | Atma Chaudhari | Alcohol free mouthwash |
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US6638175B2 (en) * | 1999-05-12 | 2003-10-28 | Callaway Golf Company | Diagnostic golf club system |
WO2000076556A2 (en) * | 1999-06-11 | 2000-12-21 | Neorx Corporation | High dose radionuclide complexes for bone marrow suppression |
US7094885B2 (en) * | 1999-07-11 | 2006-08-22 | Neorx Corporation | Skeletal-targeted radiation to treat bone-associated pathologies |
US6927197B1 (en) * | 1999-11-08 | 2005-08-09 | Water Journey Ltd. | Antibacterial compositions and method of using same |
JP2004536034A (en) * | 2001-01-08 | 2004-12-02 | ネオルクス コーポレイション | Therapeutic and diagnostic compounds, compositions and methods |
US6610276B2 (en) * | 2001-01-12 | 2003-08-26 | Steven A. Melman | Multi-functional dental composition |
US7045116B2 (en) | 2001-12-13 | 2006-05-16 | Dow Global Technologies Inc. | Treatment of osteomyelitis with radiopharmaceuticals |
CN102266272B (en) | 2002-11-27 | 2012-12-26 | Dmi生物科学公司 | Personal care composition and products |
AU2004275821A1 (en) * | 2003-09-25 | 2005-04-07 | Dmi Biosciences Inc. | Methods and products which utilize N-acyl-L-aspartic acid |
US20090232748A1 (en) * | 2003-11-07 | 2009-09-17 | Viratox, L.L.C. | Virucidal activities of cetylpyridinium chloride |
US20050170013A1 (en) * | 2004-02-04 | 2005-08-04 | Douglas Jerry A. | Composition for treating a dermatological inflammatory response and method of preparation thereof |
JP2007153841A (en) * | 2005-12-07 | 2007-06-21 | Wakoudou Kk | Oral composition |
WO2008103416A1 (en) * | 2007-02-21 | 2008-08-28 | Capps Charles L | Synergistic enhancement of calcium propionate |
US20120003162A1 (en) | 2010-06-30 | 2012-01-05 | Mcneil-Ppc, Inc. | Methods of Preparing Non-Alcohol Bioactive Esential Oil Mouth Rinses |
US9084902B2 (en) | 2010-06-30 | 2015-07-21 | Mcneil-Ppc, Inc. | Non-alchohol bioactive essential oil mouth rinses |
EA201001053A1 (en) * | 2010-07-08 | 2011-10-31 | Общество С Ограниченной Ответственностью "Вдс" | COMPOSITION FOR PREVENTION OF CANDIDOSIS |
WO2012018519A1 (en) * | 2010-08-03 | 2012-02-09 | Isp Investments Inc. | An alcohol-free slightly-alcoholic oral care composition and a process for preparing same |
EP2637630A1 (en) * | 2010-11-12 | 2013-09-18 | Colgate-Palmolive Company | Oral care product and methods of use and manufacture thereof |
WO2012075257A2 (en) * | 2010-12-01 | 2012-06-07 | The University Of Georgia Research Foundation, Inc. | Compositions for oral and nasal hygiene |
NO339503B1 (en) * | 2014-06-18 | 2016-12-19 | Meda Otc Ab | Composition for the prevention or treatment of dental erosion |
RU2572705C1 (en) * | 2014-11-25 | 2016-01-20 | Татьяна Георгиевна Неустроева | Mouthwash composition |
US10524993B2 (en) | 2015-11-19 | 2020-01-07 | Fantarella & Harewood, Llc | Mouthwash composition |
HUE057646T2 (en) * | 2017-07-20 | 2022-05-28 | Thomas Leibbrand | Tyrothricin for use in the treatment or prophylaxis of body odour and preparations therefor |
CA3232245A1 (en) * | 2021-10-08 | 2023-04-13 | Inolex Investment Corporation | Biobased polyglyceryl esters and compositions comprising the same |
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-
1993
- 1993-10-26 WO PCT/US1993/010329 patent/WO1994009752A1/en active IP Right Grant
- 1993-10-26 RU RU95114536A patent/RU2125440C1/en not_active IP Right Cessation
- 1993-10-26 KR KR1019950701279A patent/KR100296414B1/en not_active IP Right Cessation
- 1993-10-26 CA CA002146330A patent/CA2146330C/en not_active Expired - Fee Related
- 1993-10-26 NZ NZ257765A patent/NZ257765A/en not_active IP Right Cessation
- 1993-10-26 ES ES93925093T patent/ES2227520T3/en not_active Expired - Lifetime
- 1993-10-26 BR BR9307332A patent/BR9307332A/en not_active IP Right Cessation
- 1993-10-26 GE GEAP19932580A patent/GEP20002228B/en unknown
- 1993-10-26 DE DE69333625T patent/DE69333625T2/en not_active Expired - Fee Related
- 1993-10-26 JP JP51129994A patent/JP3756945B2/en not_active Expired - Fee Related
- 1993-10-26 AT AT93925093T patent/ATE275927T1/en not_active IP Right Cessation
- 1993-10-26 DK DK93925093T patent/DK0666731T3/en active
- 1993-10-26 EP EP93925093A patent/EP0666731B1/en not_active Expired - Lifetime
- 1993-10-26 AU AU54538/94A patent/AU5453894A/en not_active Abandoned
- 1993-10-26 PT PT93925093T patent/PT666731E/en unknown
- 1993-10-26 PL PL93308359A patent/PL173704B1/en not_active IP Right Cessation
-
1995
- 1995-03-30 NO NO951239A patent/NO308393B1/en unknown
- 1995-04-04 DK DK038095A patent/DK38095A/en not_active Application Discontinuation
- 1995-05-30 US US08/453,484 patent/US5707610A/en not_active Expired - Lifetime
-
1998
- 1998-02-23 AU AU56263/98A patent/AU702781B2/en not_active Ceased
Patent Citations (15)
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US5211940A (en) * | 1991-06-21 | 1993-05-18 | Lion Corporation | Transparent liquid oral composition |
US5213790A (en) * | 1991-10-23 | 1993-05-25 | The Procter & Gamble Co. | Methods of reducing plaque and gingivitis with reduced staining |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2374285A (en) * | 2001-03-05 | 2002-10-16 | Gc Kk | A solubilizing agent of carbonated calcium hydroxide-based root canal filler comprising an acid and a sterilizing agent |
US6585514B2 (en) | 2001-03-05 | 2003-07-01 | Gc Corporation | Solubilizing agent of carbonated calcium hydroxide-based root canal filler and solubilizing method |
GB2374285B (en) * | 2001-03-05 | 2005-05-04 | Gc Kk | Use of solubilizing agent for solubilizing carbonated calcium hydroxide-based root canal filler |
Also Published As
Publication number | Publication date |
---|---|
PL308359A1 (en) | 1995-07-24 |
NZ257765A (en) | 1996-09-25 |
JPH08502970A (en) | 1996-04-02 |
CA2146330C (en) | 2000-04-25 |
RU95114536A (en) | 1997-02-27 |
DK0666731T3 (en) | 2004-10-18 |
PL173704B1 (en) | 1998-04-30 |
NO308393B1 (en) | 2000-09-11 |
EP0666731A4 (en) | 1997-03-05 |
ATE275927T1 (en) | 2004-10-15 |
AU702781B2 (en) | 1999-03-04 |
DE69333625D1 (en) | 2004-10-21 |
NO951239D0 (en) | 1995-03-30 |
JP3756945B2 (en) | 2006-03-22 |
GEP20002228B (en) | 2000-09-25 |
AU5626398A (en) | 1998-05-07 |
US5707610A (en) | 1998-01-13 |
EP0666731A1 (en) | 1995-08-16 |
DK38095A (en) | 1995-04-25 |
ES2227520T3 (en) | 2005-04-01 |
AU5453894A (en) | 1994-05-24 |
PT666731E (en) | 2004-11-30 |
DE69333625T2 (en) | 2005-09-22 |
KR100296414B1 (en) | 2001-10-24 |
NO951239L (en) | 1995-04-27 |
RU2125440C1 (en) | 1999-01-27 |
BR9307332A (en) | 1999-06-01 |
KR950703322A (en) | 1995-09-20 |
EP0666731B1 (en) | 2004-09-15 |
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