WO1994010982A1 - Sustained-release microsphere containing antipsychotic and process for producing the same - Google Patents
Sustained-release microsphere containing antipsychotic and process for producing the same Download PDFInfo
- Publication number
- WO1994010982A1 WO1994010982A1 PCT/JP1993/001673 JP9301673W WO9410982A1 WO 1994010982 A1 WO1994010982 A1 WO 1994010982A1 JP 9301673 W JP9301673 W JP 9301673W WO 9410982 A1 WO9410982 A1 WO 9410982A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sustained
- acid
- antipsychotic
- release microsphere
- release
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4515—Non condensed piperidines, e.g. piperocaine having a butyrophenone group in position 1, e.g. haloperidol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP93924827A EP0669128B1 (en) | 1992-11-17 | 1993-11-15 | Sustained-release microsphere containing antipsychotic and process for producing the same |
DE69327542T DE69327542T2 (de) | 1992-11-17 | 1993-11-15 | Ein antipsychotikum enthaltende mikrokugel zur verzögerten freisetzung und verfahren für ihre herstellung |
DE0669128T DE669128T1 (de) | 1992-11-17 | 1993-11-15 | Ein antipsychotikum enthaltende mikrokugel zur verzögerten freisetzung und verfahren für ihre herstellung. |
AT93924827T ATE188375T1 (de) | 1992-11-17 | 1993-11-15 | Ein antipsychotikum enthaltende mikrokugel zur verzögerten freisetzung und verfahren für ihre herstellung |
KR1019950701853A KR100333115B1 (ko) | 1992-11-17 | 1993-11-15 | 항정신병약함유서방성마이크로스피어및이의제조방법 |
DK93924827T DK0669128T3 (da) | 1992-11-17 | 1993-11-15 | Sustained-release mikrosfære indeholdende antipsykotikum og fremgangsmåde til at fremstille samme |
GR960300020T GR960300020T1 (en) | 1992-11-17 | 1996-03-31 | Sustained-release microsphere containing antipsychotic and process for producing the same. |
US08/812,544 US5871778A (en) | 1992-11-17 | 1997-03-07 | Sustained release microsphere preparation containing antipsychotic drug |
GR20000400702T GR3033016T3 (en) | 1992-11-17 | 2000-03-21 | Sustained-release microsphere containing antipsychotic and process for producing the same. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4/332441 | 1992-11-17 | ||
JP33244192 | 1992-11-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1994010982A1 true WO1994010982A1 (en) | 1994-05-26 |
Family
ID=18255017
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP1993/001673 WO1994010982A1 (en) | 1992-11-17 | 1993-11-15 | Sustained-release microsphere containing antipsychotic and process for producing the same |
Country Status (11)
Country | Link |
---|---|
US (2) | US5656299A (ja) |
EP (1) | EP0669128B1 (ja) |
KR (1) | KR100333115B1 (ja) |
AT (1) | ATE188375T1 (ja) |
CA (1) | CA2148823C (ja) |
DE (2) | DE69327542T2 (ja) |
DK (1) | DK0669128T3 (ja) |
ES (1) | ES2077547T3 (ja) |
GR (2) | GR960300020T1 (ja) |
PT (1) | PT669128E (ja) |
WO (1) | WO1994010982A1 (ja) |
Cited By (41)
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WO1995013814A1 (en) * | 1993-11-19 | 1995-05-26 | Janssen Pharmaceutica N.V. | Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles |
EP0733368A1 (en) * | 1995-03-24 | 1996-09-25 | Eli Lilly And Company | Granule fomulation for olanzapine |
US5650173A (en) * | 1993-11-19 | 1997-07-22 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of biodegradable microparticles containing a biologically active agent |
US5654008A (en) * | 1993-11-19 | 1997-08-05 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of biodegradable microparticles containing a biologically active agent |
US5792477A (en) * | 1996-05-07 | 1998-08-11 | Alkermes Controlled Therapeutics, Inc. Ii | Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent |
US6331317B1 (en) | 1999-11-12 | 2001-12-18 | Alkermes Controlled Therapeutics Ii Inc. | Apparatus and method for preparing microparticles |
US6379703B1 (en) | 1998-12-30 | 2002-04-30 | Alkermes Controlled Therapeutics Inc., Ii | Preparation of microparticles having a selected release profile |
US6379704B2 (en) | 2000-05-19 | 2002-04-30 | Alkermes Controlled Therapeutics Inc. Ii | Method for preparing microparticles having a selected polymer molecular weight |
JP2002525330A (ja) * | 1998-09-30 | 2002-08-13 | イーライ・リリー・アンド・カンパニー | 2−メチル−チエノ−ベンゾジアゼピン製剤 |
US6495166B1 (en) | 1999-11-12 | 2002-12-17 | Alkermes Controlled Therapeutics Inc. | Apparatus and method for preparing microparticles using in-line solvent extraction |
US6495164B1 (en) | 2000-05-25 | 2002-12-17 | Alkermes Controlled Therapeutics, Inc. I | Preparation of injectable suspensions having improved injectability |
US6705757B2 (en) | 1999-11-12 | 2004-03-16 | Alkermes Controlled Therapeutics, Inc. Ii | Method and apparatus for preparing microparticles using in-line solvent extraction |
US6824822B2 (en) | 2001-08-31 | 2004-11-30 | Alkermes Controlled Therapeutics Inc. Ii | Residual solvent extraction method and microparticles produced thereby |
US6830737B2 (en) | 2000-09-27 | 2004-12-14 | Alkermes Controlled Therapeutics Inc. Ii | Apparatus for preparing microparticles using liquid-liquid extraction |
JP2007501235A (ja) * | 2003-08-06 | 2007-01-25 | アルカーメス コントロールド セラピューティクス,ツー | アリピプラゾールおよびハロペリドールのパモ酸塩 |
JP2007517902A (ja) * | 2004-01-12 | 2007-07-05 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア | 長期間送達製剤及びその使用方法 |
US7247319B2 (en) | 2000-12-27 | 2007-07-24 | Alkermes, Inc. | Preparation of microparticles having improved flowability |
WO2009001697A2 (en) | 2007-06-25 | 2008-12-31 | Otsuka Pharmaceutical Co., Ltd. | Microspheres having core/shell structure |
JP2009501798A (ja) * | 2005-07-18 | 2009-01-22 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア | 薬剤含有インプラント及びその使用方法 |
US7527809B2 (en) | 2003-05-02 | 2009-05-05 | Canon Kabushiki Kaisha | Polyhydroxyalkanoate-containing magnetic structure, and manufacturing method and use thereof |
US7615233B2 (en) | 2001-07-10 | 2009-11-10 | Canon Kabushiki Kaisha | Particulate construct comprising polyhydroxyalkanoate and method for producing it |
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JPS568318A (en) * | 1979-06-28 | 1981-01-28 | Janssen Pharmaceutica Nv | Non oral long acting composition of haloperidol and bromperidol derivative |
JPS59130211A (ja) * | 1982-10-07 | 1984-07-26 | ソシエテ・デチュ−ドウ・シャンテイフイック・エ・アンデュストリエル・ドウ・リ−ルドウフランス | スルピリドの新規な形態 |
JPS63122620A (ja) * | 1986-11-12 | 1988-05-26 | Sanraku Inc | ポリ乳酸マイクロスフエア及びその製造方法 |
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US4389330A (en) * | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
IE58110B1 (en) * | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
IT1216570B (it) * | 1988-04-08 | 1990-03-08 | Vectorpharma Int | Composizione farmaceutiche a rilascio controllato e procedimento per la loro preparazione. |
-
1993
- 1993-11-15 KR KR1019950701853A patent/KR100333115B1/ko not_active IP Right Cessation
- 1993-11-15 AT AT93924827T patent/ATE188375T1/de not_active IP Right Cessation
- 1993-11-15 EP EP93924827A patent/EP0669128B1/en not_active Revoked
- 1993-11-15 DE DE69327542T patent/DE69327542T2/de not_active Revoked
- 1993-11-15 PT PT93924827T patent/PT669128E/pt unknown
- 1993-11-15 ES ES93924827T patent/ES2077547T3/es not_active Expired - Lifetime
- 1993-11-15 WO PCT/JP1993/001673 patent/WO1994010982A1/ja not_active Application Discontinuation
- 1993-11-15 CA CA002148823A patent/CA2148823C/en not_active Expired - Fee Related
- 1993-11-15 DE DE0669128T patent/DE669128T1/de active Pending
- 1993-11-15 DK DK93924827T patent/DK0669128T3/da active
-
1995
- 1995-05-17 US US08/443,021 patent/US5656299A/en not_active Expired - Fee Related
-
1996
- 1996-03-31 GR GR960300020T patent/GR960300020T1/el unknown
-
1997
- 1997-03-07 US US08/812,544 patent/US5871778A/en not_active Expired - Fee Related
-
2000
- 2000-03-21 GR GR20000400702T patent/GR3033016T3/el not_active IP Right Cessation
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JPS568318A (en) * | 1979-06-28 | 1981-01-28 | Janssen Pharmaceutica Nv | Non oral long acting composition of haloperidol and bromperidol derivative |
JPS59130211A (ja) * | 1982-10-07 | 1984-07-26 | ソシエテ・デチュ−ドウ・シャンテイフイック・エ・アンデュストリエル・ドウ・リ−ルドウフランス | スルピリドの新規な形態 |
JPS63122620A (ja) * | 1986-11-12 | 1988-05-26 | Sanraku Inc | ポリ乳酸マイクロスフエア及びその製造方法 |
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Also Published As
Publication number | Publication date |
---|---|
CA2148823A1 (en) | 1994-05-26 |
EP0669128A1 (en) | 1995-08-30 |
US5656299A (en) | 1997-08-12 |
GR960300020T1 (en) | 1996-03-31 |
ES2077547T1 (es) | 1995-12-01 |
EP0669128B1 (en) | 2000-01-05 |
ATE188375T1 (de) | 2000-01-15 |
DE669128T1 (de) | 1996-03-14 |
ES2077547T3 (es) | 2000-06-16 |
PT669128E (pt) | 2000-06-30 |
DK0669128T3 (da) | 2000-06-19 |
DE69327542D1 (de) | 2000-02-10 |
KR100333115B1 (ko) | 2002-12-02 |
CA2148823C (en) | 1999-03-09 |
US5871778A (en) | 1999-02-16 |
GR3033016T3 (en) | 2000-08-31 |
EP0669128A4 (en) | 1996-09-25 |
DE69327542T2 (de) | 2000-07-06 |
KR950703936A (ko) | 1995-11-17 |
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