WO1994009755A1 - Method and composition for prevention and/or treatment of dandruff and seborrhoeic dermatitis - Google Patents

Method and composition for prevention and/or treatment of dandruff and seborrhoeic dermatitis Download PDF

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Publication number
WO1994009755A1
WO1994009755A1 PCT/EP1993/003060 EP9303060W WO9409755A1 WO 1994009755 A1 WO1994009755 A1 WO 1994009755A1 EP 9303060 W EP9303060 W EP 9303060W WO 9409755 A1 WO9409755 A1 WO 9409755A1
Authority
WO
WIPO (PCT)
Prior art keywords
propylene glycol
dandruff
concentration
scalp
composition
Prior art date
Application number
PCT/EP1993/003060
Other languages
French (fr)
Inventor
Michael Potts
Original Assignee
Beiersdorf Ag
Surtech International Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf Ag, Surtech International Limited filed Critical Beiersdorf Ag
Priority to EP93924089A priority Critical patent/EP0666734A1/en
Publication of WO1994009755A1 publication Critical patent/WO1994009755A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/006—Antidandruff preparations

Definitions

  • This invention relates to a method and composition for the prevention and/or treatment of scaling conditions of the scalp, such as dandruff, seborrhoeic dermatitis and psoriasis.
  • Previously known methods for preventing and treating dandruff generally involve applying to the scalp various anti-dandruff agents contained in lotions, gels and shampoos.
  • anti-dandruff agents include sulphur and selenium compounds, zinc pyrrithione and bacteriostatic and bacteriacidal agents such as, for example, hexachlorophene.
  • the use of such anti-dandruff agents can give rise to adverse reactions, for example allergic reactions and erythematous lesions. Consequently, known anti-dandruff agents cannot be used in the long term and it is frequently found that dandruff symptoms recur.
  • Known anti-dandruff agents are often difficult to formulate into cosmetically acceptable compositions .
  • UK Patent No. GB 2,205,743 described the finding that propylene glycol is effective as an anti-dandruff agent and that a significant anti-dandruff effect may be observed following application of propylene glycol to the scalp, e.g. in the form of a lotion, gel or shampoo.
  • Propylene glycol when used in accordance with the teachings of GB 2,205.743. avoided undesirable side effects which occur
  • Propylene glycol has hitherto also been described for use as a diluent, thinning agent or vehicle for various pharmaceutical products including such products intended for topical use.
  • carboxylic acid derivatives as active ingredients for treating keratinization defects.
  • DE-A-2,758,484 describes the use of chenodesoxic acid as the active ingredient of anti-dandruff compositions including lotions, gels and shampoos.
  • This specification mentions propylene glycol as an ingredient of such compositions but not as an active ingredient.
  • compositions containing as active ingredient, inter alia arginine or arginine citrate.
  • Such compositions can contain relatively small proportions of propylene glycol as diluent along with relatively larger
  • GB-A-1,140,443 describes an antiseptic composition consisting of a saturated solution of salicylic acid in propylene glycol and in addition an antiseptic selected from sodium
  • compositions of GB-A-1,140,443 generally contained more than 10 wt % of salicylic acid and the patent is not concerned at all with treatment of dandruff or seborrhoeic dermatitis.
  • a possible reason for the actions of the combination therapy of the invention is that combinations of propylene glycol and
  • salicylic acid have enhanced activity against Pityrosporum ovale, an organism that is now thought to be implicated as an aetiological agent responsible for both psoriasis and seborrhoeic dermatitis and possibly also dandruff. Further the combinations of propylene glycol and salicylic acid exhibit an enhanced keratolytic action.
  • composition for use in the treatment of scaling conditions of the scalp including dandruff, seborrhoeic dermatitis and psoriasis which comprises as active ingredients, propylene glycol and salycylic acid. together with a topically acceptable excipient, the propylene glycol being present in a concentration of not greater than 50 wt % and the salicylic acid being present in a concentration of not greater than 10 wt %.
  • the concentration of propylene glycol is from to 50 wt %, most preferably from 10 to 40 wt %.
  • the salicylic acid is preferably present in a concentration of from 1 to 6 wt U, most preferably from 1 to 3 wt %.
  • compositions according to the invention may be formulated in the form of solutions, lotions or gels suitable for topical application, or in the form of a shampoo.
  • Compositions according to the invention may contain any conventional incidental adjuvents, for example, emolients, thickening agents, foaming agents, perfumes, colouring agents, stabilising agents, pH-adjusting agent and preservatives as well as water and/or ethanol.
  • Shampoos in accordance with the invention typically contain conventional detergent and/or surfactants to provide any necessary foaming and cleansing action.
  • the shampoos will contain perfuming ingredients and colouring agents and if desired other agents to make the product cosmetically acceptable, e.g. pearling agents, thickeners etc.
  • a method of treating dandruff and/or seborrhoeic dermatitis and/or psoriasis which comprises applying a composition according to the invention to the affected region.
  • compositions may be applied to the affected region at regular intervals of, for example. 1-5 and preferably 1-10 days.
  • the shampoo should be left on the hair, for example, for 1-5 minutes to enable the therapeutic effects of the proplylene glycol and salicylic acid to occur.
  • a lotion or gel also in accordance with the invention should be rubbed into the scalp and left in situ for 10 to 15 minutes. This combination of treatments has been found further to enhance the efficacy of the combination therapies of the invention.
  • the invention thus further provides a kit for use in the treatment of scaling conditions of the scalp, including dandruff, seborrhoeic dermatitis and psoriasis, comprising
  • a specific combination therapy according to the invention comprises

Abstract

A composition for use in the treatment of scaling conditions of the scalp, including dandruff, seborrhoeic dermatitis and psoriasis which comprises as active ingredients, propylene glycol and salicylic acid, together with a topically acceptable excipient, the propylene glycol being present in a concentration of not greater than 50 wt % and the salicylic acid being present in a concentration of not greater than 10 wt %.

Description

METHOD AND COMPOSITION FOR PREVENTION ANP/OR TREATMENT OF DANDRUFF AND
SEBORRHOEIC DERMATITIS
This invention relates to a method and composition for the prevention and/or treatment of scaling conditions of the scalp, such as dandruff, seborrhoeic dermatitis and psoriasis.
Previously known methods for preventing and treating dandruff generally involve applying to the scalp various anti-dandruff agents contained in lotions, gels and shampoos. Examples of such anti-dandruff agents include sulphur and selenium compounds, zinc pyrrithione and bacteriostatic and bacteriacidal agents such as, for example, hexachlorophene. In many individuals, the use of such anti-dandruff agents can give rise to adverse reactions, for example allergic reactions and erythematous lesions. Consequently, known anti-dandruff agents cannot be used in the long term and it is frequently found that dandruff symptoms recur. Known anti-dandruff agents are often difficult to formulate into cosmetically acceptable compositions .
Known treatments for seborrhoeic dermatitis and psoriasis generally involve the use of corticosteriods or other
pharmacologically active agents which have a profound metabolic effect.
UK Patent No. GB 2,205,743 described the finding that propylene glycol is effective as an anti-dandruff agent and that a significant anti-dandruff effect may be observed following application of propylene glycol to the scalp, e.g. in the form of a lotion, gel or shampoo. Propylene glycol, when used in accordance with the teachings of GB 2,205.743. avoided undesirable side effects which occur
following use of known anti-dandruff agents. Propylene glycol has hitherto also been described for use as a diluent, thinning agent or vehicle for various pharmaceutical products including such products intended for topical use. Thus
US-A-3,984,866 describes the use of certain alpha-substituted
carboxylic acid derivatives as active ingredients for treating keratinization defects.
Similarly DE-A-2,758,484 describes the use of chenodesoxic acid as the active ingredient of anti-dandruff compositions including lotions, gels and shampoos. This specification mentions propylene glycol as an ingredient of such compositions but not as an active ingredient.
DE-A-1,792,154 describes anti-dandruff cosmetic compositions containing as active ingredient, inter alia arginine or arginine citrate. Such compositions can contain relatively small proportions of propylene glycol as diluent along with relatively larger
proportions of ethanol.
GB-A-1,140,443 describes an antiseptic composition consisting of a saturated solution of salicylic acid in propylene glycol and in addition an antiseptic selected from sodium
dibromoxymercurifluorescein, sodium ethylmercurithio salycylate, iodine/sodium iodide mixtures and polyvinyl pyrrolidone-iodine complex. The compositions of GB-A-1,140,443 generally contained more than 10 wt % of salicylic acid and the patent is not concerned at all with treatment of dandruff or seborrhoeic dermatitis.
It has now been found that the anti-dandruff activity of propylene glycol can be synergistically enhanced by combining it with relatively low concentrations of salicylic acid (which itself, in such concentrations, would have a negligible anti-dandruff action).
Further such combinations have been found to be especially effective against more serious scaling conditions of the scalp, such as
seborrhoeic dermatitis and psoriasis.
A possible reason for the actions of the combination therapy of the invention is that combinations of propylene glycol and
salicylic acid have enhanced activity against Pityrosporum ovale, an organism that is now thought to be implicated as an aetiological agent responsible for both psoriasis and seborrhoeic dermatitis and possibly also dandruff. Further the combinations of propylene glycol and salicylic acid exhibit an enhanced keratolytic action.
According to one aspect of the invention there is provided composition for use in the treatment of scaling conditions of the scalp, including dandruff, seborrhoeic dermatitis and psoriasis which comprises as active ingredients, propylene glycol and salycylic acid. together with a topically acceptable excipient, the propylene glycol being present in a concentration of not greater than 50 wt % and the salicylic acid being present in a concentration of not greater than 10 wt %.
Preferably the concentration of propylene glycol is from to 50 wt %, most preferably from 10 to 40 wt %.
The salicylic acid is preferably present in a concentration of from 1 to 6 wt U, most preferably from 1 to 3 wt %.
The compositions according to the invention may be formulated in the form of solutions, lotions or gels suitable for topical application, or in the form of a shampoo. Compositions according to the invention may contain any conventional incidental adjuvents, for example, emolients, thickening agents, foaming agents, perfumes, colouring agents, stabilising agents, pH-adjusting agent and preservatives as well as water and/or ethanol.
Shampoos in accordance with the invention typically contain conventional detergent and/or surfactants to provide any necessary foaming and cleansing action. Normally the shampoos will contain perfuming ingredients and colouring agents and if desired other agents to make the product cosmetically acceptable, e.g. pearling agents, thickeners etc.
According to a further aspect of the invention there is provided a method of treating dandruff and/or seborrhoeic dermatitis and/or psoriasis which comprises applying a composition according to the invention to the affected region. In carrying out the method of the invention, the
compositions may be applied to the affected region at regular intervals of, for example. 1-5 and preferably 1-10 days. In the case of shampoos, the shampoo should be left on the hair, for example, for 1-5 minutes to enable the therapeutic effects of the proplylene glycol and salicylic acid to occur. Preferably, before shampooing, a lotion or gel also in accordance with the invention should be rubbed into the scalp and left in situ for 10 to 15 minutes. This combination of treatments has been found further to enhance the efficacy of the combination therapies of the invention.
The invention thus further provides a kit for use in the treatment of scaling conditions of the scalp, including dandruff, seborrhoeic dermatitis and psoriasis, comprising
(1) a supply of a gel or lotion as defined herein, and
(2) a supply of a shampoo as defined herein.
A specific combination therapy according to the invention comprises
(1) applying a gel or lotion according to the invention to the scalp and leaving it in situ for from 1 to 20, preferably 5 to 10 minutes, and
(2) washing the gel or lotion from the scalp using a
shampoo according to the invention.
The following examples illustrate compositions according to the invention:
1. Hair Treatment Lotion
wt %
A. Water - deionised 41.800
Polymer JR125 0.700
B. Propylene Glycol Mono 25.000
Phenonip 0.500
C. Ethanol B 100 20.000
Propylene Glycol Mono 10.000
Salicylic Acid 2.000 2. Shampoo
wt %
A. Water - deionised 20.000
Polymer JR30M 0.400
B. Water - deionised 1.400
Glucamate DOE 120 1.000
C. Empicol TL40T 30.000
Propylene Glycol Mono 25-000 Empigen BB 4.000 Tegobetain L7 6.000 Empilan CDE 5.000 Bronidox L 0.200
D. Propylene Glycol Mono 5-000
Salicylic Acid 2.000
3. Hair Treatment Lotion
100 g Lotion (or solution) contain:
Salicylic Acid 2,00 g Ethanol 21,20 g
Propylene Glycol 35,00 g Polyquaternium-10 0,70 g Water 41,10 g
Shampoo
wt %
Sodium Laureth Sulfate (25 wt %, with water) 38,0
Cocamidopropyl Betaine (30 wt %, with water) 15,0
Propylene Glycol 25, ,0
Salicylic Acid 2,0
PEG-120 Methylglucose Dioleate 2,0
Polyquaternium-10 0,5
Water ad 100

Claims

1. A composition for use in the treatment of scaling
conditions of the scalp, including dandruff, seborrhoeic dermatitis and psoriasis which comprisesO as active ingredients, propylene glycol and salycylic acid, together with a topically acceptable excipient, the propylene glycol being present in a concentration of not greater than 50 wt % and the salicylic acid being present in a concentration of not greater than 10 wt % .
2. A composition according to Claim 1 wherein the propylene glycol is present in a concentration of from 5 to 50 wt % .
3. A composition according to Claim 2 wherein the propylene glycol is present in a concentration of from 10 to 40 wt % .
4. A composition according to any preceding claim wherein the salicylic acid is present in a concentration of from 1 to 6 wt %.
5- A composition according to Claim 4 wherein the salicylic acid is present in a concentration of from 1 to 3 wt % .
6. A composition according to any preceding claim wherein the topically acceptable excipients comprise water and/or ethanol.
7. A composition according to any preceding claim in the form of a lotion or gel.
8. A composition according to any of Claims 1 to 6 in the form of a shampoo.
9- A method for the prevention and/or treatment of scaling conditions of the scalp, including dandruff, seborrhoeic dermatitis and psoriasis which comprises applying to the scalp a composition as claimed in any preceding claim.
10. A method according to Claim 9 which comprises applying to the scalp of a lotion or gel as claimed in Claim 7. followed by washing the hair with a shampoo as claimed in Claim 8,
PCT/EP1993/003060 1992-11-03 1993-11-02 Method and composition for prevention and/or treatment of dandruff and seborrhoeic dermatitis WO1994009755A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP93924089A EP0666734A1 (en) 1992-11-03 1993-11-02 Method and composition for prevention and/or treatment of dandruff and seborrhoeic dermatitis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9223034.1 1992-11-03
GB929223034A GB9223034D0 (en) 1992-11-03 1992-11-03 Method and composition for prevention and/or treatment of dandruff and seborrhoeic dermatitis

Publications (1)

Publication Number Publication Date
WO1994009755A1 true WO1994009755A1 (en) 1994-05-11

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ID=10724472

Family Applications (1)

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PCT/EP1993/003060 WO1994009755A1 (en) 1992-11-03 1993-11-02 Method and composition for prevention and/or treatment of dandruff and seborrhoeic dermatitis

Country Status (3)

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EP (1) EP0666734A1 (en)
GB (1) GB9223034D0 (en)
WO (1) WO1994009755A1 (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995013048A1 (en) * 1993-11-12 1995-05-18 The Procter & Gamble Company Desquamation compositions containing salicylic acid and zwitterionic compounds
WO1996001101A1 (en) * 1994-07-01 1996-01-18 The Procter & Gamble Company Desquamation compositions
WO1996011572A1 (en) * 1994-10-14 1996-04-25 Sven Moberg Antimicrobial composition
FR2740679A1 (en) * 1995-11-03 1997-05-09 Letourneur Raymond New shampoo composition comprising rainwater
US5681852A (en) * 1993-11-12 1997-10-28 The Procter & Gamble Company Desquamation compositions
WO1997048374A2 (en) * 1996-06-20 1997-12-24 The Procter & Gamble Company Perfume delivery systems in liquid personal cleansing compositions
WO1997048375A2 (en) * 1996-06-20 1997-12-24 The Procter & Gamble Company Perfume delivery systems in liquid personal cleansing compositions
US5821237A (en) * 1995-06-07 1998-10-13 The Procter & Gamble Company Compositions for visually improving skin
US5834409A (en) * 1995-03-31 1998-11-10 Colgate-Palmolive Company Scalp care products containing anti itching/anti irritant agents
DE10205193A1 (en) * 2002-02-08 2003-08-21 Beiersdorf Ag Cleaning preparations containing diol
EP1595530A1 (en) * 2004-05-10 2005-11-16 L'oreal Cosmetic or dermatological composition containing a surfactant, a monocarboxylic acid and a polyol
FR2943896A1 (en) * 2009-04-01 2010-10-08 Oreal "ROLL-ON" HAS HIGH SALICYLIC ACID CONTENT.

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53145925A (en) * 1977-05-23 1978-12-19 Kanebo Ltd Solid composition for softening corneous tissue
US4514385A (en) * 1981-10-05 1985-04-30 Alcon Laboratories, Inc. Anti-acne compositions
DD225913A1 (en) * 1984-06-22 1985-08-14 Miltitz Chem Werk ANTIBACTERIAL COMEDOLYTIC SUBSTANCE COMBINATION
FR2585575A1 (en) * 1985-08-01 1987-02-06 Pf Medicament Pharmaceutical compositions having keratolytic activity in the form of an aqueous alcoholic gel containing salicylic acid
WO1987004617A1 (en) * 1986-02-04 1987-08-13 Sven Moberg Pharmaceutical compositions containing propylene glycol and/or polyethylene glycol and urea as active main components and use thereof
WO1989000853A1 (en) * 1987-07-25 1989-02-09 Konrad Minninger Agent containing salicylic acid for treating lepidosis
EP0337289A1 (en) * 1988-04-10 1989-10-18 Konrad Minninger Pharmaceutical composition containing dithranol for the treatment of the skin exfoliative diseases

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53145925A (en) * 1977-05-23 1978-12-19 Kanebo Ltd Solid composition for softening corneous tissue
US4514385A (en) * 1981-10-05 1985-04-30 Alcon Laboratories, Inc. Anti-acne compositions
DD225913A1 (en) * 1984-06-22 1985-08-14 Miltitz Chem Werk ANTIBACTERIAL COMEDOLYTIC SUBSTANCE COMBINATION
FR2585575A1 (en) * 1985-08-01 1987-02-06 Pf Medicament Pharmaceutical compositions having keratolytic activity in the form of an aqueous alcoholic gel containing salicylic acid
WO1987004617A1 (en) * 1986-02-04 1987-08-13 Sven Moberg Pharmaceutical compositions containing propylene glycol and/or polyethylene glycol and urea as active main components and use thereof
WO1989000853A1 (en) * 1987-07-25 1989-02-09 Konrad Minninger Agent containing salicylic acid for treating lepidosis
EP0337289A1 (en) * 1988-04-10 1989-10-18 Konrad Minninger Pharmaceutical composition containing dithranol for the treatment of the skin exfoliative diseases

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 90, no. 18, 30 April 1979, Columbus, Ohio, US; abstract no. 142079, "antikeratilizing cosmetic compositions" *
DATABASE WPI Week 8549, Derwent World Patents Index; AN 85-303718 *
S.T.N., File Supplier, KARLSRUHE, DE, File Chemical Abstracts, vol103, nŸ 220624 & JP-A-59088421, pub. 22-5-84 see the abstract *
S.T.N., File Supplier, KARLSRUHE, DE, File Embase, an=83021705 'psoriasis', Anderson, 1982 see the abstract *

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995013048A1 (en) * 1993-11-12 1995-05-18 The Procter & Gamble Company Desquamation compositions containing salicylic acid and zwitterionic compounds
US5652228A (en) * 1993-11-12 1997-07-29 The Procter & Gamble Company Topical desquamation compositions
US5681852A (en) * 1993-11-12 1997-10-28 The Procter & Gamble Company Desquamation compositions
US5849728A (en) * 1993-11-12 1998-12-15 The Procter & Gamble Company Desquamation compositions
WO1996001101A1 (en) * 1994-07-01 1996-01-18 The Procter & Gamble Company Desquamation compositions
CN1107495C (en) * 1994-07-01 2003-05-07 纺织研究院公司 Desquamation compositions
WO1996011572A1 (en) * 1994-10-14 1996-04-25 Sven Moberg Antimicrobial composition
US5834409A (en) * 1995-03-31 1998-11-10 Colgate-Palmolive Company Scalp care products containing anti itching/anti irritant agents
US5821237A (en) * 1995-06-07 1998-10-13 The Procter & Gamble Company Compositions for visually improving skin
FR2740679A1 (en) * 1995-11-03 1997-05-09 Letourneur Raymond New shampoo composition comprising rainwater
WO1997048375A3 (en) * 1996-06-20 1998-02-05 Procter & Gamble Perfume delivery systems in liquid personal cleansing compositions
WO1997048374A3 (en) * 1996-06-20 1998-02-05 Procter & Gamble Perfume delivery systems in liquid personal cleansing compositions
US5804538A (en) * 1996-06-20 1998-09-08 The Procter & Gamble Company Perfume delivery systems in liquid personal cleansing compositions
WO1997048375A2 (en) * 1996-06-20 1997-12-24 The Procter & Gamble Company Perfume delivery systems in liquid personal cleansing compositions
WO1997048374A2 (en) * 1996-06-20 1997-12-24 The Procter & Gamble Company Perfume delivery systems in liquid personal cleansing compositions
DE10205193A1 (en) * 2002-02-08 2003-08-21 Beiersdorf Ag Cleaning preparations containing diol
EP1595530A1 (en) * 2004-05-10 2005-11-16 L'oreal Cosmetic or dermatological composition containing a surfactant, a monocarboxylic acid and a polyol
FR2943896A1 (en) * 2009-04-01 2010-10-08 Oreal "ROLL-ON" HAS HIGH SALICYLIC ACID CONTENT.

Also Published As

Publication number Publication date
GB9223034D0 (en) 1992-12-16
EP0666734A1 (en) 1995-08-16

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